PANE1

Summary

Gene Symbol: PANE1
Description: centromere protein M
Alias: C22orf18, CENP-M, PANE1, centromere protein M, interphase centromere complex protein 39, proliferation-associated nuclear element protein 1
Species: human

Top Publications

  1. ncbi Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells
    Hiroshi Izuta
    Bioscience and Biotechnology Center, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    Genes Cells 11:673-84. 2006
  2. ncbi The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells
    Brian Bierie
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 8, Room 101, Bethesda, MD 20892 0822, USA
    Gene Expr Patterns 4:389-95. 2004
  3. pmc Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile
    Cristina Oliveras-Ferraros
    Metabolism and Cancer Group Translational Research Laboratory Catalan Institute of Oncology Girona ICO Girona Girona, Spain Molecular Oncology Girona Biomedical Research Institute IDIBGi Girona, Spain
    Cell Cycle 13:1132-44. 2014
  4. pmc The pseudo GTPase CENP-M drives human kinetochore assembly
    Federica Basilico
    Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    elife 3:e02978. 2014
  5. pmc The CENP-T C-terminus is exclusively proximal to H3.1 and not to H3.2 or H3.3
    Christian Abendroth
    Molecular Biology, Fritz Lipmann Institute, Beutenbergstr 11, D 07745 Jena, Germany
    Int J Mol Sci 16:5839-63. 2015
  6. pmc New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
    Momoko Horikoshi
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
    Nat Genet 45:76-82. 2013
  7. doi Multicenter analyses demonstrate significant clinical effects of minor histocompatibility antigens on GvHD and GvL after HLA-matched related and unrelated hematopoietic stem cell transplantation
    Eric Spierings
    Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Blood Marrow Transplant 19:1244-53. 2013
  8. doi Minor H antigen matches and mismatches are equally distributed among recipients with or without complications after HLA identical sibling renal transplantation
    M P Dierselhuis
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Tissue Antigens 82:312-6. 2013
  9. ncbi Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin
    Jean Pierre Renou
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 22:4594-610. 2003
  10. pmc The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL
    Anthony G Brickner
    Department of Medicine, Unviersity of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, PA, USA
    Blood 107:3779-86. 2006

Research Grants

  1. A1 REGULATED LEUKOCYTE APOPTOSIS DURING INFLAMMATION
    Michael Prystowsky; Fiscal Year: 2001
  2. Proteomic analysis of head & neck squamous cell cancer
    Michael Prystowsky; Fiscal Year: 2005

Scientific Experts

  • Christian Abendroth
  • Michael B Prystowsky
  • Cristina Oliveras-Ferraros
  • Federica Basilico
  • Momoko Horikoshi
  • Eric Spierings
  • M P Dierselhuis
  • Marinela Perpelescu
  • Brian Bierie
  • Honggang Huang
  • D Hellwig
  • Tatsuo Fukagawa
  • Daniel R Foltz
  • John R Yates
  • Anthony G Brickner
  • Masahiro Okada
  • Hiroshi Izuta
  • Lothar Hennighausen
  • Jean Pierre Renou
  • Elisabet Cuyàs
  • Daniel Prumbaum
  • Alfonso Valencia
  • Stefano Maffini
  • Anna De Antoni
  • Ingrid R Vetter
  • Stefan Raunser
  • Esther Rodríguez-Gallego
  • Alejandro Vazquez-Martin
  • Ana M Rojas
  • Bruna Corominas-Faja
  • Andrea Musacchio
  • John R Weir
  • Suzan van Gerwen
  • Javier A Menendez
  • Beate Voss
  • Veronica Krenn
  • Lucia Massimiliano
  • Jorge Joven
  • Salvador Fernández-Arroyo
  • Franz Herzog
  • Sadasivam Jeganathan
  • Begoña Martin-Castillo
  • Tomasz Zimniak
  • Sebastiano Pasqualato
  • Berthold Hocher
  • Vasiliki Lagou
  • David M Evans
  • Colin A G Boreham
  • Vincent W V Jaddoe
  • David Laurin
  • Philippe Froguel
  • Sylvain Sebert
  • Ehm Astrid Andersson
  • Hazel M Inskip
  • Carla M T Tiesler
  • Anthony J Fulford
  • Inga Prokopenko
  • Neil R Robertson
  • Nicole M Warrington
  • M J Moreno
  • Timo A Lakka
  • W Burlingham
  • Christina Kanaka-Gantenbein
  • Mark I McCarthy
  • Seang Mei Saw
  • Karen A Jameson
  • Branwen J Hennig
  • Jonathan P Bradfield
  • E Campos
  • Wieland Kiess
  • Stella Santarone
  • Jorma S Viikari
  • S Teper
  • Noemi Pereira
  • Eric Borst
  • Johan G Eriksson
  • Miroslaw Markiewicz
  • D Latinne
  • Craig E Pennell
  • Fowzan S Alkuraya
  • Urszula Siekiera
  • W Weimar
  • Rany M Salem
  • Machteld Oudshoorn
  • M Tilanus
  • Harry Dolstra
  • J Alberu
  • Fatma Oguz
  • Ken K Ong
  • G Opelz

Detail Information

Publications16

  1. ncbi Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells
    Hiroshi Izuta
    Bioscience and Biotechnology Center, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    Genes Cells 11:673-84. 2006
    ..These results suggest that the seven components of the ICEN complex are predominantly localized at the centromeres and are required for kinetochore function perhaps through or not through loading of CENP-H and hMis6 onto the centromere...
  2. ncbi The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells
    Brian Bierie
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 8, Room 101, Bethesda, MD 20892 0822, USA
    Gene Expr Patterns 4:389-95. 2004
    The proliferation associated nuclear element (PANE1) had been identified in a screen for genes activated in mouse mammary epithelium transformed by stabilized beta-catenin...
  3. pmc Acquired resistance to metformin in breast cancer cells triggers transcriptome reprogramming toward a degradome-related metastatic stem-like profile
    Cristina Oliveras-Ferraros
    Metabolism and Cancer Group Translational Research Laboratory Catalan Institute of Oncology Girona ICO Girona Girona, Spain Molecular Oncology Girona Biomedical Research Institute IDIBGi Girona, Spain
    Cell Cycle 13:1132-44. 2014
    ....
  4. pmc The pseudo GTPase CENP-M drives human kinetochore assembly
    Federica Basilico
    Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    elife 3:e02978. 2014
    ..Our studies identify a single pathway having CENP-C as founder, and CENP-H/I/K/M and CENP-T/W as CENP-C-dependent followers.DOI: http://dx.doi.org/10.7554/eLife.02978.001. ..
  5. pmc The CENP-T C-terminus is exclusively proximal to H3.1 and not to H3.2 or H3.3
    Christian Abendroth
    Molecular Biology, Fritz Lipmann Institute, Beutenbergstr 11, D 07745 Jena, Germany
    Int J Mol Sci 16:5839-63. 2015
    ..1-containing centromeric nucleosome. They also indicate an exclusive position of H3.1 clearly distinct from H3.2, thus documenting a local, and potentially also functional, difference between H3.1 and H3.2...
  6. pmc New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
    Momoko Horikoshi
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
    Nat Genet 45:76-82. 2013
    ..Our findings highlight genetic links between fetal growth and postnatal growth and metabolism...
  7. doi Multicenter analyses demonstrate significant clinical effects of minor histocompatibility antigens on GvHD and GvL after HLA-matched related and unrelated hematopoietic stem cell transplantation
    Eric Spierings
    Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Blood Marrow Transplant 19:1244-53. 2013
    ..recipient DNA samples were genotyped for the minor H antigens HA-1, HA-2, HA-3, HA-8, HB-1, ACC-1, ACC-2, SP110, PANE1, UGT2B17, and HY...
  8. doi Minor H antigen matches and mismatches are equally distributed among recipients with or without complications after HLA identical sibling renal transplantation
    M P Dierselhuis
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Tissue Antigens 82:312-6. 2013
    ..and donor DNA samples were genotyped for the minor H antigens HA-1, HA-2, HA-3, HA-8, HB-1, ACC-1, ACC-2, SP110, PANE1, UGT2B17, C19Orf48, LB-ECGF-1, CTSH, LRH-1, LB-ADIR and HY...
  9. ncbi Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin
    Jean Pierre Renou
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 22:4594-610. 2003
    ..A new 20 kDa protein (PANE1) induced upon transdifferentiation was nuclear in nonconfluent cells and cytoplasmic in confluent or dividing ..
  10. pmc The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL
    Anthony G Brickner
    Department of Medicine, Unviersity of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, PA, USA
    Blood 107:3779-86. 2006
    ..Here we report that an alternative transcript of the proliferation-associated nuclear element 1 (PANE1) gene encodes a novel human leukocyte antigen (HLA)-A(*)0301-restricted mHAg that is selectively expressed in B-..
  11. ncbi The human CENP-A centromeric nucleosome-associated complex
    Daniel R Foltz
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093 0670, USA
    Nat Cell Biol 8:458-69. 2006
    ..The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling...
  12. ncbi The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres
    Masahiro Okada
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Nat Cell Biol 8:446-57. 2006
    ....
  13. doi The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines
    Michael B Prystowsky
    Department of Pathology, Albert Einstein College of Medicine and Montefiore Medical Center, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Pathol 218:467-77. 2009
    ....
  14. doi Acceptor-photobleaching FRET analysis of core kinetochore and NAC proteins in living human cells
    D Hellwig
    Department of Molecular Biology, Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, Germany
    Eur Biophys J 38:781-91. 2009
    ..The data indicate that CENP-U is in close vicinity to CENP-I as well as to CENP-B and that CENP-M is close to CENP-T...
  15. doi Molecular characterization and association analysis of porcine PANE1 gene
    Honggang Huang
    Key Laboratory for Farm Animal Genetic Resources and Utilization of Ministry of Agriculture of China, Institute of Animal Science, Chinese Academy of Agricultural Sciences, 100193 Beijing, China
    Mol Biol Rep 37:2571-7. 2010
    The proliferation associated nuclear element 1 (PANE1) is a novel gene that is involved in immune response besides its primary role in centromere assembly...
  16. doi The ABCs of CENPs
    Marinela Perpelescu
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka, Japan
    Chromosoma 120:425-46. 2011
    ..This review presents discussion of the latest structural and functional data on CENP-A and CENPs from the CCAN as well as their interaction with the KMN network...

Research Grants2

  1. A1 REGULATED LEUKOCYTE APOPTOSIS DURING INFLAMMATION
    Michael Prystowsky; Fiscal Year: 2001
    ..3) Protection of macrophages during inflammation is mediated by A1 and is vital for host defense. ..
  2. Proteomic analysis of head & neck squamous cell cancer
    Michael Prystowsky; Fiscal Year: 2005
    ....