p38

Summary

Gene Symbol: p38
Description: mitogen-activated protein kinase 14
Alias: CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, SAPK2A, p38, p38ALPHA, mitogen-activated protein kinase 14, CSAID-binding protein, Csaids binding protein, MAP kinase 14, MAP kinase Mxi2, MAP kinase p38 alpha, MAX-interacting protein 2, cytokine suppressive anti-inflammatory drug binding protein, mitogen-activated protein kinase p38 alpha, p38 MAP kinase, p38 mitogen activated protein kinase, p38alpha Exip, stress-activated protein kinase 2A
Species: human

Top Publications

  1. ncbi Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1
    P Puigserver
    Dana Farber Cancer Institute, Department of Cell Biology, Boston, MA 02115, USA
    Mol Cell 8:971-82. 2001
  2. pmc Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3
    Sofia Edlund
    Ludwig Institute for Cancer Research, Biomedical Centre, 75124 Uppsala, Sweden
    Mol Biol Cell 14:529-44. 2003
  3. pmc Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
    D V Bulavin
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 18:6845-54. 1999
  4. ncbi Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1
    Masahito Matsumoto
    Department of Molecular Biology, Saitama Medical School, Saitama, Japan
    J Biol Chem 279:45969-79. 2004
  5. ncbi Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals
    Y Wu
    Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, People s Republic of China
    Oncogene 25:5787-800. 2006
  6. ncbi Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes
    Nastiti Wijayanti
    Institut für Klinische Immunologie und Transfusionsmedizin, Justus Liebig Universitat Giessen, Langhanstrasse 7, D 35392 Giessen, Germany
    J Biol Chem 280:21820-9. 2005
  7. doi Lack of the leukocyte-associated Ig-like receptor-1 expression in high-risk chronic lymphocytic leukaemia results in the absence of a negative signal regulating kinase activation and cell division
    A Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, Genoa, Italy
    Leukemia 22:980-8. 2008
  8. doi Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells
    Amandine Jaulmes
    Division of Angiology, Servier Research Institute, 11 rue des Moulineaux, Suresnes, France
    Thromb Res 124:439-46. 2009
  9. pmc HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1
    Appakkudal R Anand
    Department of Pathology, Ohio State University, Columbus, OH 43210, USA
    Blood 114:3588-600. 2009
  10. pmc Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt
    David Romano
    Proteomics and Signalling Networks Group, The Beatson Institute for Cancer Research, London, United Kingdom
    Cancer Res 70:1195-203. 2010

Research Grants

  1. Mitogen-activated Protein Kinases and NF-kB Activation in Vascular Smooth Muscle
    Bingbing Jiang; Fiscal Year: 2010
  2. THE STRESS-ACTIVATED PROTEIN KINASE PATHWAY
    John M Kyriakis; Fiscal Year: 2010
  3. Jin Kyung Kim; Fiscal Year: 2016
  4. Emilio B Gonzalez; Fiscal Year: 2014
  5. Anthrax Toxins Impair Phagocyte Actin-based Motility
    Frederick Southwick; Fiscal Year: 2010
  6. Estrogen receptor, p38 MAPKs and topo IIa in breast cancer
    Guan Chen; Fiscal Year: 2013
  7. Targeting Tight Junctions To Treat Mucositis
    FREDERICK GARY TOBACK; Fiscal Year: 2010
  8. Mechanisms that Regulate Neonatal Lung Heme Oxygenase in Hyperoxia
    Phyllis A Dennery; Fiscal Year: 2013
  9. The Role of Kappa Opioid Receptor-induced Activation of Astrocytes in the Reinsta
    Charles Chavkin; Fiscal Year: 2009
  10. The Role of Xanthine Oxidoreductase in Ventilator-Associated Lung Injury
    Paul M Hassoun; Fiscal Year: 2013

Detail Information

Publications319 found, 100 shown here

  1. ncbi Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1
    P Puigserver
    Dana Farber Cancer Institute, Department of Cell Biology, Boston, MA 02115, USA
    Mol Cell 8:971-82. 2001
    ..These data illustrate a direct thermogenic action of cytokines and p38 MAP kinase through the transcriptional coactivator PGC-1.
  2. pmc Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3
    Sofia Edlund
    Ludwig Institute for Cancer Research, Biomedical Centre, 75124 Uppsala, Sweden
    Mol Biol Cell 14:529-44. 2003
    ..prostate cancer PC-3U cells induced by TGF-beta1 or Smad7 overexpression is caused by a specific activation of the p38 mitogen-activated protein kinase pathway in a TGF-beta-activated kinase 1 (TAK1)- and mitogen-activated protein ..
  3. pmc Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation
    D V Bulavin
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 18:6845-54. 1999
    Components of the ras signaling pathway contribute to activation of cellular p53. In MCF-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway...
  4. ncbi Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1
    Masahito Matsumoto
    Department of Molecular Biology, Saitama Medical School, Saitama, Japan
    J Biol Chem 279:45969-79. 2004
    ..report the regulatory mechanisms of RANKL-induced cathepsin K gene expression during osteoclastogenesis in a p38 MAP kinase-dependent manner...
  5. ncbi Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals
    Y Wu
    Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, People s Republic of China
    Oncogene 25:5787-800. 2006
    ..Overexpression of GSTP1-1 inhibited TRAF2-induced activation of both JNK and p38 but not of nuclear factor-kappaB (NF-kappaB)...
  6. ncbi Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes
    Nastiti Wijayanti
    Institut für Klinische Immunologie und Transfusionsmedizin, Justus Liebig Universitat Giessen, Langhanstrasse 7, D 35392 Giessen, Germany
    J Biol Chem 280:21820-9. 2005
    ..AEBSF activated the mitogen-activated protein kinases (MAPK) JNK and p38. Inhibition of p38alpha and p38beta, but not that of JNK or p38gamma and p38delta, prevented the induction of HO-1 gene expression by ..
  7. doi Lack of the leukocyte-associated Ig-like receptor-1 expression in high-risk chronic lymphocytic leukaemia results in the absence of a negative signal regulating kinase activation and cell division
    A Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, Genoa, Italy
    Leukemia 22:980-8. 2008
    ..Constitutive activation of c-Jun aminoterminal kinase (JNK), p38 mitogen-activated protein kinase and extracellular signal-regulated kinase, has been reported in CLL...
  8. doi Nox4 mediates the expression of plasminogen activator inhibitor-1 via p38 MAPK pathway in cultured human endothelial cells
    Amandine Jaulmes
    Division of Angiology, Servier Research Institute, 11 rue des Moulineaux, Suresnes, France
    Thromb Res 124:439-46. 2009
    ..The aim of the present study was to characterize the role of NADPH oxidase and in particular Nox4 in the regulation of PAI-1 expression in cultured Human Umbilical Venous Endothelial Cells (HUVECs)...
  9. pmc HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1
    Appakkudal R Anand
    Department of Pathology, Ohio State University, Columbus, OH 43210, USA
    Blood 114:3588-600. 2009
    ..analysis of the downstream signaling mechanisms involved in gp120-induced migration revealed that Pyk2 activates p38 mitogen-activated protein kinase, which in turn activates the F-actin-binding protein, leukocyte-specific protein 1,..
  10. pmc Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt
    David Romano
    Proteomics and Signalling Networks Group, The Beatson Institute for Cancer Research, London, United Kingdom
    Cancer Res 70:1195-203. 2010
    ..kinase but enhanced binding to tumor suppressor RASSF1A, accentuating downstream c-Jun NH(2)-terminal kinase and p38 mitogen-activated protein kinase signaling and promoting apoptosis...
  11. pmc NSAID inhibition of prostate cancer cell migration is mediated by Nag-1 Induction via the p38 MAPK-p75(NTR) pathway
    Shehla Wynne
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC 20057, USA
    Mol Cancer Res 8:1656-64. 2010
    ..NSAIDs induce p75(NTR) through activation of the p38 mitogen-activated protein kinase (MAPK) pathway, with a concomitant decrease in cell survival...
  12. ncbi Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2
    Anila A Anwar
    Cardiovascular Division, GKT Schools of Biomedical Sciences and Medicine, King s College, University of London, Guy s Hospital Campus, London SE1 1UL, UK
    Free Radic Biol Med 39:227-36. 2005
    ..Inhibitors of protein kinase C (PKC) or mitogen-activated protein kinases (MAPK) p38(MAPK) and MEK or c-jun-NH2-terminal kinase (JNK) significantly attenuated induction of HO-1...
  13. pmc Human immunodeficiency virus type 1 Nef induces programmed death 1 expression through a p38 mitogen-activated protein kinase-dependent mechanism
    Karuppiah Muthumani
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Virol 82:11536-44. 2008
    ..Nef-induced PD-1 upregulation requires its proline-rich motif and the activation of the downstream kinase p38. Further, inhibition of Nef activity by p38 MAPK inhibitor effectively blocked PD-1 upregulation, suggesting that ..
  14. pmc Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope
    Jean Luc Perfettini
    Centre National Recherche Scientifique UMR8125, Institut Gustave Roussy, F 94805 Villejuif, France
    J Exp Med 201:279-89. 2005
    ..Cytoplasmic p38 mitogen-activated protein kinase (MAPK) was found to undergo an activating phosphorylation (p38T180/Y182P [p38 with ..
  15. ncbi Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes
    Abdelhamid Liacini
    Département de Médecine and Centre de Recherche du Centre Hospitalier de l Université de Montréal, Hôpital Notre Dame du CHUM, 1560 Sherbrooke Est, Montreal, Quebec, Canada H2L 4M1
    Matrix Biol 21:251-62. 2002
    ..IL-1 rapidly induced the activation of extracellular-signal regulated kinase (ERK), protein 38 (p38) and c-Jun N-terminal kinase (JNK) MAPKs in the first-passage human femoral head OA chondrocytes...
  16. ncbi IL-10 regulation by HIV-Tat in primary human monocytic cells: involvement of calmodulin/calmodulin-dependent protein kinase-activated p38 MAPK and Sp-1 and CREB-1 transcription factors
    Katrina Gee
    Department of Pathology and Laboratory Medicine, Division of Virology and Molecular Immunology, Children s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario, Canada
    J Immunol 178:798-807. 2007
    ..in the calcium signaling suggested that calmodulin and calmodulin-dependent protein kinase-II (CaMK-II)-activated p38 MAPK played a role in extracellular Tat-induced IL-10 expression in primary human monocytes...
  17. ncbi p38alpha and p38delta mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells
    M R Junttila
    Deparment of Dermatology, University of Turku, Turku, Finland
    Oncogene 26:5267-79. 2007
    ..of p38 pathway component mRNA expression in HNSCC cell lines (n=42) compared to HEKs (n=8) revealed that p38alpha and p38delta isoforms are predominantly expressed in both cell types and that MKK3 is the primary upstream ..
  18. ncbi VCAM-1 upregulation via PKCdelta-p38 kinase-linked cascade mediates the TNF-alpha-induced leukocyte adhesion and emigration in the lung airway epithelium
    Chang Hoon Woo
    School of Life Sciences and Biotechnology, Korea University, 5 1 Anam dong, Sungbuk Gu, Seoul, 136 701, Korea
    Am J Physiol Lung Cell Mol Physiol 288:L307-16. 2005
    ..In addition, TNF-alpha was shown to induce the expression of VCAM-1 in a p38 kinase-dependent manner; also, TNF-alpha-induced p38 kinase activation was blocked by inhibition of PKCdelta, ..
  19. ncbi The mitogen-activated protein kinase p38 regulates activator protein 1 by direct phosphorylation of c-Jun
    Matjaz Humar
    Center for Clinical Research, Department of Anesthesiology, University Hospital Freiburg, Breisacherstrasse 66, D 79106 Freiburg, Germany
    Int J Biochem Cell Biol 39:2278-88. 2007
    The involvement of p38 in fundamental physiological processes and the fact that deregulation often leads to disease indicates the potential impact of p38 dependent mechanisms...
  20. ncbi IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation
    Dolores M Cortez
    Department of Veterans Affairs South Texas Veterans Health Care System, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Am J Physiol Heart Circ Physiol 293:H3356-65. 2007
    ..and ELISA; transcriptional induction and transcription factor binding by EMSA, ELISA, and reporter assay; and p38 MAPK and ERK1/2 activation by protein kinase assays and Western blotting...
  21. doi GEF-H1/RhoA signalling pathway mediates lipopolysaccharide-induced intercellular adhesion molecular-1 expression in endothelial cells via activation of p38 and NF-κB
    Feng Guo
    Department of Burn and Plastic Surgery, Shanghai Jiao Tong University, School of Medicine, Rui Jin Hospital, Shanghai 230022, China
    Cytokine 57:417-28. 2012
    ..Furthermore, pretreatment with Y-27632, an inhibitor of ROCK, significantly reduced LPS-induced p38, ERK1/2 and p65 phosphorylation, indicating that ROCK acts as an upstream effector of p38 and ERK1/2 to promote LPS-..
  22. pmc Involvement of Kv1.3 and p38 MAPK signaling in HIV-1 glycoprotein 120-induced microglia neurotoxicity
    J Liu
    Neurophysiology Laboratory, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Cell Death Dis 3:e254. 2012
    ..3-siRNA abrogated gp120-associated microglia neurotoxic activity. Further investigation unraveled an involvement of p38 MAPK in gp120 enhancement of microglia K(v)1.3 expression and resultant neurotoxic activity...
  23. doi Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38, and p53 phosphorylation in human skeletal muscle
    Jonathan D Bartlett
    Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom
    J Appl Physiol (1985) 112:1135-43. 2012
    ..Furthermore, this is the first report of contraction-induced p53 phosphorylation in human skeletal muscle, thus highlighting an additional pathway by which exercise may initiate mitochondrial biogenesis...
  24. pmc p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression
    J Westermarck
    Turku Centre for Biotechnology, University of Turku, University of Turku, FIN 20520 Turku, Finland
    Mol Cell Biol 21:2373-83. 2001
    ..Specific activation of p38alpha by adenovirus-delivered constitutively active MKK3b resulted in potent inhibition of the activity of ERK1,2 and ..
  25. ncbi Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells
    Young D Jung
    Chonnam National University Research Institute of Medical Sciences, Hakdong 5, Kwangju, Korea
    Cytokine 18:206-13. 2002
    ..b>P38 mitogen-activated protein kinase (MAPK) was activated after 5min of IL-1beta treatment, whereas the extracellular ..
  26. pmc Mitogen-activated protein kinases regulate LSF occupancy at the human immunodeficiency virus type 1 promoter
    Loyda Ylisastigui
    University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Y9 206a, Dallas, TX 75390 9113, USA
    J Virol 79:5952-62. 2005
    ..In vitro, phosphorylation of LSF by Erk decreases binding to the LTR, while binding is increased by p38 phosphorylation...
  27. ncbi HIV type 1 glycoprotein 120 inhibits human B cell chemotaxis to CXC chemokine ligand (CXCL) 12, CC chemokine ligand (CCL)20, and CCL21
    Gamal Badr
    Institut National de la Sante et de la Recherche Medicale, Unité 131, Institut Paris Sud sur les Cytokines, Clamart, France
    J Immunol 175:302-10. 2005
    ..Unlike CXCL12, gp120 did not induce the activation of phospholipase Cbeta3 and PI3K downstream from CXCR4, whereas p38 MAPK activation was observed...
  28. ncbi HIV-1 glycoprotein 120 induces the MMP-9 cytopathogenic factor production that is abolished by inhibition of the p38 mitogen-activated protein kinase signaling pathway
    D Missé
    Laboratoire d Immunologie Rétrovirale et Moléculaire, the Institut de Recherche pour le Développement and the Centre National de la Recherche Scientifique, 240 Av E Jeanbrau, 34094 Montpellier, France
    Blood 98:541-7. 2001
    ..Thus, both p38 and SAPK/Jun N-terminal kinase mitogen-activated protein kinases (MAPKs) are activated on stimulation of these ..
  29. pmc Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypeptide
    Scott B Widenmaier
    Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 284:30372-82. 2009
    ..Akt, and Akt siRNA, it was demonstrated that GIP promoted beta-cell survival via Akt-dependent suppression of p38 MAPK and JNK and that combined inhibition was sufficient to explain the entire pro-survival responses to GIP during ..
  30. pmc REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells
    Dilli Ram Bhandari
    Adult Stem Cell Research, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea
    PLoS ONE 5:e10493. 2010
    ..Human mesenchymal stem cells (hMSCs) isolated from young tissues and cancer cells express REX1...
  31. pmc Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte
    Asuka Ota
    Division of Molecular Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Circ Res 106:1404-12. 2010
    b>p38 is an important stress activated protein kinase involved in gene regulation, proliferation, differentiation, and cell death regulation in heart...
  32. ncbi Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo
    K Deacon
    Department of Cell Physiology and Pharmacology, University of Leicester School of Medicine, P O Box 138, Medical Sciences Building, University Road, Leicester LE1 9HN, United Kingdom
    J Biol Chem 272:14489-96. 1997
    ..MKK3 specifically phosphorylates and activates p38, whereas MKK4 phosphorylates and activates both p38 and JNK...
  33. ncbi Interaction of p38 and Sp1 in a mechanical force-induced, beta 1 integrin-mediated transcriptional circuit that regulates the actin-binding protein filamin-A
    Mario D'Addario
    Canadian Institutes of Health Research Group in Matrix Dynamics, University of Toronto, Ontario, Canada
    J Biol Chem 277:47541-50. 2002
    ..This induction required actin filaments and selective activation of the p38 mitogen-activated protein kinase...
  34. ncbi Morphine potentiates HIV-1 gp120-induced neuronal apoptosis
    Shuxian Hu
    Division of Infectious Diseases and International Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    J Infect Dis 191:886-9. 2005
    ..mechanism whereby morphine potentiates gp120(IIIB)-induced neuronal apoptosis appears to involve activation of the p38 mitogen-activated protein kinase intracellular signaling pathway and microglial cells dispersed within the neuronal/..
  35. ncbi PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells
    Jingzhen Yuan
    Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine CURE Digestive Diseases Research Center and Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    J Cell Biochem 103:648-62. 2008
    It is widely recognized that Hsp27 is a downstream substrate of the p38 MAPK cascade whereas the role of PKD family members in mediating receptor-stimulated Hsp27 Ser-82 phosphorylation has not been evaluated...
  36. doi HIV-1 Tat protein induces TNF-alpha and IL-10 production by human macrophages: differential implication of PKC-betaII and -delta isozymes and MAP kinases ERK1/2 and p38
    Kaoutar Leghmari
    Laboratoire d Immuno Virologie des Lentivirus des Primates, Université Paul Sabatier 118, Toulouse, France
    Cell Immunol 254:46-55. 2008
    ..However, p38 MAP kinase seems to be involved only in IL-10 and not TNF-alpha production.
  37. pmc Vascular cell adhesion molecule-1 expression in human intestinal microvascular endothelial cells is regulated by PI 3-kinase/Akt/MAPK/NF-kappaB: inhibitory role of curcumin
    David G Binion
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Physiol Gastrointest Liver Physiol 297:G259-68. 2009
    ..expression in HIMEC was suppressed by Akt small-interfering RNA, curcumin, and inhibitors of NF-kappaB (SN-50), p38 MAPK (SB-203580) and PI 3-kinase/Akt (LY-294002)...
  38. doi DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1
    Jung Soon Mo
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Yongbong Dong, Buk Ku, Gwangju 500 757, Republic of Korea
    J Cell Biochem 110:229-37. 2010
    ..of DJ-1 inhibited H(2)O(2)-induced activation of ASK1 as well as the activation of downstream kinases in the p38 mitogen-activated protein kinase (MAPK) signaling cascade...
  39. ncbi Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest
    K Takenaka
    Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa Oiwake, Sakyo ku, Kyoto 606 01, Japan
    Science 280:599-602. 1998
    ..classical MAPK (also called ERK), c-Jun amino-terminal or stress-activated protein kinase (JNK or SAPK), and p38. Although MAPK is essential for meiotic processes in Xenopus oocytes and the spindle assembly checkpoint in Xenopus ..
  40. ncbi Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK
    Kazuyuki Kitatani
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:36793-802. 2006
    ..PMA treatment resulted in transient activation of mitogen-activated protein kinases (ERK1/2, JNK1/2, and p38) followed by dephosphorylation/inactivation...
  41. doi HIV-1 Tat protein induces IL-10 production by an alternative TNF-alpha-independent pathway in monocytes: role of PKC-delta and p38 MAP kinase
    Kaoutar Leghmari
    Laboratoire d Immuno Virologie, EA 3038, Université Paul Sabatier 118, route de Narbonne 4R3, 31062 Toulouse, Cedex, France
    Cell Immunol 253:45-53. 2008
    ..induce IL-10 production, we evaluated the link between Tat, TNF-alpha and IL-10 and the implication of PKC and p38 MAP kinase pathways...
  42. ncbi The Epstein-Barr virus oncoprotein latent membrane protein 1 induces expression of the chemokine IP-10: importance of mRNA half-life regulation
    Martina Vockerodt
    Zentrum Kinderheilkunde und Jugendmedizin, Abteilung Pädiatrie I, Georg August Universitat, Gottingen, Germany
    Int J Cancer 114:598-605. 2005
    ..IP-10 induction is inhibited by blockade of p38/SAPK2 with SB 202190, which results in decreased IP-10 mRNA half-life without affecting IP-10 promoter activity...
  43. ncbi Signal transducer and activator of transcription factor 1 mediates apoptosis induced by hepatitis C virus and HIV envelope proteins in hepatocytes
    Anuradha Balasubramanian
    Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, MA 02115, USA
    J Infect Dis 194:670-81. 2006
    ..Moreover, inhibitor studies indicated that Lyn kinase, p38 mitogen-activated protein kinase, and protein kinase C delta might be involved in STAT1 phosphorylation...
  44. doi Caveolin-1 acts as a tumor suppressor by down-regulating epidermal growth factor receptor-mitogen-activated protein kinase signaling pathway in pancreatic carcinoma cell lines
    Fei Han
    Department of Pathology, Fudan University, Shanghai, China
    Pancreas 38:766-74. 2009
    ..To investigate the effect of caveolin-1 (cav1) in pancreatic carcinoma panc1 cell growth in vitro and in vivo...
  45. ncbi Kiss-1 suppresses MMP-9 expression by activating p38 MAP kinase in human stomach cancer
    Kyung Hee Lee
    Department of Hematology Oncology, College of Medicine, Yeungnam University, Daegu, Korea
    Oncol Res 18:107-16. 2009
    ..Downregulation of Kiss-1 using Kiss-1 shRNA also increased in vitro cell invasion. In conclusion, Kiss-1 suppresses MMP-9 expression by activating the p38 MAP kinase signaling pathway.
  46. doi A p38(MAPK)/HIF-1 pathway initiated by UVB irradiation is required to induce Noxa and apoptosis of human keratinocytes
    Kris Nys
    Cell Death Research and Therapy Laboratory, Department of Molecular Cell Biology, Catholic University of Leuven, Leuven, Belgium
    J Invest Dermatol 130:2269-76. 2010
    ..Previously, we reported that in UVB-irradiated keratinocytes, p38(MAPK) instigates Bcl-2-associated X protein (Bax) activation and mitochondrial apoptosis...
  47. doi Nox2-based NADPH oxidase mediates HIV-1 Tat-induced up-regulation of VCAM-1/ICAM-1 and subsequent monocyte adhesion in human astrocytes
    Ha Yong Song
    Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Republic of Korea
    Free Radic Biol Med 50:576-84. 2011
    ..siRNA decreased HIV-1 Tat-induced NF-κB activation as well as activation of MAP kinases including ERK, JNK, and p38. These data indicate that Nox2-based NADPH oxidase is responsible for HIV-1 Tat-induced generation of ROS and plays ..
  48. pmc T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade
    Vinod S Ramgolam
    Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Departments of Medicine Cardiovascular Medicine and Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 5:e14450. 2010
    ..However, little is known regarding integrin-induced signaling cascades that affect mRNA catabolism. This study examines the role of the GTPases, Rac 1 and Rac 2, and their downstream effectors, in the LFA-1-induced effects on mRNA...
  49. ncbi Interleukin-8 induces the endothelial cell migration through the Rac 1/RhoA-p38MAPK pathway
    Y Lai
    Institute of Biomedical Engineering, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China
    Eur Rev Med Pharmacol Sci 16:630-8. 2012
    ..The objective of this study was to investigate the molecular mechanism of IL-8 induced endothelial cell migration in vitro...
  50. pmc Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase
    Thomais Markou
    Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
    Biochem J 365:757-63. 2002
    ..Maximal activation of MSK1 in adult cardiomyocytes temporally coincided with maximal p38 MAPK activation while activation of the extracellular-signal-regulated kinase (ERK) cascade was more rapid...
  51. ncbi p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells
    Jesang Ko
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, Korea
    Exp Mol Med 39:129-38. 2007
    ..up-regulation of CCR1 and CCR2 in 9CRA-stimulated cells were weakly blocked by the pretreatment of SB202190, a p38 MAPK inhibitor, and PD98059, an upstream ERK inhibitor...
  52. doi ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts
    Indira Prasadam
    Queensland University of Technology, Brisbane, Queensland, Australia
    Arthritis Rheum 62:1349-60. 2010
    ..The aim of this study was to investigate the in vitro effects of OA SBOs on the phenotypical changes in normal ACCs and to unveil the potential involvement of MAPK signaling pathways during this process...
  53. ncbi Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells
    Hye Jung Kang
    College of Pharmacy, Duksung Women s University, 4129 Ssangmun dong, Tobong ku, Seoul 132 714, Korea
    Int J Cancer 103:475-82. 2003
    ..In H-ras MCF10A cells, capsaicin treatment markedly activated c-Jun N-terminal protein kinase (JNK)-1 and p38 matigen-activated protein kinase (MAPK) while it deactivated extracellular signal-regulated protein kinases (ERKs)...
  54. pmc Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor
    Pallavi S Peter
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Clin Invest 117:1335-43. 2007
    We examined the role of p38alpha MAPK in mediating cardiomyopathy in mice overexpressing beta(1)-adrenergic receptor (beta(1)-AR) or beta(2)-AR by mating them with dominant-negative p38alpha (DNp38alpha) MAPK mice...
  55. pmc Involvement of connexin 43 in angiotensin II-induced migration and proliferation of saphenous vein smooth muscle cells via the MAPK-AP-1 signaling pathway
    Guanghong Jia
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA
    J Mol Cell Cardiol 44:882-90. 2008
    ..The effect of angiotensin II was blocked by siRNA of ERK 1/2, p38 MAPK and JNK, respectively. Overexpression of Cx43 markedly increased the proliferation of saphenous vein SMCs...
  56. pmc A novel protein kinase A-independent, beta-arrestin-1-dependent signaling pathway for p38 mitogen-activated protein kinase activation by beta2-adrenergic receptors
    Kaizheng Gong
    Institute of Vascular Medicine, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China
    J Biol Chem 283:29028-36. 2008
    A growing body of evidence has demonstrated that p38 mitogen-activated protein kinase (MAPK) has a crucial role in various physiological and pathological processes mediated by beta(2)-adrenergic receptors (beta(2)-ARs)...
  57. doi Toll-like receptor 4 regulates heme oxygenase-1 expression after hemorrhagic shock induced acute lung injury in mice: requirement of p38 mitogen-activated protein kinase activation
    Chang Chen
    Department of Anesthesiology, Zhongnan Hospital, Medical College of Wuhan University, Wuhan, Hubei, People s Republic of China
    Shock 31:486-92. 2009
    ..Arterial blood gases; expressions of TLR-4, heme oxygenase 1 (HO-1), and p38 mitogen-activated protein kinase (p38MAPK); myeloperoxidase activity; lung wet/dry ratios; and IL-10 levels in lung ..
  58. ncbi Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38
    Se Hyung Park
    Department of Obstetrics and Gynecology, British Columbia Women s Hospital, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    J Reprod Dev 55:23-9. 2009
    ..BPA rapidly induced activation of extracellular signal-regulated kinase (ERK) 1/2 and p38 MAPK at 15 min, but the effect of BPA (10 microM) on stimulation of cell growth was not blocked by pretreatment ..
  59. doi Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells
    Irena D Ignatova
    Depts of Nephrology and Hypertension and Clinical Research, Freiburgstrasse 15, Univ Hospital, Berne, CH 3010 Berne, Switzerland
    Am J Physiol Endocrinol Metab 296:E367-77. 2009
    ..We found that TNF-alpha acts via p38 MAPK pathway...
  60. pmc STAT3, p38 MAPK, and NF-kappaB drive unopposed monocyte-dependent fibroblast MMP-1 secretion in tuberculosis
    Cecilia M O'Kane
    Department of Infectious Diseases and Immunity, Hammersmith Campus, Imperial College London, London, United Kingdom
    Am J Respir Cell Mol Biol 43:465-74. 2010
    ..MMP-1 up-regulation and TIMP-1 down-regulation were p38 (but not extracellular signal-regulated kinase or c-Jun N-terminal kinase) mitogen-activated protein kinase-..
  61. pmc Differential induction of interleukin-10 in monocytes by HIV-1 clade B and clade C Tat proteins
    Justine K Wong
    Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:18319-25. 2010
    ..Moreover, we show that p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat-induced IL-10 production...
  62. pmc Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway
    Jennifer A Markovics
    Department of Pathology, Pulmonary Division, School of Medicine, University of California, San Francisco, California 94110, USA
    J Biol Chem 285:24695-706. 2010
    ..expression and that Sp1, Sp3, and several AP-1 transcription factors form a complex that binds to these sites in a p38-dependent manner...
  63. doi Reactive oxygen species-activated p38/ERK 1/2 MAPK signaling pathway in the Mycobacterium bovis bacillus Calmette Guérin (BCG)-induced CCL2 secretion in human monocytic cell line THP-1
    Patricia Méndez-Samperio
    Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, IPN, Mexico, D F, Mexico
    Arch Med Res 41:579-85. 2010
    ....
  64. ncbi Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
    Christopher Pargellis
    Department of Biology, Boehringer Ingelheim Pharmaceuticals, Research and Development Center, 900 Ridgebury Road, Ridgefield, Connecticut 06877, USA
    Nat Struct Biol 9:268-72. 2002
    The p38 MAP kinase plays a crucial role in regulating the production of proinflammatory cytokines, such as tumor necrosis factor and interleukin-1...
  65. ncbi MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha
    Baoxue Ge
    Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 295:1291-4. 2002
    ..Here, we report an unexpected activation mechanism for p38alpha MAPK that does not involve the prototypic kinase cascade...
  66. ncbi Role of p38 MAPK and RNA-dependent protein kinase (PKR) in hepatitis C virus core-dependent nuclear delocalization of cyclin B1
    Alessandra Spaziani
    Laboratory of Clinical Hepatology, Department of Internal Medicine, University of L Aquila, 67100 L Aquila, Italy
    J Biol Chem 281:10983-9. 2006
    ..On the other hand, the viral protein also increases the activity of the cyclin B1-CDK1 complex via the p38 MAPK and JNK pathways...
  67. ncbi Synergism of Toll-like receptor-induced interleukin-12p70 secretion by monocyte-derived dendritic cells is mediated through p38 MAPK and lowers the threshold of T-helper cell type 1 responses
    Hermann R Bohnenkamp
    Cancer Research UK, Breast Cancer Biology Group, Thomas Guy House, 3rd Floor, Guy s Hospital, London SE1 9RT, UK
    Cell Immunol 247:72-84. 2007
    ..activation of nuclear factor-kappaB (NF-kappaB) and mitogen activated protein kinases (MAPK) such as SAPK/JNK and p38 MAPK and the interferon (IFN) dependent pathway that signals via TRIF and results in the production of IFN-alpha/..
  68. pmc Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis
    Gaetane Mace
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 24:3235-46. 2005
    ..of an activated mutant of Rab5 stimulated endocytosis of MOR ligand-independently in wild-type but not in p38alpha-/- cells...
  69. ncbi A functional role for p38 MAPK in modulating mitotic transit in the absence of stress
    Hyukjin Cha
    Department of Genetics and Complex Diseases, School of Public Health, and John B Little Center for the Radiation Sciences and Environmental Health, Harvard University, Boston, Massachusetts 02115, USA
    J Biol Chem 282:22984-92. 2007
    Although p38 MAPK is known to be activated in response to various environmental stresses and to have inhibitory roles in cell proliferation and tumor progression, its role in cell cycle progression in the absence of stress is unknown in ..
  70. doi p38alpha is active in vitro and in vivo when monophosphorylated at threonine 180
    Nadav Askari
    Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel 91904
    Biochemistry 48:2497-504. 2009
    ..Here we tested this notion by producing p38alpha variants carrying a T180A or Y182F mutation or both and assessing their activity in vitro and in vivo...
  71. pmc p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses
    J Jefferson P Perry
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Mol Biol 391:1-11. 2009
    ..protein (MAP) kinase protein family has a critical role in cellular signaling events, with MAP kinase p38alpha acting in inflammatory processes and being an important drug discovery target...
  72. ncbi Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases
    S Dowd
    ICRF Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, Scotland, UK
    J Cell Sci 111:3389-99. 1998
    ..vitro and in vivo, displaying much reduced activity towards stress activated MAP kinase isoforms such as JNK-1 and p38/RK...
  73. ncbi Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1
    D N Slack
    Imperial Cancer Research Fund Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 276:16491-500. 2001
    ..that MKP-1 is able to interact selectively with the extracellular signal-regulated kinase 1/2 (ERK1/2), p38alpha, and c-Jun NH(2)-terminal kinase (JNK) MAP kinase isoforms...
  74. ncbi Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase
    D V Bulavin
    Division of Basic Science, National Cancer Intitute, National Institutes of Health, Bethesda, MD 20892, USA
    Nature 411:102-7. 2001
    ..Here we report that p38 kinase has a critical role in the initiation of a G2 delay after ultraviolet radiation...
  75. ncbi Selective hormone-dependent repression of estrogen receptor beta by a p38-activated ErbB2/ErbB3 pathway
    Véronique St-Laurent
    Ste Justine Hospital Research Center, 3175 Cote Ste Catherine, Montreal, Que, Canada H3T 1C5
    J Steroid Biochem Mol Biol 94:23-37. 2005
    ..However, as opposed to ERalpha, the p38 MAPK pathway was found to be involved in liganded ERbeta repression activity by ErbB2 signaling and in regulating ..
  76. ncbi p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
    Juan Jose Ventura
    CNIO Spanish National Cancer Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Nat Genet 39:750-8. 2007
    Stem cell function is central for the maintenance of normal tissue homeostasis. Here we show that deletion of p38alpha mitogen-activated protein (MAP) kinase in adult mice results in increased proliferation and defective differentiation ..
  77. ncbi Phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase regulate induction of Mcl-1 and survival in glucocorticoid-treated human neutrophils
    Arash S Saffar
    Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Allergy Clin Immunol 121:492-498.e10. 2008
    ..Glucocorticoids have been shown to inhibit human neutrophil apoptosis, with implications that this might help accentuate neutrophilic inflammation...
  78. pmc Interleukin-32 induces the differentiation of monocytes into macrophage-like cells
    Mihai G Netea
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 105:3515-20. 2008
    ..IL-32 is a cytokine inducing proinflammatory cytokines and chemokines via p38-MAPK and NF-kappaB...
  79. doi Role of TGF-beta1-independent changes in protein neosynthesis, p38alphaMAPK, and cdc42 in hydrogen peroxide-induced senescence-like morphogenesis
    Aline Chretien
    Research Unit on Cellular Biology, University of Namur, B 5000 Namur, Belgium
    Free Radic Biol Med 44:1732-51. 2008
    ..Rho-GTPase cdc42 was shown to be responsible for p38(MAPK) activation, in turn triggering phosphorylation of L-caldesmon and HSP27...
  80. ncbi Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 3 and p38 MAPK
    Kenrie P Y Hui
    Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China
    J Immunol 182:1088-98. 2009
    ..IRF3 knockdown and p38 kinase inhibition separately and in combination led to a substantial reduction of IFN-beta, IFN-lambda1, and MCP-1 ..
  81. ncbi The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase
    S Katz
    Department of Molecular Genetics and the Rappaport Family Institute for Research in the Medical Sciences and the B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Bat Galim, 31096, Haifa, Israel
    FEBS Lett 506:196-200. 2001
    ..Our data indicate that JDP2 is a bona fide substrate for the c-Jun N-terminal kinase. The precise role of JDP2 phosphorylation on its function is not yet known...
  82. ncbi Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation
    Nam On Ku
    Department of Medicine, and Geriatric Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA
    J Biol Chem 277:10775-82. 2002
    ..Here we show that Ser-73 is exclusively phosphorylated in vitro by p38 mitogen-activated protein kinase...
  83. ncbi Hypoxia activates beta(1)-integrin via ERK 1/2 and p38 MAP kinase in human vascular smooth muscle cells
    Florian Blaschke
    Deutsches Herzzentrum Berlin, Department of Cardiology, Augustenburger Platz 1, 13353 Berlin, Germany
    Biochem Biophys Res Commun 296:890-6. 2002
    ..of the pharmacological ERK 1/2 mitogen-activated protein kinase (MAPK) pathway inhibitor PD98059 (30 microM) or the p38 MAPK inhibitor SB203580 (1 microM)...
  84. ncbi cAMP targeting of p38 MAP kinase inhibits thrombin-induced NF-kappaB activation and ICAM-1 expression in endothelial cells
    Arshad Rahman
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York 14642, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1017-24. 2004
    ..Because p38 MAPK can induce transcriptional activity of RelA/p65 without altering the DNA binding function of NF-kappaB, we ..
  85. ncbi Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells
    Richard M Ogborne
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, CB1 9NL, UK
    Arterioscler Thromb Vasc Biol 25:2100-5. 2005
    ..This study examined the effects of ALA on HO-1 expression in human monocytic cells...
  86. pmc Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha
    Feng Hao
    Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN 37996, USA
    Biochim Biophys Acta 1771:883-92. 2007
    ..of p38 MAPK isotypes of alpha, beta, gamma and delta, we have identified that the activation of ERK2 (p42) and p38alpha, but not of ERK1 and the other isoforms of p38 MAPK, is required for LPA-induced migration...
  87. doi Identification of extracellular signal-regulated kinase 1/2 and p38 MAPK as regulators of human sperm motility and acrosome reaction and as predictors of poor spermatozoan quality
    Tal Almog
    Department of Biochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    J Biol Chem 283:14479-89. 2008
    ..Here we report that ERK1/2 and p38 MAPK are primarily localized to the tail of mature human spermatozoa...
  88. pmc Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus
    Vigdis Sørensen
    Centre for Cancer Biomedicine, Faculty Division Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Mol Cell Biol 28:4129-41. 2008
    ..translocation was inhibited after chemical inhibition of p38 MAPK or after small interfering RNA knockdown of p38alpha. Translocation was increased after stimulation of p38 MAPK with anisomycin, mannitol, or H2O2...
  89. ncbi Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms
    B Derijard
    Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605
    Science 267:682-5. 1995
    ..Two human MAP kinase kinases (MKK3 and MKK4) were cloned that phosphorylate and activate p38 MAP kinase. These MKK isoforms did not activate the ERK subgroup of MAP kinases, but MKK4 did activate JNK...
  90. pmc p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps
    Z Wu
    Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, La Jolla, California 92093 0322, USA
    Mol Cell Biol 20:3951-64. 2000
    ..by MyoD, and (iii) MyoD-dependent myogenic conversion is reduced in mouse embryonic fibroblasts derived from p38alpha(-/-) embryos...
  91. ncbi HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling
    M Del Corno
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Blood 98:2909-16. 2001
    ..protein kinase (MAPK) superfamily, c-Jun amino-terminal kinase/stress-activated protein kinase and p38 MAPK...
  92. ncbi TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1
    Baoxue Ge
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 278:2286-93. 2003
    ..We have recently found that activation of p38alpha MAPK can be carried out not only by its upstream MAPK kinases (MKKs) but also by p38alpha autophosphorylation...
  93. ncbi p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascades
    Guru Dutt Sharma
    Department of Ophthalmology and Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 2020 Gravier Street, New Orleans, LA 70112, USA
    J Biol Chem 278:21989-97. 2003
    ..keratinocyte growth factor (KGF), induced rapid and marked activation and prompt nuclear accumulation of phospho-p38 (p-p38) and -ERK1/2 (p-ERK1/2), but not of JNK (p-JNK1/2), in corneal epithelial cells...
  94. pmc p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils
    Maria Alvarado-Kristensson
    Division of Experimental Pathology, Lund University, U MAS, Entrance 78, Floor 3, SE 205 02 Malmo, Sweden
    J Exp Med 199:449-58. 2004
    ..Here, we show that p38-mitogen-activated protein kinase (MAPK) associates to caspase-8 and caspase-3 during neutrophil apoptosis and that ..
  95. pmc p38 mitogen-activated protein kinase mediates lipopolysaccharide and tumor necrosis factor alpha induction of shiga toxin 2 sensitivity in human umbilical vein endothelial cells
    Matthew K Stone
    Division of Nephrology, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Infect Immun 76:1115-21. 2008
    ..Cell viability assays indicated that the p38 mitogen-activated protein kinase (MAPK) inhibitors SB202190 and SB203580 and the general protein synthesis ..
  96. doi Tumor necrosis factor-alpha regulates inflammatory and mesenchymal responses via mitogen-activated protein kinase kinase, p38, and nuclear factor kappaB in human endometriotic epithelial cells
    Eric M Grund
    EMD Serono Research Institute, One Technology Place, Rockland, MA 02190, USA
    Mol Pharmacol 73:1394-404. 2008
    ..nuclear factor kappaB, extracellular signal-regulated kinase > mitogen-activated protein kinase kinase (MEK), p38, and phosphatidylinositol 3-kinase (PI3K) > Akt1/2...
  97. pmc p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms
    Jinny Kwong
    Department of Molecular Biology and Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla, California 91037, USA
    J Biol Chem 284:11237-46. 2009
    ..In the current study, we demonstrated that p38alpha and p38gamma, but not p38beta, play an essential role in oncogenic ras-induced senescence...
  98. pmc Activation of p38 MAPK is required in monocytic and neuronal cells for HIV glycoprotein 120-induced neurotoxicity
    Kathryn E Medders
    Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Immunol 185:4883-95. 2010
    ..cerebrocortical cell cultures from rodents containing microglia, astrocytes, and neurons that overall inhibition of p38 MAPK signaling abrogated the neurotoxic effect of HIV-1 gp120...
  99. ncbi Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
    J Raingeaud
    Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605, USA
    J Biol Chem 270:7420-6. 1995
    ..Immunofluorescence microscopy demonstrated that p38 MAP kinase is present in both the nucleus and cytoplasm of activated cells...
  100. pmc MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
    J Raingeaud
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01605 USA
    Mol Cell Biol 16:1247-55. 1996
    ..The detection of p38 MAP kinase in the nucleus of activated cells suggests that p38 MAP kinase can mediate signaling to the nucleus...
  101. ncbi Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
    J Han
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 386:296-9. 1997
    ..In mammalian cells the MAPK p38 is thought to play an important role in the regulation of cellular responses during infection through its effects ..

Research Grants81

  1. Mitogen-activated Protein Kinases and NF-kB Activation in Vascular Smooth Muscle
    Bingbing Jiang; Fiscal Year: 2010
    ..A major hypothesis is that extracellular signal-regulated kinase (ERK) and p38 MAPK signaling pathways inversely regulate the duration and amplitude of NF-:B activation induced by cytokines, ..
  2. THE STRESS-ACTIVATED PROTEIN KINASE PATHWAY
    John M Kyriakis; Fiscal Year: 2010
    ..mixed-lineage kinases (MLKs)-2 and -3), is required for activation of the Jun-N-terminal kinase (JNK) and p38 MAPK groups by a clinically relevant subset of pathogen-associated molecular patterns (PAMPs-molecular moieties, ..
  3. Jin Kyung Kim; Fiscal Year: 2016
    ..We hypothesize that estrogen signals to several important regulators of cell fate in ischemic stress - cardiac p38 mitogen-activated protein kinases (p38 MAPKs) and p53, a well-known mediator of apoptosis - to protect the ..
  4. Emilio B Gonzalez; Fiscal Year: 2014
    ..receptor associated protein (RAP) affect aPL-mediated upregulation of TF, ICAM-1, cytokines and p38 mitogen activated protein kinase (p38 MAPK) phosphorylation in EC and activation of monocytes and platelets...
  5. Anthrax Toxins Impair Phagocyte Actin-based Motility
    Frederick Southwick; Fiscal Year: 2010
    ..signaling using PH-GFP constructs, examine Rac signaling using a GFP- probe that binds active Rac, and investigate p38 MAPK signaling using specific antibodies and inhibitors. C...
  6. Estrogen receptor, p38 MAPKs and topo IIa in breast cancer
    Guan Chen; Fiscal Year: 2013
    ..b>p38 MAPKs consist of 1, 2, 3, and 4 proteins that are major kinase cascades to determine cellular response to upstream ..
  7. Targeting Tight Junctions To Treat Mucositis
    FREDERICK GARY TOBACK; Fiscal Year: 2010
    ..AMP peptide increased accumulation of TJ proteins (occludin, ZO-1), and stimulated the phosphorylation of p38 MAP kinase and heat shock protein 25 which could stabilize actin filaments...
  8. Mechanisms that Regulate Neonatal Lung Heme Oxygenase in Hyperoxia
    Phyllis A Dennery; Fiscal Year: 2013
    ..Nonetheless, CO can activate p38 MAP kinase signaling resulting in apoptosis...
  9. The Role of Kappa Opioid Receptor-induced Activation of Astrocytes in the Reinsta
    Charles Chavkin; Fiscal Year: 2009
    ..that stress-induced dynorphin release activates kappa opioid receptors (KOR) that stimulate phosphorylation of p38 MAPK expressed by both astroglial cells and GABAergic neurons in brain...
  10. The Role of Xanthine Oxidoreductase in Ventilator-Associated Lung Injury
    Paul M Hassoun; Fiscal Year: 2013
    ..and pharmacological inhibitors to test our hypotheses that the enzyme xanthine oxidoreductase (XOR) and the p38 MAP kinase signaling pathway play crucial roles in the pathogenesis of VALI, and anticipate that the studies proposed ..
  11. Exercise Induced Biochemical and Anatomical Adaptations
    John O Holloszy; Fiscal Year: 2013
    ..Relative to this goal our aims are to test the hypotheses that activation of p38 MAPK is the next step in the pathway leading from CAMK and AMPK to increased mitochondrial biogenesis and GLUT ..
  12. Small heat shock proteins in smooth muscle plasticity
    William T Gerthoffer; Fiscal Year: 2013
    ..proposing a substantial shift in focus of the project to test the novel idea that phosphorylation of HSP27 via the p38 MAPK/MK2 pathway inhibits the function of the miRNA silencing machinery...
  13. Mercedes Rincon; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): The p38 MAP kinase (MAPK) pathway is activated in response to stress stimuli (e.g...
  14. TAMMY ANGALINE BUTTERICK; Fiscal Year: 2016
    ..OxA has been shown to activate extracellular signal-regulated kinases 1/2 (ERK1/2) and p38 mitogen activated phosphate kinase (MAPK) in various cell models...
  15. MECHANISM OF CANALICULAR BILE FORMATION AND CHOLESTASIS
    MOHAMMED SAWKAT ANWER; Fiscal Year: 2010
    ..the role of aPKCz, Rab4 and phosphorylation in Ntcp translocation and started defining the role of nPKCd, nPKCe and p38 MAPK in Mrp2 translocation...
  16. Signaling and microRNA function in neurons
    David L Turner; Fiscal Year: 2012
    ..Phosphorylation of the Ago-2 protein by the p38 MAP kinase/MAPKAP kinase 2 (MAPKAP-K2) pathway alters its subcellular localization, and p38 kinase/ MAPKAP-K2 signaling ..
  17. Mechanism of Anthrax Lethal Factor Toxicity
    Usamah S Kayyali; Fiscal Year: 2012
    ..We have shown that p38 MAP kinase activation leading to HSP27 phosphorylation by the kinase MK2 augments the endothelial permeability barrier ..
  18. Transgenic Mouse Model to Address Heterogeneity in Autism Spectrum Disorders
    RANDY DEAN BLAKELY; Fiscal Year: 2010
    ..phosphorylation, and 3) a lack of responsiveness to multiple SERT posttranslational regulatory pathways including p38 MAPK pathways activated by inflammatory cytokines...
  19. MAP Kinase Signaling in Apoptosis-Induced Ventilator-Associated Lung Injury
    Mahendra Damarla; Fiscal Year: 2013
    ..However, the downstream effectors of p38 MAP kinase involved in mediating the development and severity of VALI remain unknown...
  20. Regulation of Skeletal Muscle Regeneration
    Yi Ping Li; Fiscal Year: 2012
    ..The activation of p38 MAPK plays a critical role in chromatin remodeling and in the activation of key myogenic transcription factors and, ..
  21. SANDRA ANN REMPEL; Fiscal Year: 2015
    ..Furthermore, we found that SPARC induces migration and invasion via the activation of p38 MAPK-MAPKAPK2-HSP27 signaling pathway...
  22. Nicholas P Poolos; Fiscal Year: 2016
    ..A novel modulator of HCN channel gating, p38 mitogen- activated kinase (p38 MAPK), was characterized as well, with inhibition of p38 MAPK causing downregulation ..
  23. MOHAMMED SAWKAT ANWER; Fiscal Year: 2014
    ..the role of aPKC , Rab4 and phosphorylation in Ntcp translocation and started defining the role of nPKC , nPKC and p38 MAPK in Mrp2 translocation...
  24. Wendell G Yarbrough; Fiscal Year: 2016
    ..We have recently found and confirmed that LZAP binds the stress activated protein kinase, p38 MAPK (hereafter p38), and the wild-type p53 induced phosphatase, Wip1...
  25. The role of microglial-and neuron-specific MyD88 signaling in tauopathies
    Kiran Bhaskar; Fiscal Year: 2013
    ..induces MAPT phosphorylation in primary neurons via activating neuronal IL1-receptor (IL1-R) and p38 mitogen activated protein kinase (p38 MAPK) pathway...
  26. Michael B Yaffe; Fiscal Year: 2016
    ..the ATR-Chk1 and ATM-Chk2 pathways that are dedicated to responding solely to signals from DNA damage per se, the p38 MAPK-MK2 pathway is a much more global stress-response pathway that can also be activated by other types of ..
  27. Adherence Activated Monocyte Genes
    Gary Brewer; Fiscal Year: 2009
    ..are cultured in the presence of either a tyrosine kinase inhibitor, or a MEK kinase inhibitor, or a p38 MAP kinase inhibitor...
  28. Anthrax Lethal Toxin-Induced Heart Failure: Role of PP2A and MAP Kinases
    David E Dostal; Fiscal Year: 2013
    ..changes in left ventricular tissue suggests that cleavage of MEKs by anthrax LT causes an imbalance in ERK, JNK and p38 MAPK activity that results in PP2A activation and reduced contractile function...
  29. Epilepsy and dendritic excitability
    NICHOLAS POOLOS; Fiscal Year: 2009
    ..A novel modulator of HCN channel gating, p38 mitogen- activated kinase (p38 MAPK), was characterized as well, with inhibition of p38 MAPK causing downregulation ..
  30. Novel CB Receptors
    Nephi Stella; Fiscal Year: 2010
    ..a stable endocannabinoid analog) activate phospholipase C, increase intracellular calcium and stimulate p38 MAP kinase phosphorylation in GPR55-expressing HEK293 cells...
  31. Peiqing Sun; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): The p38 MAPK pathway was initially identified as a mediator of inflammatory and stress responses...
  32. Peiqing Sun; Fiscal Year: 2016
    ..Studies from our lab indicate that the p38 MAPK and its downstream substrate kinase PRAK play a key role in oncogenic ras-induced senescence and tumor ..
  33. Yusuf Awni Hannun; Fiscal Year: 2015
    ..to the hypothesis that the novel salvage pathway involving GBA1/ceramide/CAPP functions to regulate the activity of p38 MAPK, which in turn couples the GBA/ceramide pathway to the regulation of cytokine-induced inflammatory responses, ..
  34. NEUROMODULATION OF THE ANTIBODY RESPONSE
    Virginia M Sanders; Fiscal Year: 2012
    ..CSR), through a mechanism that appears to inactivate Hematopoetic protein tyrosine phosphatase (HePTP) and enhance p38 MAPK phosphorylation to mediate an increase in ADAM10, which cleaves membrane CD23 to a soluble form...
  35. ETHANOL AND MAP KINASE CASCADE
    SHIVENDRA SHUKLA; Fiscal Year: 2009
    ..Based on new supporting data, it is hypothesized that "ethanol modulates p38 MAPK activity leading to downstream activation of nuclear mitogen and stress activated kinase-1 (MSK-1) and ..
  36. Hypoxia-induced Endothelial Barrier Dysfunction
    Usamah Kayyali; Fiscal Year: 2009
    ..Preliminary studies have led to the hypothesis that exposure to hypoxia initiates cell signaling through the p38 MAP kinase pathway involving MK2 and HSP27 activation that leads to actin cytoskeleton and hic-5 redistribution...
  37. NGF-Dependent Sensitization of Nociceptors by Opiates
    Frank Porreca; Fiscal Year: 2012
    ..and an increase in expression of NGF in peripheral tissues;(b) increase NGF-dependent phosphorylation of p38 MAPK (pp38 MAPK) in TrkA-positive cells, (c) increase NGF-dependent and pp38 MAPK-dependent trafficking of the ..
  38. REGULATION OF SEROTONIN TRANSPORTERS
    Randy D Blakely; Fiscal Year: 2010
    ..In Specific Aim II, we examine the role of p38 mitogen associated protein kinase (MAPK) in modulating SERT intrinsic activities...
  39. Gary S Firestein; Fiscal Year: 2016
    ..have been identified, including c-Jun N-terminal kinase (JNK), extracellular regulating kinase (ERK), and p38 MAP kinase. p38 is thought to be especially relevant to rheumatoid arthritis (RA) because it is activated in RA synovium ..
  40. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..will study the time course of FAK dephosphorylation and activation of downstream signaling pathways ERK, JNK, p38 MAP kinase and NF:B, which are known to activate MMPs...
  41. Tatiana Efimova; Fiscal Year: 2014
    ..The p38 MAPK family members function in a cell type-specific and cell context-specific manner to regulate cell ..
  42. Marcus Kaul; Fiscal Year: 2016
    ..that RANTES and MIP-1? via CCR5 reduce the activity of the pro-inflammatory and stress-related p38 mitogen activated protein kinase (MAPK) and protect cerebrocortical neurons against neurotoxicity of HIV/gp120 in an Akt-dependent ..
  43. KATHERINE JULIA KELLY; Fiscal Year: 2014
    ..both systemic, particularly interleukins (interleukin)-1 and -6, and intrarenal (angiotensin II and p38 mitogen activated protein kinase) mediators regulate ICAM-1 and LOX-1 and therefore inflammation and function in the aged, diabetic ..
  44. Regulation of Bile Acid Synthesis by Nuclear Receptors in Vivo
    Gregorio Gil; Fiscal Year: 2012
    ..12-hydroxylases, by a two-step mechanism: first, bile acids suppress HNF-4 through a process mediated by the p38 MAP kinase pathway (a novel observation recently made in the P.I...
  45. Serrine S Lau; Fiscal Year: 2014
    ..Specifically, those mediators are Nrf2, Grp78, and p38 MAPK, each of which is also a key mediator of ischemia preconditioning...
  46. MOLECULAR MODELS OF IMMUNE-MEDIATED VASCULAR INJURY
    Jeffrey R Bender; Fiscal Year: 2012
    ..of T cell LFA-1-mediated HuR translocation and mRNA stabilization, focusing on the Rac downstream targets p38 MAPK, MAPK-activated protein kinase 2 (MK2) and novel, T cell-specific MK2 targets, using pharmacologic inhibitors, ..
  47. CHONDROPROTECTIVE ACTIVITY OF POMEGRANATE EXTRACT
    Tariq M Haqqi; Fiscal Year: 2010
    ..reported that PFE exert a potent inhibitory effect on IL-1[unreadable]-induced activation of MAPK sub-groups p38-MAPK and JNK, transcription factor NF-?B and the expression of MMPs by human cartilage explants and chondrocytes in ..
  48. Beta-adrenergic regulation of adipose tissue function by PKA and MAP kinases
    Sheila Collins; Fiscal Year: 2009
    ..that additional signaling cascades emanate from [unreadable]ARs in adipocytes, and these include the ERK and p38 MAP kinase pathways...
  49. Sven Eric Jordt; Fiscal Year: 2016
    ..TRP channel, through influx of calcium, activate p38 MAP kinase, a major transducer and activator of inflammation and cell death in injured tissue...
  50. Tahir Hussain; Fiscal Year: 2016
    ..Aim 1 will study the role of p38 MAP kinase and transcription factors IRF-1 and C/EBP2 in increasing AT2 receptor expression by high glucose ..
  51. Regulation of Neuronal Survival by the Rit GTPase
    DOUGLAS ALLEN ANDRES; Fiscal Year: 2012
    ..and neurotrophin-initiated signals, to activate a distinct pro-survival signaling cascade that relies upon p38 MAP kinase signaling...
  52. Lei Wei; Fiscal Year: 2015
    ..of HDAC4 control chondrocyte differentiation and are regulated by Ca2+/calmodulin kinase IV (CaMKIV), p38 MAP kinase, and microRNA-1 respectively at different zone in the growth plate...
  53. Johnathan D Tune; Fiscal Year: 2016
    ..g. cAMP, PKA, p38 MAPK) and the regulation of myocardial glucose and fatty acid transporters (e.g. GLUT4, FAT/CD36) in lean vs...
  54. MECHANISMS OF CHONDROPROTECTION BY POMEGRANATE FRUIT EXTRACT
    Tariq M Haqqi; Fiscal Year: 2011
    ..work from this laboratory has shown that PFE exert a potent inhibitory effect on IL-IB-induced activation of p38-MAPK and JNK, NF-kB and expression of matrix metalloproteinases (MMPs) by human cartilage explants and chondrocytes ..
  55. Kenneth R McLeish; Fiscal Year: 2016
    ..Specific Objective 3 will test the working hypothesis that p38 MAPK phosphorylates multiple proteins that mediate events necessary for priming, including exocytosis and Pin1 ..
  56. INFLAMMATORY RESPONSES IN THE TOXICITY OF RICIN
    Bruce Magun; Fiscal Year: 2009
    ..translation, but also the intense and extended activation of the stress-activated protein kinases such as JNK and p38 MAPK...
  57. Ronglih Liao; Fiscal Year: 2015
    ..and demonstrated that human amyloidogenic LC (AL-LC) provoke a cardiotoxic effects via activation of non-canonical p38 MAPK signaling cascade and subsequently lead to increase cellular oxidant stress, altered calcium homeostasis, ..
  58. Laura E Nagy; Fiscal Year: 2014
    ..for ethanol-induced sensitization of LPS-stimulated TNF-1 expression, focusing TLR-4-mediated activation of p38 MAPK and regulation of mRNA stability...
  59. Carol J Homko; Fiscal Year: 2014
    ..IRE-1, the proximal ER stress sensor, which is connected to activation of stress kinases (including JNK and p38 MAPK) which are known to inhibit insulin signaling and stimulate synthesis and release of proinflammatory cytokines...
  60. Ronald B Myers; Fiscal Year: 2015
    ..use both overexpression and loss of expression and a mutagenesis study to examine the effect of ARRDC3 on cAMP and p38 MAPK signaling in response to [unreadable]3-specific agonist...
  61. Salman Azhar; Fiscal Year: 2016
    ..and PBR/TSPO;b) cellular antioxidant levels, oxidative damage and antioxidant status;and c) alteration in the ASK1- p38 MAPK signaling cascade...
  62. ARUN KUMAR RISHI; Fiscal Year: 2016
    ..CFM-4 binds with CARP-1, leads to increased CARP- 1 levels, activates pro-apoptotic p38 mitogen-activated protein kinase (MAPK), caspases-9 and 3, and apoptosis...
  63. Alcohol-Induced Fatty Liver and Injury in Humanized CYP2E1 Knockin Mice.
    Arthur I Cederbaum; Fiscal Year: 2011
    ..We propose that oxidants such as peroxynitrite, activation of MAP kinases such as JNK and/or p38 MAPK, a decline in activation of NF-:B and synthesis of survival factors, and mitochondrial dysfunction are ..
  64. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  65. Regulation of airway epithelial repair
    Steven R White; Fiscal Year: 2010
    ..cytokines activate specific signaling pathways that activate the mitogen-activated protein kinases (MAPKs), such as p38 MARK and JNK, that in turn initiate early steps in the migration of airway epithelial cells to cover damaged ..
  66. Peter J Hornsby; Fiscal Year: 2014
    ..While stress resistance is complex, there are three key pathways: NF-?B, p38 MAP kinase, and cell thiol metabolism, that have been implicated in the adverse effects of oxidative stress and ..
  67. NEUROCHEMICAL MECHANISMS OF VISCERAL PAIN
    Richard J Traub; Fiscal Year: 2013
    ..in the same dorsal horn neurons, expression in glial cells, differential activation of MAPK pathways (ERK, p38 MAPK, JNK) in visceral nociceptive processing and the effect of activation of MAPK pathways on the response of the ..
  68. Fibrosis-Protease Cross-Talk Regulating Pancreatic Cancer Invasion
    Hidayatullah G Munshi; Fiscal Year: 2013
    ..Our preliminary data also indicate that MT1-MMP increases cyclin D1 expression and enhances p38 MAPK signaling to promote growth in collagen-rich microenvironment...
  69. Anna Aldovini; Fiscal Year: 2014
    ..b>p38 MAPK, which has been reported to be activated in HIV and SIV infection, is key in the pathway of induction of ISG ..
  70. Elucidating the Fas-activated inflammation-signaling complex (FISC)
    Mihail Iordanov; Fiscal Year: 2013
    ..pathways that activate the nuclear factor-kappa B (NF-kB), the stress-activated protein kinases (SAPK) JNK and p38 MAP kinase, and the epidermal growth factor receptor (EGFR)-Ras-ERK MAP kinase cascade...
  71. FRANCESCO B RAMIREZ; Fiscal Year: 2014
    ..TGFB activation (Project 2), matrix-Induced perturbations of aorta homeostasis and repair (Project 3), and improper p38 MAPK activity and unbalanced TGFB and BMP signaling in the vascular and skeletal systems, respectively (Project 4)...
  72. RACHEL HESLER; Fiscal Year: 2015
    ..TGF-? induces p38 MAPK signaling via TRAF6, and our preliminary studies indicate TGF?-p38 MAPK signaling plays an important role in ..
  73. Thomas J Slaga; Fiscal Year: 2016
    ..including new data added to this application, we have found that UA had inhibitory effects on epidermal Akt, NFkB, p38 MAPK and JNK activation induced by TPA treatment. UA also inhibited TPA-induced epidermal hyperproliferation...
  74. Transient Receptor Potential Vanilloid-1 Sensitization in Inflammation
    JARED MICHAEL SPRAGUE; Fiscal Year: 2013
    ..We will begin with compounds that are known to block important signaling molecules such as PKA, PKC, PI3K, and p38 MAPK with the objective of finding key pathways important for TRPV1 sensitization...
  75. Lisa J Wood; Fiscal Year: 2015
    ..of ZAK, a MAP3K activated by the chemotherapeutic agent, that prolongs and intensifies the activation of JNK and p38 MAPK and synergizes with NF-kB to amplify the expression of pro-IL-1b...
  76. Effectiveness of minocycline for reducing symptoms in pancreatic cancer patients
    Xin Shelley Wang; Fiscal Year: 2013
    ..system, which it accomplishes by inhibiting microglial activation and proliferation through inhibition of the p38 MAKP pathway...
  77. Transcription & Function of Adipocyte Beta3AR in Obesity
    Sheila Collins; Fiscal Year: 2006
    ..Aims proposed: (1) to characterize the signal transduction pathway linking the betaARs in adipocytes to the p38 MAP kinase; to test the hypothesis that Rac1/Cdc42 and the MLKs are activated by PKA and, in turn, directly activate MKK3/..
  78. Role of p38 MAPK in IL-4-induced IL-6 expression in vascular endothelium
    Yongwoo Lee; Fiscal Year: 2007
    ..the proposed project, we hypothesize that IL-4 may induce inflammatory pathways in vascular endothelium through the p38 MAPK-mediated up-regulation of IL-6 expression...
  79. Novel Bioactive Lipid Receptors in Growth Regulation
    Yan Xu; Fiscal Year: 2005
    ..We hypothesize that p38 MAP kinase plays a critical role in mediating the growth inhibitory effect of SPC...
  80. Macrophage Foam Cells, Cathepsins and Cholesterol Efflux
    ALAN RICHARD TALL; Fiscal Year: 2010
    ..by binding of RANK ligand to RANK (Receptor Activator of NFkB) on macrophages and requiring activation of p38 MAP kinase. In Aim1 we will further define the relationship between different endosomal cholesterol pools, induction of ..
  81. ERYTHROPOIETIN AND THE REGULATION OF ERYTHROPOIESIS
    Sanford Krantz; Fiscal Year: 2003
    ..In addition, withdrawal of EPO activates the Jun N-terminal kinases (JNKs) and p38 MAP kinase which also produce apoptosis...