p75NTR

Summary

Gene Symbol: p75NTR
Description: nerve growth factor receptor
Alias: CD271, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR, tumor necrosis factor receptor superfamily member 16, NGF receptor, TNFR superfamily, member 16, low affinity neurotrophin receptor p75NTR, low-affinity nerve growth factor receptor, p75 ICD
Species: human

Top Publications

  1. ncbi Monoclonal antibodies to the cell surface and a soluble form of the human nerve growth factor receptor
    M Clagett Dame
    School of Pharmacy, University of Wisconsin Madison
    J Neurosci Res 27:642-50. 1990
  2. ncbi Structures of the extracellular domain of the type I tumor necrosis factor receptor
    J H Naismith
    Centre for Biomolecular Sciences, Purdie Building, The University, St Andrews, KY16 9ST, Scotland, UK
    Structure 4:1251-62. 1996
  3. ncbi Cholinergic medial septum neurons do not degenerate in aged 129/Sv control or p75(NGFR)-/-mice
    N L Ward
    Department of Anatomy and Neurobiology, Tupper Building, Dalhousie University, Halifax, N S, Canada
    Neurobiol Aging 21:125-34. 2000
  4. ncbi Enhanced expression of tyrosine kinase receptor a in germ cells of rat testis with acute experimental testicular torsion
    Changjong Moon
    Department of Veterinary Medicine, Cheju National University, Jeju, South Korea
    Urol Int 74:79-85. 2005
  5. ncbi [Biocompatibility of silk fibroin nanofibers scaffold with olfactory ensheathing cells]
    Yuqiang Qian
    Department of Orthopedics, Second Affiliated Hospital, Soochow University, Suzhou Jiangsu 215004, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23:1365-70. 2009
  6. ncbi Functional cooperation between TrkA and p75(NTR) accelerates neuronal differentiation by increased transcription of GAP-43 and p21(CIP/WAF) genes via ERK1/2 and AP-1 activities
    Daniel Diolaiti
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Exp Cell Res 313:2980-92. 2007
  7. ncbi MyD88, an adapter protein involved in interleukin-1 signaling
    K Burns
    Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
    J Biol Chem 273:12203-9. 1998
  8. ncbi 14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction
    M T Kimura
    Molecular Oncology Laboratory, Tsukuba Institute, RIKEN Institute of Physical and Chemical Research, Ibaraki 305 0074, Japan
    J Biol Chem 276:17291-300. 2001
  9. ncbi Nerve growth factor promotes TLR4 signaling-induced maturation of human dendritic cells in vitro through inducible p75NTR 1
    Yingming Jiang
    Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai, People s Republic of China
    J Immunol 179:6297-304. 2007
  10. ncbi Gene transfer and molecular cloning of the human NGF receptor
    M V Chao
    Science 232:518-21. 1986

Research Grants

  1. Evaristus A Nwulia; Fiscal Year: 2015
  2. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2011
  3. Factors Responsible for Cardiac Preservation Conferred by Adult Marrow Stem Cells
    Jeffrey L Spees; Fiscal Year: 2012
  4. NERVE GROWTH FACTOR RECEPTOR MEDIATED TRANSPORT TOPICS
    John Schweitzer; Fiscal Year: 1991
  5. NERVE GROWTH FACTOR
    Mark Bothwell; Fiscal Year: 1991
  6. NERVE GROWTH FACTOR RECEPTOR--A MOLECULAR ANALYSIS
    Barbara Hempstead; Fiscal Year: 1990
  7. Huaxi Xu; Fiscal Year: 2016
  8. Estrogenic-cholinergic interactions in memory modulation
    KARYN FRICK; Fiscal Year: 2004
  9. Sphingosine 1 Phosphate Receptor and Neurite Retraction
    Rachelle Toman; Fiscal Year: 2003
  10. PATHOLOGY IN ALZHEIMER'S DISEASE
    Gerald Higgins; Fiscal Year: 1990

Detail Information

Publications246 found, 100 shown here

  1. ncbi Monoclonal antibodies to the cell surface and a soluble form of the human nerve growth factor receptor
    M Clagett Dame
    School of Pharmacy, University of Wisconsin Madison
    J Neurosci Res 27:642-50. 1990
    ..The 2-site RISA can be used to rapidly quantitate NGF-R and NGF-Rt in large numbers of biological samples in the absence of added [125-I]-labeled NGF...
  2. ncbi Structures of the extracellular domain of the type I tumor necrosis factor receptor
    J H Naismith
    Centre for Biomolecular Sciences, Purdie Building, The University, St Andrews, KY16 9ST, Scotland, UK
    Structure 4:1251-62. 1996
    ..Two TNF receptors that belong to the cysteine-rich low affinity nerve growth factor receptor family (TNF-R1 and TNF-R2) are the sole mediators of TNF signalling...
  3. ncbi Cholinergic medial septum neurons do not degenerate in aged 129/Sv control or p75(NGFR)-/-mice
    N L Ward
    Department of Anatomy and Neurobiology, Tupper Building, Dalhousie University, Halifax, N S, Canada
    Neurobiol Aging 21:125-34. 2000
    ..Alternatively, p75(NGFR) -/- mice may have developed compensatory mechanisms in response to the absence of p75(NGFR)...
  4. ncbi Enhanced expression of tyrosine kinase receptor a in germ cells of rat testis with acute experimental testicular torsion
    Changjong Moon
    Department of Veterinary Medicine, Cheju National University, Jeju, South Korea
    Urol Int 74:79-85. 2005
    ..Apoptosis was detected using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) method...
  5. ncbi [Biocompatibility of silk fibroin nanofibers scaffold with olfactory ensheathing cells]
    Yuqiang Qian
    Department of Orthopedics, Second Affiliated Hospital, Soochow University, Suzhou Jiangsu 215004, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23:1365-70. 2009
    ..To investigate the biocompatibility of silk fibroin nanofibers scaffold with olfactory ensheathing cells (OECs) and to provide an ideal tissue engineered scaffold for the repair of spinal cord injury (SCI)...
  6. ncbi Functional cooperation between TrkA and p75(NTR) accelerates neuronal differentiation by increased transcription of GAP-43 and p21(CIP/WAF) genes via ERK1/2 and AP-1 activities
    Daniel Diolaiti
    Department of Biology, University of Bologna, Via Selmi 3, 40126 Bologna, Italy
    Exp Cell Res 313:2980-92. 2007
    ....
  7. ncbi MyD88, an adapter protein involved in interleukin-1 signaling
    K Burns
    Institute of Biochemistry, Lausanne Branch, University of Lausanne, Switzerland
    J Biol Chem 273:12203-9. 1998
    ..MyD88 coimmunoprecipitates with the IL-1R signaling complex in an IL-1-dependent manner...
  8. ncbi 14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction
    M T Kimura
    Molecular Oncology Laboratory, Tsukuba Institute, RIKEN Institute of Physical and Chemical Research, Ibaraki 305 0074, Japan
    J Biol Chem 276:17291-300. 2001
    The low affinity neurotrophin receptor (p75NTR) has been shown to mediate the apoptosis signaling to neural cells. However, the specific mechanisms of intracellular signal transduction of this process are largely unknown...
  9. ncbi Nerve growth factor promotes TLR4 signaling-induced maturation of human dendritic cells in vitro through inducible p75NTR 1
    Yingming Jiang
    Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai, People s Republic of China
    J Immunol 179:6297-304. 2007
    ....
  10. ncbi Gene transfer and molecular cloning of the human NGF receptor
    M V Chao
    Science 232:518-21. 1986
    ..Mouse L cell transformants have been generated that stably express the human NGF receptor gene transfer with total human DNA...
  11. ncbi Expression and structure of the human NGF receptor
    D Johnson
    Cell 47:545-54. 1986
    ..The sequence of the extracellular domain of the NGF receptor predicts a highly ordered structure containing a negatively charged region that may serve as the ligand-binding ..
  12. ncbi Association of the p75 neurotrophin receptor with TRAF6
    G Khursigara
    Molecular Neurobiology Program, Skirball Institute, New York University Medical Center, 540 New York, New York 10016, USA
    J Biol Chem 274:2597-600. 1999
    ..These results indicate that TRAF6 can potentially function as a signal transducer for NGF actions through the p75 receptor...
  13. pmc Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR
    M Bibel
    Max Planck Institute of Neurobiology, Department of Neurobiochemistry, 82152 Planegg Martinsried, Germany
    EMBO J 18:616-22. 1999
    ..These results indicate a close proximity of the two neurotrophin receptors within cell membranes, and suggest that the signalling pathways they initiate may interact soon after their activation...
  14. ncbi TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction
    X Ye
    The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 274:30202-8. 1999
    ..These results demonstrate that TRAF family proteins interact with p75(NTR) and differentially modulate its NF-kappaB activation and cell death induction...
  15. ncbi Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation
    S Irie
    Molecular Oncology Laboratory, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    FEBS Lett 460:191-8. 1999
    ..Thus, FAP-1 may regulate p75(NTR)-mediated signal transduction by physiological interaction through its third PDZ domain...
  16. pmc The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death
    E Casademunt
    Department of Neurobiochemistry, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
    EMBO J 18:6050-61. 1999
    ..These results indicate that NRIF is an intracellular p75(NTR)-binding protein transducing cell death signals during development...
  17. ncbi Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth
    T Yamashita
    Department of Neurobiochemistry, Max Planck Institute of Neurobiology, Martinsried, Federal Republic of Germany
    Neuron 24:585-93. 1999
    While the neurotrophin receptor p75NTR is expressed by many developing neurons, its function in cells escaping elimination by programmed cell death remains unclear...
  18. ncbi NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR
    J Mukai
    Molecular Oncology Laboratory, Tsukuba Life Science Center, RIKEN Institute of Physical and Chemical Research, Ibaraki 305 0074, Japan
    J Biol Chem 275:17566-70. 2000
    The low affinity neurotrophin receptor p75NTR can mediate cell survival as well as cell death of neural cells by NGF and other neurotrophins...
  19. ncbi Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration
    A E Fournier
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 409:341-6. 2001
    ..Nogo-66 receptor expression is sufficient to impart Nogo-66 axonal inhibition to unresponsive neurons. Disruption of the interaction between Nogo-66 and its receptor provides the potential for enhanced recovery after human CNS injury...
  20. ncbi A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2
    G Khursigara
    Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 21:5854-63. 2001
    ..These results indicate that adaptor proteins like RIP2 can provide a bifunctional switch for cell survival or cell death decisions mediated by the p75 neurotrophin receptor...
  21. ncbi Regulation of cell survival by secreted proneurotrophins
    R Lee
    Division of Hematology, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Science 294:1945-8. 2001
    ..ProNGF is a high-affinity ligand for p75(NTR) with high affinity and induced p75NTR-dependent apoptosis in cultured neurons with minimal activation of TrkA-mediated differentiation or survival...
  22. pmc The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho
    Toshihide Yamashita
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Cell Biol 157:565-70. 2002
    ..Ganglioside GT1b, which is one of the binding partners of MAG, specifically associates with p75(NTR). Thus, p75(NTR) and GT1b may form a receptor complex for MAG to transmit the inhibitory signals in neurons...
  23. ncbi The p75 neurotrophin receptor interacts with multiple MAGE proteins
    Marianna Tcherpakov
    Molecular Neurobiology Group, Department of Biological Chemistry, Weizmann Institute of Science, 76100 Rehovot, Israel
    J Biol Chem 277:49101-4. 2002
    ..These findings indicate that diverse MAGE family members can interact with the p75 receptor and highlight type II MAGE proteins as a potential family of interactors for signaling proteins containing type II death domains...
  24. ncbi P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp
    Kevin C Wang
    Division of Neuroscience, Children s Hospital and Program in Neuroscience, Harvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 420:74-8. 2002
    ..Thus, interfering with p75 and its downstream signalling pathways may allow lesioned axons to overcome most of the inhibitory activities associated with central nervous system myelin...
  25. ncbi A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein
    Scott T Wong
    Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nat Neurosci 5:1302-8. 2002
    ..Thus we conclude that p75(NTR) is a co-receptor of NgR for MAG signaling and a potential therapeutic target for promoting nerve regeneration...
  26. ncbi The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI
    Toshihide Yamashita
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nat Neurosci 6:461-7. 2003
    ..This peptide has potential as a therapeutic agent against the inhibitory cues that block regeneration in the central nervous system...
  27. ncbi Neurotrophin receptor p75(NTR) characterizes human esophageal keratinocyte stem cells in vitro
    Tomoyuki Okumura
    Laboratory of Molecular Cell Biology and Oncology, Kanagawa Cancer Center Research Institute, 1 1 2 Nakao, Asahi ku, Yokohama 241 0815, Japan
    Oncogene 22:4017-26. 2003
    ....
  28. ncbi Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability
    Kevin C Kanning
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 23:5425-36. 2003
    The 75 kDa neurotrophin receptor (p75NTR) and two neurotrophin receptor homologs (NRH1, NRH2) constitute a subfamily of the nerve growth factor/tumor necrosis factor receptor superfamily...
  29. ncbi Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS
    Marie T Filbin
    Department of Biological Sciences, Hunter College, City University of New York, 695 Park Avenue, New York, New York 10021, USA
    Nat Rev Neurosci 4:703-13. 2003
  30. ncbi A functional interaction between the p75 neurotrophin receptor interacting factors, TRAF6 and NRIF
    Jennifer J Gentry
    Department of Biochemistry and Center for Molecular Neuroscience, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    J Biol Chem 279:16646-56. 2004
    ..These results suggest that NRIF and TRAF6 functionally interact to facilitate neurotrophin signaling through the p75 receptor...
  31. ncbi LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex
    Sha Mi
    Department of Discovery Biology, Biogen Idec, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Neurosci 7:221-8. 2004
    ..This effect on neurons was mimicked using an exogenously added human LINGO-1-Fc fusion protein. Together these observations suggest that LINGO-1 has an important role in CNS biology...
  32. ncbi Sortilin is essential for proNGF-induced neuronal cell death
    Anders Nykjaer
    Department of Medical Biochemistry, Ole Worms Alle 170, Aarhus University, Gustav Wieds Vej 10, DK 8000 Aarhus C, Denmark
    Nature 427:843-8. 2004
    ..NGF regulates cell survival and cell death via binding to two different receptors, TrkA and p75NTR (ref. 10). In contrast, proNGF selectively induces apoptosis through p75NTR but not TrkA...
  33. ncbi A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors
    Jong Bae Park
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 45:345-51. 2005
    ..Our results implicate TROY in mediating myelin inhibition, offering new insights into the molecular mechanisms of regeneration failure in the adult nervous system...
  34. ncbi p75NTR--live or let die
    Anders Nykjaer
    Department of Medical Biochemistry, Ole Worms Allé Building 170, Aarhus University, DK 8000C Aarhus, Denmark
    Curr Opin Neurobiol 15:49-57. 2005
    ..Here, we review recent progress in delineating the molecular networks that enable p75(NTR) to dictate life and death...
  35. ncbi Characterization of the signaling pathway downstream p75 neurotrophin receptor involved in beta-amyloid peptide-dependent cell death
    Claudio Costantini
    Department of Pathology, Section of General Pathology, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    J Mol Neurosci 25:141-56. 2005
    ..Previous studies have shown that Abeta peptide can damage neurons by activating the p75 neurotrophin receptor (p75NTR). However, the signaling pathway leading to neuronal cell death is not completely understood...
  36. ncbi Increased nerve growth factor and its receptors in atopic dermatitis: an immunohistochemical study
    Ying Chun Dou
    Experimental Dermatology Unit, Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden
    Arch Dermatol Res 298:31-7. 2006
    ..These findings indicate that NGF and its receptors may contribute to the neurohyperplasia of AD...
  37. ncbi The biological role of the low-affinity p75 neurotrophin receptor in esophageal squamous cell carcinoma
    Tomoyuki Okumura
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Clin Cancer Res 12:5096-103. 2006
    In this study, we investigated the clinicopathologic significance of the low-affinity p75 neurotrophin receptor (p75NTR; which is expressed in the stem/progenitor cell fraction of normal esophageal epithelial cells) in 187 resected ..
  38. ncbi Identification of human oral keratinocyte stem/progenitor cells by neurotrophin receptor p75 and the role of neurotrophin/p75 signaling
    Takahiro Nakamura
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 0841, Japan
    Stem Cells 25:628-38. 2007
    ..Our in vivo and in vitro findings indicate that p75 is a potential marker of oral keratinocyte stem/progenitor cells and that some neurotrophin/p75 signaling affects cell growth and survival...
  39. ncbi Hypo-osmolar stress induces p75NTR expression by activating Sp1-dependent transcription
    Alberto Ramos
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 27:1498-506. 2007
    Injury-induced expression of the p75 neurotrophin receptor (p75NTR) in the CNS facilitates neuronal apoptosis and prevents neuronal regrowth, but the mechanisms regulating p75NTR expression are poorly characterized...
  40. ncbi Nerve growth factor and tissue repair remodeling: trkA(NGFR) and p75(NTR), two receptors one fate
    Alessandra Micera
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel
    Cytokine Growth Factor Rev 18:245-56. 2007
    ..In summary, these novel findings on the potential pro-healing capacity of NGF might open new possibilities for this growth factor in modulating the healing processes in several pathological conditions...
  41. ncbi CD 271 (P75 neurotrophin receptor)
    M L Rogers
    Department of Human Physiology, Centre for Neuroscience, Flinders University, South Australia
    J Biol Regul Homeost Agents 22:1-6. 2008
    b>P75NTR (or CD271) is a member of the Tumor Necrosis Factor receptor (TNFR) super family of transmembrane proteins that share significant homology in their extracellular domains...
  42. doi Nerve growth factor receptor (p75 NTR) and pattern of invasion predict poor prognosis in oral squamous cell carcinoma
    T M Søland
    Department of Pathology and Forensic Odontology, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway
    Histopathology 53:62-72. 2008
    ..The results were related to tumour node metastasis (TNM) stage, World Health Organization (WHO) grade, invasive front grading (IFG) and prognosis...
  43. pmc Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis: implications for diabetes-induced impaired neovascularization in ischemic limb muscles
    Andrea Caporali
    Experimental Cardiovascular Medicine Division, Bristol Heart Institute, University of Bristol, UK
    Circ Res 103:e15-26. 2008
    ..Collectively, our data newly demonstrate the antiangiogenic action of p75(NTR) and open new avenues for the therapeutic use of p75(NTR) inhibition to combat diabetes-induced microvascular liabilities...
  44. doi The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling
    Claire Ceni
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada
    J Cell Sci 123:2299-307. 2010
    The p75 neurotrophin receptor (p75NTR) potentiates Trk signaling, but the underlying mechanisms remain uncertain. Here, we examine the relationship between p75NTR cleavage and Trk signaling...
  45. pmc Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271
    Alexander D Boiko
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94304 5542, USA
    Nature 466:133-7. 2010
    ..tumour stem cells (MTSCs, for melanoma tumour stem cells) can be isolated prospectively as a highly enriched CD271(+) MTSC population using a process that maximizes viable cell transplantation...
  46. doi Human neurotrophin receptor p75NTR defines differentiation-oriented skeletal muscle precursor cells: implications for muscle regeneration
    Emanuela Colombo
    Neuroimmunology and Neuromuscular Disorders Unit, Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy
    J Neuropathol Exp Neurol 70:133-42. 2011
    ..Here, we analyzed the expression and function of the neurotrophin receptor p75NTR in human skeletal muscle precursor cells...
  47. doi Human CD271-positive melanoma stem cells associated with metastasis establish tumor heterogeneity and long-term growth
    Gianluca Civenni
    Institute of Anatomy and Biostatistics Unit ISPM, University of Zurich, Zurich, Switzerland
    Cancer Res 71:3098-109. 2011
    ..of neural crest derivatives and contains multipotent cells that express the neural crest stem cell markers CD271(p75(NTR)) and Sox10...
  48. doi Immunohistochemical location of the p75 neurotrophin receptor (p75NTR) in oral leukoplakia and oral squamous cell carcinoma
    Takahiro Kiyosue
    Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Int J Clin Oncol 18:154-63. 2013
    Recent studies have demonstrated that the p75 neurotrophin receptor (p75NTR) is a useful marker of keratinocyte stem cells...
  49. pmc The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretase
    Alex M Sykes
    Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia
    J Biol Chem 287:43810-24. 2012
    ..These results provide support for the idea that the helical structure of the p75(NTR) transmembrane domain, which may be affected by co-receptor interactions, is a key element in γ-secretase-catalyzed cleavage...
  50. doi Genetic dissection of neurotrophin signaling through the p75 neurotrophin receptor
    Ioannis Charalampopoulos
    Department of Neuroscience, Karolinska Institute, Stockholm 17177, Sweden
    Cell Rep 2:1563-70. 2012
    ..The p75 neurotrophin receptor (p75(NTR)), also known as TNFRSF16, is a key regulator of trophic and injury responses in the nervous system...
  51. pmc CD271 defines a stem cell-like population in hypopharyngeal cancer
    Takayuki Imai
    Division of Cancer Biology and Therapeutics, Miyagi Cancer Center Research Institute, Natori, Miyagi, Japan
    PLoS ONE 8:e62002. 2013
    ..Here, we report that the CD271(+) population sorted from xenotransplanted HPCs possesses an enhanced tumor-initiating capability in ..
  52. ncbi Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin
    Oluwatoyin Shonukan
    Department of Medicine, Division of Hematology Oncology, University of Miami School of Medicine, Miami, FL 33136, USA
    Oncogene 22:3616-23. 2003
    ..These results suggest a causal role for NGF-mediated dephosphorylation of serine 39 on fascin in mediating actin binding and subsequent melanoma cell migration...
  53. ncbi Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor
    Ken ichiro Kuwako
    Division of Regulation of Macromolecular Functions, Institute for Protein Research, Osaka University, Yamadaoka 3 2, Suita, Osaka 565 0871, Japan
    J Biol Chem 279:1703-12. 2004
    ..These results suggest that necdin and MAGE-G1 target both E2F1 and p75 to regulate cell viability during brain development...
  54. ncbi p75 neurotrophin receptor signaling regulates growth cone filopodial dynamics through modulating RhoA activity
    Scott Gehler
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 24:4363-72. 2004
    ..We investigated the role of the p75 neurotrophin receptor (p75NTR) in mediating neurotrophin-induced increases in filopodial length...
  55. doi Neurotrophins and their receptors stimulate melanoma cell proliferation and migration
    Francesca Truzzi
    Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
    J Invest Dermatol 128:2031-40. 2008
    ..Moreover, melanoma cells express the low-affinity (p75NTR) and the high-affinity tyrosine kinase NT receptors (Trk)...
  56. ncbi SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population
    Arianna Cozza
    Department of Experimental Pathology, Medical Biotechnology, Infectious Diseases and Epidemiology, University of Pisa, Pisa, Italy
    J Alzheimers Dis 15:61-70. 2008
    ..047). A trend to association with sAD and/or fAD was observed for other SNPs. Our results suggest that genetic variants of neurotrophin system genes might confer susceptibility to AD...
  57. doi Patterns of expression and function of the p75(NGFR) protein in pancreatic cancer cells and tumours
    W Wang
    Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai, PR China
    Eur J Surg Oncol 35:826-32. 2009
    ..The aim of the present study is to investigate the expression pattern and function of the p75(NGFR) protein in pancreatic cancer cell lines and tumours to explain the phenomenon of perineural invasion in pancreatic cancer...
  58. pmc Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor
    A Chittka
    Cell Biology Program, Weill Graduate School of Cornell University Medical College, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:10705-10. 1999
    ..A direct correlation between nuclear expression of SC-1 with the loss of BrdUrd incorporation was observed. These results imply that SC-1 may be involved in events associated with growth arrest...
  59. ncbi NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis
    A H Salehi
    Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, Quebec, Canada
    Neuron 27:279-88. 2000
    The mechanisms employed by the p75 neurotrophin receptor (p75NTR) to mediate neurotrophin-dependent apoptosis are poorly defined...
  60. ncbi Identification of interleukin 1 receptor-associated kinase as a conserved component in the p75-neurotrophin receptor activation of nuclear factor-kappa B
    Vidya Mamidipudi
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Biol Chem 277:28010-8. 2002
    ..Our results reveal that IRAK is recruited to the p75-NGF receptor leading to formation of a complex between IRAK, atypical protein kinase C interacting protein, p62, and TRAF6...
  61. ncbi Dissection of the translocation and chaperoning functions of yeast BiP/Kar2p in vivo
    H Holkeri
    Institute of Biotechnology, University of Helsinki, Finland
    J Cell Sci 111:749-57. 1998
    ..Apparently proteins differ in their post-translocational requirements for BiP/Kar2p, indicating that translocation and chaperoning are distinct functions...
  62. ncbi The sorting determinant guiding Hsp150 to the COPI-independent transport pathway in yeast
    T Suntio
    Institute of Biotechnology, PO Box 58, Finland
    J Cell Sci 112:3889-98. 1999
    ..Mass spectroscopic analysis demonstrated that both subunit I and II of Hsp150 were extensively O-glycosylated, suggesting that the O-glycosylation pattern was not decisive for cargo selection...
  63. ncbi Glycosylation of rat NGF receptor ectodomain in the yeast Saccharomyces cerevisiae
    H Holkeri
    Institute of Biotechnology, University of Helsinki, Finland
    FEBS Lett 383:255-8. 1996
    ..Thus, the serine and threonine residues of the hsp 150 delta-NGFRe fusion protein were highly selectively O-glycosylated...
  64. ncbi NGF-resistant PC12 cell death induced by arachidonic acid is accompanied by a decrease of active PKC zeta and nuclear factor kappa B
    N J Macdonald
    Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch at Galveston, USA
    J Neurosci Res 57:219-26. 1999
    ..Our results also suggest that AA, an inflammatory signal lipid induced by TNFalpha via binding to TNFR-I, may reduce neuronal survival by inhibiting elements of the signal cascade induced by NGF...
  65. pmc Localization of the low-affinity nerve growth factor receptor p75 in human limbal epithelial cells
    Nick Di Girolamo
    Inflammatory Diseases Research Unit, School of Medical Sciences, University of New South Wales, and Department of Ophthalmology, Prince of Wales Hospital, Sydney, NSW, Australia
    J Cell Mol Med 12:2799-811. 2008
    ..p75 may represent an additional ocular surface epithelial stem/progenitor cell signature gene...
  66. ncbi Expression and significance of nerve growth factor receptor p75 in rats' cathartic colonic wall
    Yi Hong Fan
    Department of Gastroenterology, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang Province, China
    Chin J Dig Dis 7:225-9. 2006
    ..To investigate the expression of nerve growth factor receptor p75 in a normal and cathartic colon and its significance in the formation of the cathartic colon in rats...
  67. doi Role of low-affinity nerve growth factor receptor inhibitory antibody in reducing pain behavior and calcitonin gene-related Peptide expression in a rat model of wrist joint inflammatory pain
    Nahoko Iwakura
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Hand Surg Am 35:267-73. 2010
    ..3%), and paresthesia (6.8%) were reported. We hypothesized that inhibition of the low-affinity NGF receptor, p75 neurotrophin receptor (p75NTR), is also effective for joint pain and may reduce side effects...
  68. ncbi Cellular localization of brain-derived neurotrophic factor and neurotrophin-3 mRNA expression in the early chicken embryo
    F Hallbook
    Department of Medical Chemistry, Karolinska Institute, Stockholm, Sweden
    Eur J Neurosci 5:1-14. 1993
    ..The results support the emerging view that neurotrophic factors can play a role in early differentiation of both neuronal and non-neuronal tissues...
  69. ncbi Role of nerve growth factor and its receptor in the morphogenesis of neural tube in early chick embryo
    Shobha Bhargava
    Molecular Embryology Laboratory, Department of Zoology, University of Pune, Pune 411 007, India
    Gen Comp Endocrinol 153:141-6. 2007
    ..The findings supports and confirms our previous study that NGF signaling plays a significant role in the shaping of neural tube in chick embryos through p75(NTR)-NGF receptor.
  70. pmc TrkA-immunoreactive profiles in the central nervous system: colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin
    T Sobreviela
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612
    J Comp Neurol 350:587-611. 1994
    ..These findings suggest that pharmacological use of ligands for trkA could have beneficial effects on the multiple neuronal systems that are affected in such disorders as Alzheimer's disease...
  71. ncbi Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR
    B T Fundin
    Department of Anatomy, Uppsala University, Sweden
    Dev Biol 190:94-116. 1997
    ..In the context of these findings, indications of competitive and suppressive interactions that appear to regulate the balance of innervation density among the various sets of innervation were evident...
  72. ncbi Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue
    Jorge S Reis-Filho
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Mod Pathol 19:307-19. 2006
    ..Furthermore, provisional data in a small number of basal-like breast carcinomas suggest that NGFR may identify a subgroup of basal-like breast carcinomas with good prognosis...
  73. ncbi Changes in the mRNA expression pattern, with special reference to calcitonin gene-related peptide, after axonal injuries in rat motoneurons depends on age and type of injury
    F Piehl
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Exp Brain Res 119:191-204. 1998
    ..Of the substances studied here, upregulation of alpha-CGRP and p75 mRNAs best correlated with a possibility of axon regeneration...
  74. pmc Nerve growth factor receptor TrkA is expressed by horizontal and amacrine cells during chicken retinal development
    M Karlsson
    Uppsala University, Sweden
    J Comp Neurol 400:408-16. 1998
    ..we have compared the expression of trkA mRNA with that of the 75-kD low-affinity neurotrophin receptor (p75NTR). RNase protection assay identified peak-levels of trkA mRNA in the late embryonic retina...
  75. ncbi P75 nerve growth factor receptor is important for retrograde transport of neurotrophins in adult cholinergic basal forebrain neurons
    B M Kramer
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Neuroscience 94:1163-72. 1999
    ....
  76. ncbi Neurotrophin-4/5-depletion induces a delay in maturation of the periodontal Ruffini endings in mice
    Yuko Maruyama
    Divisions of Oral Anatomy, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Arch Histol Cytol 68:267-88. 2005
    ..Furthermore, the immuno-expression of TrkB and low affinity nerve growth factor receptor (p75-NGFR) was surveyed in the periodontal Ruffini endings as well as trigeminal ganglion...
  77. doi The stromal composition of mast cell aggregates in systemic mastocytosis
    April Chiu
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Mod Pathol 22:857-65. 2009
    ....
  78. ncbi Regulatory elements and transcriptional regulation by testosterone and retinoic acid of the rat nerve growth factor receptor promoter
    M Metsis
    Department of Medical Chemistry II, Karolinska Institute, Stockholm, Sweden
    Gene 121:247-54. 1992
    ..A RA-responsive element active in PC12 cells is located between bp -610 to -860 from the start codon...
  79. ncbi TLR4 signaling induces functional nerve growth factor receptor p75NTR on mouse dendritic cells via p38MAPK and NF-kappa B pathways
    Yingming Jiang
    Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People s Republic of China
    Mol Immunol 45:1557-66. 2008
    ..acid (LTA), Poly (I:C) and CpG oligodeoxynucleotide (ODN), could significantly induce expression of NGF and NGF receptor p75(NTR) on mouse bone marrow-derived DCs (BMDCs) in vitro in dose- and time-dependent manners...
  80. ncbi Long-term multilineage expression in peripheral blood from a Moloney murine leukemia virus vector after serial transplantation of transduced bone marrow cells
    T W Austin
    SyStemix Inc, Palo Alto, CA 94304, USA
    Blood 95:829-36. 2000
    ....
  81. ncbi Mesenchymal cell precursors of peritubular smooth muscle cells of the mouse testis can be identified by the presence of the p75 neurotrophin receptor
    L Campagnolo
    Department of Public Health and Cell Biology, Section of Histology and Embryology, University of Rome Tor Vergata, Via di Tor Vergata 135, 00173 Rome, Italy
    Biol Reprod 64:464-72. 2001
    ..population of mesenchymal cells in fetal and newborn mouse testis express the p75 neurotrophin receptor (p75NTR, formerly known as the low-affinity nerve growth factor receptor); part of the cell population progressively ..
  82. doi Existence of nerve growth factor receptors, tyrosine kinase a and p75 neurotrophin receptors in intervertebral discs and on dorsal root ganglion neurons innervating intervertebral discs in rats
    Ai Sugiura
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 33:2047-51. 2008
    ..We evaluated 2 types of nerve growth factor (NGF) receptors on dorsal root ganglion (DRG) cells and nerve fibers innervating rat lumbar intervertebral discs...
  83. ncbi The hsp150 delta-carrier confers secretion competence to the rat nerve growth factor receptor ectodomain in Saccharomyces cerevisiae
    M Simonen
    Institute of Biotechnology, University of Helsinki, Finland
    Yeast 12:457-66. 1996
    ..The hsp150 delta-carrier may have potential in the production of mammalian proteins, which require elaborate folding and disulphide formation in the ER...
  84. ncbi Selective changes in hippocampal neuropeptide Y neurons following removal of the cholinergic septal inputs
    T A Milner
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York 10021, USA
    J Comp Neurol 386:46-59. 1997
    ..The changes in NPY immunoreactivity seem to occur in the portion of interneurons that probably does not contain either SOM or GABA immunoreactivity...
  85. ncbi Clinical-scale selection of anti-CD3/CD28-activated T cells after transduction with a retroviral vector expressing herpes simplex virus thymidine kinase and truncated nerve growth factor receptor
    Paul J Orchard
    Program in Blood and Marrow Transplantation, Department of Pediatrics, Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    Hum Gene Ther 13:979-88. 2002
    ..3% vs. 23.5%). We conclude that a strategy based on activation of human T cells with anti-CD3/CD28 beads can result in sufficient transduction, expansion, and purification based on NGFR expression for clinical trials...
  86. doi Spiral ganglion outgrowth and hearing development in p75-deficient mice
    Dominik Brors
    Department of Otolaryngology, Head and Neck Surgery, Ruhr University Bochum, Bochum, Germany
    Audiol Neurootol 13:388-95. 2008
    ..P75(NTR) has a remarkable influence on spiral ganglion neurite growth behavior. However, p75(NTR) does not seem to be essential for the development of basic hearing function in the first 3 postnatal weeks...
  87. doi p75(NTR) induces apoptosis in medulloblastoma cells
    Jan Küchler
    Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
    Int J Cancer 128:1804-12. 2011
    ..In summary, our data link activated Hedgehog signaling in DMB with p75(NTR) expression and characterize p75(NTR) as a biologically relevant inductor of apoptosis in MB...
  88. ncbi Sustained gene expression in retrovirally transduced, engrafting human hematopoietic stem cells and their lympho-myeloid progeny
    L Cheng
    SyStemix, Inc, Palo Alto, CA, USA
    Blood 92:83-92. 1998
    ..These findings suggest potential utility of the MSCV retroviral vector in the development of effective therapies involving gene-modified HSC...
  89. ncbi p75(NGFR) and cholinergic neurons in the developing forebrain: a re-examination
    N L Ward
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, N S, Canada
    Brain Res Dev Brain Res 118:79-91. 1999
    ..The discrepant results of the previous study are most likely due to a less rigorous application of criteria for data acquisition, including anatomical boundaries that define the nucleus...
  90. ncbi Interaction of lyssaviruses with the low-affinity nerve-growth factor receptor p75NTR
    C Tuffereau
    Laboratoire de Genetique des Virus, Bat 14B, Centre National de la Recherche Scientifique, 91198, Gif sur Yvette Cedex, France
    J Gen Virol 82:2861-7. 2001
    The low-affinity nerve-growth factor receptor p75NTR interacts in vitro with the rabies virus (RV) glycoprotein and serves as a receptor for RV. The Lyssavirus genus comprises seven genotypes (GTs) of rabies and rabies-related viruses...
  91. doi Anti-L-NGFR and -CD34 monoclonal antibodies identify multipotent mesenchymal stem cells in human adipose tissue
    Nadia Quirici
    Fondazione Matarelli, Department of Medical Pharmacology, Universita degli Studi di Milano, Milan, Italy
    Stem Cells Dev 19:915-25. 2010
    ..We have previously reported that the low-affinity nerve growth factor receptor (L-NGFR or CD271) defines a subset of cells with high proliferative, clonogenic, and multipotential differentiation ability in ..
  92. ncbi Localization of bromodeoxyuridine-incorporating, p63- and p75(NGFR)- expressing cells in the human gingival epithelium
    Setsuko Hatakeyama
    Department of Oral Pathology, School of Dentistry, Iwate Medical University, Morioka, Japan
    J Oral Sci 49:287-91. 2007
    ..examined for the presence of bromodeoxyuridine (BrdU)-incorporating, p63- and low affinity nerve growth factor receptor (p75(NGFR))-expressing cells...
  93. ncbi Reduction of nerve growth factor receptor immunoreactivity in ischaemic gerbil hippocampal CA1 neurons after treatment with L-threo-3,4-dihydroxyphenylserine (DOPS)
    T H Lee
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Neurol Res 16:201-4. 1994
    ..These data suggest that the protective role of DOPS on the ischaemic hippocampal CA1 cells may act through the NGF and its receptor system...
  94. pmc Low-affinity nerve-growth factor receptor (P75NTR) can serve as a receptor for rabies virus
    C Tuffereau
    Laboratoire de Genetique des Virus, CNRS, 91198 Gif sur Yvette, France
    EMBO J 17:7250-9. 1998
    ..We identified the murine low-affinity nerve-growth factor receptor, p75NTR. BSR cells stably expressing p75NTR were able to bind Gs and G-expressing lepidopteran cells...
  95. ncbi Gene structure and chromosomal assignment of mouse GITR, a member of the tumor necrosis factor/nerve growth factor receptor family
    G Nocentini
    Department of Clinical and Experimental Medicine, Perugia University Medical School, Italy
    DNA Cell Biol 19:205-17. 2000
    ..These results further indicate that GITR shares several features with OX40, 4-1BB, and CD27, suggesting the existence of a new subfamily of the TNFR family, as also confirmed by the similarity of their cytoplasmic domains...
  96. ncbi High nerve growth factor receptor (p75NTR) expression is a favourable prognostic factor in paediatric B cell precursor-acute lymphoblastic leukaemia
    Anja Troeger
    Clinic for Paediatric Haematology, Oncology and Immunology, Heinrich Heine University, Duesseldorf, Germany
    Br J Haematol 139:450-7. 2007
    Nerve growth factor (NGF) plays a pivotal role in cellular survival/death decisions with the low affinity receptor p75NTR predominately transmitting anti-proliferative signals...
  97. ncbi [Comparison between CD271 and CD133 used for immunomagnetic positive sorting enriching in mesenchymal stem cells from bone marrow]
    Wei Lin
    Peking University Institute of Hematology, Peking University People Hospital, Beijing 100044, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:333-8. 2008
    ..better method to isolate and enrich mesenchymal stem cells (MSCs)from bone marrow between CD271 (low affinity nerve growth factor receptor, LNGFR) and CD133 used for immunomagnetic positive selections through comparison of ..
  98. doi Low-affinity nerve growth factor receptor (P75 NGFR) as a marker of perineural invasion in malignant melanomas
    Maren M Chan
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    J Cutan Pathol 37:336-43. 2010
    ..We hypothesize that P75 NGFR, a nerve growth factor receptor, may be implicated in the pathogenesis of PNI in these tumors...
  99. ncbi Low-affinity nerve growth factor receptor is associated with motoneuron axonal pathways
    H Tanaka
    Department of Pharmacology, Gunma University, School of Medicine, Maebashi, Japan
    Neurosci Res 27:21-7. 1997
    ..Furthermore, at the subcellular level, M7412 labeling was co-localized with bound NGF. The M7412 antigen is thus chicken LNGFR, whose role in motoneuron outgrowth pathways is discussed...
  100. pmc Role of p75NTR in female rat urinary bladder with cyclophosphamide-induced cystitis
    Mary Beth Klinger
    Dept of Neurology, Univ of Vermont College of Medicine, D415A Given Research Bldg, Burlington, VT 05405, USA
    Am J Physiol Renal Physiol 295:F1778-89. 2008
    ..The overall activity of the urinary bladder reflects the balance of NGF-p75(NTR) and NGF-TrkA signaling...
  101. ncbi Effects of aging and axotomy on the expression of neurotrophin receptors in primary sensory neurons
    E Bergman
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    J Comp Neurol 410:368-86. 1999
    ..We have here examined the expression of neurotrophin receptor (p75NTR, trkA, trkB, and trkC) mRNA and protein in intact and axotomized primary sensory neurons of young adult (3 months) ..

Research Grants63

  1. Evaristus A Nwulia; Fiscal Year: 2015
    ....
  2. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2011
    ..S. civilians could be adversely affected by highly toxic chemicals released intentionally in terrorist attacks or unintentionally in industrial accidents or natural disasters. ..
  3. Factors Responsible for Cardiac Preservation Conferred by Adult Marrow Stem Cells
    Jeffrey L Spees; Fiscal Year: 2012
    ..conditioned by mixed MSCs or by standardized MSCs isolated by magnetic sorting for the p75 low affinity nerve growth factor receptor (p75LNGFR;p75MSCs) can support the growth and survival of adult cardiac stem/progenitor cells ..
  4. NERVE GROWTH FACTOR RECEPTOR MEDIATED TRANSPORT TOPICS
    John Schweitzer; Fiscal Year: 1991
    ..the lateral ventricle of the rat, both nerve growth factor (NGF) and a monoclonal antibody directed against the NGF receptor, IgG 192, are transported bilaterally to numerous neurons with topographic and morphologic characteristics of ..
  5. NERVE GROWTH FACTOR
    Mark Bothwell; Fiscal Year: 1991
    ..Sepecific aims are to produce polyclonal antibodies reactive to various regions of the NGF receptor to be used for immunocytochemical localization of receptor...
  6. NERVE GROWTH FACTOR RECEPTOR--A MOLECULAR ANALYSIS
    Barbara Hempstead; Fiscal Year: 1990
    ..Thus, the NGF-NGF receptor interaction serves as an important model system to use in investigating the normal mechanisms which regulate ..
  7. Huaxi Xu; Fiscal Year: 2016
    ..secretase complex components, nicastrin, APH-1 and PEN-2, and the two nerve growth factor receptors, TrkA and p75NTR, are also regulated by APP...
  8. Estrogenic-cholinergic interactions in memory modulation
    KARYN FRICK; Fiscal Year: 2004
    ..abstract_text> ..
  9. Sphingosine 1 Phosphate Receptor and Neurite Retraction
    Rachelle Toman; Fiscal Year: 2003
    ..Such agents might be useful as potential treatments for developmental disorders as well as the neurodegeneration in Alzheimer's disease, Pick's disease, ischemia, and traumatic injury. ..
  10. PATHOLOGY IN ALZHEIMER'S DISEASE
    Gerald Higgins; Fiscal Year: 1990
    ..Subsequent studies will be undertaken in human brain, to determine if a similar relationship exists between nerve growth factor receptor regulation and hippocampal pathology and gene expression in AD...
  11. DETECTOR & GENERATOR FOR CRYSTALLOGRAPHY CORE FACILITY
    Joseph Wedekind; Fiscal Year: 2001
    ..Such work has practical applications to human diseases in terms of diagnosis, prevention, and therapeutic development...
  12. p75 Expression for Assessing Neurotoxicity
    William Valentine; Fiscal Year: 2003
    ..The low affinity nerve growth factor receptor (p75) has been most extensively characterized and has exhibited the greatest increases and ..
  13. A New Tool for Targeted Antisense Knockdown in Brain
    Robert Gibbs; Fiscal Year: 2006
    ..nucleic acid) to selectively knock down expression of the nerve growth factor receptor TrkA within targeted p75NTR-expressing cells in the basal forebrain...
  14. IMAGING MULTIGENE TRANSDUCTIONS
    Juri Gelovani; Fiscal Year: 2002
    ..and three genes of therapeutic interest [double mutant dihydrofolate reductase (DHFR), mutant low affinity nerve growth factor receptor (NTP), and granulocyte-macrophage colony stimulating factor (GM-CSF)] that have different sites ..
  15. NEUROTROPHINS, HORMONES AND POSTPAROUS INCONTINENCE
    Peter Smith; Fiscal Year: 2004
    ..determine the extent to which estrogen and pregnancy influence expression of the neurotrophin receptors trkA and p75NTR, which mediate the sympathetic nerve response to NGF and NT3...
  16. HUMAN NEUROBLASTOMA ANTIGENS
    Robert Seeger; Fiscal Year: 2000
    ..these receptors; 2) by altering signal transduction downstream from these receptors; and/or 3) by creating a NGF/p75NTR autocrine, anti-apoptotic loop. Specific Aims...
  17. MECHANISMS OF NEUROTROPHIN RECEPTOR CROSSTALK
    RICK DOBROWSKY; Fiscal Year: 2002
    ..their interaction with two distinct receptors, the Trk tyrosine kinase family of receptors and the low affinity p75NTR receptor...
  18. PLASMALOPSYCHOSINE AS NEUROTROPHIC FACTOR
    Senitiroh Hakomori; Fiscal Year: 2003
    ..of PLPS with neurotrophin receptors and "glycosignaling domain" (GSD) which lead to activation of TrkA, p75NTR and other GSD-associated signal transducers; (5) anti-apoptotic activity of PLPS for normal, primary cultured ..
  19. Receptor Tyrosine Kinase Sorting and Transactivation in Endosomes
    MARK LINDSAY GRIMES; Fiscal Year: 2010
    ..from one another into specific signaling endosomes? The two receptors for nerve growth factor (NGF), TrkA and p75NTR, are rapidly sorted upon ligand binding to distinct endosomes...
  20. MECHANISMS OF CELLULAR RESPONSES TO NERVE GROWTH FACTOR
    Steven Green; Fiscal Year: 1990
    ..The first project involves studies of the NGF receptor (NGFR) itself, focussing on regulation of its affinity, internalization and intracellular transport...
  21. P75NTR Small Molecule Ligands for Down Syndrome Therapy
    Frank M Longo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This application titled "P75NTR Small Molecule Ligands for Down Syndrome Therapy" is in response to NINDS Exploratory/Developmental Projects in Translational Reseach (R21;program announcement: PAR-11-..
  22. Grant D Nicol; Fiscal Year: 2015
    ..can rapidly increase the ability of sensory neurons to fire action potentials (APs) via p75 neurotrophin receptor (p75NTR) activation of the sphingolipid signaling cascade...
  23. NGF Receptor Regulates Prostate Growth
    Daniel Djakiew; Fiscal Year: 2009
    ..One such receptor is the p75NTR, a cell surface protein that binds the neurotrophins (e.g. nerve growth factor)...
  24. Molecular mechanisms of perineural invasion in pancreatic cancer
    Haiyong Han; Fiscal Year: 2010
    ..The specific aims of this project are: 1) to determine the specific role of NGF and its receptors (TrkA and p75NTR) in the invasion of pancreatic cancer cells into peripheral nerves using in vitro and ex vivo perineural invasion ..
  25. The Role of Local BDNF Synthesis in Spine Morphogenesis
    LAUREN LYNN OREFICE; Fiscal Year: 2012
    ..abstract_text> ..
  26. Azza B el-Remessy; Fiscal Year: 2016
    ..homeostasis in diabetes can lead to accumulation of its precursor proNGF and upregulation of the death receptor p75NTR, leading to vascular injury...
  27. Italo Mocchetti; Fiscal Year: 2016
    ..the proneurotrophin brain-derived neurotrophic factor (proBDNF) and are mediated by the p75 neurotrophin receptor (p75NTR), a member of the tumor necrosis factor family...
  28. Neurotrophic factors and excitability
    Grant Nicol; Fiscal Year: 2007
    ..A fundamental understanding of such events could lead to better designed compounds and therapies to facilitate the treatment of chronic inflammatory conditions. [unreadable] [unreadable]..
  29. ROLE OF ONCOGENES IN NERVE GROWTH FACTOR'S ACTION
    RALPH AARONS; Fiscal Year: 1993
    ..studies demonstrate that a clonal cell line (PCNA) expressing high levels of the low-affinity form of the NGF receptor can be transfected successfully with a mamalian expression vector carrying a specific oncogene and that these ..
  30. STRUCTURE AND FUNCTION OF NERVE GROWTH FACTOR
    RALPH BRADSHAW; Fiscal Year: 2000
    ..factor (3 receptor (hPDGFbetaR), chimeric receptors with the transmembrane and intracellular domains of TrkA (NGF receptor), TrkE (a putative NGF receptor), EGFR, p75 (the low molecular weight NGFR) and c-Src will be constructed and ..
  31. Piyush M Patel; Fiscal Year: 2016
    ..In the absence of tPA, proBDNF is uncleaved and preferentially signals through p75NTR receptors, resulting in reduced synaptogenesis, withdrawal of dendritic spines and neuronal apoptosis [20]...
  32. STRUCTURE/FUNCTION OF NERVE GROWTH FACTOR/NEUROTROPHINS
    KENNETH NEET; Fiscal Year: 2009
    ..NGF), interact with two types of receptors, the Trk tyrosine kinase receptor and the common neurotrophin receptor p75NTR, to support neuronal development in responsive peripheral neurons (sensory, sympathetic) and central neurons (..
  33. Neurotrophin mimetic therapeutics for HIV-associated neural dysfunction
    Rick B Meeker; Fiscal Year: 2013
    ..These compounds are targeted to specific epitopes of the p75 neurotrophin receptor (p75NTR) or receptor tyrosine kinase B (TrkB), thereby allowing a greater degree of control over signaling than seen with ..
  34. Stephen M Massa; Fiscal Year: 2016
    ..LM11A) that potently promote neuronal survival through selective interactions with the neurotrophin receptor p75NTR, inhibit proNGF-induced death, and promote neural progenitor cell proliferation...
  35. Y S Prakash; Fiscal Year: 2016
    ..low affinity p75NTR) vis-[unreadable]vis ASM contractility...
  36. p75NTR-Ceramide Signaling in Alzheimer?s Disease
    Luigi Puglielli; Fiscal Year: 2012
    ..PRELIMINARY DATA: In the Preliminary Studies section, we show that p75NTR and ceramide are required for the age-associated activation of A( generation...
  37. Aging and Alzheimer's Disease Potential Link with IGF1-R
    Luigi Puglielli; Fiscal Year: 2012
    ..have recently shown that normal aging of the brain is characterized by a progressive switch from the TrkA to the p75NTR receptor system that leads to activation of the second messenger ceramide and increased production of amyloid 2-..
  38. Multipotent mesenchymal stem cell-like cells in pancreatic tumorigenesis
    NADEZDA ALEKSANDROVNA ISACHENKO; Fiscal Year: 2012
    ..While there are many signaling pathways and factors that would be worthwhile and important to assess, I decided to focus on PDGFR2 and CD271/p75 as a potential regulators of MPMSC differentiation into pericytes.
  39. Frank M Longo; Fiscal Year: 2014
    ..The current proposal will test whether a small molecule, non-peptide ligand for the p75 neurotrophic receptor (p75NTR) will be an effective treatment for Huntington's disease (HD)...
  40. Gabriele Bergers; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): We recently discovered a p75NTR+/CD133+ population of multipotent mesenchymal stem-cell-like cells (MPMSC) in pancreatic neuroendocrine tumors that exhibit high self-renewal capacity and differentiate ..
  41. Neurotrophins in the Injured Brain
    Wilma J Friedman; Fiscal Year: 2013
    ..It has recently been shown that neurotrophin precursors, proneurotrophins, selectively bind and activate p75NTR, effectively eliciting apoptosis, while the mature (cleaved) neurotrophins preferentially activate Trk signaling, ..
  42. AJAY THOMAS; Fiscal Year: 2014
    ..and mBDNF appear to play contrary roles in the nervous system since they primarily activate different receptors, p75NTR and TrkB, respectively...
  43. Katerina Akassoglou; Fiscal Year: 2015
    ..We have shown that the neurotrophin receptor p75NTR regulates repair processes by inhibiting fibrin degradation and regulating cell differentiation...
  44. Gerald J Taborsky; Fiscal Year: 2014
    ..In our third Specific Aim we will prevent the loss of islet sympathetic nerves by knocking out p75NTR, again preserving the glucagon response to sympathetic nerve activation...
  45. NEUROTROPHIN ROLE IN OXIDATIVE HOMEOSTASIS AFTER STROKE
    JOSE PEREZ POLO; Fiscal Year: 1999
    ..These studies will provide insights into the mechanism of stroke pathophysiology and suggest new therapeutic approaches. ..
  46. Mechanisms of Sympathetic Axon Pruning
    Peter G Smith; Fiscal Year: 2010
    ..The first aim evaluates the hypothesis that p75NTR activation is responsible for inducing sympathetic axon degeneration under physiological conditions...
  47. Yogesh Dwivedi; Fiscal Year: 2016
    ..In addition, we have found that p75NTR, a low affinity BDNF receptor is upregulated in the brain of these subjects...
  48. STEM CELL FACTOR ACTION IN NEURAL CREST DEVELOPMENT
    Maya Sieber Blum; Fiscal Year: 2003
    ..survival factor for neural crest stem cells, (2) SCF is involved in the expression of the neurotrophin receptors, p75NTR and TrkC, and (3) SCF promotes differentiation of the stem cell into small diameter sensory neuroblasts...
  49. The Role of Presenilins in HIV Associated Dementia
    Suman Jayadev; Fiscal Year: 2010
    ..expression in HAD brain of two Y-secretase substrates implicated in the microglia inflammatory response, ErbB4 and p75NTR. We will determine if the known y-secretase components assemble in microglia using co-immunoprecipitation and ..
  50. Novel Prionic Mechanism Underlying Alzheimer?s Disease
    Dale E Bredesen; Fiscal Year: 2012
    ..This finding also implies that netrin-1 is an "endogenous anti-prion" and a molecule that enhances this process, p75NTR, is "prionogenic"...
  51. How Does Exercise Counteract Stress-Induced Tumor Growth
    Rosemarie Schmandt; Fiscal Year: 2010
    ..The receptors for these two molecules, p75NTR and TrkB respectively, are also expressed by ovarian tumors...
  52. Steven H Green; Fiscal Year: 2015
    ..Finally, in Aim 4, we use p75NTR knockout mice to test the hypothesis that the neurotrophin receptor p75NTR promotes reinnervation after ..
  53. Carol M Troy; Fiscal Year: 2016
    ..ProNGF is a high affinity ligand for p75NTR, and we have shown that signaling through p75NTR activates caspase-9...
  54. Alexander D Boiko; Fiscal Year: 2015
    ..In this project we propose that melanoma is driven by subpopulation of CD271 positive tumor initiating cells...
  55. Isolation and Characterization of Tumor Stem Cells from Melanoma Patients
    Alexander D Boiko; Fiscal Year: 2012
    ..In this project we propose that melanoma is driven by subpopulation of CD271 positive tumor initiating cells...
  56. MOLECULAR DETERMINANTS OF BRAIN-METASTATIC MELANOMA
    Dario Marchetti; Fiscal Year: 2010
    ..and using our BMM cellular models, we have accumulated evidence demonstrating that the neurotrophin receptor p75NTR and neurotrophin-regulated heparanase (HPSE) are critical determinants of brain metastasis...
  57. Soy phytoestrogen neuroprotection in cerebral ischemia
    DEREK SCHREIHOFER; Fiscal Year: 2007
    ..of the neuroprotective genes BDNF, NGF, Bcl-2, BCl-xL, and TrkB and reduce expression of the pro-apoptotic p75 NTR in brain regions damaged by middle cerebral artery occlusion...
  58. The Role of Cholesterol in Regulating NGF Activity
    JOSEPH BARTOE; Fiscal Year: 2004
    ..These data suggest the hypothesis that defects in cholesterol uptake and/or metabolism give rise to defects in NGF receptor signaling and trafficking, which in turn, contributes to neurodegeneration...
  59. Exploring the role of Phosphodiesterase 4A in axonal regeneration
    Benjamin Sachs; Fiscal Year: 2007
    ..Our preliminary data indicate that: 1. Expression of the p75 neurotrophin receptor (p75NTR), a receptor implicated in the inhibition of neurite outgrowth and nerve regeneration, leads to decreased cAMP ..
  60. CHOLINERGIC DENERVATION AND REINNERVATION IN AGING
    Sonsoles De Lacalle; Fiscal Year: 1999
    ..My long term goal is to apply this model to dissect the cellular and molecular mechanisms that may be involved in cholinergic fiber sprouting (or lack thereof in old age. ..
  61. HUMAN ANTITAT INTRABODY GENE THERAPY AGAINST SHIV
    Wayne Marasco; Fiscal Year: 2001
    ..In addition, the results from these studies will substantially advance our understanding of how to apply and improve this promising technology for the treatment of HIV-1 infection and AIDS. ..
  62. p75NTR proteolysis in Alzheimer's Disease
    Natalie Landman; Fiscal Year: 2006
    ..We have recently reported that the p75 neurotrophin receptor (p75NTR) undergoes PS-dependent APP-like proteolysis (1)...