p300

Summary

Gene Symbol: p300
Description: E1A binding protein p300
Alias: KAT3B, RSTS2, p300, histone acetyltransferase p300, E1A-associated protein p300, E1A-binding protein, 300kD, p300 HAT
Species: human

Top Publications

  1. pmc Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
    Weibo Luo
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 145:732-44. 2011
  2. ncbi A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
    X J Yang
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
    Nature 382:319-24. 1996
  3. ncbi Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor
    R Eckner
    Dana Farber Cancer Institute, Boston, Massachusetts 02115
    Genes Dev 8:869-84. 1994
  4. pmc Zinc-induced formation of a coactivator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP, and Sp1
    Yong Li
    Department of Biochemistry and Molecular Biology, Mail Stop 3030, University of Kansas Medical Center, 39th and Rainbow Blvd, Kansas City, KS 66160 7421, USA
    Mol Cell Biol 28:4275-84. 2008
  5. pmc Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1
    Maimon E Hubbi
    Graduate Training Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 287:6139-49. 2012
  6. pmc The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling
    Rui Chen
    Department of Medicine, Veterans Affairs North Texas Health Care System, Dallas, TX 75216, USA
    J Biol Chem 287:30800-11. 2012
  7. doi Interplay of acetyltransferase EP300 and the proteasome system in regulating heat shock transcription factor 1
    Swasti Raychaudhuri
    Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Cell 156:975-85. 2014
  8. ncbi The transcriptional coactivators p300 and CBP are histone acetyltransferases
    V V Ogryzko
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
    Cell 87:953-9. 1996
  9. pmc Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1
    H M Sheppard
    Department of Biochemistry, University of Leicester, Leicester, LE1 7RH, United Kingdom
    Mol Cell Biol 21:39-50. 2001
  10. ncbi The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism
    Yan Shan Dai
    Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 277:24390-8. 2002

Research Grants

  1. Jianghong Liu; Fiscal Year: 2014
  2. ALCOHOL, P3 TOPOGRAPHY & FAMILY HISTORY OF ALCOHOLISM
    JORGE DARUNA; Fiscal Year: 1991
  3. MELISSA LE HOA VO; Fiscal Year: 2014
  4. Paradigm and attentional manipulations to improve P300-based BCI
    Eric Sellers; Fiscal Year: 2010
  5. Tilt/Recline Adjustment by Subjects with ALS using Brain Computer Interfaces
    Jane Huggins; Fiscal Year: 2009
  6. EVENT RELATED POTENTIALS IN OLDER SCHIZOPHRENIA PATIENTS
    John Olichney; Fiscal Year: 1999
  7. EVOKED POTENTIALS: EARLY ALZHEIMERS DISEASE DETECTION
    KENNETH ERICKSON; Fiscal Year: 1993
  8. RAJESH K ANEJA; Fiscal Year: 2016
  9. Genomic approaches to inner ear hair cell regeneration
    Michael Lovett; Fiscal Year: 2010
  10. Role of histone acetyltransferases in memory storage and synaptic plasticity
    MARCEL ANDRE ESTEVEZ; Fiscal Year: 2012

Detail Information

Publications375 found, 100 shown here

  1. pmc Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
    Weibo Luo
    Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 145:732-44. 2011
    ..directly with the HIF-1α subunit and promotes transactivation of HIF-1 target genes by enhancing HIF-1 binding and p300 recruitment to hypoxia response elements, whereas PKM1 fails to regulate HIF-1 activity...
  2. ncbi A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
    X J Yang
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
    Nature 382:319-24. 1996
    The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to the products of the p300/CBP and retinoblastoma gene families...
  3. ncbi Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor
    R Eckner
    Dana Farber Cancer Institute, Boston, Massachusetts 02115
    Genes Dev 8:869-84. 1994
    ..Among these are the retinoblastoma protein, p107, p130, and p300. We have isolated a cDNA encoding full-length human p300 and mapped the chromosomal location of the gene to ..
  4. pmc Zinc-induced formation of a coactivator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP, and Sp1
    Yong Li
    Department of Biochemistry and Molecular Biology, Mail Stop 3030, University of Kansas Medical Center, 39th and Rainbow Blvd, Kansas City, KS 66160 7421, USA
    Mol Cell Biol 28:4275-84. 2008
    ..of the cells to zinc resulted in the rapid formation of a multiprotein complex containing MTF-1, the histone acetyltransferase p300/CBP, and the transcription factor Sp1...
  5. pmc Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1
    Maimon E Hubbi
    Graduate Training Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 287:6139-49. 2012
    ..FHL2 directly interacts with HIF-1α to repress transcriptional activity. FHL1 binds to the p300/CBP co-activators and disrupts binding with HIF-1α...
  6. pmc The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling
    Rui Chen
    Department of Medicine, Veterans Affairs North Texas Health Care System, Dallas, TX 75216, USA
    J Biol Chem 287:30800-11. 2012
    ..now demonstrate that the lysine acetyltransferases cAMP-response element-binding protein-binding protein (CBP) and p300 are required for efficient Epo induction during hypoxia...
  7. doi Interplay of acetyltransferase EP300 and the proteasome system in regulating heat shock transcription factor 1
    Swasti Raychaudhuri
    Department of Cellular Biochemistry, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Cell 156:975-85. 2014
    ..Finally, the nuclear proteasome system functions in attenuating the stress response by degrading activated HSF1 in a manner linked with the clearance of misfolded proteins. ..
  8. ncbi The transcriptional coactivators p300 and CBP are histone acetyltransferases
    V V Ogryzko
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
    Cell 87:953-9. 1996
    b>p300/CBP is a transcriptional adaptor that integrates signals from many sequence-specific activators via direct interactions. Various cellular and viral factors target p300/CBP to modulate transcription and/or cell cycle progression...
  9. pmc Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1
    H M Sheppard
    Department of Biochemistry, University of Leicester, Leicester, LE1 7RH, United Kingdom
    Mol Cell Biol 21:39-50. 2001
    ..receptor coactivator 1 (SRC1) and its homologues and the general coactivators CREB binding protein (CBP) and p300. SRC1 contains an activation domain (AD1) which functions via recruitment of CBP and and p300...
  10. ncbi The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism
    Yan Shan Dai
    Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 277:24390-8. 2002
    ..This transcriptional synergy observed between GATA4 and dHAND was associated with p300 recruitment, but not with alterations in DNA binding activity of either factor...
  11. pmc c-Myc-induced aberrant DNA synthesis and activation of DNA damage response in p300 knockdown cells
    Natesan Sankar
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 284:15193-205. 2009
    We previously showed that in quiescent cells, p300/CBP (CREB-binding protein)family coactivators repress c-myc and prevent premature induction of DNA synthesis...
  12. pmc Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1
    S Sengupta
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 1079, USA
    Oncogene 30:482-93. 2011
    ..APE1 is stably associated with the basic transcription factor RNA polymerase II (RNA pol II) and the coactivator p300 on the endogenous MDR1 promoter...
  13. ncbi Regulation of the p300 HAT domain via a novel activation loop
    Paul R Thompson
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Struct Mol Biol 11:308-15. 2004
    ..However, the molecular events that regulate p300 HAT activity are poorly understood...
  14. ncbi p300 mediates androgen-independent transactivation of the androgen receptor by interleukin 6
    Jose D Debes
    Departments of Urology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Cancer Res 62:5632-6. 2002
    ..The coactivator p300 has been shown to interact with the AR during its androgen-dependent transactivation...
  15. ncbi Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)
    Ralf Janknecht
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
    Oncogene 22:746-55. 2003
    ..Consistently, MSK1 interacts with two homologous coactivators of ER81, CBP and p300, and stimulates the transactivation domains of CBP...
  16. pmc Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300
    Jorge L Ruas
    Department of Cell and Molecular Biology, Karolinska Institutet, Von Eulers vag 3, S 171 77 Stockholm, Sweden
    J Biol Chem 285:2601-9. 2010
    ..domain of HIF-1 alpha has been shown to interact with cysteine/histidine-rich region 1 (CH1) of the coactivator CBP/p300 in a hypoxia-dependent manner...
  17. pmc p300-mediated acetylation of histone H3 lysine 56 functions in DNA damage response in mammals
    Rahul K Vempati
    Department of Biology, Institute of Life Sciences, University of Hyderabad Campus, Hyderabad 500046, India
    J Biol Chem 285:28553-64. 2010
    ..We also demonstrate that the histone acetyltransferase p300 acetylates H3K56 in vitro and in vivo, whereas hSIRT2 and hSIRT3 deacetylate H3K56ac in vivo...
  18. ncbi Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP
    J R Lundblad
    Vollum Institute, Oregon Health Sciences University, Portland 97201
    Nature 374:85-8. 1995
    ..in CREB binding and transcriptional activation are highly related to the adenoviral E1A-associated cellular protein p300 (refs 2, 3), and to two hypothetical proteins from Caenorhabditis elegans, R10E11.1 and K03H1...
  19. pmc Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling
    J J Zhang
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 93:15092-6. 1996
    ..We show here that Stat1 can directly interact with the CREB-binding protein (CBP)/p300 family of transcriptional coactivators...
  20. ncbi The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
    Haihong Zhong
    Immunobiology Section and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Cell 9:625-36. 2002
    ..Our results demonstrate that phosphorylation of p65 determines whether it associates with either CBP or HDAC-1, ensuring that only p65 entering the nucleus from cytoplasmic NF-kappa B:Ikappa B complexes can activate transcription...
  21. ncbi Six lysine residues on c-Myc are direct substrates for acetylation by p300
    Kangling Zhang
    Department of Chemistry, University of California at Riverside, Riverside, CA 92521, USA
    Biochem Biophys Res Commun 336:274-80. 2005
    ..Here, we have analyzed the acetylation of recombinant Myc:Max complexes by purified p300 HAT in vitro by using MALDI-TOF and LC-ESI-MS/MS mass spectrometry...
  22. pmc Binding site specificity and factor redundancy in activator protein-1-driven human papillomavirus chromatin-dependent transcription
    Wei Ming Wang
    Simmons Comprehensive Cancer Center, Dallas, Texas 75390, USA
    J Biol Chem 286:40974-86. 2011
    ..HPV), and each AP-1 complex is capable of activating transcription from in vitro-reconstituted HPV chromatin in a p300- and acetyl-CoA-dependent manner...
  23. pmc AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins
    Y C Peng
    Department of Dermatology, New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    J Virol 74:5872-9. 2000
    ..Mol. Cell. Biol. 17:7208-7219, 1997). We show here that AMF-1 also binds the transcriptional coactivator p300 in vitro and in vivo. E2 interacted weakly with p300...
  24. pmc Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment
    Charles E Foulds
    Huntsman Cancer Institute, 2000 Circle of Hope, University of Utah, Salt Lake City, UT 84112 5550, USA
    Mol Cell Biol 24:10954-64. 2004
    ..resulted in enhanced transactivation by preferential recruitment of the coactivators CREB binding protein (CBP) and p300. We discovered this phosphorylation-augmented interaction in an unbiased affinity chromatography screen of HeLa ..
  25. ncbi Role of Akt/protein kinase B in the activity of transcriptional coactivator p300
    J Chen
    Ottawa Health Research Institute, University of Ottawa, 725 Parkdale Avenue, Ottawa, Ontario K1Y 4E9, Canada
    Cell Mol Life Sci 61:1675-83. 2004
    ..The function of transcriptional coactivator p300 is required by many transcription factors to either activate or repress gene expression...
  26. pmc Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB
    Lin Feng Chen
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94141, USA
    EMBO J 21:6539-48. 2002
    ..We now demonstrate that the p300 and CBP acetyltransferases play a major role in the in vivo acetylation of RelA, principally targeting lysines 218, ..
  27. pmc Acetylation of Dna2 endonuclease/helicase and flap endonuclease 1 by p300 promotes DNA stability by creating long flap intermediates
    Lata Balakrishnan
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 285:4398-404. 2010
    ..Acetylation of FEN1 by p300 inhibits its endonuclease activity, impairing flap cleavage, a seemingly undesirable effect...
  28. pmc The HTLV-1 tax protein cooperates with phosphorylated CREB, TORC2 and p300 to activate CRE-dependent cyclin D1 transcription
    Y M Kim
    Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523 1870, USA
    Oncogene 29:2142-52. 2010
    ..of phosphorylated CREB (pCREB) in vitro, and together the Tax-pCREB complex recruits the cellular co-activator p300 to the promoter through this unconventional Tax-responsive element...
  29. ncbi Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300
    K Nakashima
    Department of Molecular Cell Biology, Cell Fate Modulation Research Unit, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
    Science 284:479-82. 1999
    ..The transcriptional coactivator p300 interacts physically with STAT3 at its amino terminus in a cytokine stimulation-independent manner, and with Smad1 ..
  30. pmc Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha
    Steven J Freedman
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 99:5367-72. 2002
    ..by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators...
  31. pmc Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription
    Francesco Faiola
    Department of Biochemistry, University of California Riverside, Riverside, CA 92521, USA
    Mol Cell Biol 25:10220-34. 2005
    ..Here, we report a novel functional interaction between Myc TAD and the p300 coactivator-acetyltransferase...
  32. pmc CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53
    Dingding Shi
    Department of Cancer Biology, University of Massachusetts Medical School and University of Massachusetts Memorial Cancer Center, 364 Plantation Street, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 106:16275-80. 2009
    b>p300 and CREB-binding protein (CBP) act as multifunctional regulators of p53 via acetylase and polyubiquitin ligase (E4) activities...
  33. ncbi Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo
    Maria Fousteri
    Department of Toxicogenetics, Leiden University Medical Center, Einthovenweg 20, 2333 RC Leiden
    Mol Cell 23:471-82. 2006
    ..CSB fulfills a key role as a coupling factor to attract histone acetyltransferase p300, nucleotide excision repair (NER) proteins, and CSA-DDB1 E3-ubiquitin ligase complex with the COP9 ..
  34. pmc HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator
    L K Felzien
    Departments of Internal Medicine and Biological Chemistry, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109 0650, USA
    Proc Natl Acad Sci U S A 95:5281-6. 1998
    ..HIV transcription correlates with its ability to induce G2/M growth arrest, and this effect is mediated by the p300 transcriptional co-activator, which promotes cooperative interactions between the Rel A subunit of NF-kappaB and ..
  35. pmc Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300
    W Zhang
    Center for Retrovirus Research and Department of Veterinary Biosciences, The Arthur James Cancer Hospital and Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    J Virol 75:9885-95. 2001
    The highly conserved coadapters CREB binding protein (CBP) and p300 form complexes with CREB as well as other DNA binding transcription factors to modulate chromatin remodeling and thus transcription...
  36. pmc Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-kappaB pathway
    Julie Lodewick
    Institute for Microbiological Research J M Wiame and Laboratory of Microbiology, Universite Libre de Bruxelles, 1, avenue Emile Gryson, B 1070 Brussels, Belgium
    Virology 386:68-78. 2009
    ..a pool of Tax molecules acetylated on lysine residue at amino acid position 346 by the transcriptional coactivator p300. Phosphorylation of Tax on serine residues 300/301 was a prerequisite for Tax localization in the nucleus and ..
  37. pmc HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic intervention
    Michael Kogan
    Department of Neuroscience, Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA 19140, USA
    Retrovirology 8:25. 2011
    ..In view of the pivotal functions of Vpr in virus infection, replication, and persistence of infection, this protein represents an attractive target for therapeutic intervention...
  38. doi The ins and outs of HIV-1 Tat
    Solène Debaisieux
    CPBS, UMR 5236 CNRS, Universite de Montpellier, 1919 Route de Mende, 34923, Montpellier Cedex 05, France
    Traffic 13:355-63. 2012
    ..This review focuses on some of the recently identified molecular details underlying the unusual transcellular transport pathway used by Tat, such as the role of the single Trp in Tat for its membrane insertion and translocation...
  39. ncbi Repression of p15INK4b expression by Myc through association with Miz-1
    P Staller
    Institute of Molecular Biology and Tumour Research, Emil Mannkopff Strabetae 2, 35033 Marburg, Germany
    Nat Cell Biol 3:392-9. 2001
    ..Alleles of c-myc that are unable to bind to Miz-1 fail to inhibit accumulation of p15INK4b messenger RNA in primary cells and are, as a consequence, deficient in immortalization...
  40. ncbi HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators
    R Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec H3T IE2, Canada
    Oncogene 20:800-11. 2001
    ..Rather, vIRF-1 interacted with the CBP/p300 coactivators and efficiently inhibited the formation of transcriptionally competent IRF-3-CBP/p300 complexes...
  41. ncbi HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
    Michael J Gray
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcomb Boulevard, Houston, TX 77030, USA
    Oncogene 24:3110-20. 2005
    ..simultaneously to the VEGF promoter, where they form a molecular complex with the transcription coactivators CBP/p300 and Ref-1/APE...
  42. pmc Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation
    Mari Shimura
    Department of Intractable Diseases, Research Institute, National Center for Global Health and Medicine, Shinjuku, Tokyo 162 8655, Japan
    J Cell Biol 194:721-35. 2011
    ..Notably, Vpr stimulated the acetylation of histone H3, whereas p300 RNAi attenuated the Vpr-induced displacement of HP1-α and PCS...
  43. ncbi Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain
    Shiraz Mujtaba
    Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Mol Cell 9:575-86. 2002
    ..activity is dependent on lysine acetylation and its association with nuclear histone acetyltransferases p300/CBP (CREB binding protein) and p300/CBP-associated factor (PCAF)...
  44. ncbi Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription
    Marc Tini
    Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell 9:265-77. 2002
    ..We report that TDG associates with transcriptional coactivators CBP and p300 and that the resulting complexes are competent for both the excision step of repair and histone acetylation...
  45. pmc Posttranslational modifications of HIV-1 integrase by various cellular proteins during viral replication
    Yingfeng Zheng
    Laboratory of Molecular Human Retrovirology, Department of Medical Microbiology, University of Manitoba, 508 730 William Avenue, Winnipeg R3E 0W3, Canada
    Viruses 5:1787-801. 2013
    ..A number of host cellular proteins, including Lens Epithelium-derived Growth factor (LEDGF/p75), p300 and Ku70 have been shown to interact with IN and be involved in the PTM process of IN, either facilitating or ..
  46. doi Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1
    Paul O Hassa
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Mol Biol 377:668-78. 2008
    ..and human immunodeficiency virus 1 long terminal repeat promoters in concert with the transcriptional coactivators p300/CREB binding protein, CARM1, and poly(ADP-ribose) polymerase 1...
  47. doi Mapping acetylation sites in E2A identifies a conserved lysine residue in activation domain 1 that promotes CBP/p300 recruitment and transcriptional activation
    Brandy D Hyndman
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada
    Biochim Biophys Acta 1819:375-81. 2012
    ..E2A proteins can interact directly with the transcriptional co-activators and lysine acetyltranferases (KATs) CBP, p300 and PCAF to induce target gene transcription...
  48. ncbi p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter
    G Jayaraman
    Lurie Cancer Center and Microbiology and Immunology Department, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 274:17342-52. 1999
    In this paper we show that transcription factors Ets-1 and Ets-2 recruit transcription adapter proteins p300 and CBP (cAMP-responsive element-binding protein) during the transcriptional activation of the human stromelysin promoter, which ..
  49. ncbi Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation
    Katrin Kaehlcke
    Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    Mol Cell 12:167-76. 2003
    The HIV transcriptional activator Tat is acetylated by p300 at a single lysine residue in the TAR RNA binding domain. We have generated monoclonal and polyclonal antibodies specific for the acetylated form of Tat (AcTat)...
  50. ncbi Stat3 dimerization regulated by reversible acetylation of a single lysine residue
    Zheng Long Yuan
    Department of Surgery, Brown University Medical School Rhode Island Hospital, Providence, RI 02903, USA
    Science 307:269-73. 2005
    ..b>Histone acetyltransferase p300-mediated Stat3 acetylation on Lys685 was reversible by type I histone deacetylase (HDAC)...
  51. ncbi Thyroid transcription factor 1 rescues PAX8/p300 synergism impaired by a natural PAX8 paired domain mutation with dominant negative activity
    Helmut Grasberger
    The University of Chicago, MC3090, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Mol Endocrinol 19:1779-91. 2005
    ..we found that in nonthyroid cells, the acetylation-independent synergism with the general transcriptional adaptor p300 is completely abrogated, suggesting that PAX8-S48F may be unable to efficiently recruit p300...
  52. pmc Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1alpha C-terminal activation domain
    Stefan Kaluz
    Department of Microbiology and Molecular Genetics, Medical Science I B210, University of California at Irvine, College of Medicine, Irvine, CA 92697 4025, USA
    Mol Cell Biol 26:5895-907. 2006
    ..PI specifically inhibited the HIF-1 alpha CAD despite activating the HIF-1 alpha coactivator p300 and another p300 cysteine/histidine-rich domain 1-dependent transcription factor, STAT-2...
  53. pmc A rearranged EP300 gene in the human B-cell lymphoma cell line RC-K8 encodes a disabled transcriptional co-activator that contributes to cell growth and oncogenicity
    Michael R Garbati
    Department of Biology, Boston University, Boston, MA 02215, USA
    Cancer Lett 302:76-83. 2011
    ..RC-K8 has an altered EP300 locus that encodes a C-terminally truncated histone acetyltransferase (HAT) protein (p300ΔC)...
  54. pmc p300-Dependent ATF5 acetylation is essential for Egr-1 gene activation and cell proliferation and survival
    David X Liu
    Departments of Neural and Behavioural Sciences, Penn State University College of Medicine, Hershey, PA 17033, USA
    Mol Cell Biol 31:3906-16. 2011
    ..We demonstrate here that ATF5 interacts with the transcriptional coactivator p300, which acetylates ATF5 at lysine-29 (K29), which in turn enhances the interaction between ATF5 and p300 and binding ..
  55. pmc The biphasic redox sensing of SENP3 accounts for the HIF-1 transcriptional activity shift by oxidative stress
    Ying Wang
    Department of Biochemistry and Molecular Cell Biology, Key Laboratory of the Shanghai Science and Technology Commission for Cancer Microenvironment and Inflammation, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, China
    Acta Pharmacol Sin 33:953-63. 2012
    ..To investigate the mechanisms underlying the biphasic redox regulation of hypoxia-inducible factor-1 (HIF-1) transcriptional activity under different levels of oxidative stress caused by reactive oxidative species (ROS)...
  56. doi Menadione and ethacrynic acid inhibit the hypoxia-inducible factor (HIF) pathway by disrupting HIF-1α interaction with p300
    Yu Ran Na
    Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14 gil 5, Seongbuk gu, Seoul 136 791, Republic of Korea
    Biochem Biophys Res Commun 434:879-84. 2013
    ..factor (HIF)-1α that elicits transcriptional activity through recruitment of the CREB binding protein (CBP)/p300 coactivator...
  57. doi Transcriptional upregulation of HIF-1α by NF-κB/p65 and its associations with β-catenin/p300 complexes in endometrial carcinoma cells
    Tsutomu Yoshida
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Japan
    Lab Invest 93:1184-93. 2013
    ..In addition, HIF-1α was indirectly associated with nuclear β-catenin through interactions with p300, leading to slight enhancement of both HIF-1α- and β-catenin-mediated transcriptional activity...
  58. pmc Human Kruppel-related 3 (HKR3) is a novel transcription activator of alternate reading frame (ARF) gene
    Jae Hyeon Yoon
    From the Department of Biochemistry and Molecular Biology, Brain Korea 21 PLUS Project for Medical Science, Severance Biomedical Science Institute, Yonsei University School of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul 120 752, Korea
    J Biol Chem 289:4018-31. 2014
    ..HKR3 interacted with the co-activator p300 to activate ARF transcription, which increased the acetylation of histones H3 and H4 within the proximal promoter...
  59. doi Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1
    Hyun Jin Kang
    Authors Affiliations College of Pharmacy and Bio MAX institute, Research Institute of Pharmaceutical Sciences and College of Veterinary Medicine, BK21 Plus Program for Veterinary Science, Seoul National University, Seoul, Korea
    Cancer Res 74:1484-94. 2014
    ....
  60. pmc CBP-mediated FOXO-1 acetylation inhibits pancreatic tumor growth by targeting SirT
    Kartick C Pramanik
    Corresponding Author Sanjay K Srivastava, Department of Biomedical Sciences, Suite 1103, Texas Tech University Health Sciences Center, 1406 Coulter Drive, Amarillo, TX 79106
    Mol Cancer Ther 13:687-98. 2014
    ..Taken together, our results suggest that capsaicin activated JNK and FOXO-1, leading to the acetylation of FOXO-1 through CBP and SirT-1. Acetylated FOXO1 induced apoptosis in pancreatic cancer cells through BIM activation...
  61. ncbi Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
    H Chen
    Howard Hughes Medical Institute, School of Medicine, University of California at San Diego, La Jolla 92037, USA
    Cell 90:569-80. 1997
    ....
  62. ncbi Regulation of activity of the transcription factor GATA-1 by acetylation
    J Boyes
    Section of Gene Function and Regulation, Chester Beatty Laboratories at The Institute of Cancer Research, London, UK
    Nature 396:594-8. 1998
    ..co-activator proteins have intrinsic histone acetyltransferase activity (for example, Gcn5p, PCAF, TAF(II)250 and p300/CBP. These acetyltransferases also modify certain transcription factors (TFIIEbeta, TFIIF, EKLF and p53)...
  63. ncbi Acetylation of novel sites in the nucleosomal binding domain of chromosomal protein HMG-14 by p300 alters its interaction with nucleosomes
    M Bergel
    Protein Section, Division of Basic Science, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 275:11514-20. 2000
    ..Here we show that the histone acetyltransferase p300 specifically acetylates HMG-14, a nonhistone structural protein that binds to nucleosomes and reduces ..
  64. ncbi The p48 subunit of the damaged-DNA binding protein DDB associates with the CBP/p300 family of histone acetyltransferase
    A Datta
    Department of Biochemistry and Molecular Biology M C 536, College of Medicine, University of Illinois at Chicago, 1819 W Polk Street, Chicago, IL 60612, USA
    Mutat Res 486:89-97. 2001
    ..Here we show that DDB associates with the CBP/p300 family of proteins, in vivo and in vitro...
  65. pmc Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation
    Vesna Rapić-Otrin
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, E1240 BST, Pittsburgh, PA 15261, USA
    Nucleic Acids Res 30:2588-98. 2002
    ..In addition, we find that the p127 subunit of UV-DDB binds in vivo to p300, a histone acetyltransferase...
  66. ncbi Role of CBP in regulating HIF-1-mediated activation of transcription
    Jorge L Ruas
    Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    J Cell Sci 118:301-11. 2005
    ....
  67. pmc Parathyroid hormone activation of matrix metalloproteinase-13 transcription requires the histone acetyltransferase activity of p300 and PCAF and p300-dependent acetylation of PCAF
    Minnkyong Lee
    Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 285:38014-22. 2010
    ..Here, we show that p300/CBP-associated factor (PCAF), in addition to p300 and Runx2, is required for PTH activation of Mmp-13 transcription...
  68. ncbi Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene
    M Pastorcic
    Department of Pharmacology and Neuroscience and Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Biol Chem 275:34938-45. 2000
    ..We also show that the coactivator p300 enhances the activation by Ets1 and Ets2 as well as the repression by p53...
  69. ncbi Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor
    N Yamamoto
    Department of Neurobiology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Biol Chem 276:45031-40. 2001
    ..of DTX1 proteins were localized in the nucleus and physically interacted with the transcriptional coactivator p300. Through its binding to p300, DTX1 inhibited transcriptional activation by the neural-specific helix-loop-helix-..
  70. pmc Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47
    Yi Qiu
    Department of Molecular Physiology, Vanderbilt University Medical Center, Nashville, Tennessee 37215, USA
    Mol Cell Biol 22:412-20. 2002
    ..II transcriptional machinery is inhibited by the adenovirus E1A protein as a result of E1A's binding to the p300 coactivator...
  71. ncbi Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism
    Carole Brendel
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre Nationale de la Recherche Scientifique INSERM Université Louis Pasteur, BP 163, 67404 Illkirch, France
    Mol Endocrinol 16:1367-77. 2002
    ..MBF-1 seems therefore to act as a bridging factor enabling interactions of nuclear receptors with the transcription machinery...
  72. ncbi The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells
    Florence Gizard
    Oncology and Molecular Endocrinology Research Center, Laval University, Quebec GIK 7P4, Canada
    J Biol Chem 277:39144-55. 2002
    ..Consistent with previous studies showing interaction between CBP/p300 and SF-1 or TReP-132, the coexpression of these three proteins results in a synergistic effect on P450scc gene ..
  73. pmc Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1
    Frederique Gay
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Genes Dev 17:717-22. 2003
    ..elegans embryogenesis. The conservation of these lysines among other LEF/TCF family members suggests that acetylation may be an important, evolutionarily conserved mechanism regulating subcellular distribution of LEF/TCF factors...
  74. ncbi Endothelin-1-dependent nuclear factor of activated T lymphocyte signaling associates with transcriptional coactivator p300 in the activation of the B cell leukemia-2 promoter in cardiac myocytes
    Teruhisa Kawamura
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Circ Res 94:1492-9. 2004
    ..A cellular target of adenovirus early region 1A (E1A) oncoprotein, p300 also activates bcl-2 transcription in cardiac myocytes and is required for their survival...
  75. doi The hepatitis E virus ORF3 protein stabilizes HIF-1alpha and enhances HIF-1-mediated transcriptional activity through p300/CBP
    Syed M Moin
    Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    Cell Microbiol 11:1409-21. 2009
    ..The HIF complex recruits the transcriptional adapter/histone acetyltransferase protein p300/CBP to target gene promoters and p300/CBP phosphorylation is required for this interaction...
  76. pmc Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells
    L Hao
    Breast Cancer Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA
    Oncogene 29:201-13. 2010
    ..recruitment of Notch-CSL-MAML1 transcriptional complexes (NTC) and ERalpha, which promotes the recruitment of p300. CSL binding elements frequently occur in close proximity to estrogen-responsive elements (EREs) in the human and ..
  77. pmc Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner
    Derek Strassheim
    Pediatric Critical CareMedicine, University of Colorado Denver, Research Complex II, Room 6490, 12700 East 19th Avenue, Aurora, CO 80045, USA
    J Immunol 183:6981-8. 2009
    ..STAT1-S727 in the transactivation domain, thereby reducing recruitment of the histone acetylase and coactivator CBP/p300 to STAT1; 2) iloprost selectively inhibited activation of JAK2 but not JAK1, both responsible for activation of ..
  78. pmc Biochemical analysis of distinct activation functions in p300 that enhance transcription initiation with chromatin templates
    W L Kraus
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0347, USA
    Mol Cell Biol 19:8123-35. 1999
    To investigate the mechanisms of transcriptional enhancement by the p300 coactivator, we analyzed wild-type and mutant versions of p300 with a chromatin transcription system in vitro...
  79. pmc Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression
    Marcela Covic
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Zurich, Switzerland
    EMBO J 24:85-96. 2005
    ..CARM1 forms a complex with p300 and NF-kappaB in vivo and interacts directly with the NF-kappaB subunit p65 in vitro...
  80. ncbi Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation
    Paul M Evans
    Department of Biochemistry and Molecular Biology, Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    J Biol Chem 282:33994-4002. 2007
    ..We found that p300, a CREB-binding protein-related protein, interacts with KLF4 both in vitro and in vivo and activates transcription...
  81. pmc An essential role for p300/CBP in the cellular response to hypoxia
    Z Arany
    Dana Farber Cancer Institute, Boston, MA, USA
    Proc Natl Acad Sci U S A 93:12969-73. 1996
    b>p300 and CBP are homologous transcription adapters targeted by the E1A oncoprotein. They participate in numerous biological processes, including cell cycle arrest, differentiation, and transcription activation...
  82. ncbi Synergistic activation of the tumor suppressor, HLJ1, by the transcription factors YY1 and activator protein 1
    Chi Chung Wang
    NTU Center for Genomic Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
    Cancer Res 67:4816-26. 2007
    ..of the tumor suppressor, HLJ1, is up-regulated via enhancer AP-1 binding to promoter YY1 and the coactivator, p300, through DNA bending and multiprotein complex formation...
  83. ncbi Synergistic activation of transcription by CBP and p53
    W Gu
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York 10021, USA
    Nature 387:819-23. 1997
    ....
  84. ncbi Insulin suppresses transactivation by CAAT/enhancer-binding proteins beta (C/EBPbeta). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPbeta
    S Guo
    University of Illinois at Chicago College of Medicine and Veterans Affairs Chicago Health Care System, Chicago, Illinois 60612, USA
    J Biol Chem 276:8516-23. 2001
    ..Studies with E1A protein indicate that interaction with p300/CBP is required for transactivation by AD II and the effect of insulin and PKB...
  85. ncbi p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain
    Irina Lassot
    Institut Cochin, Department of Maladies Infectieuses, INSERM U567, CNRS UMR8104, University Rene Descartes Paris V, Bat G Roussy, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    J Biol Chem 280:41537-45. 2005
    ..We show here that ATF4 stability is also modulated by the histone acetyltransferase p300, which induces ATF4 stabilization by inhibiting its ubiquitination...
  86. pmc Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8
    Michael R Garbati
    Department of Biology, Boston University, Boston, MA 02215, USA
    Cancer Lett 291:237-45. 2010
    ..In this report, histone acetyltransferase p300 enhanced REL-induced transactivation and interacted with REL both in vitro and in REL-transformed ..
  87. pmc Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins
    Antonio A Postigo
    Division of Molecular Oncology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    EMBO J 22:2453-62. 2003
    ..translocation of Smad proteins, which activate transcription of specific target genes by recruiting P/CAF and p300. The two members of the ZEB family of zinc finger factors (ZEB-1/deltaEF1 and ZEB-2/SIP1) regulate TGFbeta/BMP ..
  88. ncbi p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation
    M Fu
    Albert Einstein Cancer Center, Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 275:20853-60. 2000
    ..In this study we demonstrate that the AR can be modified by acetylation in vitro and in vivo. p300 and p300/cAMP-response element-binding protein acetylated the AR at a highly conserved lysine-rich motif carboxyl-..
  89. ncbi p300 coactivates the adipogenic transcription factor CCAAT/enhancer-binding protein alpha
    R L Erickson
    Department of Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0622, USA
    J Biol Chem 276:16348-55. 2001
    ..Because the transcriptional coactivator p300 participates in the signaling of many transcription factors to the basal transcriptional apparatus, we examined ..
  90. ncbi Acetylation regulates the DNA end-trimming activity of DNA polymerase beta
    Sameez Hasan
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Mol Cell 10:1213-22. 2002
    ..Polbeta colocalized in vivo and formed a complex with the transcriptional coactivator p300. p300 interacted with Polbeta through distinct domains and acetylated Polbeta in vitro...
  91. ncbi Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2
    Jose Braganca
    Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, Henry Wellcome Building of Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    J Biol Chem 278:16021-9. 2003
    The transcriptional co-activators and histone acetyltransferases p300/CREB-binding protein (CBP) interact with CITED2, a transcription factor AP-2 (TFAP2) co-activator...
  92. ncbi CBP/p300 induction is required for retinoic acid sensitivity in human mammary cells
    Eric C Dietze
    Division of Medical Oncology and Transplantation, Duke University Medical Center, Box 2628, Durham, NC 27710, USA
    Biochem Biophys Res Commun 302:841-8. 2003
    The coactivators CBP and p300 are recruited by retinoic acid receptors (RARs) during retinoid mediated transcriptional regulation...
  93. ncbi Interaction of estrogen receptor alpha with 3-methyladenine DNA glycosylase modulates transcription and DNA repair
    Varsha S Likhite
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 279:16875-82. 2004
    ..In turn, MPG dramatically stabilized the interaction of ERalpha with ERE-containing oligos, decreased p300-mediated acetylation of the receptor, and reduced transcription of simple and complex ERE-containing reporter ..
  94. pmc Interaction of human immunodeficiency virus type 1 Tat with the transcriptional coactivators p300 and CREB binding protein
    M O Hottiger
    Departments of Internal Medicine and Biological Chemistry, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0650, USA
    J Virol 72:8252-6. 1998
    ..Here we demonstrate that transcriptional activation by HIV-1 Tat involves p300 or the related cellular transcriptional coactivator CREB binding protein (CBP)...
  95. pmc Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
    S Bhattacharya
    The Dana Farber Cancer Institute and the Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 13:64-75. 1999
    Recruitment of p300/CBP by the hypoxia-inducible factor, HIF-1, is essential for the transcriptional response to hypoxia and requires an interaction between the p300/CBP CH1 region and HIF-1alpha...
  96. ncbi Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300
    S Hasan
    Institute of Veterinary Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Mol Cell 7:1221-31. 2001
    We describe a role for the transcriptional coactivator p300 in DNA metabolism. p300 formed a complex with flap endonuclease-1 (Fen1) and acetylated Fen1 in vitro...
  97. pmc p300 acts as a transcriptional coactivator for mammalian Notch-1
    F Oswald
    Department of Internal Medicine, University of Ulm, Germany
    Mol Cell Biol 21:7761-74. 2001
    ..was inhibited by E1A12S and p53, two proteins, which interfere with the function of the common coactivator p300. Protein-protein interaction assays demonstrated the association of Notch-1-IC and the CH3 region of p300...
  98. pmc Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities
    Young Ho Lee
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    Mol Cell Biol 22:3621-32. 2002
    ..a p160 coactivator, the protein methyltransferase CARM1, and any of the three protein acetyltransferases, p300, CBP, or p/CAF...
  99. pmc T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors
    Jennifer A Kennell
    Program in Cellular and Molecular Biology, Division of Endocrinology and Metabolism, University of Michigan Medical School, 1301 E Catherine Road, Ann Arbor, MI 48109 0622, USA
    Mol Cell Biol 23:5366-75. 2003
    ..The mechanism by which beta-catenin and TCF-4N coactivated C/EBPalpha appeared to involve p300, based upon synergy between these important transcriptional regulators...
  100. ncbi P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain
    Takashi Iioka
    Division of Orthopaedic Pathomechanism, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Bone Miner Res 18:1419-29. 2003
    ..We describe here that the general coactivator p300/CBP controls the transcription activity of Cart1 through acetylation of a lysine residue that is highly conserved ..
  101. ncbi Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1
    Paul O Hassa
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Biol Chem 278:45145-53. 2003
    ..PARP-1 and p300 synergistically coactivated NF-kappaB-dependent gene expression in response to TNFalpha and LPS...

Research Grants70

  1. Jianghong Liu; Fiscal Year: 2014
    ..Lead exposure is hypothesized to give rise to two related symptoms, cognitive impairment (low IQ, reduced P300 event- related potentials, poor school performance) and emotion dysregulation (low vagal tone, low arousal, and low ..
  2. ALCOHOL, P3 TOPOGRAPHY & FAMILY HISTORY OF ALCOHOLISM
    JORGE DARUNA; Fiscal Year: 1991
    ..The proposed study will focus on the P300 component of event-related potentials...
  3. MELISSA LE HOA VO; Fiscal Year: 2014
    ..neural correlates that might evolve in the course of training using electroencephalography (EEG), namely the P300 and the N2pc...
  4. Paradigm and attentional manipulations to improve P300-based BCI
    Eric Sellers; Fiscal Year: 2010
    ..The current proposal will address three factors that can significantly improve P300-based BCI performance. First, we will manipulate matrix size from the traditional 6x6 to an 8x9 matrix...
  5. Tilt/Recline Adjustment by Subjects with ALS using Brain Computer Interfaces
    Jane Huggins; Fiscal Year: 2009
    ..proposed work will address the overall research question: "How well can subjects with ALS use a BCI based on the P300 response in electroencephalogram (EEG) to operate a power wheelchair tilt/recline system in their home environments?..
  6. EVENT RELATED POTENTIALS IN OLDER SCHIZOPHRENIA PATIENTS
    John Olichney; Fiscal Year: 1999
    DESCRIPTION (Adapted from applicant's abstract): Specific Aims: To examine the P300 and N4OO Event-Related Potentials (ERPs) in a well-characterized cohort of older schizophrenia patients, with comparably aged samples of patients with ..
  7. EVOKED POTENTIALS: EARLY ALZHEIMERS DISEASE DETECTION
    KENNETH ERICKSON; Fiscal Year: 1993
    ..specific aims of the proposed study are to: 1) Replicate the investigators preliminary findings of diminished N200-P300 amplitude and prolonged P300 latency in mild AD, using a larger, carefully selected and neuropsycholigically ..
  8. RAJESH K ANEJA; Fiscal Year: 2016
    ..modulates extracellular signal-regulated kinase (ERK) 1/2-mediated histone acetyl-transferase (HAT) activity of p300 and a closely related protein, cAMP response element-binding protein (CREB)-binding protein (CBP);3) PARP-1 ..
  9. Genomic approaches to inner ear hair cell regeneration
    Michael Lovett; Fiscal Year: 2010
    ..utricle-specific enhancer elements using ChIP-Seq methods and an antibody to the enhancer-associated co-factor p300. By correlating these three sets of data we expect to gain insights into which genes, which microRNAs and which ..
  10. Role of histone acetyltransferases in memory storage and synaptic plasticity
    MARCEL ANDRE ESTEVEZ; Fiscal Year: 2012
    ..like CREB, but also transcriptional coactivators, such as the paralogous factors CREB- binding protein (CBP) and p300. CBP and p300 are potent histone acetyltransferases (HATs) that coordinately regulate gene activity in a cell type- ..
  11. Acetylation-Dependent IFN Signal Transduction
    Y Eugene Chin; Fiscal Year: 2010
    ..acetylation by recruiting tumor suppressor-like transcription cofactor CREB-binding protein (CBP) or its homologous p300. Acetylated IFNR2 can then recruit IRF9...
  12. Cannabidiol Modulation of ???-9-THC???s Psychotomimetic Effects in Healthy Humans
    Mohini Ranganathan; Fiscal Year: 2012
    ..effects (measured on a visual analog scale of mood states for anxiety and euphoria), psychophysiological effects (P300 event related potential) and endocrine effects (serum ACTH, cortisol and prolactin levels)...
  13. Carol A Tamminga; Fiscal Year: 2016
    ..We will obtain measures of neurophysiology (e.g., eye tracking, P50 gating, PPI, and P300), neurocognition (e.g., attention/vigilance, episodic and working memory), and brain structure (e.g...
  14. Matcheri S Keshavan; Fiscal Year: 2016
    ..We will obtain measures of neurophysiology (e.g., eye tracking, P50 gating, PPI, and P300), neurocognition (e.g., attention/vigilance, episodic and working memory), and brain structure (e.g...
  15. Godfrey D Pearlson; Fiscal Year: 2016
    ..We will obtain measures of neurophysiology (e.g., eye tracking, P50 gating, PPI, and P300), neurocognition (e.g., attention/vigilance, episodic and working memory), and brain structure (e.g...
  16. Bipolar &Schizophrenia Consortium for Parsing Intermediate Phenotypes
    John A Sweeney; Fiscal Year: 2010
    ..We will obtain measures of neurophysiology (e.g., eye tracking, P50 gating, PPI, and P300), neurocognition (e.g., attention/vigilance, episodic and working memory), and brain structure (e.g...
  17. Psychometric and Neurobiological Mechanisms of Impulse Control Disorders
    Lindsay Nelson; Fiscal Year: 2010
    ..Primary ERP measures of interest include: (1) variants of the P300, an index of cognitive processing known to function as an endophenotype of externalizing proneness, and (2) the ..
  18. Subbiah Pugazhenthi; Fiscal Year: 2016
    ..STAT-1 and NF-?B, the transcriptions factors that compete with CREB for the limited pool of coactivators, CBP and p300. (iii) Inflammation can direct CREB to pathways other than those needed for neuronal function...
  19. Shirley Hill; Fiscal Year: 2014
    ..A total of 1167 day long clinical evaluations, measures of environmental variation, ERP recordings to identify P300 amplitude have been performed that spans childhood, adolescence and young adulthood...
  20. Longitudinal Predictors of Alcohol Dependence in Offspring of Multiplex Families
    Shirley Y Hill; Fiscal Year: 2013
    ..Aim 4 will investigate the relationship between right OFC volume and P300 trajectories and SUD outcome...
  21. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    ..Mass spectrometry analysis of PRDM16 transcriptional complexes showed that PRDM16 associates with p300/CBP in brown adipocyteswhether this acetyltransferase complex mediates activation of PPARs remains to be tested...
  22. Min Du; Fiscal Year: 2014
    ..AMPK also phosphorylates p300, which is expected to impair its function as a co-activator, and p300 is a necessary co-activator for transcription ..
  23. Beta-cell Proliferation
    Fredric E Wondisford; Fiscal Year: 2013
    ..Phosphorylated CREB recruits the nuclear co-activators CREB binding protein (CBP), and the related protein p300, which stimulate gene transcription through histone deacetylase activity and stimulating RNA polymerase...
  24. Robert G Roeder; Fiscal Year: 2015
    ..such as RIP140) that necessitate opposing coactivator functions, histone modifying factors such as the activating p300 acetyl- and SET1/MLL methyl-transferases, and other DNA-binding regulatory factors (C/EBPs) that act ..
  25. HTS development for targeted anti-fungal small molecules
    Paul D Kaufman; Fiscal Year: 2010
    ..Rtt109 is very distantly related the mammalian p300/CBP HAT enzyme, but compounds that inhibit p300/CBP do not inhibit Rtt109...
  26. Nicola C Partridge; Fiscal Year: 2016
    ..In the nucleus, Runx2 then recruits the histone acetyl transferases (HATs), p300 and p300/CBP associated factor (PCAF)...
  27. Prevention of acute GvHD by inhibition of cdk2
    Vassiliki A Boussiotis; Fiscal Year: 2012
    ..Cdk2 directly regulates expression of genes including NF?B, Sp1, p300/CBP, and subunits of the RNA polymerase...
  28. DEVELOPMENT OF SPLIT DAMID AS AN ALTERNATIVE METHODOLOGY TO CHROMATIN IMMUNOPRECI
    Raphael Kopan; Fiscal Year: 2010
    ..health related factors (Notch, DeltaFosB, CREB, NF[unreadable]B, and Mef2) and common transcription co-activators (p300, others) to reconstitute Dam activity only at sites where transcription takes place...
  29. C/EBP, atrogin-1, and muscle wasting
    Per Olof Hasselgren; Fiscal Year: 2009
    ..the expression and activity of transcription factors and nuclear cofactors, such as the histone acetyl transferase p300, are involved in the loss of muscle mass in catabolic conditions...
  30. Role of Cited2 in Hematopoiesis
    Yu Chung Yang; Fiscal Year: 2011
    Cited2 [CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2] is one of the founding members of a new family of transcriptional modulators...
  31. Melanie H Cobb; Fiscal Year: 2014
    ..events that control insulin gene transcription by focusing on mechanisms of recruitment of the coactivator p300. These studies should provide new understanding of how amino acids regulate insulin production, stability and ..
  32. Regulation of Hepatic Gluconeogenesis by the CREB:TORC2 Pathway
    Marc R Montminy; Fiscal Year: 2010
    ..Preliminary studies indicate that TORC2 is transiently activated through P300-dependent acetylation during early fasting, when it stimulates the gluconeogenic program via an association with a ..
  33. Marc R Montminy; Fiscal Year: 2016
    ..Preliminary studies indicate that TORC2 is transiently activated through P300-dependent acetylation during early fasting, when it stimulates the gluconeogenic program via an association with a ..
  34. Cheng Ming Chiang; Fiscal Year: 2016
    ..transcription system that we have developed to define the role of cellular chromatin-modifying enzymes, including p300 and CBP histone acetyltransferases (HATs), in AP-1-dependent activation of HPV chromatin transcription...
  35. Role of aberrant organelle stress responses in alcohol-induced liver injury
    Cheng Ji; Fiscal Year: 2012
    ..XBP-1, CHOP, ATF6, ATF4, CREB, TORC3, PGC-1a), general transcription factors (Pol II, NF-Y, NFR, Sp1, TBP and p300) and epigenetic marks (methylation of H3-K4 and H3-K79 and acetylation of H3 and H4) in promoters of mitochondrial ..
  36. Role of Protein Acetylation in Ncx1 Expression
    Donald R Menick; Fiscal Year: 2012
    ..5 leading to the recruitment of p300 and upregulation of the Ncx1 promoter...
  37. Identification of a Molecular Signature for Barrier Insulators
    LAURIE ANN STEINER; Fiscal Year: 2013
    ..the USF proteins, their associated histone methyltransferases (PRMT1, PRMT4, SET7/9), and acetyltransferases (CBP, P300, PCF), as well as an active chromatin structure (H3Ac, H4Ac, H3K4me2)...
  38. REGULATION OF GROWTH FACTORS AND EMBRYOGENESIS
    ARNOLD RIZZINO; Fiscal Year: 2005
    ..mediate its effects? Recent studies argue that Sox-2 and Oct-3 can mediate their effects through the co-activators p300 and CBP (p300/CBP)...
  39. Regulation of CFTR gene expression
    Martin Walsh; Fiscal Year: 2004
    ..examine whether transcription factors ATF1 and CBF/NF-Y and the histone acetyltransferase coactivator proteins, p300/CREB-binding protein (p300/CBP) and p300/CBP-associated factor (PCAF) mediate histone acetylation of CFTR...
  40. ANDREW JESS DANNENBERG; Fiscal Year: 2015
    ..PGE2, BRCA1, histone acetylation and aromatase induction, based on our novel data implicating BRCA1, Sirt-1 and CBP/p300 in PGE2-mediated aromatase induction...
  41. Characterization of Enhancers in the Epidermal Differentiation Complex
    CRISTINA DE GUZMAN STRONG; Fiscal Year: 2012
    ..from Washington University: In Specific Aim 2B, we will also determine if these CNS EDC map to regions bound by p300 and monomethylated H3K4 enriched in enhancer sequences using chromatin immunoprecipitation (ChIP)...
  42. Hui Bin Sun; Fiscal Year: 2016
    ..Our preliminary study indicates that the transcription factor CITED2 (CREB-binding protein/p300-interacting transactivator with ED- rich tail), a cell growth regulator and potent suppressor of cel senescence, is ..
  43. Gerhard Wagner; Fiscal Year: 2016
    ..by SREBPs, demonstrating a central role for the MED15 subunit of the Mediator co-activator complex and the CBP/p300 acetyltransferases...
  44. CBP Bromodomain Antagonists Block Androgen Receptor in Prostate Cancer
    SYED S MUJTABA; Fiscal Year: 2010
    ..Resultantly, AR remains a valuable therapeutic target due to this organ specificity. Although it is known that CBP/p300 (CREB binding protein) mediated lysine acetylation of AR (ARKac) plays a vital role in AR activation and control of ..
  45. WAYNE WILLIAM HANCOCK; Fiscal Year: 2015
    ..approaches affect Treg function in vitro? Since preliminary data points to roles for the HATs, PCAF and p300, in control of Treg suppression, we will analyze the relative contribution of these HATs to regulation of Treg vs...
  46. EBNA3C and tumor supressors
    Erle S Robertson; Fiscal Year: 2010
    ..We will investigate the recruitment of acetylases including p300 and CBP by EBNA3C to determine its ability to modify p53 through acetylation and whether or not phosphorylation is ..
  47. MATTHEW THOMAS HURD; Fiscal Year: 2014
    ..e., GCN5 and p300)...
  48. Opposing and complementary roles of KLF1 and KLF2 in erythropoiesis
    Joyce A Lloyd; Fiscal Year: 2012
    ..knockout (KO) mouse models will be used to determine if KLF1 and KLF2 are required for recruitment of BRG1 and CBP/p300 chromatin remodeling complexes to the [unreadable]-globin LCR and promoters...
  49. Effect of chromatin remodelers/modifiers on HIV-1 Tat activated transcription
    Fatah Kashanchi; Fiscal Year: 2010
    ..level in HIV-1 infected cells by binding the trans-activation response region (TAR) and recruiting cdk9/cyclin T1, p300/CBP, SWI/SNF, and RNA Polymerase II. Sustained HIV-1 replication further progresses infected T cells towards AIDS...
  50. REBECCA BEER; Fiscal Year: 2016
    ..The work will be supplemented with coursework in data analysis and statistics. Ultimately, the multidisciplinary nature of my postdoctoral training will propel me into my desired career as an academic PI. ..
  51. Determination of the role of CBP and p300 mediated Wnt signaling on colonic cells
    Michael Bordonaro; Fiscal Year: 2010
    ..in the association between beta-catenin and the transcriptional coactivators CREB binding protein (CBP) and p300. Association of CBP with beta-catenin is thought to activate a set of genes linked to cell proliferation, while the ..
  52. Role of Cited2 in lens development and hyaloid vascular regression
    Yu Chung Yang; Fiscal Year: 2010
    Cited2 (CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2) is a founding member of a new family of transcriptional modulators...
  53. Histone Acetylation and Insulin Gene Expression
    Sabire Ozcan; Fiscal Year: 2010
    ..by causing hyperacetylation of histone H4 at the insulin promoter via the recruitment of the histone acetylase p300 by Pdx-1...
  54. James P Noonan; Fiscal Year: 2016
    ..conjunction with computational and experimental filters, such as extreme evolutionary constraint and recruitment of p300, to predict enhancers and mouse transgenic technologies to identify and characterize enhancers with human-specific ..
  55. Regulation of p53 Transcription by Viral Oncoproteins &Covalent Modifications
    Cheng Ming Chiang; Fiscal Year: 2012
    ..We found that both p53 and histone acetyltransferase (HAT) p300 are essential for E6-mediated repression of p21 gene transcription...
  56. Mechanisms of p53 activation in tumorsuppression
    Wei Gu; Fiscal Year: 2012
    ..In our early studies, we found that histone acetyltransferase CBP/p300 promotes p53-dependent transcription by directly acetylating lysine residues in the C-terminal region of p53...
  57. Using AKT1 and 2 and Rb1 to approach MyoD binding mechanisms genome-wide
    Sandra B Sharp; Fiscal Year: 2012
    ..MyoD binding at numerous muscle-specific genes is facilitated by phosphorylation of the histone acetyl transferase p300 by the protein kinases AKTs 1 and 2, the consequent association of p300 with MyoD, and the removal of HDAC1 from ..
  58. Charles G Mullighan; Fiscal Year: 2016
    ..the two genes encoding the KAT3 family of histone acetyltransferases, CREB-binding protein (CBP, CREBBP) and EP300 (p300). ALL is the most common childhood cancer and the focus of this proposal...
  59. Transcriptional Coactivators and Pregnancy Outcomes
    Robert M Greene; Fiscal Year: 2012
    ..Specifically, we propose that not only is proper expression of Folbp and transcriptional coactivators such as CBP, p300, Cited2, Cart1, and AP-2 requisite for CNS formation, but the integration of these molecules into a functional ..
  60. Peilin Li; Fiscal Year: 2014
    ..IRF-1 also can interact with HAT, such as p300/CBP (cAMP-responsive-element-binding factor (CREB)-binding protein) to evoke HIV transcription from the LTR in the ..
  61. ROBERTO ARIEL GOMEZ; Fiscal Year: 2016
    ..that the transcriptional effects of cAMP are mediated by the binding of CREB and histone acetyl transferases CBP/p300 to the cAMP response element (CRE) located in the enhancer region ofthe renin gene...
  62. Testing the role of chromatin in healthspan
    Nikolai A Timchenko; Fiscal Year: 2012
    ..To achieve this goal we generated a transgenic mouse that expresses the CH3 domain of the p300 (CH3p300)...
  63. Transcriptional Regulation by the HTLV-1 Tax Protein
    Jennifer K Nyborg; Fiscal Year: 2013
    ..Together, this complex recruits the cellular coactivators CBP/p300, which is a fundamental step in transcriptional activation of HTLV-1...
  64. Role of MN1-TEL and MN1 in Leukemogenesis
    Gerard C Grosveld; Fiscal Year: 2010
    ..Although we determined that MN1 can interact with the transcription coactivators p300 and RAC and stimulates transcription of the retinoic acid receptor in HeLa cells, we know little about the ..
  65. ISABELLE MICHELE LEMASSON; Fiscal Year: 2014
    ..We found that HBZ also binds directly to the cellular coactivators p300 and CBP, which is mediated through regions of the viral protein outside its bZIP domain...
  66. Role of Cited2 in Lung Development
    Yu Chung Yang; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cited2 [CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2] is one of the founding members of a new family of transcriptional activators...
  67. Role of the Acetyltransferase p300 in Cellular Responses
    Maria Avantaggiati; Fiscal Year: 2006
    ..We made the novel finding that a transcription coactivator possessing acetyltransferase activity, p300, enhances the mitotic arrest elicited by taxol...
  68. CONTROL OF P53 TUMOR SUPPRESSOR BY CBP/P300
    Tso Pang Yao; Fiscal Year: 2005
    ..application): The long-term objective of this proposal is to elucidate the function of CBP and its family member p300 in cellular growth and oncogenesis...
  69. Mechanism of HTLV-1 Tax-mediated activation of CDK6 transcription.
    ISABELLE MICHELE LEMASSON; Fiscal Year: 2010
    ..These complexes nucleate the formation of a preinitiation complex that notably includes the coactivator p300, which is recruited directly by Tax...
  70. Genetic architecture of alcohol misuse candidate endophenotypes
    Godfrey D Pearlson; Fiscal Year: 2010
    ..We will also obtain an auditory oddball P300 event related potential assessment in all subjects undergoing imaging and derive event-related oscillation (ERO) ..