p27

Summary

Gene Symbol: p27
Description: cyclin dependent kinase inhibitor 1B
Alias: CDKN4, KIP1, MEN1B, MEN4, P27KIP1, cyclin-dependent kinase inhibitor 1B, cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Species: human

Top Publications

  1. ncbi p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion
    Gustavo Baldassarre
    Oncologia Sperimentale 2, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano 33081, Italy
    Cancer Cell 7:51-63. 2005
  2. ncbi The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
    Jiyong Liang
    Department of Molecular Therapeutics, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Nat Cell Biol 9:218-24. 2007
  3. pmc Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation
    Carlos le Sage
    Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    EMBO J 26:3699-708. 2007
  4. doi MYC antagonizes the differentiation induced by imatinib in chronic myeloid leukemia cells through downregulation of p27(KIP1.)
    M T Gómez-Casares
    Servicio de Hematología and Unidad de Investigación, Hospital Universitario Dr Negrin, Las Palmas, Spain
    Oncogene 32:2239-46. 2013
  5. pmc Role of T198 modification in the regulation of p27(Kip1) protein stability and function
    Monica Schiappacassi
    Division of Experimental Oncology 2, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy
    PLoS ONE 6:e17673. 2011
  6. ncbi Germline CDKN1B/p27Kip1 mutation in multiple endocrine neoplasia
    Marianthi Georgitsi
    Department of Medical Genetics, University of Helsinki, Finland
    J Clin Endocrinol Metab 92:3321-5. 2007
  7. ncbi CDKN1A and CDKN1B polymorphisms and risk of advanced prostate carcinoma
    Adam S Kibel
    Departments of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 63:2033-6. 2003
  8. pmc Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells
    Dong Wan Seo
    Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 1500, USA
    J Biol Chem 281:3711-21. 2006
  9. ncbi Interleukin-6 induces G1 arrest through induction of p27(Kip1), a cyclin-dependent kinase inhibitor, and neuron-like morphology in LNCaP prostate tumor cells
    S Mori
    Department of Microbiology and Immunology, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, California, 90095 1747, USA
    Biochem Biophys Res Commun 257:609-14. 1999
  10. ncbi Mutational analysis of the cell cycle inhibitor Kip1/p27 in childhood leukemia
    E A Markaki
    Department of Pediatric Hematology Oncology, University of Crete, Medical School, Heraklion Crete, Greece
    Pediatr Blood Cancer 47:14-21. 2006

Detail Information

Publications294 found, 100 shown here

  1. ncbi p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion
    Gustavo Baldassarre
    Oncologia Sperimentale 2, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano 33081, Italy
    Cancer Cell 7:51-63. 2005
    ..Here, we report that cytoplasmic expression of p27(kip1) affects microtubule (MT) stability following cell adhesion on extracellular matrix (ECM) constituents...
  2. ncbi The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
    Jiyong Liang
    Department of Molecular Therapeutics, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Nat Cell Biol 9:218-24. 2007
    ..We present evidence that the cyclin-dependent kinase inhibitor p27(Kip1), is phosphorylated at Thr 198 downstream of the Peutz-Jeghers syndrome protein-AMP-activated protein kinase (LKB1-..
  3. pmc Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation
    Carlos le Sage
    Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    EMBO J 26:3699-708. 2007
    ..novel functional genetic approach and identified miR-221 and miR-222 (miR-221&222) as potent regulators of p27(Kip1), a cell cycle inhibitor and tumor suppressor...
  4. doi MYC antagonizes the differentiation induced by imatinib in chronic myeloid leukemia cells through downregulation of p27(KIP1.)
    M T Gómez-Casares
    Servicio de Hematología and Unidad de Investigación, Hospital Universitario Dr Negrin, Las Palmas, Spain
    Oncogene 32:2239-46. 2013
    ..We found that imatinib upregulated the cell cycle inhibitor p27(KIP1) (p27) in a time- and -concentration dependent manner, and that the extent of imatinib-mediated differentiation was ..
  5. pmc Role of T198 modification in the regulation of p27(Kip1) protein stability and function
    Monica Schiappacassi
    Division of Experimental Oncology 2, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy
    PLoS ONE 6:e17673. 2011
    The tumor suppressor gene p27(Kip1) plays a fundamental role in human cancer progression. Its expression and/or functions are altered in almost all the different tumor histotype analyzed so far...
  6. ncbi Germline CDKN1B/p27Kip1 mutation in multiple endocrine neoplasia
    Marianthi Georgitsi
    Department of Medical Genetics, University of Helsinki, Finland
    J Clin Endocrinol Metab 92:3321-5. 2007
    ..Recently, a germline mutation in the CDKN1B gene, encoding p27(Kip1), was reported in one suspected MEN1 family with two acromegalic patients.
  7. ncbi CDKN1A and CDKN1B polymorphisms and risk of advanced prostate carcinoma
    Adam S Kibel
    Departments of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 63:2033-6. 2003
    ..nucleotide polymorphic variants in the 3'-untranslated region of CDKN1A (p21(cip1)) and in codon 109 of CDKN1B (p27(kip1)) for association with advanced prostate cancer in a European-American population...
  8. pmc Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells
    Dong Wan Seo
    Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 1500, USA
    J Biol Chem 281:3711-21. 2006
    ..G1 growth arrest in human endothelial cells through de novo synthesis of the cyclin-dependent kinase inhibitor p27Kip1. TIMP-2-mediated inhibition of Cdk4 and Cdk2 activity is associated with increased binding of p27Kip1 to these ..
  9. ncbi Interleukin-6 induces G1 arrest through induction of p27(Kip1), a cyclin-dependent kinase inhibitor, and neuron-like morphology in LNCaP prostate tumor cells
    S Mori
    Department of Microbiology and Immunology, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, California, 90095 1747, USA
    Biochem Biophys Res Commun 257:609-14. 1999
    ..levels of cyclin-dependent kinase-2 (CDK2), CDK4, and CDK6 were decreased, while accumulation of CDK inhibitor p27(Kip1) was rapidly and markedly induced...
  10. ncbi Mutational analysis of the cell cycle inhibitor Kip1/p27 in childhood leukemia
    E A Markaki
    Department of Pediatric Hematology Oncology, University of Crete, Medical School, Heraklion Crete, Greece
    Pediatr Blood Cancer 47:14-21. 2006
    ..b>Kip1/p27 is the main cyclin-dependent kinase inhibitor, which arrests cell division inhibiting G1-S transition...
  11. pmc Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer
    Inke Timmerbeul
    Department of Gastroenterology, Hepatology, and Endocrinology, Institute for Molecular Biology, Department of Hematology and Oncology, Institute for Pathology, Hannover Medical School, D 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 103:14009-14. 2006
    Decreased expression of the CDK inhibitor p27kip1 in human tumors directly correlates with increased resistance to chemotherapies, increased rates of metastasis, and an overall increased rate of patient mortality...
  12. pmc Promotion of cytoplasmic mislocalization of p27 by Helicobacter pylori in gastric cancer
    S Wen
    Department of Medicine, Division of Gastroenterology, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Oncogene 31:1771-80. 2012
    The cyclin-dependent kinase (CDK) inhibitor p27 has an important role in cell cycle regulation. Reduced expression of p27 is commonly associated with poor prognosis in many malignancies, including gastric cancer...
  13. pmc C-terminal phosphorylation controls the stability and function of p27kip1
    Uta Kossatz
    Institute for Molecular Biology, Hannover Medical School, Hannover, Germany
    EMBO J 25:5159-70. 2006
    ..Degradation of p27kip1 is known to be a central component of this process as it allows controlled activation of cdk2-associated kinase ..
  14. ncbi Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing
    M Shirane
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 274:13886-93. 1999
    The intracellular level of p27(Kip1), a cyclin-dependent kinase (CDK) inhibitory protein, is rapidly reduced at the G1/S transition phase when the cell cycle pause ceases...
  15. pmc The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells
    Lifang Lu
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, USA
    BMC Cell Biol 3:22. 2002
    The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers...
  16. pmc Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions
    Sandra S McAllister
    Howard Hughes Medical Institute, University of California San Diego School of Medicine, La Jolla 92093 0686, USA
    Mol Cell Biol 23:216-28. 2003
    ..of HepG2 human hepatocellular carcinoma cells induces cell migration concomitant with increased levels of the p27(kip1) cyclin-cdk inhibitor...
  17. ncbi p21Cip1 and p27Kip1 induce distinct cell cycle effects and differentiation programs in myeloid leukemia cells
    Maria J Munoz-Alonso
    Grupo de Biología Molecular del Cáncer, Departamento de Biología Molecular y Unidad de Biomedicina Consejo Superior de Investigaciones Científicas, Universidad de Cantabria, 39011 Santander, Spain
    J Biol Chem 280:18120-9. 2005
    The cyclin-dependent kinase (Cdk) inhibitors p21(Cip1) and p27(Kip1) have been proposed to exert redundant functions in cell cycle progression and differentiation programs, although nonoverlapping functions have also been described...
  18. ncbi Cell cycle-dependent caspase-like activity that cleaves p27(KIP1) is the beta(1) subunit of the 20S proteasome
    Winston S Tambyrajah
    School of Life Sciences, University of Sussex, Brighton, UK
    Arch Biochem Biophys 466:186-93. 2007
    ..activity, which we termed KIPase that is implicated in the turnover of the mammalian cell cycle regulator p27(KIP1)...
  19. pmc SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells
    Gabriel Bretones
    Departamento de Biologia Molecular, Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria, Consejo Superior de Investigaciones Cientificas, SODERCAN Sociedad para el Desarrollo de Cantabria, 39011 Santander, Spain
    J Biol Chem 286:9815-25. 2011
    SKP2 is the ubiquitin ligase subunit that targets p27(KIP1) (p27) for degradation...
  20. doi Cooperative role between p21cip1/waf1 and p27kip1 in premature senescence in glandular proliferative lesions in mice
    R A Garcia-Fernandez
    Departamento de Medicina y Cirugia Animal, Facultad Veterinaria, UCM, Madrid, Spain
    Histol Histopathol 29:397-406. 2014
    ..It has also been pointed out that p21(cip1/waf1) and p27(kip1) cyclin-dependent kinase inhibitors (CKIs) play a role in cellular senescence in some tumor types...
  21. doi Human papillomavirus 16 E6/E7-immortalized human gingival keratinocytes with epithelial mesenchymal transition acquire increased expression of cIAP-1, Bclx and p27(Kip1)
    Walee Chamulitrat
    Department of Internal Medicine IV, University Heidelberg Hospital, Heidelberg, Germany
    Exp Dermatol 18:1067-9. 2009
    ..We found that EMT cells expressed significantly elevated levels of cIAP-1, Bclx and p27(kip) higher than non-EMT cells...
  22. ncbi Regulated expression of cofilin and the consequent regulation of p27(kip1) are essential for G(1) phase progression
    Cheng Han Tsai
    Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang Ming University, Taipei, Taiwan
    Cell Cycle 8:2365-74. 2009
    ..cycle proteins controlling the G(1) phase progression revealed that the cyclin-dependent kinase inhibitor (CKI) p27(kip1) was the primary molecule induced by overexpressed cofilin in a time and dose dependent manner...
  23. pmc Regulation of Skp2 levels by the Pim-1 protein kinase
    Bo Cen
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 285:29128-37. 2010
    ..to regulate cell growth is mediated, in part, by the capacity of this protein kinase to control the levels of the p27, a protein that is a critical regulator of cyclin-dependent kinases that mediate cell cycle progression...
  24. pmc Clinicopathological significance of expression of Tspan-1, Jab1 and p27 in human hepatocellular carcinoma
    Li Chen
    Department of Pathology, Affiliated Hospital, Nantong University, Nantong, China
    J Korean Med Sci 25:1438-42. 2010
    The aim of this study was to investigate the expression of Tspan-1, Jab1 and p27 in human hepatocellular carcinoma (HCC) and their clinicopathological significance...
  25. pmc Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control
    H Jakel
    Division of Medical Biochemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Oncogene 30:3502-12. 2011
    ..In this study, we describe the identification of the cyclin-dependent kinase (CDK) inhibitor p27(Kip1) as a novel JAK2 substrate. JAK2 can directly bind and phosphorylate p27(Kip1)...
  26. pmc WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) delays cellular senescence by promoting p27(Kip1) degradation in human diploid fibroblasts
    Xiaoxiao Cao
    Research Center on Aging, Department of Biochemistry and Molecular Biology, Peking University, Health Science Center, Beijing 100191, China
    J Biol Chem 286:33447-56. 2011
    ..Here, we show that the expression patterns of p27(Kip1) and WWP1 are inversely correlated during cellular senescence...
  27. doi Novel mutations in MEN1, CDKN1B and AIP genes in patients with multiple endocrine neoplasia type 1 syndrome in Spain
    Oihana Belar
    Endocrinology Research Group, Cruces Hospital, CIBERER, Barakaldo, Bizkaia, Spain
    Clin Endocrinol (Oxf) 76:719-24. 2012
    ..Not all patients with MEN1 phenotype present a defect in this gene. Thus, other genes like CDKN and AIP have been showed to be involved in MEN1-like patients...
  28. doi Early mitotic inhibitor-1, an anaphase-promoting complex/cyclosome inhibitor, can control tumor cell proliferation in hepatocellular carcinoma: correlation with Skp2 stability and degradation of p27(Kip1)
    Yunhong Zhao
    Department of Pathology, Nantong University Cancer Hospital, Medical College of Nantong University, Nantong, Jiangsu 226001, PR China
    Hum Pathol 44:365-73. 2013
    ..serum starvation, the expression of Emi1 APC/C substrates (cyclins A, B) and Skp2 was up-regulated, whereas p27(Kip1) was down-regulated...
  29. doi Polymorphisms in the p27kip-1 and prohibitin genes denote novel genes associated with melanoma risk in Brazil, a high ultraviolet index region
    Guilherme Francisco
    Experimental Oncology Laboratory, Medical Investigation Laboratory, Unit 24, Department of Radiology
    Melanoma Res 23:231-6. 2013
    ..This study was carried out to evaluate the role of polymorphisms in cell cycle genes such as TP53, p27, CDKN2A, prohibitin, and GADD153 in melanoma risk as well as their influence on known risk factors in a high UV ..
  30. ncbi Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity
    M Schreiber
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Oncogene 18:1663-76. 1999
    ..vectors were constructed to overexpress cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 under the control of the murine cytomegalovirus immediate early gene promoter...
  31. pmc Loss of cell cycle regulators p27(Kip1) and cyclin E in transitional cell carcinoma of the bladder correlates with tumor grade and patient survival
    J J Del Pizzo
    Division of Urology, Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Am J Pathol 155:1129-36. 1999
    The cyclin-dependent kinase inhibitor p27(Kip1) is a powerful molecular determinant of cell cycle progression. Loss of expression of p27(Kip1) has been shown to be predictive of disease progression in several human malignancies...
  32. ncbi The cell cycle regulator p27Kip1 interacts with MCM7, a DNA replication licensing factor, to inhibit initiation of DNA replication
    Shriram Nallamshetty
    National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 4523, 50 Center Drive, Bethesda, MD 20892, USA
    FEBS Lett 579:6529-36. 2005
    ..Here, we report a novel function for the cyclin-dependent kinase inhibitor p27Kip1 in inhibiting DNA replication through its interaction with MCM7, a DNA replication protein that is essential for ..
  33. ncbi High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers
    Mai Shimada
    Department of Biochemistry 1, Hamamatsu University School of Medicine, Higashi ku, Hamamatsu, Shizuoka, Japan
    Cancer Sci 100:866-72. 2009
    Downregulation of the cyclin-dependent kinase inhibitory protein p27 is frequently observed in various cancers due to enhancement of its degradation...
  34. ncbi Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer
    Giuseppe Viglietto
    Istituto di Endocrinologia ed Oncologia Sperimentale, CNR c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Naples, Italy
    Nat Med 8:1136-44. 2002
    The cyclin-dependent kinase inhibitor p27(kip1) is a putative tumor suppressor for human cancer. The mechanism underlying p27(kip1) deregulation in human cancer is, however, poorly understood...
  35. pmc MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1
    Tyler E Miller
    Department of Molecular and Cellular Biochemistry, College of Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 283:29897-903. 2008
    ..The protein level of the cell cycle inhibitor p27(Kip1), a known target of miR-221/222, was reduced by 50% in OHT(R) cells and by 28-50% in miR-221/222-overexpressing MCF-..
  36. ncbi Combined loss of PTEN and p27 expression is associated with tumor cell proliferation by Ki-67 and increased risk of recurrent disease in localized prostate cancer
    Ole J Halvorsen
    Department of Pathology, The Gade Institute, Haukeland University Hospital, N 5021 Bergen, Norway
    Clin Cancer Res 9:1474-9. 2003
    Recent experimental work indicates a major role for PTEN and p27 in prostate cancer...
  37. ncbi Prognostic impact of Skp2 and p27 in human breast cancer
    Frank Traub
    Institue of Pathology, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625, Hannover, Germany
    Breast Cancer Res Treat 99:185-91. 2006
    ..cycle is controlled by cyclin-dependent kinases and one of the key players is the cyclin-dependent kinase inhibitor p27. The F-box protein Skp2 is a regulator of G1-S transition and promotes specifically the ubiquitin-mediated ..
  38. pmc A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression
    Manfred Boehm
    Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 21:3390-401. 2002
    The cyclin-dependent kinase inhibitor, p27(Kip1), which regulates cell cycle progression, is controlled by its subcellular localization and subsequent degradation. p27(Kip1) is phosphorylated on serine 10 (S10) and threonine 187 (T187)...
  39. pmc Altered p27(Kip1) phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor beta-mediated G(1) arrest
    Sandra Ciarallo
    Molecular and Cell Biology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Canada
    Mol Cell Biol 22:2993-3002. 2002
    p27(Kip1) is an important effector of G(1) arrest by transforming growth factor beta (TGF-beta)...
  40. ncbi ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line
    Rana Varshochi
    Cancer Research UK Laboratories and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, United Kingdom
    J Biol Chem 280:3185-96. 2005
    ....
  41. pmc A novel germline CDKN1B mutation causing multiple endocrine tumors: clinical, genetic and functional characterization
    Sara Molatore
    Institute of Pathology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
    Hum Mutat 31:E1825-35. 2010
    ..Recently, mutations in CDKN1B,encoding the cyclin-dependent kinase (Cdk) inhibitor p27, were identified in patients having a MEN1-like phenotype but no MEN1 gene mutations...
  42. pmc Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins
    R Yang
    Division of Hematology Oncology, Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, California 90048, USA
    Mol Cell Biol 19:2400-7. 1999
    ..Our results suggest that the Rb family of proteins and E2F-1 may be important targets for phosphorylation by the cyclin A1-associated kinase. Cyclin A1 may function in the mitotic cell cycle in certain cells...
  43. doi Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1
    Jun ichi Sakamaki
    Center for Tsukuba Advanced Research Alliance, Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    Biochem Biophys Res Commun 382:497-502. 2009
    ..PARP-1 represses FOXO1-mediated expression of cell cycle inhibitor p27(Kip1) gene...
  44. pmc Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states
    Sunita K Agarwal
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1802, USA
    J Clin Endocrinol Metab 94:1826-34. 2009
    ..However, the prevalence of identifiable germline MEN1 mutations in familial MEN1 cases is only 70%. Some cases may have a germline mutation in another gene such as the p27 cyclin-dependent kinase inhibitor (CDKI).
  45. ncbi Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    K Polyak
    Howard Hughes Medical Institute, Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Cell 78:59-66. 1994
    We cloned p27Kip1, a cyclin-dependent kinase inhibitor implicated in G1 phase arrest by TGF beta and cell-cell contact...
  46. ncbi Downregulation of Skp2 and p27/Kip1 synergistically induces apoptosis in T98G glioblastoma cells
    Sang Hyun Lee
    Cancer Research Institute and Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    J Mol Med (Berl) 83:296-307. 2005
    ..We downregulated Skp2 in T98G glioblastoma cells using small interfering RNA (siRNA). Downregulation induced p27 and caused growth arrest and apoptosis. Downregulation of both Skp2 and p27 increased apoptosis synergistically...
  47. pmc Induction of cell cycle arrest by human T-cell lymphotropic virus type 1 Tax in hematopoietic progenitor (CD34+) cells: modulation of p21cip1/waf1 and p27kip1 expression
    Adam Tripp
    Department of Microbiology and Immunology, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    J Virol 79:14069-78. 2005
    ..Tax1 induced transcriptional upregulation of the cdk inhibitors p21(cip1/waf1) (p21) and p27(kip1) (p27), and marked suppression of hematopoiesis in immature (CD34(+)/CD38(-)) hematopoietic progenitor cells in ..
  48. pmc RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility
    MICHELLE D LARREA
    Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 106:9268-73. 2009
    ..We present evidence that RSK1 drives p27 phosphorylation at T198 to increase RhoA-p27 binding and cell motility...
  49. ncbi The role of p27Kip1 in proteasome inhibitor induced apoptosis
    Hannes C A Drexler
    Max Planck Institute for Physiological and Clinical Research, Department of Molecular Cell Biology, Bad Nauheim, Germany
    Cell Cycle 2:438-41. 2003
    ..Conflicting results have been reported on the role of the CKI p27Kip1 either in promoting or inhibiting apoptosis mediated by proteasome inhibitors and other drugs...
  50. ncbi Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias
    J A Pietenpol
    Johns Hopkins Oncology Center, Baltimore, Maryland 21231
    Cancer Res 55:1206-10. 1995
    The p27Kip1 (p27) gene encodes an inducible inhibitor of cyclin-dependent kinase activity. Using a murine p27 cDNA as probe, we obtained a human cDNA clone and subsequently used it to isolate a genomic clone of this gene...
  51. ncbi A polymorphism in the CDKN1B gene is associated with increased risk of hereditary prostate cancer
    Bao Li Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Res 64:1997-9. 2004
    The loss of cell cycle control is believed to be an important mechanism in the promotion of carcinogenesis. CDKN1B (p27) belongs to the Cip/Kip family and functions as an important cell cycle gatekeeper...
  52. ncbi A molecularly genetic determination of prognostic factors of the prostate cancer and their relationships to expression of protein p27kip1
    J Dvorackova
    CGB laborator spol s r o Ostrava
    Neoplasma 54:149-54. 2007
    ..their relationship to the prognosis of prostate cancer patients in relation to Gleason score and expression of p27Kip1. We chose a subgroup of 17 monitored patients who had died during five years following diagnosis, and a group of ..
  53. ncbi [Expression and significance of Ser10 phosphorylated p27(kip1) and JAB1 protein in human hepatocellular carcinoma]
    Mu dan Lu
    Zhonghua Bing Li Xue Za Zhi 36:840-1. 2007
  54. ncbi Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle
    S Coats
    Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Science 272:877-80. 1996
    ..Murine Balb/c-3T3 fibroblasts deprived of serum mitogens accumulated the cyclin-dependent kinase (CDK) inhibitor p27Kip1. This was correlated with inactivation of essential G1 cyclin-CDK complexes and with cell cycle arrest in G1...
  55. pmc Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc
    J Vlach
    Swiss Institute for Experimental Cancer Research, Epalinges, Switzerland
    EMBO J 15:6595-604. 1996
    We show here that c-Myc antagonizes the cyclin-dependent kinase (CDK) inhibitor p27Kip1. p27 expressed from recombinant retroviruses in Rat1 cells associated with and inhibited cyclin E/CDK2 complexes, induced accumulation of the pRb and ..
  56. ncbi New functional activities for the p21 family of CDK inhibitors
    J LaBaer
    Massachusetts General Hospital Cancer Center, Charlestown 02129, USA
    Genes Dev 11:847-62. 1997
    ..In this report we demonstrate that the CDK inhibitors p21(CIP), p27(KIP), and p57(KIP2) all promote the association of cdk4 with the D-type cyclins...
  57. ncbi Cyclin E-CDK2 is a regulator of p27Kip1
    R J Sheaff
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center FHCRC, Seattle, Washington 98104, USA
    Genes Dev 11:1464-78. 1997
    ..We show that expression of cyclin E-CDK2 in murine fibroblasts causes phosphorylation of the CDK inhibitor p27Kip1 on T187, and that cyclin E-CDK2 can directly phosphorylate p27 T187 in vitro...
  58. ncbi Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest
    J M Kokontis
    Ben May Institute for Cancer Research, University of Chicago, Illinois 60637, USA
    Mol Endocrinol 12:941-53. 1998
    ..the cyclin-dependent kinase (cdk) inhibitor p21waf1/cip1 in 104-R1 cells, while expression of the cdk inhibitor p27Kip1 was persistently induced by androgen in both 104-R1 and 104-R2 cells...
  59. ncbi SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
    A C Carrano
    Department of Pathology, New York University Medical Center, New York 10016, USA
    Nat Cell Biol 1:193-9. 1999
    Degradation of the mammalian cyclin-dependent kinase (CDK) inhibitor p27 is required for the cellular transition from quiescence to the proliferative state...
  60. ncbi Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence
    J Lin
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Oncogene 20:2000-9. 2001
    ..rat fibroblast, only Cdk6-D3 retains kinase activity due mainly to its ability to evade inhibition by p27(KIP1) and p21(CIP1) with a resemblance to viral cyclin-bound Cdk6...
  61. ncbi Low expression of p27(Kip1) is associated with tumor size and poor prognosis in patients with renal cell carcinoma
    Toshiro Migita
    Department of Anatomic Pathology, Kyushu University, Fukuoka, Japan
    Cancer 94:973-9. 2002
    Proliferative activity in tumors depends on regulation of the cell cycle. p27(Kip1) (p27) plays a pivotal role as a negative regulator of the cell cycle...
  62. ncbi Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice
    Jeannette Philipp-Staheli
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 90109, USA
    Cancer Cell 1:355-68. 2002
    Expression of the cyclin-dependent kinase inhibitor p27(Kip1) (p27) is frequently reduced in human colorectal cancer, and this correlates with poor patient prognosis...
  63. ncbi PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest
    Jiyong Liang
    Molecular and Cell Biology, Sunnybrook and Women s College Health Sciences Centre, St Mary s Hospital, McGill University, Montreal, Quebec
    Nat Med 8:1153-60. 2002
    ..to antiproliferative signals and breast cancer progression in part by impairing the nuclear import and action of p27. Akt transfection caused cytoplasmic p27 accumulation and resistance to cytokine-mediated G1 arrest...
  64. ncbi Elevated Skp2 protein expression in human prostate cancer: association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival
    Guang Yang
    Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 8:3419-26. 2002
    ..regulator of G1-S transition and promotes ubiquitin-mediated proteolysis of the cyclin-dependent kinase inhibitor p27. Its overexpression has been implicated in cell transformation and oncogenesis in both in vitro and in vivo models...
  65. ncbi Deregulated degradation of the cdk inhibitor p27 and malignant transformation
    Joanna Bloom
    Department of Pathology and NYU Cancer Instutute, MSB599, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Semin Cancer Biol 13:41-7. 2003
    b>p27 acts as a critical negative regulator of the cell cycle by inhibiting the activity of cyclin/cdk complexes during G0 and G1...
  66. ncbi p27(kip1) functional regulation in human cancer: a potential target for therapeutic designs
    B Belletti
    Division of Experimental Oncology, Centro di Riferimento Oncologico, Via Pedemontana Occidentale, 12, Aviano 33081, Italy
    Curr Med Chem 12:1589-605. 2005
    ..The present review will deal with the role of one of this CKI, p27(kip1), in human cancer, focusing in particular on the mechanisms underlying its functional inactivation in tumor cells...
  67. ncbi p27(kip1) and Ki-67 (MIB1) immunohistochemical expression in radical prostatectomy specimens of patients with clinically localized prostate cancer
    Kyriakos Revelos
    Department of Pathology, Evangelismos General Hospital, Athens, Greece
    In Vivo 19:911-20. 2005
    The immunohistochemical expressions (IE) of p27(kip1) and Ki-67 (MIB-1), both involved in cell cycle regulation and cell proliferation, and their ability to predict biochemical failure, were assessed in patients with clinically localized ..
  68. pmc Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein
    Abdelmajid Sabile
    Institute of Cell Biology, ETH Honggerberg, 8093 Zurich, Switzerland
    Mol Cell Biol 26:5994-6004. 2006
    Ubiquitin-mediated degradation of the cyclin-dependent kinase inhibitor p27 provides a powerful route for enforcing normal progression through the mammalian cell cycle...
  69. ncbi Patterns of expression of cell cycle/apoptosis genes along the spectrum of thyroid carcinoma progression
    Benjamin Saltman
    Department of Otolaryngology, Columbia University College of Physicians and Surgeons, New York, NY 10021, USA
    Surgery 140:899-905; discussion 905-6. 2006
    ..The aim of this study is to determine to what extent cell cycle/apoptosis regulators contribute to cancer progression...
  70. pmc p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2
    Isabel Chu
    Braman Family Breast Cancer Institute of the University of Miami Sylvester Comprehensive Cancer Center and Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Cell 128:281-94. 2007
    The kinase inhibitor p27Kip1 regulates the G1 cell cycle phase. Here, we present data indicating that the oncogenic kinase Src regulates p27 stability through phosphorylation of p27 at tyrosine 74 and tyrosine 88...
  71. doi c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor
    Vidyalakshmi Chandramohan
    Department of Biochemistry, Boston University Medical School, 715 Albany Street, Boston, Massachusetts 02118, USA
    J Cell Biochem 104:2091-106. 2008
    The p27(Kip1) (p27) cyclin-dependent kinase inhibitor and c-Myc oncoprotein play essential roles in control of cell cycle progression and apoptosis...
  72. doi MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
    F Fornari
    1Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Policlinico S Orsola, Bologna, Italy
    Oncogene 27:5651-61. 2008
    ..One proven target of miR-221 is CDKN1B/p27, whose downregulation affects HCC prognosis...
  73. doi Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels
    Daisuke Morishita
    Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, The University of Tokyo, Tokyo, Japan
    Cancer Res 68:5076-85. 2008
    ..family members (Pim1, Pim2, and Pim3) bind to and directly phosphorylate the cyclin-dependent kinase inhibitor p27(Kip1) at threonine-157 and threonine-198 residues in cells and in vitro...
  74. pmc A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression
    Pradip K Majumder
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Cell 14:146-55. 2008
    ..In luminal epithelial cells of Akt-driven PIN, we show the concomitant induction of p27(Kip1) and senescence...
  75. doi Assessment of p27 (cyclin-dependent kinase inhibitor 1B) and aryl hydrocarbon receptor-interacting protein (AIP) genes in multiple endocrine neoplasia (MEN1) syndrome patients without any detectable MEN1 gene mutations
    Susana Igreja
    Department of Endocrinology, Barts and the London School of Medicine, London, UK
    Clin Endocrinol (Oxf) 70:259-64. 2009
    ..endocrine tumours, a phenotypic overlap of both MEN1 and MEN2, has been reported to have a homozygous germline p27 (CDKN1B) mutation...
  76. doi p27Kip1 promotes migration of metastatic hepatocellular carcinoma cells
    Xiao Qi Wang
    Department of Surgery, University of Hong Kong, Hong Kong, SAR, China
    Tumour Biol 29:217-23. 2008
    p27(Kip1) (p27) is a member of the Cip/Kip family of cyclin/cyclin-dependent kinase inhibitors (CKIs), and its CKI-independent function regarding cell motility modulation has been discovered...
  77. doi Immunohistochemically detected expression of p27(Kip1) and Skp2 predicts survival in patients with intrahepatic cholangiocarcinomas
    Nozomi Hashimoto
    Departments of Gastroenterological Surgery, Kagawa University, Miki cho, Kita gun, Kagawa, Japan
    Ann Surg Oncol 16:395-403. 2009
    In intrahepatic cholangiocarcinomas (ICCs), the prognostic significance of p27(Kip1), a cyclin-dependent kinase inhibitor, remains controversial, and there have been no studies of degradation pathway associated proteins, S-phase kinase-..
  78. doi p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function
    Shicheng Liu
    Research and Development Department, Nipro Patch Co, Ltd, Kasukabe, Saitama 344 0057, Japan
    Cancer Lett 286:240-9. 2009
    ..Consistent with blocking the G1-S-phase transition, hinokitiol markedly increased p27 protein levels, but caused only a moderate increase in p21, in addition to a decrease in Cdk2, cyclin E, and ..
  79. pmc The function of p27 KIP1 during tumor development
    Jinhwa Lee
    Department of Clinical Lab Science, Dongseo University, Busan 617 716, Korea
    Exp Mol Med 41:765-71. 2009
    ..One CKI of importance is p27(KIP1)...
  80. pmc Mitogenic regulation of p27(Kip1) gene is mediated by AP-1 transcription factors
    Ekta Khattar
    Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    J Biol Chem 285:4554-61. 2010
    The abundance of cyclin-dependent kinase inhibitor p27(Kip1) during the cell cycle determines whether cells will proliferate or become quiescent...
  81. doi Clinical significance of miR-221 and its inverse correlation with p27Kip¹ in hepatocellular carcinoma
    Xinhui Fu
    Laboratory of Surgery, The First Affiliated Hospital, Sun Yat Sen Zhongshan University, Guangzhou, 510080 Guangdong, People s Republic of China
    Mol Biol Rep 38:3029-35. 2011
    ..adjacent non-cancerous samples were assayed for the expression of miR-221 and three G1/S transition inhibitors: p27(Kip1), p21(WAF1/Cip1)and TGF-β1 by in situ hybridization and immunohistochemistry respectively...
  82. pmc Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization
    Tarig Bashir
    Department of Pathology, New York University Cancer Institute, Smilow Research Center, New York University School of Medicine, New York, NY, USA
    Cell Cycle 9:971-4. 2010
    ..Skp2 is a nuclear F-box protein that targets the CDK inhibitor p27 for ubiquitin- and proteasome-dependent degradation...
  83. ncbi Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2
    Christel Boutonnet
    Institut de Recherche en Immunologie et Cancérologie, Universite de Montreal, Montreal, QC, Canada
    Cell Cycle 9:975-9. 2010
    ..We show here that phosphorylation of Ser72 does not control Skp2 binding to Skp1 and Cul1, has no influence on SCF(Skp2) ubiquitin ligase activity, and does not affect the subcellular localization of Skp2 in a panel of cell lines...
  84. pmc GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1)
    Jeffrey Stein
    Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Chicago, Chicago, IL, USA
    Islets 3:21-34. 2011
    ..Here, we show that p27 (Kip1), a CDK inhibitor, is expressed abundantly in isolated adult human islets and interacts with various positive cell ..
  85. pmc Somatic mutation and germline sequence abnormalities in CDKN1B, encoding p27Kip1, in sporadic parathyroid adenomas
    Jessica Costa-Guda
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030 3101, USA
    J Clin Endocrinol Metab 96:E701-6. 2011
    ..CDKN1B, encoding cyclin-dependent kinase inhibitor p27(kip1), has recently been implicated in a multiple endocrine tumor phenotype in rats and, rarely, in a human familial ..
  86. pmc CDKN1B, encoding the cyclin-dependent kinase inhibitor 1B (p27), is located in the minimally deleted region of 12p abnormalities in myeloid malignancies and its low expression is a favorable prognostic marker in acute myeloid leukemia
    Claudia Haferlach
    MLL, Munich Leukemia Laboratory, Max Lebsche Platz 31, 81377 Munich, Germany
    Haematologica 96:829-36. 2011
    ..Alterations of the short arm of chromosome 12 (12p) occur in various hematologic malignancies and ETV6 and CDKN1B, which are located on 12p, have been implicated as leukemogenic genes of interest...
  87. doi Alterations in TP53, cyclin D2, c-Myc, p21WAF1/CIP1 and p27KIP1 expression associated with progression in B-CLL
    Antosz Halina
    Department of Clinical Genetics, Medical University of Lublin, Lublin, Poland
    Folia Histochem Cytobiol 48:534-41. 2010
    ..We investigated the gene expression of five key cell cycle regulators: TP 53, c-Myc, cyclin D2, p21WAF1/CIP1 and p27KIP1, which primarily regulate the G1 phase of the cell cycle, or S-phase entry and ultimately control the ..
  88. pmc The cell cycle inhibitor p27Kip¹ controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist
    Cristina Menchon
    Center of Regenerative Medicine in Barcelona Barcelona, Spain
    Cell Cycle 10:1435-47. 2011
    ..We identified that the protein expression of the p27(Kip)¹ cell cycle inhibitor is low in hESC cells and increased with differentiation...
  89. doi Undifferentiated embryonic cell transcription factor-1 (UTF1) inhibits the growth of cervical cancer cells by transactivating p27Kip1
    Xiao Ling Wu
    Department of Reproductive Medicine, First Affiliated Hospital, Xi an Jiaotong University of Medical College, Xi an, Shaanxi 710061, China
    Carcinogenesis 34:1660-8. 2013
    ..in vitro and tumorigenesis in vivo through attenuating cell cycle arrest via increasing the level of p27 (Kip1) ...
  90. ncbi p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors
    M V Ponce-Castañeda
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Cancer Res 55:1211-4. 1995
    The p27Kip1 gene codes for a cyclin-dependent kinase inhibitor implicated in G1 arrest by transforming growth factor beta, cell-cell contact, agents that elevate cyclic AMP, and the growth-inhibitory drug rapamycin...
  91. ncbi Translational control of p27Kip1 accumulation during the cell cycle
    L Hengst
    Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 271:1861-4. 1996
    ..The p28lck1 protein was shown to be identical to p27Kip1, and the periodic or induced inhibitory activity resulted from a periodic accumulation of the protein...
  92. ncbi Inactivation of p27Kip1 by the viral E1A oncoprotein in TGFbeta-treated cells
    A Mal
    Department of Molecular Biology, Cleveland Clinic Research Institute, Ohio 44195, USA
    Nature 380:262-5. 1996
    ..4), inactivation of the cyclin E/A-cdk2 complex by the inhibitory protein p27Kip1 (refs 5-7), and with the accumulation of unphosphorylated retinoblastoma protein...
  93. ncbi Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
    A A Russo
    Cellular Biochemistry and Biophysics Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    Nature 382:325-31. 1996
    The crystal structure of the human p27Kip1 kinase inhibitory domain bound to the phosphorylated cyclin A-cyclin-dependent kinase 2 (Cdk2) complex has been determined at 2.3 angstrom...
  94. pmc Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27
    J Vlach
    Swiss Institute for Experimental Cancer Research, CH 1066 Epalinges, Switzerland
    EMBO J 16:5334-44. 1997
    The p27(Kip1) protein associates with G1-specific cyclin-CDK complexes and inhibits their catalytic activity...
  95. ncbi Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade
    B Levkau
    Department of Pathology, University of Washington, Seattle 98195 7470, USA
    Mol Cell 1:553-63. 1998
    ..In apoptotic cells, the C termini of the cdk inhibitors p21Cip1/Waf1 and p27Kip1 are truncated by specific cleavage. The enzyme involved in this cleavage is CPP32 and/or a CPP32-like caspase...
  96. pmc Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A
    B A Schulman
    Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 95:10453-8. 1998
    ..In the x-ray structure of cyclin A-cdk2-p27, this hydrophobic patch contacts the RNLFG sequence in p27 that is common to a number of substrates and inhibitors ..
  97. ncbi Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma
    C Cordon-Cardo
    Memorial Sloan Kettering Cancer, New York, NY 10021, USA
    J Natl Cancer Inst 90:1284-91. 1998
    The p27KIP1 gene, whose protein product is a negative regulator of the cell cycle, is a potential tumor suppressor gene; however, no tumor-specific mutations of this gene have been found in humans...
  98. pmc Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
    A Montagnoli
    Department of Pathology and Kaplan Comprehensive Cancer Center, New York University Medical Center, New York, New York 10016, USA
    Genes Dev 13:1181-9. 1999
    The cellular abundance of the cyclin-dependent kinase (Cdk) inhibitor p27 is regulated by the ubiquitin-proteasome system. Activation of p27 degradation is seen in proliferating cells and in many types of aggressive human carcinomas...
  99. ncbi Retinoic acid induces neuronal differentiation of embryonal carcinoma cells by reducing proteasome-dependent proteolysis of the cyclin-dependent inhibitor p27
    G Baldassarre
    Servizio Oncologia Sperimentale E, Istituto Nazionale Tumori, Naples, Italy
    Cell Growth Differ 11:517-26. 2000
    ..In the present study, we provide a functional link between RA and p27 function in the control of neuronal differentiation in NT2/D1 cells...
  100. ncbi Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor p27Kip1
    Y Sugiyama
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0101, Japan
    J Biol Chem 276:12084-90. 2001
    ..expression of Jab1/CSN5 induces specific down-regulation of the cyclin-dependent kinase (Cdk) inhibitor p27 (p27(Kip1)) in a manner dependent upon transportation from the nucleus to the cytoplasm...
  101. ncbi Exploitation of a non-apoptotic caspase to regulate the abundance of the cdkI p27(KIP1) in transformed lymphoid cells
    V Frost
    School of Biological Sciences, University of Sussex, Brighton, BN1 9QG, UK
    Oncogene 20:2737-48. 2001
    Expression of the cyclin dependent kinase inhibitor p27(KIP1) is intimately linked to the control of proliferation, and is itself regulated by transcription, translation, phosphorylation, protein stability or sequestration...

Research Grants66

  1. B-RAF Regulation of the Cell Cycle in Melanoma
    Andrew E Aplin; Fiscal Year: 2013
    ..cells elevates activation of the MEK-ERK1/2 pathway and regulates two key G1 cell cycle proteins: cyclin D1 and p27Kip1. Our preliminary data indicate that mutant B-RAF signaling and cyclin D1 regulate p27Kip1 via expression of Skp2 ..
  2. CELL CYCLE REGULATION IN NORMAL AND CANCER CELLS
    James M Roberts; Fiscal Year: 2010
    b>p27Kip1 is an evolutionarily conserved protein that regulates both cell proliferation, through inhibitory interactions with cyclins and cyclin-dependent kinases, and cell movement, through its inhibitory interaction with RhoA...
  3. Cell cycle in development and regeneration of the inner ear
    Neil Segil; Fiscal Year: 2011
    ..Changes in the ability of P14 supporting cells to down-regulate p27Kip1 are partly responsible for the block to cell division that results in the lack of regeneration...
  4. Regulation of cyclin D3 in B lymphocyte development
    Marcus R Clark; Fiscal Year: 2013
    ..a novel, lymphoid specific mechanism, controls the subnuclear location of cyclin D3 relative to the inhibitor p27kip1 and the CDK4/Rb effector complex...
  5. Dual role of IL-16 in dysregulated growth of CTCL cells
    William W Cruikshank; Fiscal Year: 2012
    ..regulating degradation of one of the major cyclin kinase inhibitors associated with T cell proliferation, p27kip1. Our preliminary data now indicates that in T cells from CTCL patients there is an initial redistribution of ..
  6. Signal Transduction by the Microtubule Destabilizer, Stathmin/Oncoprotein 18
    Lynne Cassimeris; Fiscal Year: 2012
    ..The other stathmin binding partners, p27Kip1 and STAT3, will be tested for their potential role(s) in regulating cell cycle progression after stathmin ..
  7. Prevention of acute GvHD by inhibition of cdk2
    Vassiliki A Boussiotis; Fiscal Year: 2012
    ..In conjunction with cyclin E, cdk2 phosphorylates the cell cycle inhibitor p27kip1 resulting in ubiquitin-targeted degradation...
  8. Physiologic Regulation of Hematopoiesis by Notch
    Nadia Carlesso; Fiscal Year: 2011
    ..activation of SKP2, the F-box subunit of the SCFskp2 complex that targets the cell cycle inhibitors p27Kip1 and p21Cip1 for degradation, promoting their downregulation and the entry into S-phase...
  9. Bioflavonoid Effects on EGF Signaling and Cell Cycle Pathways in Prostate Cancer
    BARRY MATTHEW MARKAVERICH; Fiscal Year: 2013
    ..These studies may lead to the development of new drugs and/or dietary components for use in cancer prevention or treatment. ..
  10. The role of cyclin E deregulation in breast tumorigenesis
    ALEXANDER C MINELLA; Fiscal Year: 2010
    ..In addition to high cyclin E expression, reduced expression of the cyclin-dependent kinase inhibitor p27Kip1 has also been found to correlate with poor prognosis in breast cancers...
  11. Signaling Pathways in Hepatic Fibrogenesis
    Bruce Bacon; Fiscal Year: 2005
    ..cell cycle, and is dependent on the balance of positive (cyclins, cyclin-dependent kinases; CDK) and negative (p27Kip1) regulatory cell-cycle proteins...
  12. Regulation of CD8 T Cell Immunity by CDK Inhibitor p27Kip1
    Marulasiddappa Suresh; Fiscal Year: 2012
    ..lymphocytic choriomeningitis virus (LCMV) have shown that genetic deficiency of cyclin dependent kinase inhibitor p27Kip1 not only accelerated the differentiation of memory cells from effector CD8 T cells, but also significantly ..
  13. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..showed that the depletion of polyamines in MYCN-amplified NB cells caused G1 cell cycle arrest and affected p27Kip1 levels, retinoblastoma protein Rb phosphorylation, and most intriguingly, blocked MYCN expression, thus providing ..
  14. TARGETED MANIPULATION OF STEM CELLS FOR AIDS THERAPY
    David T Scadden; Fiscal Year: 2010
    ..They defined in detail distinctive phenotypes associated with the genetic deficiency of p21Cip1 (p21), p27Kip1 (p27), p18INK4c (p18) and p16INK4a (p16)...
  15. Thomas S Monahan; Fiscal Year: 2016
    ..1) that MARCKS regulates vascular smooth muscle cell proliferation by up- regulation of the cell cycle inhibitor, p27kip1 2) that MACRKS modulates cell migration by disrupting cellular actin organization and 3) that MARCKS knockout in ..
  16. Ming Hui Zou; Fiscal Year: 2015
    ..Consistent with this finding, the cell cycle inhibitor, p27Kip1 (p27), was dramatically down-regulated in AMPKa2-knock out (KO) mouse VSMC but not AMPKa1-KO VSMC...
  17. James L Mohler; Fiscal Year: 2014
    ..the influence of MAGE-11 and Rb/p107 on Skp2 stimulation of cell proliferation through the degradation of the p27-Kip1 tumor suppressor...
  18. Regulation and Role of Ornithine Decarboxylase in Cell Proliferation and Cancer
    John L Cleveland; Fiscal Year: 2013
    ..by selectively affecting Myc's ability to provoke the degradation of the cyclin- dependent kinase inhibitor p27Kip1, a tumor suppressor that inhibits entry and progression through S-phase...
  19. Michael Sobel; Fiscal Year: 2015
    ..We have studied a single nucleotide polymorphism (-838 C>A) in the promoter of the p27Kip1 gene (CDKN1B), an important cyclin-dependent kinase inhibitor, in four separate clinical trials encompassing 3279 ..
  20. Role of Reactive Oxygen Species in B Lymphoma Fate
    Gregory B Carey; Fiscal Year: 2012
    ..g. c-Myc, Akt, CDK2 and p27Kip1)...
  21. Zheng Yi Chen; Fiscal Year: 2015
    ..Deletion of negative growth genes (Rb1 and p27kip1) led to cell cycle re-entry in embryonic and neonatal inner ear...
  22. Peggy L Porter; Fiscal Year: 2014
    ..Project 1 will apply basic discovery of p27kip1 cell cycle regulation in breast cancer to predict mortality and response to therapy...
  23. Requirements for Normal Rb Function In Vivo
    David W Goodrich; Fiscal Year: 2010
    ..Another possible mechanism involves targeted degradation of Skp2 by pRb and consequent stabilization of p27Kip1. The ability of pRb to regulate E2F transcription factors is genetically separable from its ability to degrade ..
  24. HER-2/IGF-IR cross-talk and Herceptin resistance
    Rita Nahta; Fiscal Year: 2010
    ..HER-2 in this complex is phosphorylated, suggesting cross-talk from IGF-IR to HER-2;2) p27kip1, which lies downstream of both HER-2 and IGF-IR, is downregulated in resistant cells...
  25. Mechanisms of p27Kipl Proteolysis in Cancer Cells
    Xuedong Liu; Fiscal Year: 2012
    Decreased levels of cell cycle inhibitor p27Kip1 due to excessive degradation occur in a variety of aggressive human tumors...
  26. Nagi G Ayad; Fiscal Year: 2014
    ..The APC degrades the ubiquitin ligase component Skp2, which allows p27kip1 levels to rise, thereby inducing cell cycle exit...
  27. P27Kipl deficiency, potential promoter of carcinogenesis
    Konstantin Christov Tzelkov; Fiscal Year: 2003
    ..We will examine the feasibility of p27/Kip1 deficiency in transgenic mice for potential use in mammary carcinogenesis studies in chemopreventive studies...
  28. Prevention of Menopause-Related Ovarian Epithelial Cancer
    Elizabeth R Smith; Fiscal Year: 2010
    ..When deletion of the cyclin-dependent kinase inhibitor p27kip1 gene, whose expression is often lost in ovarian cancer, is added to the Wv/Wv genotype, the ovarian tumors ..
  29. Role of Skp2-cyclin A Interaction in Normal Physiology and Cancer
    Liang Zhu; Fiscal Year: 2013
    ..Skp2 is an F-box protein of the SCF(Skp2) ubiquitin ligase complex targeting p27Kip1 for ubiquitination...
  30. MECHANISM OF RETROCORNEAL FIBROUS MEMBRANE
    EunDuck P Kay; Fiscal Year: 2010
    ..We showed that there are distinct populations of p27Kip1 (p27) that employ differential kinetics of phosphorylation, ubiquitination and degradation, suggesting that CECs ..
  31. TUMORIGENESIS AND NEUROGENESIS OF P27 KIP1 KNOCKOUT MICE
    Li Huei Tsai; Fiscal Year: 1999
    ..This view is supported by the phenotype which we have observed in mice harboring a homozygous deletion of the p27 kip1 gene...
  32. Regulation of Vascular Smooth Muscle Cell Proliferation
    Hana Totary Jain; Fiscal Year: 2010
    ..will test the hypothesis that diabetes leads to an overstimulation of the PI3K/Akt/Foxo pathway', decreasing p27Kip1 gene expression, conferring relative rapamycin resistance...
  33. REGULATION OF CELL PROLIFERATION IN THE ORGAN OF CORTI
    Ping Chen; Fiscal Year: 2001
    ..We found that p27Kip1, a cell division inhibitor, plays an essential growth inhibitory role during development of the organ of Corti...
  34. CELL CYCLE IN OLIGODENDROCYTE DEVELOPMENT
    Robin Miskimins; Fiscal Year: 2000
    ..of oligodendrocyte progenitor cells is accompanied by a marked increase in the cyclin dependent kinase inhibitor p27kip1 (and a decrease in cyclin E)...
  35. XIANGXI MIKE XU; Fiscal Year: 2014
    ..Furthermore, addition of oncogenic mutation such as loss of p27kip1 or loss of p53 converts the ovarian adenomas into neoplastic tumors...
  36. Lewis H Romer; Fiscal Year: 2014
    ..mediates OxLDL activation of Arg2 through LOX-1 and the following signaling intermediaries: MT1-MMP, p27kip1, RhoA, ROCK, and mDia1...
  37. CONTRACT #N43-CO-95012-616 MONTHS FUNDING -PHASE 1 TOPIC 265 DEVELOPMENT OF SHRN
    Xiao Zeng; Fiscal Year: 2009
    ..Phase I, Develop and screen a focused, FV shRNA collection to identify factors that are involved in the MCL-1 and p27kip1 signaling pathways...
  38. ECM MATRIX, PROTEASE AND MELANOMA PROLIFERATION
    Yves DeClerck; Fiscal Year: 2007
    ..interphase and that this arrest involves a specific up-regulation of the cell cyclin dependent kinase inhibitor p27KIP1 (Henriet et al., PNAS, 97:10026-10031, 2000)...
  39. Regulation of Bladder Smooth Muscle Hyperplasia
    Paul Austin; Fiscal Year: 2007
    ..to varying degrees of resistance to contraction, the candidate has found that the cell cycle control protein p27KIP1 is downregulated by the development of increased tension within the SMC...
  40. MECHANISMS OF CELL CYCLE CONTROL DURING MAMMARY GLAND DE
    Hui Zhang; Fiscal Year: 2001
    ..We found that SKP2 specifically binds to and targets the CDK inhibitor p27Kip1 for ubiquitin- dependent proteolysis during the G1/S transition...
  41. Prostate Cancer Chemoprevention by Inositol Hexaphosphate Efficacy and Mechanism
    Rajesh Agarwal; Fiscal Year: 2010
    ..In PCA cell culture, completed studies by us show that IP6 up- regulates CDKI Kip1/p27 and Cip1/p21 levels together with their increased interaction with CDKs causing inhibition in the kinase ..
  42. Alcohol and Impairment of the Granulopoietic Response to Pneumonia
    Ping Zhang; Fiscal Year: 2010
    ..also activates signal transducer and activator of transcription 3 (STAT3)-cyclin-dependent kinase (CDK) inhibitor p27Kip1 pathway that provides a negative feedback signal to cause G1 cell cycle arrest...
  43. DIET,APOPTOSIS AND COLON CARCINOGENESIS
    Joanne Lupton; Fiscal Year: 2004
    ..Determine in vivo expression of Cox-2, apoptosis, p21waf1/CipI p27kip1, Cyclin Dl, cell proliferation and differentiation as a function of dietary lipid, butyrate, and carcinogen ..
  44. MOLECULAR-GENETIC ANALYSIS OF 3P14 GENOMIC STABILITY
    Harry Drabkin; Fiscal Year: 2006
    ..and JAB 1 has also been shown to regulate nuclear-cytoplasmic transport and proteasome-mediated degradation of p27 kip1, which is characteristically abnormal in RCCs and which has been linked to VHL mutations...
  45. NUTRITIONAL FACTORS IN MAMMALIAN DEVELOPMENT
    Carl Keen; Fiscal Year: 2009
    ..of both P13K and MAPK signaling pathways, which results in the down-regulation of the cell cycle inhibitor, p27/kip1, and the cytosolic sequestration and phosphorylation of the pro-apoptotic protein, BAD...
  46. Nutritional mechanisms and intestinal tumorigenesis
    Leonard Augenlicht; Fiscal Year: 2009
    ..We have determined that intestinal tumor formation in mice with targeted inactivation of the cdk inhibitor p27kip1 is strictly a function of diet: very few tumors form in p27+/- or p27-/- mice fed chow diet, but tumor formation ..
  47. Cell cycle control of vascular remodeling
    RICHARD ASSOIAN; Fiscal Year: 2009
    ..find that these positive and negative regulators act largely by controlling levels of the cdk inhibitory protein, p27kip1. Moreover, this convergence is also seen in the regulation of Skp2, the E3 ubiquitin ligase that controls the ..
  48. IRREVERSIBLE GROWTH ARREST AND SQUAMOUS DIFFERENTIATION
    BETH HARVAT; Fiscal Year: 2001
    ..p130, p27KiP1 and p16ink4a are growth inhibitory proteins that are up regulated during the multi-step process of squamous ..
  49. RETINOIDS FOR TREATMENT OF OVARIAN CARCINOMA
    KENNETH SOPRANO; Fiscal Year: 2007
    ..IRA treatment of CA-OV3 cells resulted in a significant enhancement in the levels of RB-2/p130 and p27kip1 protein...
  50. Cellular regeneration in the organ of Corti
    Jonathan Kil; Fiscal Year: 2003
    ..The cyclin-dependent kinase inhibitor, p27Kip1, is expressed in the supporting cells of mice from birth through adulthood...
  51. p57KIP2 in Hematopoiesis and Leukemogenesis
    JOSEPH SCANDURA; Fiscal Year: 2009
    ..While p21WAF/CIP1 controls normal murine hematopoietic stem cell quiescence, p27KIP1 regulates the pool of more mature progenitors...
  52. P27kip1 as an early effector of pRB function
    Liang Zhu; Fiscal Year: 2004
    ..We therefore hypothesize that p27 is an early effector of pRB function...
  53. Mouse Models of Tumor Progression and Therapy Response
    CHRISTOPHER KEMP; Fiscal Year: 2007
    ..Reduced expression of the cdk inhibitor p27/Kip1 is frequently observed in a wide range of human tumors and this correlates with poor prognosis...
  54. Growth Regulation of the Normal & Malignant Endometrium
    LESLIE GOLD; Fiscal Year: 2003
    ..Smad2/3,that activate genes that block cell cycle progression, such as the cyclin-dependent kinase inhibitor, p27kip1 We have shown that UtE isolated from all grades of ECA escape negative growth control by TGF-b by incurring ..
  55. Pathways in p27-associated hematolymphoid malignancy
    Harry Hwang; Fiscal Year: 2007
    The overall goals of this research proposal are to understand the mechanisms of tumor suppression by the p27kip1 protein in hematopoietic malignancies. P27 is a cyclin-dependent kinase inhibitor that negatively regulates cell division...
  56. IMAGING IN RISK ASSESSMENT OF PROSTATE CANCER PATIENTS
    Hedvig Hricak; Fiscal Year: 2010
    ..the expression of key molecular markers known to be important in prostate cancer biology: Ki-67, PTEN, Akt, p27/Kip1, Bax, and Bcl-2...
  57. Folate Targeted Delivery of a CDKI
    Joseph Reddy; Fiscal Year: 2003
    ..is that folate-targeted liposomes containing a stabilized version of the cyclin dependent kinase inhibitor, p27Kip1, will block tumor cell growth in vivo...
  58. The molecular role of lkaros in leukemogenesis
    Susan Winandy; Fiscal Year: 2009
    ..We have also identified the cell cycle regulator, p27kip1, as a potential genetic target for transcriptional activation by Ikaros...
  59. Targeting p27kip1 to Improve Hepatocyte Transplantation
    Erin Ochoa; Fiscal Year: 2009
    In characterizing the cell-cycle regulatory role of the cyclin-dependent kinase inhibitor, p27kip1, it was discovered that p27 knockout mice exhibit pronounced multi-organomegaly with no increased spontaneous carcinogenesis in the liver...
  60. P27Kip1 in Myc-induced Apoptosis and Lymphomagenesis
    Jennifer Old; Fiscal Year: 2003
    ..that there are links between the ability of Myc to downregulate the cyclin dependent kinase inhibitor p27 Kip1 and to suppress the expression of Bcl-2...
  61. The role of p27kip1 in T-cell responses
    Vassiliki Boussiotis; Fiscal Year: 2003
    ....
  62. mIgM and mIgD Receptor Signaling in B Lymphoma Apoptosis
    Gregory Carey; Fiscal Year: 2006
    ..both stimulate c-Myc, only anti-mu, ultimately ablates c-Myc protein expression and mediates a large induction of p27Kip1 protein...
  63. CHARACTERIZATION OF A TUMOR SUPPRESSOR GENE ON 9P
    Olufunmilayo Olopade; Fiscal Year: 1999
    ..This gene is an attractive candidate for a TSG because loss of its normal function as an inhibitor of CDKN4, a cyclin dependent kinase could lead to uncontrolled cell growth...
  64. Mechanism of tumor suppression by p27
    Matthew Fero; Fiscal Year: 2003
    ..Fero to further our understanding of tumor suppression by the cell cycle inhibitor (CKI) gene p27kip1, while making a transition in his career from the position of a mentored researcher to an independent ..
  65. P27Kip1 in Hepatocyte Proliferation
    Liang Zhu; Fiscal Year: 2006
    ..Targeted inactivation of p27 in the mouse results in proportionally enlarged animals with multi-organomegaly...
  66. DETAILED ANALYSIS OF P21/CDK2 INTERACTION
    F Germino; Fiscal Year: 2001
    ..domain of p21 to an approximately 35 amino acid region near the gene's 5'end which shares homology with p27Kip1, another CDK inhibitor induced by TGFbeta...