p21

Summary

Gene Symbol: p21
Description: cyclin dependent kinase inhibitor 1A
Alias: CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, CDK-interaction protein 1, DNA synthesis inhibitor, cyclin-dependent kinase inhibitor 1A (p21, Cip1), melanoma differentiation associated protein 6, wild-type p53-activated fragment 1
Species: human

Top Publications

  1. ncbi WAF1, a potential mediator of p53 tumor suppression
    W S El-Deiry
    Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231
    Cell 75:817-25. 1993
  2. ncbi Requirement for p53 and p21 to sustain G2 arrest after DNA damage
    F Bunz
    The Howard Hughes Medical Institute and The Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 282:1497-501. 1998
  3. ncbi New functional activities for the p21 family of CDK inhibitors
    J LaBaer
    Massachusetts General Hospital Cancer Center, Charlestown 02129, USA
    Genes Dev 11:847-62. 1997
  4. ncbi The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    J W Harper
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030
    Cell 75:805-16. 1993
  5. pmc Stress- and Rho-activated ZO-1-associated nucleic acid binding protein binding to p21 mRNA mediates stabilization, translation, and cell survival
    Mei Nie
    Department of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Proc Natl Acad Sci U S A 109:10897-902. 2012
  6. pmc CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation
    Hideo Nishitani
    Graduate School of Life Science, University of Hyogo, Kamigori, Ako gun, Hyogo, 678 1297, Japan
    J Biol Chem 283:29045-52. 2008
  7. pmc The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing
    Youngjo Kim
    Department of Cellular Biology, University of Georgia, Athens, Georgia 30602 USA
    Genes Dev 22:2507-19. 2008
  8. pmc Gene polymorphisms of cellular senescence marker p21 and disease progression in non-alcohol-related fatty liver disease
    Aloysious Aravinthan
    Department of Medicine University of Cambridge Cambridge, UK
    Cell Cycle 13:1489-94. 2014
  9. ncbi HIV-1 Vpr activates cell cycle inhibitor p21/Waf1/Cip1: a potential mechanism of G2/M cell cycle arrest
    Iqbal H Chowdhury
    Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville 20850, USA
    Virology 305:371-7. 2003
  10. pmc p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway
    Awatef Allouch
    Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 75015 Paris, France
    Proc Natl Acad Sci U S A 110:E3997-4006. 2013

Research Grants

  1. Deregulated lipid metabolism in stroke
    Robert J Dempsey; Fiscal Year: 2013
  2. Fiona Simpkins; Fiscal Year: 2016
  3. Michele Pagano; Fiscal Year: 2016
  4. Mark S Ledoux; Fiscal Year: 2016
  5. Role of p53 in cell cycle checkpoints
    James J Manfredi; Fiscal Year: 2013
  6. CBP Bromodomain Antagonists Block Androgen Receptor in Prostate Cancer
    SYED S MUJTABA; Fiscal Year: 2010
  7. The Role of HNF4alpha in Cell Proliferation
    Linh Vuong; Fiscal Year: 2013
  8. Edward T Kipreos; Fiscal Year: 2015
  9. Cux-1 and cell cycle regulation in kidney development
    Gregory Vanden Heuvel; Fiscal Year: 2009
  10. Chou Zen Giam; Fiscal Year: 2014

Detail Information

Publications346 found, 100 shown here

  1. ncbi WAF1, a potential mediator of p53 tumor suppression
    W S El-Deiry
    Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231
    Cell 75:817-25. 1993
    ..Using a subtractive hybridization approach, we identified a gene, named WAF1, whose induction was associated with wild-type but not mutant p53 gene expression in a human brain tumor cell line...
  2. ncbi Requirement for p53 and p21 to sustain G2 arrest after DNA damage
    F Bunz
    The Howard Hughes Medical Institute and The Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
    Science 282:1497-501. 1998
    ..when p53 was present in the cell and capable of transcriptionally activating the cyclin-dependent kinase inhibitor p21. After disruption of either the p53 or the p21 gene, gamma radiated cells progressed into mitosis and exhibited a ..
  3. ncbi New functional activities for the p21 family of CDK inhibitors
    J LaBaer
    Massachusetts General Hospital Cancer Center, Charlestown 02129, USA
    Genes Dev 11:847-62. 1997
    ..In this report we demonstrate that the CDK inhibitors p21(CIP), p27(KIP), and p57(KIP2) all promote the association of cdk4 with the D-type cyclins...
  4. ncbi The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    J W Harper
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030
    Cell 75:805-16. 1993
    ..CIP1 encodes a novel 21 kd protein that is found in cyclin A, cyclin D1, cyclin E, and Cdk2 immunoprecipitates. p21CIP1 is a potent, tight-binding inhibitor of Cdks and can inhibit the phosphorylation of Rb by cyclin A-Cdk2, cyclin E-..
  5. pmc Stress- and Rho-activated ZO-1-associated nucleic acid binding protein binding to p21 mRNA mediates stabilization, translation, and cell survival
    Mei Nie
    Department of Cell Biology, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    Proc Natl Acad Sci U S A 109:10897-902. 2012
    A central component of the cellular stress response is p21(WAF1/CIP1), which regulates cell proliferation, survival, and differentiation...
  6. pmc CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation
    Hideo Nishitani
    Graduate School of Life Science, University of Hyogo, Kamigori, Ako gun, Hyogo, 678 1297, Japan
    J Biol Chem 283:29045-52. 2008
    ..The CDK inhibitor p21, another PCNA-binding protein, is also degraded both in S phase and after UV irradiation...
  7. pmc The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing
    Youngjo Kim
    Department of Cellular Biology, University of Georgia, Athens, Georgia 30602 USA
    Genes Dev 22:2507-19. 2008
    ..elegans and humans by targeting the degradation of the cyclin-dependent kinase (CDK) inhibitors CKI-1 and p21(Cip1), respectively...
  8. pmc Gene polymorphisms of cellular senescence marker p21 and disease progression in non-alcohol-related fatty liver disease
    Aloysious Aravinthan
    Department of Medicine University of Cambridge Cambridge, UK
    Cell Cycle 13:1489-94. 2014
    ..Previous studies have demonstrated an association between hepatocyte p21 expression and fibrosis stage in NAFLD...
  9. ncbi HIV-1 Vpr activates cell cycle inhibitor p21/Waf1/Cip1: a potential mechanism of G2/M cell cycle arrest
    Iqbal H Chowdhury
    Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville 20850, USA
    Virology 305:371-7. 2003
    ..evidence that Vpr activates the expression and transcription of the cyclin-dependent kinase inhibitor p21/Waf1/Cip1 (hereafter p21), an inhibitor of the G1 and G2/M phase transitions in T lymphoid and myeloid cells...
  10. pmc p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway
    Awatef Allouch
    Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 75015 Paris, France
    Proc Natl Acad Sci U S A 110:E3997-4006. 2013
    ..We have previously shown that the cyclin-dependent kinase inhibitor p21 inhibits the replication of HIV-1 and other primate lentiviruses in human monocyte-derived macrophages by impairing ..
  11. pmc Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"
    Laurence Bockstaele
    Institute of Interdisciplinary Research, Universite Libre de Bruxelles, Campus Erasme, B 1070 Brussels, Belgium
    Mol Cell Biol 26:5070-85. 2006
    ..Thr172-phosphorylated CDK4 was enriched in complexes containing p21 or p27, even at inhibitory levels of p27 that precluded CDK4 activity...
  12. doi Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21
    Naoto Tsuchiya
    Division of Cancer Development System and Cancer Differentiation, National Cancer Center Research Institute, Tsukiji, Japan
    Cancer Res 71:4628-39. 2011
    ..miR-22 as a p53 target gene that selectively determines the induction of p53-dependent apoptosis by repressing p21. Combinatorial analyses of the AGO2 immunocomplex and gene expression profiles identified p21 as a direct target of ..
  13. doi MYC accelerates p21CIP-induced megakaryocytic differentiation involving early mitosis arrest in leukemia cells
    Maria J Munoz-Alonso
    Departamento de Biologia Molecular, Universidad de Cantabria, Santander, Spain
    J Cell Physiol 227:2069-78. 2012
    b>p21(CIP) is a potent cell cycle inhibitor often up-regulated in differentiation. Protooncogene MYC induces cell growth and proliferation, inhibits differentiation and represses p21(CIP)...
  14. pmc Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest
    Shelly A Waggoner
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:9039-49. 2009
    ..Targeted analysis of genes involved in cell cycle control revealed a marked increase in p21(WAF) mRNA and protein...
  15. pmc Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21
    Yuefeng Wang
    Departments of Structural Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Chem Biol 7:214-21. 2011
    ..the physical basis of IDP binding diversity and report here that the cyclin-dependent kinase (Cdk) inhibitor p21(Cip1) adaptively binds to and inhibits the various Cdk-cyclin complexes that regulate eukaryotic cell division...
  16. doi Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance
    Andrew J Vincent
    Mitchell Cancer Institute, University of South Alabama, Mobile, AL, United States
    FEBS Lett 586:3429-34. 2012
    ..that NUPR1 functions as a transcriptional cofactor for the p300-p53 complex and transcriptionally regulates p21 expression...
  17. ncbi The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
    S Waga
    Cold Spring Harbor Laboratory, New York 11724
    Nature 369:574-8. 1994
    The p53 tumour-suppressor protein controls the expression of a gene encoding the p21 cyclin-dependent protein kinase (CDK) regulator...
  18. ncbi p53-dependent down-regulation of telomerase is mediated by p21waf1
    Igor Shats
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 279:50976-85. 2004
    ..Knockdown of the key p53 transcriptional target, p21, was sufficient to eliminate the p53-dependent repression of hTERT...
  19. ncbi Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells
    Yung Kang Lee
    Departments of Molecular Pharmacology and Toxicology, Norris Cancer Center, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 282:1595-606. 2007
    ..We then present evidence that Dox-mediated induction of cell cycle regulator p21 expression is differentially regulated by KAP1 sumoylation status...
  20. pmc MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression
    Irena Ivanovska
    Rosetta Inpharmatics LLC, 401 Terry Ave N, Seattle, WA 98109, USA
    Mol Cell Biol 28:2167-74. 2008
    ..Microarray profiling uncovers multiple targets of the family, including the cyclin-dependent kinase inhibitor p21/CDKN1A...
  21. pmc Feedback between p21 and reactive oxygen production is necessary for cell senescence
    Joao F Passos
    Ageing Research Laboratories, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Mol Syst Biol 6:347. 2010
    ..The essential feature of the loop is that long-term activation of the checkpoint gene CDKN1A (p21) induces mitochondrial dysfunction and production of reactive oxygen species (ROS) through serial signalling ..
  22. doi Suppression of Polo like kinase 1 (PLK1) by p21(Waf1) mediates the p53-dependent prevention of caspase-independent mitotic death
    Yi Cheng Lin
    Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei, 11221, Taiwan
    Cell Signal 23:1816-23. 2011
    Polo-like kinase 1 (Plk1) plays key roles in many aspects of mitosis. We have previously shown that induction of p21(Waf1) by p53 is responsible for protection of cells against adriamycin-induced polyploidy formation and mitotic ..
  23. doi Inhibition of SIRT1 by HIV-1 viral protein Tat results in activation of p53 pathway
    Basant Kumar Thakur
    Department of Pediatrics Hematology and Oncology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Biochem Biophys Res Commun 424:245-50. 2012
    ..both the deacetylase and promoter activity of SIRT1, (2) SIRT1 inhibition by Tat involves increased levels of acetylated p53 and (3) The activation of p53 leads to subsequent increases in the expression of p53 target genes, p21 and BAX.
  24. pmc Analysis of wild-type and mutant p21WAF-1 gene activities
    J Lin
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Mol Cell Biol 16:1786-93. 1996
    ..The p21WAF-1 binding sites for cyclins (residues 21 to 26), cdk2 (residues 49 to 71), and proliferating-cell nuclear antigen (residues 124 to 164) have all been mapped to discrete sites on the protein...
  25. ncbi Cdk2-dependent Inhibition of p21 stability via a C-terminal cyclin-binding motif
    Hongyan Zhu
    Department of Radiation and Cellular Oncology, Center for Molecular Oncology, University of Chicago, Chicago, IL 60637, USA
    J Biol Chem 280:29282-8. 2005
    b>p21 is a member of the Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors that includes p21, p27, and p57...
  26. pmc Cyclin-binding motifs are essential for the function of p21CIP1
    J Chen
    Department of Pathology, Division of Molecular Oncology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 16:4673-82. 1996
    The cyclin-dependent kinase (Cdk) inhibitor p21 is induced by the tumor suppressor p53 and is required for the G1-S block in cells with DNA damage...
  27. doi Involvement of p21waf1/cip1 expression in the cytotoxicity of the potent histone deacetylase inhibitor spiruchostatin B towards susceptible NALM-6 human B cell leukemia cells
    Syu ichi Kanno
    Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University, Aoba ku, Sendai 981 8558, Japan
    Int J Oncol 40:1391-6. 2012
    ..NALM-6 has higher endogenous p21waf1/cip1 mRNA expression than other leukemia cells...
  28. ncbi Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients
    Weiya Xia
    Departments of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 10:3815-24. 2004
    The diversity of biological functions makes p21(Cip1/WAF1) (p21) a controversial marker in predicting the prognosis of breast cancer patients...
  29. pmc LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest
    Jennifer P Morton
    Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Gastroenterology 139:586-97, 597.e1-6. 2010
    ..In this study, we aimed to investigate the impact of LKB1 down-regulation for pancreatic cancer in mouse and human and to elucidate the mechanism by which Lkb1 deregulation contributes to this disease...
  30. ncbi Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage
    Joan Seoane
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nature 419:729-34. 2002
    ..effect of p53 is mediated by transcriptional activation of the cyclin-dependent kinase (CDK) inhibitor p21(Cip1), whereas the apoptotic effect is mediated by transcriptional activation of mediators including PUMA and PIG3 (ref...
  31. ncbi Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells
    Zhi Min Liu
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong
    Oncogene 23:503-13. 2004
    Both heme oxygenase-1 (HO-1) and p21(WAF1/Cip1) (p21) are involved in the pathogenesis of human cancer and their functions are closely associated with apoptosis...
  32. pmc Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability
    Hauke Cornils
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Mol Cell Biol 31:1382-95. 2011
    ..Our findings suggest that NDR kinases control protein stability of the cyclin-Cdk inhibitor protein p21 by direct phosphorylation...
  33. doi Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation
    Michael D Howell
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Invest Dermatol 128:2248-58. 2008
    ..Interference of S100/A11 expression, by siRNA, inhibited induction of HBD-3 and FLG. Furthermore p21, a cyclin-dependent kinase inhibitor downstream of S100/A11, was required for calcium-mediated induction of HBD-3 ..
  34. ncbi p21/CDKN1A mediates negative regulation of transcription by p53
    Kristina Löhr
    Institut fur Virologie, Philipps Universitat Marburg, Robert Koch str 17, 35037 Marburg, Germany
    J Biol Chem 278:32507-16. 2003
    ..Strikingly, when the p53-inducible p21/CDKN1A gene was deleted, p53 no longer repressed any one among 11 genes that it down-regulates otherwise...
  35. ncbi Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1
    John B Bruning
    Department of Biochemistry and Cell Biology, Rice University, 6100 South Main Street, MS140, Houston, TX 77005, USA
    Structure 12:2209-19. 2004
    ..that the pol-delta p66 and FEN1 peptides interact with hPCNA at the same site shown to bind the cdk-inhibitor p21(CIP1)...
  36. pmc PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
    Tarek Abbas
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
    Genes Dev 22:2496-506. 2008
    ..Here we demonstrate that PCNA promotes the ubiquitylation and degradation of the CDK inhibitor p21 in cells irradiated with low dose of ultraviolet (UV) by a similar mechanism...
  37. pmc Human cytomegalovirus pUL29/28 and pUL38 repression of p53-regulated p21CIP1 and caspase 1 promoters during infection
    John P Savaryn
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    J Virol 87:2463-74. 2013
    ..HCMV pUL29/28 with pUL38 altered the activity of the 53-regulatable p21CIP1 promoter...
  38. ncbi A single nucleotide substitution at codon 31 (Ser/Arg) defines a polymorphism in a highly conserved region of the p53-inducible gene WAF1/CIP1
    M Chedid
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892
    Oncogene 9:3021-4. 1994
    The recently discovered WAF1/CIP1 gene is a mediator of p53 tumor suppressor activity. To analyse WAF1/CIP1 for possible mutations, polymerase chain reaction (PCR) amplified cDNAs from several tumor cell lines were cloned and sequenced...
  39. ncbi Differential modulation of paclitaxel-mediated apoptosis by p21Waf1 and p27Kip1
    M Schmidt
    Department of Experimental Therapeutics, Division of Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, TX 77030, USA
    Oncogene 19:2423-9. 2000
    ....
  40. pmc Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck
    Zhongqiu Wang
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer 11:17. 2012
    Cell cycle deregulation is common in human cancer, and alterations of p27 and p21, two critical cell cycle regulators, have been implicated in the development of many human malignancies...
  41. ncbi PKCeta associates with cyclin E/cdk2/p21 complex, phosphorylates p21 and inhibits cdk2 kinase in keratinocytes
    M Kashiwagi
    Institute of Molecular Oncology, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Oncogene 19:6334-41. 2000
    ..We provide here another function of PKC, namely, regulating cell cycle by interaction with the cyclin E/cdk2/p21 complex...
  42. pmc EBNA3C augments Pim-1 mediated phosphorylation and degradation of p21 to promote B-cell proliferation
    Shuvomoy Banerjee
    Department of Microbiology and the Tumor Virology Program, Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Pathog 10:e1004304. 2014
    ..cell proliferation by altering Pim-1 mediated regulation of the activity of the cell-cycle inhibitor p21/WAF1. Our study demonstrated that EBNA3C significantly induces Pim-1 mediated proteosomal degradation of p21...
  43. ncbi Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1
    Adriana De Siervi
    Molecular Therapeutics Unit, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 64:743-50. 2004
    ..We have shown previously that perifosine induces p21(waf1/cip1) in a p53-independent fashion and that induction of p21(waf1/cip1) is required for the perifosine-induced cell ..
  44. doi Inhibiting enhancer of zeste homolog 2 promotes cellular senescence in gastric cancer cells SGC-7901 by activation of p21 and p16
    Jie Bai
    Department of Gastrointestinal Surgery II, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei Province, People s Republic of China
    DNA Cell Biol 33:337-44. 2014
    ..To prove that EZH2 expression contributes substantially to the change of key cell cycle regulators, we showed that p21 and p16 were activated to a certain extent upon EZH2 depletion and activation of p21 was in a p53-independent ..
  45. ncbi Modulation of cell cycle control by vitamin D3 and its analogue, EB1089, in human breast cancer cells
    G Wu
    Department of Biochemistry and Molecular Biology, Medical College of Ohio, Toledo 43699 0008, USA
    Oncogene 15:1555-63. 1997
    ..in MCF-7 E cells showed that after EB1089 treatment, there was a concentration and time dependent up-regulation of p21 as well as a decrease in cyclin A proteins...
  46. doi P21 codon 31 polymorphism associated with cancer among white people: evidence from a meta-analysis involving 78,074 subjects
    Fei Liu
    Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, 37 Guo Xue Road, Chengdu 610041, Sichuan Province, China
    Mutagenesis 26:513-21. 2011
    b>p21 protein is a cell cycle regulator that induces G1 arrest, leading to DNA repair or apoptosis. Previous studies have shown that p21 polymorphism in codon 31 (Ser 31 Arg) may play a role in susceptibility to cancer...
  47. pmc Association of p21 SNPs and risk of cervical cancer among Chinese women
    Ning Wang
    Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
    BMC Cancer 12:589. 2012
    The p21 codon 31 single nucleotide polymorphism (SNP), rs1801270, has been linked to cervical cancer but with controversial results...
  48. ncbi Reversible phosphorylation at the C-terminal regulatory domain of p21(Waf1/Cip1) modulates proliferating cell nuclear antigen binding
    M T Scott
    Cancer Research Campaign Laboratories, University of Dundee Medical School, Dundee DD1 9SY, United Kingdom
    J Biol Chem 275:11529-37. 2000
    The p53-inducible gene product p21(WAF1/CIP1) plays a critical role in regulating the rate of tumor incidence, and identifying mechanisms of its post-translational regulation will define key pathways that link growth control to p21-..
  49. doi P21 (waf1/cip1) is required for non-small cell lung cancer sensitive to Gefitinib treatment
    Yi Fan Zhao
    Laboratory of Cancer Research, Tongji University School of Medicine, Shanghai 200092, China
    Biomed Pharmacother 65:151-6. 2011
    ..Here, we show that Gefitinib reduces p-Akt levels, concomitant with elevation of p21 levels and suppression of cdk2/4 and cyclinE/D1 activities which result in impaired cell cycle progression through ..
  50. doi Hepatitis B virus X induces cell proliferation in the hepatocarcinogenesis via up-regulation of cytoplasmic p21 expression
    Masahiko Yano
    Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences Niigata University, Niigata, Japan
    Liver Int 33:1218-29. 2013
    ..Cyclin-dependent kinase inhibitor p21 (Cip1/WAF1), known as a tumour-suppressor gene, has been reported to have paradoxical function, that is, acting as an ..
  51. ncbi Inhibition of cell growth by transforming growth factor beta 1 is associated with p53-independent induction of p21 in gastric carcinoma cells
    M Akagi
    First Department of Pathology, Hiroshima University School of Medicine, Japan
    Jpn J Cancer Res 87:377-84. 1996
    ..SDI1/CIP1/WAF1/p21 is a potent inhibitor of G1 cdks, whose expression is induced by wild-type p53...
  52. ncbi IGF-1 activates p21 to inhibit UV-induced cell death
    Stephen A Murray
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 20118, USA
    Oncogene 22:1703-11. 2003
    ..In this study, we show that IGF-1 activates p21 protein expression in a p53-dependent manner...
  53. ncbi Relation between HPV-DNA and expression of p53, bcl-2, p21WAF-1, MIB-1, HER-2/neu and DNA ploidy in early cervical carcinoma: correlation with clinical outcome
    M Graflund
    Department of Gynecological Oncology, Orebro University Hospital, SE 701 85 Orebro, Sweden
    Oncol Rep 12:169-76. 2004
    ..In conclusion, the HPV DNA subtype was a prognostic factor in early stage cervical cancer and it was associated with age, positive lymph nodes, tumor size, DNA ploidy and the proliferation marker MIB-1...
  54. pmc Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53
    David Dornan
    CRUK Interferon and Cell Signalling Group, Cell Signalling Unit, Cancer Research Centre, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, United Kingdom
    Mol Cell Biol 24:10083-98. 2004
    ..distinct sets of downstream genes; however, these two antioncogenic transcription factors converge to regulate p21 gene expression and to inhibit tumor formation...
  55. pmc A polymorphism at codon 31 of gene p21 is not associated with primary open angle glaucoma in Caucasians
    Thomas Ressiniotis
    Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    BMC Ophthalmol 5:5. 2005
    ..b>p21, is an important protective component of the apoptotic pathway, regulating cellular arrest in the presence of DNA ..
  56. doi p53-, SIRT1-, and PARP-1-independent downregulation of p21WAF1 expression in nicotinamide-treated cells
    Hyung Il Lee
    Department of Life Science, University of Seoul, Dongdaemungu, Jeonnongdong 90, Seoul 130 743, Republic of Korea
    Biochem Biophys Res Commun 368:298-304. 2008
    ..Our results indicate that nicotinamide treatment attenuates p21WAF1 expression through Sp1 downregulation, and suggest a possible involvement of nicotinamide metabolism in cellular gene expression...
  57. pmc Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response
    Weimin Chen
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85721, USA
    Mol Cell 34:663-73. 2009
    In response to oxidative stress, Nrf2 and p21(Cip1/WAF1) are both upregulated to protect cells from oxidative damage...
  58. doi Lactococcus lactis ssp. lactis inhibits the proliferation of SNU-1 human stomach cancer cells through induction of G0/G1 cell cycle arrest and apoptosis via p53 and p21 expression
    Seo Young Kim
    Major in Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea
    Ann N Y Acad Sci 1171:270-5. 2009
    ..L.lac CF caused G0/G1 cell cycle arrest, which was associated with an increase in p53 and p21 expression, the reduction of cyclin D1 expression, and retinoblastoma protein phosphorylation. L...
  59. doi Association of selected polymorphisms of CCND1, p21, and caspase8 with colorectal cancer risk
    Bing Liu
    Department of Epidemiology and Health Statistics, Zhejiang University, Hangzhou, China
    Mol Carcinog 49:75-84. 2010
    ..The study population was composed of 373 CRC cases and 838 controls. Five genetic variants including CCND1 G870A, p21 codon31 C/A, p21 3'UTR C/T, caspase8 IVS12-19G/A, and caspase8 6n del/ins were genotyped...
  60. doi The antioxidant quercetin inhibits cellular proliferation via HIF-1-dependent induction of p21WAF
    Aline Bach
    Department of Chemistry, University of Kaiserslautern, Kaiserslautern, Germany
    Antioxid Redox Signal 13:437-48. 2010
    ..These results provide evidence that quercetin inhibits the cell cycle and that induction of the HIF-system contributes to these effects of quercetin...
  61. pmc A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A
    Q Liu
    Department of Biological Sciences, University of Toledo, Toledo, OH, USA
    Oncogene 29:2843-52. 2010
    ..CDKN1A encoding p21(Cip1) has been identified as a Gfi-1 target gene and has been shown to contain Gfi-1 binding sites in the upstream ..
  62. pmc GATA-1 directly regulates p21 gene expression during erythroid differentiation
    Michael Papetti
    1Department of Cell Biology, Montefiore Medical Center, Bronx, NY, USA
    Cell Cycle 9:1972-80. 2010
    ..An early event in reprogramming the erythroleukemia cells is induction of the cyclin-dependent kinase inhibitor p21. Remarkably, ectopic expression of p21 also induces the erythroleukemia cells to differentiate...
  63. pmc p21CIP-1/WAF-1 induction is required to inhibit prostate cancer growth elicited by deficient expression of the Wnt inhibitor Dickkopf-1
    Christopher L Hall
    Department of Urology, The University of Michigan, Ann Arbor, Michigan, USA
    Cancer Res 70:9916-26. 2010
    ..osteoblast cell lines; however, DKK-1 knockdown PCa cells exhibited increased expression of the CDK inhibitor p21(CIP1/WAF1) and a 32% increase in G(1) arrest compared with control cells...
  64. doi Knockdown of p21(Cip1/Waf1) enhances proliferation, the expression of stemness markers, and osteogenic potential in human mesenchymal stem cells
    Tu Lai Yew
    Department of Dentistry, Institute of Oral Biology, National Yang Ming University, Taipei 112, Taiwan
    Aging Cell 10:349-61. 2011
    ..Further, late-passage MSCs showed increased expression of p21(Cip1/Waf1) (p21), an inhibitor of the cyclin-dependent kinase...
  65. doi Hypoxia inhibits cellular senescence to restore the therapeutic potential of old human endothelial progenitor cells via the hypoxia-inducible factor-1α-TWIST-p21 axis
    Sang Hun Lee
    From the Laboratory for Vascular Medicine and Stem Cell Biology, Medical Research Institute, Department of Physiology, School of Medicine, Pusan National University, Yangsan, Korea S H L, J H L, S Y Y, S M K Immunoregulatory Therapeutics Group in Brain Busan 21 Project S H L, J H L, S Y Y, S M K, Department of Medical Biolotechnology S H L, Soonchunhyang University College of Medicine, Seoul, Korea National Research Laboratory for Cardiovascular Stem Cell Niche, Innovative Research Institute for Cell Therapy J H, H S K, Cardiovascular Center and Department of Internal Medicine, Seoul National University Hospital, and Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Korea H S K
    Arterioscler Thromb Vasc Biol 33:2407-14. 2013
    ..The senescence repair circuit of hypoxia-preconditioned senescent EPCs (hyp-old EPCs) was examined in an effort to enhance their regenerative potential...
  66. ncbi Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells
    G Orend
    La Jolla Cancer Research Center, The Burnham Institute, California 92037, USA
    Oncogene 16:2575-83. 1998
    ..This anchorage-dependent cell cycle arrest is linked to increased expression of the p21Cip1 (p21) and p27Kip1 (p27) cyclin-dependent kinase inhibitors...
  67. ncbi Lack of evidence that proline homozygosity at codon 72 of p53 and rare arginine allele at codon 31 of p21, jointly mediate cervical cancer susceptibility among Indian women
    Paramita Bhattacharya
    Human Genetics Unit, Indian Statistical Institute, 203 B T Road, Kolkata 700 108, India
    Gynecol Oncol 99:176-82. 2005
    ..The objective of this study was to identify whether variants of p53Arg72Pro and p21Ser31Arg were associated with increased risk for cervical cancer (CaCx), either independently or jointly, among Indian women...
  68. doi The nonsynonymous single-nucleotide polymorphisms in codon 31 of p21 gene and the susceptibility to cervical cancer in Chinese women
    Qifang Tian
    Department of Gynecologic Oncology, Women s Reproductive Health Laboratory, Women s Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    Int J Gynecol Cancer 19:1011-4. 2009
    It was suggested that single-nucleotide polymorphisms in p21 codon 31 seem to be associated with a variety of human malignancies; very few studies have focused on the association between p21 codon 31 polymorphisms and cervical cancer...
  69. ncbi P53 codon 72 and p21 codon 31 polymorphisms and susceptibility to cervical adenocarcinoma in Korean women
    Ju Won Roh
    Department of Obstetrics and Gynecology, Dongguk University, Goyang, Korea
    Oncol Res 18:453-9. 2010
    The aims of this study were to evaluate the genotype frequencies of p53 codon 72 and p21 codon 31 in cervical adenocarcinoma patients and controls, and the association between the specific genotype or genotype combination of these ..
  70. doi Role of p53 and p21 polymorphisms in the risk of cervical cancer among Chinese women
    Pei Jiang
    Central South University, Changsha, China
    Acta Biochim Biophys Sin (Shanghai) 42:671-6. 2010
    The objective of this study was to identify whether polymorphic variants of p53 at codon 72 and p21 at codon 31 were associated with increased risk for cervical cancer, either independently or jointly, among Chinese women from southern ..
  71. pmc VentX trans-activates p53 and p16ink4a to regulate cellular senescence
    Xiaoming Wu
    Gastroenterology Division, The Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 286:12693-701. 2011
    ..Here, we show that VentX is a direct transcriptional activator of p53-p21 and p16ink4a-Rb tumor suppression pathways...
  72. ncbi Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1
    Guangdong Yang
    Department of Physiology, College of Medicine, The Cardiovascular Research Group, Saskatoon, Sastatchewan, Canada
    J Biol Chem 279:49199-205. 2004
    ..Moreover, exogenous H2S induced a sustained ERK and p21Cip/WAK-1 activation. These findings support the hypothesis that endogenously produced H2S may play a fundamental role in cell proliferation and survival...
  73. pmc A human herpesvirus microRNA inhibits p21 expression and attenuates p21-mediated cell cycle arrest
    Eva Gottwein
    Department of Molecular Genetics and Microbiology and Center for Virology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Virol 84:5229-37. 2010
    ..Here, we report that cellular mRNAs encoding the cellular cyclin-dependent kinase inhibitor p21, a key inducer of cell cycle arrest, are direct targets for KSHV miR-K1...
  74. pmc A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome
    R Touitou
    Virology and Cell Biology and Ludwig Institute for Cancer Research, Imperial College of Science, Technology and Medicine, Norfolk Place, London W2 1PG, UK
    EMBO J 20:2367-75. 2001
    The cyclin-dependent kinase inhibitor p21WAF1/CIP1 is a key regulator of cell-cycle progression and its expression is tightly regulated at the level of transcription and by proteasome-dependent proteolysis...
  75. ncbi Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
    Utz Herbig
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    Mol Cell 14:501-13. 2004
    ..damage response factors were assembled in a subset of senescent cells and signaled through ATM to p53, upregulating p21 and causing G1 phase arrest...
  76. doi Several common variants modulate heart rate, PR interval and QRS duration
    Hilma Holm
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 42:117-22. 2010
    ..00032, respectively), between TBX5 and advanced atrioventricular block (P = 0.0067), and between SCN10A and pacemaker implantation (P = 0.0029). We also replicated previously described associations with the QT interval...
  77. ncbi Identification of promoter elements responsible for transcriptional inhibition of polo-like kinase 1 and topoisomerase IIalpha genes by p21(WAF1/CIP1/SDI1)
    Hongming Zhu
    Department of Molecular Genetics, University of Illinois at Chicago, 60607 7170, USA
    Cell Cycle 1:59-66. 2002
    Induction of p21 (WAF1/CIP1/SDI1), a physiological mediator of cell cycle arrest, inhibits multiple genes involved in cell division...
  78. ncbi Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners
    Isabelle Frouin
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, via Abbiategrasso 207, 27100 Pavia, Italy
    J Biol Chem 278:39265-8. 2003
    ..Unexpectedly, PARP-1 activity also decreased in the presence of p21waf1/cip1. By pull-down experiments, we provided the first evidence for an association between PARP-1 and p21, which involves ..
  79. pmc Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding
    Lisa Heron-Milhavet
    Cell Biology Unit, Institut de Genetique Humaine, CNRS UPR1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Mol Cell Biol 26:8267-80. 2006
    ..overexpression of Akt2 reduced cyclin A and hindered cell cycle progression in M-G1 with increased nuclear p21. p21 is a major target in the differential effects of Akt isoforms, with endogenous Akt2 and not Akt1 binding p21 ..
  80. ncbi Polymorphism of the WAF1 gene is related to susceptibility to cervical cancer in Japanese women
    Y Harima
    Department of Radiology, Kansai Medical University, Moriguchi City, Osaka 570 8507, Japan
    Int J Mol Med 7:261-4. 2001
    The WAF1 gene, located on chromosome 6p21.2, has been cloned and identified as a p53 mediator and an inhibitor of G1 cyclin-dependent kinases (CDKs)...
  81. ncbi The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoter
    George Koutsodontis
    Department of Basic Sciences, University of Crete Medical School and Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology of Hellas, Herakleion GR 71110, Greece
    Biochemistry 41:12771-84. 2002
    ..all six GC-rich motifs (elements 1-6) present in the proximal promoter of the human cell cycle inhibitor p21(WAF-1/Cip1) gene...
  82. ncbi 9-Hydroxystearic acid upregulates p21(WAF1) in HT29 cancer cells
    N Calonghi
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    Biochem Biophys Res Commun 314:138-42. 2004
    ..In response to 9-HSA treatment of HT29 we observed cell growth arrest and increase in p21(WAF1) expression both at the transcriptional and the translational levels...
  83. ncbi p53 Binding to the p21 promoter is dependent on the nature of DNA damage
    Richard Hill
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    Cell Cycle 7:2535-43. 2008
    ..How p53 dictates cell fate is unclear. As a major transcriptional target of p53 in response to cellular stress, p21 is a key component in cell cycle control and apoptosis, directing an anti-apoptotic response following DNA damage...
  84. pmc p21(waf) correlates with DNA replication but not with prognosis in invasive breast cancer
    U J Göhring
    Department of Gynecology and Obstetrics, University of Cologne, 50924 Cologne, Germany
    J Clin Pathol 54:866-70. 2001
    b>p21(waf) plays a central role both in the regulation of the cell cycle and in DNA replication. Accordingly, p21(waf) is a putative tumour suppressor...
  85. ncbi Association between the p21 codon 31 A1 (arg) allele and lung cancer
    A Själander
    Department of Medical Genetics, Umea University, Sweden
    Hum Hered 46:221-5. 1996
    ..In this paper the codon 31 polymorphism of the p53-inducible protein p21 was studied in 144 Swedish lung cancer patients and two different control groups: 95 patients with chronic ..
  86. ncbi p21(Cip1) Promotes cyclin D1 nuclear accumulation via direct inhibition of nuclear export
    Jodi R Alt
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Biol Chem 277:8517-23. 2002
    There is increasing evidence that p21(Cip1) and p27(Kip1) are requisite positive regulators of cyclin D1.CDK4 assembly and nuclear accumulation...
  87. ncbi AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival
    Ying Li
    Department of Molecular Oncology, Genentech, Inc, San Francisco, California 94080, USA
    J Biol Chem 277:11352-61. 2002
    p21(Cip1/WAF1) (p21), a p53-inducible protein, is a critical regulator of cell cycle and cell survival. p21 binds to and inhibits both the DNA synthesis regulator proliferating cell nuclear antigen and cyclin A/E-CDK2 complexes...
  88. ncbi The cyclin-dependent kinase inhibitor p21CIP/WAF is a positive regulator of insulin-like growth factor I-induced cell proliferation in MCF-7 human breast cancer cells
    Joelle Dupont
    Section on Molecular and Cellular Physiology, Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    J Biol Chem 278:37256-64. 2003
    ..MCF-7 cells transiently overexpressing p21 showed increased basal and IGF-I-induced thymidine incorporation...
  89. pmc Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 tax oncoproteins modulate cell cycle progression and apoptosis
    Michelle Sieburg
    SUNY Upstate Medical University, Department of Microbiology and Immunology, 750 East Adams St, Syracuse, NY 13210, USA
    J Virol 78:10399-409. 2004
    ..Tax1 markedly activated transcription from the cdk inhibitor p21(cip1/waf1) promoter in comparison to Tax2, suggesting that upregulation of p21(cip1/waf1) may account for the ..
  90. ncbi Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression
    Suzanne Carreira
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 OTL, UK
    Nature 433:764-9. 2005
    ..The results indicate that Mitf-mediated activation of p21Cip1 expression and consequent hypophosphorylation of Rb1 will contribute to cell cycle exit and activation of the ..
  91. ncbi Genetic polymorphisms of p21 are associated with risk of squamous cell carcinoma of the head and neck
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 26:1596-602. 2005
    The p21 (Waf1/Cip1/CDKN1A) protein regulates the transition from the G1 to the S phase and has an important role in modulating cell-cycle control, apoptosis and cell growth...
  92. ncbi p300 regulates p63 transcriptional activity
    Mary MacPartlin
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 280:30604-10. 2005
    ..p300, but not its acetylase-defective mutant AT2, stimulated p63gamma-dependent transcription and induction of p21 in cells, consequently leading to G1 arrest...
  93. ncbi Comprehensive assessment of P21 polymorphisms and lung cancer risk
    Yi Young Choi
    Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
    J Hum Genet 53:87-95. 2008
    The purpose of this study is to comprehensively evaluate potential functional polymorphisms in the P21 gene in relation to the risk of lung cancer...
  94. doi p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression
    Byeong Hyeok Choi
    Department of Biomedical Science and Technology, Research Center for Transcription Control, Institute of Biomedical Science and Technology, Konkuk University, Seoul, Korea
    Cancer Res 68:1369-77. 2008
    ..proliferation in part by suppressing cyclin D1 and inducing expression of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1)...
  95. ncbi Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer
    S Mousses
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Hum Mol Genet 4:1089-92. 1995
    Several groups have recently isolated and characterized an inhibitor of cyclin-dependent kinases, p21CIP1/WAF1 which is transcriptionally induced by wild-type but not mutant p53...
  96. ncbi A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen
    E Warbrick
    Department of Anatomy and Physiology, University of Dundee, Scotland, UK
    Curr Biol 5:275-82. 1995
    ..We have investigated the interaction between p21WAF1 and PCNA using a genetic two-hybrid screen and with arrays of synthetic peptides derived from the p21WAF1 protein sequence...
  97. ncbi p21 is a universal inhibitor of cyclin kinases
    Y Xiong
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724
    Nature 366:701-4. 1993
    ..in multiple quaternary complexes, each containing a CDK, cyclin, proliferating cell nuclear antigen and the p21 protein...
  98. ncbi Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA
    J M Gulbis
    Laboratory of Molecular Biophysics, The Rockefeller University, New York, New York 10021, USA
    Cell 87:297-306. 1996
    ..antigen) complexed with a 22 residue peptide derived from the C-terminus of the cell-cycle checkpoint protein p21(WAF1/CIP1) has been determined at 2.6 angstrom resolution...
  99. pmc Negative regulation of cell growth and differentiation by TSG101 through association with p21(Cip1/WAF1)
    Hyesun Oh
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 99:5430-5. 2002
    ..We report here that the TSG101 protein binds to the cyclin/cyclin-dependent kinase (CDK) inhibitor (CKI) p21(Cip1/WAF1) and increases stability of the p21 protein in HEK293F cells and differentiating primary keratinocytes, ..
  100. ncbi Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio
    Delphine Javelaud
    INSERM U365, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Biol Chem 277:37949-54. 2002
    p21(WAF1) appears to be a major determinant of the cell fate in response to anticancer therapy...
  101. ncbi The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein
    Keith M Giles
    Laboratory for Cancer Medicine and University Department of Medicine, Western Australian Institute for Medical Research and Centre for Medical Research, The University of Western Australia, Perth, Western Australia 6001, Australia
    J Biol Chem 278:2937-46. 2003
    ..The cyclin-dependent kinase inhibitor p21(WAF1) is a central component of this pathway...

Research Grants93

  1. Deregulated lipid metabolism in stroke
    Robert J Dempsey; Fiscal Year: 2013
    ..2A (PP1 and PP2A), (b) dephosphorylation of retinoblastoma (Rb) and Cdk2 and (c) up-regulation of Cdk inhibitors p21 and p27...
  2. Fiona Simpkins; Fiscal Year: 2016
    ..The cdk inhibitors, p21 and p27, are cycle negative regulators that are frequently reduced in many cancers, including OVCAs16, 17...
  3. Michele Pagano; Fiscal Year: 2016
    ..pivotal roles in cell cycle control, and defined the key steps leading to the degradation of the CDK inhibitors p21 and p27 via the F-box protein Skp2. Moreover, we found that APC/CCdh1, an SCF-like ligase, controls Skp2 stability...
  4. Mark S Ledoux; Fiscal Year: 2016
    ..CIZ1 was first recognized through its interaction with p21Cip1/Waf1, a cyclin-dependent kinase inhibitor involved in G1/S cell-cycle regulation and cellular differentiation...
  5. Role of p53 in cell cycle checkpoints
    James J Manfredi; Fiscal Year: 2013
    ..These include novel roles for Mdm2 in affecting the ability of p21CIP1 to inhibit cyclin-dependent kinases and in regulating Cdc25C protein stability...
  6. CBP Bromodomain Antagonists Block Androgen Receptor in Prostate Cancer
    SYED S MUJTABA; Fiscal Year: 2010
    ..interaction that is essential for p53-induced transcriptional activation of the cyclin dependent kinase inhibitor, p21, involved in G1 cell cycle arrest...
  7. The Role of HNF4alpha in Cell Proliferation
    Linh Vuong; Fiscal Year: 2013
    ..Recently, we have shown that HNF411 upregulates cyclin dependent kinase inhibitor p21, a cell cycle inhibitor;we have also shown that the oncoprotein c-Myc abolishes this activity...
  8. Edward T Kipreos; Fiscal Year: 2015
    ..Aim 1 focuses on CRL2-mediated regulation of the CDK-inhibitors p21Cip1 and p27Kip2 in the cytoplasm...
  9. Cux-1 and cell cycle regulation in kidney development
    Gregory Vanden Heuvel; Fiscal Year: 2009
    ..Cux-1 represses the expression of the cyclin kinase inhibitor p21 in S phase and is part of the network controlling G1-S transition...
  10. Chou Zen Giam; Fiscal Year: 2014
    ..The mRNA level of another CKI, p21, also increases sharply as a result of promoter activation and mRNA stabilization by Tax...
  11. Petras P Dzeja; Fiscal Year: 2016
    ..capacity depends on AK2 expression and dynamics of AMP-signaling through AK-AMP-AMPK axis which is a part of p53/p21/cyclin metabolic checkpoint regulating G1/S cell cycle transition...
  12. Constantinos Koumenis; Fiscal Year: 2016
    ..the following three specific aims: In Aim 1, we will determine the role of the cyclin-dependent kinase inhibitor p21 in mediating cell-cycle arrest and survival in response to hypoxia and nutrient deprivation in ISR-proficient and ..
  13. George Miller; Fiscal Year: 2016
    ..in the epithelial compartment, characterized by dysregulated expression of numerous cell cycle regulators (p16, p21, p27, p53, Cyclin B1, Cyclin D1) and oncogenic genes (c-myc, Rb, and SHPTP1)...
  14. Xinbin Chen; Fiscal Year: 2016
    ..Among these is p21, a cyclin-dependent kinase inhibitor that mediates p53 to induce cell cycle arrest...
  15. Xiaoqi Liu; Fiscal Year: 2016
    ..Initially identified as a factor that leads to cell cycle arrest, p21CIP1/WAF1 can be induced by both p53-dependent and -independent mechanisms...
  16. TARGETED MANIPULATION OF STEM CELLS FOR AIDS THERAPY
    David T Scadden; Fiscal Year: 2010
    ..They defined in detail distinctive phenotypes associated with the genetic deficiency of p21Cip1 (p21), p27Kip1 (p27), p18INK4c (p18) and p16INK4a (p16)...
  17. Analysis of FIP200 in signal transduction
    Jun Lin Guan; Fiscal Year: 2012
    ..found that FIP200 inhibited cell cycle progression through its regulation of the cyclin dependent kinase inhibitor p21 and cyclin D1 in breast cancer cells...
  18. Chou Zen Giam; Fiscal Year: 2014
    ..The mRNA level of another CKI, p21, also increases sharply as a result of promoter activation by Tax and mRNA stabilization due to Tax-induced APC/C ..
  19. Andreas Friedl; Fiscal Year: 2016
    ..cyclin E and cyclin-dependent kinase 2 (CDK2) and the suppression of the cyclin-dependent kinase inhibitors (CKIs) p21 and p27. These coordinated changes in cell cycle regulators lead to G1-S-transition and DNA replication...
  20. Regulation of Nucleotide Excision Repair by Proteolysis
    Pengbo Zhou; Fiscal Year: 2013
    ..Interestingly, our in vivo studies revealed dramatic upregulation of the cyclin-dependent kinase inhibitor p21/CIP1/WAF1 in CUL-4A-/- and DDB1-/- mice, as well as in MEF cells and keratinocytes derived from these mice...
  21. Chemical Modulators for p53 Functions in Transcriptional Regulation
    SYED S MUJTABA; Fiscal Year: 2012
    ..interaction that is essential for p53-induced transcriptional activation of the cyclin dependent kinase inhibitor p21, involved in G1 cell cycle arrest...
  22. Inhibitors of disease-promoting activities of senescence
    DONALD PORTER; Fiscal Year: 2009
    ..to the expression of cell cycle inhibitors of cyclin-dependent kinase inhibitor (CKI) family, such as p21Waf1/Cip1 or p16Ink4A...
  23. HARRIS R PERLMAN; Fiscal Year: 2014
    ..We were the first to demonstrate that expression of the cyclin dependent kinase (CDK) inhibitor p21(WAF1/CIP1) is reduced in synovial tissue from RA patients compared to osteoarthritis patients...
  24. ROBERT SMALLRIDGE; Fiscal Year: 2014
    ..in anaplastic thyroid cancer (ATC) models in vitro and in vivo and that the cyclin kinase inhibitor, p21WAF1/CIP1 (p21), is necessary for PPAR3- mediated growth inhibition and for the apoptotic synergy induced by the combination...
  25. Jian Yu; Fiscal Year: 2014
    ..Work from us and others indicate that the BH3-only protein PUMA and cyclin-dependent kinase inhibitor p21 regulate the survival and regeneration of intestinal and hematopoietic systems, and the bone marrow modulates ..
  26. TAREK A ABBAS; Fiscal Year: 2014
    ..destruction of the replication initiation protein Cdt1 and the cyclin-dependent kinase (CDK) inhibitor p21, both in S-phase of the cell cycle and in response to UV irradiation...
  27. Transcriptional regulation of apoptosis
    James J Manfredi; Fiscal Year: 2013
    ..the interplay between Sp/KLF family members and p53 on regulating gene expression, focusing on the role of p21CIP1 as an attenuator of the apoptotic response, and elucidating whether alterations in basal levels of expression of ..
  28. Transcriptional Regulation of Myogenic Stem Cells
    Daniel J Garry; Fiscal Year: 2013
    ..stem cells that have perturbed cell cycle kinetics and an induction of the cyclin dependent kinase inhibitor, p21. We provide new preliminary data supporting a novel pathway whereby Foxk1 contributes to a repression complex that ..
  29. Scott D Cramer; Fiscal Year: 2014
    ..blocks proliferation, induces cell cycle arrest, and increases expression of cyclin-dependent kinase inhibitors p21 and p27. Our data suggest that 1,25(OH)2D3 promotes differentiation of the PrP/SC...
  30. Cyclin-dependent Kinase Inhibitor In Acute Renal Failure
    Peter M Price; Fiscal Year: 2013
    ..Now we find that in response to cisplatin, Cdk2 phosphorylates two proteins, p21 and Bcl xL, that directly and indirectly could have effects on cell death pathways...
  31. MNF regulation of myogenic stem cells
    Daniel J Garry; Fiscal Year: 2011
    ..mice that lack Foxkl have impaired muscle regeneration, dysregulation of the cyclin dependent kinase inhibitor, p21, and perturbed cell cycle progression of the MPC population...
  32. Role of the SCF/FBX011 ubiquitin ligase in the control of cell proliferation
    Michele Pagano; Fiscal Year: 2013
    ..CRL4Cdt2 controls the degradation of key regulators of proliferation (Cdt1, p21, Set8, etc...
  33. Physiologic Regulation of Hematopoiesis by Notch
    Nadia Carlesso; Fiscal Year: 2011
    ..activation of SKP2, the F-box subunit of the SCFskp2 complex that targets the cell cycle inhibitors p27Kip1 and p21Cip1 for degradation, promoting their downregulation and the entry into S-phase...
  34. Rakesh Kumar; Fiscal Year: 2014
    ..One molecule known to cause progression of breast cancer cells to more invasive phenotypes is p21-activated kinase 1 (Pak1), a nodular kinase activated by a variety of cell surface or intracellular signals...
  35. Role of Kruppel-Like Factor 4 in Wnt and Notch Signaling in the Intestinal Tract
    Amr Ghaleb; Fiscal Year: 2010
    ..KLF4 negatively regulates cellular proliferation by up-regulating the cyclin-dependent kinase inhibitor, p21WAF1/Cip1. Recent work from our lab indicated that KLF4 is a potential tumor suppressor for colorectal cancer...
  36. SMOOTH MUSCLE CELL PROLIFERATION IN HUMAN CORONARY ARTERY BYPASS GRAFTS
    Devendra K Agrawal; Fiscal Year: 2012
    ..overexpression on Ang-II and IGF-1-induced expression and activation of cyclin- dependent kinase inhibitors (CKIs;p21, p27, and p53), cyclin D and E, Rb protein and E2F in SMCs of human SV and IMA, and on the resultant proliferation...
  37. Thyroid regulation of cardiomyocyte maturation
    KENT L R THORNBURG; Fiscal Year: 2013
    ..Hypothesis: Both MAPK and PI3K are activated by T3, but proliferation is regulated by MAPK and its interaction with p21. The importance of the MAPK and PI3K signaling cascades in regulating proliferation under the influence of T3 will ..
  38. Selene Bobadilla; Fiscal Year: 2016
    ..Our laboratory recently uncovered that TAF1 phosphorylates p53 at Thr55 on the p21 promoter and this phosphorylation leads to dissociation of p53 from the promoter and termination of p21 ..
  39. Xuan Liu; Fiscal Year: 2016
    ..Upon DNA damage, K373/K382 diacetyl-p53 directly interacts with the double-bromodomain of TAF1 and recruits TAF1 to p21 promoter independent of other subunits of TFIID, leading to p21 activation...
  40. MODELING AND RESCUE OF DBA IN THE MOUSE
    Philip J Mason; Fiscal Year: 2010
    ..with a wild type p53 response, depletion of ribosomal proteins causes cell cycle arrest and induction of p53 and p21. Interestingly, this response and cell cycle arrest can be abrogated by simultaneous depletion of either p53 or ..
  41. NIALL GEORGE HOWLETT; Fiscal Year: 2015
    ..Towards this goal, we have recently determined that the p21 cyclin dependent kinase inhibitor plays an important role in the regulation of DNA damage-inducible FANCD2 mono-..
  42. Juanita L Merchant; Fiscal Year: 2014
    ..and binding to GC-rich DNA elements in several promoters including the cyclin-dependent kinase inhibitor (CDKI) p21. Butyrate also triggers auto-phosphorylation of ATM at serine 1981 (pATMS1981) that subsequently complexes with ZBP-..
  43. Liang You; Fiscal Year: 2014
    ..Knockdown of Cul4A by shRNA leads to increased p21 protein, and subsequently induces cell cycle arrest and inhibits mesothelioma cell growth...
  44. Joseph R Testa; Fiscal Year: 2016
    ..The protein product of the NF2 gene, Merlin, binds to and inhibits p21-activated protein kinases (Paks), enzymes that positively regulate cell cycle progression, survival, and motility...
  45. Mechanisms of Pituitary Tumorigenesis
    Shlomo Melmed; Fiscal Year: 2012
    ..induction of Pttg transcription and protein expression in Rb mice, in mutant human cancer cells devoid of p53 or p21, as well as in human pituitary adenomas...
  46. Role of cellular senescence in mammary cancer prevention by Rexinoids.
    Konstantin Christov Tzelkov; Fiscal Year: 2010
    ..transgenic mice which spontaneously develop ER- mammary tumors;(ii) Determine the role of p53, p16Ink4a and p21Waf1/Cip1 expression in mediating the senescent program of rexinoids in mammary premalignant and tumor cells...
  47. The role of E47 in uncommitted hematopoietic progenitors
    Lisa Borghesi; Fiscal Year: 2013
    ..of function and loss of function studies identify two key genes as candidate E47 targets: the cell cycle regulator p21 and the transcriptional regulator Ikaros...
  48. Maureen E Murphy; Fiscal Year: 2016
    ..factor, and it elicits growth arrest primarily through transactivation of the cyclin-dependent kinase inhibitor p21/waf1. In order to induce death p53 transactivates pro-apoptotic target genes such as the BH3-only proteins PUMA and NOXA;..
  49. Martin Carroll; Fiscal Year: 2015
    ..a subunit of PI3 kinase not normally expressed in hematopoietic cells designated PIK3R3, and the cyclin inhibitor p21. Specific Aims 3 and 4 will determine if STAT5 is a direct target of SFK's and what the important targets of ..
  50. Siddhartha Mukherjee; Fiscal Year: 2016
    ..Previous studies have implicated a few genes in the maintenance of quiescence, such as p21 and Gfi-1, but other pathways remain unknown...
  51. Zhenkun Lou; Fiscal Year: 2015
    ..A major function of p53 is to activate the expression of its target genes, such as p21 and PUMA in response to cellular stress, thereby regulating cell cycle progression and apoptosis...
  52. Benjamin E Turk; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The Sterile-20 (Ste20) family of the protein kinome includes both the p21-activated kinase (PAK) and germinal center kinase III (GCKIII) families...
  53. FUNCTION OF MEF IN HEMATOPOIETIC CELLS
    Stephen Nimer; Fiscal Year: 2011
    ..We will further define how known cell cycle regulatory genes, such as p21, modulate the effects of MEF on HSC self-renewal processes...
  54. Understanding the Roles of REGgamma in Anaplastic Thyroid Cancer Progression
    Xiaotao Li; Fiscal Year: 2011
    ..Genetically, alteration of p53, p21Waf/Cip1 as well as other cell cycle regulators may be responsible for the transformation of well-differentiated thyroid ..
  55. Heat shock protein 90 antagonist-based therapy of mantle cell lymphoma
    Kapil Bhalla; Fiscal Year: 2012
    ..g., vorinostat (SAHA) or LBH589, was shown to increase the levels of the CDK inhibitors p21 and p27, induce several pro-apoptotic and attenuate antiapoptotic proteins, including AKT and c-Raf, in MCL cells...
  56. Gadiparthi N Rao; Fiscal Year: 2016
    ..growth and motility require NFATc1-cyclin D1-dependent activation of protein kinase C-related kinase 1 (PRK1) and p21-activated kinase 1 (PAK1) and 3. Smooth muscle (SM)-NFATc1 mediates vascular wall remodeling...
  57. REGULATION OF CYCLIN D1 EXPRESSION
    Richard G Pestell; Fiscal Year: 2010
    ..We have identified cyclin D1-interacting proteins (PACSIN2, cdks, pRb, p27/p21, HDACs). We will determine the role of cyclin D1- interacting proteins in promoting cellular migration and invasion...
  58. Julien Sage; Fiscal Year: 2016
    ..We will first test the specific hypothesis that activation of p21 by E2F in the TKO model blocks the proliferation of hepatocytes, thereby preventing HCC initiation from these ..
  59. Lipid hydroxylation in glial cell signaling and myelination
    Hiroko Hama; Fiscal Year: 2012
    ..Cellular 2-OH also partially blocked the upregulation of cyclin-dependent kinase inhibitors, p21 and p27, in response to a stimulus for differentiation...
  60. Identification and study of the vascular disease gene at 9p21.3
    Thomas Quertermous; Fiscal Year: 2013
    ..single region of the genome as the most highly associated with disease in an intergenic segment of chromosome 9 at p21.3, the Chromosome 9p21.3 CHD-Associated Region (C9CAR)...
  61. Kale S Bongers; Fiscal Year: 2015
    ..Through these studies, we hope to identify a central pathway that drives skeletal muscle atrophy and, in doing so, identify new therapeutic targets to treat this devastating condition, which affects millions of Americans annually. ..
  62. Secretory Patterns of Senescent Tumor Cells
    Igor B Roninson; Fiscal Year: 2011
    ..Expression of cyclin-dependent kinase inhibitor (CDKI) proteins (such as p21/Waf1), which are frequently upregulated in senescent cells, enhances the production of tumor-promoting factors...
  63. Mathias Lichterfeld; Fiscal Year: 2015
    ..CD4 T cells from elite controllers was mediated by a strong upregulation of the cyclin- dependent kinase inhibitor p21 (waf-1/cip-1), which was able to independently suppress HIV-1 reverse transcription and mRNA transcription...
  64. THE ROLE OF P21 IN THE REPLICATION OF DAMAGED DNA
    Carol Prives; Fiscal Year: 2013
    ..Prives in Columbia University and supported by the FIRCA RO3TW007440, indicates that the cyclin kinase inhibitor p21 is a potent negative regulator of those TLS features...
  65. Katherine A Jones; Fiscal Year: 2016
    ..In the cell, SKIP is required for expression of the anti-apoptotic p21Cip1 protein, a potent inhibitor of HIV-1 replication...
  66. Howard B Lieberman; Fiscal Year: 2016
    ..RAD9 can bind p53 consensus sequences in the p21 promoter and cause transcription when overexpressed...
  67. Thomas M Aune; Fiscal Year: 2014
    ..or other intrinsic pathways, these repair mechanisms;ATR, DNA-PKcs, and ATM, and cell cycle checkpoints, JNK2, p53, p21, p27, CHEK2, RANGAP1 are defective resulting in failure of DNA repair and loss of genomic integrity...
  68. Jonathan P Katz; Fiscal Year: 2016
    ..converts KLF5 from pro-proliferative to anti-proliferative, an effect mediated predominantly by p21Waf1/Cip1, and KLF5 transcriptionally activates the keratinocyte tumor suppressor NOTCH1 when p53 is mutant but not with wild-..
  69. Mark W Feinberg; Fiscal Year: 2016
    ..of Smad1 and reduced its expression, an effect that decreased Id1 expression and increased cell cycle arrest genes p21 and p27 in ECs...
  70. Nicholas F Larusso; Fiscal Year: 2016
    ..cholangiocytes are activated to initiate downstream signaling pathways involving Nuclear Factor Kappa B (NF?B), the p21 Ras isoform, Mitogen Activated Protein Kinase (MAPK) and post-transcriptional regulatory networks involving ..
  71. Mechanisms of DNA damage-induced, p53-dependent repression of the Cdc25C Phosphat
    Luis A Carvajal; Fiscal Year: 2012
    ..Additional factors, such as p21, may be required for this repression...
  72. WILLIAM SCHIEMANN; Fiscal Year: 2016
    ..in mice, doing so by inducing TNBCs to undergo mesenchymal-epithelial transition programs coupled to elevated p21 expression, and to diminished expression of matrix metalloproteinases...
  73. Douglas N Robinson; Fiscal Year: 2014
    ..this proposal, testing the specific hypothesis that a signaling module composed of the small GTPase Rac1, 14-3-3, p21-activated kinase, and IQ-motif and GTPase-containing protein regulates the oocyte's structural cytoskeletal ..
  74. Mechanisms of Delta-N-p63-alpha transcriptional repression and its role in squamo
    CORRIE LYNN GALLANT-BEHM; Fiscal Year: 2013
    ..exhaustive chromatin immunoprecipitation (ChIP) analysis of the transcriptional events taking place at the NOXA and p21 loci before and after Np631 knockdown under conditions of both basal and activated p53, the precise regulatory ..
  75. Richard L Eckert; Fiscal Year: 2016
    ..Key polycomb group proteins, including Ezh2, are overexpressed in skin cancer and this drives silencing of p21Cip1 and other tumor suppressors leading to enhanced tumor cell survival...
  76. ELIZABETH PATRICIA CROWE; Fiscal Year: 2015
    ..secretory phenotype (SASP) and activation of the major senescence signaling pathways: p38MAPK, p53-p21, and p16INK4a-Rb in astrocytes...
  77. Mechanisms of Early Life Stress-Induced Endothelial Dysfunction
    Dao Ho; Fiscal Year: 2013
    ..Control litters remained undisturbed until weaning on P21. MSEW did not have any effect on overall body weight (P2-P84)...
  78. Novel Transcriptional Regulators of Angiogenesis
    Antonino Passaniti; Fiscal Year: 2009
    ..RUNX2 also represses the promoter of p21Cip1, a cyclin-dependent kinase inhibitor, inhibits p21Cip1 protein expression, and reduces TGFb-mediated growth ..
  79. MICHAEL DYLE; Fiscal Year: 2015
    ..Through these studies, we hope to discover novel molecular mechanisms that control skeletal muscle mass, as well as new potential therapeutic targets for a disabling condition that affects millions of patients and elderly individuals. ..
  80. Involvement of APC in DNA Repair
    Satya Narayan; Fiscal Year: 2006
    ..nuclear antigen (PCNA) and apurinic/apyrimidinic endonuclease (APE), and the cell cycle kinase inhibitor protein, p21. PCNA and APE interact with APC at the PCNA-interacting protein (PIP)-box and p21 interacts at the C-terminal ..
  81. DEBORAH JEAN WATSON; Fiscal Year: 2014
    ..examine changes in dendritic SER organization during a period of robust synaptogenesis from postnatal day (P) 15 to P21. During this one postnatal week, oblique dendrites mature substantially in spine number and synapse size...
  82. Serotonin-limbic system interactions that mediate anxiety
    Sheryl G Beck; Fiscal Year: 2013
    ..optogenetic stimulation will be used to test the hypothesis that projection fibers to the mPFC mature between P12-P21 leading to the release of both glutamate and 5-HT and that mPFC neurons mature physiologically between P4 and P21...
  83. Regulation of p53 by BRCA1 in Breast Cancer
    JOY CHIEH YU LIN; Fiscal Year: 2013
    ..ChIP assays and transcriptional activation assays on p21/bax promoter in the presence/absence of p53, p3OO or BRCA1 will be used to dissect the functional connections ..
  84. Proteolytic Pathways in Progression of Pre-Malignant Breast Disease
    Bonnie F Sloane; Fiscal Year: 2013
    ..Aberrant signal transduction, for example through p21-activated kinase 1 [PAK1], may contribute to increased pericellular proteolysis...
  85. CKIS AND CONTROL OF VASCULAR SMOOTH MUSCLE CELL CYCLE
    David Ginsburg; Fiscal Year: 2001
    ..The goal of this grant is to study control of VSMC cycle by p21 and p27 cyclin-dependent kinase inhibitors (CKIs)...
  86. Maryann Obiorah; Fiscal Year: 2014
    ..to the third trimester of human development (postnatal day 7 - P7), prepubescence (P14), and adolescence (P21). Next, the effects of a single early exposure (P7) on later adult neurogenesis (P21, P42) will be studied...
  87. Cell Cycle Inhibition in Systemic Autoimmunity
    DWIGHT KONO; Fiscal Year: 2009
    This project will focus on defining the role of the cell cycle inhibitor, p21, in normal immune and autoimmune responses. The cell cycle plays a critical role in determining the fate and differentiation state of cells...
  88. Robert S Tepper; Fiscal Year: 2016
    ..As p21-activated protein kinases (PAK) are involved in regulation of F-actin dynamics, they may provide a molecular target ..
  89. Michael Y Sherman; Fiscal Year: 2014
    ..This Aim is based on our data that (1) Her2 induces the senescence-associated protein p21 both in human and mouse mammary epithelium, (2) p21 in addition to senescence can regulate epithelium mesenchymal ..
  90. Role of p21 in antidepressant-induced neurogenesis
    Vera Chesnokova; Fiscal Year: 2009
    ..Our preliminary studies demonstrate that in the mouse, p21, a cyclin-dependent kinase inhibitor, is abundantly expressed in the subgranular zone of the dentate gyrus, the ..
  91. Prostate Cancer Chemoprevention by Inositol Hexaphosphate Efficacy and Mechanism
    Rajesh Agarwal; Fiscal Year: 2010
    ..In PCA cell culture, completed studies by us show that IP6 up- regulates CDKI Kip1/p27 and Cip1/p21 levels together with their increased interaction with CDKs causing inhibition in the kinase activity of CDKs ..
  92. C/EBP ALPHA MEDIATED REGULATION OF P21/SDI-1
    Nikolai Timchenko; Fiscal Year: 2001
    ..We have shown that C/EBPalpha inhibits cell proliferation through p21/SDI-1 protein...
  93. TGF-BETA AND IMMUNOSUPPRESSION IN ORGAN TRANSPLANTATION
    Ashwani Khanna; Fiscal Year: 2002
    ..of immunosuppressive drugs, and TGF-B has been reported to induce the expression of one cell cycle inhibitor, p21. The investigators' that this phenomenon may be TGF-B- independent...