p16

Summary

Gene Symbol: p16
Description: cyclin dependent kinase inhibitor 2A
Alias: ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, CDK4 inhibitor p16-INK4, alternative reading frame, cell cycle negative regulator beta, cyclin-dependent kinase 4 inhibitor A, cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4), multiple tumor suppressor 1
Species: human

Top Publications

  1. ncbi ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    Y Zhang
    Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, 27599 3280, USA
    Cell 92:725-34. 1998
  2. ncbi Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    M Serrano
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cell 88:593-602. 1997
  3. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
  4. pmc A common allele on chromosome 9 associated with coronary heart disease
    Ruth McPherson
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa K1Y4W7, Canada
    Science 316:1488-91. 2007
  5. doi A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci
    Jin Xin Bei
    State Key Laboratory of Oncology in Southern China, Guangzhou, China
    Nat Genet 42:599-603. 2010
  6. pmc Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states
    Sunita K Agarwal
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1802, USA
    J Clin Endocrinol Metab 94:1826-34. 2009
  7. doi DNA methylation markers and early recurrence in stage I lung cancer
    Malcolm V Brock
    Johns Hopkins Hospital, Baltimore, USA
    N Engl J Med 358:1118-28. 2008
  8. ncbi ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
    Delin Chen
    Institute for Cancer Genetics, Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, New York 10032
    Cell 121:1071-83. 2005
  9. ncbi Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT
    Kei Haga
    Virology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuoku 104 0045, Tokyo, Japan
    Cancer Sci 98:147-54. 2007
  10. pmc Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
    Maggie C Y Ng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Diabetes 57:2226-33. 2008

Research Grants

  1. Melanoma in p16INK4a and p19ARF Deficient Mice
    NORMAN SHARPLESS; Fiscal Year: 2006
  2. Patrick N Cunningham; Fiscal Year: 2014
  3. Pathophysiology of sepsis-induced renal injury
    Pierre C Dagher; Fiscal Year: 2013
  4. Epigenetic Reprogramming by the Human Papillomavirus E7 Oncoprotein
    MARGARET ERIN MCLAUGHLIN-DRUBIN; Fiscal Year: 2012
  5. Epigenetic mechanisms underlying aberrant gene expression in cancer
    Sheila Chari; Fiscal Year: 2012
  6. P16 GENE FAMILY IN HEALTH AND DISEASE
    Gregory Hannon; Fiscal Year: 1999
  7. Lorraine J Gudas; Fiscal Year: 2014
  8. Thea D Tlsty; Fiscal Year: 2014
  9. Pesticide Exposure and DNA Methylation in Pesticide Applicators
    JENNIFER ANN RUSIECKI; Fiscal Year: 2010
  10. NICOLAS SCHLECHT; Fiscal Year: 2014

Detail Information

Publications411 found, 100 shown here

  1. ncbi ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    Y Zhang
    Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, 27599 3280, USA
    Cell 92:725-34. 1998
    The INK4a-ARF locus encodes two unrelated proteins that both function in tumor suppression. p16INK4 binds to and inhibits the activity of CDK4 and CDK6, and ARF arrests the cell cycle in a p53-dependent manner...
  2. ncbi Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    M Serrano
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cell 88:593-602. 1997
    ..primary cells by ras requires either a cooperating oncogene or the inactivation of tumor suppressors such as p53 or p16. Here we show that expression of oncogenic ras in primary human or rodent cells results in a permanent G1 arrest...
  3. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  4. pmc A common allele on chromosome 9 associated with coronary heart disease
    Ruth McPherson
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa K1Y4W7, Canada
    Science 316:1488-91. 2007
    ..Homozygotes for the risk allele make up 20 to 25% of Caucasians and have a approximately 30 to 40% increased risk of CHD...
  5. doi A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci
    Jin Xin Bei
    State Key Laboratory of Oncology in Southern China, Guangzhou, China
    Nat Genet 42:599-603. 2010
    ..61) and rs28421666 (Pcombined=2.49x10(-18), OR=0.67). Our findings provide new insights into the pathogenesis of NPC by highlighting the involvement of pathways related to TNFRSF19 and MDS1-EVI1 in addition to HLA molecules...
  6. pmc Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states
    Sunita K Agarwal
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1802, USA
    J Clin Endocrinol Metab 94:1826-34. 2009
    ..However, the prevalence of identifiable germline MEN1 mutations in familial MEN1 cases is only 70%. Some cases may have a germline mutation in another gene such as the p27 cyclin-dependent kinase inhibitor (CDKI)...
  7. doi DNA methylation markers and early recurrence in stage I lung cancer
    Malcolm V Brock
    Johns Hopkins Hospital, Baltimore, USA
    N Engl J Med 358:1118-28. 2008
    ..Despite optimal and early surgical treatment of non-small-cell lung cancer (NSCLC), many patients die of recurrent NSCLC. We investigated the association between gene methylation and recurrence of the tumor...
  8. ncbi ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
    Delin Chen
    Institute for Cancer Genetics, Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, New York 10032
    Cell 121:1071-83. 2005
    Although the importance of the ARF tumor suppressor in p53 regulation is well established, numerous studies indicate that ARF also suppresses cell growth in a p53/Mdm2-independent manner...
  9. ncbi Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT
    Kei Haga
    Virology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuoku 104 0045, Tokyo, Japan
    Cancer Sci 98:147-54. 2007
    ..been proposed that stress imposed by inadequate culture conditions induces senescence due to accumulation of p16(INK4a)...
  10. pmc Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
    Maggie C Y Ng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Diabetes 57:2226-33. 2008
    ..However, the implications of these genes in Asians are unclear...
  11. pmc The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
    F J Stott
    Imperial Cancer Research Fund Laboratories, P O Box 123, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    EMBO J 17:5001-14. 1998
    ..The product of the alpha transcript, p16(INK4a), is a recognized tumour suppressor that induces a G1 cell cycle arrest by inhibiting the phosphorylation of the ..
  12. pmc N-terminal polyubiquitination and degradation of the Arf tumor suppressor
    Mei Ling Kuo
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 18:1862-74. 2004
    ..p19Arf, although highly basic (22% arginine content), contains only a single lysine residue absent from human p14ARF, and substitution of arginine for lysine in mouse p19Arf had no effect on its rate of degradation...
  13. ncbi Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
    T Nobori
    Department of Medicine, University of California, San Diego, La Jolla 92093 0663
    Nature 368:753-6. 1994
    ..The CDK4 inhibitor is thought to be a physiological suppressor of proliferation. Cells unable to produce the inhibitor may be prone to neoplastic transformation...
  14. pmc Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents
    Alisa M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7236, USA
    J Med Genet 44:99-106. 2007
    ....
  15. doi Clinical risk factors, DNA variants, and the development of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    N Engl J Med 359:2220-32. 2008
    ..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts...
  16. pmc The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
    Adrian P Bracken
    Centre for Epigenetics, Biotech Research and Innovation Centre BRIC, University of Copenhagen, Copenhagen 2200, Denmark
    Genes Dev 21:525-30. 2007
    The p16INK4A and p14ARF proteins, encoded by the INK4A-ARF locus, are key regulators of cellular senescence, yet the mechanisms triggering their up-regulation are not well understood...
  17. pmc Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
    Sekar Kathiresan
    Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Genet 41:334-41. 2009
    ..SNPs at nine loci were reproducibly associated with myocardial infarction, but tests of common and rare CNVs failed to identify additional associations with myocardial infarction risk...
  18. doi MC1R variants increase melanoma risk in families with CDKN2A mutations: a meta-analysis
    Maria Concetta Fargnoli
    Department of Dermatology, University of L Aquila, L Aquila, Italy
    Eur J Cancer 46:1413-20. 2010
    ..We performed a meta-analysis to assess whether MC1R variants increase the risk of melanoma in CDKN2A mutation carriers of melanoma-prone families...
  19. doi The sensitivity and specificity of p16(INK4a) cytology vs HPV testing for detecting high-grade cervical disease in the triage of ASC-US and LSIL pap cytology results
    Karin J Denton
    North Bristol NHS Trust, Bristol, England
    Am J Clin Pathol 134:12-21. 2010
    We analyzed the performance of p16(INK4a) immunocytochemistry on a series of 810 retrospectively collected atypical squamous cells of undetermined significance (ASC-US) and low-grade squamous intraepithelial lesion (LSIL) cases with ..
  20. doi Human papillomavirus and p16 expression in inverted papillomas of the urinary bladder
    Victor E Gould
    Department of Pathology, Rush University, Chicago, USA
    Cancer Lett 292:171-5. 2010
    ..The cell cycle inhibitor p16(Ink4a) has been shown to be overexpressed in HPV-positive cervical pre-malignant and malignant lesions, probably as a ..
  21. ncbi Enforced expression of p14ARF induces p53-dependent cell cycle arrest but not apoptosis
    Stuart Gallagher
    Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead Hospital, Westmead, Australia
    Cell Cycle 4:465-72. 2005
    Expression of the p14ARF tumour suppressor is induced by hyperproliferative signals produced by RAS, MYC and other oncogenes...
  22. ncbi Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progression
    Zhihong Zhang
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Mod Pathol 19:1339-43. 2006
    ..p14(ARF), p15(INK4b), and p16(INK4a), which are known to regulate G1 cell cycle arrest, and the tumor necrosis factor receptor superfamily member ..
  23. doi CDKN2A mutations and MC1R variants in Italian patients with single or multiple primary melanoma
    L Pastorino
    Department of Oncology, Biology and Genetics Medical Genetics Service, University of Genoa, Genoa, Italy
    Pigment Cell Melanoma Res 21:700-9. 2008
    ..The high frequency of CDKN2A mutations in our MPM cases, independent of their family history, is of relevance to genetic counseling and testing in our population...
  24. pmc Association of MC1R variants and host phenotypes with melanoma risk in CDKN2A mutation carriers: a GenoMEL study
    F Demenais
    INSERM U946, Fondation Jean Dausset CEPH, 27 rue Juliette Dodu, 75010 Paris, France
    J Natl Cancer Inst 102:1568-83. 2010
    ..However, investigation of the associations of both MC1R variants and host phenotypes with melanoma risk has been limited...
  25. ncbi A common variant on chromosome 9p21 affects the risk of myocardial infarction
    Anna Helgadottir
    deCODE Genetics, Sturlugata 8, IS 101 Reykjavik, Iceland
    Science 316:1491-3. 2007
    ..64 times as great as that of noncarriers. The corresponding risk is 2.02 times as great for early-onset cases. The population attributable risk is 21% for MI in general and 31% for early-onset cases...
  26. pmc The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis
    Barbara Herkert
    Theodor Boveri Institute and 2 Rudolf Virchow Center, University of Wurzburg, D 97070 Wurzburg, Germany
    J Cell Biol 188:905-18. 2010
    Oncogenic stress induces expression of the alternate reading frame (Arf) tumor suppressor protein. Arf then stabilizes p53, which leads to cell cycle arrest or apoptosis...
  27. doi p16(Ink4a) overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors
    C Romagosa
    Pathology Department, Fundació Institut de Recerca, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    Oncogene 30:2087-97. 2011
    p16(Ink4a) is a protein involved in regulation of the cell cycle. Currently, p16(Ink4a) is considered a tumor suppressor protein because of its physiological role and downregulated expression in a large number of tumors...
  28. pmc Tobacco smoking and increased risk of death and progression for patients with p16-positive and p16-negative oropharyngeal cancer
    Maura L Gillison
    The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA
    J Clin Oncol 30:2102-11. 2012
    ..Tobacco smoking is associated with oropharynx cancer survival, but to what extent cancer progression or death increases with increasing tobacco exposure is unknown...
  29. ncbi Defining the molecular basis of Arf and Hdm2 interactions
    B Bothner
    Department of Structural Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Mol Biol 314:263-77. 2001
    ..In response to hyperproliferative signals, p14(Arf) stabilizes p53 by binding to Hdm2 and inhibits the ubiquitination and subsequent proteosome-dependent ..
  30. ncbi p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice
    Beatrice Eymin
    Groupe de Recherche sur le Cancer du Poumon, EA 2021, Equipe INSERM 9924, Institut Albert Bonniot, La Tronche, France
    Oncogene 22:1822-35. 2003
    Until recently, the ability of ARF (human p14(ARF), murine p19(ARF)) tumour-suppressor protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli was related to its ability to stabilize p53 through the ..
  31. pmc Genome-wide association study identifies three loci associated with melanoma risk
    D Timothy Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Clinical Centre at Leeds, St James s University Hospital, Leeds, UK
    Nat Genet 41:920-5. 2009
    ..Despite wide variation in allele frequency, these genetic variants show notable homogeneity of effect across populations of European ancestry living at different latitudes and show independent association to disease risk...
  32. pmc High Frequency of p53/MDM2/p14ARF Pathway Abnormalities in Relapsed Neuroblastoma
    Jane Carr-Wilkinson
    Department of Cellular Pathology, Northern Institute for Cancer Research, Royal Victoria Infirmary, Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
    Clin Cancer Res 16:1108-18. 2010
    ..p53 mutations are rare in diagnostic neuroblastomas, but we have previously reported inactivation of the p53/MDM2/p14(ARF) pathway in 9 of 17 (53%) neuroblastoma cell lines established at relapse.
  33. pmc Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk
    Amy L Sherborne
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 42:492-4. 2010
    ..3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 x 10(-11)), irrespective of cell lineage...
  34. pmc p16 positive oropharyngeal squamous cell carcinoma:an entity with a favorable prognosis regardless of tumor HPV status
    James S Lewis
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Surg Pathol 34:1088-96. 2010
    ..Many recommend use of both p16 immunohistochemistry and HPV in situ hybridization (ISH)...
  35. ncbi Significant role for p16INK4a in p53-independent telomere-directed senescence
    Jacqueline J L Jacobs
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021 USA
    Curr Biol 14:2302-8. 2004
    ..attrition in primary human fibroblasts induces replicative senescence accompanied by activation of the p53 and p16(INK4a)/RB tumor suppressor pathways...
  36. pmc Expression of senescence-related genes in human corneal endothelial cells
    Zhenhua Song
    State Key Lab Cultivation Base, Shandong Provincial Key Lab of Ophthalmology, Shandong Eye Institute, Qingdao, China
    Mol Vis 14:161-70. 2008
    To investigate the expression of p16(INK4a), p21(WAF1/CIP1), p27(KIP1), and p53 in human corneal endothelial cell (HCEC) senescence ex vivo at various donor ages.
  37. ncbi CDKN2A as a uveal and cutaneous melanoma susceptibility gene
    Caroline Kannengiesser
    Service de Genetique, Institut Gustave Roussy, Villejuif, France
    Genes Chromosomes Cancer 38:265-8. 2003
    ..Immunohistochemistry performed on the UM tissue block revealed loss of CDKN2A protein staining in tumor cells. These observations demonstrate that CDKN2A is also a UM susceptibility gene...
  38. ncbi p16INK4A and p14ARF expression pattern by immunohistochemistry in human papillomavirus-related cervical neoplasia
    Jian Liu Wang
    Department of Molecular Medicine, Karolinska Institute, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
    Mod Pathol 18:629-37. 2005
    ..b>p16INK4A and possibly p14ARF have been proposed as putative surrogate biomarkers that would allow identification of ..
  39. ncbi Familial melanoma, pancreatic cancer and germline CDKN2A mutations
    Alisa M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7236, USA
    Hum Mutat 23:630. 2004
    ..R24P) and c.159G>C (p.M53I) families. Further research utilizing individual-specific data will be required to determine whether these patterns represent etiologic differences or incomplete reporting of cancer and mutation data...
  40. ncbi Stability of nucleolar versus non-nucleolar forms of human p14(ARF)
    Helen Rodway
    Cancer Research UK, London Research Institute, Lincoln s Inn Fields, London, WC2A 3PX, UK
    Oncogene 23:6186-92. 2004
    Fusion proteins containing the amino-terminal domain of human p14(ARF) linked to green fluorescent protein are able to bind MDM2 and stabilize p53 without localization in the nucleolus...
  41. ncbi Increased expression of senescence-associated cell cycle inhibitor p16INK4a in deteriorating renal transplants and diseased native kidney
    Anette Melk
    Division of Nephrology and Transplantation Immunology, Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Transplant 5:1375-82. 2005
    ..Somatic cell limitations could contribute to deterioration in aging and disease states. Since expression of p16(INK4a), a cell cycle inhibitor associated with somatic cell senescence in vitro, is induced in aged kidney, we studied ..
  42. pmc Comprehensive analysis of CDKN2A (p16INK4A/p14ARF) and CDKN2B genes in 53 melanoma index cases considered to be at heightened risk of melanoma
    K Laud
    Service de Genetique, Institut Gustave Roussy, 94800 Villejuif, France
    J Med Genet 43:39-47. 2006
    Comprehensive analysis of the 9p21 locus including the CDKN2A, ARF, and CDKN2B genes in 53 individuals from melanoma index cases considered to be at heightened risk of melanoma.
  43. ncbi A novel type of deletion in the CDKN2A gene identified in a melanoma-prone family
    Stian Knappskog
    Department of Medicine, Section of Oncology, Haukeland University Hospital, N 5021 Bergen, Norway
    Genes Chromosomes Cancer 45:1155-63. 2006
    ..Here, the defect was identified through detection of a truncated p14(ARF) mRNA and loss of p16(INK4a) mRNA expression from the affected allele...
  44. pmc NSAIDs modulate CDKN2A, TP53, and DNA content risk for progression to esophageal adenocarcinoma
    Patricia C Galipeau
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
    PLoS Med 4:e67. 2007
    ..We aimed to evaluate somatic genetic abnormalities with NSAIDs as predictors of EA in a prospective cohort study of patients with BE...
  45. ncbi hAda3 regulates p14ARF-induced p53 acetylation and senescence
    P Sekaric
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Oncogene 26:6261-8. 2007
    Acetylation is thought to be a key event for p53 activation. We demonstrate that p14ARF-induced senescence of human mammary epithelial cells (MEC) is associated with p53 acetylation and requires hAda3, a component of histone ..
  46. pmc Genome-wide association study identifies five susceptibility loci for glioma
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Nat Genet 41:899-904. 2009
    ..3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor...
  47. doi Methylation of p16 CpG island associated with malignant progression of oral epithelial dysplasia: a prospective cohort study
    Jie Cao
    Peking University School and Hospital of Stomatology, Beijing, China
    Clin Cancer Res 15:5178-83. 2009
    Inactivation of p16 gene by CpG methylation is a frequent event in oral epithelial dysplasia...
  48. pmc Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses
    Delin Chen
    Institute for Cancer Genetics, and Department of Pathology and Cell Biology College of Physicians and Surgeons, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA
    Nature 464:624-7. 2010
    The tumour suppressor ARF is specifically required for p53 activation under oncogenic stress...
  49. pmc Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression
    Michael S Cunnington
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS Genet 6:e1000899. 2010
    ..Our study suggests that modulation of ANRIL expression mediates susceptibility to several important human diseases...
  50. pmc p14ARF genetic polymorphisms and susceptibility to second primary malignancy in patients with index squamous cell carcinoma of the head and neck
    Yang Zhang
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 117:1227-35. 2011
    b>p14(ARF) , an alternate reading frame (ARF) product of the cyclin-dependent kinase inhibitor 2A locus, plays a critical role in crosstalk between the tumor protein 53 (p53) and retinoblastoma (Rb) pathways and in cellular anticancer ..
  51. doi The correlations between alteration of p16 gene and clinicopathological factors and prognosis in squamous cell carcinomas of the buccal mucosa
    Yuying Dong
    Department of Oral and Maxillofacial Surgery, School of Stomatology, Hebei Medical University, Shijiazhuang, Hebei, China
    J Oral Pathol Med 41:463-9. 2012
    To evaluate relationships between the alteration of p16 gene and the clinical status and prognosis of the patients with squamous cell carcinoma of the buccal mucosa.
  52. doi p16 expression is not associated with human papillomavirus in urinary bladder squamous cell carcinoma
    Riley E Alexander
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mod Pathol 25:1526-33. 2012
    ..the possible role of HPV in the development of squamous cell carcinoma of the urinary bladder and to determine if p16 expression could serve as a surrogate marker for HPV in this malignancy...
  53. pmc A novel RT-PCR method for quantification of human papillomavirus transcripts in archived tissues and its application in oropharyngeal cancer prognosis
    Ge Gao
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
    Int J Cancer 132:882-90. 2013
    ..Besides HPV16, three other HPV types were also detected, including 33, 35 and 18. Furthermore, HPV and p16 had essentially identical expression signatures, and both HPV and p16 were prognostic biomarkers for the prediction ..
  54. pmc Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population
    Marco Alberto Gamboa-Meléndez
    Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas de la Universidad Nacional Autónoma de México e Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
    Diabetes 61:3314-21. 2012
    ..Lack of association for the rest of the variants may have resulted from insufficient power to detect smaller allele effects...
  55. ncbi Alterations of the p16(ink4a) gene in resected nonsmall cell lung tumors and exfoliated cells within sputum
    Jung Ta Chen
    Department of Pathology, Taichung Veterans General Hospital, Republic of China
    Int J Cancer 98:724-31. 2002
    ..5% of 107 resected nonsmall cell lung cancers (NSCLCs), suggesting that the p16(INK4a) gene is frequently inactivated in primary NSCLC...
  56. ncbi Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1
    Kevin S Smith
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mol Cell 12:393-400. 2003
    Loss-of-function alterations of INK4A are commonly observed in lymphoid malignancies, but are consistently absent in pre-B cell leukemias induced by the chimeric oncoprotein E2a-Pbx1 created by t(1;19) chromosomal translocations...
  57. ncbi The hypermethylation and protein expression of p16 INK4A and DNA repair gene O6-methylguanine-DNA methyltransferase in various uterine cervical lesions
    Zhenhua Lin
    Department of Pathology, Korea University College of Medicine, Seoul, South Korea
    J Cancer Res Clin Oncol 131:364-70. 2005
    This study is aimed at investigating the significance of gene promoter methylation status and protein expression of p16 INK4A and O6-methylguanine-DNA methyltransferase (MGMT) in the various uterine cervical lesions.
  58. pmc Distinct E2F-mediated transcriptional program regulates p14ARF gene expression
    Hideyuki Komori
    Human Gene Sciences Center, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo, Japan
    EMBO J 24:3724-36. 2005
    The tumor suppressor p14(ARF) gene is induced by ectopically expressed E2F, a positive regulator of the cell cycle. The gene is expressed at low levels in normally growing cells in contrast to high levels in varieties of tumors...
  59. doi Cyclin-dependent kinase 1 expression is inhibited by p16(INK4a) at the post-transcriptional level through the microRNA pathway
    W W Chien
    Universite Claude Bernard Lyon 1, CNRS UMR 5239 ENS HCL, Faculté de médecine Lyon Sud, Oullins, France
    Oncogene 30:1880-91. 2011
    The p16(INK4a) protein regulates cell cycle progression mainly by inhibiting the activity of G1-phase cyclin-dependent kinases (CDKs) 4 and 6, the subsequent retinoblastoma protein (pRb) phosphorylation and E2F transcription factor ..
  60. doi A comprehensive analysis of p16 expression, gene status, and promoter hypermethylation in surgically resected non-small cell lung carcinomas
    William Sterlacci
    Institute for Pathology, Academic Teaching Hospital Feldkirch, Affiliation of the Medical University Innsbruck, Carinagasse, Feldkirch, Austria
    J Thorac Oncol 6:1649-57. 2011
    The role of p16 is gaining importance in non-small cell lung cancer (NSCLC) because of epigenetic therapy options...
  61. ncbi A single nucleotide polymorphism in the 3'untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare
    R Kumar
    Department of Biosciences, Center for Nutrition and Toxicology, Karolinska Institute, Novum, Huddinge, Sweden
    Int J Cancer 95:388-93. 2001
    ..CDKN2A gene in a set of 44 sporadic primary melanomas, which had been earlier analysed for mutations in the CDKN2A (p16/p14(ARF)) gene...
  62. pmc Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma
    Noriyoshi Fukushima
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 160:1573-81. 2002
    ..We have previously shown that the preproenkephalin (ppENK) and p16 genes are aberrantly methylated in pancreatic adenocarcinoma...
  63. ncbi Expression of the p16INK4A/Cdkn2a gene is prevalently downregulated in human pheochromocytoma tumor specimens
    Peter Muscarella
    Department of Surgery, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Gene Expr 14:207-16. 2008
    ..development, but there is a paucity of data regarding secondary molecular events, such as downregulation of the p16INK4A/Cdkn2a gene (hereafter p16), contributing to pheochromocytoma tumorigenesis...
  64. ncbi Downregulation of DeltaNp63alpha in keratinocytes by p14ARF-mediated SUMO-conjugation and degradation
    Maria Vivo
    Dipartimento di Biologia Strutturale e Funzionale, Universita di Napoli Federico II, Naples, Italy
    Cell Cycle 8:3545-51. 2009
    The tumor suppressor p14(ARF) inhibits cell growth in response to oncogenic stress in a p53-dependent and independent manner. However, new physiologic roles for ARF activation have been proposed...
  65. doi Immunostaining for p16INK4a used as a conjunctive tool improves interobserver agreement of the histologic diagnosis of cervical intraepithelial neoplasia
    Lars Christian Horn
    Institute of Pathology, University of Leipzig, Germany
    Am J Surg Pathol 32:502-12. 2008
    ..Overexpression of the cyclin-dependent kinase inhibitor p16INK4a, a cell cycle regulating protein, has been shown to be strongly correlated with dysplastic lesions of the cervix ..
  66. pmc Linkage and association study of late-onset Alzheimer disease families linked to 9p21.3
    S Zuchner
    Miami Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Ann Hum Genet 72:725-31. 2008
    ..003, genotype-PDT p = 0.014). We conclude that CDKN2A is a promising new candidate gene potentially contributing to AD susceptibility on chromosome 9p...
  67. pmc Large CTG repeats trigger p16-dependent premature senescence in myotonic dystrophy type 1 muscle precursor cells
    Anne Bigot
    Universite Pierre et Marie Curie Paris 6, UMR 787, Paris, France
    Am J Pathol 174:1435-42. 2009
    ..We demonstrate that an abnormal accumulation of p16 is responsible for this defect because the abolition of p16 activity overcomes early growth arrest and restores an ..
  68. doi Tumor suppressor p16 INK4a: Downregulation of galectin-3, an endogenous competitor of the pro-anoikis effector galectin-1, in a pancreatic carcinoma model
    Hugo Sanchez-Ruderisch
    Medizinische Klinik m S Hepatologie und Gastroenterologie, Charite Universitatsmedizin Berlin, Germany
    FEBS J 277:3552-63. 2010
    The tumor suppressor p16(INK4a) has functions beyond cell-cycle control via cyclin-dependent kinases...
  69. ncbi Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa
    Keizo Kato
    Department of Oral and Maxillofacial Sciences, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu, 501 1194, Japan
    J Cancer Res Clin Oncol 132:735-43. 2006
    ..Recent studies have shown roles of promoter hypermethylation of tumor suppressor genes, including p16 and MGMT, in several types of cancers...
  70. ncbi INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions
    Eduardo T Cánepa
    Laboratorio de Biologia Molecular, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
    IUBMB Life 59:419-26. 2007
    ..The members of INK4 family, comprising p16(INK4a), p15(INK4b), p18(INK4c), and p19(INK4d), block the progression of the cell cycle by binding to either Cdk4 or ..
  71. doi Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck
    Pernille Lassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Noerrebrogade 44, DK 8000 Aarhus C, Denmark
    J Clin Oncol 27:1992-8. 2009
    ..Viral infection is closely correlated with expression of p16(INK4A) in these tumors...
  72. ncbi The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha ) and inhibits HIF-1-mediated transcription
    K Fatyol
    Department of Biochemistry, Loma Linda University, Loma Linda, California 92350, USA
    J Biol Chem 276:28421-9. 2001
    ..Here we show that an important tumor suppressor protein, p14ARF (alternative reading frame product of the INK4A locus) can directly inhibit the transcriptional activity of HIF-1 by sequestering ..
  73. ncbi Patterns of gene promoter methylation in squamous cell cancer of the head and neck
    Masayuki Hasegawa
    Department of Cancer Cell Biology, Harvard School of Public Health, Boston, Massachusetts, MA 02115, USA
    Oncogene 21:4231-6. 2002
    ..characteristics, especially alcohol consumption and tobacco smoking, we examined promoter methylation of the p16(INK4a), DAP-kinase, E-Cadherin, and RASSF1A genes using methylation-specific PCR (MSP) in 80 patients...
  74. ncbi Predictive significance of the alterations of p16INK4A, p14ARF, p53, and proliferating cell nuclear antigen expression in the progression of cervical cancer
    Jian Liu Wang
    Department of Molecular Medicine, Center for Molecular Medicine, Karolinska Institute, Cancer Center Karolinska, Karolinska University Hospital, Stockholm, Sweden
    Clin Cancer Res 10:2407-14. 2004
    The purpose of this research was to evaluate the clinical significance of p16INK4A, p14ARF, p53, and proliferating cell nuclear antigen (PCNA) expression in tumor progression of cervical cancer.
  75. doi PPAR{gamma} accelerates cellular senescence by inducing p16INK4{alpha} expression in human diploid fibroblasts
    Qini Gan
    Research Center on Aging, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100083, People s Republic of China
    J Cell Sci 121:2235-45. 2008
    ..in the inhibition of cell growth by promoting cell-cycle arrest, and PPARgamma activation induces the expression of p16(INK4alpha) (CDKN2A), an important cell-cycle inhibitor that can induce senescence...
  76. pmc Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
    Hana Lango
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 57:3129-35. 2008
    ..Here, we assess the ability of 18 confirmed type 2 diabetes variants to differentiate between type 2 diabetic case and control subjects...
  77. pmc Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry
    Marilyn C Cornelis
    Harvard School of Public Health, Channing Laboratory, Boston, MA 02115, USA
    Ann Intern Med 150:541-50. 2009
    ..Genome-wide association studies have identified novel type 2 diabetes loci, each of which has a modest impact on risk...
  78. doi Aberrant de novo methylation of the p16INK4A CpG island is initiated post gene silencing in association with chromatin remodelling and mimics nucleosome positioning
    Rebecca A Hinshelwood
    Cancer Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, NSW 2010, Australia
    Hum Mol Genet 18:3098-109. 2009
    ..The tumour suppressor gene p16(INK4A) is inactivated in association with CpG island methylation during neoplastic progression in a variety of cancers, ..
  79. doi The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I
    Frédéric Lessard
    Cancer Research Centre, Department of Molecular Biology, Medical Biochemistry, and Pathology of Laval University, CHUQ Research Centre, Quebec, Quebec, Canada
    Mol Cell 38:539-50. 2010
    The p14/p19(ARF) (ARF) product of the CDKN2A gene displays tumor suppressor activity both in the presence and absence of p53/TP53...
  80. pmc Identification and characterization of Bmi-1-responding element within the human p16 promoter
    Sha Meng
    Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen 518055, China
    J Biol Chem 285:33219-29. 2010
    ..One important pathway regulated by Bmi-1 is that involving two cyclin-dependent kinase inhibitors, p16(Ink4a) and p19(Arf), as Bmi-1 represses the INK4a locus on which they are encoded...
  81. doi Primary cilium-dependent and -independent Hedgehog signaling inhibits p16(INK4A)
    Cleo L Bishop
    Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, 4 Newark Street, London E1 2AT, UK
    Mol Cell 40:533-47. 2010
    In a genome-wide siRNA analysis of p16(INK4a) (p16) modulators, we identify the Hedgehog (Hh) pathway component SUFU and formally demonstrate that Hh signaling promotes mitogenesis by suppression of p16...
  82. ncbi Functional and physical interaction of the human ARF tumor suppressor with Tat-binding protein-1
    Alessandra Pollice
    Department of Genetics, General and Molecular Biology, University of Naples Federico II, Via Mezzocannone 8, 80134 Naples, Italy
    J Biol Chem 279:6345-53. 2004
    The p14ARF tumor suppressor is a key regulator of cellular proliferation, frequently inactivated in human cancer, whose mode of action is currently not completely understood...
  83. pmc A comparison of CDKN2A mutation detection within the Melanoma Genetics Consortium (GenoMEL)
    Mark Harland
    Division of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Cancer Centre at Leeds, St James s University Hospital, Leeds, UK
    Eur J Cancer 44:1269-74. 2008
    ..The relatively low rate of CDKN2A mutation detection is not due to failure to detect mutations and implies the existence of other high penetrance melanoma susceptibility genes...
  84. doi Abnormal expression of p16(INK4a), cyclin D1, cyclin-dependent kinase 4 and retinoblastoma protein in gastric carcinomas
    Ichiro Kishimoto
    Department of Surgery, National Hospital Organization Sagamihara Hospital, Kanagawa, Japan
    J Surg Oncol 98:60-6. 2008
    The p16(INK4a) (p16), cyclin D1, cyclin-dependent kinase (CDK) 4 and retinoblastoma (Rb) genes are components of the Rb pathway that controls the G1-S checkpoint of the cell cycle...
  85. doi MC1R variation and melanoma risk in the Swedish population in relation to clinical and pathological parameters
    Veronica Höiom
    Department of Oncology Pathology, CCK, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden
    Pigment Cell Melanoma Res 22:196-204. 2009
    ..No association was found between CDKN2A gene variants and general melanoma risk. Two new variants in the POMC gene were identified in red haired individuals without RHC alleles...
  86. ncbi Aberrant methylation of the p16 gene is frequently detected in advanced colorectal cancer
    Tetsuhiro Goto
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:275-7. 2009
    A tumor suppressor gene, p16, was found to harbor promoter hypermethylation associated with the loss of protein expression in cancer cells, suggesting that p16 inactivation due to promoter methylation was important for colorectal ..
  87. doi ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation
    L Miao
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, People s Republic of China
    Oncogene 29:711-22. 2010
    ..Using a yeast two-hybrid screen, we identified human alternate reading frame (ARF) protein as a novel interaction partner of Miz-1. The zinc-finger domain of Miz-1 is involved in its binding to ARF...
  88. ncbi Tumor suppressor p16INK4a--modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells
    Sabine Andre
    Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Germany
    FEBS J 274:3233-56. 2007
    Expression of the tumor suppressor p16(INK4a) after stable transfection can restore the susceptibility of epithelial tumor cells to anoikis...
  89. doi AML at older age: age-related gene expression profiles reveal a paradoxical down-regulation of p16INK4A mRNA with prognostic significance
    Hendrik J M de Jonge
    Division of Pediatric Oncology Hematology, Department of Pediatrics, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Blood 114:2869-77. 2009
    ..probe sets on aging could be pointed to 41 probe sets, including the tumor-suppressor gene CDKN2A (encoding p16(INK4A))...
  90. pmc Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
    T Kamijo
    Howard Hughes Medical Institute, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 95:8292-7. 1998
    The INK4a-ARF locus encodes two proteins, p16(INK4a) and p19(ARF), that restrain cell growth by affecting the functions of the retinoblastoma protein and p53, respectively...
  91. pmc Different cellular p16(INK4a) localisation may signal different survival outcomes in head and neck cancer
    N Zhao
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA
    Br J Cancer 107:482-90. 2012
    ..human papilloma infection, including direct assessment of the virus as well as an associated tumour suppressor gene p16, are considered reproducible...
  92. ncbi Alteration of the p14(ARF) gene and p53 status in human hepatocellular carcinomas
    Teruaki Ito
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    J Gastroenterol 39:355-61. 2004
    The INK4a/ARF locus encodes p16INK4a and p14ARF, both of which are crucial for two tumor suppressor pathways, retinoblastoma (RB)/p16INK4a and p53/ARF...
  93. doi Expression of p16 in non-small cell lung cancer and its prognostic significance: a meta-analysis of published literatures
    Jinlong Tong
    Medical School of Southeast University, 87 Dingjiaqiao Street, Nanjing, Jiangshu, 210009, PR China
    Lung Cancer 74:155-63. 2011
    The prognostic value of p16 for survival of patients with non-small cell lung cancer (NSCLC) remains controversial. we performed a meta-analysis of the literatures in order to clarify its impact...
  94. doi Transition of cervical carcinoma in situ to invasive cancer: role of p16 INK4a expression in progression and in recurrence
    Fernando Anschau
    Serviço Integrado de Ginecologia de Cachoeirinha e Alvorada SIGAC, Instituto de Cardiologia Fundação Universitária de Cardiologia IC FUC de Porto Alegre, Brazil
    Exp Mol Pathol 86:46-50. 2009
    To investigate the expression of p16(INK4a) in cervical carcinoma and its relation to the transition of carcinoma in situ to invasive carcinoma, and its role in recurrence of cervical lesions as well, a series of 90 patients with ..
  95. ncbi Alterations in the INK4a/ARF locus and their effects on the growth of human osteosarcoma cell lines
    Yong Bum Park
    Biology Division, National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo, Japan
    Cancer Genet Cytogenet 133:105-11. 2002
    Two different proteins, p16(INK4a) and p14(ARF), encoded by the INK4a/ARF locus play important roles in the RB and p53 pathways, respectively...
  96. ncbi High-risk melanoma susceptibility genes and pancreatic cancer, neural system tumors, and uveal melanoma across GenoMEL
    Alisa M Goldstein
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892 7236, USA
    Cancer Res 66:9818-28. 2006
    ..in the high-risk melanoma susceptibility genes CDKN2A/alternate reading frames (ARF), which encodes p16 and p14ARF, and CDK4 and to evaluate their relationship with pancreatic cancer (PC), neural system tumors (NST), and uveal ..
  97. pmc CDKN2A/p16 inactivation mechanisms and their relationship to smoke exposure and molecular features in non-small-cell lung cancer
    Kit W Tam
    Hamon Center for Therapeutic Oncology Research and Division of Biostatistics, University of Texas Southwestern Medical Center, Dallas, Texas Department of Integrative Oncology, British Columbia Cancer Agency Research Centre, Vancouver, B C, Canada Texas Scottish Rite Hospital for Children, Dallas, Texas Department of Surgery, Biochemistry, and Molecular Biology, Keck School of Medicine, USC Norris Comprehensive Cancer Center, Los Angeles, California Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington Oncology Biomarker Development, Genentech Inc, South San Francisco, California Department of Molecular and Cell Biology, Center for Systems Biology, University of Texas at Dallas, Dallas, Texas and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas
    J Thorac Oncol 8:1378-88. 2013
    CDKN2A (p16) inactivation is common in lung cancer and occurs via homozygous deletions, methylation of promoter region, or point mutations...
  98. ncbi Germline CDKN2A/p16 mutations are rare in multiple primary and familial malignant melanoma in German patients
    Ansgar Lukowsky
    J Dermatol Sci 49:163-5. 2008
  99. ncbi p16 gene methylation in colorectal cancer patients with long-term follow-up
    Silvia Veganzones-de-Castro
    Department of Clinical Analysis, Hospital Clinico San Carlos, Madrid, Spain
    Rev Esp Enferm Dig 104:111-7. 2012
    b>p16 gene plays an important role in the cell cycle regulation and is considered an important tumor suppressor gene...
  100. doi [Relationship between promoter methylation of p16, DAPK and RAR beta genes and the clinical data of non-small cell lung cancer]
    Chen ye Zhang
    Environment Epigenetic Laboratory, Institute of Environmental Health, College of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 28:23-8. 2011
    To investigate the effects of promoter methylation of p16, death-associated protein kinase (DAPK) and retinoic acid receptor-beta (RAR beta) genes on clinical data in non-small cell lung cancers, and to study the effect of smoking on the ..
  101. ncbi CDKN2A mutations in multiple primary melanomas
    J Monzon
    Institute of Medical Sciences, University of Toronto, ON, Canada
    N Engl J Med 338:879-87. 1998
    Germ-line mutations in the CDKN2A tumor-suppressor gene (also known as p16, p16INK4a, and MTS1) have been linked to the development of melanoma in some families with inherited melanoma...

Research Grants117 found, 100 shown here

  1. Melanoma in p16INK4a and p19ARF Deficient Mice
    NORMAN SHARPLESS; Fiscal Year: 2006
    ..The Ink4a/Arf locus, conserved in mouse and humans, encodes two distinct proteins, p16INK4a and p19ARF, both of which regulate critical tumor suppressor pathways, and each may play a substantive role in ..
  2. Patrick N Cunningham; Fiscal Year: 2014
    ..Preliminary data indicate that LPS-induced ARF, a model of septic renal dysfunction, depends on the action of TNF on its receptor TNFR1 in the kidney, and is ..
  3. Pathophysiology of sepsis-induced renal injury
    Pierre C Dagher; Fiscal Year: 2013
    ..It is the purpose of this proposal to explore a novel hypothesis regarding the pathophysiology of ARF and AKI in gram negative sepsis...
  4. Epigenetic Reprogramming by the Human Papillomavirus E7 Oncoprotein
    MARGARET ERIN MCLAUGHLIN-DRUBIN; Fiscal Year: 2012
    ..at markedly higher levels in HPV16 E7 expressing cells, and E7 mediated JMJD3 over- expression is critical for p16INK4A expression...
  5. Epigenetic mechanisms underlying aberrant gene expression in cancer
    Sheila Chari; Fiscal Year: 2012
    ..For this, we will employ a well-defined genetic model of cancer, the N-RASQ61K INK4a-/- mouse model of metastatic melanoma...
  6. P16 GENE FAMILY IN HEALTH AND DISEASE
    Gregory Hannon; Fiscal Year: 1999
    ..The p16 family currently contains two members, p16INK4A and p15INK4B...
  7. Lorraine J Gudas; Fiscal Year: 2014
    ..murine oral cavity carcinogenesis model, and to assess the expression of molecular markers such as cyclin D1;RAR22;p16;SFRP 1,2,4, and 5;and nanog in normal epithelial stem/progenitor cells versus "cancer stem/progenitor cells" from ..
  8. Thea D Tlsty; Fiscal Year: 2014
    ..Repression of p16INK4a activity in HMEC increases expression of the E2F1 transcription factor and, consequently, of several of its ..
  9. Pesticide Exposure and DNA Methylation in Pesticide Applicators
    JENNIFER ANN RUSIECKI; Fiscal Year: 2010
    ..promoter region methylation for four of the most commonly silenced genes in cancers of concern to this cohort, p16INK4, MGMT, CDH-1, and GSTp1...
  10. NICOLAS SCHLECHT; Fiscal Year: 2014
    ..key effector proteins, including for four panel loci downstream of the transcriptional start site of CDKN2A(p16) that, despite being hypermethylated in tumor compared to normal tissues, are associated with increased expression ..
  11. Li Shu Wang; Fiscal Year: 2014
    ..cells, which led to demethylation and reactivation of hypermethylation-silenced tumor suppressor genes such as p16. Short-term BRB intervention in colorectal cancer patients resulted in the demethylation of p16 and re-expression ..
  12. Biomarkers to Guide Treatment and Improve Survival in Oral/Oropharyngeal Cancer
    Thomas E Carey; Fiscal Year: 2012
    ..type and copy number, p53 status and expression, BCLXL expression, the epidermal growth factor receptor (EGFR), and p16. All have predictive value for response to therapy and survival in oropharynx cancers treated by induction ..
  13. Sheri L Holmen; Fiscal Year: 2016
    ..We have generated Ink4a/Arf lox/l[unreadable]x mice that express the retroviral receptor TVA specifically in melanocytes from the ..
  14. Pancreatic Cancer Management by Novel Gene Therapy &Dietary Agents
    Paul B Fisher; Fiscal Year: 2012
    ..by the development of murine models that utilize a combination of targeted KrasG12D expression in the pancreas and Ink4a/Arf deficiency to develop pancreatic intraepithelial neoplasias (PanINs), which mimic the human disease, ..
  15. Susan M Wolf; Fiscal Year: 2015
    ..known to confer increased risk of diseases other than pancreatic cancer: BRCA2 (breast &ovarian cancer), CDKN2A/p16 (malignant melanoma), and CFTR (cystic fibrosis in offspring)...
  16. Mechanisms of RelA Activation in Cancer
    Paul J Chiao; Fiscal Year: 2013
    ..event in pancreatic carcinogenesis and has been detected in 80-95% of pancreatic cancers;and inactivation of p16/Ink4a/Arf and p53 tumor suppressor genes can be identified approximately 50-75% of pancreas cancers...
  17. Chemoprevention of tobacco carcinogen-induced bladder cancer
    Harikrishna Nakshatri; Fiscal Year: 2011
    ..such as CXCL-1 and/or inactivation of tumor suppressor genes (p53, retinoblastoma, BIM, p21, RASSF1A, RUNX3, and p16INK4) through mutations or epigenetic mechanisms...
  18. Jinghua Hu; Fiscal Year: 2016
    ..Three small GTPase Arls (ADP-ribosylation factor (Arf)-like proteins), Arl3, Arl6/Bbs3, and Arl13B, have been implicated in either human ciliopathies or vertebrate ..
  19. UV damage, repair, and mutagenesis
    Gerd P Pfeifer; Fiscal Year: 2013
    ..We will attempt to identify a UVB signature in the human p16 gene of melanoma patients and a UVA signature in the BRAF gene...
  20. ATF2 in melanoma development and progression
    ZE apos EV A RONAI; Fiscal Year: 2012
    ..The cross of ATF2 mutant mice with the Tyr:N-RasQ61K INK4a-/- strain which develop metastatic melanoma, abolished melanoma development in all but 1 out of 22 mice...
  21. Repair of Clustered DNA Damages
    Yoke W Kow; Fiscal Year: 2010
    ..Familiar melanoma has been observed to be associated with CDKN2a/ARF and CDK mutations...
  22. MIKHAIL NIKIFOROV; Fiscal Year: 2016
    ..We have recently demonstrated that unlike mouse or human fibroblasts, depletion of p53 or p16INK4A tumor suppressors is not sufficient to overcome OIS in human melanocytes...
  23. HDAC6-Selective Inhibitors for Pancreatic Cancer Treatment
    Werner Tueckmantel; Fiscal Year: 2010
    ..HDAC activity in cancer cells may contribute to the epigenetic silencing of tumor suppressor genes such as p16, p21 and gelsolin...
  24. Ann Richmond; Fiscal Year: 2016
    ..in melanocytes prevents mutant Ras-mediated melanoma tumor formation in mice that have lost the tumor suppressors INK4a/ARF. Current therapies for disseminated melanoma are largely ineffective...
  25. Anthony N van den Pol; Fiscal Year: 2016
    ..Its highly attenuated nature reduces concerns relating to infection of normal brain tissue. If these experiments are successful, they will form a major advance toward clinical trials for metastatic melanoma in humans. ..
  26. Martin McMahon; Fiscal Year: 2016
    ..In Aim 2 we will test the hypothesis that the loss of the Ink4a/Arf, Pten or Trp53 tumor suppressor genes can influence the response of KRasG12D- or BRafV600E-induced lung tumors ..
  27. Comparative Effectiveness in Genomic Medicine
    Katrina Armstrong; Fiscal Year: 2009
    ..cancer risk screening and prevention;(3) personalized treatment for non small cell lung cancer;and (4) CDKN2A/p16 testing and adherence to melanoma prevention behaviors...
  28. Comparative Effectiveness in Genomic Medicine
    Katrina Armstrong; Fiscal Year: 2010
    ..cancer risk screening and prevention;(3) personalized treatment for non small cell lung cancer;and (4) CDKN2A/p16 testing and adherence to melanoma prevention behaviors...
  29. Melanocyte Survival and Transformation: Hypoxia & P13 Kinase/Akt/mTOR Signaling
    Marianne Broome Powell; Fiscal Year: 2010
    ..and sporadic melanomas have identified a number of oncogenic alterations including Ras, B-Raf, PTEN, Akt, and Ink4a/Arf...
  30. A new approach to identify rare genetic variants influencing melanoma risk
    Fabienne Lesueur; Fiscal Year: 2013
    ....
  31. Genetic Epidemiology of Young-Onset Pancreatic Cancer
    Robert R McWilliams; Fiscal Year: 2010
    ..This proposed research is 100% relevant to pancreatic cancer. ..
  32. Somatic genetic predictors of response to therapy in metastatic melanoma
    Katherine L Nathanson; Fiscal Year: 2011
    ..and recent data suggest that genetic changes in three interacting pathways (RAS signaling [MAPK, PI3K/Akt], p16-CDK4-Rb and p53) play important roles in melanoma...
  33. The temporal epigenomic program of Barrett's neoplastic progression
    Stephen J Meltzer; Fiscal Year: 2013
    ..Tumor suppressor genes affected by hypermethylation at various stages of BN include p16, p14, E-cadherin, APC, and others...
  34. Novel Therapeutic Approach for Sepsis: Blocking the Vascular Response to Cytokine
    ALAN L MUELLER; Fiscal Year: 2012
    ..Dr. Li and colleagues further determined that ARF6 can be blocked through inhibition of its ARF-GEF, cytohesin2/ARNO, using a small molecule inhibitor, NAV838. Dr...
  35. Peter A Kanetsky; Fiscal Year: 2016
    ..GenoMEL is poised to address this knowledge gap. ..
  36. Ze ev A Ronai; Fiscal Year: 2015
    ..A genetic N-RAS/Ink4a mouse melanoma model established the oncogenic role of the transcription factor ATF2 in melanoma...
  37. Hensin Tsao; Fiscal Year: 2016
    ....
  38. ER-to-cell surface transport and signal regulation of GPCRs
    Guangyu Wu; Fiscal Year: 2013
    ..a novel function for GGAs [monomeric Golgi-localizing, 3-adaptin ear domain homology, ADP ribosylation factor (ARF)-binding proteins]...
  39. MATTHEW WAYNE VANBROCKLIN; Fiscal Year: 2016
    ..Expression of mutant c- KIT (L576P) in mouse melanocytes in vivo in the context of Ink4a/Arf loss resulted in the development of melanoma in one-quarter of the mice with a mean latency of 120 days...
  40. Generation of an UV-dependent Mouse Model of Melanoma
    Lidia Kos; Fiscal Year: 2010
    ..Genetic studies have identified INK4a/ARF at chromosome 9p21 as a melanoma susceptibility locus...
  41. Cellular and Molecular Mechanisms in Periventricular Heterotopia
    Volney L Sheen; Fiscal Year: 2013
    ..b>ARF activation is required during the assembly of protein coats for vesicle budding...
  42. James H Prestegard; Fiscal Year: 2014
    ..However, the way in which the biochemical tranformations of ARF are coordinated with carrier formation, and the structural aspects of membrane association and protein-protein ..
  43. Role of MDM2 in Cell Proliferation and Tumorigenesis
    Zhi Xiong Jim Xiao; Fiscal Year: 2010
    ..Specific Aim 2 is to investigate the roles of MDMx and tumor suppressor protein ARF in modulation of MDM2-Rb and Specific aim 3 is to examine the role of MDM2-Rb in tumorigenesis in vivo...
  44. ARF GTPase regulation of prostate tumorigenesis: spheroid and in vivo approaches
    DAVID MICHAEL BRYANT; Fiscal Year: 2013
    ..With this award, Dr. Bryant will examine the ADP-ribosylation factor (ARF) GTPase family and their regulatory molecules (the ARF 'regulome') in control of polarity during prostate ..
  45. Todd A Waldman; Fiscal Year: 2016
    ..as checkpoints, and are encoded by several of the most commonly mutated tumor suppressor genes such as p53 and p16INK4a. PTEN is one of the most commonly inactivated tumor suppressor genes in human cancer...
  46. KENNETH R TETER; Fiscal Year: 2016
    ..on CTA1;(ii) demonstrate the refolding function of the translocase complex and examine its potential effect on ARF-stimulated toxin activity;and (iii) identify a broader range of toxins and endogenous ERAD substrates for the ..
  47. BEVERLY MARIE EMERSON; Fiscal Year: 2015
    ..which protects genes from adjacent heterochromatin domains, results in transcriptional inactivation of the p16INK4a tumor suppressor gene, which is a frequent target of epigenetic silencing in many types of human cancers and ..
  48. GLORIA HUEI TING SU; Fiscal Year: 2015
    ..Oncogene KRAS and tumor-suppressor genes p16 and SMAD4 are frequently mutated in human PDA...
  49. MOLECULAR PROGRESSION MODEL FOR HNSCC
    David Sidransky; Fiscal Year: 2012
    ..Specific tumor suppressor genes, including p14 and p16, and proto-oncogenes, including p63, have been identified as critical in oral cancer development...
  50. M James You; Fiscal Year: 2015
    ..Inactivation of PTEN, INK4a and ARF tumor suppressor genes is among the most frequent genetic events in T-ALL...
  51. ARF MDM2 P53 TUMOR SUPPRESSION PATHWAY
    Yanping Zhang; Fiscal Year: 2005
    ..Along withp53, the ARF-INK4a locus is one of the two most frequently altered loci in human cancer. Functionally, p16INK4a inhibits the activity of cyclin D-dependent kinases (CDK4 and CDK6), thereby maintaining the retinoblastoma ..
  52. Irene Orlow; Fiscal Year: 2014
    ..We plan to sequence the CDKN2A/p16 gene in 3580 DNA samples from buccal brushes that has been whole-genome amplified with the GenomePlex(R) kit, and ..
  53. ARF regulators in endocytic transport
    Victor W Hsu; Fiscal Year: 2013
    ..The ARF small GTPases are, in turn, regulated by guanine nucleotide exchange factors (GEFs) that catalyze ARF activation ..
  54. High-throughput analysis of pancreatic cancer mutations
    Scott E Kern; Fiscal Year: 2012
    ..We identified frequent mutations in the p16, SMAD4, BRCA2, and other genes, and this line of research is now reaching a period of rapid development, for the ..
  55. Targeted Gene Knockouts of p14ARF and p16INK4a
    Utz Herbig; Fiscal Year: 2005
    ..This locus encodes the two tumor suppressor proteins p16 INK4a and p14 ARF...
  56. STRUCTURAL KINETIC STUDIES BY NUCLEAR MAGNETIC RESONANCE
    Alfred Redfield; Fiscal Year: 1999
    ..b>ARF 1 is a small G protein implicated in formation and regulation of non-clathrin coated vesicles...
  57. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2012
    ..1/Kir3.4 heteromers through the Arf-6 GTPase dependent pathway...
  58. SAMI FOUAD NOUJAIM; Fiscal Year: 2014
    ..1/Kir3.4 heteromers through the Arf-6 GTPase dependent pathway...
  59. Alvaro Puga; Fiscal Year: 2015
    ..Hypermethylation of the promoter of the tumor suppressor p16ink4a gene has been found in chromium-exposed workers who developed lung cancer, although p16ink4a promoter methylation ..
  60. Tumor Microenvironment Interactions in Brain Tumors
    Eric C Holland; Fiscal Year: 2010
    ..In Aim 2 we will determine whether loss of the known glioma tumor suppressors (INK4a, Arf, PTEN) will promote the incorporation and contribution of recruited cells to the tumor proper...
  61. Oxidative stress and melanoma chemoprevention
    Douglas Grossman; Fiscal Year: 2007
    ..Individuals with a mutant CDKN2A (p16) allele have an 80% lifetime-risk of developing melanoma...
  62. Evaluation of novel FoxM1 inhibitors against liver cancer
    Andrei L Gartel; Fiscal Year: 2012
    ..we will use a Diethylnitrosamine (DEN)/Phenobarbital (PB) liver tumor induction protocol in male mice and a new ARF-/- Rosa-26 FoxM1b TG mouse model of aggressive metastatic liver cancer...
  63. Zheng Dong; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Kidney injury by ischemia leads to acute renal failure (ARF), a major kidney disease associated with high mortality...
  64. Mouse Models of Non-Syndromic Cardiac Progeria
    Ali J Marian; Fiscal Year: 2012
    ..expression of established markers of senescence, namely senescence-associated 2-galactosidase (S-A 2-Gal), p16INK4a (Cdkn2a), P19, p21WAF1/CIP1, telomere attrition and telomerase activity...
  65. Genomic approaches to inner ear hair cell regeneration
    Michael Lovett; Fiscal Year: 2010
    ..this process (again by mRNA and micro-RNA Next Gen sequencing) by comparing mouse utricles at birth (P0) and at P16 and after antibiotic killing of the hair cells at both these time points...
  66. Study on the intracellular Network of TBX3
    Taosheng Huang; Fiscal Year: 2010
    ..TBX3 can also inhibit the expression of the p14ARF gene, a tumor suppressor and an inhibitor of MDM2-mediated degradation of p53...
  67. Christopher E Turner; Fiscal Year: 2016
    ..of Rho family GTPase signaling and focal adhesion dynamics by establishing a local signaling network comprising the ARF GAP PKL/GIT2, the guanine nucleotide exchange factor Vav2 and the tyrosine phosphatase PTP-PEST...
  68. Vimla Band; Fiscal Year: 2015
    ..compared to rapid transit through cell cycle in immortal human mammary epithelial cells (hMECs) that lack p16;and co-overexpression of Ecd with activated Ras induced a dramatic hyper-proliferation and aberrant branching of ..
  69. Protein Kinase C in the Repair of Cellular Functions
    Grazyna Nowak; Fiscal Year: 2013
    ..events and regulatory mechanisms involved in: 1) the loss of renal functions associated with acute renal failure (ARF) as caused by ischemia/reperfusion and 2) the repair of renal functions following ARF...
  70. Lorraine J Gudas; Fiscal Year: 2014
    ..g. p16, cyclin D1, cyclooxygenase-2, EGFR, phosphoSTAT3, and cell proliferation (BrdU or PCNA)...
  71. The in vivo role of the mitochondrial p53 cell death program
    UTE MARTHA MOLL; Fiscal Year: 2013
    ..wild-type p53 in a cMyc-driven mouse model of Burkitt's lymphoma shows effective tumor killing of p53-null, ARF-null and p53-mutant tumor cells in vivo...
  72. Richard A Zager; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): A seeming paradox exists during the maintenance phase of acute renal failure (ARF)...
  73. ELIZABETH PATRICIA CROWE; Fiscal Year: 2015
    ..The selective clearance of cells expressing the senescence biomarker p16INK4a in a mouse model of premature aging delayed and alleviated age-related pathologies in several organ systems...
  74. Epigenetic Regulation of Cell and Tissue Aging
    Nikolai A Timchenko; Fiscal Year: 2013
    ..The RB/p16INK4a, but not p53, pathway regulates the senescence of human melanocytes in culture and melanocytic nevi in vivo...
  75. Sean J Morrison; Fiscal Year: 2016
    ..In preliminary studies we have discovered that the Alternative reading frame (Arf) at the Ink4a/Arf locus is not detectable in fetal and young adult stem cells but increases in ..
  76. Ming Ming Zhou; Fiscal Year: 2015
    ..observed in our study markedly elevated expression of ANRIL, CBX7 and EZH2 and a corresponding decrease in p16Ink4a expression in prostate cancer as compared to normal prostate epithelial cells...
  77. Michael Wargovich; Fiscal Year: 2014
    ..for changes in HDACs that associate with the promoter region of RXRa, RAR[unreadable], hMLH1, p14arf, and p16INK4a and compare this activity with other known inhibitors of HDACs...
  78. Michael R Green; Fiscal Year: 2016
    ..Consistent with this hypothesis, inactivation of genes known to promote senescence, such as TP53 and CDKN2A (p16INK4a/p14ARF), can cooperate with BCR-ABL in mouse models of CML, and CDKN2A deletions are frequently found in patients ..
  79. Parvovirus RNA Processing and Gene Expression Strategies
    David J Pintel; Fiscal Year: 2013
    ..1. Unlike AAV2, AAV5 Rep-encoding P19-generated transcripts are polyadenylated within the central intron and therefore not spliced, precluding an AAV2-..
  80. DEAN YAW LI; Fiscal Year: 2016
    ..MYD88 binds to ARNO, an ARF-GEF that activates the small GTPase ARF6...
  81. Yuanyuan Li; Fiscal Year: 2014
    ..transgenic mouse models, 2) evaluate specific epigenetic-controlled key genes such as hTERT, ER[unreadable] and p16INK4a in response to maternal dietary BSp or GE treatment and 3) assess the impact of maternal BSp or GE diet on ..
  82. AC1 and AC8 as Mediators of the Dendritic Response to Ethanol in a Model of FASD
    Laura Susick; Fiscal Year: 2013
    ..In Aim 1, P5-7 pups (WT and DKO) will be treated with ethanol and striatal neurons will be analyzed at P14 and P30 for soma size, dendritic length, dendritic branching, and spine density...
  83. Acute Renal Failure: An Endotoxin Hyper-Responsive State
    Richard A Zager; Fiscal Year: 2013
    ..g., TNF-1) / chemokine (e.g., MCP-1) production which can worsen the severity of acute renal failure (ARF). With renal venous cytokine efflux, extra-renal injury may also result...
  84. DUSANKA DANIELLE DERETIC; Fiscal Year: 2016
    ..To elucidate the architecture of the targeting complex, which is comprised of the small GTPases Arf4 and Rab11, the Arf GAP ASAP1, and the Arf/Rab11 effector FIP3, and determine its mode of interaction with rhodopsin at the trans-Golgi ..
  85. CLAUDIA KATHARINA PETRITSCH; Fiscal Year: 2016
    ..A mutant, activated form of BRAF, BRAFVE, and concomitant homozygous deletion of CDKN2A, encoding p16, have been found in a significant fraction of pediatric MA...
  86. MICHAEL FRANCIS BEERS; Fiscal Year: 2016
    ..Nedd4-2 WW domains, proSP-C monoubiquitination, and the adapter protein Golgi-associated, ?-adaptin homologues, Arf-binding protein 3 (GGA3) in anterograde trafficking of proSP-C...
  87. Maryann Obiorah; Fiscal Year: 2014
    ..during ages that correspond to the third trimester of human development (postnatal day 7 - P7), prepubescence (P14), and adolescence (P21)...
  88. Howard D Strickler; Fiscal Year: 2016
    ..HPV namely, the cobas HPV Test and Hybrid Capture 2 (HC2), (ii) cellular markers of E6 activity / proliferation (p16/ki-67 cytology;CINtec+), (iii) cellular markers of aberrant S-phase induction (MCM2/Top2A cytology;BD ProExC), (iv) ..
  89. BETTINA R WINCKLER; Fiscal Year: 2016
    ..is that vertebrate neurons express neuronal-specific proteins in their endosomes (in particular NEEP21/Nsg-1 and P19/Nsg-2) that control the endosomal trafficking of crucial neuronal membrane proteins, such as receptors important in ..
  90. Pumin Zhang; Fiscal Year: 2016
    ..On the other hand, when p53 is inactivated, aneuploidy induces robust senescence and p16 expression...
  91. Lorraine C Santy; Fiscal Year: 2016
    ..The overall objective of this application is to determine the molecular details of this cytohesin-dependent Arf-to-Rac signaling module and to test the degree to which it mediates HGF-induced motility and the recovery from ..
  92. DEAN YAW LI; Fiscal Year: 2014
    ..compelling evidence that the inhibition of cytohesins, the guanine nucleotide exchange factors that activate Arf family GTPases, produces anticancer activity in vastly different cell lineages...
  93. WILLIAM BRIAN REEVES; Fiscal Year: 2015
    ..2. Determine the role of T cells in DC and IL-10 mediated protection against ARF. We hypothesize that resident dendritic cell protection in AKI is mediated through their ability to suppress ..
  94. SARA MARIE FRANCIS-REED; Fiscal Year: 2014
    ..My thesis laboratory discovered a new activator of p53 signaling called NIAM (Nuclear Interactor of ARF and Mdm2)...
  95. Bangyan Stiles; Fiscal Year: 2014
    ..we have previously shown to exhibit enhanced [unreadable]-cell regeneration, we plan to test the hypothesis that p16 and cyclin D are responsible for the observed slow regeneration phenotype...
  96. Christin E Burd; Fiscal Year: 2015
    ..Although few molecular indicators of biological age have been indentified, we and others have recently shown that p16INK4a serves a robust and accurate marker of mammalian aging...
  97. Giuseppina Tesco; Fiscal Year: 2015
    ..mechanism of regulation of BACE1 mediated by the BACE1-interacting molecule, GGA3 (Golgi-localized ?-ear-containing ARF binding protein 3)...
  98. HIV-1 Cryptic Epitopes: Implications for Vaccine Design
    Paul A Goepfert; Fiscal Year: 2013
    ..Cryptic epitopes (CE) are translated from alternate reading frames (ARF) and not the main reading frame used to synthesize the functional proteins...
  99. Shi Yong Sun; Fiscal Year: 2016
    ....