p63

Summary

Gene Symbol: p63
Description: tumor protein p63
Alias: AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L, tumor protein 63, amplified in squamous cell carcinoma, chronic ulcerative stomatitis protein, keratinocyte transcription factor KET, transformation-related protein 63, tumor protein p53-competing protein
Species: human

Top Publications

  1. ncbi p63 expression profiles in human normal and tumor tissues
    Charles J Di Como
    Division of Molecular Pathology, Department of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Cancer Res 8:494-501. 2002
  2. pmc Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains
    Pamela Ghioni
    Dipartimento di Genetica e Biologia dei Microrganismi, Milan, Italy
    Mol Cell Biol 22:8659-68. 2002
  3. ncbi Identification of vitamin D receptor as a target of p63
    R Kommagani
    Department of Biochemistry and Molecular Biology, Dayton, OH 45435, USA
    Oncogene 25:3745-51. 2006
  4. ncbi Utility of WT-1, p63, MOC31, mesothelin, and cytokeratin (K903 and CK5/6) immunostains in differentiating adenocarcinoma, squamous cell carcinoma, and malignant mesothelioma in effusions
    Robert T Pu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Diagn Cytopathol 36:20-5. 2008
  5. ncbi p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
    A Yang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 2:305-16. 1998
  6. ncbi Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome
    J Celli
    Department of Human Genetics 417, University Hospital Nijmegen, The Netherlands
    Cell 99:143-53. 1999
  7. pmc A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer
    Lambertus A Kiemeney
    Department of Epidemiology, Biostatistics and Health Technology Assessment, Nijmegen, The Netherlands
    Nat Genet 42:415-9. 2010
  8. pmc Diverse p63 and p73 isoforms regulate Δ133p53 expression through modulation of the internal TP53 promoter activity
    V Marcel
    Centre for Oncology and Molecular Medicine, Inserm European Associated Laboratory, Ninewells Hospital and Medical School, Dundee, DD1 9SY, Scotland, UK
    Cell Death Differ 19:816-26. 2012
  9. doi A study of ΔNp63 expression in lung non-small cell carcinomas
    Daisuke Nonaka
    Department of Histopathology, the Christie NHS Foundation Trust, Wilmslow Road, Manchester, UK
    Am J Surg Pathol 36:895-9. 2012
  10. pmc RNPC1, an RNA-binding protein and a target of the p53 family, regulates p63 expression through mRNA stability
    Jin Zhang
    Comparative Cancer Center, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 107:9614-9. 2010

Research Grants

  1. ACTIVATION OF NF-KB IN GLIAL CELLS AND CNS OF EAE
    Kalipada Pahan; Fiscal Year: 2009
  2. Luis Alfonso Martinez; Fiscal Year: 2016
  3. Lionel B Ivashkiv; Fiscal Year: 2016
  4. ANDRIY MORGUN; Fiscal Year: 2015
  5. MOLECULAR REGULATION OF INTERLEUKIN 12 GENE EXPRESSION
    Xiaojing Ma; Fiscal Year: 2003
  6. Pairing of EBI-3 and IL12 p35 To Yield A Novel Regulatory T cell Cytokine
    LAUREN COLLISON; Fiscal Year: 2009
  7. Mechanism of p63-Dependent Tumor Suppression
    Xinbin Chen; Fiscal Year: 2012
  8. P63/IGFBP3/BCL2 Control of Corneal Epithelial Homeostasis
    Danielle M Robertson; Fiscal Year: 2011
  9. Xinbin Chen; Fiscal Year: 2015
  10. Guy Howard; Fiscal Year: 2015

Detail Information

Publications331 found, 100 shown here

  1. ncbi p63 expression profiles in human normal and tumor tissues
    Charles J Di Como
    Division of Molecular Pathology, Department of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Cancer Res 8:494-501. 2002
    The p63 gene, located on chromosome 3q27-28, is a member of the p53 gene family. The product encoded by the p63 gene has been reported to be essential for normal development.
  2. pmc Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains
    Pamela Ghioni
    Dipartimento di Genetica e Biologia dei Microrganismi, Milan, Italy
    Mol Cell Biol 22:8659-68. 2002
    b>p63 is a transcription factor structurally related to the p53 tumor suppressor. The C-terminal region differs from p53's in that it contains a sterile alpha motif (SAM) domain and is subject to multiple alternative splicings...
  3. ncbi Identification of vitamin D receptor as a target of p63
    R Kommagani
    Department of Biochemistry and Molecular Biology, Dayton, OH 45435, USA
    Oncogene 25:3745-51. 2006
    b>p63, a p53 homolog has been shown to play a role in development and cancer. p63 is essential for both commitment of ectoderm to stratified epithelia and for the proliferative potential of epithelial stem cells...
  4. ncbi Utility of WT-1, p63, MOC31, mesothelin, and cytokeratin (K903 and CK5/6) immunostains in differentiating adenocarcinoma, squamous cell carcinoma, and malignant mesothelioma in effusions
    Robert T Pu
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Diagn Cytopathol 36:20-5. 2008
    ..This study evaluates the utility of WT-1, p63, MOC31, mesothelin, and cytokeratin (K903 and CK5/6) immunostains in effusions when ADC and SCC of the lung are in ..
  5. ncbi p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
    A Yang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 2:305-16. 1998
    We describe the cloning of p63, a gene at chromosome 3q27-29 that bears strong homology to the tumor suppressor p53 and to the related gene, p73...
  6. ncbi Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome
    J Celli
    Department of Human Genetics 417, University Hospital Nijmegen, The Netherlands
    Cell 99:143-53. 1999
    ..families to a region of chromosome 3q27 previously implicated in the EEC-like disorder, limb mammary syndrome (LMS)...
  7. pmc A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer
    Lambertus A Kiemeney
    Department of Epidemiology, Biostatistics and Health Technology Assessment, Nijmegen, The Netherlands
    Nat Genet 42:415-9. 2010
    ..The frequency of rs798766[T] is higher in Ta tumors that carry an activating mutation in FGFR3 than in Ta tumors with wild-type FGFR3. Our results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC...
  8. pmc Diverse p63 and p73 isoforms regulate Δ133p53 expression through modulation of the internal TP53 promoter activity
    V Marcel
    Centre for Oncology and Molecular Medicine, Inserm European Associated Laboratory, Ninewells Hospital and Medical School, Dundee, DD1 9SY, Scotland, UK
    Cell Death Differ 19:816-26. 2012
    ..Here, we report that, in addition to p53, at least four p63/p73 isoforms regulate Δ133p53 expression at transcriptional level: p63β, ΔNp63α, ΔNp63β and ΔNp73γ...
  9. doi A study of ΔNp63 expression in lung non-small cell carcinomas
    Daisuke Nonaka
    Department of Histopathology, the Christie NHS Foundation Trust, Wilmslow Road, Manchester, UK
    Am J Surg Pathol 36:895-9. 2012
    ..of 150 lung adenocarcinomas and 50 squamous cell carcinomas were immunostained by antibodies for p63 (4A4), ΔNp63 (p40), and TTF-1 (8G7G3/1)...
  10. pmc RNPC1, an RNA-binding protein and a target of the p53 family, regulates p63 expression through mRNA stability
    Jin Zhang
    Comparative Cancer Center, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 107:9614-9. 2010
    b>P63, a p53 family tumor suppressor, is involved in many cellular processes, including growth suppression and differentiation. Thus, p63 activity needs to be tightly controlled...
  11. pmc Increased numbers of P63-positive/CD117-positive cells in advanced adenoid cystic carcinoma give a poorer prognosis
    Quan Zhou
    Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Dongjiaominxiang No, 1 Dongcheng District, Beijing, China
    Diagn Pathol 7:119. 2012
    ..The other was to analyze the relationship between the expression of CD117 and the histological grade and the prognosis...
  12. pmc p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53
    G Melino
    Medical Research Council, Toxicology Unit, Hodgkin Building, Leicester University, Leicester, UK
    Cell Death Differ 18:1487-99. 2011
    ..This effect seems mediated at least partially by its ability to physically interact with p63, thus affecting a cell invasion pathway, and accordingly, p63 is deregulated in human cancers...
  13. pmc Identification and functional characterization of two new transcriptional variants of the human p63 gene
    Marina Mangiulli
    Dipartimento di Biochimica e Biologia Molecolare E Quagliariello, Universita degli Studi di Bari, Via Orabona 4, 70126 Bari, Italy
    Nucleic Acids Res 37:6092-104. 2009
    b>p63 belongs to a family of transcription factors, which, while demonstrating striking conservation of functional domains, regulate distinct biological functions...
  14. pmc Comprehensive mutational analysis and mRNA isoform quantification of TP63 in normal and neoplastic human prostate cells
    J Kellogg Parsons
    Division of Urology, University of California, San Diego Medical Center, San Diego, California, USA
    Prostate 69:559-69. 2009
    ..b>p63 protein is found in the nuclei of basal cells of the normal prostate, yet it is absent in the vast majority of ..
  15. doi Dominant negative (DeltaN) p63alpha induces drug resistance in hepatocellular carcinoma by interference with apoptosis signaling pathways
    Heiko M Mundt
    Department of Internal Medicine IV, University Hospital, Heidelberg, Germany
    Biochem Biophys Res Commun 396:335-41. 2010
    b>p63 belongs to the family of p53-related transcription factors expressing a variety of isoforms. The Trp63 gene has two promoters that drive the expression of two major p63 isoform subfamilies...
  16. doi Mutant p53 subverts p63 control over KLF4 expression in keratinocytes
    N Cordani
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano Via Celoria 26, Milano, Italy
    Oncogene 30:922-32. 2011
    Genetic experiments established that p63 is crucial for the development and maintenance of pluri-stratified epithelia and KLF4 for the barrier function of the skin. KLF4 is one of the factors that reprogram differentiated cells to iPS...
  17. pmc Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma
    Matthew R Ramsey
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 71:4373-9. 2011
    ..A unifying feature of SCC is high-level expression of the p53-related protein p63 (TP63) in 80% of cases...
  18. pmc p63 identifies keratinocyte stem cells
    G Pellegrini
    Laboratory of Tissue Engineering IDI, Istituto Dermopatico dell Immacolata, 00040 Rome, Italy
    Proc Natl Acad Sci U S A 98:3156-61. 2001
    ..Here we show that the p63 transcription factor, a p53 homologue essential for regenerative proliferation in epithelial development, ..
  19. ncbi Delta Np63 alpha expression is regulated by the phosphoinositide 3-kinase pathway
    Christopher E Barbieri
    Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 278:51408-14. 2003
    b>p63 is a homologue of p53 that functions to maintain progenitor cell populations in stratified epithelia. Delta Np63 alpha is overexpressed in epithelial cancers and has been shown to have oncogenic properties...
  20. ncbi Immunohistochemical expression of p63, p53 and MIB-1 in urinary bladder carcinoma. A tissue microarray study of 158 cases
    Eva Comperat
    Service Central d Anatomie et Cytologie Pathologiques et d Urologie, hôpital La Pitié Salpêtrière, 83, Bd de l Hopital, 75013 Paris, France
    Virchows Arch 448:319-24. 2006
    b>P63 is a member of the p53 family, which plays a role in the differentiation of urothelium and is supposed to play a role in urothelial carcinogenesis...
  21. doi Giant cell tumor of bone express p63
    Brendan C Dickson
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Mod Pathol 21:369-75. 2008
    b>p63 contributes to skeletal development and tumor formation; however, little is known regarding its activity in the context of bone and soft tissue neoplasms...
  22. ncbi Diagnostic and prognostic impact of p63 immunoreactivity in renal malignancies
    Burcin Tuna
    Department of Pathology, Dokuz Eylul University Medical Faculty, Inciralti, Izmir, Turkey
    Anal Quant Cytol Histol 31:118-22. 2009
    To determine the ability of p63 reactivity to confirm the diagnosis of urothelial carcinomas (UCs) that present clinically as kidney masses and to determine the association of p63 expression with clinicopathologic features in UCs.
  23. doi Molecular basis of EEC (ectrodactyly, ectodermal dysplasia, clefting) syndrome: five new mutations in the DNA-binding domain of the TP63 gene and genotype-phenotype correlation
    S E Clements
    Genetic Skin Disease Group, St John s Institute of Dermatology, King s College London Guy s Campus, London, UK
    Br J Dermatol 162:201-7. 2010
    ..We highlight the significant intra- and interfamilial phenotypic variability in affected individuals and outline the emerging paradigm for genotype-phenotype correlation in this inherited ectodermal dysplasia syndrome...
  24. doi Expression of p63 is the sole independent marker of aggressiveness in localised (stage I-II) Merkel cell carcinomas
    Sofia Asioli
    Department of Biomedical Sciences and Human Oncology, University of Torino, Torino, Italy
    Mod Pathol 24:1451-61. 2011
    ..The same cases were studied for p63 expression by immunohistochemistry, by reverse-transcription PCR (RT-PCR) and TP63 gene status by FISH and for ..
  25. pmc p63 regulates human keratinocyte proliferation via MYC-regulated gene network and differentiation commitment through cell adhesion-related gene network
    Ning Wu
    Commissariat a l Energie Atomique, Biologie à Grande Echelle, F 38054 Grenoble, France
    J Biol Chem 287:5627-38. 2012
    Although p63 and MYC are important in the control of epidermal homeostasis, the underlying molecular mechanisms governing keratinocyte proliferation or differentiation downstream of these two genes are not completely understood...
  26. pmc A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism
    Zach Serber
    Graduate Group in Biophysics, University of California San Francisco, San Francisco, California 94143, USA
    Mol Cell Biol 22:8601-11. 2002
    ..The p53 homologue p63, for example, is a tetrameric transcription factor implicated in epithelial development and expressed as at least ..
  27. ncbi Endogenous p63 acts as a survival factor for tumour cells of SCCHN origin
    Niklas Thurfjell
    Department of Medical Biosciences Pathology, Umea University, SE 901 85 Umea, Sweden
    Int J Mol Med 16:1065-70. 2005
    The human p63 gene encodes a series of proteins that differ in their N- and/or C-terminal sequences and have widely differing properties in promoting or repressing p53-related functions such as growth arrest and apoptosis...
  28. doi IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias
    Barbara Marinari
    Department of Dermatology, University of Rome Tor Vergata, Rome, Italy
    J Invest Dermatol 129:60-9. 2009
    The transcription factor p63 plays a pivotal role in the development and differentiation of the epidermis and epithelial appendages...
  29. pmc Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo
    Annie Yang
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 5:e11572. 2010
    The p53 homologs, p63 and p73, share approximately 85% amino acid identity in their DNA-binding domains, but they have distinct biological functions.
  30. pmc TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria
    Olav Gressner
    Department of Internal Medicine IV, Hepatology and Gastroenterology, University Hospital, Heidelberg, Germany
    EMBO J 24:2458-71. 2005
    TP63, an important epithelial developmental gene, has significant homology to p53. Unlike p53, the expression of p63 is regulated by two different promoters resulting in proteins with opposite functions: the full-length transcriptionally ..
  31. ncbi DeltaNp63 expression is associated with poor survival in ovarian cancer
    S Marchini
    Laboratory of Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Ann Oncol 19:501-7. 2008
    b>P63 belongs to the 'p53 family' whose role in cancer progression has been recently revisited in light of the plethora of splicing variants that are generated...
  32. pmc The p53 homologue DeltaNp63alpha interacts with the nuclear factor-kappaB pathway to modulate epithelial cell growth
    Kathryn E King
    Division of Monoclonal Antibodies, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Cancer Res 68:5122-31. 2008
    ..This is the first report indicating that high levels of DeltaNp63alpha interact with activated c-Rel in keratinocytes and SCC, thereby promoting uncontrolled proliferation, a key alteration in the pathogenesis of cancers...
  33. pmc HuR is necessary for mammary epithelial cell proliferation and polarity at least in part via ΔNp63
    Wensheng Yan
    Comparative Oncology Laboratory, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e45336. 2012
    ..Consistent with this, we identified two U-rich elements in the 3'-untranslated region of p63 mRNA, to which HuR specifically binds...
  34. pmc Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63
    Yong Sam Jung
    Comparative Oncology Laboratory, University of California, Davis, Davis, California 95616, USA
    J Invest Dermatol 133:1178-87. 2013
    b>p63, a homolog of the tumor-suppressor p53, is essential for the development of the epidermis and limbs. p63 is highly expressed in the epithelial cell layer and acts as a molecular switch that initiates epithelial stratification...
  35. ncbi Expression of p63 in cutaneous metastases
    Jean Kanitakis
    Laboratory of Dermatopathology, Ed Herriot Hospital, Lyon, France
    Am J Clin Pathol 128:753-8. 2007
    b>p63 is an oncogene belonging to the p53 gene family...
  36. ncbi Split-hand/split-foot malformation with paternal mutation in the p63 gene
    I Witters
    Department of Obstetrics and Gynecology, University of Leuven, Leuven, Belgium
    Prenat Diagn 21:1119-22. 2001
    ..Mutation analysis of the p63 gene on chromosome 3q27 showed a missense mutation 577A-->G (predicting amino acid substitution K193E) in the ..
  37. pmc The E3 ubiquitin ligase Itch controls the protein stability of p63
    Mario Rossi
    Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, United Kingdom
    Proc Natl Acad Sci U S A 103:12753-8. 2006
    b>p63, a member of the p53 family of transcription factors, plays an important role in epithelial development, regulating both cell cycle and apoptosis...
  38. doi Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation
    Sibel Aylin Ugur
    Department of Molecular Biology and Genetics, Boaziçi University, Istanbul 34342, Turkey
    Hum Mol Genet 17:2644-53. 2008
    ..Four of the loci were excluded, while in TP63 [tumor protein p63 (SHFM4)], the only known gene responsible for SHFM, we detected in most affected subjects a rare insertion variant (..
  39. ncbi Recognition of p63 by the E3 ligase ITCH: Effect of an ectodermal dysplasia mutant
    A Bellomaria
    Dipartimento di Scienze e Tecnologie Chimiche, University of Rome Tor Vergata, Italy
    Cell Cycle 9:3730-9. 2010
    The E3 ubiquitin ligase Itch mediates the degradation of the p63 protein. Itch contains four WW domains which are pivotal for the substrate recognition process...
  40. ncbi The EEC syndrome and SHFM: report of two cases and mutation analysis of p63 gene
    Hacer Ergin
    Department of Pediatrics, Pamukkale University Faculty of Medicine, Denizli, Turkey
    Turk J Pediatr 52:529-33. 2010
    The p63 gene is a transcription factor and a member of the p53 family. Heterozygote mutation of the p63 gene is suggested in a number of human syndromes including limb development and/or ectodermal dysplasia...
  41. ncbi The Role of p63 and p73 in tumor formation and progression: coming of age toward clinical usefulness. Commentary re: F. Koga et al., Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of th
    Ute M Moll
    Department of Pathology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Clin Cancer Res 9:5437-41. 2003
  42. pmc YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets
    R Ehsanian
    Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 1419, USA
    Oncogene 29:6160-71. 2010
    ..AKT and/or ΔNp63 are potential targets for enhancing YAP-mediated apoptosis and chemosensitivity in HNSCCs...
  43. ncbi Yes-associated protein 1 regulates the stability of DeltaNp63alpha
    Aditi Chatterjee
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cell Cycle 9:162-7. 2010
    ..Thus, our results strongly suggest that Yap1 plays a role in the regulation of endogenous DeltaNp63alpha levels and is likely to contribute to the regulation of DeltaNp63alpha, in physiological conditions...
  44. doi Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6
    Sanjay Mukhopadhyay
    Department of Pathology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Am J Surg Pathol 35:15-25. 2011
    ..biopsies and resections were stained with CK7, TTF-1, napsin A (novel aspartic proteinase of the pepsin family), p63, CK5/6, and 34βE12...
  45. ncbi Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in human cancer cell lines using intronic primers
    K Hagiwara
    Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 59:4165-9. 1999
    ..identification of p73, a second homologue of the human p53 tumor suppressor gene has been reported and named p63/p73L/p51/p40/CUSP/KET...
  46. pmc Split-hand/split-foot malformation is caused by mutations in the p63 gene on 3q27
    P Ianakiev
    Department of Pediatrics, University of Connecticut Health Center, Farmington 06030, USA
    Am J Hum Genet 67:59-66. 2000
    ..Results of gene-targeting studies have demonstrated that p63, a homologue of the cell-cycle regulator TP53, plays a critically important role in regulation of the formation and ..
  47. pmc Regulation of p53 family member isoform DeltaNp63alpha by the nuclear factor-kappaB targeting kinase IkappaB kinase beta
    Aditi Chatterjee
    Division of Head and Neck Cancer Research, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 70:1419-29. 2010
    The p53 family gene p63 plays an instrumental role in cellular stress responses including responses to DNA damage...
  48. pmc DNA-binding and transactivation activities are essential for TAp63 protein degradation
    Haoqiang Ying
    Department of Biochemistry, Boston University School of Medicine, K423, 715 Albany St, Boston, Massachusetts 02118, USA
    Mol Cell Biol 25:6154-64. 2005
    The p53-related p63 gene encodes six isoforms with differing N and C termini. TAp63 isoforms possess a transactivation domain at the N terminus and are able to transactivate a set of genes, including some targets downstream of p53...
  49. ncbi Cloning and chromosomal mapping of the human p53-related KET gene to chromosome 3q27 and its murine homolog Ket to mouse chromosome 16
    M Augustin
    Fraunhofer Institute of Toxicology and Aerosol Research, Center for Medical Biotechnology and Department of Cell Biology, Nikolai Fuchs Str 1, D 30625 Hannover, Germany
    Mamm Genome 9:899-902. 1998
    b>KET is a member of the newly discovered family of proteins that is related to the tumor suppressor p53. Here we describe the molecular cloning of a human cDNA of 4846 bp encoding a protein of 680 amino acids...
  50. ncbi Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63
    Pascal H G Duijf
    Department of Human Genetics 417, University Medical Centre Nijmegen, Box 9101, 6500 HB Nijmegen, The Netherlands
    Hum Mol Genet 11:799-804. 2002
    The transcriptional co-activator p63 is of crucial importance for correct development of the limbs, ectodermal appendages (skin, nails, teeth, hair, glands), lip and palate...
  51. ncbi p53 and Delta Np63 alpha differentially bind and regulate target genes involved in cell cycle arrest, DNA repair and apoptosis
    K L Schavolt
    Department of Biochemistry, Center for Molecular Toxicology, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA
    Oncogene 26:6125-32. 2007
    ....
  52. ncbi Physical interaction between Wilms tumor 1 and p73 proteins modulates their functions
    V Scharnhorst
    Laboratory of Molecular Carcinogenesis and Centre for Biomedical Genetics, Leiden University Medical Center, P O Box 9503, 2300 RA Leiden, The Netherlands
    J Biol Chem 275:10202-11. 2000
    ..This, taken together with our finding that WT1 also interacts with p63/KET, another p53 homologue, suggests that association between WT1 and the members of the p53 family of proteins may be ..
  53. pmc AIS is an oncogene amplified in squamous cell carcinoma
    K Hibi
    Department of Otolaryngology Head and Neck Surgery, Division of Head and Neck Cancer Research, Johns Hopkins University School of Medicine, 818 Ross Research Building, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Proc Natl Acad Sci U S A 97:5462-7. 2000
    ..We named this locus AIS for amplified in squamous cell carcinoma.) Furthermore, amplification of the AIS locus was accompanied by RNA and protein overexpression of ..
  54. ncbi Mutations in the p53 homolog p63: allele-specific developmental syndromes in humans
    Hans van Bokhoven
    Dept of Human Genetics, University Medical Center Nijmegen, The Netherlands
    Trends Mol Med 8:133-9. 2002
    b>p63 is the most recently discovered but most ancient member of the p53 family. In marked contrast to p53, p63 is highly expressed in embryonic ectoderm and in the basal, regenerative layers of many epithelial tissues in the adult...
  55. pmc The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations
    Matthew D Westfall
    Department of Biochemistry, Center in Molecular Toxicology, The Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Mol Cell Biol 23:2264-76. 2003
    b>p63 is a recently identified homolog of p53 that is found in the basal layer of several stratified epithelial tissues such as the epidermis, oral mucosa, prostate, and urogenital tract...
  56. ncbi DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development
    Guojun Wu
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Cancer Res 63:2351-7. 2003
    The p63 gene shows remarkable structural similarity to the p53 and p73 genes. Because of two promoters, the p63 gene generates two types of protein isoforms, TAp63 and DeltaNp63...
  57. ncbi TAp63gamma can substitute for p53 in inducing expression of the maspin tumor suppressor
    Katja Spiesbach
    Department of Internal Medicine II, University of Leipzig, Leipzig, Germany
    Int J Cancer 114:555-62. 2005
    ..Maspin gene expression can be upregulated by the tumor suppressor p53. We tested 7 p53-related proteins of the p63 and p73 families for their ability to induce maspin expression...
  58. ncbi Connecting p63 to cellular proliferation: the example of the adenosine deaminase target gene
    Elisabetta Sbisà
    Istituto Tecnologie Biomediche CNR Sede di Bari di Bioinformatica e Genomica, Bari, Italy
    Cell Cycle 5:205-12. 2006
    An unresolved issue regards the role of p73 and p63, the two homologs of the p53 oncosuppressor gene, in normal cells and in tumor development...
  59. ncbi Dual regulation of the DeltaNp63 transcriptional activity by DeltaNp63 in human nasopharyngeal carcinoma cell
    Wing Keung Chu
    Department of Physiology, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
    Biochem Biophys Res Commun 342:1356-60. 2006
    b>p63 splicing variants lacking NH(2)-terminal transactivating domain, known as DeltaNp63, are thought to antagonize p53 and p63 functions and are suggested to play roles in keratinocyte differentiation...
  60. pmc Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation
    Bach Cuc Nguyen
    Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA, and Department of Biochemistry, University of Lausanne, Switzerland
    Genes Dev 20:1028-42. 2006
    Notch signaling promotes commitment of keratinocytes to differentiation and suppresses tumorigenesis. p63, a p53 family member, has been implicated in establishment of the keratinocyte cell fate and/or maintenance of epithelial self-..
  61. ncbi p63 regulates an adhesion programme and cell survival in epithelial cells
    Danielle K Carroll
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Nat Cell Biol 8:551-61. 2006
    b>p63 is critical for epithelial development yet little is known about the transcriptional programmes it regulates...
  62. ncbi Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells
    Annie Yang
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 24:593-602. 2006
    Using tiled microarrays covering the entire human genome, we identify approximately 5800 target sites for p63, a p53 homolog essential for stratified epithelial development...
  63. pmc Reciprocal regulation of p63 by C/EBP delta in human keratinocytes
    Serena Borrelli
    Dipartimento di Scienze Biomolecolari e Biotecnologie, U, di Milano, Via Celoria 26, 20133 Milano, Italy
    BMC Mol Biol 8:85. 2007
    Genetic experiments have clarified that p63 is a key transcription factor governing the establishment and maintenance of multilayered epithelia. Key to our understanding of p63 strategy is the identification of target genes...
  64. doi Correlation of p63 immunoreactivity with tumor grade in meningiomas
    Elisabeth J Rushing
    Department of Neuropathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Int J Surg Pathol 16:38-42. 2008
    ..The present study was undertaken to assess the correlation between p63 expression and histological grade of meningiomas...
  65. ncbi [Expression of GLUT-1, p63 and DNA-Pkcs in serous ovarian tumors and their significance]
    Shu Li Shao
    Department of Gynecology, Tumor Hospital of Shanxi Province, Taiyuan 030013, China
    Zhonghua Zhong Liu Za Zhi 29:697-700. 2007
    To investigate the expression of GLUT1, p63 and DNA-Pkcs in serous ovarian tumors and their significance.
  66. doi miR-203 represses 'stemness' by repressing DeltaNp63
    A M Lena
    Biochemistry Laboratory IDI IRCCS and University of Rome Tor Vergata, Department of Experimental Medicine and Biochemical Sciences, Rome, Italy
    Cell Death Differ 15:1187-95. 2008
    ..The epidermis develops depending on the transcription factor p63, a member of the p53 family of transcription factors...
  67. ncbi Phospho-DeltaNp63alpha/NF-Y protein complex transcriptionally regulates DDIT3 expression in squamous cell carcinoma cells upon cisplatin exposure
    Yiping Huang
    Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cell Cycle 9:328-38. 2010
    ....
  68. ncbi Cloning and functional analysis of human p51, which structurally and functionally resembles p53
    M Osada
    Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Nat Med 4:839-43. 1998
    ..9 kDa. In contrast with the ubiquitous expression of p53, expression of p51 mRNA was found in a limited number of tissues, including skeletal muscle, placenta, mammary gland, prostate, ..
  69. ncbi The p53 family member genes are involved in the Notch signal pathway
    Yasushi Sasaki
    Department of Molecular Biology, Cancer Research Institute, Sapporo Medical University School of Medicine, S 1, W 17, Chuo Ku, Sapporo, 060 8556 Japan
    J Biol Chem 277:719-24. 2002
    ..p63/p51 and p73 were recently identified as members of the p53 gene family...
  70. ncbi Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders
    J N Glickman
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Pathol 32:1157-65. 2001
    b>p63 is a p53-related DNA-binding protein that helps regulate differentiation and proliferation in epithelial progenitor cells. Its expression has never been evaluated in the human gastrointestinal tract...
  71. ncbi p63
    Natalie A Little
    Department of Molecular and Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Centre, P O Box 9503, 2300 RA Leiden, The Netherlands
    Int J Biochem Cell Biol 34:6-9. 2002
    The p63 gene, a member of the p53 gene family, is expressed into at least six protein isoforms which are divided into two groups, those containing the transcription activation domain (TA isoforms) and those that do not (Delta N isoforms)...
  72. ncbi p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
    Elsa R Flores
    Massachusetts Institute of Technology, Department of Biology and Center for Cancer Research, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nature 416:560-4. 2002
    ..Although the p53 family members p63 and p73 are structurally related to p53, they have not been directly linked to tumour suppression, although they ..
  73. pmc Loss of p63 expression is associated with tumor progression in bladder cancer
    Marshall J Urist
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Am J Pathol 161:1199-206. 2002
    b>p63, a member of the p53 gene family, encodes multiple proteins that may either transactivate p53 responsive genes (TAp63) or act as a dominant-negative factor toward p53 and p73 (Delta Np63)...
  74. ncbi p63 in laryngeal squamous cell carcinoma: evidence for a role of TA-p63 down-regulation in tumorigenesis and lack of prognostic implications of p63 immunoreactivity
    Giancarlo Pruneri
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Lab Invest 82:1327-34. 2002
    b>p63 is a p53-related gene that encodes for multiple mRNA transcripts with (TA-p63) or without (DeltaN-p63) transactivating properties on p53-responsive genes...
  75. ncbi The relationship between p63 and p53 expression in normal and neoplastic breast tissue
    Alfredo Ribeiro-Silva
    Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo FMRP USP, Sao Paulo, Brazil
    Arch Pathol Lab Med 127:336-40. 2003
    b>p63 is a recently described p53 homologue. Despite structural homology, they have different activities.
  76. pmc ASPP1 and ASPP2: common activators of p53 family members
    Daniele Bergamaschi
    Ludwig Institute for Cancer Research, Imperial College School of Medicine, St Mary s Campus, London W2 1PG, United Kingdom
    Mol Cell Biol 24:1341-50. 2004
    ..We show here that ASPP1 and ASPP2 also induce apoptosis independently of p53. By binding to p63 and p73 in vitro and in vivo, ASPP1 and ASPP2 stimulate the transactivation function of p63 and p73 on the ..
  77. ncbi RACK1 and stratifin target DeltaNp63alpha for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage
    Alexey Fomenkov
    Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell Cycle 3:1285-95. 2004
    ..Our data suggest that modification and down regulation of DeltaNp63alpha is one of the major determinants of the cellular response to DNA damage in human head and neck cancers...
  78. pmc Differential recognition of response elements determines target gene specificity for p53 and p63
    Motonobu Osada
    Department of Otolaryngology, Division of Head and Neck Surgery, Johns Hopkins University School of Medicine, 818 Ross Research Building, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Mol Cell Biol 25:6077-89. 2005
    b>p63 is a member of the p53 tumor suppressor gene family, which regulates downstream target gene expression by binding to sequence-specific response elements similar to those of p53...
  79. ncbi The unique NH2-terminally deleted (DeltaN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DeltaN variant of p63
    E Scott Helton
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    J Biol Chem 281:2533-42. 2006
    b>p63, a member of the p53 family of transcription factors, is known to be involved in epithelial development. However, its role in tumorigenesis is unclear...
  80. ncbi p63 and epithelial biology
    Christopher E Barbieri
    Department of Biochemistry, Center in Molecular Toxicology, 652 Preston Research Building, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Exp Cell Res 312:695-706. 2006
    The transcription factor p63 is a homologue of the tumor suppressor p53...
  81. ncbi p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis
    James W Rocco
    Massachusetts General Hospital Center for Cancer Research and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Cell 9:45-56. 2006
    ..Inhibition of endogenous p63 expression by RNAi induces apoptosis selectively in HNSCC cells that overexpress deltaNp63alpha...
  82. pmc An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionarily conserved enhancer
    Dario Antonini
    Telethon Institute of Genetics and Medicine, Via Pietro Castellino 111, 80131 Naples, Italy
    Mol Cell Biol 26:3308-18. 2006
    b>p63, a p53 family member, is essential for the development of various stratified epithelia and is one of the earliest markers of many ectodermal structures, including the epidermis, oral mucosa, apical ectodermal ridge, and mammary gland...
  83. pmc A mutation of the p63 gene in non-syndromic cleft lip
    P Leoyklang
    J Med Genet 43:e28. 2006
    Mutations in the p63 gene (TP63) underlie several monogenic malformation syndromes manifesting cleft lip with or without cleft palate (CL/P). We investigated whether p63 mutations also result in non-syndromic CL/P...
  84. ncbi Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma
    Maurice Phillip DeYoung
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    Cancer Res 66:9362-8. 2006
    b>p63 is essential for normal epithelial development and is overexpressed in the vast majority of squamous cell carcinomas (SCC)...
  85. ncbi p63 overexpression induces the expression of Sonic Hedgehog
    Tina M Caserta
    Department of Biochemistry and Molecular Biology, Wright State University, Dayton, OH 45435, USA
    Mol Cancer Res 4:759-68. 2006
    b>p63 and p73 are members of the p53 protein family and have been shown to play an important role in cell death, development, and tumorigenesis...
  86. ncbi p63 protects the female germ line during meiotic arrest
    Eun Kyung Suh
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 444:624-8. 2006
    ..Here we show that the p53 homologue p63 (refs 5, 6), and specifically the TAp63 isoform, is constitutively expressed in female germ cells during meiotic ..
  87. ncbi Properties of the six isoforms of p63: p53-like regulation in response to genotoxic stress and cross talk with DeltaNp73
    A Petitjean
    INSERM UMR590, Unité d Oncogenèse et de Progression Tumorale, Centre Leon Berard, 28 rue Laennec, F69008 Lyon, France
    Carcinogenesis 29:273-81. 2008
    ..role of these isoforms and to better understand their functional overlap with p53, we ectopically expressed each p63 isoform in the p53-null hepatocellular carcinoma cell line Hep3B...
  88. pmc ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage
    Yiping Huang
    Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cell Cycle 7:2846-55. 2008
    ..Our results implicate specific kinases, and target phosphorylation sites in the degradation of Delta Np63 alpha following DNA damage...
  89. pmc Sequence variant on 8q24 confers susceptibility to urinary bladder cancer
    Lambertus A Kiemeney
    Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Nat Genet 40:1307-12. 2008
    ..A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 x 10(-7))...
  90. pmc Homeodomain protein Dlx3 induces phosphorylation-dependent p63 degradation
    Antonella Di Costanzo
    Department of Structural and Molecular Biology, University of Naples, Naples, Italy
    Cell Cycle 8:1185-95. 2009
    The epidermis is a stratified epithelium which develops depending on the transcription factor p63, a member of the p53 family of transcription factors...
  91. doi A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis
    Maddalena Adorno
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua School of Medicine, viale Colombo 3, 35100 Padua, Italy
    Cell 137:87-98. 2009
    ..we show that TGFbeta-dependent cell migration, invasion and metastasis are empowered by mutant-p53 and opposed by p63. Mechanistically, TGFbeta acts in concert with oncogenic Ras and mutant-p53 to induce the assembly of a mutant-p53/..
  92. pmc Structural evolution of p53, p63, and p73: implication for heterotetramer formation
    Andreas C Joerger
    Centre for Protein Engineering, Medical Research Council, Hills Road, Cambridge CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 106:17705-10. 2009
    Oligomerization of members of the p53 family of transcription factors (p53, p63, and p73) is essential for their distinct functions in cell-cycle control and development...
  93. pmc TAp63 regulates VLA-4 expression and chronic lymphocytic leukemia cell migration to the bone marrow in a CD74-dependent manner
    Inbal Binsky
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Immunol 184:4761-9. 2010
    ..These results could form the basis of novel therapeutic strategies aimed at blocking homing of CLL cells in their return to the BM and attenuating their survival...
  94. pmc A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias
    Francesca Moretti
    Department of Dermatology, University of Rome Tor Vergata, Rome, Italy
    J Clin Invest 120:1570-7. 2010
    ..Mutations in the p63 and interferon regulatory factor 6 (IRF6) genes have been found in human patients with these syndromes, consistent ..
  95. doi DeltaNp63alpha repression of the Notch1 gene supports the proliferative capacity of normal human keratinocytes and cervical cancer cells
    Takashi Yugawa
    Virology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Cancer Res 70:4034-44. 2010
    The p53 family member p63 is a master regulator of epithelial development...
  96. doi MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation
    Francesco Galli
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy
    J Cell Sci 123:2423-33. 2010
    Tight control of p63 protein levels must be achieved under differentiation or apoptotic conditions. Here, we describe a new regulatory pathway for the DeltaNp63alpha protein...
  97. doi Skn-1a/Oct-11 and ΔNp63α exert antagonizing effects on human keratin expression
    Anna Maria Lena
    Biochemistry IDI IRCCS Laboratory and Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    Biochem Biophys Res Commun 401:568-73. 2010
    ..demonstrate a direct interaction between ΔNp63 and Skn-1a, suggesting that the antagonistic effects of Skn-1a and p63 on keratin promoter transactivation is probably through competition for overlapping binding sites on target gene ..
  98. ncbi p63 (TP73L) a key player in embryonic urogenital development with significant dysregulation in human bladder exstrophy tissue
    Bonnie J Ching
    Section of Genetics, Department of Pediatrics, University of California Davis, Sacramento, CA 95817, USA
    Int J Mol Med 26:861-7. 2010
    ..Several lines of evidence implicate genetic factors in the formation of BEEC. Among them a murine p63+/+ knockout model showed the full picture of classic exstrophy of the bladder and other urogenital defects within ..
  99. pmc DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramer
    Gregor B Deutsch
    Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Frankfurt, Germany
    Cell 144:566-76. 2011
    ..Furthermore, we show that a helix in the oligomerization domain of p63 is crucial for tetramer stabilization and competes with the transactivation domain for the same binding site...
  100. pmc Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression
    Orit Karni-Schmidt
    Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
    Am J Pathol 178:1350-60. 2011
    ..The lack of p63 isoform-specific antibodies has limited the analysis of the biological significance of p63...
  101. doi The DeltaNp63 proteins are key allies of BRCA1 in the prevention of basal-like breast cancer
    Niamh E Buckley
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, United Kingdom
    Cancer Res 71:1933-44. 2011
    ..b>p63 family proteins that are structurally related to the p53 suppressor protein are known to function in stem cell ..

Research Grants77

  1. ACTIVATION OF NF-KB IN GLIAL CELLS AND CNS OF EAE
    Kalipada Pahan; Fiscal Year: 2009
    ..We have discovered a new group of inducers of NF-kappaB activation [interleukin-12 (IL-12) p40 homodimer (p40-2) and monomer (p40)] in glial cells. It was known that p40-2 and p40 were biologically inactive...
  2. Luis Alfonso Martinez; Fiscal Year: 2016
    ..the first involves the physical inactivation of other tumor suppressor proteins such as its family members, p63 and p73, and the other is dependent on its ability to regulate gene expression...
  3. Lionel B Ivashkiv; Fiscal Year: 2016
    ..important for host defense against intracellular pathogens and Th1 responses: Il12a (encoding IL-12 p35), Il12b (p40) and Nos2 (iNOS). Expression of these genes is regulated by IRF1, IRF8 and the NF-?B family member c-Rel...
  4. ANDRIY MORGUN; Fiscal Year: 2015
    ..Ustekinumab is a monoclonal antibody to the p40 subunit of interleukin-12/23...
  5. MOLECULAR REGULATION OF INTERLEUKIN 12 GENE EXPRESSION
    Xiaojing Ma; Fiscal Year: 2003
    ..IL-12 is a heterodimer consisted to two subunits, p40 and p35 that are encoded on different human chromosomes...
  6. Pairing of EBI-3 and IL12 p35 To Yield A Novel Regulatory T cell Cytokine
    LAUREN COLLISON; Fiscal Year: 2009
    Epstein barr virus induced gene 3 (EBI-3) is a soluble protein that shares structural similarities to the IL12 p40 chain...
  7. Mechanism of p63-Dependent Tumor Suppression
    Xinbin Chen; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): P63 is a member of the p53 family. When the upstream promoter is used for p63 expression, three major TAp63 isoforms, TAp63a, TAp63[unreadable], and TAp63?, are produced...
  8. P63/IGFBP3/BCL2 Control of Corneal Epithelial Homeostasis
    Danielle M Robertson; Fiscal Year: 2011
    ....
  9. Xinbin Chen; Fiscal Year: 2015
    ..tumor burdens and metastasis rates, which are compounded in mice harboring heterozygous alleles of p53 and/or p63. However, p73 is not a classic tumor suppressor since mutant mice are also prone to developmental defects, chronic ..
  10. Guy Howard; Fiscal Year: 2015
    ..Data shows that p63, a member of the p53 family of transcription factors, plays a major role in the cooperative actions of HGF and 1,..
  11. Role of PGE2 in CNS and peripheral autoimmune disorders
    Doina Ganea; Fiscal Year: 2010
    ..of the relevant signaling molecules and transcription factors involved in the PGE2 regulation of p19, p40, and p35 gene transcription...
  12. REGULATION AND FUNCTION OF KERATINS IN THE EPIDERMIS
    DENNIS ROOP; Fiscal Year: 2010
    ..We have recently demonstrated that the transcription factor p63 is the molecular switch for initiation of the epidermal stratification program...
  13. Takeshi Kurita; Fiscal Year: 2014
    ..demonstrated that developmental exposure to DES induces cervical/vaginal adenosis by disrupting expression of p63 transcription factor, which is essential for development of squamous epithelia...
  14. Rose Anne Romano; Fiscal Year: 2015
    ..sequencing data emerging from the Cancer Genome Atlas Project, strongly suggest that the transcription factor p63, specifically the most prevalent Np63 isoforms, function as an oncogene in the early stages of SCC development...
  15. Satrajit Sinha; Fiscal Year: 2014
    ..This is epitomized by the striking phenotype of the p63 knockout mice, which lack a mature stratified epidermis and exhibit a block in development of multiple ectodermal ..
  16. Maranke I Koster; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The p63 gene encodes several transcription factors that are required for normal development and homeostasis of the skin and its appendages...
  17. Xue Zhong Yu; Fiscal Year: 2016
    ..Specifically, we hypothesize that targeting p40, IL-12R[unreadable]1 or their downstream signaling events will disrupt Th1/Th17 differentiation and thus control ..
  18. KEVIN MATTHEW CURTIS; Fiscal Year: 2015
    ..During murine development, the transcription factor p63 is required for skeletal formation, and our recent work demonstrated that p63 is integral for hepatocyte growth ..
  19. James E Schwob; Fiscal Year: 2016
    ..Recently, we have shown that the transcription factor p63 is key to HBC differentiation and regeneration...
  20. JOHN J NGAI; Fiscal Year: 2015
    ..In this application we propose to investigate the role of the transcription factor p63 - a member of the p53 family of tumor suppressors - in olfactory stem cell regulation...
  21. Inhibition of Microflora-Induced Colitis by NF-kB
    Bruce H Horwitz; Fiscal Year: 2010
    ..part to a defect within hematopoietic cells of the innate immune system that leads to excessive production of IL-12 p40. In contrast, mice lacking the NF-(B subunit c-Rel, are resistant to colitis, and have reduced expression of IL-12 ..
  22. Novel Genetic Approach To Isolate Stem Cells Of The Oral Cavity
    Satrajit Sinha; Fiscal Year: 2012
    ..Recent studies have offered compelling evidence in support of the transcription factor p63, particularly the ?Np63 isoform, to be highly expressed in the stem cell compartment of the stratified squamous ..
  23. Olfactory Epithelial Stem Cell Regulation by the Transcription Factor p63
    Nikolai Schnittke; Fiscal Year: 2013
    ..The transcription factor p63, a member of the p53 family, is necessary for the embryonic appearance of HBCs and loss of p63 expression in the ..
  24. Functional analysis of the p53 tumor suppressor
    Moshe Oren; Fiscal Year: 2012
    ..genes in a manner leading to transcriptional silencing, explore the possibility that dominant negative forms of p63, a p53 family member, are responsible for the failure of p53 to function as an effective tumor suppressor in some ..
  25. Carol Prives; Fiscal Year: 2015
    ..an interdisciplinary and collaborative approach to understand the roles of mutant p53, p53 family member's p63 and p73 and new tumor suppressor genes in cancer...
  26. Cellular and molecular biology of lung surfactant
    Aron B Fisher; Fiscal Year: 2013
    ..This project provides novel information on P63 as a biologically-relevant SP-A receptor...
  27. JAN MATT VAN DE RIJN; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The current treatment of leiomyosarcoma (LMS), the most common form of sarcoma, involves ineffective systemic therapy that is based on a trial and error approach and on the assumption that tumors ..
  28. MOLECULAR PROGRESSION MODEL FOR HNSCC
    David Sidransky; Fiscal Year: 2012
    ..Specific tumor suppressor genes, including p14 and p16, and proto-oncogenes, including p63, have been identified as critical in oral cancer development...
  29. Fang Yan; Fiscal Year: 2016
    ..We have successfully purified and cloned two novel LGG-derived soluble proteins (p40 and p75) that prevent cytokine-induced apoptosis through activating Akt in intestinal epithelial cells...
  30. Novel Vaginal Microbicides Based On Stable AAV-Neutralizing Antibody Gene Transfe
    Wayne A Marasco; Fiscal Year: 2010
    ..comprising endocervical, ectocervical and vaginal epithelial cells with special focus on stable gene transfer into p63+CK17+epithelial stem cells which are capable of renewing stratified epithelium...
  31. Juan Luis Rendón; Fiscal Year: 2014
    ..our laboratory demonstrated decreased levels of Th17 effector cytokine IL-17 as well as decreased levels of the p40 subunit of IL-23 in Peyer's patches following alcohol intoxication and burn injury...
  32. IL-23 / Il-17 and Lung Host Defense
    Jay Kolls; Fiscal Year: 2009
    ..and the subsequent production of IL-23 (a novel heterodimeric cytokine composed of a unique p19 subunit and the p40 subunit of IL-12) by these cell populations which signal to T-cell to produce IL-17...
  33. Molecular immunologic role of cytokines in the development of malarial immunity
    JOHN MICHAEL ONGECHA; Fiscal Year: 2010
    ..IL-23 is a recently discovered pro-inflammatory cytokine that shares a common p40 subunit with IL-12...
  34. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD
    Kanneganti Murthy; Fiscal Year: 2013
    ..including eotaxin, G-CSF, GM-CSF, IFN-?, IL-1[unreadable], IL-2, IL4, IL-3, IL-5, IL-6, IL-7, IL-9, IL-10, IL-12 (p40), IL-12 (p70), IL-13, IL-15, IL-17, IP-10, KC, LIF, LIX, MCP-1, M-CSF, MIG, MIP-1[unreadable], MIP-1[unreadable], ..
  35. ANIL KUMAR JAISWAL; Fiscal Year: 2015
    ..that NQO1 and NQO2 stabilization of tumor suppressor p53 against 20S proteasome degradation and down regulation of p63 and MAPK pathway contributed to carcinogenesis...
  36. Yale Autoimmunity Center of Excellence
    Kevan C Herold; Fiscal Year: 2013
    ..The second trial is a Phase II trial of the anti-p40 mAb CNTO 1275 (Ustekinumab) for treatment of primary Sj"gren's syndrome...
  37. Control of Renal Glutaminase Expression during Acidosis
    Norman P Curthoys; Fiscal Year: 2012
    ..HuR and p40-AUF1 bind to the pHRE with high affinity and specificity...
  38. John C Schimenti; Fiscal Year: 2016
    ..We also found that both programmed and induced DSBs trigger CHK2-dependent phosphorylation of p63 (TRP63) in diplotene oocytes...
  39. Role of PUMA in EGFR targeted therapy in HNSCC
    Jian Yu; Fiscal Year: 2012
    ..Furthermore, EGFR TKIs induce PUMA through the effects on the p53 family members p63 and p73, but not p53 itself...
  40. G PROTEIN REGULATION OF THE NEUTROPHIL NADPH OXIDASE
    Celine DerMardirossian; Fiscal Year: 2010
    ..Preliminary data suggest that Src may act through unique "organizer" molecules that are structurally related to p40, p47, and Nox1, the known Nox regulatory proteins...
  41. Madhavi P Kadakia; Fiscal Year: 2016
    ..We have previously shown that VDR is positively regulated by the most abundant and physiologically relevant p63 isoform, [unreadable]Np63a...
  42. Miguel J Stadecker; Fiscal Year: 2016
    ..an expanded, clonally-restricted subpopulation is specific for the immunodominant epitope 234-246 of the major Sm-p40 schistosome egg antigen (Sm-p40234-246)...
  43. The role of p63 and p73 in cancer
    UTE MARTHA MOLL; Fiscal Year: 2012
    Title: the Role of p63 and p73 in Cancer PI: Ute M. Moll, M.D. Abstract p53 controls a powerful stress response and is a quintessential tumor suppressor...
  44. Inexpensive multiplexed ligation probe assay to genotype drug resistant M.tubberc
    HEATHER KOSHINSKY; Fiscal Year: 2012
    ..This will be accomplished in three specific objectives: (1) Design MLPA LHS and RHS probes. (2) Test probe sets. (3) Test on clinical MTB and sputum samples...
  45. Sergey V Nuzhdin; Fiscal Year: 2014
    ..common across taxa, social learning requires the integration of associative learning, memory and social behavior (LMS);and these vary considerably among individuals within a species...
  46. Jennifer A Pietenpol; Fiscal Year: 2014
    Although the pivotal role of p53 in tumor suppression remains unchallenged, the role of its family members, p63 and p73 in normal cell function and tumorigenesis is far from certain...
  47. Osteosarcoma Translational Research
    Qiping Zheng; Fiscal Year: 2013
    ..data from the principal investigator's group have shown that transgenic mice overexpressing Runx2 or P63 in hypertrophic chondrocytes result in delayed or accelerate chondrocyte maturation respectively...
  48. High throughput screens for modulators of inflammatory cytakine gene expression
    Stephen T Smale; Fiscal Year: 2010
    ..small molecules that differentially alter the expression of key cytokine genes, including the genes encoding IL-12 p40, IL-12 p35, IL-23 p19, and IL-10...
  49. Sheida Nabavi; Fiscal Year: 2014
    ..The recent discovery of the p63/p73 expression, p53 mutation and measurements of DNA repair status effects on the sensitivity to cisplatin in TNBC ..
  50. Severin O Gudima; Fiscal Year: 2014
    ..envelope protein coding sequence, and thus expressing all three HBV envelope proteins, large, middle and small (LMS vectors)...
  51. Elsa R Flores; Fiscal Year: 2015
    ..The functions of p63, a p53 family member, are beginning to be understood in contexts in which p53 function has been well established, ..
  52. CHEMICAL ARCHITECTURE OF RETINAL CIRCUITS
    Noga Vardi; Fiscal Year: 2012
    ..At P21-P40, the compound light response of ON bipolar cells will be recorded using electroretinograms, and a single rod ..
  53. Elda E Sanchez; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The Viper Resource Center (VRC), P40 competitive renewal, at Texas A&M University-Kingsville proposes to continue the aims of the initial grant application...
  54. Studies on the role of IL-23p19/IL-17 cascade in the pathogenesis of acute GVHD
    JOHN SECORD THOMPSON; Fiscal Year: 2012
    ..with bone marrow (BM) plus T- containing spleens (SCs) from mutant mice deficient in the p19 dimer of the IL-23 p19/p40 heterodimer develop aGVHD less frequently and less severely than BALB/c transplanted with normal wild type C57BL/6 ..
  55. p63-Dependent Checkpoints in Oocytes
    Frank D McKeon; Fiscal Year: 2010
    ..How DNA damage triggers the death of these arrested oocytes is poorly understood but we now know that p63, a homolog of the p53 tumor suppressor, is highly expressed in these oocytes and plays an essential role in their ..
  56. Mechanisms of Delta-N-p63-alpha transcriptional repression and its role in squamo
    CORRIE LYNN GALLANT-BEHM; Fiscal Year: 2013
    ....
  57. Leif W Ellisen; Fiscal Year: 2015
    ..Cell Carcinoma (HNSCC) and related cancers, by understanding the function and regulation of the p53 family members p63 and p73. The p53 family of proteins plays a key role in the pathogenesis of HNSCC...
  58. NICOLAS P SLUIS-CREMER; Fiscal Year: 2016
    ..HIV-1 RT is a heterodimer composed of a 66kDa subunit (p66), and a p66-derived 51kDa subunit (p51)...
  59. Sabina Signoretti; Fiscal Year: 2014
    ..The p63 gene is selectively expressed in basal cells of various epithelia and is required for epithelial development...
  60. Role of p53 homologs in DNA repair in human keratinocytes
    Dennis H Oh; Fiscal Year: 2013
    ..current award period has documented that keratinocytes require loss of both p53 and another member of the family-p63-before repair is compromised...
  61. A novel mouse prostate carcinogenesis model for dietary cancer prevention researc
    Chung S Yang; Fiscal Year: 2013
    ..NF-kB and CD45), and oxidative stress (8-OHdG and -H2AX), as well as the expression of GSTP1, E-cadherin, COX-2, p63, p27, Pten, Nkx3.1, p16, and Bcl-2 by immunohistochemistry (IHC)...
  62. Jason R Richardson; Fiscal Year: 2016
    ..chemistry has led to the identification of a candidate therapeutic that is a highly effective inhibitor of the P40 system...
  63. RONALD WAYNE DAVIS; Fiscal Year: 2014
    ..trait loci (QTL) will be identified by combining three innovative strategies: reciprocal hemizygosity scanning (RHS), bulk segregant analysis (BSA) and classical linkage mapping (CLM) using whole genome sequencing...
  64. P63 Network in Pathogenesis of Ectodermal Dysplasia
    Alexey Fomenkov; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): We hypothesize that p63 functions through physical and functional interaction with other cellular proteins contributing in regulation of cell proliferation, differentiation and ..
  65. Xinbin Chen; Fiscal Year: 2016
    ..e., p63 and p73), which would then enhance gain of function for these p53 mutants...
  66. CHARLOTTE LOUISE GROVE; Fiscal Year: 2014
    ..In larval zebrafish horizontal eye movements are produced by Hox3 dependent networks arising in rhombomeres (rhs) 5-6...
  67. Laimonis A Laimins; Fiscal Year: 2014
    ..Additional important activities identified for E6 include blocking of p300 acetylation of p53 and activation of p63 upon differentiation...
  68. Christian R Abee; Fiscal Year: 2016
    ..by applicant): This application requests renewal of the "Squirrel Monkey Breeding and Research Resource" (SMBRR), P40 RR01254 which has received continuous NCRR support since 1980...
  69. KEVIN BESEY; Fiscal Year: 2016
    ..would support the development of that infrastructure by developing and implementing a Learning Management System (LMS)...
  70. Carrie J Shawber; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Lymphatic malformations (LMs) are congenital lesions affecting 1:3500 children usually manifesting in early childhood, and are associated with significant morbidities, including vision loss, ..
  71. Cytoplasmic Reactivation of p53 Family Members
    Charles Walker; Fiscal Year: 2004
    ..leukemia in the soft-shell clam, Mya arenaria, in which clam homologs that we have identified for human p53 and p63/73 proteins are rendered non-functional by their sequestration in the cytoplasm of leukemic clam hemocytes...
  72. Novel Vaginal Microbicides Based On Stable AAV-Neutralizing Antibody Gene Transfe
    Wayne Marasco; Fiscal Year: 2009
    ..comprising endocervical, ectocervical and vaginal epithelial cells with special focus on stable gene transfer into p63+CK17+epithelial stem cells which are capable of renewing stratified epithelium...
  73. Oxytocin, Postnatal Experience & Adult Maternal Behavior
    Cort Pedersen; Fiscal Year: 2006
    ..In Preliminary Studies, rat dams subjected to brief and long daily maternal separations (BMS vs. LMS) during infancy exhibited, respectively, increased and decreased pup-grooming (PG), maternal aggression and ..