p50

Summary

Gene Symbol: p50
Description: nuclear factor kappa B subunit 1
Alias: CVID12, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50, nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, NF-kappabeta, nuclear factor NF-kappa-B p50 subunit, nuclear factor kappa-B DNA binding subunit, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Species: human

Top Publications

  1. ncbi The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
    Haihong Zhong
    Immunobiology Section and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Cell 9:625-36. 2002
  2. ncbi TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains
    Atsuhiro Kanayama
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell 15:535-48. 2004
  3. pmc Activation of NF-kappaB signaling by inhibitor of NF-kappaB kinase beta increases aggressiveness of ovarian cancer
    Lidia Hernandez
    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 1906, USA
    Cancer Res 70:4005-14. 2010
  4. doi Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, 1007 MC Amsterdam, The Netherlands
    Nat Immunol 10:203-13. 2009
  5. pmc The NF-kappaB family of transcription factors and its regulation
    Andrea Oeckinghaus
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cold Spring Harb Perspect Biol 1:a000034. 2009
  6. pmc TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein
    Deborah L Clarke
    Nottingham Respiratory Biomedical Research Unit, City Hospital, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 285:29101-10. 2010
  7. ncbi The NF-kappa B and I kappa B proteins: new discoveries and insights
    A S Baldwin
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599, USA
    Annu Rev Immunol 14:649-83. 1996
  8. pmc Pathobiological implications of the expression of EGFR, pAkt, NF-κB and MIC-1 in prostate cancer stem cells and their progenies
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e31919. 2012
  9. ncbi Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis
    Amir S Karban
    Johns Hopkins University School of Medicine, 1503 E Jefferson Street, Room B136, Baltimore, MD 21231, USA
    Hum Mol Genet 13:35-45. 2004
  10. doi Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-kappaB activity in hypoxic tumor cells
    G Y Jang
    Department of Biochemistry and Molecular Biology Aging and Apoptosis Research Center AARC, Seoul National University College of Medicine, Seoul 110 799, Korea
    Oncogene 29:356-67. 2010

Research Grants

  1. INDER MOHAN VERMA; Fiscal Year: 2014
  2. Hypothermia enhances inflammatory cytokine expression via NF-kappa B
    Karen D Fairchild; Fiscal Year: 2010
  3. Androgen Receptor-JunD Complex Inhibitors to Prevent Prostate Cancer Progression
    Hirak S Basu; Fiscal Year: 2012
  4. Effect of beta-glucan on sepsis
    COURTNI NEWSOME; Fiscal Year: 2009
  5. Cohort Study of Glucosamine and Chondroitin Supplement Use and Cancer Risk
    Emily White; Fiscal Year: 2012
  6. Sp1, kappa-B enhancers and transcriptions in neurons
    STEVEN BARGER; Fiscal Year: 2009
  7. Stuart B Goodman; Fiscal Year: 2016
  8. Gourisankar Ghosh; Fiscal Year: 2016
  9. Gourisankar Ghosh; Fiscal Year: 2015
  10. NF kappa B Activity in Skin Inflammation and Carcinogenesis
    Brian Poligone; Fiscal Year: 2013

Detail Information

Publications449 found, 100 shown here

  1. ncbi The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
    Haihong Zhong
    Immunobiology Section and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Cell 9:625-36. 2002
    Homodimers of the NF-kappa B p50 subunit are transcriptionally repressive in cells, whereas they can promote transcription in vitro, suggesting that their endogenous effects are mediated by association with other factors...
  2. ncbi TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains
    Atsuhiro Kanayama
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell 15:535-48. 2004
    ..These results indicate that polyubiquitin binding domains represent a new class of signaling domains that regulate protein kinase activity through a nonproteolytic mechanism...
  3. pmc Activation of NF-kappaB signaling by inhibitor of NF-kappaB kinase beta increases aggressiveness of ovarian cancer
    Lidia Hernandez
    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 1906, USA
    Cancer Res 70:4005-14. 2010
    ....
  4. doi Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, 1007 MC Amsterdam, The Netherlands
    Nat Immunol 10:203-13. 2009
    ..Thus, dectin-1 activates two independent signaling pathways, one through Syk and one through Raf-1, to induce immune responses...
  5. pmc The NF-kappaB family of transcription factors and its regulation
    Andrea Oeckinghaus
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cold Spring Harb Perspect Biol 1:a000034. 2009
    ..This has made the NF-kappaB pathway a paradigm for understanding general principles of signal transduction and gene regulation...
  6. pmc TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein
    Deborah L Clarke
    Nottingham Respiratory Biomedical Research Unit, City Hospital, University of Nottingham, Nottingham NG5 1PB, United Kingdom
    J Biol Chem 285:29101-10. 2010
    ....
  7. ncbi The NF-kappa B and I kappa B proteins: new discoveries and insights
    A S Baldwin
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599, USA
    Annu Rev Immunol 14:649-83. 1996
    ....
  8. pmc Pathobiological implications of the expression of EGFR, pAkt, NF-κB and MIC-1 in prostate cancer stem cells and their progenies
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e31919. 2012
    ....
  9. ncbi Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis
    Amir S Karban
    Johns Hopkins University School of Medicine, 1503 E Jefferson Street, Room B136, Baltimore, MD 21231, USA
    Hum Mol Genet 13:35-45. 2004
    ..The NFKB1 gene encodes the NF-kappaB p105/p50 isoforms. Genome-wide screens in IBD families show evidence for linkage on chromosome 4q where NFKB1 maps...
  10. doi Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-kappaB activity in hypoxic tumor cells
    G Y Jang
    Department of Biochemistry and Molecular Biology Aging and Apoptosis Research Center AARC, Seoul National University College of Medicine, Seoul 110 799, Korea
    Oncogene 29:356-67. 2010
    ..These findings suggest that the inhibition of TG2 may offer a novel strategy for anticancer therapy...
  11. pmc The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, 1550 NW 10 Avenue, Miami, FL 33136, USA
    J Virol 81:13735-42. 2007
    ..Collectively, our results reveal that Ubc13 is essential for Tax ubiquitination, its interaction with NEMO, and Tax-mediated NF-kappaB activation...
  12. pmc An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation
    Dimitrios Iliopoulos
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Cell 139:693-706. 2009
    ..Thus, inflammation activates a positive feedback loop that maintains the epigenetic transformed state for many generations in the absence of the inducing signal...
  13. ncbi IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis
    Yun Jin Jung
    Cell and Cancer Biology Branch, CCR, National Cancer Institute, 9610 Medical Center Dr, Suite 300, Rockville, Maryland 20850, USA
    FASEB J 17:2115-7. 2003
    ..Thus, HIF-1 is identified as a pivotal transcription factor linking the inflammatory and oncogenic pathways...
  14. pmc Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease
    Jian Guo Cui
    Department of Ophthalmology, Louisiana State University Health Science Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 285:38951-60. 2010
    ..The combinatorial use of NF-κB inhibitors with miRNA-146a or antisense miRNA-146a may have potential as a bi-pronged therapeutic strategy directed against IRAK-2-driven pathogenic signaling...
  15. pmc Phosphorylation and polyubiquitination of transforming growth factor beta-activated kinase 1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor
    Virginie Bottero
    Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
    J Virol 85:1980-93. 2011
    ..Finally, inhibition of TAK1 by celastrol inhibited vGPCR-induced NF-κB activation, indicating this natural compound could be used as a potential therapeutic drug against KSHV malignancies involving vGPCR...
  16. pmc The cytoplasmic domain of the HIV-1 glycoprotein gp41 induces NF-κB activation through TGF-β-activated kinase 1
    Thomas S Postler
    New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, MA 01772 9102, USA
    Cell Host Microbe 11:181-93. 2012
    ..These findings demonstrate an evolutionarily conserved role for gp41CD in activating NF-κB to promote infection...
  17. doi MiR-217 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation by down-regulation of SIRT1
    Hong Sheng Zhang
    College of Life Science and Bioengineering, Beijing University of Technology, Pingleyuan 100, District of Chaoyang, Beijing, China
    Biochim Biophys Acta 1823:1017-23. 2012
    ..Our results also suggest that strategies to augment SIRT1 protein expression by down-regulation of miR-217 may have therapeutic benefits to prevent HIV-1 replication...
  18. pmc Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells
    D Bhaumik
    Buck Institute for Age Research, Novato, CA 94945, USA
    Oncogene 27:5643-7. 2008
    ..These findings implicate miR-146a/b as a negative regulator of constitutive NF-kappaB activity in a breast cancer setting and suggest that modulating miR-146a/b levels has therapeutic potential to suppress breast cancer metastases...
  19. pmc miR-301a as an NF-κB activator in pancreatic cancer cells
    Zhongxin Lu
    Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY 40202, USA
    EMBO J 30:57-67. 2011
    ..Revealing this novel mechanism of NF-κB activation by an miRNA offers new avenues for therapeutic interventions against pancreatic cancer...
  20. ncbi New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases
    F Chen
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA lfd32cdc gov
    Clin Chem 45:7-17. 1999
    ..Therefore, development of modulatory strategies targeting this transcription factor may provide a novel therapeutic tool for the treatment or prevention of various diseases...
  21. ncbi Interleukin 1 activates STAT3/nuclear factor-kappaB cross-talk via a unique TRAF6- and p65-dependent mechanism
    Yasuhiro Yoshida
    New England Baptist Bone and Joint Institute, Beth Israel Deaconess Medical Center and the Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 279:1768-76. 2004
    ..The distinct p50 form of NF-kappaB is also shown to interact with STAT3...
  22. ncbi p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1
    Jan Bohuslav
    Gladstone Institute of Virology and Immunology and the Department of Medicine, University of California, San Francisco, California 94143 1234, USA
    J Biol Chem 279:26115-25. 2004
    ..These findings highlight a rather unusual pathway of NF-kappaB activation, which is utilized by the p53 tumor suppressor...
  23. pmc Activation of alternative NF-kappa B pathway by human herpes virus 8-encoded Fas-associated death domain-like IL-1 beta-converting enzyme inhibitory protein (vFLIP)
    Hittu Matta
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, 75390 8593, USA
    Proc Natl Acad Sci U S A 101:9399-404. 2004
    ..Therapeutic agents targeting the alternative NF-kappa B pathway may have a role in the treatment of KSHV-associated lymphomas...
  24. pmc Suppressor of cytokine signaling 3 inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages
    Lisa Nowoslawski Akhtar
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 185:2393-404. 2010
    ....
  25. pmc Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS)
    Mickael Ohanna
    Biologie et Pathologies des Mélanocytes de la Pigmentation Cutanée au Mélanome, Equipe labellisée Ligue Nationale Contre le Cancer, Nice, France
    Genes Dev 25:1245-61. 2011
    ..Collectively, identification of the PARP-1/NF-κB axis in secretome formation opens new avenues for therapeutic intervention against cancers...
  26. pmc Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1
    Michael J Flister
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794 9626, USA
    Blood 115:418-29. 2010
    ..We also show that Prox1 synergizes with the p50 of NF-kappaB to control VEGFR-3 expression...
  27. ncbi To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosis
    Jérôme Kucharczak
    Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, NJ, USA
    Oncogene 22:8961-82. 2003
    ....
  28. ncbi Polymorphism in the promoter region of the NFKB1 gene increases the risk of sporadic colorectal cancer in Swedish but not in Chinese populations
    Andreas Lewander
    Department of Oncology, Institute of Biomedicine and Surgery, University of Linkoping, Linkoping, Sweden
    Scand J Gastroenterol 42:1332-8. 2007
    ..The purpose of this study was to investigate whether this polymorphism is related to colorectal cancer risk and clinicopathological variables...
  29. pmc NF-kappaB as a critical link between inflammation and cancer
    Michael Karin
    Department of Pharmacology and Pathology, Moores Cancer Canter, UCSD School of Medicine, La Jolla, California 92093 0723, USA
    Cold Spring Harb Perspect Biol 1:a000141. 2009
    ..Most importantly, through its ability to up-regulate the expression of tumor promoting cytokines, such as IL-6 or TNF-alpha, and survival genes, such as Bcl-X(L), NF-kappaB provides a critical link between inflammation and cancer...
  30. ncbi Human immunodeficiency virus type 1 Nef mediates activation of STAT3 in immature dendritic cells
    D Messmer
    North Shore LIJ Research Institute, Manhasset, New York 11030, USA
    AIDS Res Hum Retroviruses 18:1043-50. 2002
    ..This highlights how Nef can signal primary immature DCs, suggesting one way in which Nef may modulate immature DCs to drive virus replication in the DC-T cell milieu...
  31. ncbi Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Mol Med 21:577-84. 2008
    ..In conclusion, hydroxylated triterpenes from G. lucidum could be promising natural agents for the therapy of invasive breast cancers...
  32. pmc Follicular dendritic cells and human immunodeficiency virus type 1 transcription in CD4+ T cells
    Tyler C Thacker
    Department of Chemistry and Biochemistry, Room C 211A BNSN, Brigham Young University, Provo, UT 84602, USA
    J Virol 83:150-8. 2009
    ..Therefore, in addition to providing an important reservoir of infectious virus, FDCs increase HIV production, contributing to a tissue microenvironment that is highly conducive to HIV transmission and expression...
  33. doi Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells
    Shue Fen Luo
    Department of Internal Medicine, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    Toxicol Appl Pharmacol 237:8-21. 2009
    ..Blockade of these pathways may reduce monocyte adhesion via VCAM-1 suppression and attenuation of the inflammatory responses in airway diseases...
  34. doi Clinorotation upregulates inducible nitric oxide synthase by inhibiting AP-1 activation in human umbilical vein endothelial cells
    Yong Chun Wang
    Department of Aerospace Biodynamics, Fourth Military Medical University, Xi an, China
    J Cell Biochem 107:357-63. 2009
    ..These findings indicate that clinorotation upregulates iNOS in HUVECs by a mechanism dependent on suppression of AP-1, but not NF-kappaB. These results support a key role for AP-1 in the signaling of postflight orthostatic intolerance...
  35. doi Functions of Tat: the versatile protein of human immunodeficiency virus type 1
    Bizhan Romani
    Division of Medical Virology, Department of Pathology, University of Stellenbosch, Tygerberg 7505, South Africa
    J Gen Virol 91:1-12. 2010
    ..Due to its pivotal role in viral replication and in disease pathogenesis, Tat and the cellular pathways targeted by Tat are potential targets for new anti-HIV drugs...
  36. pmc Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy
    Jiajia Ma
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    J Biol Chem 284:34600-6. 2009
    ..Consequently, knockdown of EGR-1 inhibited IL-8-mediated tumor colony formation and invasion. Thus, targeted knockdown of EGR-1 could be an effective therapeutic approach against prostate cancer...
  37. pmc Differential cytokine regulation by NF-kappaB and AP-1 in Jurkat T-cells
    Hazem Khalaf
    Biology, Orebro Life Science Center, School of Science and Technology, Orebro University, SE 701 82 Orebro, Sweden
    BMC Immunol 11:26. 2010
    ..The aim of this study was to investigate the role of the transcription factors, AP-1 and NF-kappaB, in IL-6 and CXCL8 regulation in Jurkat T-cells...
  38. doi DNA-dependent activator of IFN-regulatory factors enhances the transcription of HIV-1 through NF-κB
    Takaya Hayashi
    Department of Immunotherapeutics, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Microbes Infect 12:937-47. 2010
    ..These results suggest that activation of DAI might contribute to augment HIV-1 replication through DAI- NF-κB pathway...
  39. doi Nonstructural protein 1α subunit-based inhibition of NF-κB activation and suppression of interferon-β production by porcine reproductive and respiratory syndrome virus
    Cheng Song
    Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Virology 407:268-80. 2010
    ..Our results suggest that PRRSV Nsp1α is a multifunctional nuclear protein participating in the modulation of the host IFN system...
  40. pmc HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-κB pathway and can be silenced by gp120-specific siRNA
    Ankit Shah
    Division of Pharmacology and Toxicology, UMKC School of Pharmacy, Kansas City, MO 64108, USA
    J Neuroinflammation 7:96. 2010
    ..In this study, we sought to address whether HIV-1gp120 could affect IL-8 expression in astrocytes and whether the NF-κB pathway is involved in this phenomenon...
  41. pmc PU.1 and C/EBP(alpha) synergistically program distinct response to NF-kappaB activation through establishing monocyte specific enhancers
    Fulai Jin
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:5290-5. 2011
    ..These results suggest that the diversity of transcriptional programs in mammalian cells arises, at least in part, from preexisting enhancers that are established by cell-specific transcription factors...
  42. pmc Nuclear factor-κB-dependent epithelial to mesenchymal transition induced by HIF-1α activation in pancreatic cancer cells under hypoxic conditions
    Zhuo Xin Cheng
    Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People s Republic of China
    PLoS ONE 6:e23752. 2011
    ..Compared with HIF-1α, the correlation between NF-κB and EMT during hypoxia has been less studied, and although the phenomenon was observed in the past, the molecular mechanisms involved remained unclear...
  43. pmc Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65
    Giuseppe Fiume
    Department of Experimental and Clinical Medicine, University of Catanzaro Magna Graecia, Viale Europa Germaneto, 88100 Catanzaro, Italy
    Nucleic Acids Res 40:3548-62. 2012
    ..Our results support a novel mechanism of NF-κB activation via physical interaction of Tat with IκB-α and p65, and may contribute to further insights into the deregulation of the inflammatory response by HIV-1...
  44. pmc An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation
    Alfonso Lavorgna
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida, USA
    J Virol 86:3357-69. 2012
    ..Together, these results reveal that the deubiquitinase STAMBPL1 is a key regulator of Tax trafficking and function...
  45. ncbi Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase
    Jui Hsiang Hung
    Department of Biochemistry, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan, Republic of China
    J Biol Chem 279:46384-92. 2004
    ..Our results provide important insights into cellular carcinogenesis associated with latent endoplasmic reticulum stress...
  46. ncbi Good cop, bad cop: the different faces of NF-kappaB
    N D Perkins
    Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, MSI WTB complex, Dow Street, Dundee, Scotland DD1 5EH, UK
    Cell Death Differ 13:759-72. 2006
    ....
  47. pmc Inhibition of NF-kappaB-dependent transcription by MKP-1: transcriptional repression by glucocorticoids occurring via p38 MAPK
    Elizabeth M King
    Airways Inflammation Group, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 284:26803-15. 2009
    ..We conclude that GR transactivation is essential to the anti-inflammatory properties of GR ligands...
  48. pmc Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development
    Kieng B Vang
    Department of Laboratory Medicine and Pathology, The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 184:4074-7. 2010
    ..We demonstrate that c-Rel, but not NF-kappaB1, promotes the development of Treg progenitors. Thus, a CD28/c-Rel-dependent pathway is involved in initiating Treg development...
  49. ncbi NF-kappaB activation and overexpression of regulated genes in human diabetic nephropathy
    Sergio Mezzano
    Department of Nephrology, School of Medicine, Universidad Austral Bueras 1003 2 P, PO Box 8 D, Valdivia, Chile
    Nephrol Dial Transplant 19:2505-12. 2004
    ..It has been proposed that locally produced MCP-1 may be involved in the development of diabetic nephropathy (DN). We examined the hypothesis that NF-kappaB could be an indicator of renal damage progression in DN...
  50. doi NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells
    Harald J Maier
    Institute of Physiological Chemistry, University of Ulm, Germany
    Cancer Lett 295:214-28. 2010
    ..EMT could also be induced in cells with defective TGF-beta signalling. Functional assays demonstrated reduced or strongly enhanced migration and invasion upon NF-kappaB inhibition or activation, respectively...
  51. pmc The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations
    Ulla Vogel
    National Research Centre for the Working Environment, Copenhagen, Denmark
    Atherosclerosis 219:200-4. 2011
    ..A common deletion-allele in the promoter region of NFKB1 results in lower protein levels of the NF-κB p50 subunit. Recent evidence suggests that the NF-κB p50 dimer has anti-inflammatory effects...
  52. pmc HIV latency
    Robert F Siliciano
    Department of Medicine, Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Baltimore, Maryland 21205, USA
    Cold Spring Harb Perspect Med 1:a007096. 2011
    ..Several approaches are under exploration for reactivating latent virus with the hope that this will allow elimination of the latent reservoir...
  53. ncbi Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid
    Rentian Feng
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 280:27888-95. 2005
    ....
  54. pmc Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages
    Laura Fantuzzi
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Blood 111:3355-63. 2008
    ....
  55. pmc TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL
    Matthew C Walsh
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    PLoS ONE 3:e4064. 2008
    ..the TAK1-TAB1-TAB2 complex, but surprisingly was also found to be fully competent to activate TAK1, as well as NFkappaB and AP-1 reporters...
  56. pmc The prognostic impact of TGF-β1, fascin, NF-κB and PKC-ζ expression in soft tissue sarcomas
    Andrej Valkov
    Department of Clinical Pathology, University Hospital of Northern Norway, Tromsø, Norway
    PLoS ONE 6:e17507. 2011
    Transforming growth factor-β (TGF-β), fascin, nuclear factor-kappa B (NF-κB) p105, protein-kinase C-zeta (PKC-ζ), partioning-defective protein-6 (Par-6), E-cadherin and vimentin are tumor promoting molecules through mechanisms ..
  57. pmc NF-kappa B inhibition causes spontaneous apoptosis in Epstein-Barr virus-transformed lymphoblastoid cells
    E D Cahir-McFarland
    The Channing Laboratory and Department of Infectious Diseases, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02130, USA
    Proc Natl Acad Sci U S A 97:6055-60. 2000
    ..However, caspase inhibition failed to block apoptosis. These experiments indicate that NF-kappaB inhibitors may be useful in the therapy of EBV-induced cellular proliferation...
  58. ncbi Functional polymorphism in NFKB1 promoter is related to the risks of oral squamous cell carcinoma occurring on older male areca (betel) chewers
    Shu Chun Lin
    School of Dentistry, National Yang Ming University, Li Nong St, Sec 2, Taipei 112, Taiwan, ROC
    Cancer Lett 243:47-54. 2006
    ..NFKB1 encodes a 105kDa protein that can be processed to produce p50 subunit of nuclear factor-kappaB protein complex...
  59. doi RelA/NF-kappaB transcription factor associates with alpha-actinin-4
    Vladimir N Babakov
    Department of Cell Cultures, Institute of Cytology, St Petersburg, Russian Federation
    Exp Cell Res 314:1030-8. 2008
    ..Affinity chromatography experiments displayed that p65 and p50 subunits of NF-kappaB can bind to matrix-bound chicken gizzard alpha-actinin...
  60. doi The interaction of nuclear factor-kappa B and cytokines is associated with schizophrenia
    Xue Qin Song
    Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    Biol Psychiatry 65:481-8. 2009
    ..However, it remains unclear whether the interaction between NF-kappaB and cytokines is implicated in schizophrenia and whether the effect of neuroleptics treatment for 4 weeks is associated with the alteration of cytokines...
  61. ncbi Airway epithelium controls lung inflammation and injury through the NF-kappa B pathway
    Dong Sheng Cheng
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 178:6504-13. 2007
    ....
  62. doi Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1
    Devanand Sarkar
    Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York, USA
    Cancer Res 68:1478-84. 2008
    ..In these contexts, AEG-1 represents a viable potential target for the therapy of malignant glioma...
  63. pmc Inflammation anergy in human intestinal macrophages is due to Smad-induced IkappaBalpha expression and NF-kappaB inactivation
    Lesley E Smythies
    Department of Medicine Gastroenterology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 285:19593-604. 2010
    ..Our findings implicate stromal transforming growth factor-beta-induced dysregulation of NF-kappaB proteins and Smad signaling in the differentiation of pro-inflammatory blood monocytes into noninflammatory intestinal macrophages...
  64. ncbi TNFR1-induced NF-kappaB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells
    Zhigang Zhou
    School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, NR4 7TJ, United Kingdom
    Cell Signal 19:1238-48. 2007
    ....
  65. doi Role of osteopontin in induction of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta through the NF-kappaB and MAPK pathways in rheumatoid arthritis
    Wenxin Zheng
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Arthritis Rheum 60:1957-65. 2009
    ..In this study, we investigated the role and molecular mechanism of OPN in the induction of 2 key chemokines, monocyte chemoattractant protein 1 (MCP-1) and macrophage inflammatory protein 1beta (MIP-1beta), in RA...
  66. ncbi NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway
    S C Sun
    Gladstone Institute of Virology and Immunology, University of California, San Francisco
    Science 259:1912-5. 1993
    ..Together, these results show that NF-kappa B controls the expression of I kappa B alpha by means of an inducible autoregulatory pathway...
  67. ncbi Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation
    Gongxian Liao
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 279:26243-50. 2004
    ..These results suggest that induction of noncanonical NF-kappaB signaling may involve the rescue of NIK from TRAF3-mediated negative regulation...
  68. ncbi Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis
    Shiyong Wu
    Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Biol Chem 279:34898-902. 2004
    UV light induces a delayed and prolonged (3-20 h) activation of NFkappaB when compared with the immediate and acute (10-90 min) activation of NFkappaB in response to tumor necrosis factor alpha treatment...
  69. doi Functional polymorphism of NFKB1 promoter may correlate to the susceptibility of gastric cancer in aged patients
    Su Shun Lo
    Department of Surgery, National Yang Ming University Hospital, I Lan, Taiwan
    Surgery 145:280-5. 2009
    ..This study investigated whether a common insertion (ins)/deletion (del) polymorphism (-94 ins/del ATTG) in the NFKB1 promoter is associated with susceptibility to gastric cancer and its tumor behavior...
  70. doi Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity
    Jing Xue
    Key Laboratory of Nutrition and Metabolisms, Institute of Nutritional Sciences, SIBS, Chinese Academy of Sciences, Shanghai, China
    Gastroenterology 138:606-15. 2010
    ..However, the expression pattern of PHDs in colorectal cancer and the correlation between their expression level and tumorigenesis is unclear...
  71. ncbi ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB
    Claudio Mauro
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Federico II, University of Naples, Via S Pansini, 5, 80131 Naples, Italy
    J Biol Chem 281:18482-8. 2006
    ..Altogether our data indicate that ABIN-1 physically links A20 to NEMO/IKKgamma and facilitates A20-mediated de-ubiquitination of NEMO/IKKgamma, thus resulting in inhibition of NF-kappaB...
  72. doi Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells
    C Jennewein
    University Children s Hospital, Ulm, Germany
    Oncogene 31:1468-74. 2012
    ..Thus, this study demonstrates for the first time that NF-κB exerts a pro-apoptotic role in TRAIL- and CD95-induced apoptosis in glioblastoma cells by facilitating DISC formation...
  73. pmc Neuroepithelial transforming gene 1 (Net1) binds to caspase activation and recruitment domain (CARD)- and membrane-associated guanylate kinase-like domain-containing (CARMA) proteins and regulates nuclear factor κB activation
    Mariangela Vessichelli
    Dipartimento di Scienze Biologiche ed Ambientali, Universita degli Studi del Sannio, Via Port Arsa 11, 82100 Benevento, Italy
    J Biol Chem 287:13722-30. 2012
    ..Thus, this study identifies Net1 as a CARMA-interacting molecule and brings important information on the molecular mechanisms that control NF-κB transcriptional activity...
  74. ncbi Nuclear factor-kB signaling pathway constitutively activated in esophageal squamous cell carcinoma cell lines and inhibition of growth of cells by small interfering RNA
    Fang Tian
    Laboratory for Cell Biology, Medical College, Zhengzhou University, Zhengzhou 450052, China
    Acta Biochim Biophys Sin (Shanghai) 38:318-26. 2006
    ..The results showed that p50, p65, IkappaBalpha p-IkappaBalpha and IkappaB kinase beta were expressed and mainly localized in the cytoplasm...
  75. ncbi Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB
    Terence T Chiu
    Dept of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1786, USA
    Am J Physiol Cell Physiol 292:C767-77. 2007
    ..Our results demonstrate, for the first time, the involvement of a member of the PKD family in the production of IL-8, a potent proinflammatory chemokine, by epithelial cells...
  76. pmc Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia
    Shujun Liu
    Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
    Blood 111:2364-73. 2008
    ..Our results unveil the Sp1/NF-kappaB pathway as a modulator of DNA methyltransferase activity in human cancer and identify bortezomib as a novel epigenetic-targeting drug...
  77. doi Genome-scale RNAi screen for host factors required for HIV replication
    Honglin Zhou
    Department of Virus and Cell Biology, Merck and Co, Inc, West Point, PA 19486, USA
    Cell Host Microbe 4:495-504. 2008
    ..This study highlights both the power and shortcomings of large scale loss-of-function screens in discovering host-pathogen interactions...
  78. pmc A vaccinia virus deletion mutant reveals the presence of additional inhibitors of NF-kappaB
    Katharine Fagan-Garcia
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Virol 85:883-94. 2011
    ..Correspondingly, coimmunoprecipitation assays demonstrated that the NF-κB-inhibitory IκBα-p65-p50 complex was intact in VV811-infected cells...
  79. pmc ΔNp63 versatilely regulates a Broad NF-κB gene program and promotes squamous epithelial proliferation, migration, and inflammation
    Xinping Yang
    Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 71:3688-700. 2011
    ..Our study reveals ΔNp63 as a master transcription factor that, in coordination with NF-κB/Rels, orchestrates a broad gene program promoting epidermal hyperplasia, inflammation, and the malignant phenotype of HNSCC...
  80. pmc TAK1 regulates NF-ΚB and AP-1 activation in airway epithelial cells following RSV infection
    Nilay Dey
    Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA
    Virology 418:93-101. 2011
    ....
  81. doi The NFKB1 promoter polymorphism (-94ins/delATTG) alters nuclear translocation of NF-κB1 in monocytes after lipopolysaccharide stimulation and is associated with increased mortality in sepsis
    Michael Adamzik
    Klinik für Anästhesiologie und Intensivmedizin, Universitat Duisburg Essen, Universitatsklinikum Essen, Essen, Germany
    Anesthesiology 118:123-33. 2013
    ....
  82. doi Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks
    Justin A Green
    Department of Infectious Diseases and Immunity, Hammersmith Campus, Imperial College London, London, United Kingdom
    J Immunol 184:6492-503. 2010
    ..Dexamethasone suppression of MMP-1/-3 gene expression provides a novel mechanism explaining the benefit of steroid therapy in these patients...
  83. doi Connective tissue growth factor enhances the migration of gastric cancer through downregulation of E-cadherin via the NF-κB pathway
    Zhengfa Mao
    Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China
    Cancer Sci 102:104-10. 2011
    ..Collectively, these data reported here demonstrate CTGF could modulate the NF-κappaB pathway and perhaps be a promising therapeutic target for gastric cancer invasion and metastasis...
  84. pmc Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha
    V Heissmeyer
    Max Delbruck Center for Molecular Medicine, 13122 Berlin, Germany
    Mol Cell Biol 21:1024-35. 2001
    b>p105 (NFKB1) acts in a dual way as a cytoplasmic IkappaB molecule and as the source of the NF-kappaB p50 subunit upon processing...
  85. pmc Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation
    Manabu Minami
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Biol Chem 283:9692-703. 2008
    ..that PGE(2) pretreatment selectively inhibits lipopolysaccharide (LPS)-induced nuclear factor kappaB1 (NF-kappaB1) p105 phosphorylation and degradation in mouse bone marrow-derived macrophages through EP4-dependent mechanisms...
  86. ncbi 3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling
    Hiroshi Tanaka
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113 0032, Japan
    J Biol Chem 280:40965-73. 2005
    ..These results indicate that PDK1 is a critical regulator of cell survival by modulating the IKK/NF-kappaB pathway in addition to the Akt pathway...
  87. pmc Betulinic acid suppresses constitutive and TNFalpha-induced NF-kappaB activation and induces apoptosis in human prostate carcinoma PC-3 cells
    Thangaiyan Rabi
    Department of Urology, The James and Eillen Dicke Research Laboratory, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Mol Carcinog 47:964-73. 2008
    ..Our studies demonstrate that BetA effectively inhibits constitutive NF-kappaB activation and supports the rationale for targeting NF-kappaB through combination protocols with BetA in androgen-refractory prostate cancer...
  88. pmc Inhibiting TRAF2-mediated activation of NF-kappaB facilitates induction of AP-1
    Sunil K Manna
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nampally, Hyderabad 500 001, India
    J Biol Chem 285:11617-27. 2010
    ..These results suggest novel approaches to design of P(3)-25 as an anti-cancer/inflammatory drug for therapy through regulation of the TRAF2 pathway...
  89. pmc Interleukin-27 induces a STAT1/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes
    Christina Guzzo
    Department of Microbiology and Immunology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    J Biol Chem 285:24404-11. 2010
    ..Understanding how IL-27 exerts its effects on monocytic cells will identify important molecular mechanisms in the regulation of immune responses, particularly in the modulation of monocyte activation...
  90. pmc BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1
    Aurore Keutgens
    Interdisciplinary Cluster for Applied Genoproteomics, GIGA Research, Unit of Medical Chemistry, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, University of Liege, Sart Tilman, 4000 Liege, Belgium
    J Biol Chem 285:25831-40. 2010
    The oncogenic protein BCL-3 activates or represses gene transcription through binding with the NF-kappaB proteins p50 and p52 and is degraded through a phospho- and GSK3-dependent pathway...
  91. pmc Regulation of NFKB1 proteins by the candidate oncoprotein BCL-3: generation of NF-kappaB homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation
    N Watanabe
    Department of Tumor Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo, Japan
    EMBO J 16:3609-20. 1997
    ..Co-transfection and in vitro reconstitution experiments revealed that the complex of p50 with its precursor p105 (p50-p105), which was shown to accumulate in the cytoplasm of the pro-B cell lines, is required for induction of ..
  92. ncbi LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappaB activation
    Andy Wullaert
    Unit of Molecular Signal Transduction in Inflammation, Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology, Ghent University, Belgium
    J Biol Chem 282:81-90. 2007
    ..Taken together, these results implicate ABIN-3 as a novel negative feedback regulator of LPS-induced NF-kappaB activation...
  93. doi A functional insertion/deletion polymorphism in the promoter region of NFKB1 gene increases susceptibility for nasopharyngeal carcinoma
    Bin Zhou
    Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, PR China
    Cancer Lett 275:72-6. 2009
    ..insertion/deletion polymorphism (-94 insertion/deletion ATTG) in the promoter of NFKB1 gene, which encodes the p50 subunit of NF-kappaB protein complex, was recently identified...
  94. pmc NF-kappaB and phosphatidylinositol 3-kinase activity mediates the HCMV-induced atypical M1/M2 polarization of monocytes
    Gary Chan
    Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
    Virus Res 144:329-33. 2009
    ....
  95. doi Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-kappaB activity
    Tomohiro Kabuta
    Departments of Animal Sciences and Applied Biological Chemistry, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Biochem Biophys Res Commun 394:697-702. 2010
    ..Bcl-3 is a nuclear protein, which forms a complex with the homodimer of p50 NF-kappaB, leading to enhancement of transcription through p50 NF-kappaB...
  96. pmc The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1
    Daniel Krappmann
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Mol Cell Biol 24:6488-500. 2004
    ..Thus, our data illustrate that NF-kappaB orchestrates immediate-early effects of LPS signaling and controls secondary AP-1 activation to mount an appropriate biological response...
  97. ncbi The C-terminal activating region 2 of the Epstein-Barr virus-encoded latent membrane protein 1 activates NF-kappaB through TRAF6 and TAK1
    Liming Wu
    Department of Biochemistry, Hong Kong University of Science and Technology, Clearwater Bay, Kowloon, Hong Kong, China
    J Biol Chem 281:2162-9. 2006
    ..Thus, LMP1 utilizes two distinct pathways to activate NF-kappaB: a major one through CTAR2/TRAF6/TAK1/IKKbeta (canonical pathway) and a minor one through CTAR1/TRAF3/NIK/IKKalpha (noncanonical pathway)...
  98. pmc Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma
    Cristiane H Squarize
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4340, USA
    Neoplasia 8:733-46. 2006
    ..signaling routes, including signal transducer and activator of transcription-3 (STAT3), nuclear factor kappaB (NFkappaB), and Akt...
  99. doi A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas
    Tin Lap Lee
    Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892 1419, USA
    Int J Cancer 122:1987-98. 2008
    ..Inhibition of signal activation of both NF-kappaB and STAT3 together with reexpression of p53 could be the most effective strategy to restore BAX/BCL-XL regulation and for cytotoxic therapy of HNSCC...
  100. pmc Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion
    Yadi Wu
    Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Cancer Cell 15:416-28. 2009
    ..Our study provides a plausible mechanism for inflammation-induced metastasis...
  101. pmc Activation of transcription factor NF-kappaB by the Tat protein of human immunodeficiency virus type 1
    F Demarchi
    International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    J Virol 70:4427-37. 1996
    ..These results show that NF-kappaB activation by Tat is important for LTR transcriptional activation. Furthermore, they suggest that some of the pleiotropic effects of Tat on cellular functions can be mediated by induction of NF-kappaB...

Research Grants69

  1. INDER MOHAN VERMA; Fiscal Year: 2014
    ..We propose to study the molecular mechanism of inflammatory processes by studying the regulation of NF-?B a seminal molecule in the induction of inflammation. ..
  2. Hypothermia enhances inflammatory cytokine expression via NF-kappa B
    Karen D Fairchild; Fiscal Year: 2010
    ..into an independent investigator elucidating the cellular, molecular, and in vivo effects of hypothermia on NF kappa B-dependent gene expression...
  3. Androgen Receptor-JunD Complex Inhibitors to Prevent Prostate Cancer Progression
    Hirak S Basu; Fiscal Year: 2012
    ..The most active agent, thus identified, can be further developed for preclinical and clinical testing to prevent progression of early-stage androgen-dependent PCa to CRPCa. ..
  4. Effect of beta-glucan on sepsis
    COURTNI NEWSOME; Fiscal Year: 2009
    ..The potential development of beta-glucan as a therapeutic agent with negligible side effects could aid immunocompromised patients, including those undergoing chemotherapy and those with uncontrolled inflammation. ..
  5. Cohort Study of Glucosamine and Chondroitin Supplement Use and Cancer Risk
    Emily White; Fiscal Year: 2012
    ..In addition, if there are observed protective associations of glucosamine and/or chondroitin with cancer risk and no major adverse effects, then these supplements would deserve further investigation as cancer preventive drugs. ..
  6. Sp1, kappa-B enhancers and transcriptions in neurons
    STEVEN BARGER; Fiscal Year: 2009
    ..abstract_text> ..
  7. Stuart B Goodman; Fiscal Year: 2016
    ..The proposed research is important, innovative and clinically relevant;it will suggest potential local pharmacological strategies to mitigate the chronic inflammatory reaction to wear particles and periprosthetic osteolysis. ..
  8. Gourisankar Ghosh; Fiscal Year: 2016
    ..The combinatorial NF-?B dimers are formed from five family members;p50, p52, RelA (p65), cRel and RelB...
  9. Gourisankar Ghosh; Fiscal Year: 2015
    ..NF-?B1 (also called p105/p50) and NF-?B2 (also called p100/p52) belong to both the NF-?B and I?B families...
  10. NF kappa B Activity in Skin Inflammation and Carcinogenesis
    Brian Poligone; Fiscal Year: 2013
    ..It is through this basic understanding of skin disease that better treatments of can be identified. ..
  11. Effect of constitutive Type 2 NF-kB on adipogenesis
    LOTUS KYI LOO; Fiscal Year: 2010
    ....
  12. CHARLES EMORY MCCALL; Fiscal Year: 2014
    ..From these results, novel therapeutic interventions or preventions may be designed to improve the poor outcomes associated with SSI. ..
  13. Breast Cancer Survivors: Physical Activity, Inflammation, Fatigue, and Distress
    Janice K Kiecolt-Glaser; Fiscal Year: 2012
    ....
  14. Anna K Mapp; Fiscal Year: 2016
    ..small (drug-like) molecules that inhibit the function of two transcriptional activators, ESX and NF- kappaB (p50/p65 heterodimer) implicated in approximately 30% of breast cancers...
  15. Synapt G2-S System with HXMS Automation
    Elizabeth A Komives; Fiscal Year: 2013
    ....
  16. Jennifer C Condon; Fiscal Year: 2014
    ....
  17. Non-Canonical NF-kappaB Signaling In Endothelial Cells
    Michael J May; Fiscal Year: 2010
    ..This proposal will investigate the signals that control blood vessel activation and will therefore identify novel drug targets for preventing or treating chronic inflammation. ..
  18. Matthew B Rettig; Fiscal Year: 2015
    ..Specifically, we found that the HPV-encoded E6 protein mediates prolonged activation of the NF kappa B (NF-:B) signaling pathway under hypoxic conditions...
  19. Jeffrey L Staudinger; Fiscal Year: 2014
    ....
  20. SHANNON CELESTE KENNEY; Fiscal Year: 2016
    ....
  21. MOLECULAR CONTROL OF LIVER REGENERATION
    Rebecca Taub; Fiscal Year: 2000
    ..PHF/NF-Kappa B by analyzing the regenerative capacity of mouse livers from animals that are genetically missing the p50 subunit of PHF/NF-Kappa B...
  22. Poxvirus regulation of NF-kB: Mechanisms for virulence
    Joanna Shisler; Fiscal Year: 2009
    ..Results obtained here may prove useful in devising novel strategies to overcome pathogenic effects of vaccinia, with implications for enhancing safety and efficacy of a smallpox vaccine. ..
  23. Use p105(sr) to study p50 homodimer in skin tumor/cancer
    Li Lin; Fiscal Year: 2009
    ..We have developed an NF-kappaB super represser based on NF-kappaB inhibitor p105, and demonstrated that p105(sr) broadly and effectively inhibits all NF-kappaB species...
  24. REGULATION OF NF-KAPPA B BY NITRIC OXIDE IN THE LUNG
    HARVEY MARSHALL; Fiscal Year: 2004
    ..We hypothesize that NO regulates NF-Kappa B via the formation of a nitrosothiol on the p50-p65 heterodimer or another protein in the activation pathway. To investigate this hypothesis we plan to: 1...
  25. Sophia Ran; Fiscal Year: 2014
    ..is also presented that in lymphatic endothelial cells (LECs) VEGFR-3 expression might be regulated by both the p50 subunit of NF-?B and the lymphatic-specific transcription factor, Prox1...
  26. HIF-1-Regulated Endothelial Progenitor Cell Recruitment in Burn Wound Healing
    Gregg L Semenza; Fiscal Year: 2010
    ..described above, which will provide the scientific foundation for clinical trials to be proposed in a subsequent P50 application, which will be submitted during year 3 of P20 funding and will lead to novel treatments to promote ..
  27. Shao Cong Sun; Fiscal Year: 2016
    ..Interestingly, Tpl2 is sequestered by an I(B-like molecule, p105, and the activation of Tpl2 requires IKK-mediated p105 phopshorylation and degradation...
  28. Cytoprotective cytokine signaling and reperfusion injury
    DOUGLAS LOWELL MANN; Fiscal Year: 2010
    ..are the cytoprotective effects of TRAF2 mediated by activation of the type 1 NF-?B pathway, and if so are p65 and p50 homo or heterodimers involved (Specific Aim 1)? Second, is dysferlin necessary for the cytoprotective effects of ..
  29. Suzanne Gaudet; Fiscal Year: 2016
    ..Finally, we will use protein-binding microarrays to ask how competition between p65-p50 heterodimers and p50-p50 homodimers contributes to decoding NF-kB activation and to cell line-to-cell line ..
  30. ONCOGENIC RAS REQUIRES NFKB ANTIAPOPTOTIC FUNCTION
    MARTY MAYO; Fiscal Year: 2003
    ..factor is known to play a critical role in regulating immune responses, recent evidence has suggested that NF kappa B may be important for oncogene-mediated transformation...
  31. Inflammatory regulation of lipid accumulation in skeletal muscle with obesity
    Matthew W Hulver; Fiscal Year: 2012
    ..Specific Aim 2 proposes the use of TLR4 mutant (C3H/HeJ) and NF-kB knockout (nfkb1- p105) animals to demonstrate that both TLR4 and NF-kB are critically important for SCD1 regulation...
  32. Mechanisms of Reovirus-Induced Apoptosis
    Terence S Dermody; Fiscal Year: 2011
    ..Following reovirus infection, mice deficient in the p50 subunit of NF-icB display diminished apoptosis in the brain, yet enhanced apoptosis in the heart, as compared to ..
  33. Role of Mitochondrial Respiratory Stress Signaling in Cancer Progression
    Narayan G Avadhani; Fiscal Year: 2013
    ..hnRNPA2, a common transcription co-activator that functionally synergizes the activity of promoter bound cRel/p50, C/EBP[unreadable], CREB and NFAT transcription factors...
  34. Finding Small Molecules that Modulate Gene Expression
    Philip H Bolton; Fiscal Year: 2010
    ..are many neurological transcription systems that may be amenable to this approach including the c-Rel, RelA and p50 heterodimer and homodimer transcription factors as well as those of the CREB and CREM transcription factors that ..
  35. Suppression of HIV-1 in CNS by a novel protein from ST John's Wort
    Shohreh Amini; Fiscal Year: 2010
    ..Earlier studies have ascribed important roles for several transcription factors such as the C/EBPa family, NFkB (p50/p65), and the viral transactivator, Tat, and the late auxiliary protein, Vpr, in these cells...
  36. Inhibition of Microflora-Induced Colitis by NF-kB
    Bruce H Horwitz; Fiscal Year: 2010
    ..Mice lacking the p50/p105 subunit of NF-(B are sensitized to the development of colitis, due at least in part to a defect within ..
  37. Novel Subunit of NF-kB Confers Gene Regulatory Specificity
    Fengyi Wan; Fiscal Year: 2013
    ..the original size estimate of native NF-kB in nuclear extracts was >200 kD, but when reconstituted from purified p50 and p65 proteins, it was estimated to be 115 kD which would be appropriate for a simple heterodimer, 2) ..
  38. Mechanisms of constitutive NF-kB activity
    Shigeki Miyamoto; Fiscal Year: 2009
    ..Two major NF-[unreadable]B complexes are p65:p50 and cRel:p50 heterodimers. Depending on cellular context, one or both of these can be constitutively activated...
  39. Mechanisms of H. pylori-Induced Hypochlorhydria
    Adam J Smolka; Fiscal Year: 2010
    ..pylori cag PAI genes repress HK1 promoter constructs transfected into gastric cells by promoting NF-:B p50 homodimer binding to an HK1 cis-response element...
  40. Role of cGMP in Ventilator-Induced Lung Endothelial Barrier Dysfunction
    David B Pearse; Fiscal Year: 2013
    ..of TNFa, p38, MK2 and NF?B using specific inhibitors, siRNA, as well as TNFa -/-, TNFa Receptor1-/-, MK2-/-, and p50-/- mice to dissect the involvement of each signaling pathway...
  41. Grant McFadden; Fiscal Year: 2016
    ..ASC-1 (apoptosis-associated speck-like protein containing a CARD) of various inflammasome complexes and NF-?B1/p105 of NF-?B signaling pathway...
  42. NANCY JOAN RAAB-TRAUB; Fiscal Year: 2014
    ..Our specific aims are: 1.) Identify the epithelial cellular targets that are regulated by LMP1-CTAR1 through the p50/p50-Bcl-3 transcriptional complex and activated STAT3 using chromatin immunoprecipitation (ChIP) analysis and ChIP-..
  43. Emiko Mizoguchi; Fiscal Year: 2015
    ..We believe that the study proposed would provide important intervention to develop a novel immune therapy for resolving diverse health problems, including infection, autoimmune diseases, cancer, and atherosclerosis. ..
  44. Effects of UBS109, a novel NF-kappaBeta inhibitor, on depressive-like behaviors
    ANLYS OLIVERA; Fiscal Year: 2010
    ....
  45. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..carried out at 3 time points: at 1 h post reperfusion for I?B[unreadable], phosphorylation of MAP kinases, nuclear p50;at 3 h post reperfusion for RT-PCR to quantify lung mRNA concentrations of TNF-[unreadable], MIP-1[unreadable], and ..
  46. Hybrid Katp Channel Opener and Redox Catalyst for Lung Transplantation
    Prakash Jagtap; Fiscal Year: 2013
    ..Specific analyses will be carried out at 3 time points: at 1 h post reperfusion for IkB[unreadable], nuclear p50, and phosphorylation of mitogen activated protein kinases (MAPKs - ERK, p38, JNK);at 3h post reperfusion for RT-PCR ..
  47. Stephanie A Shore; Fiscal Year: 2016
    ..We will use EMSA and Western blotting for I?B, p50, and p65 to determine O3-induced NF-?B activation is increased in obese mice...
  48. Kara Gross Margolis; Fiscal Year: 2016
    ..scores, intestinal expression of genes encoding proinflammatory molecules, levels of neutrophil elastase and p50 NF B) of TNBS- and DSS-induced colitis are higher in NSE- noggin and lower in Hand2+/- mice than in their wild-type ..
  49. MOLECULAR GENETIC EPIDEMIOLOGY OF CLEFT LIP AND PALATE
    Jeffrey C Murray; Fiscal Year: 2013
    ..to secure funding for ultrasound and 3D facial imaging instruments as part of a supplement to our now expiring P50 grant but there are no funds to subphenotype beyond this year, We will do the 3D imaging, 00 ultrasounds, dental ..
  50. Curcumin and chemoprevention of H. pylori-associated gastric carcinogenesis
    Rupesh Chaturvedi; Fiscal Year: 2013
    ..pylori activated Macs to a tolerant regulatory phenotype in a NF-kB1 (p105/p50)-dependent manner. Tolerance may lead to persistence of H...
  51. Bridget S Wilson; Fiscal Year: 2016
    ..This application proposes the STMC for recognition as the first P50 National Center for Systems Biology in the Southwestern USA...
  52. A Novel Human DNA Damage Response Which Directly Alters DNA Polymerase Delta
    CHRISTINE ELIZABETH LEROY; Fiscal Year: 2013
    ..The enzyme consists of four subunits: p125 and p50 which make up the catalytic core, and p68 and p12, which provide the enzyme increased stability, enhanced activity, ..
  53. Floyd H Chilton; Fiscal Year: 2014
    ..provided by applicant): The Center for Botanical Lipids and Inflammatory Disease Prevention is a new version of a P50 at Wake Forest University Health Sciences that has been continuously funded since 2005...
  54. Christopher A Klug; Fiscal Year: 2014
    ..applicant): Constitutive activation of the classical NF-?B pathway, which principally involves RelA/p65, c-Rel, and p50, has been observed in human acute myeloid leukemia (AML) where constitutive NF-?B DNA-binding activity has been ..
  55. Molecular Markers of Risk, Phenotype, and Outcomes in ARDS
    Ednan K Bajwa; Fiscal Year: 2012
    ..Identifying patients at highest risk of developing ARDS or having adverse outcomes is critical to improving understanding of this disease and developing effective treatments. ..
  56. William G Helferich; Fiscal Year: 2015
    ..and cellular findings will also be relevant in guiding and interpreting the work in other projects in this P50 program...
  57. David N Herndon; Fiscal Year: 2016
    ..The uniqueness and innovation of this P50 Burn Center project is that for the first time, the fundamental mechanisms of the burn-induced stress phenotype and ..
  58. Center for Neuroregulation in Alcohol Dependence (CeNiAD)
    Andrew J Saxon; Fiscal Year: 2010
    ..opportunities, intellectual milieu and planning process to justify an application for a future new Specialized P50 Alcohol Research Center...
  59. The Ontogeny of Social Visual Engagement in Infants at Risk for Autism
    Warren Jones; Fiscal Year: 2012
    ..and technological advancements resulting from our continuing studies of young children with ASD (Project 1, P50 HD055726)...
  60. Danielle E Ramo; Fiscal Year: 2016
    ..The UCSF Department of Psychiatry and the NIDA-funded San Francisco Treatment Research Center (P50 DA009253) provide an exceptional research environment...
  61. Emmanuelle Passegue; Fiscal Year: 2015
    ..e., Faslpr/lpr, hematopoietic-specific Caspase-8cKO, p50-/- mice) to dissect the regulation and functional outcome of DR activation in HSCs and GMPs...
  62. Steven H Green; Fiscal Year: 2014
    ..Physiology, and Communication Sciences and Disorders, with 15 auditory-related R01s, nine funded by NIDCD, a P50, two T32s, and other grants, for a total current year direct cost >$9M...
  63. NF-kappaBeta Therapy for Duchenne Muscular Dystrophy
    Denis C Guttridge; Fiscal Year: 2012
    ..Results obtained from this proposal may lead to the development of a new treatment option to improve the quality of life and/or survival of DMD patients. ..
  64. Emerging Helminthiases in China: Genetic Diversity,
    Zheng Feng; Fiscal Year: 2006
    This revised version of our TMRC P50 application, re-titled "Emerging Helminthiasis in China: Genetic Diversity, Transmission Dynamics, and the Impact of Environmental Changes", has been prepared to reflect and incorporate the ..
  65. THE USE OF ELECTROACUPUNCTURE TO MODULATE AROUSAL
    Edgar Garcia Rill; Fiscal Year: 2002
    DESCRIPTION (APPLICANT'S ABSTRACT): The vertex-recorded midlatency auditory evoked P50 potential is a measure of the output of the reticular activating system (RAS)...
  66. INDUCTION OF ACUTE PHASE PROTEIN BIOSYNTHESIS
    David Samols; Fiscal Year: 2004
    ..These findings did not reflect classic NFkappaB activity; 1) CRP expression was inhibited by over-expressed pp65 and 2) p65 was not found in EMSA complexes...
  67. Structure/function of 105-KD basement membrane protein
    Lawrence Chan; Fiscal Year: 2005
    ..We now have the opportunity to discover and understand another previously unknown BMZ component, termed p105, also identified as a result of an autoimmune reaction...
  68. CHITINASES IN PARASITIC HELMINTHS
    Patricia Komuniecki; Fiscal Year: 2005
    ..However, recently we have reported a novel, developmentally regulated, family 19 glycosyl hydrolase (As-p50) from the parasitic nematode, Ascaris suum-the first documented occurrence of such an enzyme in an animal species...
  69. ATYPICAL ANTIPSYCHOTICS AND P50 GATING IN SCHIZOPHRENIA
    Lawrence Adler; Fiscal Year: 2001
    ..This can be demonstrated using a P50 auditorv evoked potential paradigm...