p230

Summary

Gene Symbol: p230
Description: golgin A4
Alias: CRPF46, GCP2, GOLG, MU-RMS-40.18, p230, golgin subfamily A member 4, 256 kDa golgin, 72.1 protein, centrosome-related protein F46, golgi autoantigen, golgin subfamily a, 4, golgin-240, golgin-245, protein 72.1, trans-Golgi p230
Species: human

Top Publications

  1. pmc Interaction between the N-terminal domain of the 230-kDa subunit and the TATA box-binding subunit of TFIID negatively regulates TATA-box binding
    T Kokubo
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 91:3520-4. 1994
  2. doi Isolation of two Locust protein targets of a protein tyrosine phosphatase from Metarhizium anisopliae strain CQMa102
    Zhenlun Li
    Genetic Engineering Research Center, Bioengineering College, Chongqing University, Chongqing 400030, China
    J Invertebr Pathol 99:151-5. 2008
  3. ncbi GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network
    Michael R Luke
    Russell Grimwade School of Biochemistry and Molecular Biology, The University of Melbourne, Victoria 3010, Australia
    J Biol Chem 278:4216-26. 2003
  4. ncbi Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis
    Koiti Inokuchi
    Division of Hematology, Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Blood 102:320-3. 2003
  5. ncbi Identification of TFIID components required for transcriptional activation by upstream stimulatory factor
    T Kokubo
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:17554-8. 1993
  6. pmc Structural requirements for localization and activation of protein kinase C mu (PKC mu) at the Golgi compartment
    Angelika Hausser
    Institute of Cell Biology and Immunology, University of Stuttgart, 70569 Stuttgart, Germany
    J Cell Biol 156:65-74. 2002
  7. ncbi [A geometrical model for the perceived line of orientation based on subjective evaluations and human VEP data]
    Ch A Izmailov
    Lomonosov State University, Moscow
    Zh Vyssh Nerv Deiat Im I P Pavlova 54:237-49. 2004
  8. ncbi Functional effects of amino acid substitutions within the large binding pocket of the phosphotriesterase OpdA from Agrobacterium sp. P230
    Irene Horne
    CSIRO Entomology, Canberra ACT, Australia
    FEMS Microbiol Lett 259:187-94. 2006
  9. doi Concomitant tumor and autoantigen vaccination supports renal cell carcinoma rejection
    Nicolás Herbert
    Department of Tumor Cell Biology, University Hospital of Surgery, University of Heidelberg, Germany
    J Immunol 185:902-16. 2010
  10. pmc Molecular identification of β-citrylglutamate hydrolase as glutamate carboxypeptidase 3
    Francois Collard
    de Duve Institute and Université catholique de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    J Biol Chem 286:38220-30. 2011

Research Grants

  1. Kim C Williamson; Fiscal Year: 2014
  2. ROLE OF CHEMOKINES IN T CELL MEDIATED COLITIS
    James Lillard; Fiscal Year: 2002
  3. ANTI-GAL IGG ON HUMAN RED CELLS: A MODEL FOR CELL AGING
    Uri Galili; Fiscal Year: 1993
  4. BCR/ABL SIGNALING IN HUMAN LEUKEMIAS
    Ann Marie Pendergast; Fiscal Year: 2003
  5. APPLIED BISYSTEMS PRISM 3100 GENETIC ANALYZER
    Edward Chan; Fiscal Year: 2002
  6. GOLGI COMPLEX ANTIBODIES AND AUTOANTIGENS
    Edward Chan; Fiscal Year: 2004
  7. International Workshop on Autoantibodies & Autoimmunity
    Edward Chan; Fiscal Year: 2005
  8. GLUCOCORTICOID ATTENUATED RESPONSE GENES IN INFLAMMATION
    Jeffrey Smith; Fiscal Year: 2001
  9. Regulation of Hematopoiesis by Notch Receptors
    James Griffin; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications154 found, 100 shown here

  1. pmc Interaction between the N-terminal domain of the 230-kDa subunit and the TATA box-binding subunit of TFIID negatively regulates TATA-box binding
    T Kokubo
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 91:3520-4. 1994
    ..Previously, the largest subunit of TFIID (p230) was cloned and demonstrated to inhibit the TATA-box binding of TBP in the absence of other subunits...
  2. doi Isolation of two Locust protein targets of a protein tyrosine phosphatase from Metarhizium anisopliae strain CQMa102
    Zhenlun Li
    Genetic Engineering Research Center, Bioengineering College, Chongqing University, Chongqing 400030, China
    J Invertebr Pathol 99:151-5. 2008
    ..migratoria hemolymph. One phosphoprotein was identified as trans-Golgi p230. Previous studies have shown that trans-Golgi p230 participates in vesicular transport of functional proteins from ..
  3. ncbi GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network
    Michael R Luke
    Russell Grimwade School of Biochemistry and Molecular Biology, The University of Melbourne, Victoria 3010, Australia
    J Biol Chem 278:4216-26. 2003
    ..Previously we demonstrated that the GRIP domain of p230/golgin245 is specifically recruited to tubulovesicular structures of the trans-Golgi network (TGN)...
  4. ncbi Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis
    Koiti Inokuchi
    Division of Hematology, Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Blood 102:320-3. 2003
    b>P230 Bcr/Abl has been associated with indolent myeloproliferative disease (MPD)...
  5. ncbi Identification of TFIID components required for transcriptional activation by upstream stimulatory factor
    T Kokubo
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:17554-8. 1993
    ..the relevance of the Drosophila TFIID components identified in this analysis, including the previously unrecognized p230 (Dynlacht, B. D., Hoey, T., and Tjian, R...
  6. pmc Structural requirements for localization and activation of protein kinase C mu (PKC mu) at the Golgi compartment
    Angelika Hausser
    Institute of Cell Biology and Immunology, University of Stuttgart, 70569 Stuttgart, Germany
    J Cell Biol 156:65-74. 2002
    ..PKC mu-green fluorescent protein fusion proteins costained with the Golgi compartment-specific markers p24 and p230. Deletions of either the NH(2)-terminal hydrophobic or the cysteine region, but not of the pleckstrin homology or ..
  7. ncbi [A geometrical model for the perceived line of orientation based on subjective evaluations and human VEP data]
    Ch A Izmailov
    Lomonosov State University, Moscow
    Zh Vyssh Nerv Deiat Im I P Pavlova 54:237-49. 2004
    ..the activity of the first channel affects the interpeak amplitudes of both the P1-N2 (P130-N180) and N2-P2 (N180-P230) components, whereas the second channel affects only the late component N180-P230...
  8. ncbi Functional effects of amino acid substitutions within the large binding pocket of the phosphotriesterase OpdA from Agrobacterium sp. P230
    Irene Horne
    CSIRO Entomology, Canberra ACT, Australia
    FEMS Microbiol Lett 259:187-94. 2006
    The phosphotriesterase OpdA from Agrobacterium sp. P230 has about 10-fold higher activity for dimethyl organophosphate (OP) insecticides, than its homologue from Flavobacterium sp. ATCC27551, organophosphate hydrolase (OPH)...
  9. doi Concomitant tumor and autoantigen vaccination supports renal cell carcinoma rejection
    Nicolás Herbert
    Department of Tumor Cell Biology, University Hospital of Surgery, University of Heidelberg, Germany
    J Immunol 185:902-16. 2010
    ..Activation of autoantigen-specific Th cells strongly supports tumor-specific Th cells and thereby CTL activation...
  10. pmc Molecular identification of β-citrylglutamate hydrolase as glutamate carboxypeptidase 3
    Francois Collard
    de Duve Institute and Université catholique de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    J Biol Chem 286:38220-30. 2011
    ..suggested that β-citrylglutamate hydrolase belonged to the same family of protein as glutamate carboxypeptidase 2 (GCP2), the enzyme that catalyzes the hydrolysis of N-acetyl-aspartylglutamate...
  11. ncbi BCR/ABL1 fusion transcripts generated from alternative splicing: implications for future targeted therapies in Ph+ leukaemias
    P Chiarella
    Laboratory of Molecular Medicine and Biotechnology, CIR, University Campus Bio Medico of Rome, Via A del Portillo 21, 00128 Rome, Italy
    Curr Mol Med 12:547-65. 2012
    ..rearrangements involving both BCR and ABL1 genes generate a variety of chimeric proteins (BCR/ABL1 p210, p190 and p230) which are considered pathological "biomarkers"...
  12. doi Analysis of the clinico-hematological relevance of the breakpoint location within M-BCR in chronic myeloid leukemia
    Ayda Bennour
    Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia
    Med Oncol 30:348. 2013
    ..been described depending on the length of the sequence of the BCR gene included that encode for the P190, P210, P230 proteins...
  13. pmc Fission yeast MOZART1/Mzt1 is an essential γ-tubulin complex component required for complex recruitment to the microtubule organizing center, but not its assembly
    Hirohisa Masuda
    Laboratory of Cell Regulation, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London WC2A 3LY, United Kingdom Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi Hiroshima 739 8530, Japan
    Mol Biol Cell 24:2894-906. 2013
    ..Mzt1 is present in approximately equal stoichiometry with Alp4/GCP2 and localizes to all the MTOCs, including the SPB and interphase and equatorial MTOCs...
  14. doi Chromosome painting reveals multiple rearrangements between Gymnotus capanema and Gymnotus carapo (Gymnotidae, Gymnotiformes)
    C Y Nagamachi
    Laboratorio de Citogenetica, ICB, Universidade Federal do Para, Belem, Brazil
    Cytogenet Genome Res 141:163-8. 2013
    ..correspond to individual chromosomes (GCP8 and GCP15), while the other 2 share homology with parts of GCP1 and GCP2, respectively...
  15. pmc Microtubule initiation from the nuclear surface controls cortical microtubule growth polarity and orientation in Arabidopsis thaliana
    Chris Ambrose
    Department of Botany, The University of British Columbia, Vancouver V6T 1Z4, Canada
    Plant Cell Physiol 55:1636-45. 2014
    ..We used green fluorescent protein (GFP)-tagged gamma tubulin-complex protein 2 (GCP2) to identify nuclear MTOC activity and GFP-tagged End-Binding Protein 1b (EB1b) to track microtubule growth ..
  16. doi Brain signatures of perceiving a smile: Time course and source localization
    David Beltran
    Department of Cognitive Psychology, University of La Laguna, Tenerife, Spain
    Hum Brain Mapp 36:4287-303. 2015
    ..revealed a specific "anger effect," with greater activity for angry versus non-angry expressions (right N170 and P230; right pSTS and IPL); and a coarse "emotion effect," with greater activity for happy and angry versus neutral ..
  17. ncbi TaqMan RT-PCR assay coupled with capillary electrophoresis for quantification and identification of bcr-abl transcript type
    Rajyalakshmi Luthra
    Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    Mod Pathol 17:96-103. 2004
    ..1 (e1), 13 (b2), or 14 (b3), or rarely to exon 19 (e19) of bcr resulting in chimeric proteins of p190, p210 and p230, respectively...
  18. ncbi Molecular cloning of LIM homeodomain transcription factor Lhx2 as a transcription factor of porcine follicle-stimulating hormone beta subunit (FSHβ) gene
    Takako Kato
    Institute of Reproduction and Endocrinology, Meiji University, Kanagawa 214 8571, Japan
    J Reprod Dev 58:147-55. 2012
    ..development showed a gradual increase from fetal day (f) 40 to postnatal day (p) 8 followed by a slight decrease to p230, suggesting that LHX2 may play its role largely in the late fetal and postnatal periods...
  19. ncbi Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids
    W S Modi
    Intramural Research Support Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    Genomics 47:136-9. 1998
    ..Nine genes, PF4, PF4V1, GRO1, GCP2, PPBP, IL8, GRO2, GRO3, and SCYB5, were assigned within a 1.8-cR interval of one another on 4q...
  20. ncbi Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex
    L W McMahon
    Department of Pathology, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey 07103, USA
    J Biol Chem 274:32904-8. 1999
    ..The FANCA gene appears to play a role in the stability or expression of this protein. We now show that p230 is a well known structural protein, human alpha spectrin II (alphaSpIISigma*), and that levels of alphaSpIISigma* ..
  21. ncbi Physiological and genetic characteristics of two bacterial strains utilizing phenoxypropionate and phenoxyacetate herbicides
    R H Muller
    UFZ Centre for Environmental Research, Department of Environmental Microbiology, Leipzig, Germany
    Microbiol Res 156:121-31. 2001
    Two strains, Rhodoferax sp. P230 and Delftia (Comamonas) acidovorans MCI, have previously been shown to carry activities for the degradation of the two enantiomers of (RS)-2-(2,4-dichlorophenoxy-)propionate (dichlorprop) and (RS)-2-(4-..
  22. ncbi Morphologic and molecular characterization of Salmonella typhimurium infection in neonatal calves
    R L Santos
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station 77843 4467, USA
    Vet Pathol 39:200-15. 2002
    ..typhimurium results in an acute neutrophilic inflammatory response that is associated with the upregulation of CXC chemokines (IL-8, GROalpha and gamma, and GCP2), IL-1beta, IL-IRa, and IL-4.
  23. ncbi Bcr-abl-positive cells secrete angiogenic factors including matrix metalloproteinases and stimulate angiogenesis in vivo in Matrigel implants
    A Janowska-Wieczorek
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Leukemia 16:1160-6. 2002
    ..First, we examined murine FL5.12 cells transfected with the bcr-abl constructs p185, p210 and p230 and found that the transfected cells secreted as much as four-fold more VEGF (p185 > p210 >p230) than wild-..
  24. ncbi Genetic determinants of the homocysteine level
    Gere Sunder-Plassmann
    Department of Medicine III, Division of Nephrology and Dialysis and Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Vienna, Austria
    Kidney Int Suppl . 2003
    ..Because Hcy metabolism is impaired in renal failure, MTHFR 677 C>T, GCP2 1561C>T, RFC1 80G>A, and TCN2 776G>C may further aggravate hyperhomocysteinemia in these patients...
  25. ncbi A role for GRIP domain proteins and/or their ligands in structure and function of the trans Golgi network
    Atsuko Yoshino
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Sci 116:4441-54. 2003
    tGolgin-1 (golgin-245, trans golgi p230) and golgin-97 are members of a family of peripheral membrane proteins of unknown function that localize to the trans Golgi network (TGN) through a conserved C-terminal GRIP domain...
  26. pmc African swine fever virus causes microtubule-dependent dispersal of the trans-golgi network and slows delivery of membrane protein to the plasma membrane
    Christopher L Netherton
    Pirbright Laboratory, Institute for Animal Health, Ash Road, Pirbright, Surrey GU24 0NF, United Kingdom
    J Virol 80:11385-92. 2006
    ..Golgin p230 and TGN46 are separated into distinct vesicles, whereupon TGN46 is depleted...
  27. pmc PIKfyve regulation of endosome-linked pathways
    Jane de Lartigue
    Secretory Pathways Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Traffic 10:883-93. 2009
    ..We suggest that PIKfyve inhibition may render the late endosome/lysosome compartment refractory to fusion with both autophagosomes and with EGFR-containing multivesicular bodies...
  28. doi Eukaryotic GCP1 is a conserved mitochondrial protein required for progression of embryo development beyond the globular stage in Arabidopsis thaliana
    Kirsten Haussuehl
    QIAGEN GmbH, Qiagen Strasse 1, DE 40724 Hilden, Germany
    Biochem J 423:333-41. 2009
    ..Our survey of genome databases revealed that all eukaryotic organisms contain two GCP genes [called GCP1 and GCP2/Kae1 (kinase-associated endopeptidase 1)], whereas prokaryotes have only one, either of the GCP1- (Bacteria) or the ..
  29. doi Novel role of pleckstrin homology domain of the Bcr-Abl protein: analysis of protein-protein and protein-lipid interactions
    Daria Miroshnychenko
    Institute of Molecular Biology and Genetics NAS of Ukraine, Zabolotnogo str, 150 Kyiv 03143, Ukraine
    Exp Cell Res 316:530-42. 2010
    ..There are three Bcr-Abl chimeras known so far, p190, p210 and p230. The only structural difference between the three Bcr-Abl proteins is the presence of DH and PH domains from the ..
  30. pmc Intracellular mannose binding lectin mediates subcellular trafficking of HIV-1 gp120 in neurons
    C Teodorof
    Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA
    Neurobiol Dis 69:54-64. 2014
    ..Thus, our findings suggest that intracellular MBL mediates subcellular trafficking and transport of viral glycoproteins in a microtubule-dependent mechanism in the neurons. ..
  31. pmc Precocious leaf senescence by functional loss of PROTEIN S-ACYL TRANSFERASE14 involves the NPR1-dependent salicylic acid signaling
    Xin Ying Zhao
    State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai an, 271018, China
    Sci Rep 6:20309. 2016
    ..By confocal fluorescence microscopy, we showed that PAT14 is localized at the Golgi, the trans-Golg network/early endosome, and prevacuolar compartments, indicating its roles through vacuolar trafficking...
  32. ncbi Characterization of the Microbial Diversity and Chemical Composition of Gouda Cheese Made by Potential Probiotic Strains as an Adjunct Starter Culture
    Nam Su Oh
    R and D Center, Seoul Dairy Cooperative, Ansan, Kyunggi 15407, South Korea
    J Agric Food Chem 64:7357-7366. 2016
    ..Gouda cheese made with H4 (GCP1) and H9 (GCP2) demonstrated the highest production of formic acid and propionic acid, respectively...
  33. pmc Functional Analysis of γ-Tubulin Complex Proteins Indicates Specific Lateral Association via Their N-terminal Domains
    Dorian Farache
    From the Centre de Biologie du Développement, CNRS Université Toulouse III, 31062 Toulouse, France and
    J Biol Chem 291:23112-23125. 2016
    ..Small complexes (γTuSCs) comprise two molecules of γ-tubulin bound to the C-terminal domains of GCP2 and GCP3...
  34. pmc The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p
    S M Murphy
    Department of Biological Sciences, Stanford University, Stanford, California
    J Cell Biol 141:663-74. 1998
    ..b>GCP2 and GCP3 colocalize with gamma-tubulin at the centrosome, cosediment with gamma-tubulin in sucrose gradients, and ..
  35. ncbi A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins
    L Kjer-Nielsen
    Department of Pathology and Immunology, Monash University Medical School, Melbourne, Victoria, Australia 3181
    Curr Biol 9:385-8. 1999
    ..Previously, we have identified a carboxy-terminal domain of the trans-Golgi-network (TGN) protein p230 that is responsible for Golgi localisation [1]...
  36. ncbi [Functional arrangement of genomic DNA and structure of nuclear matrix]
    Y Hibino
    School of Medicine, Toyama Medical and Pharmaceutical University, Japan
    Yakugaku Zasshi 120:520-33. 2000
    ..We have shown that an MAR binding protein, P230, is detectable in rat hepatoma cells but not in normal liver, and suggested that this protein is a diagnostic and ..
  37. ncbi ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins
    H Van Valkenburgh
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 3050, USA
    J Biol Chem 276:22826-37. 2001
    ..These data reveal a complex network of interactions between GTPases in the ARF family and their effectors and reveal a potential for cross-talk not demonstrated previously...
  38. ncbi Early endosomes, late endosomes, and lysosomes display distinct partitioning strategies of inheritance with similarities to Golgi-derived membranes
    Kate Dunster
    Department of Pathology and Immunology, Monash Medical School, Prahran, Victoria, Australia
    Eur J Cell Biol 81:117-24. 2002
    ..We conclude a portion of endosomal compartments and Golgi-derived membranes undergo ordered partitioning based on the centrosome and mitotic spindle...
  39. ncbi Cytogenetic and molecular genetic aspects of chronic myeloid leukaemia
    David J Barnes
    Department of Haematology, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, UK
    Acta Haematol 108:180-202. 2002
    ..disease phenotypes are associated with each of the three Bcr-Abl oncoproteins, p190(Bcr-Abl), p210(Bcr-Abl )and p230(Bcr-Abl)...
  40. ncbi Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5
    Jeffrey B Smith
    Pediatrics Neonatology B2 325, MDCC, David Geffen School of Medicine and Mattel Children s Hospital at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1752, USA
    Immunogenetics 54:599-603. 2002
    ..The sequence and mapping data suggest that the human ENA78-PBP-PF4 and GCP2- psi PBP-PF4V1 loci arose from an evolutionarily recent duplication of an ancestral locus related to the murine Lix-..
  41. ncbi The phosphotriesterase gene opdA in Agrobacterium radiobacter P230 is transposable
    Irene Horne
    CSIRO Entomology, GPO Box 1700, Canberra, ACT 2601, Australia irene horne
    FEMS Microbiol Lett 222:1-8. 2003
    We report a transposase gene (tnpA) upstream of the opdA phosphotriesterase gene of Agrobacterium radiobacter P230, as well as inverted repeats indicative of insertion sequences, flanking the two genes...
  42. ncbi Deletion mapping using quantitative real-time PCR identifies two distinct 3p21.3 regions affected in most cervical carcinomas
    Vera Senchenko
    Microbiology and Tumor Biology Center, Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, 17177 Sweden
    Oncogene 22:2984-92. 2003
    ..The results strongly suggest that 3p21.3T and 3p21.3C regions harbor genes involved in the origin and/or development of CCs and imply that those genes might be multiple TSG(s)...
  43. ncbi Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus
    Bojana Panic
    MRC Laboratory of Molecular Biology, MRC Centre, Hills Road, Cambridge CB2 2QH, United Kingdom
    Mol Cell 12:863-74. 2003
    ..Despite no conservation of sequence, topology, or even helical direction, several other effectors form similar interactions with small GTPases via a pair of alpha helices, suggesting a common structural basis for effector recognition...
  44. pmc Giantin is the major Golgi autoantigen in human anti-Golgi complex sera
    Kazuhisa Nozawa
    Department of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA
    Arthritis Res Ther 6:R95-102. 2004
    ..The stable association of giantin with the putative released Golgi complex may contribute to its preferential autoantigenicity...
  45. pmc Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70
    Kai feng Xu
    Pulmonary Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:2784-9. 2005
    ..In cells incubated with brefeldin A, most of the BIG2, Exo70, and trans-Golgi protein p230 were widely dispersed from their perinuclear concentrations, but small amounts always remained, apparently at the ..
  46. ncbi Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells
    Claudia Zahn
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Mol Membr Biol 23:475-85. 2006
    ..These data suggest that lethality of Arfrp1 knockout embryos is due to a specific disruption of protein targeting, e.g., of ARL1 and Golgin-245, to the Golgi...
  47. ncbi The semantic component of the evoked potential of differentiation
    Chingis A Izmailov
    Moscow State University, Russia
    Span J Psychol 11:323-42. 2008
    ..is reflected in the occipital and temporal leads to an identical extent, but only in the amplitude of a later (N180-P230) component of the EPD...
  48. doi Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis
    Yasser El-Hawari
    Institute of Toxicology and Pharmacology for Natural Scientists, University Medical School Schleswig Holstein, Kiel, Germany
    Chem Biol Interact 178:234-41. 2009
    ..In particular, when nine residues (236-244) in the vicinity of the catalytic center and a proline (P230) in CBR3 were mutated to the corresponding residues of CBR1 a much higher k(cat)/K(m) value (5...
  49. doi Microtubule and katanin-dependent dynamics of microtubule nucleation complexes in the acentrosomal Arabidopsis cortical array
    Masayoshi Nakamura
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma 630 0192, Japan
    Nat Cell Biol 12:1064-70. 2010
    ..We visualized the dynamics of two fluorescently-tagged γ-tubulin complex proteins, GCP2 and GCP3, in Arabidopsis thaliana...
  50. pmc Arfaptins are localized to the trans-Golgi by interaction with Arl1, but not Arfs
    Zhiqiu Man
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    J Biol Chem 286:11569-78. 2011
    ..with Arl1 through their BAR domain-containing region and compete for Arl1 binding with golgin-97 and golgin-245/p230, both of which also bind to Arl1 through their GRIP (golgin-97/RanBP2/Imh1p/p230) domains...
  51. pmc Analysis of the human immunodeficiency virus type 1 M group Vpu domains involved in antagonizing tetherin
    Sarah J Petit
    MRC Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, Cruciform Building, 90 Gower Street, London WC1E 6BT, UK
    J Gen Virol 92:2937-48. 2011
    ..This work sheds light on the acquisition of anti-tetherin activity and the molecular details of pandemic HIV infection in humans...
  52. pmc Microtubule Reorganization during Mitosis and Cytokinesis: Lessons Learned from Developing Microgametophytes in Arabidopsis Thaliana
    Bo Liu
    Department of Plant Biology, University of California Davis, CA, USA
    Front Plant Sci 2:27. 2011
    ..However, a number of mutations like gem1, gcp2, and nedd1 can be maintained in heterozygous mutants in Arabidopsis thaliana...
  53. pmc Rab6a/a' are important Golgi regulators of pro-inflammatory TNF secretion in macrophages
    Massimo Micaroni
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    PLoS ONE 8:e57034. 2013
    ..In live cells, Rab6-GFP were localized on trans-Golgi network (TGN)-derived tubular carriers demarked by the golgin p230. Rab6 depletion and inactive mutants altered carrier egress and partially reduced p230 membrane association...
  54. pmc Activation of the γ-tubulin complex by the Mto1/2 complex
    Eric M Lynch
    Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Swann Building, Mayfield Road, Edinburgh EH9 3JR, UK
    Curr Biol 24:896-903. 2014
    ..microtubules in vivo, we further determine the number and stoichiometry of Mto1, Mto2, and γ-TuC subunits Alp4 (GCP2) and Alp6 (GCP3) within active nucleation complexes...
  55. pmc MicroRNA and mRNA cargo of extracellular vesicles from porcine adipose tissue-derived mesenchymal stem cells
    Alfonso Eirin
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States
    Gene 551:55-64. 2014
    ..These observations may contribute to development of regenerative strategies using EVs to overcome potential complications of cell-based therapy...
  56. doi Triesterase and promiscuous diesterase activities of a di-Co(II)-containing organophosphate degrading enzyme reaction mechanisms
    Marta E Alberto
    Dipartimento di Chimica e Tecnologie Chimiche and Centro di Calcolo ad Alte Prestazioni per Elaborazioni Parallele e Distribuite Centro d Eccellenza MIUR, Universita della Calabria, 87036 Arcavacata di Rende CS Italy
    Chemistry 21:3736-45. 2015
    ..phosphodiester by the di-Co(II) derivative of organophosphate degrading enzyme from Agrobacterium radiobacter P230(OpdA), have been investigated at density functional level of theory in the framework of the cluster model approach...
  57. doi Novel spectrophotometric methods for simultaneous determination of Amlodipine, Valsartan and Hydrochlorothiazide in their ternary mixture
    Hayam M Lotfy
    Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El Aini Street, 11562 Cairo, Egypt
    Spectrochim Acta A Mol Biomol Spectrosc 140:495-508. 2015
    ..applying successive derivative subtraction they were obtained in their first derivative spectra and determined at P230.8-246, P261.4-278.2, P233.7-246.8 for AML, HCT and VAL respectively...
  58. doi Molecular modeling reveals binding interface of γ-tubulin with GCP4 and interactions with noscapinoids
    Charu Suri
    Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, 173234, Himachal Pradesh, India
    Proteins 83:827-43. 2015
    ..e., GCP2, GCP3, GCP4, GCP5, and GCP6...
  59. ncbi Thin is better!: ultrathin cryosection immunocytochemistry
    Toshihiro Takizawa
    Department of Anatomy, Nippon Medical School, 1 1 5 Sendagi, Bunnkyo ku, Tokyo 113 8602, Japan
    J Nippon Med Sch 71:306-7. 2004
    ..Cryosections were incubated with mouse anti-p230, a trans-Golgi network marker, and subsequently incubated with Alexa 488-labeled goat anti-mouse IgG or with goat ..
  60. ncbi tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre
    Atsuko Yoshino
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6082, USA
    J Cell Sci 118:2279-93. 2005
    tGolgin-1 (trans-Golgi p230, golgin-245) is a member of a family of large peripheral membrane proteins that associate with the trans-Golgi network (TGN) via a C-terminal GRIP domain...
  61. ncbi Age-related differences in neuromagnetic brain activity underlying concurrent sound perception
    Claude Alain
    Rotman Research Institute, Baycrest Centre for Care, Toronto, Ontario, Canada M6A 2E1
    J Neurosci 27:1308-14. 2007
    ..140-180 ms) that overlapped the N1 and P2 waves, and a positive displacement that peaked at approximately 230 ms (P230) after sound onset...
  62. ncbi Leukemogenesis of b2a2-type p210 BCR/ABL in a bone marrow transplantation mouse model using a lentiviral vector
    Naoya Uchida
    Department of Molecular and Medical Genetics, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 76:134-47. 2009
    The BCR/ABL fusion oncogene found in Philadelphia-positive leukemia exists in three principle forms: p190, p210 and p230. P210 BCR/ABL is commonly found in patients with chronic myelogenous leukemia (CML) and is further categorized into ..
  63. doi Trans-Golgi protein p230/golgin-245 is involved in phagophore formation
    Miwa Sohda
    Division of Oral Biochemistry, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata 951 8514, Japan
    Biochem Biophys Res Commun 456:275-81. 2015
    b>p230/golgin-245 is a trans-Golgi coiled-coil protein that is known to participate in regulatory transport from the trans-Golgi network (TGN) to the cell surface...
  64. ncbi The GRIP domain - a novel Golgi-targeting domain found in several coiled-coil proteins
    S Munro
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH
    Curr Biol 9:377-80. 1999
    ..In this paper, we show that two other mammalian Golgi coiled-coil proteins, golgin-245/p230 and golgin-97, have a conserved domain of about 50 amino acids at their carboxyl termini...
  65. ncbi Effects of distraction on pain-related somatosensory evoked magnetic fields and potentials following painful electrical stimulation
    H Yamasaki
    Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan
    Brain Res Cogn Brain Res 9:165-75. 2000
    ..In the SEP recording, the middle-latency components (N140 and P230) were identified as being maximal around the vertex...
  66. ncbi Effect of glutamate carboxypeptidase II and reduced folate carrier polymorphisms on folate and total homocysteine concentrations in dialysis patients
    Manuela Fodinger
    Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Am Soc Nephrol 14:1314-9. 2003
    ..nucleotide polymorphisms in the reduced folate carrier 1 (RFC1 80G>A) and the glutamate carboxypeptidase 2 (GCP2 1561C>T) gene on total homocysteine (tHcy) plasma level and folate status in 120 chronic dialysis patients...
  67. ncbi The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure
    Merran C Derby
    Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, Victoria 3010, Australia, and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria 3010, Australia
    Traffic 8:758-73. 2007
    ..The TGN golgins, p230/golgin-245 and golgin-97, are recruited via the GTPase Arl1, whereas the TGN golgin GCC185 is recruited ..
  68. ncbi [Screening of proteins binding to FXR1P using yeast two-hybrid technique]
    Jiao Su
    Department of Biochemistry, Changzhi Medical College, Changzhi 046000, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:2394-6, 2400. 2009
    ..To screen the proteins interacting with FXR1P for functional investigation of FXR1P...
  69. pmc The {gamma}-tubulin complex protein GCP4 is required for organizing functional microtubule arrays in Arabidopsis thaliana
    Zhaosheng Kong
    Department of Plant Biology, University of California, Davis, California 95616, USA
    Plant Cell 22:191-204. 2010
    ..and organization depend on the evolutionarily conserved protein gamma -tubulin, which forms a complex with GCP2-GCP6 (GCP for gamma -Tubulin Complex Protein)...
  70. doi Clonal evolution with double Ph followed by tetraploidy in imatinib-treated chronic myeloid leukemia with e19a2 transcript in transformation
    Gaku Oshikawa
    Department of Hematology, Tokyo Medical and Dental University, Bunkyoku, Japan
    Cancer Genet Cytogenet 199:56-61. 2010
    Chronic myeloid leukemia (CML) with the e19a2 transcript coding for p230 is typically associated with a benign clinical course unless accompanied at presentation with additional chromosomal abnormalities...
  71. pmc CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex
    Yuk Kwan Choi
    Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, China
    J Cell Biol 191:1089-95. 2010
    ..TuRC bound to γ-TuNA contains NME7, FAM128A/B, and actin in addition to γ-tubulin and GCP2-6...
  72. pmc GTPase ARFRP1 is essential for normal hepatic glycogen storage and insulin-like growth factor 1 secretion
    Deike Hesse
    Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Mol Cell Biol 32:4363-74. 2012
    ..Our data indicate that ARFRP1 in the liver is involved in the regulation of IGF1 secretion and GLUT2 sorting and is thereby essential for normal growth and glycogen storage...
  73. doi Resistance of human butyrylcholinesterase to methylene blue-catalyzed photoinactivation; mass spectrometry analysis of oxidation products
    Ozden Tacal
    Department of Biochemistry, School of Pharmacy, Hacettepe University, Ankara, Turkey
    Photochem Photobiol 89:336-48. 2013
    ..412, 490, 522), oxidized methionine (M81, 144, 302, 532, 554, 555), oxidized histidine (H214), oxidized proline (P230), oxidized cysteine (C519) and oxidized serine (S215)...
  74. ncbi Bcr-Abl variants: biological and clinical aspects
    Anjali S Advani
    Departments of Hematology and Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Leuk Res 26:713-20. 2002
    ..Three different Bcr-Abl variants can be formed, depending on the amount of Bcr gene included: p185, p210, and p230. The three variants are associated with distinct types of human leukemias...
  75. ncbi Targeting of the GRIP domain to the trans-Golgi network is conserved from protists to animals
    Malcolm J McConville
    Russell Grimwade School of Biochemistry and Molecular Biology, University of Melbourne, Victoria, Australia
    Eur J Cell Biol 81:485-95. 2002
    ..GFP fusion proteins containing either the T. brucei GRIP domain or the human p230 GRIP (p230GRIP) domain were also expressed in the trypanosomatid parasite, Leishmania mexicana, and localized by ..
  76. ncbi Combination with an antisense oligonucleotide synergistically improves the antileukemic efficacy of erucylphospho-N,N,N-trimethylpropylammonium in chronic myeloid leukemia cell lines
    Spiro M Konstantinov
    Unit of Toxicology and Chemotherapy, German Cancer Research Center, 69120 Heidelberg, Germany
    Mol Cancer Ther 1:877-84. 2002
    ..01). AR-230 cells that express high levels of p230(BCR-ABL) showed an intermediate decrease in colony formation in response to the ASO-bcr (T/C%, 20; P < 0.05)...
  77. ncbi Autoantibodies to protein transport and messenger RNA processing pathways: endosomes, lysosomes, Golgi complex, proteasomes, assemblyosomes, exosomes, and GW bodies
    Laura M Stinton
    Faculty of Medicine, University of Calgary, Calgary, AB, Canada
    Clin Immunol 110:30-44. 2004
    ..Current evidence suggests that GWBs are involved in the cytoplasmic processing of mRNAs. Autoantibodies to the "cytoplasmic somes" are relatively uncommon and serological tests to detect most of them are not widely available...
  78. pmc Characterization of the different BCR-ABL transcripts with a single multiplex RT-PCR
    Jacques Chasseriau
    Laboratoire de Genetique Cellulaire et Moleculaire, UPRES EA2622, Poitiers Cedex, France
    J Mol Diagn 6:343-7. 2004
    ..Identification of the transcript (p190, p210 or p230) does not reveal the type of junction but this information is very important for classification of patients in ..
  79. ncbi Antiangiogenic gene therapy of myeloproliferative disease developed in transgenic mice expressing P230 bcr/abl
    K Miyake
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan
    Gene Ther 12:541-5. 2005
    ..We have recently produced transgenic mice expressing P230 bcr/abl that develop myeloproliferative disease (MPD) closely resembling human chronic myelogenous leukemia...
  80. pmc Effects of {gamma}-tubulin complex proteins on microtubule nucleation and catastrophe in fission yeast
    Sabina Zimmerman
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Mol Biol Cell 16:2719-33. 2005
    ..Here, we investigated gamma-TuC function by analyzing MT behavior in mto1Delta and alp4 (GCP2 homologue) mutants...
  81. ncbi N-substituted 4-aminobenzamides (procainamide analogs): an assessment of multiple cellular effects concerning ion trapping
    Guillaume Morissette
    Centre de Recherche en Rhumatologie et Immunologie, Centre Hospitalier Universitaire de Quebec, 2705 Laurier Blvd, Quebec, QC, Canada G1V 4G2
    Mol Pharmacol 68:1576-89. 2005
    ..Giant vacuole formation, of confirmed trans-Golgi origin (labeled with C5-ceramide, p230, golgin-97), is a cellular response to all tested amines in the series (> or = 2.5 mM), including triethylamine...
  82. pmc Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes
    Kirika Nishimoto-Morita
    Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 284:10583-92. 2009
    ..Furthermore, we have obtained evidence suggesting that a SNARE complex containing Vti1a, syntaxin 6, and syntaxin 16 is involved in Shiga toxin transport downstream of ARL1...
  83. doi Functional replacement of fission yeast γ-tubulin small complex proteins Alp4 and Alp6 by human GCP2 and GCP3
    Timothy D Riehlman
    College of Nanoscale Science and Engineering, State University of New York SUNY, Nanobioscience, Albany, NY12203, USA
    J Cell Sci 126:4406-13. 2013
    ..that GCP3/Spc98 function is fully conserved with Alp6 across species but that functional differences exist between GCP2/Spc97 and Alp4...
  84. doi Arabidopsis GCP3-interacting protein 1/MOZART 1 is an integral component of the γ-tubulin-containing microtubule nucleating complex
    Masayoshi Nakamura
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0192, Japan
    Plant J 71:216-25. 2012
    ..a pattern largely consistent with, but partly distinct from, the localization of the γ-tubulin complex containing GCP2 or GCP3 in planta...
  85. pmc The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium
    Alexander Jaschke
    Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam Rehbruecke, D 14558 Nuthetal, Germany
    Hum Mol Genet 21:3128-42. 2012
    ..Thus, the GTPase ARFRP1 and its downstream proteins are required for the lipidation of chylo-microns and the assembly of ApoA-I to these particles in the Golgi of intestinal epithelial cells...
  86. doi Prenatal stress alters dendritic morphology and synaptic connectivity in the prefrontal cortex and hippocampus of developing offspring
    Richelle Mychasiuk
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada
    Synapse 66:308-14. 2012
    The current study used stereological techniques in combination with Golg-Cox methods to examine the neuroanatomical alterations in the prefrontal cortex and hippocampus of developing offspring exposed to gestational stress...
  87. ncbi Molecular cloning of Drosophila TFIID subunits
    T Kokubo
    National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    Nature 367:484-7. 1994
    ..Thus, TAFs are essential cofactors for regulated transcription. The complementary DNAs encoding the p230 (M(r) 230,000), p110 and p85 subunits of TFIID have recently been cloned...
  88. ncbi Apoptosis is induced in BHK cells by the tsBN462/13 mutation in the CCG1/TAFII250 subunit of the TFIID basal transcription factor
    T Sekiguchi
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Exp Cell Res 218:490-8. 1995
    ..golden hamsters, tsBN462 has a mutation in the gene encoding the largest subunit of the TFIID complex, TAFII250/p230/CCG1, and arrests in the G1 phase at the nonpermissive temperature, 39.5 degrees C...
  89. pmc The Drosophila 110-kDa transcription factor TFIID subunit directly interacts with the N-terminal region of the 230-kDa subunit
    T Kokubo
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:5896-900. 1993
    ..protein expressed in Sf9 cells via a baculovirus vector interacts directly with the 230-kDa subunit of TFIID (p230)...
  90. ncbi Drosophila 230-kD TFIID subunit, a functional homolog of the human cell cycle gene product, negatively regulates DNA binding of the TATA box-binding subunit of TFIID
    T Kokubo
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    Genes Dev 7:1033-46. 1993
    A Drosophila cDNA encoding the largest TFIID subunit (p230) was isolated using a degenerate oligodeoxynucleotide probe based on an amino acid sequence of the purified protein...
  91. ncbi Molecular characterization of Golgin-245, a novel Golgi complex protein containing a granin signature
    M J Fritzler
    Department of Medical Biochemistry, University of Calgary, Alberta, Canada
    J Biol Chem 270:31262-8. 1995
    ..This is the first report of a Golgi complex autoantigen that bears structural similarities to the granin family of proteins...
  92. ncbi p230 is associated with vesicles budding from the trans-Golgi network
    P A Gleeson
    Department of Pathology and Immunology, Monash University Medical School, Melbourne, Victoria, Australia
    J Cell Sci 109:2811-21. 1996
    ..We have previously described a brefeldin-A sensitive, hydrophilic protein (p230), containing a very high frequency of heptad repeats, found in the cytosol and associated with Golgi membranes...
  93. ncbi Purification and characterization of a DNA binding protein in a nuclear scaffold fraction from rat ascites hepatoma cells
    Y Hibino
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama City, Japan
    Carcinogenesis 18:707-13. 1997
    ..affinities of highly repetitive DNA components for a nuclear scaffold protein from rat ascites hepatoma cells (P230) depend on the degree of sequence-directed bending of the helix axis...
  94. ncbi TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family
    J Nakayama
    Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
    Cell 88:875-84. 1997
    ..The cDNA encodes a 2629 amino acid sequence and produces the TLP1 proteins p240 and p230. The anti-TLP1 antibody specifically immunoprecipitated the telomerase activity...
  95. ncbi Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell line
    S Ishikawa
    Laboratory of Molecular Medicine, University of Tokyo, Japan
    DNA Res 4:35-43. 1997
    ..segment was 638,489 bp, in which we identified only four genes including the integrin alpha RLC and the trans-Golgi p230 genes, both reported previously...
  96. ncbi Visual evoked potentials relating to imagery: words for concrete objects versus absolute concepts
    I Shimoyama
    Department of Physiology, School of Medicine, Chiba University, Japan
    Brain Topogr 9:271-4. 1997
    ..by multivariate analysis of variance (MANOVA) and comparison of topographies at four remarkable peaks (P110, N160, P230 and N320). MANOVA showed significant differences (p < 0...
  97. ncbi Isolation and characterization of a 230 kDa protein (p230) specifically expressed in fetal brains: its involvement in neurite outgrowth from rat cerebral cortex neurons grown on monolayer of astrocytes
    S Wakatsuki
    Department of Biotechnology, The University of Tokyo
    J Biochem 122:1146-52. 1997
    ..against growth cone membrane fraction from fetal porcine brains, we have identified a 230 kDa antigen, termed p230. Western blot analysis of extracts from various tissues demonstrated that p230 is specifically expressed in brains, ..
  98. ncbi Characterization of a 1200-kb genomic segment of chromosome 3p22-p21.3
    Y Daigo
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan
    DNA Res 6:37-44. 1999
    ..The other gene F56 revealed no significant homology to any known genes. These results disclosed complete physical and transcriptional maps of the 1200-kb region of 3p present in YAC 936c1...
  99. pmc The fission yeast gamma-tubulin complex is required in G(1) phase and is a component of the spindle assembly checkpoint
    L Vardy
    Laboratory of Cell Regulation, Imperial Cancer Research Fund, PO Box 123, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    EMBO J 19:6098-111. 2000
    ..Spc97/Hs.Gcp2 and Sc. Spc98/Hs.Gcp3, respectively...
  100. ncbi Phosphatidyl inositol signaling by BCR/ABL: opportunities for drug development
    J D Griffin
    Leukemia Program, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Chemother Pharmacol 48:S11-6. 2001
    ..on chromosome 22, resulting in the production of one or more of a family of chimeric oncoproteins, p190, p210, or p230 BCR/ABL...
  101. pmc GCP5 and GCP6: two new members of the human gamma-tubulin complex
    S M Murphy
    Department of Biological Sciences, Stanford University, Stanford, California 94305 5020, USA
    Mol Biol Cell 12:3340-52. 2001
    ..Stoichiometry experiments revealed that there is a single copy of GCP5 and multiple copies of gamma-tubulin, GCP2, GCP3, and GCP4 within the gamma-tubulin complex...

Research Grants9

  1. Kim C Williamson; Fiscal Year: 2014
    ..Pfs48/45 is one of four Plasmodium proteins (Pfs48/45 and P230, P25 and P28) that are the targets of monoclonal antibodies that effectively block malaria Tx and have been ..
  2. ROLE OF CHEMOKINES IN T CELL MEDIATED COLITIS
    James Lillard; Fiscal Year: 2002
    ..The second aim will assess the role of mIL-8Rh (murine IL- 8/GCP2 receptor), CCR5 (a RANTES receptor), CXCR3, and XCRl (Lptn receptor) interactions in the CD45RBHI CD4+ T cell ..
  3. ANTI-GAL IGG ON HUMAN RED CELLS: A MODEL FOR CELL AGING
    Uri Galili; Fiscal Year: 1993
    ..was found to result from diminished activity of the enzyme, alpha1>3 galactosyltransferase, which, in the Golg: apparatus, catalyzes the following reaction: Galbeta1>4GlcNAc-R + UDP- Gal>Gal alpha1>3Gal beta1>..
  4. BCR/ABL SIGNALING IN HUMAN LEUKEMIAS
    Ann Marie Pendergast; Fiscal Year: 2003
    ..P185 which is associated with a subset of acute lymphocytic leukemias (ALL), and P230 which is associated with chronic neutrophilic leukemia (CNL), a rare myeloproliferative disorder characterized by a ..
  5. APPLIED BISYSTEMS PRISM 3100 GENETIC ANALYZER
    Edward Chan; Fiscal Year: 2002
    ..This instrument will be an important asset to serve well in furthering the progress of many NIH- funded research in the MEM Department and the proposed RDCC. ..
  6. GOLGI COMPLEX ANTIBODIES AND AUTOANTIGENS
    Edward Chan; Fiscal Year: 2004
    ..It is anticipated that testing of the P.I.'s hypotheses will provide new insights into autoimmunity and autoimmune diseases associated with subcellular organelles. ..
  7. International Workshop on Autoantibodies & Autoimmunity
    Edward Chan; Fiscal Year: 2005
    ..abstract_text> ..
  8. GLUCOCORTICOID ATTENUATED RESPONSE GENES IN INFLAMMATION
    Jeffrey Smith; Fiscal Year: 2001
    ..Genes identified in this search are likely to encode pro-inflammatory mediators that participate in a wide range of inflammatory lung diseases in addition to endotoxemia. ..
  9. Regulation of Hematopoiesis by Notch Receptors
    James Griffin; Fiscal Year: 2007
    ..abstract_text> ..