p120ctn

Summary

Gene Symbol: p120ctn
Description: catenin delta 1
Alias: CAS, CTNND, P120CAS, P120CTN, p120, p120(CAS), p120(CTN), catenin delta-1, cadherin-associated Src substrate, catenin (cadherin-associated protein), delta 1, p120 catenin
Species: human

Top Publications

  1. pmc The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor
    J M Daniel
    Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232 2175, USA
    Mol Cell Biol 19:3614-23. 1999
  2. ncbi Carotid endarterectomy was performed with lower stroke and death rates than carotid artery stenting in the United States in 2003 and 2004
    James T McPhee
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Vasc Surg 46:1112-1118. 2007
  3. pmc Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells
    Jennifer L Sallee
    Department of Cell and Developmental Biology and Lineberger Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 284:14997-5006. 2009
  4. ncbi Helicobacter pylori alters the distribution of ZO-1 and p120ctn in primary human gastric epithelial cells
    Sabine Krueger
    Department of Pathology, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
    Pathol Res Pract 203:433-44. 2007
  5. ncbi p120 serine and threonine phosphorylation is controlled by multiple ligand-receptor pathways but not cadherin ligation
    Xiaobo Xia
    Department of Cancer Biology, Vanderbilt University Medical Center, 771 Preston Research Building, Nashville, TN 37232, USA
    Exp Cell Res 312:3336-48. 2006
  6. pmc The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin
    J M Daniel
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 15:4819-24. 1995
  7. pmc E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
    J Hülsken
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Cell Biol 127:2061-9. 1994
  8. ncbi The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF
    Richard P Laura
    Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    J Biol Chem 277:12906-14. 2002
  9. ncbi Adhesion-associated and PKC-modulated changes in serine/threonine phosphorylation of p120-catenin
    Xiaobo Xia
    Department of Cancer Biology, Vanderbilt University, PRBII 771, Nashville, Tennessee 37232 6840, USA
    Biochemistry 42:9195-204. 2003
  10. ncbi Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer
    Albert B Reynolds
    Department of Cancer Biology, Vanderbilt University, 440 PRB, 2220 Pierce Ave, Nashville, TN 37232 6840, USA
    Semin Cell Dev Biol 15:657-63. 2004

Research Grants

  1. Carotid angioplasty and stenting in the elderly
    Brahmajee Nallamothu; Fiscal Year: 2009
  2. Salomeh Keyhani; Fiscal Year: 2016
  3. JAMES FRANCIS BURKE; Fiscal Year: 2016
  4. Wei Zhou; Fiscal Year: 2015
  5. Alice J Sheffet; Fiscal Year: 2016
  6. Neuroimaging Correlates of Memory Decline Following Carotid Interventions
    Wei Zhou; Fiscal Year: 2013
  7. Carotid Revascularization Endarterectomy vs Stenting Trial
    Thomas G Brott; Fiscal Year: 2010
  8. GUL NASREEN SHAH; Fiscal Year: 2014
  9. Naphthalene exposure, chromosomal aberrations in poor urban school children.
    Manuela A Orjuela; Fiscal Year: 2012
  10. Seth M Cohen; Fiscal Year: 2016

Detail Information

Publications215 found, 100 shown here

  1. pmc The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor
    J M Daniel
    Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232 2175, USA
    Mol Cell Biol 19:3614-23. 1999
    b>p120(ctn) is an Armadillo repeat domain protein with structural similarity to the cell adhesion cofactors beta-catenin and plakoglobin...
  2. ncbi Carotid endarterectomy was performed with lower stroke and death rates than carotid artery stenting in the United States in 2003 and 2004
    James T McPhee
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Vasc Surg 46:1112-1118. 2007
    ..carotid artery stenosis, the recent United States Food and Drug Administration approval of carotid artery stenting (CAS) may have led to its widespread use outside of clinical trials and registries...
  3. pmc Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells
    Jennifer L Sallee
    Department of Cell and Developmental Biology and Lineberger Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 284:14997-5006. 2009
    ..These data suggest that DEP-1 can modify the phosphorylation state of tight junction proteins and play a role in regulating permeability...
  4. ncbi Helicobacter pylori alters the distribution of ZO-1 and p120ctn in primary human gastric epithelial cells
    Sabine Krueger
    Department of Pathology, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
    Pathol Res Pract 203:433-44. 2007
    ..Cell cultures were characterized and further analyzed by western blot and immunofluorescent staining for ZO-1, p120ctn, and H. pylori CagA...
  5. ncbi p120 serine and threonine phosphorylation is controlled by multiple ligand-receptor pathways but not cadherin ligation
    Xiaobo Xia
    Department of Cancer Biology, Vanderbilt University Medical Center, 771 Preston Research Building, Nashville, TN 37232, USA
    Exp Cell Res 312:3336-48. 2006
    b>p120-catenin (p120) regulates cadherin turnover and is required for cadherin stability...
  6. pmc The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin
    J M Daniel
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Mol Cell Biol 15:4819-24. 1995
    The tyrosine kinase substrate p120cas (CAS), which is structurally similar to the cell adhesion proteins beta-catenin and plakoglobin, was recently shown to associate with the E-cadherin-catenin cell adhesion complex...
  7. pmc E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
    J Hülsken
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Cell Biol 127:2061-9. 1994
    ....
  8. ncbi The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF
    Richard P Laura
    Department of Molecular Oncology, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    J Biol Chem 277:12906-14. 2002
    ..These peptides most closely resembled the C-terminal PDZ domain-binding motifs of three p120-related catenins: delta-catenin, ARVCF, and p0071 (DSWV-COOH)...
  9. ncbi Adhesion-associated and PKC-modulated changes in serine/threonine phosphorylation of p120-catenin
    Xiaobo Xia
    Department of Cancer Biology, Vanderbilt University, PRBII 771, Nashville, Tennessee 37232 6840, USA
    Biochemistry 42:9195-204. 2003
    b>p120-catenin (p120) was originally identified as a tyrosine kinase substrate, and subsequently shown to regulate cadherin-mediated cell-cell adhesion...
  10. ncbi Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer
    Albert B Reynolds
    Department of Cancer Biology, Vanderbilt University, 440 PRB, 2220 Pierce Ave, Nashville, TN 37232 6840, USA
    Semin Cell Dev Biol 15:657-63. 2004
    ..b>p120ctn has been indirectly implicated in clustering for some time, but it now appears that its main function is to ..
  11. ncbi Increased expression of delta-catenin/neural plakophilin-related armadillo protein is associated with the down-regulation and redistribution of E-cadherin and p120ctn in human prostate cancer
    Qun Lu
    Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA
    Hum Pathol 36:1037-48. 2005
    ..delta-catenin immunoreactivity was accompanied by the down-regulation and redistribution of E-cadherin and p120ctn, major cell junction proteins whose inactivation is frequently associated with cancer progression...
  12. pmc Expression of p120-catenin isoforms correlates with genomic and transcriptional phenotype of breast cancer cell lines
    Joana Paredes
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
    Cell Oncol 29:467-76. 2007
    b>P120-catenin is a member of the Armadillo protein family, which is involved in intercellular adhesion and cell signalling...
  13. pmc p120-catenin is a key component of the cadherin-gamma-secretase supercomplex
    Alexi Kiss
    Division of Dermatology, Washington University Medical School, St Louis, MO 63110, USA
    Mol Biol Cell 19:4042-50. 2008
    In this work, we show several previously unknown features of p120-catenin in a cadherin-catenin complex that are critical for our understanding of cadherin-based adhesion and signaling...
  14. doi Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer
    Yang Liu
    Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang 110001, China
    Lung Cancer 63:375-82. 2009
    Studies on a variety of cell lines have shown that p120-catenin can directly regulate the stability of E-cadherin complexes and control the activity of small GTPases to influence cell adhesion...
  15. pmc p120 regulates endothelial permeability independently of its NH2 terminus and Rho binding
    Crystal R Herron
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA
    Am J Physiol Heart Circ Physiol 300:H36-48. 2011
    The association of p120-catenin (p120) with the juxtamembrane domain (JMD) of vascular endothelial (VE)-cadherin is required to maintain VE-cadherin levels and transendothelial resistance (TEER) of endothelial cell monolayers...
  16. doi miR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin
    Shin Hamada
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai City, Miyagi, Japan
    J Cell Physiol 228:1255-63. 2013
    ..cells resulted in the induction of epithelial-mesenchymal transition (EMT) along with the down-regulation of p120 catenin which is a putative target of miR-197...
  17. pmc Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes
    S Shibamoto
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan
    J Cell Biol 128:949-57. 1995
    b>p120 was originally identified as a substrate of pp60src and several receptor tyrosine kinases, but its function is not known...
  18. ncbi The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts
    A B Reynolds
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Exp Cell Res 225:328-37. 1996
    b>p120cas (CAS) is a tyrosine kinase substrate whose phosphorylation has been implicated in cell transformation by Src and in ligand-induced signaling through the EGF, PDGF, and CSF-1 receptors...
  19. ncbi Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells
    M G Lampugnani
    Mario Negri Institute for Pharmacological Research, Milano, Italy
    J Cell Sci 110:2065-77. 1997
    ..Tyrosine phosphorylation of VE-cadherin, beta-catenin and p120, occurred in looser AJ, i.e. in recently confluent cells, and was notably reduced in tightly confluent cultures...
  20. ncbi The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton
    R B Hazan
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 273:9078-84. 1998
    ..of E-cadherin or catenin expression nor the association of catenins (beta-catenin, plakoglobin/gamma-catenin, or p120(cas)) with E-cadherin...
  21. ncbi Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms
    A Keirsebilck
    Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology VIB University of Gent, Belgium
    Genomics 50:129-46. 1998
    ..these junctional plaque proteins are several members of the Armadillo gene family: beta-catenin, plakoglobin, and p120ctn. Recently it became clear that some catenins also mediate nuclear signaling...
  22. ncbi Isolation of human delta-catenin and its binding specificity with presenilin 1
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Neuroreport 10:563-8. 1999
    ..These results suggest that PS1 and PS2 partly differ in function. PS1 loop fragment containing the pathogenic mutation retained the binding ability. We also found another armadillo-protein, p0071, interacted with PS1...
  23. pmc p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells
    S Aono
    Department of Biophysics, Faculty of Science, Kyoto University, Kyoto 606 8502, Japan
    J Cell Biol 145:551-62. 1999
    b>p120(ctn) binds to the cytoplasmic domain of cadherins but its role is poorly understood. Colo 205 cells grow as dispersed cells despite their normal expression of E-cadherin and catenins...
  24. ncbi Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen
    S Aho
    Department of Dermatology, Jefferson Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Cell Biochem 73:390-9. 1999
    ..b>p120ctn is a catenin expressed in different isoforms due to alternative splicing and multiple translation start sites...
  25. pmc Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression
    J van Hengel
    Molecular Cell Biology Unit, Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology VIB, University of Ghent, Ledeganckstraat 35, B 9000 Ghent, Belgium
    Proc Natl Acad Sci U S A 96:7980-5. 1999
    The Armadillo protein p120(ctn) associates with the cytoplasmic domain of cadherins and accumulates at cell-cell junctions...
  26. ncbi p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity
    T Ohkubo
    Department of Biochemistry, Faculty of Medicine, Kagoshima University, Kagoshima 890 8520, Japan
    J Biol Chem 274:21409-15. 1999
    ..In this report, we provide several lines of evidence that p120(ctn) is involved in this negative regulation...
  27. pmc Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion
    M A Thoreson
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175, USA
    J Cell Biol 148:189-202. 2000
    b>p120(ctn) is a catenin whose direct binding to the juxtamembrane domain of classical cadherins suggests a role in regulating cell-cell adhesion...
  28. ncbi Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn)
    G C Zondag
    Division of Cellular Biochemistry, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 275:11264-9. 2000
    ..Here we show that RPTPmu associates with the catenin p120(ctn), a tyrosine kinase substrate and an interacting partner of cadherins...
  29. ncbi E-cadherin-catenin cell-cell adhesion complex and human cancer
    B P Wijnhoven
    Departments of Surgery and Pathology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Br J Surg 87:992-1005. 2000
    ..Recently, much progress has been made in understanding the interaction between the different components of this protein complex and how this cell-cell adhesion complex is modulated in cancer cells...
  30. pmc Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex
    L Baki
    Department of Psychiatry, Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 98:2381-6. 2001
    ..This sequence is also required for E-cadherin binding of protein p120, a known regulator of cadherin-mediated cell adhesion...
  31. ncbi Identification of Src phosphorylation sites in the catenin p120ctn
    D J Mariner
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175, USA
    J Biol Chem 276:28006-13. 2001
    b>p120-catenin (p120(ctn)) interacts with the cytoplasmic tail of cadherins and is thought to regulate cadherin clustering during formation of adherens junctions...
  32. ncbi An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation
    Andres Ferber
    Cardeza Foundation for Hematological Research, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5099, USA
    Exp Cell Res 274:35-44. 2002
    ..Finally, our results for the first time demonstrate that the interaction of VE-cadherin with p120 catenin plays an important role in cellular growth, suggesting that the binding of p120 catenin to cadherins may ..
  33. ncbi Dendrite-like process formation and cytoskeletal remodeling regulated by delta-catenin expression
    Kwonseop Kim
    Department of Anatomy and Cell Biology, The Brody School of Medicine at East Carolina University, Greenville, North Carolina 27858, USA
    Exp Cell Res 275:171-84. 2002
    ..Here we show that the expression of delta-catenin (or NPRAP/Neurojungin), a member of p120(ctn) subfamily of armadillo proteins can induce the branching of dendrite-like processes in 3T3 cells and enhance ..
  34. ncbi Expression analysis of delta-catenin and prostate-specific membrane antigen: their potential as diagnostic markers for prostate cancer
    Michelle Jane Burger
    Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston, Brisbane, Australia
    Int J Cancer 100:228-37. 2002
    ..Thus we have identified delta-catenin (not previously associated with prostatic adenocarcinoma) and confirmed the potential of PSMA as potential candidates for the diagnosis and management of prostate cancer...
  35. pmc A novel role for p120 catenin in E-cadherin function
    Renee C Ireton
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Biol 159:465-76. 2002
    Indirect evidence suggests that p120-catenin (p120) can both positively and negatively affect cadherin adhesiveness...
  36. ncbi Altered expression of the catenin p120 in human cancer: implications for tumor progression
    Molly A Thoreson
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Differentiation 70:583-9. 2002
    ..Here, we focus on p120-catenin and its rising incidence in the pathology literature as a molecule altered in human tumors...
  37. ncbi N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane
    James K Wahl
    University of Nebraska Medical Center, College of Dentistry and Eppley Cancer Center, Omaha, Nebraska 68198 7696, USA
    J Biol Chem 278:17269-76. 2003
    ..In addition, we show that beta-catenin and plakoglobin associate only with phosphorylated proN-cadherin, whereas p120(ctn) can associate with both phosphorylated and non-phosphorylated proN-cadherin...
  38. ncbi Up-regulation, nuclear import, and tumor growth stimulation of the adhesion protein p120 in pancreatic cancer
    Julia Mayerle
    Department of Medicine B, Westfalische Wilhelms Universitat Munster, Germany
    Gastroenterology 124:949-60. 2003
    ..We have studied the role of p120(ctn), a recently discovered member of the cadherin/catenin family, in human pancreatic cancer.
  39. pmc Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho
    Maria Cruz Martinez
    Dept of Neurology, Brigham and Women s Hospital and Harvard Medical School, Harvard Institute of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Cell Biol 162:99-111. 2003
    ..We conclude that delta-catenin contributes to setting a balance between neurite elongation and branching in the elaboration of a complex dendritic tree...
  40. pmc A core function for p120-catenin in cadherin turnover
    Michael A Davis
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6840, USA
    J Cell Biol 163:525-34. 2003
    b>p120-catenin stabilizes epithelial cadherin (E-cadherin) in SW48 cells, but the mechanism has not been established. Here, we show that p120 acts at the cell surface to control cadherin turnover, thereby regulating cadherin levels...
  41. pmc Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells
    Kanyan Xiao
    Department of Dermatology, School of Medicine, Emory University, Atlanta, GA 30322, USA
    J Cell Biol 163:535-45. 2003
    ..The mechanisms by which catenins regulate cadherin function are not fully understood, and the precise function of p120 catenin (p120ctn) has remained particularly elusive...
  42. ncbi p120 catenin associates with microtubules: inverse relationship between microtubule binding and Rho GTPase regulation
    Clemens M Franz
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK
    J Biol Chem 279:6588-94. 2004
    b>p120 catenin (p120ctn), an armadillo protein and component of the cadherin adhesion complex, has been found recently to induce a dendritic morphology by regulating Rho family GTPases...
  43. pmc Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer
    Tatsuhiro Shibata
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Am J Pathol 164:2269-78. 2004
    ..frequently inactivated, and found that E-cadherin down-regulation correlated with the cytoplasmic localization of p120ctn. Similar cytoplasmic localization of p120ctn and growth factor-induced accumulation of tyrosine-phosphorylated ..
  44. ncbi Nuclear import of the BTB/POZ transcriptional regulator Kaiso
    Kevin F Kelly
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada
    J Cell Sci 117:6143-52. 2004
    ..The identification of a Kaiso NLS thus clarifies the mechanism by which Kaiso translocates to the nucleus to regulate transcription of genes with diverse roles in cell growth and development...
  45. pmc p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherin
    Kanyan Xiao
    Department of Dermatology, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 16:5141-51. 2005
    ..VE-cadherin expression levels are regulated by p120 catenin, which prevents lysosomal degradation of cadherins by unknown mechanisms...
  46. pmc p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness
    Masahiro Yanagisawa
    Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    J Cell Biol 174:1087-96. 2006
    ..We show that both p120 catenin and mesenchymal cadherins are required for the invasiveness of E-cadherin-deficient cells...
  47. ncbi p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism
    I R Macpherson
    The Beatson Institute for Cancer Research, Glasgow, UK
    Oncogene 26:5214-28. 2007
    ..b>p120-catenin has emerged as a key player in promoting E-cadherin stability and adherens junction integrity and has been ..
  48. pmc p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin
    Shlomit Boguslavsky
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 104:10882-7. 2007
    The armadillo-family protein, p120 catenin (p120), binds to the juxtamembrane domain of classical cadherins and increases cell-cell junction stability...
  49. pmc The regulatory or phosphorylation domain of p120 catenin controls E-cadherin dynamics at the plasma membrane
    Yuri Fukumoto
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 7696, USA
    Exp Cell Res 314:52-67. 2008
    In contrast to growth factor-stimulated tyrosine phosphorylation of p120, its relatively constitutive serine/threonine phosphorylation is not well understood...
  50. pmc A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease
    Masahiro Yanagisawa
    Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA
    J Biol Chem 283:18344-54. 2008
    b>p120 catenin is a cadherin-associated protein that regulates Rho GTPases and promotes the invasiveness of E-cadherin-deficient cancer cells...
  51. pmc Reduced expression of P120 catenin in cholangiocarcinoma correlated with tumor clinicopathologic parameters
    Bo Zhai
    Department of Ultrasonic Intervention, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
    World J Gastroenterol 14:3739-44. 2008
    To investigate the relationship between the expression of P120 and the clinicopathologic parameters in intrahepatic cholangiocarcinoma (ICC).
  52. pmc p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7
    Seth R Ogden
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2279, USA
    Mol Biol Cell 19:4110-21. 2008
    ..We now report that H. pylori-mediated mmp-7 induction is transcriptionally regulated via aberrant activation of p120-catenin (p120), a component of adherens junctions. H...
  53. pmc PDGF receptor activation induces p120-catenin phosphorylation at serine 879 via a PKCalpha-dependent pathway
    Meredith V Brown
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Exp Cell Res 315:39-49. 2009
    b>p120-catenin (p120) is required for cadherin stability and is thought to have a central role in modulating cell-cell adhesion...
  54. doi P120-catenin isoforms 1A and 3A differently affect invasion and proliferation of lung cancer cells
    Yang Liu
    Department of Pathology, College of Basic Medical Sciences, China Medical University and Department of Pathology, First Affiliated Hospital of China Medical University, Shenyang 110001, China
    Exp Cell Res 315:890-8. 2009
    Different isoforms of p120-catenin (p120ctn), a member of the Armadillo gene family, are variably expressed in different tissues as a result of alternative splicing and the use of multiple translation initiation codons...
  55. doi Ablation of p120-catenin enhances invasion and metastasis of human lung cancer cells
    Yang Liu
    Department of Pathology, College of Basic Medical Sciences, China Medical University, Heping District, Shenyang City, Liaoning Province, China
    Cancer Sci 100:441-8. 2009
    b>p120-catenin, a member of the Armadillo gene family, has emerged as both a master regulator of cadherin stability and an important modulator of small GTPase activities...
  56. pmc Overexpression of E-cadherin on melanoma cells inhibits chemokine-promoted invasion involving p190RhoGAP/p120ctn-dependent inactivation of RhoA
    Isabel Molina-Ortiz
    Department of Cellular and Molecular Physiopathology, Centro de Investigaciones Biologicas, 28040 Madrid, Spain
    J Biol Chem 284:15147-57. 2009
    ..Furthermore, we show that p190RhoGAP and p120ctn associated predominantly on the plasma membrane of cells overexpressing E-cadherin, and that E-cadherin-bound ..
  57. doi Kaiso is expressed in lung cancer: its expression and localization is affected by p120ctn
    Shun Dong Dai
    Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang 110001, China
    Lung Cancer 67:205-15. 2010
    Kaiso is a recently identified transcription factor that binds to p120-catenin (p120ctn), an Armadillo catenin and cell adhesion cofactor...
  58. doi An acidic extracellular pH disrupts adherens junctions in HepG2 cells by Src kinases-dependent modification of E-cadherin
    Ying Chen
    Department of Anatomy, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
    J Cell Biochem 108:851-9. 2009
    ..pH 6.6 treatment activated c-Src and Fyn kinase and induced tyrosine phosphorylation of p120 catenin (p120ctn) and E-cadherin. Inhibition of Src family kinases by PP2 attenuated the pH 6...
  59. doi p120ctn isoform 1 expression significantly correlates with abnormal expression of E-cadherin and poor survival of lung cancer patients
    Yuan Miao
    Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, 110001, Shenyang, China
    Med Oncol 27:880-6. 2010
    ..While the mean survival times of patients with normal p120 ctn isoform 1 or pan-p120ctn expression differed significantly, the mean survival times of patients with abnormal ..
  60. doi Cadherin switching and activation of p120 catenin signaling are mediators of gonadotropin-releasing hormone to promote tumor cell migration and invasion in ovarian cancer
    L W T Cheung
    School of Biological Sciences, University of Hong Kong, Hong Kong, PR China
    Oncogene 29:2427-40. 2010
    ..effects of P-cadherin were mediated by activation of the Rho GTPases, Rac1, and Cdc42, through accumulation of p120 catenin (p120(ctn)) in the cytoplasm...
  61. doi Altered expression of p120catenin predicts poor outcome in invasive breast cancer
    K Talvinen
    Department of Pathology, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland
    J Cancer Res Clin Oncol 136:1377-87. 2010
    ..In this study, we investigate the role of altered immunoexpression of p120catenin isoforms in the prognosis of invasive breast cancer (n = 351)...
  62. doi Involvement of p120 in LPS-induced NF-kappaB activation and IL-8 production in human bronchial epithelial cells
    Manxiang Wang
    Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Pulmonary Disease, Ministry of Health of China, No 13 Hangkong Road, Wuhan, Hubei, PR China
    Toxicol Lett 195:75-81. 2010
    b>P120-catenin (p120), a prototypic member of a subfamily of Armadillo repeat domain (Arm domain) proteins, not only participates in cell-cell adhesion, but also mediates inflammatory responses in the skin...
  63. doi Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion
    Noboru Ishiyama
    Division of Signaling Biology, Ontario Cancer Institute, ON, Canada
    Cell 141:117-28. 2010
    The association of p120 catenin (p120) with the juxtamembrane domain (JMD) of the cadherin cytoplasmic tail is critical for the surface stability of cadherin-catenin cell-cell adhesion complexes...
  64. doi p120-catenin is transcriptionally downregulated by FOXC2 in non-small cell lung cancer cells
    Fariborz Mortazavi
    Division of Hematology Oncology, Veterans Administration, Greater Los Angeles, West Los Angeles, California, USA
    Mol Cancer Res 8:762-74. 2010
    p120-catenin (p120ctn) plays a major role in cell adhesion and motility through the regulation of E-cadherin and interaction with RhoGTPase and Rac1...
  65. pmc Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members
    Ji Yeon Hong
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Cell Sci 123:4351-65. 2010
    ..embryos and mammalian cell lines, we report that the degradation machinery of the canonical Wnt pathway modulates p120-catenin protein stability through mechanisms shared with those regulating β-catenin...
  66. doi p120-catenin isoform 3 regulates subcellular localization of Kaiso and promotes invasion in lung cancer cells via a phosphorylation-dependent mechanism
    Peng Xin Zhang
    Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang 110001, PR China
    Int J Oncol 38:1625-35. 2011
    b>p120-catenin regulates E-cadherin stability at the plasma membrane as well as Rho GTPase activity in the cytoplasm, and also interacts with the transcriptional repressor, Kaiso, in the nucleus...
  67. pmc Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene
    Douglas B Stairs
    Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cancer Cell 19:470-83. 2011
    p120-catenin (p120ctn) interacts with E-cadherin, but to our knowledge, no formal proof that p120ctn functions as a bona fide tumor suppressor gene has emerged to date...
  68. pmc Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance
    Ron C J Schackmann
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Invest 121:3176-88. 2011
    ..Using a mouse model of human ILC, we show here that cytosolic p120-catenin (p120) regulates tumor growth upon loss of E-cadherin through the induction of anoikis resistance...
  69. pmc Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin
    Andrew L Smith
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
    Mol Biol Cell 23:99-110. 2012
    ..b>p120-catenin (p120) regulates both cadherin stability and actin dynamics, but the relationship between these two ..
  70. pmc P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively
    Guiyang Jiang
    Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China
    PLoS ONE 7:e30303. 2012
    The different mechanisms involved in p120-catenin (p120ctn) isoforms' 1/3 regulation of cell cycle progression are still not elucidated to date.
  71. pmc Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion
    Yuliya I Petrova
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Biol Cell 23:2092-108. 2012
    ..Activation also induces p120-catenin dephosphorylation, as well as changes in the cadherin cytoplasmic domain...
  72. doi Regulation of adherens junctions by Rho GTPases and p120-catenin
    Andre Menke
    Molecular Oncology of Solid Tumors, Internal Medicine V, Justus Liebig University Giessen, Schubertstr 81, BFS Building, 35392 Giessen, Germany
    Arch Biochem Biophys 524:48-55. 2012
    ..will summarize the current findings about the influence of Rho GTPases on the formation and maintenance of adherens junction and will then proceed to discuss the involvement of p120-catenin on cell-cell adhesion and tumor cell migration.
  73. pmc N-terminal 1-54 amino acid sequence and Armadillo repeat domain are indispensable for P120-catenin isoform 1A in regulating E-cadherin
    Juanhan Yu
    Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China
    PLoS ONE 7:e37008. 2012
    P120-catenin (p120ctn) exerts important roles in regulating E-cadherin and invasiveness in cancer cells. However, the mechanisms by which p120ctn isoforms 1 and 3 modulate E-cadherin expression are poorly understood...
  74. pmc p120-catenin binding masks an endocytic signal conserved in classical cadherins
    Benjamin A Nanes
    Graduate Program in Biochemistry, Cell, and Developmental Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Biol 199:365-80. 2012
    b>p120-catenin (p120) binds to the cytoplasmic tails of classical cadherins and inhibits cadherin endocytosis...
  75. ncbi The catenin p120ctn inhibits Kaiso-mediated transcriptional repression of the beta-catenin/TCF target gene matrilysin
    Christopher M Spring
    Department of Biology, LSB 331, McMaster University, 1280 Main Street West, Hamilton, ON, Canada L8S 4K1
    Exp Cell Res 305:253-65. 2005
    ..Kaiso was first identified as a specific binding partner for the Armadillo catenin and cell adhesion cofactor, p120ctn. Kaiso is a unique POZ protein with bi-modal DNA-binding properties; it associates with a sequence-specific DNA ..
  76. pmc N-cadherin levels in endothelial cells are regulated by monolayer maturity and p120 availability
    Deana M Ferreri
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    Cell Commun Adhes 15:333-49. 2008
    ..Experiments in which p120, a catenin that binds N- and VE-cadherin, was knocked down or overexpressed indicate that these two cadherins ..
  77. pmc P120 catenin represses transcriptional activity through Kaiso in endothelial cells
    Jihang Zhang
    Center for Cardiovascular Sciences, Albany Medical Center, Albany, NY, USA
    Microvasc Res 80:233-9. 2010
    b>P120 catenin (p120ctn) belongs to the family of Armadillo repeat-containing proteins, which are believed to have dual functions of cell-cell adhesion and transcriptional regulation...
  78. pmc Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia
    M S Kinch
    Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill 27599, USA
    J Cell Biol 130:461-71. 1995
    ..Whereas in the normal cells beta-catenin is found in association with E-cadherin, p120 Cas is not...
  79. pmc Cardiovascular actions of the furoxan CAS 1609, a novel nitric oxide donor
    H Bohn
    Department of Pharmacology, Cassella AG, Frankfurt Main, Germany
    Br J Pharmacol 114:1605-12. 1995
    1. This study examines the cardiovascular effects of CAS 1609 (4-hydroxymethyl-furoxan-3-carboxamide) in vitro as well as in vivo in various animal models. 2...
  80. ncbi In vitro activity against clinically important gram-positive and gram-negative bacteria of sulbactam, alone and in combination with ampicillin, cefotaxime, mezlocillin, and piperacillin
    A F Schmalreck
    Department Microbiology, Pftzer Mack, Illertissen Fed Rep of Germany
    Arzneimittelforschung 40:1145-55. 1990
    ..of the single agents, and the synergistic/antagonistic action of three different combinations of ampicillin (AMP, CAS 69-53-4), cefotaxime (CTX, CAS 63527-52-6), mezlocillin (MEZ, CAS 51481-65-3), and piperacillin (PIP, CAS 61477-96-..
  81. ncbi [Origin and role of circulating catecholamines in the normotensive sympathectomized rat]
    M Lo
    , URA CNRS 606, , Lyon
    Arch Mal Coeur Vaiss 84:1231-4. 1991
    ..Am J Physiol 1990; 259: H1337). Therefore, the origin and role of circulating catecholamines (CAs) in BP maintenance were examined in conscious normotensive control, sympathectomized (SNX)--daily s.c...
  82. ncbi Intraluminal casein model of necrotizing enterocolitis for assessment of mucosal destruction, bacterial translocation, and the effects of allopurinol and N-acetylcysteine
    A Koivusalo
    Children s Hospital, Helsinki University, Helsinki, Finland
    Pediatr Surg Int 18:712-7. 2002
    ..NEC was induced in 21 by injecting casein-d-gluconate into a loop of terminal ileum: group Cas (n = 7) had no premedication, in group Cas/AL (n = 7) intravenous (i.v...
  83. ncbi Serum Th1 and Th2 profile cytokine level changes in patients with Graves' ophthalmopathy treated with corticosteroids
    J Mysliwiec
    Department of Endocrinology, Medical School of Białystok, M C Skłodowskiej Curie 24 a, 15 267 Białystok, Poland
    Horm Metab Res 33:739-43. 2001
    ..with Graves' disease without ophthalmopathy (Gd), 16 patients with clinical symptoms of ophthalmopathy (GO) (CAS over 3 points, last consultation record for GO less than a year old) and 16 healthy volunteers...
  84. ncbi Tyrosine dephosphorylation, but not phosphorylation, of p130Cas is dependent on integrin alpha IIb beta 3-mediated aggregation in platelets: implication of p130Cas involvement in pathways unrelated to cytoskeletal reorganization
    T Ohmori
    Department of Laboratory Medicine, Yamanashi Medical University, Nakakoma, Yamanashi 409 3898, Japan
    Biochemistry 39:5797-807. 2000
    The newly described adapter molecule p130 Crk-associated substrate (Cas) has been reported to contribute to cytoskeletal organization through assembly of actin filaments and to be pivotal in embryonic development and in oncogene-mediated ..
  85. doi Effects of ring castration with local anesthesia and analgesia in Holstein calves at 3 months of age on welfare indicators
    S Marti
    Department of Ruminant Production, Institut de Recerca i Tecnologia Agroalimentaries IRTA, and Animal Nutrition, Management, and Welfare Research Group, Torre Marimon, 08140 Caldes de Montbui, Barcelona, Spain
    J Anim Sci 88:2789-96. 2010
    ..43 kg of BW and 95 +/- 1.5 d of age) were randomly assigned to 2 treatments [intact (INT), n = 23; or castrated (CAS), n = 24] to evaluate the effect of ring castration at 3 mo of age on welfare indicators...
  86. ncbi In vitro anti-HIV potency of stampidine alone and in combination with standard anti-HIV drugs
    Fatih M Uckun
    Drug Discovery Program, Department of Virology, Parker Hughes Institute, St Paul, MN 55113, USA
    Arzneimittelforschung 55:223-31. 2005
    The purpose of the present study was compare the in vitro anti-HIV potency stampidine (CAS 217178-62-6), a novel aryl phosphate derivative of stavudine (CAS 3056-17-5), and drug combinations containing stampidine to the anti-HIV tency of ..
  87. ncbi Role of ascorbic acid on mercuric chloride-induced genotoxicity in human blood cultures
    M V Rao
    Cytogenetics Laboratory, Department of Zoology, University School of Sciences, Gujarat University, 380009, Ahmedabad, India
    Toxicol In Vitro 15:649-54. 2001
    ..We assessed the proliferative rate index (PRI), sister chromatid exchange (SCE) and chromosomal aberrations (CAS) in control and MC-treated cultures with and without vitamin C supplementation...
  88. ncbi Carotid angioplasty and stent-induced bradycardia and hypotension: Impact of prophylactic atropine administration and prior carotid endarterectomy
    Neal S Cayne
    Department of Vascular Surgery, New York University Medical Center, NY 10016, USA
    J Vasc Surg 41:956-61. 2005
    ..with routine prophylactic administration, before balloon inflation, during carotid angioplasty and stenting (CAS)...
  89. doi Risk-adjusted 30-day outcomes of carotid stenting and endarterectomy: results from the SVS Vascular Registry
    Anton N Sidawy
    Department of Surgery, Washington VA Medical Center, Washington, DC, USA
    J Vasc Surg 49:71-9. 2009
    ..to the Centers for Medicare and Medicaid Services' (CMS) National Coverage Decision on carotid artery stenting (CAS)...
  90. ncbi Complete sphenoethmoidectomy and computer-assisted surgery
    A R Gunkel
    ENT-Department, University of Innsbruck, Austria
    Acta Otorhinolaryngol Belg 49:257-61. 1995
    ..The ISG-system uses a mechanical arm to localize the probe in the patient. Using Computer-Assisted-Surgery (CAS) does not significantly extend the time needed for surgery...
  91. ncbi Contribution of late professor T. C. Tung to the experimental embryology of Amphioxus. In memory of the 20th anniversary of Professor T. C. Tung's death
    S Yan
    Institute of Developmental Biology, The Chinese Academy of Sciences, Beijing, People s Republic of China
    Dev Growth Differ 41:503-22. 1999
    ..of Shandong University (1952-1960), Director of the Marine Biological Institute, the Chinese Academy of Sciences (CAS) in Qingdao (1949-1958), Director of the Institute of Oceanology (CAS) in Qingdao (1959-1966), Director of the ..
  92. ncbi [Scaphoid percutaneous osteosynthesis by screw using computer assisted surgery: an experimental study]
    P Liverneaux
    Service de Chirurgie Orthopedique, centre hospitalier BP9, 17301 Rochefort sur mer, France
    Chir Main 24:169-73. 2005
    ..In this context, computer assisted surgery (CAS) may be useful and deserves further study...
  93. ncbi Occurrence and reductions of pharmaceuticals and personal care products and estrogens by municipal wastewater treatment plants in Ontario, Canada
    Lori Lishman
    Environment Canada, National Water Research Institute, 867 Lakeshore Road, P O Box 5050, Burlington, Ontario, Canada L7R 4A6
    Sci Total Environ 367:544-58. 2006
    ..The impact of treatment configuration (e.g. lagoons, conventional activated sludge (CAS), and CAS followed by media filtration (CAS+filtration)) was also examined...
  94. ncbi Bifidobacterium lactis Bb-12 and Lactobacillus salivarius UCC500 modify carboxylic acid formation in the hindgut of rats given pectin, inulin, and lactitol
    Ulf Nilsson
    Department of Microbiology, University College, Cork, Ireland
    J Nutr 136:2175-80. 2006
    ..of Bifidobacterium lactis (Bb-12) and Lactobacillus salivarius (UCC500) on the formation of carboxylic acids (CAs) was studied in the hindgut of rats fed pectin, inulin of low solubility, and lactitol...
  95. ncbi Clinical, double-blind, placebo-controlled study investigating the combination of acetylsalicylic acid and pseudoephedrine for the symptomatic treatment of nasal congestion associated with common cold
    Irene Loose
    Bayer HealthCare AG, Consumer Care EU, R and D Medical Affairs, Leverkusen, Germany
    Arzneimittelforschung 54:513-21. 2004
    It was the aim of this clinical study to demonstrate the efficacy of 1000 mg acetylsalicylic acid (ASA, CAS 50-78-2) in combination with 60 mg pseudoephedrine (PSE, CAS 90-82-4), compared with placebo, in the symptomatic treatment of ..
  96. ncbi Correlation of daily urinary excretion of met-enkephalin-like immunoreactivity and epinephrine in men
    T Yanase
    Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Horm Metab Res 19:653-5. 1987
    ..source of urinary Met-enkephalin-like immunoreactivity (MELI), 24-h urinary excretion of MELI and catecholamines (CAs) were examined in normal subjects and patients with tuberculous Addison's disease...
  97. ncbi Sleep EEG of patients with obsessive-compulsive disorder
    F Hohagen
    Psychiatric Department, University of Freiburg, Germany
    Eur Arch Psychiatry Clin Neurosci 243:273-8. 1994
    ..sleep variables and rating inventories for obsession and compulsions (Y-BOCS), depression (Hamilton) and anxiety (CAS). A secondary depression did not influence sleep EEG variables...
  98. ncbi Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors
    Stacey C Chapman
    Department of Neurobiology and Physiology, Northwestern University, OT Hogan 4 150, 2153 N Campus Dr, Evanston, IL, USA
    Mol Cell Endocrinol 196:79-93. 2002
    ..Two candidate inhibin co-receptors, betaglycan and InhBP/p120, interact with activin receptors and augment inhibin antagonism of activin action...
  99. ncbi Effect of endogenous catecholamines on apoptosis of Con A-activated lymphocytes of rats
    Jian Lan Jiang
    Department of Biological Science and Technology, School of Life Sciences, Mailbox 426, Nanjing University, Nanjing 210093, China
    J Neuroimmunol 192:79-88. 2007
    Our previous studies show that lymphocytes express tyrosine hydroxylase (TH) and synthesize catecholamines (CAs) including dopamine, epinephrine and norepinephrine, and that the lymphocytes-derived endogenous CAs affect function of ..
  100. ncbi Screening for carotid artery stenosis: an update of the evidence for the U.S. Preventive Services Task Force
    Tracy Wolff
    Center for Primary Care, Prevention, and Clinical Partnerships, Agency for Healthcare Research and Quality, Rockville, Maryland 20850, USA
    Ann Intern Med 147:860-70. 2007
    ..The proportion of all strokes attributable to previously asymptomatic carotid artery stenosis (CAS) is low. In 1996, the U.S...
  101. ncbi Natural history of carotid artery stenosis contralateral to endarterectomy: results from two randomized prospective trials
    Ali F Aburahma
    Department of Surgery, Robert C Byrd Health Sciences Center at West Virginia University, Charleston Area Medical Center, 3100 MacCorkle Avenue SE, Ste 603, Charleston, WV 25304, USA
    J Vasc Surg 38:1154-61. 2003
    A few nonrandomized studies have reported the natural history of carotid artery stenosis (CAS) contralateral to carotid endarterectomy (CEA). This study analyzed this condition with data from two randomized prospective trials.

Research Grants79

  1. Carotid angioplasty and stenting in the elderly
    Brahmajee Nallamothu; Fiscal Year: 2009
    ..A promising and innovative alternative to CEA is carotid angioplasty and stenting (CAS), a minimally-invasive, endovascular procedure that may be of particular benefit in high-risk patients...
  2. Salomeh Keyhani; Fiscal Year: 2016
    ..In parallel, as the surgical complication rate for CEA has decreased, the use of carotid artery stenting (CAS) has been gaining favor in the treatment of asymptomatic carotid stenosis...
  3. JAMES FRANCIS BURKE; Fiscal Year: 2016
    ..to estimate the expected net benefit of carotid endarterectomy (CEA) vs. carotid artery stenting (CAS) for individual patients in the CREST trial using refined multivariable outcome prediction methods. 2...
  4. Wei Zhou; Fiscal Year: 2015
    ..Carotid endarterectomy (CEA) and stenting (CAS) have shown to be effective in stroke prevention...
  5. Alice J Sheffet; Fiscal Year: 2016
    ..that is designed to establish the relative efficacy of carotid endarterectomy (CEA) versus carotid artery stenting (CAS)...
  6. Neuroimaging Correlates of Memory Decline Following Carotid Interventions
    Wei Zhou; Fiscal Year: 2013
    ..Whereas both carotid endarterectomy (CEA) and carotid stenting (CAS) are effective treatments for stroke prevention in patients with severe carotid occlusive diseases, recent studies ..
  7. Carotid Revascularization Endarterectomy vs Stenting Trial
    Thomas G Brott; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Carotid artery stenting (CAS) is an emerging procedure that has been used increasingly in recent years...
  8. GUL NASREEN SHAH; Fiscal Year: 2014
    ..Mitochondrial carbonic anhydrases (CAs) are important in the generation of reactive oxygen species (ROS) and the subsequent oxidative stress that arises ..
  9. Naphthalene exposure, chromosomal aberrations in poor urban school children.
    Manuela A Orjuela; Fiscal Year: 2012
    ..children in NYC, prenatal maternal exposure to airborne PAH is associated with infant chromosomal aberrations (CAs) measured in cord blood using Whole Chromosome Paints Fluorescent In Situ Hybridization (WCPFISH)...
  10. Seth M Cohen; Fiscal Year: 2016
    ..on two specific Zn2+dependent systems (Aim 2, Aim 3), the matrix metalloproteinases (MMPs) and carbonic anhydrases (CAs)...
  11. Updating Chromosome Aberration Simulator (CAS) Software
    Rainer Sachs; Fiscal Year: 2006
    ..The pioneering software, developed by a Berkeley/Harvard team, is CAS (chromosome aberration simulator), a package implementing basic biophysical models of aberration formation via ..
  12. p120-catenin sub-family functions
    Pierre D McCrea; Fiscal Year: 2010
    ..we focus upon the roles of less understood members of the catenin family of proteins, specifically members of the p120-catenin sub-family (p120- catenin;ARVCF-catenin;delta-catenin)...
  13. GENDER DIFFERENCES IN STIMULANT ACTION
    Cynthia M Kuhn; Fiscal Year: 2012
    ..ability of estrogen receptor agonists to maintain these parameters in ovariectomized (OVX) females and castrated (CAS) males, and of androgen to do the same in CAS males will be determined...
  14. TOPOGENESIS OF NA/K-ATPASE IN POLARIZED EPITHELIAL CELLS
    W James Nelson; Fiscal Year: 2012
    ..We will build upon these results in proposed studies. We will define roles of alpha-catenin and p120 in regulating cell-cell adhesion and membrane dynamics...
  15. Thomas J Meade; Fiscal Year: 2015
    ..AIM 1. To synthesize and test a series of CAs that targets the estrogen receptor...
  16. n-Stent Stenosis Model in Type 2 Diabetic Rats
    Tiangen Wu; Fiscal Year: 2005
    ..artery disease involves percutanesous transluminal coronary angioplasty (PTCA) and coronary artery stenting (CAS)...
  17. Ailong Ke; Fiscal Year: 2015
    ..CRISPR-Cas defense systems have been identified in 88% of archaeal genomes and 39% of bacterial genomes thus far sequenced, ..
  18. Nicholas P Cianciotto; Fiscal Year: 2014
    ..Upstream of the CRISPR array are the CRISPR-associated sequences (cas) genes. CRISPRCas loci have been primarily implicated in immunity to phage and plasmid...
  19. Albert B Reynolds; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): p120-catenin (p120) was originally identified as a tyrosine phosphorylated substrate of oncogenic Src and of several prominent Growth Factor (GF)-activated Receptor Tyrosine Kinases (RTKs)(e.g...
  20. Manabu Kurokawa; Fiscal Year: 2014
    ..that apoptosome inhibition can occur by two key independent pathways: HSP90[unreadable] hypophosphorylation and CAS downregulation...
  21. GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATION
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2010
    ..tyrosine kinase p125 focal adhesion kinase (FAK) and the adaptor proteins p130 Crk-associated substrate (CAS) and paxillin, which are implicated in cell migration and proliferation...
  22. The Role of HEF1 in Ovarian Cancer Development, Progression, and Metastasis
    Denise C Connolly; Fiscal Year: 2013
    HEF1/NEDD9/Cas-L (HEF1) is a molecular scaffolding protein that mediates cellular signaling from focal adhesions during interphase and at centrosomes during mitosis...
  23. c-Src/EGF Receptors Interactions and Therapeutic Resistance in Breast Cancer
    Sarah J Parsons; Fiscal Year: 2010
    ..The adaptor protein, p130Cas (Cas), may play a role in this process by activating c-Src and promoting phosphorylation of Y845 independently of ligand...
  24. TARGETS OF AMINO ACID RESTRICTION IN PROSTATE CANCER
    Gary G Meadows; Fiscal Year: 2009
    ..The specific aims are: 1) Identify if FAK/Cas/Crk or Rho/Ras pathway is the molecular target(s) of specific amino acid restriction in integrin-mediated ..
  25. STEROID CONTROL OF EPITHELIAL CELL-CELL INTERACTIONS
    Gary L Firestone; Fiscal Year: 2011
    ..mediated degradation of GSK3 (Glycogen Synthase Kinase-3), a multifunctional serine/threonine kinase, and of CAS (Cellular Apoptosis Susceptibility gene), a component of the nuclear transport machinery that binds to importin-..
  26. Mechanisms of Breast Tumor Cell Growth, Motility, and Antiestrogen Response
    Amy H Bouton; Fiscal Year: 2013
    ..on a triad of signaling molecules that includes the protein tyrosine kinase c-Src, the adapter molecule p130Cas (Cas), and a cytoplasmic molecule called breast cancer antiestrogen resistance-3 (BCAR3)...
  27. Sergey M Troyanovsky; Fiscal Year: 2014
    ..The proteins are interconnected via p120- catenin, a critical regulator of cadherin-based adhesion...
  28. Dwight A Towler; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Calcific aortic stenosis (CAS) arises from arteriosclerotic processes and valve morphological variants that progressively impair valve function, ultimately increasing the risk for congestive heart ..
  29. Engineering of Human Corneal Endothelial Grafts
    Ying Ting Zhu; Fiscal Year: 2012
    ..proposes to develop a novel strategy of engineering human corneal endothelium based on selective activation of p120ctn/Kaiso signaling using interference RNA technology targeted at p120-catenin...
  30. Jonathan R Terman; Fiscal Year: 2016
    ..this question has come with our recent identification that MICAL interacts with the SH3-domain containing protein Cas in neurons...
  31. Preclinical Efficacy And Safety Evaluation Of Graphene Nanoparticle-based Magneti
    Balaji Sitharaman; Fiscal Year: 2013
    ..Exogenous chemicals called contrast agents (CAs) synthesized using the elements iodine and gadolinium has been widely employed to improve the diagnostic confidence ..
  32. Collaborative Care for Depressed Elders in China
    Shulin Chen; Fiscal Year: 2013
    ..HDRS, MMSE, CAS, SF-12, Treatment Stigma and the Client Satisfaction Questionnaire will be used to assess patients'outcomes;..
  33. Mechanisms of CRISPR Interference
    Erik J Sontheimer; Fiscal Year: 2013
    ..CRISPR loci are accompanied by a set of cas (CRISPR-associated) genes that encode protein components of the underlying enzymatic machinery...
  34. Role of p120-catenin in oral squamous cell carcinoma
    Zhongjian Xie; Fiscal Year: 2010
    b>P120-catenin is a cytoplasmic protein directly associated with the cell-cell adhesion molecule Ecadherin in the plasma membrane...
  35. The Role of p120 Catenin in Metanephric Kidney Development
    DENISE K MARCIANO; Fiscal Year: 2012
    ..My research proposal, entitled "The role of p120 catenin in metanephric kidney development", is constructed to provide a framework to achieve my goals...
  36. The Role of Afadin in Coordinating Cell Adhesion Molecules during Synaptogenesis
    GERARD MJ BEAUDOIN; Fiscal Year: 2010
    ..As previous analysis has not satisfactorily demonstrated how afadin associates with alpha-catenin and p120-catenin, additional analysis will be directed at examining the domains of afadin that binds these catenins...
  37. Adhip P N Majumdar; Fiscal Year: 2014
    ..higher incidence and mortality rates for colorectal cancer (CRC) than European Americans/Caucasians (CAs)...
  38. HuR Regulation of HSP 70 in Brain Reperfusion
    JEFFREY SZYMANSKI; Fiscal Year: 2013
    ..of HuR and whether the location of hsp70 mRNA differs between ischemia-resistant CA1 and ischemia-vulnerable CAS neurons. 2. To determine if HuR nuclear export is causally linked to HSP70 translation...
  39. Role of neuroligins in long-term plasticity at excitatory and inhibitory synapses
    Holly Sue Engelman; Fiscal Year: 2010
    ..Whole cell recordings will be made from CAS neurons while stimulating the mossy fiber pathway to induce NMDA R LTP...
  40. William A Catterall; Fiscal Year: 2016
    ..1 channels and CaS proteins based on Rosetta structural modeling, chemical crosslinking, and high-resolution mass spectrometry...
  41. Guochang Hu; Fiscal Year: 2016
    ..When this production becomes uncontrolled and excessive, it leads to the development of septic shock. p120-catenin, a component of adherens junctions in endothelial cells and other polarized adherent cells, has recently ..
  42. Regulation of p120-catenin tumor supressor activities
    DOUGLAS STAIRS; Fiscal Year: 2010
    ..My research will focus on p120- catenin (p120ctn) and its ability to modulate tumorigenesis as well as cell migration and invasion in vitro and in vivo...
  43. Barry M Gumbiner; Fiscal Year: 2016
    ..This included the discovery of E-cadherin activating monoclonal antibodies (mAbs) and a role for p120-catenin phosphorylation and microtubules in the control of E-cadherin activity state...
  44. KONSTANTIN V SEVERINOV; Fiscal Year: 2016
    ..against foreign DNA is based on CRISPR (clustered regularly interspaced short palindromic repeats) cassettes and cas genes. A CRISPR cassette consists of direct repeats interspersed with spacers of highly variable sequence...
  45. Integrative mouse pathobiology: GI epithelial biology and genetics
    Hiroshi Nakagawa; Fiscal Year: 2011
    ..carcinogenesis in new mouse models;(2) To determine the roles of Notch for tumor progression in a conditional p120-catenin knockout mouse model;and (3) To delineate the roles of Notch in mouse CSCs in a novel orthotopic ..
  46. Prognostic value of AR mutation in primary African American prostate cancer
    Shahriar Koochekpour; Fiscal Year: 2011
    ..cancer (PCa) incidence and mortality rate is higher in African-American (AA) men than in Caucasian Americans (CAs). AA men with PCa also present with higher tumor volume, more advanced tumor stage, and higher Gleason grade...
  47. Andrew P Kowalczyk; Fiscal Year: 2015
    ..b>p120 catenin regulation of VE-cadherin is the focus of this proposal...
  48. KEITH W NEHRKE; Fiscal Year: 2014
    ..This application is focused on understanding the mechanism behind nuclear CAs protective effects in nematodes and translating these findings to mammals as a way of targeting cognitive ..
  49. Using CRISPR immunity to prevent the spread of virulence traits among pathogens
    Luciano A Marraffini; Fiscal Year: 2012
    ..CRISPR loci, and their associated cas (CRISPR associated) genes, encode a sequence-specific defense mechanism against bacteriophages and plasmids, the ..
  50. Regulation and Function of PTP-PEST in colon carcinoma
    SARITA KANDULA SASTRY; Fiscal Year: 2012
    ..b>p120 catenin is a tyrosine phosphorylated cadherin binding protein that regulates Rho GTPase activity...
  51. Regulation of p120-catenin tumor supressor activities
    DOUGLAS STAIRS; Fiscal Year: 2013
    ..My research will focus on p120- catenin (p120ctn) and its ability to modulate tumorigenesis as well as cell migration and invasion in vitro and in vivo...
  52. REBECCA TERNS; Fiscal Year: 2015
    ..discovered that prokaryotes (archaea and bacteria) have small RNA-based adaptive immune systems, called CRISPR-Cas systems that effectively control invasions of viruses and plasmids...
  53. LEI STANLEY QI; Fiscal Year: 2016
    ..The method requires only a single modified Cas protein (catalytically inactive) and a designed small guide RNA with a 20-basepair complementary region to any gene ..
  54. Preliminary Clinical Trial of New Therapy for Patients with Severe Tinnitus
    RUTH QUILLIAN WOLEVER; Fiscal Year: 2012
    ..tinnitus are unable to habituate to the tinnitus sound that most likely originates in the central auditory system (CAS) in response to peripheral injury...
  55. RASA1-mediated control of lymphatic vessel growth and function
    Philip D King; Fiscal Year: 2012
    ..In this regard, we have recently shown that the p120 Ras GTPase-activating protein (p120 RasGAP, also known as RASA1), a prototypical negative-regulator of the Ras ..
  56. Hiroshi Nakagawa; Fiscal Year: 2015
    ..carcinogenesis in new mouse models;(2) To determine the roles of Notch for tumor progression in a conditional p120-catenin knockout mouse model;and (3) To delineate the roles of Notch in mouse CSCs in a novel orthotopic ..
  57. John D Bartlett; Fiscal Year: 2014
    ..b>p120-catenin (p120) stabilizes cadherins to the cell surface and absence of p120 significantly reduces the presence cell ..
  58. Asrar B Malik; Fiscal Year: 2016
    ..vascular permeability and edema formation;(ii) to determine the role of p190RhoGAP interaction with the AJ protein p120-catenin in the mechanism of inactivation of RhoA signaling and in promoting Cdc42-mediated AJs re-assembly and ..
  59. Mechanisms of Nucleocytoplasmic Transport
    Siegfried M Musser; Fiscal Year: 2012
    ..The Specific Aims of the project are: (1) to characterize Imp ?/CAS complex assembly during nuclear import and disassembly during nuclear export;(2) to determine the effect of ..
  60. Cognitive Recovery and Neuronal Plasticity after Stroke in the Aged
    REBECCA LYNN GILLANI; Fiscal Year: 2010
    ..Neurons in the hippocampus (CA1 pyramidal cells, CAS pyramidal cells, and DG granule cells) and entorhinal cortex (layer II stellate cells, layer III pyramidal cells, ..
  61. Parenting after a Prenatal Diagnosis: Expecting the Unexpected
    Anne Chevalier McKechnie; Fiscal Year: 2013
    ..medical and surgical interventions are improving the physical outcomes for infants diagnosed with a range of severe CAs, many of these children still struggle with neurodevelopmental and psychological complications...
  62. INTEGRIN SIGNALING DURING BREAST TUMORIGENESIS
    Filippo G Giancotti; Fiscal Year: 2013
    ..Silencing will be used to confirm that CAS mediates the pro-tumorigenic effect of FAK...
  63. Sharon Rosenzweig-Lipson; Fiscal Year: 2016
    ..Preclinical studies in an animal model of this condition, in which hippocampal CAS neurons are hyperactive in aged rats with memory loss, demonstrates that selective GABAA ?5 receptor agonists are ..
  64. Sangeeta Ray; Fiscal Year: 2015
    ..Dr. Ray will develop PSMA-targeted multimodal contrast agents (CAs) followed by evaluation of these compounds through in vitro studies and in vivo MR imaging in relevant animal ..
  65. Enamelysin Processing Mechanisms in Amelogenesis
    John D Bartlett; Fiscal Year: 2011
    ..b>p120-catenin (p120) stabilizes cadherins to the cell surface and absence of p120 significantly reduces the presence cell ..
  66. Lawrence B Holzman; Fiscal Year: 2016
    ..Phosphorylation of FAK and Cas are induced in podocytes of patients with human minimal change disease and in membranous nephropathy relative to ..
  67. Richard M Peek; Fiscal Year: 2016
    ..A host molecule that influences cancer in conjunction with H. pylori is p120-catenin (p120)...
  68. Anil K Rustgi; Fiscal Year: 2016
    ..Project 1 (Rustgi, Project Leader) will focus upon the biological roles of the EGFR oncogene and cooperation with p120-catenin and p53 tumor suppressor genes in esophageal carcinogenesis, and the role of activated stromal fibroblasts ..
  69. A mouse model for p120 downregulation in cancer
    Albert Reynolds; Fiscal Year: 2009
    ..Interestingly, recent studies of nearly all of the major human tumor types also reveal frequent downregulation of p120, but the mechanism and consequences of p120 downregulation are unknown...
  70. Mechanism of p120 downregulation in human cancer
    Albert Reynolds; Fiscal Year: 2006
    ..This proposal is based primarily on three key observations, two of which constitute our preliminary data. First, p120 is required for E-cadherin stability...
  71. Role of p120ctn in Esophageal Cancer
    DOUGLAS STAIRS; Fiscal Year: 2009
    ..My research will focus on the catenin family member p120ctn and its ability to modulate tumorigenesis as well as cell migration and invasion in vitro and in vivo...
  72. Mechanisms of Sequence-Based Resistance to Viruses and Plasmids in Eubacteria
    Erik J Sontheimer; Fiscal Year: 2010
    ..CRISPR loci are accompanied by a set of cas (CRISPR-associated) genes that are likely to encode protein components of the underlying enzymatic machinery...
  73. ROLE OF KAISO IN METASTASIS
    Albert Reynolds; Fiscal Year: 2004
    ..The PI has identified a novel POZ/ZF transcription factor Kaiso that associates with catenin p120. He suggests that this protein complex may be involved in a signal pathway analogous to that associated with b-..
  74. Role of N-cadherin in Urothelial Neoplastic Progression
    Ian Summerhayes; Fiscal Year: 2004
    ..The P120 protein is associated with the JMD of cadherins and is likely an important regulator of cadherin function...
  75. p120 catenin in vascular endothelial homeostasis
    Hazel Lum; Fiscal Year: 2009
    ..We propose that endothelial p120 catenin (p120ctn), an adherens junction protein bound to VE-cadherin, may play a pivotal role in maintenance of ..
  76. Structural Investigation of Allosteric Regulation in Bacterial Carbonic Anhydrase
    JEFF CRONK; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The carbonic anhydrases (CAs) catalyze a reaction of fundamental biochemical and physiological importance, the interconversion of carbon dioxide and bicarbonate ion CO2 + H2O - All CAs ..
  77. FUNCTIONS OF RB PROTEASE(S) IN APOPTOSIS
    QING DOU; Fiscal Year: 2000
    ..In contrast, p120/ppRB was rapidly reduced just at the onset of chemotherapy-induced apoptosis, which were followed first by ..
  78. ASSEMBLY OF CAB POLYPEPTIDES
    Neil Hoffman; Fiscal Year: 1993
    ..to define and to characterize those factors which influence the assembly of chlorophyll a/b binding polypeptides (CAs polypeptides; into the light harvesting complexes associated with photosystem I (LHC I) and photosystem II (LHCII)...
  79. Mechanism of anti-phagocytosis by Yersinia pestis
    Kristiina Vuori; Fiscal Year: 2005
    ..One crucial target for YopH is thought to be the docking protein pl30cas(Cas), but the precise mechanism of its action remains unknown...