PAX7

Summary

Gene Symbol: PAX7
Description: paired box 7
Alias: HUP1, PAX7B, RMS2, paired box protein Pax-7, PAX7 transcriptional factor, paired box homeotic gene 7, paired domain gene 7
Species: human

Top Publications

  1. ncbi In vivo amplification of the PAX3-FKHR and PAX7-FKHR fusion genes in alveolar rhabdomyosarcoma
    F G Barr
    Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Hum Mol Genet 5:15-21. 1996
  2. ncbi Sclerosing rhabdomyosarcoma in adults: report of four cases of a hyalinizing, matrix-rich variant of rhabdomyosarcoma that may be confused with osteosarcoma, chondrosarcoma, or angiosarcoma
    Andrew L Folpe
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Am J Surg Pathol 26:1175-83. 2002
  3. ncbi Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization and fluorescence in situ hybridization: an intergroup rhabdomyosarcoma study
    J A Bridge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Genes Chromosomes Cancer 27:337-44. 2000
  4. ncbi Correlation between histology and PAX/FKHR fusion status in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group
    David M Parham
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Am J Surg Pathol 31:895-901. 2007
  5. doi Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma
    A Zibat
    Institute of Human Genetics, University of Goettingen, Goettingen, Germany
    Oncogene 29:6323-30. 2010
  6. doi The utility of FOXO1 fluorescence in situ hybridization (FISH) in formalin-fixed paraffin-embedded specimens in the diagnosis of alveolar rhabdomyosarcoma
    Erinn Downs-Kelly
    Department of Anatomic, Cleveland Clinic, Cleveland, OH 44195, USA
    Diagn Mol Pathol 18:138-43. 2009
  7. ncbi Heat stress facilitates the regeneration of injured skeletal muscle in rats
    Atsushi Kojima
    Department of Orthopaedic Surgery, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae, Kawasaki, 216 8511, Japan
    J Orthop Sci 12:74-82. 2007
  8. ncbi Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions
    Frederic G Barr
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 62:4704-10. 2002
  9. ncbi Malignant ectomesenchymoma: genetic profile reflects rhabdomyosarcomatous differentiation
    Giuseppe Floris
    Laboratory for Morphology and Molecular Pathology, University of Leuven, Belgium
    Diagn Mol Pathol 16:243-8. 2007
  10. pmc Alveolar rhabdomyosarcoma of the head and neck region in older adults: genetic characterization and a review of the literature
    Taketoshi Yasuda
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Hum Pathol 40:341-8. 2009

Research Grants

  1. Christopher D Kontos; Fiscal Year: 2014
  2. Christoph Lepper; Fiscal Year: 2014
  3. Defining the role of satellite cells in muscle maintenance throughout the lifespa
    Charlotte A Peterson; Fiscal Year: 2010
  4. Michael A Rudnicki; Fiscal Year: 2016
  5. Lisa J Bain; Fiscal Year: 2014
  6. Tools to study age-related changes in muscle stem cells
    Michael Kyba; Fiscal Year: 2010
  7. Pier Lorenzo Puri; Fiscal Year: 2016
  8. Thanh Huu Tran; Fiscal Year: 2014
  9. Christoph Lepper; Fiscal Year: 2015
  10. Examining the Therapeutic Potential of iPS cells in Duchenne Muscular Dystrophy
    Rita C R Perlingeiro; Fiscal Year: 2010

Detail Information

Publications287 found, 100 shown here

  1. ncbi In vivo amplification of the PAX3-FKHR and PAX7-FKHR fusion genes in alveolar rhabdomyosarcoma
    F G Barr
    Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Hum Mol Genet 5:15-21. 1996
    ..characteristic t(2;13)(q35;q14) or variant t(1;13)(p36;q14) chromosomal translocations generate PAX3-FKHR or PAX7-FKHR fusion genes...
  2. ncbi Sclerosing rhabdomyosarcoma in adults: report of four cases of a hyalinizing, matrix-rich variant of rhabdomyosarcoma that may be confused with osteosarcoma, chondrosarcoma, or angiosarcoma
    Andrew L Folpe
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Am J Surg Pathol 26:1175-83. 2002
    ..Reverse transcriptase polymerase chain reaction for the ARMS-associated PAX3/FKHR and PAX7/PKHF was also performed on three cases...
  3. ncbi Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization and fluorescence in situ hybridization: an intergroup rhabdomyosarcoma study
    J A Bridge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Genes Chromosomes Cancer 27:337-44. 2000
    ..Loss of 1p36 corresponds to the locus for PAX7, a paired box containing gene characteristically altered in alveolar rhabdomyosarcoma...
  4. ncbi Correlation between histology and PAX/FKHR fusion status in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group
    David M Parham
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Am J Surg Pathol 31:895-901. 2007
    ..ARMS) are characterized by 3 mutually exclusive PAX/FKHR conditions: PAX3/FKHR fusion (present in 60% of cases), PAX7/FKHR fusion (present in 20%), and PAX/FKHR fusion-negativity (present in 20%)...
  5. doi Activation of the hedgehog pathway confers a poor prognosis in embryonal and fusion gene-negative alveolar rhabdomyosarcoma
    A Zibat
    Institute of Human Genetics, University of Goettingen, Goettingen, Germany
    Oncogene 29:6323-30. 2010
    ..chromosomal translocations leading to fusion genes of the forkhead transcription factor FOXO1 and PAX3 or PAX7. The hedgehog (Hh) pathway has been implied in tumor formation and progression of various cancers including RMS...
  6. doi The utility of FOXO1 fluorescence in situ hybridization (FISH) in formalin-fixed paraffin-embedded specimens in the diagnosis of alveolar rhabdomyosarcoma
    Erinn Downs-Kelly
    Department of Anatomic, Cleveland Clinic, Cleveland, OH 44195, USA
    Diagn Mol Pathol 18:138-43. 2009
    ..neoplasm with unique t(2;13)(q35;q14) or t(1;13)(p36;q14) chromosomal translocations, resulting in PAX3/FOXO1 and PAX7/FOXO1 fusion genes, in approximately 80% of cases...
  7. ncbi Heat stress facilitates the regeneration of injured skeletal muscle in rats
    Atsushi Kojima
    Department of Orthopaedic Surgery, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae, Kawasaki, 216 8511, Japan
    J Orthop Sci 12:74-82. 2007
    ..The purpose of this study was to investigate the effect of heat stress on the regeneration of skeletal muscle injury induced by cardiotoxin...
  8. ncbi Genetic heterogeneity in the alveolar rhabdomyosarcoma subset without typical gene fusions
    Frederic G Barr
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 62:4704-10. 2002
    Previous studies of the PAX3-FKHR and PAX7-FKHR gene fusions in alveolar rhabdomyosarcoma (ARMS) indicated that the corresponding fusiontranscripts are not detectable in 20% of ARMS cases...
  9. ncbi Malignant ectomesenchymoma: genetic profile reflects rhabdomyosarcomatous differentiation
    Giuseppe Floris
    Laboratory for Morphology and Molecular Pathology, University of Leuven, Belgium
    Diagn Mol Pathol 16:243-8. 2007
    ..the marker chromosome was identified as originating from chromosome 6, and the tumor cells were negative for PAX3/PAX7 disrupting translocations specific for alveolar RMS...
  10. pmc Alveolar rhabdomyosarcoma of the head and neck region in older adults: genetic characterization and a review of the literature
    Taketoshi Yasuda
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Hum Pathol 40:341-8. 2009
    ..prognostic parameter in alveolar rhabdomyosarcoma is the identification of PAX3-FOXO1 [t(2;13)(q35;q14)] or PAX7-FOXO1 [t(1;13)(p36;q14)] rearrangements...
  11. pmc A Drosophila model of the rhabdomyosarcoma initiator PAX7-FKHR
    Rene L Galindo
    Division of Pediatric Pathology, Department of Pathology, Children s Medical Center, Dallas, TX 75235, USA
    Proc Natl Acad Sci U S A 103:13439-44. 2006
    ..is an aggressive myogenic-type tumor and a gain-of-function disease, caused by misexpression of the PAX3-FKHR or PAX7-FKHR fusion oncoprotein from structurally rearranged chromosomes...
  12. ncbi [Profile of chromosomal imbalances in 10 cases of primary alveolar rhabdomyosarcoma analyzed by comparative genomic hybridization]
    Qiao Xin Li
    Department of Pathology, Xinjiang Medical University, The First Affiliated Hospital, Urumqi 830054, China
    Zhonghua Zhong Liu Za Zhi 31:571-6. 2009
    ..The aim of this study was to characterize the profile of chromosomal imbalances of alveolar rhabdomyosarcoma (ARMS)...
  13. ncbi Fusions involving PAX and FOX genes in the molecular pathogenesis of alveolar rhabdomyosarcoma: recent advances
    Gabriela E Mercado
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Curr Mol Med 7:47-61. 2007
    ..These translocations form PAX3-FKHR and PAX7-FKHR gene fusions, which encode chimeric transcription factors...
  14. pmc Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma
    Sarasija Naini
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 68:9583-8. 2008
    ..and most characteristically, reciprocal translocation of loci involving the PAX and FKHR genes, generating the PAX7-FKHR or PAX3-FKHR fusion proteins...
  15. ncbi [Lineage-switching by pluripotent cells derived from adults]
    F Dieterlen-Lievre
    Institut d Embryologie Cellulaire et Moleculaire du CNRS et du College de France, 49 bis, avenue de la Belle Gabrielle, 94736 Nogent sur Marne
    J Soc Biol 195:39-46. 2001
    ..This consists in the expression of the Pax7 gene. Pax7-/- mouse muscles have no satellite cells, i.e...
  16. doi Alveolar rhabdomyosarcoma: is the cell of origin a mesenchymal stem cell?
    Elizabeth Charytonowicz
    School of Exercise Biomedical and Health Science, Edith Cowan University, 100 Joondalup Drive, Joondalup, WA 6027, Australia
    Cancer Lett 279:126-36. 2009
    ..Most ARMS tumors have t(2; 13) or t(1; 13) translocations, involving PAX3-FKHR and PAX7-FKHR fusion genes, respectively...
  17. pmc PAX3-FKHR induces morphological change and enhances cellular proliferation and invasion in rhabdomyosarcoma
    J Anderson
    Unit of Molecular Haematology, Institute of Child Health and Great Ormond Street Hospital for Children, London, United Kingdom
    Am J Pathol 159:1089-96. 2001
    ..with the characteristic translocations t(2;13)(q35;q14) and t(1;13)(p36;q14), which encode for the PAX3-FKHR and PAX7-FKHR fusion oncoproteins respectively...
  18. ncbi Cytogenetic and molecular studies of an unusual case of multiple primary alveolar rhabdomyosarcomas: low-level chromosomal instability and reciprocal translocation t(6;11)
    Zhiqin Wang
    Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0588, USA
    Exp Mol Pathol 82:58-62. 2007
    ..ARMS) have consistent chromosomal translocation of either t(2;13) or t(1;13), resulting in either PAX3-FKHR or PAX7-FKHR gene fusions. However, 20% of the cases diagnosed histologically are negative for these fusion genes...
  19. pmc Activated satellite cells in medial rectus muscles of patients with strabismus
    Rosalia S Antunes-Foschini
    Department of Ophthalmology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    Invest Ophthalmol Vis Sci 49:215-20. 2008
    ....
  20. doi Oestrogen receptors mediate oestrogen-induced increases in post-exercise rat skeletal muscle satellite cells
    D L Enns
    Department of Kinesiology and Physical Education, Wilfrid Laurier University, Waterloo, ON, Canada
    Acta Physiol (Oxf) 194:81-93. 2008
    ..We investigated whether muscle oestrogen receptors (ORs) mediate this effect through administration of an OR antagonist, ICI 182,780...
  21. pmc Muscular dystrophy begins early in embryonic development deriving from stem cell loss and disrupted skeletal muscle formation
    Deborah Merrick
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Dis Model Mech 2:374-88. 2009
    ..5, respectively) exhibit hyperproliferation and apoptosis of Myf5-positive embryonic myoblasts; attrition of Pax7-positive myoblasts in situ; and depletion of total Pax7 protein in late gestation...
  22. doi Expression of mRNA for specific fibroblast growth factors associates with that of the myogenic markers MyoD and proliferating cell nuclear antigen in regenerating and overloaded rat plantaris muscle
    Y Tanaka
    Laboratory of Human Performance and Fitness, Graduate School of Education, Hokkaido University, Sapporo, Hokkaido, Japan
    Acta Physiol (Oxf) 194:149-59. 2008
    ....
  23. pmc Integrated functions of Pax3 and Pax7 in the regulation of proliferation, cell size and myogenic differentiation
    Charlotte A Collins
    Dubowitz Neuromuscular Centre, UCL Institute of Child Health, London, United Kingdom
    PLoS ONE 4:e4475. 2009
    Pax3 and Pax7 are paired-box transcription factors with roles in developmental and adult regenerative myogenesis...
  24. ncbi Functional analysis of homeodomain-containing transcription factor Lbx1 in satellite cells of mouse skeletal muscle
    Shuichi Watanabe
    Molecular Embryology, Department of Biosciences, School of Science, Kitasato University, Kanagawa, 228 8555, Japan
    J Cell Sci 120:4178-87. 2007
    ..and incomplete myotube formation, concomitantly with the activation of the paired-box transcription factor Pax7 and depression of the myogenic regulatory factor MyoD...
  25. ncbi Pax7 and myogenic progression in skeletal muscle satellite cells
    Peter S Zammit
    Muscle Cell Biology Group, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK
    J Cell Sci 119:1824-32. 2006
    ..Quiescent satellite cells express the transcription factor Pax7 and when activated, coexpress Pax7 with MyoD. Most then proliferate, downregulate Pax7 and differentiate...
  26. ncbi Predominant expression of alternative PAX3 and PAX7 forms in myogenic and neural tumor cell lines
    F G Barr
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104 6082, USA
    Cancer Res 59:5443-8. 1999
    PAX3 and PAX7 are closely related paired box family members expressed during early neural and myogenic development...
  27. ncbi Satellite cells and utrophin are not directly correlated with the degree of skeletal muscle damage in mdx mice
    Akira Yamane
    Department of Pharmacology, Tsurumi University School of Dental Medicine, 2 1 3 Tsurumi, Tsurumi ku, Yokohama 230 8501, Japan
    Am J Physiol Cell Physiol 289:C42-8. 2005
    ..Furthermore, we analyzed the expression levels of the paired box homeotic gene 7 (pax7), m-cadherin (the makers of muscle satellite cells), and utrophin mRNA...
  28. doi Plasticity and recovery of skeletal muscle satellite cells during limb regeneration
    Jamie I Morrison
    A s, Karolinska Institute, Department of Cell and Molecular Biology, von Eulersväg 3, 17177 Stockholm, Sweden
    FASEB J 24:750-6. 2010
    ..We previously identified a Pax7(+) cell population in skeletal muscle whose progeny have the potential to contribute to the regenerating limb...
  29. pmc Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts
    Karen Fernandez
    Division of Hematology Oncology, Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Am J Pathol 176:416-34. 2010
    ..No Pax3:Fkhr or Pax7:Fkhr translocation mRNA products were evident in any tumor...
  30. doi SVEP1 is a novel marker of activated pre-determined skeletal muscle satellite cells
    Gabi Shefer
    Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel
    Stem Cell Rev 6:42-9. 2010
    ..b>Pax7 was used to pinpoint satellite cells situated in their niche on myofibers, and activated satellite cells were ..
  31. ncbi Pax7 is required for the specification of myogenic satellite cells
    P Seale
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Cell 102:777-86. 2000
    The paired box transcription factor Pax7 was isolated by representational difference analysis as a gene specifically expressed in cultured satellite cell-derived myoblasts...
  32. ncbi Oestrogen influence on myogenic satellite cells following downhill running in male rats: a preliminary study
    P M Tiidus
    Department of Kinesiology and Physical Education, Wilfrid Laurier University, Waterloo, ON, Canada
    Acta Physiol Scand 184:67-72. 2005
    ..This study examined the effect of oestrogen supplementation in rats on myogenic satellite cell quantities in type I and II muscles following eccentric exercise...
  33. pmc PAX genes and human neural tube defects: an amino acid substitution in PAX1 in a patient with spina bifida
    F A Hol
    Department of Human Genetics, University Hospital Nijmegen, The Netherlands
    J Med Genet 33:655-60. 1996
    ..To investigate the role of PAX1, PAX3, PAX7, and PAX9, allelic association studies were performed in 79 sporadic and 38 familial NTD patients from the Dutch ..
  34. pmc Temporally regulated neural crest transcription factors distinguish neuroectodermal tumors of varying malignancy and differentiation
    Timothy R Gershon
    Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Neoplasia 7:575-84. 2005
    ..We examined the expression of transcription factors PAX3, PAX7, AP-2alpha, and SOX10 in human embryos and neuroectodermal tumors: neurofibroma, schwannoma, neuroblastoma, ..
  35. ncbi BDNF is expressed in skeletal muscle satellite cells and inhibits myogenic differentiation
    Kambiz Mousavi
    Department of Cellular and Molecular Medicine, Center for Neuromuscular Disease, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada
    J Neurosci 26:5739-49. 2006
    ..Additionally, BDNF was expressed in Pax7+ satellite cells where it colocalized with p75NTR...
  36. ncbi Temperature influences the coordinated expression of myogenic regulatory factors during embryonic myogenesis in Atlantic salmon (Salmo salar L.)
    Daniel J Macqueen
    Gatty Marine Laboratory, School of Biology, University of St Andrews, St Andrews, Fife, KY16 8LB, UK
    J Exp Biol 210:2781-94. 2007
    ..data in the context of known muscle fibre differentiation events, the expression of slow myosin light chain-1 and Pax7 were also investigated...
  37. pmc Paclitaxel prodrugs with sustained release and high solubility in poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelle nanocarriers: pharmacokinetic disposition, tolerability, and cytotoxicity
    M Laird Forrest
    College of Pharmacy, Department of Pharmaceutical Chemistry, The University of Kansas, Simons Labs, Lawrence, KS 66047 3729, USA
    Pharm Res 25:194-206. 2008
    ....
  38. pmc Subcellular localization of the inducible Chlorella HUP1 monosaccharide-H+ symporter and cloning of a Co-induced galactose-H+ symporter
    R Stadler
    Lehrstuhl für Zellbiologie und Pflanzenphysiologie, Universitat Regensburg, Germany
    Plant Physiol 107:33-41. 1995
    ..The gene coding for the inducible HUP1 monosaccharide-H+ symporter has been cloned and the protein has been characterized previously...
  39. ncbi Structural characterization of the FKHR gene and its rearrangement in alveolar rhabdomyosarcoma
    R J Davis
    Department of Pathology and Labortory Medicine, University of Pennsylvania of Medicine, Phildelphia 19104 6082, USA
    Hum Mol Genet 4:2355-62. 1995
    The FKHR gene, which contains a forkhead DNA-binding motif, is fused to either PAX3 or PAX7 by the t(2;13) or t(1;13) translocation in alveolar rhabdomyosarcoma,respectively...
  40. ncbi Pax genes in development and maturation of the vertebrate visual system: implications for optic nerve regeneration
    M R Ziman
    Department of Zoology, University of Western Australia, Nedlands, Australia
    Histol Histopathol 16:239-49. 2001
    ..During development Pax7 is expressed in neuronal cells of one of the major visual targets in the brain, the optic tectum/superior ..
  41. ncbi Proliferative and apoptotic differences between alveolar rhabdomyosarcoma subtypes: a comparative study of tumors containing PAX3-FKHR or PAX7-FKHR gene fusions
    M H Collins
    Department of Pathology, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Med Pediatr Oncol 37:83-9. 2001
    ..common translocation fuses the PAX3 and FKHR genes; patients who have PAX3-FKHR-positive ARMS have reduced event-free survival compared to patients with ARMS containing the less common translocation that fuses the PAX7 and FKHR genes.
  42. ncbi Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma
    F G Barr
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 36th Street and Hamilton Walk, Philadelphia, Pennsylvania, PA 19104 6082, USA
    Oncogene 20:5736-46. 2001
    ..These translocations rearrange PAX3 and PAX7, members of the paired box transcription factor family, and juxtapose these genes with FKHR, a member of the fork ..
  43. ncbi Gene expression signatures identify rhabdomyosarcoma subtypes and detect a novel t(2;2)(q35;p23) translocation fusing PAX3 to NCOA1
    Marco Wachtel
    University Children s Hospital, Division of Oncology, Zurich, Switzerland
    Cancer Res 64:5539-45. 2004
    ..signature was used to classify an additional alveolar rhabdomyosarcoma case lacking any known PAX3 or PAX7 fusion as belonging to the translocation-positive group, leading to the identification of a novel translocation t(2;..
  44. ncbi Hedgehog signaling controls dorsoventral patterning, blastema cell proliferation and cartilage induction during axolotl tail regeneration
    Esther Schnapp
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 132:3243-53. 2005
    ..molecular markers of DV progenitor cell domains found during embryonic neural tube development, including Pax6, Pax7 and Msx1...
  45. pmc Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells
    Frederic Relaix
    Unité de Génétique Moléculaire du Développement, Centre National de la Recherche Scientifique URA 2578, Departement de Biologie du Developpement
    J Cell Biol 172:91-102. 2006
    ..and repair of skeletal muscle after birth depends on satellite cells that are characterized by the expression of Pax7. We show that Pax3, the paralogue of Pax7, is also present in both quiescent and activated satellite cells in many ..
  46. ncbi MyoD and Myogenin expression during myogenic phases in brown trout: a precocious onset of mosaic hyperplasia is a prerequisite for fast somatic growth
    P Steinbacher
    Division of Zoology and Functional Anatomy, Department of Organismic Biology, University of Salzburg, Salzburg, Austria
    Dev Dyn 236:1106-14. 2007
    ..Furthermore, we suggest that Pax7 is expressed in myogenic progenitor cells that account for second- and third-phase myogenesis...
  47. ncbi Antagonism of myostatin enhances muscle regeneration during sarcopenia
    Victoria Siriett
    Functional Muscle Genomics, AgResearch, Hamilton, New Zealand
    Mol Ther 15:1463-70. 2007
    ..Antagonism of myostatin led to satellite cell activation, increased Pax7 and MyoD protein levels, and greater myoblast and macrophage cell migration, resulting in enhanced muscle ..
  48. ncbi Growth in the larval zebrafish pectoral fin and trunk musculature
    Sara E Patterson
    Department of Biology, Wesleyan University, Middletown, Connecticut 06459, USA
    Dev Dyn 237:307-15. 2008
    ..to the skin, and this correlates with the expression of myogenic genes such as muscle regulatory factors and Pax7. Our results suggest that regulation of fiber type development and muscle growth may differ in the pectoral fin and ..
  49. doi Detection of FOXO1 (FKHR) gene break-apart by fluorescence in situ hybridization in formalin-fixed, paraffin-embedded alveolar rhabdomyosarcomas and its clinicopathologic correlation
    Shveta Mehra
    Department of Pathology, SUNY Upstate Medical University, Syracuse, NY, USA
    Diagn Mol Pathol 17:14-20. 2008
    Chromosomal translocations of t(2;13)(q35;q14) and t(1;13)(p36;q14), resulting in PAX3-FOXO1 (FKHR) and PAX7-FOXO1 (FKHR) gene fusions, have been found to be specific molecular markers for alveolar rhabdomyosarcomas (ARMS) and can be ..
  50. doi Properties of branchiomeric and somite-derived muscle development in Tbx1 mutant embryos
    Raphälle Grifone
    Inserm Avenir Group, Developmental Biology Institute of Marseilles Luminy, UMR CNRS 6216 Université de la Méditerranée, Campus de Luminy, Marseille, France
    Dev Dyn 237:3071-8. 2008
    ..Sporadic hypoplastic mandibular muscles in Tbx1-/- embryos contain Pax7-positive myocytes with indistinguishable differentiation properties from wild-type muscles and have normal tendon ..
  51. pmc The role of Delta-like 1 shedding in muscle cell self-renewal and differentiation
    Danqiong Sun
    Department of Biochemistry, Kansas State University, Manhattan, KS 66506, USA
    J Cell Sci 121:3815-23. 2008
    ..in vitro or C2C12 myogenic cells, we found that Notch activity is essential for maintaining the expression of Pax7, a transcription factor associated with the self-renewal lineage, in quiescent undifferentiated myoblasts after ..
  52. pmc Thermal manipulations in late-term chick embryos have immediate and longer term effects on myoblast proliferation and skeletal muscle hypertrophy
    Yogev Piestun
    Department of Animal Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    J Appl Physiol (1985) 106:233-40. 2009
    ..DNA incorporation of thymidine and a higher number of cells expressing PCNA in intact muscle, accompanied by higher Pax7 levels, all reflecting a higher number of myogenic cells, and suggesting that the increased hypertrophy can be ..
  53. pmc Laminin-111 restores regenerative capacity in a mouse model for alpha7 integrin congenital myopathy
    Jachinta E Rooney
    Department of Pharmacology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    Am J Pathol 174:256-64. 2009
    ..Analysis of Pax7 and MyoD expression revealed a profound delay in satellite cell activation after cardiotoxin treatment in alpha7 ..
  54. pmc Local NSAID infusion inhibits satellite cell proliferation in human skeletal muscle after eccentric exercise
    U R Mikkelsen
    Institute of Sports Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, Copenhagen DK 2400, Denmark
    J Appl Physiol (1985) 107:1600-11. 2009
    ..Satellite cells were identified using antibodies against neural cell adhesion molecule and Pax7. The number of Pax7(+) cells per myofiber was increased by 96% on day 8 after exercise in the unblocked leg (0...
  55. doi Numb promotes an increase in skeletal muscle progenitor cells in the embryonic somite
    Aurélie Jory
    Stem Cells and Development, Department of Developmental Biology Pasteur Institute, Centre National de la Recherche Scientifique CNRS URA 2578, 75724 Paris Cedex 15, France
    Stem Cells 27:2769-80. 2009
    Multiple cell types arise from cells in the dermomyotome of the somite that express Pax3 and Pax7, and myogenesis is regulated by Notch signaling...
  56. doi Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR
    Shigeru Sato
    Division of Biology, Center for Molecular Medicine, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke, Tochigi 329 0498, Japan
    Dev Biol 344:158-71. 2010
    ..protein-binding sites of Six1-14, the Six1 rostral PPR enhancer, for enhancer activity, and that Dlx5, Msx1 and Pax7 are candidate binding factors that regulate the level and area of Six1 expression, and thereby the location of the ..
  57. pmc Syndecan-3 and Notch cooperate in regulating adult myogenesis
    Addolorata Pisconti
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    J Cell Biol 190:427-41. 2010
    ..to reduced proliferation, increased cell death, delayed onset of differentiation, and markedly reduced numbers of Pax7(+) satellite cells accompanied by myofiber hypertrophy and an increased number of centrally nucleated myofibers...
  58. pmc Testicular fusocellular rhabdomyosarcoma as a metastasis of elbow sclerosing rhabdomyosarcoma: A clinicopathologic, immunohistochemical and molecular study of one case
    Miguel Martorell
    Department of Pathology, Hospital General Universitario de Valencia, University of Valencia, Spain
    Diagn Pathol 5:52. 2010
    ..PCR chimeric transcriptional products PAX3-FKHR and PAX7-FKHR were not found...
  59. ncbi [Induced pluripotent stem (iPS) cell-based cell therapy for muscular dystrophy: current progress and future prospects]
    Takashi Nishiyama
    Department of Molecular Therapy, National Institute of Neuroscience, Tokyo, Japan
    Brain Nerve 64:39-46. 2012
    ..most promising method for generating muscle stem cells from iPS cells is the conditional overexpression of Pax3 or Pax7 in the differentiating mouse embryoid bodies...
  60. pmc Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development
    Zsuzsa Agoston
    Institute of Neurology Edinger Institute, J, W, Goethe University Medical School, Heinrich Hoffmannstr, 7, 50628 Frankfurt, Germany
    BMC Dev Biol 12:10. 2012
    ..Much less, however, is known about the regulatory relationship and functional interaction of molecules that are expressed in the tectal anlage after tectal fate specification has taken place and tectal development has commenced...
  61. doi Perivascular mesenchymal progenitors in human fetal and adult liver
    Jörg C Gerlach
    Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Stem Cells Dev 21:3258-69. 2012
    ..CD31, CD34, CD45, CD144, CD326, CK19, albumin, α-fetoprotein, CYP3A7, glial fibrillary acid protein, MYF5, and Pax7 by gene expression; myogenin and alpha-smooth muscle actin expression were variable...
  62. doi Two distinct muscle progenitor populations coexist throughout amniote development
    Cyril A Picard
    EMBL Australia, Australian Regenerative Medicine Institute ARMI, Monash University, Building 75, Clayton, VIC 3800, Australia
    Dev Biol 373:141-8. 2013
    ..life in both chick and mouse: a minor, slow-cycling pool of undifferentiated resident progenitors which express Pax7, co-existing with a major fast-cycling population that co-express Pax7 and the early myogenic differentiation ..
  63. doi Isolation and biological characteristics of beijing Fatty chicken skeletal muscle satellite cells
    Chunyu Bai
    Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China
    Cell Commun Adhes 19:69-77. 2012
    ..1% collagenase 1 and 0.25% trypsin. Myogenic markers such as MyoD, Pax7 and demin were detected, indicating their skeletal muscle satellite cell identity...
  64. pmc Dynamic and differential regulation of stem cell factor FoxD3 in the neural crest is Encrypted in the genome
    Marcos S Simões-Costa
    Division of Biology, California Institute of Technology, Pasadena, California, USA
    PLoS Genet 8:e1003142. 2012
    ..analysis, in vivo chromatin immunoprecipitation, and morpholino knock-downs reveal that transcription factors Pax7 and Msx1/2 cooperate with the neural crest specifier gene, Ets1, to bind to the cranial NC1 regulatory element...
  65. pmc Skeletal muscle cells express ICAM-1 after muscle overload and ICAM-1 contributes to the ensuing hypertrophic response
    Christopher L Dearth
    Department of Kinesiology, The University of Toledo, Toledo, Ohio, United States of America
    PLoS ONE 8:e58486. 2013
    ..Furthermore, expression of ICAM-1 altered (p<0.05) the temporal pattern of Pax7 expression, a marker of satellite cells/myoblasts, and regenerating myofiber formation in overloaded muscles...
  66. doi SPARC is up-regulated during skeletal muscle regeneration and inhibits myoblast differentiation
    Stine Juhl Petersson
    Department of Clinical Pathology, and Department of Endocrinology, Section for Molecular Diabetes and Metabolism, Institute of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark
    Histol Histopathol 28:1451-60. 2013
    ..myogenic differentiation in these cultures as determined by substantially reduced levels of myogenic factors (Pax7, Myf5, Myod, Mef2B, Myogenin, and Myostatin) and a lack of multinucleated myotubes...
  67. pmc A novel approach to collecting satellite cells from adult skeletal muscles on the basis of their stress tolerance
    Taeko Shigemoto
    Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Stem Cells Transl Med 2:488-98. 2013
    ..Although the transcription factor Pax7 is a known specific marker of satellite cells, it is not located on the cell surface and therefore flow cytometry ..
  68. pmc Regeneration of injured skeletal muscle in heat shock transcription factor 1-null mice
    Sono Nishizawa
    Department of Orthopaedic Surgery, St Marianna University School of Medicine Kawasaki, Japan
    Physiol Rep 1:e00071. 2013
    ..Injury-related increase of Pax7-positive muscle satellite cells in HSF1-null mice was inhibited versus wild-type mice...
  69. pmc Early fish myoseptal cells: insights from the trout and relationships with amniote axial tenocytes
    Yoann Bricard
    French National Institute for Agricultural Research, Fish Physiology and Genomics, Rennes, France
    PLoS ONE 9:e91876. 2014
    ..The myoseptal cells do not express myogenic markers such as Pax3, Pax7 and myogenin but express several tendon-associated collagens including col1a1, col5a2 and col12a1 and angiopoietin-..
  70. doi Abnormalities in early markers of muscle involvement support a delay in myogenesis in spinal muscular atrophy
    Rebeca Martínez-Hernández
    From the Department of Molecular Biology, Hospital La Princesa, Madrid RM H and Department of Genetics, IIB Sant Pau Research Institute, Hospital de Sant Pau and Centro de Investigación Biomédica en Red de Enfermedades Raras SB, LA and Department of Clinical and Molecular Genetics, Hospital Valle Hebron, Passeig Valle Hebron EFT, Barcelona, Spain
    J Neuropathol Exp Neurol 73:559-67. 2014
    ..We also studied the expression of Pax7-positive nuclei as a marker of satellite cells and found no differences between control and SMA prenatal samples...
  71. pmc Notch signaling deficiency underlies age-dependent depletion of satellite cells in muscular dystrophy
    Chunhui Jiang
    Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA
    Dis Model Mech 7:997-1004. 2014
    ..cell composition is altered even in young mdx mice, with significant reductions in the abundance of non-committed (Pax7+ and Myf5-) satellite cells...
  72. doi Comparative gene expression analyses reveal heterochrony for Sox9 expression in the cranial neural crest during marsupial development
    Yoshio Wakamatsu
    Department of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine ART, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980 8575, Japan
    Evol Dev 16:197-206. 2014
    ..the expression of genes known to be important for neural crest formation, such as BMP2/BMP4 (neural crest inducer), Pax7 (neural border specifier), Snail1 and Sox9/Sox10 (neural crest specifier) in Monodelphis domestica, and compared ..
  73. pmc Lkb1 is indispensable for skeletal muscle development, regeneration, and satellite cell homeostasis
    Tizhong Shan
    Department of Animal Sciences, Purdue University, West Lafayette, Indiana, USA
    Stem Cells 32:2893-907. 2014
    ..Although tamoxifen-induced postnatal deletion of Lkb1 in satellite cells using Pax7(CreER) mice bypasses the developmental defects and early death, Lkb1 null satellite cells lose their regenerative ..
  74. pmc Extraocular muscle satellite cells are high performance myo-engines retaining efficient regenerative capacity in dystrophin deficiency
    Pascal Stuelsatz
    Department of Biological Structure, University of Washington School of Medicine, Seattle, WA, USA
    Dev Biol 397:31-44. 2015
    ..that EOMs, regardless of their distinctive Pax3-negative lineage origin, harbor SCs that share a common signature (Pax7(+), Ki67(-), Nestin-GFP(+), Myf5(nLacZ+), MyoD-positive lineage origin) with their limb and diaphragm somite-..
  75. doi Mixed lactate and caffeine compound increases satellite cell activity and anabolic signals for muscle hypertrophy
    Yoshimi Oishi
    Graduate School of Sport and Health Science, Ritsumeikan University, Shiga
    J Appl Physiol (1985) 118:742-9. 2015
    ..LC significantly increased protein levels of Pax7, MyoD, and Ki67 in addition to myogenin, relative to control...
  76. doi Insulin-like growth factor-1 (IGF-1) promotes myoblast proliferation and skeletal muscle growth of embryonic chickens via the PI3K/Akt signalling pathway
    Minli Yu
    Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, PR China
    Cell Biol Int 39:910-22. 2015
    ..IGF-1 administration obviously promoted the incorporation of BrdU and remarkably increased the number of PAX7-positive cells in the skeletal muscle of chicken embryos...
  77. doi Effects of eldecalcitol on bone and skeletal muscles in glucocorticoid-treated rats
    Hayato Kinoshita
    Department of Orthopedic Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    J Bone Miner Metab 34:171-8. 2016
    ..b>Pax7, MyoD, and myogenin mRNA levels in gastrocnemius muscles were also determined...
  78. pmc Post-exercise cold water immersion attenuates acute anabolic signalling and long-term adaptations in muscle to strength training
    Llion A Roberts
    University of Queensland, School of Human Movement Studies and Nutrition Sciences, Brisbane, Australia
    J Physiol 593:4285-301. 2015
    ..The number of satellite cells expressing neural cell adhesion molecule (NCAM) (10-30%) and paired box protein (Pax7) (20-50%) increased 24-48 h after exercise with ACT...
  79. pmc Network Analysis for the Identification of Differentially Expressed Hub Genes Using Myogenin Knock-down Muscle Satellite Cells
    Adeel Malik
    School of Biotechnology, Yeungnam University, Gyeongsan, Republic of Korea Perdana University Centre for Bioinformatics, MARDI Complex, Jalan MAEPS Perdana, 43400 Serdang, Selangor, Malaysia
    PLoS ONE 10:e0133597. 2015
    ..Subsequent to a decline in Pax7, induction in the expression of MYOG is a hallmark of myoblasts that have entered the differentiation phase ..
  80. pmc Satellite cell activity, without expansion, after nonhypertrophic stimuli
    Sophie Joanisse
    Departments of Kinesiology, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 309:R1101-11. 2015
    ..Specifically, the number of activated (Pax7(+)/MyoD(+), P ≤ 0.05) and differentiating (Pax7(-)/MyoD(+), P ≤ 0...
  81. pmc Characteristics of Skeletal Muscle Fibers of SOD1 Knockout Mice
    Hiroshi Nagahisa
    Biological Sciences, Graduate School of Medicine, Yamaguchi University, Yamaguchi, Yamaguchi Perfecture 753 8515, Japan
    Oxid Med Cell Longev 2016:9345970. 2016
    ..In addition, the mRNA expression levels of Pax7 and myogenin, which are expressed in satellite cells in the activation, proliferation, and differentiation states, ..
  82. doi Generation and validation of PAX7 reporter lines from human iPS cells using CRISPR/Cas9 technology
    Jianbo Wu
    Center for Stem Cell and Regenerative Medicine CSCRM, The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases IMM, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Stem Cell Res 16:220-8. 2016
    ..Here, we have generated a knock-in human iPS cell line for the early myogenic lineage specification gene of PAX7. By introduction of site-specific double-stranded breaks (DSB) in the genomic locus of PAX7 using CRISPR/Cas9 ..
  83. pmc A multi-ethnic genome-wide association study identifies novel loci for non-syndromic cleft lip with or without cleft palate on 2p24.2, 17q23 and 19q13
    Elizabeth J Leslie
    Department of Oral Biology, Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Hum Mol Genet 25:2862-2872. 2016
    ..17 × 10-8). Other regions reaching genome-wide significance were 1p36 (PAX7), 1p22 (ARHGAP29), 1q32 (IRF6), 8q24 and 17p13 (NTN1), all reported in previous GWASs...
  84. pmc Lkb1 deletion upregulates Pax7 expression through activating Notch signaling pathway in myoblasts
    Tizhong Shan
    Department of Animal Science, Zhejiang University, Hangzhou, Zhejiang 310058, China Department of Animal Science, Purdue University, West Lafayette, IN 47907, USA Electronic address
    Int J Biochem Cell Biol 76:31-8. 2016
    ..b>Pax7 is a defining marker of quiescent and activated satellite cells, but not differentiated myoblast...
  85. doi Myogenic potential of mouse embryonic stem cells lacking functional Pax7 tested in vitro by 5-azacitidine treatment and in vivo in regenerating skeletal muscle
    Anita Helinska
    Department of Cytology, Institute of Zoology, Faculty of Biology, University of Warsaw, Poland
    Eur J Cell Biol . 2016
    ..Among the factors crucial for the specification of myogenic precursor cells is Pax7 that sustains proper function of satellite cells...
  86. pmc Pax7 is critical for the normal function of satellite cells in adult skeletal muscle
    Julia von Maltzahn
    Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada K1H 8L6
    Proc Natl Acad Sci U S A 110:16474-9. 2013
    Extensive analyses of mice carrying null mutations in paired box 7 (Pax7) have confirmed the progressive loss of the satellite cell lineage in skeletal muscle, resulting in severe muscle atrophy and death...
  87. pmc Identification of Histone Deacetylase 2 as a Functional Gene for Skeletal Muscle Development in Chickens
    Md Shahjahan
    State Key Laboratory of Animal Nutrition, Beijing 100193, China
    Asian-Australas J Anim Sci 29:479-86. 2016
    ..myoblast proliferation in vitro declined between 24 h and 48 h when expression of the marker gene paired box 7 (PAX7) increased and cell numbers increased throughout 72 h of culture...
  88. ncbi PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development
    J D Burrill
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Development 124:4493-503. 1997
    ..the expression domains of PAX2, EN1 and EVX1 in postmitotic neurons correlate closely with those of Pax6 and Pax7 in the ventricular zone, implicating these patterning genes in the regulation of PAX2, EN1 and EVX1...
  89. ncbi Use of reverse transcriptase polymerase chain reaction for diagnosis and staging of alveolar rhabdomyosarcoma, Ewing sarcoma family of tumors, and desmoplastic small round cell tumor
    U H Athale
    Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    J Pediatr Hematol Oncol 23:99-104. 2001
    ..MATERIALS AND METHODS: RT-PCR assays for the EWS-FLII, EWS-ERG, PAX3-FKHR, PAX7-FKHR, and EWS-WTI fusion transcripts were performed on RNA extracted from the primary tumor tissue, bone marrow, ..
  90. pmc Pax7 directs postnatal renewal and propagation of myogenic satellite cells but not their specification
    Svetlana Oustanina
    Institute of Physiological Chemistry, University of Halle Wittenberg, Halle, Germany
    EMBO J 23:3430-9. 2004
    The paired-box transcription factor Pax7 has been claimed to specify the muscle stem cell lineage since inactivation of Pax7 led to a failure to detect muscle satellite cells...
  91. pmc FOXO1a acts as a selective tumor suppressor in alveolar rhabdomyosarcoma
    Philippe R J Bois
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Cell Biol 170:903-12. 2005
    ..Although both forms of RMS express muscle cell-specific markers, only ARMS cells express PAX3-FOXO1a or PAX7-FOXO1a chimeric proteins...
  92. pmc Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population
    Jamie I Morrison
    Department of Cell and Molecular Biology, Karolinska Institute, 17177 Stockholm, Sweden
    J Cell Biol 172:433-40. 2006
    ..We describe a multipotent Pax7+ satellite cell population located within the skeletal muscle of the salamander limb...
  93. ncbi Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomas
    Elai Davicioni
    Department of Pathology and Preventive Medicine, Keck School of Medicine, and Norris Comprehensive Cancer Center, University of Southern California 90027, USA
    Cancer Res 66:6936-46. 2006
    ..Most ARMS tumors express the PAX3-FKHR or PAX7-FKHR (PAX-FKHR) fusion genes resulting from the t(2;13) or t(1;13) chromosomal translocations, respectively...
  94. ncbi Pax7 and superior collicular polarity: insights from Pax6 (Sey) mutant mice
    Jennifer A Thompson
    School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup Drive, Joondalup, WA, 6027, Australia
    Exp Brain Res 178:316-25. 2007
    Pax genes are important modulators of CNS development. Pax7 and Pax6 polarise the neural tube and regionalise the brain...
  95. ncbi Stem and progenitor cells in skeletal muscle development, maintenance, and therapy
    Bruno Peault
    Stem Cell Research Center, Children s Hospital of Pittsburgh, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Mol Ther 15:867-77. 2007
    ..In addition to anatomic location, satellite cells are typified by markers such as M-cadherin, Pax7, Myf5, and neural cell adhesion molecule-1...
  96. ncbi Analysis of the callipyge phenotype through skeletal muscle development; association of Dlk1 with muscle precursor cells
    Jason D White
    School of Veterinary Science, The University of Melbourne, Parkville, VIC 3010, Australia
    Differentiation 76:283-98. 2008
    ..In addition, Dlk1 immuno-localization was associated with a sub-population of Pax7-positive mononucleated cells in all skeletal muscles examined during fetal development and at birth, but this was ..
  97. doi mls-2 and vab-3 Control glia development, hlh-17/Olig expression and glia-dependent neurite extension in C. elegans
    Satoshi Yoshimura
    The Rockefeller University, Laboratory of Developmental Genetics, 1230 York Avenue, New York, NY 10065, USA
    Development 135:2263-75. 2008
    ..We demonstrate ventral- and dorsal-restricted roles for the mls-2/Nkx/Hmx and vab-3/Pax6/Pax7 genes, respectively, in CEPsh glia differentiation and expression of the genes hlh-17/Olig and ptr-10/Patched-..
  98. pmc Pax7 is requisite for maintenance of a subpopulation of superior collicular neurons and shows a diverging expression pattern to Pax3 during superior collicular development
    Jennifer A Thompson
    School of Exercise, Biomedical and Health Science, Edith Cowan University, Joondalup Drive, Joondalup, Western Australia 6027, Australia
    BMC Dev Biol 8:62. 2008
    b>Pax7 encodes a transcription factor well-established as an important determinant of mesencephalic identity and superior collicular development...
  99. doi The embryonic midbrain directs neuronal specification of embryonic stem cells at early stages of differentiation
    José Manuel Baizabal
    Department of Developmental Genetics and Molecular Physiology, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Mor, Mexico
    Dev Biol 325:49-59. 2009
    ..1(+) red nucleus (RN) neurons, Nkx2.2(+) ventral interneurons and Pax7(+) dorsal neurons at the correct positions...
  100. doi A novel PAX3 rearrangement in embryonal rhabdomyosarcoma
    Hajime Hosoi
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Cancer Genet Cytogenet 189:98-104. 2009
    ..These translocations produce the PAX3-FOXO1 and PAX7-FOXO1 fusion genes, respectively...
  101. doi Neural crest ontogeny during secondary neurulation: a gene expression pattern study in the chick embryo
    Liliana Osório
    UPMC Univ Paris 06, UMR 7622, Laboratoire de Biologie du Developpement, Paris, France
    Int J Dev Biol 53:641-8. 2009
    ..of secondary NCC involves, as in primary neurulation, the activity of several transcription factors such as Pax3, Pax7, Snail2, FoxD3 and Sox9, which are all expressed in the dorsal secondary neural tube as soon as full cavitation is ..

Research Grants56

  1. Christopher D Kontos; Fiscal Year: 2014
    ..Bag3 induced an increase in Pax7+ progenitor cells, which stained positive for SMA and CD31, suggesting that Bag3 induced an increase in vascular ..
  2. Christoph Lepper; Fiscal Year: 2014
    ..Together with Pax7, their expression represents a sequence of events, from muscle progenitor to terminally differentiated state, ..
  3. Defining the role of satellite cells in muscle maintenance throughout the lifespa
    Charlotte A Peterson; Fiscal Year: 2010
    ..To overcome this obstacle, in Aim 1 we will generate the Pax7-GNZ mouse by crossing the conditional, satellite cell-specific driver/inducer mouse line (Pax7-CreER) with a ..
  4. Michael A Rudnicki; Fiscal Year: 2016
    ..The transcription factor Pax7 is expressed in satellite cells and is required for satellite cell survival and function through satellite cell ..
  5. Lisa J Bain; Fiscal Year: 2014
    ..the neural plate border specifier cells, which express transcription factors involved in myogenesis, such as Pax3, Pax7, Dlx5, Msx1, and Msx2, and are responsible for secreting factors that lead to the formation of the neural crest ..
  6. Tools to study age-related changes in muscle stem cells
    Michael Kyba; Fiscal Year: 2010
    ..The myogenic master regulator, Pax7, is expressed in a highly selective manner in muscle stem cells, and is absolutely and non-redundantly required for ..
  7. Pier Lorenzo Puri; Fiscal Year: 2016
    ..2b Analyze the p38-dependent repression of Pax7 in ESC BAF60c/MyoD. Aim 3...
  8. Thanh Huu Tran; Fiscal Year: 2014
    ..injury and by muscular dystrophy in mice having Sulfs specifically inactivated in the satellite cells Pax7Sulf-DN (Pax7-Cre:ER/Rosa26;eYFP/Sulf1/2flox) and Pax7Sulf-DN;mdx, respectively...
  9. Christoph Lepper; Fiscal Year: 2015
    ..I have obtained evidence that, in the mouse model, this process depends on the function of the Pax7 gene, which encodes a transcription factor...
  10. Examining the Therapeutic Potential of iPS cells in Duchenne Muscular Dystrophy
    Rita C R Perlingeiro; Fiscal Year: 2010
    ..combining the generation of iPS cells with our approach to derive myogenic progenitors by conditional expression of Pax7. Moreover, if one envisions translating iPS cells to the clinic, one has to demonstrate that functional myogenic ..
  11. Charlotte A Peterson; Fiscal Year: 2016
    ..Using the Pax7-DTA mouse, which enables inducible satellite cell ablation in response to tamoxifen (developed in the parental ..
  12. Chen Ming Fan; Fiscal Year: 2016
    ..We propose to use a knock-in allele replacing Pax7 with the Cre-ERT2 fusion gene (the Pax7CE allele) for tamoxifen (tmx) inducible cell lineage tracing in following ..
  13. Esther E Dupont-Versteegden; Fiscal Year: 2014
    ..We are in the unique position to test the role of satellite cells in diaphragm muscle with aging using the Pax7-DTA mouse, which allows for temporal and specific control of satellite cell ablation;we showed previously that >..
  14. Denis C Guttridge; Fiscal Year: 2016
    ..repair damaged fibers, but this differentiation program is blocked due to deregulation of the self-renewing factor, Pax7. The goal of this application is to explore the hypothesis that events occurring outside the myofiber are not ..
  15. Michelle Rozo; Fiscal Year: 2014
    ..I propose to define the role of b1-integrin in these processes by using a Pax7-Cre-ERT2 fusion gene (the Pax7CE allele) for tamoxifen (tmx) inducible gene inactivation of a conditional allele of ..
  16. Jen Sheen; Fiscal Year: 2016
    ..mediates glucose signaling without its metabolic activity, and interacts with two HXK1 Unconventional Partners (HUP1: a scaffolding protein interacting with HXK1, HUP2 and transcription factors (TFs);HUP2: an ATPase interacting with ..
  17. A Cis-regulatory Model for Neural Border Induction
    Daniel Meulemans Medeiros; Fiscal Year: 2013
    ..these possibilities, we are characterizing 8 evolutionarily conserved cis-regulatory elements (CREs) from the Pax3, Pax7, Zic2/5, Zic3/6 and tfap2a loci that recapitulate early neural border expression of these genes...
  18. Michael Kyba; Fiscal Year: 2016
    ..We further show that these responses involve competition with Pax7, a transcription factor at the apex of the myogenic hierarchy with a highly related homeodomain...
  19. Pax genes in cardiac development
    ZACHARY PAUL NEEB; Fiscal Year: 2012
    ..In contrast, mouse Pax7 (Pax3 paralogue) expression is first detected following neural tube closure (~E8...
  20. Bradley B Olwin; Fiscal Year: 2016
    ..When prospectively isolated, Syndecan-4+/Jam-B+ cultures maintain Pax7 expressing "reserve" cells while Pax7 is not detectable in Syndecan-4+Jam-B- satellite cell ex- plants, which all ..
  21. THE ONCOGENICITY OF WINGED HELIX PROTEINS
    Peter Vogt; Fiscal Year: 2003
    ..a mutant form of the chicken homolog of mesenchyme forkhead protein, and the human fusion proteins PAX3-FKHR and PAX7-FKHR, the putative causes of alveolar rhabdomyosarcoma...
  22. Conditional Mouse Model of Alveolar Rhabdomyosarcoma
    Charles Keller; Fiscal Year: 2006
    ..the translocation-mediated fusion of a developmentally regulated Pax transcription factor (either Pax3 or Pax7) to the Forkhead transcription factor, Fkhr...
  23. Mechanisms of Testosterone Effects on Body Composition
    Shalendar Bhasin; Fiscal Year: 2007
    ..surgical orchiectomy without and with testosterone replacement on the number of mesenchymal precursor cells (CD34+, Pax7), satellite cells (CD34+, Pax7+, located inside the basal lamina), and number of donor cells fused with muscle ..
  24. Continual addition of posterior tail segments, regeneration and Hox gene expressi
    JANET VAGLIA; Fiscal Year: 2009
    ..Investigate somitogenesis (segmentation) and expression of select early axial tissue markers (type II collagen and Pax7) across life stages in a non-model salamander that exhibits continual elongation of the tail. 3...
  25. IRSG LABORATORY CORRELATIVE STUDIES
    FREDERIC BARR; Fiscal Year: 1999
    ..The distinction between the subtypes is strengthened by molecular studies that identified PAX3/PAX7-FKHR gene fusions in alveolar RMS and allelic loss of chromosomal region 11p15.5 in embryonal RMS...
  26. The CXCR4-SDF-1 Axis in Metastatic Rhabdomyosarcoma
    Mariusz Ratajczak; Fiscal Year: 2009
    ..Since in RMS cell lines the expression of CXCR4 correlates with alveolar RMS and expression of the PAX3-FKHR and PAX7-FKHR genes, we will investigate whether PAX genes directly regulate CXCR4 expression in RMS cells...
  27. Manipulation of Prenatal Stem Cell Transplant Biology
    Aziz Merchant; Fiscal Year: 2004
    ..These signals include transcription factors, such as Pax7, which have been shown to orchestrate specification of muscle progenitors towards satellite cells and other ..
  28. COG studies of gene amplification in rhabdomyosarcoma
    FREDERIC BARR; Fiscal Year: 2009
    ..abstract_text> ..
  29. REGULATION OF PAX3/PAX7 EXPRESSION IN RHABDOMYOSARCOMA
    FREDERIC BARR; Fiscal Year: 2001
    DESCRIPTION: (adapted from the investigator's abstract) PAX3 and PAX7 are closely related members of the paired box family of transcription factors...
  30. Studies of the t(2;13) of alveolar rhabdomyosarcoma
    FREDERIC BARR; Fiscal Year: 2007
    ..These events juxtapose PAX3 or PAX7 with FKHR to create fusion genes encoding PAX3-FKHR or PAX7-FKHR fusion products...
  31. Cancer Molecular Pathology Training Program
    FREDERIC BARR; Fiscal Year: 2006
    ....
  32. IRSG STUDIES OF ALVEOLAR RHABDOMYOSARCOMA GENE FUSIONS
    FREDERIC BARR; Fiscal Year: 2005
    ..This cancer is associated with 2;13 and 1;13 chromosomal translocations that juxtapose the PAX3 and PAX7 loci with the FKHR locus to create chimeric genes encoding PAX3-FKHR or PAX7-FKHR fusion products...
  33. Satellite Cells and Skeletal Muscle Growth Dynamics
    Zipora Yablonka Reuveni; Fiscal Year: 2008
    ..The proposed investigation will contribute to a better understanding of satellite cell dynamics and muscle growth, and can prove important for muscle rehabilitation strategies during disease and aging. ..
  34. MINERALIZATION OF PRIMARY BONE
    JEFFREY GORSKI; Fiscal Year: 2008
    ..Results of this work should better define the differences between primariy and lamellar bone, as well as aid in the diagnosis and treatment of osteoporosis and atherosclerosis. ..
  35. BAG-75: UNIQUE MARKER OF PRIMARY BONE FORMATION
    JEFFREY GORSKI; Fiscal Year: 2003
    ..Stimulation of appositional formation by lamellar bone would not be expected to have the same effect. These future functional studies require determination of the BAG-75 cDNA sequence. ..
  36. Muscle and Bone Maintenance in Hindlimb Suspended Rats
    Charlotte Peterson; Fiscal Year: 2006
    ..Together, results may provide insight into the use of resistance exercise as a countermeasure to the loss of muscle and bone that occurs during space flight. ..
  37. DEK EFFECTS ON GROWTH OF HEMATOPOIETIC CELLS
    Gerard Grosveld; Fiscal Year: 2002
    ..The investigators state that these studies will provide valuable insights into the normal functions of DEK and generate important information on how DEK-CAN contributes to leukemogenesis. ..
  38. MOLECULAR ANALYSIS OF MYOTONIC DYSTROPHY
    SATYAKAM BHAGWATI; Fiscal Year: 2002
    ..This approach is designed to explore the function of these CTG/CUG repeat binding proteins and their possible role in the pathogenesis of DM. ..
  39. MYOD AND MYOGENIN IN MUSCLE HYPERTROPHY AND SARCOPENIA
    STEPHEN ALWAY; Fiscal Year: 2001
    ....
  40. LBX2 AND UROGENITAL DEVELOPMENT
    Jonathan Epstein; Fiscal Year: 2002
    ....
  41. Disease and Continuous Myofiber Remodeling in EOM
    Linda McLoon; Fiscal Year: 2004
    ..Ultimately, we hope to use this information to develop new therapeutic strategies.for the treatment of strabismus and other ocular and non-ocular muscle diseases. ..
  42. Molecular Mechanisms Regulating Stem Cell Plasticity
    Michael Rudnicki; Fiscal Year: 2004
    ..Our laboratory has identified the paired box transcription factor Pax7 as being required for the specification of myogenic satellite cells from progenitor adult satellite cells...
  43. Determinants of Bone Strength in Afro-Caribbean Families
    Joseph Zmuda; Fiscal Year: 2004
    ..The identification of these genes will likely yield fundamental insight on bone biology and may lead to the development of novel approaches to the diagnosis, treatment, and prevention of osteoporosis. ..
  44. ROLE OF MYOSTATIN IN CACHEXIA
    Se Jin Lee; Fiscal Year: 2005
    ..abstract_text> ..
  45. Dysregulation of Type I interferon in human SLE
    Lynda Bennett; Fiscal Year: 2005
    ..Thus, the studies proposed here will provide insights into mechanisms of IFN action in SLE as well as invaluable information necessary for developing tools to block the excess of type 1 IFN as novel therapy in SLE. ..
  46. 2005 NNFF Consortium for NF1, NF2 and Schwannomatosis
    Jonathan Epstein; Fiscal Year: 2005
    ....
  47. PAX3 REGULATION OF CARDIAC CONOTRUNCAL DEVELOPMENT
    Jonathan Epstein; Fiscal Year: 2008
    ..Aim 3 examines the role of neural crest during development of the conduction system, and specifically examines Pax3 regulation of DCT. [unreadable] [unreadable]..
  48. Selecting for novel Hedgehog signaling mutations
    STEPHEN DEVOTO; Fiscal Year: 2006
    ..In addition, these mutations will identify genes that are likely to play important roles in the development of human cancer. ..
  49. Characterization of myostatin and GDF-11
    Se Jin Lee; Fiscal Year: 2007
    ..abstract_text> ..
  50. Id2 REGULATION OF MUSCLE HYPERTROPHY IN AGING
    STEPHEN ALWAY; Fiscal Year: 2007
    ..abstract_text> ..
  51. Bone Strength Phenotypes in men: Genes and Environment
    Joseph Zmuda; Fiscal Year: 2008
    ..The improved understanding of the genetic regulation of bone strength that will emerge from the proposed project will yield fundamental insight into the basic mechanisms of male osteoporosis. ..
  52. Changes in myogenic progenitor potential with age
    Charlotte A Peterson; Fiscal Year: 2010
    ..Using this information, rational new strategies for frailty prevention can be designed and tested. ..
  53. Role of MN1-TEL and MN1 in Leukemogenesis
    Gerard C Grosveld; Fiscal Year: 2010
    ..These studies should also provide leads for the development of novel therapies for AML involving these transcription factors. ..
  54. International Consortium to Identify Genes and Interactions Controlling Oral Clef
    Terri Beaty; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  55. Molecular basis of vascular heterogenity and function
    Jonathan Epstein; Fiscal Year: 2008
    ..abstract_text> ..