osteopontin

Summary

Gene Symbol: osteopontin
Description: secreted phosphoprotein 1
Alias: BNSP, BSPI, ETA-1, OPN, osteopontin, SPP1/CALPHA1 fusion, early T-lymphocyte activation 1, nephropontin, osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein, secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1), secreted phosphoprotein 1 variant 6, urinary stone protein, uropontin
Species: human

Top Publications

  1. ncbi Association of S100A4 and osteopontin with specific prognostic factors and survival of patients with minimally invasive breast cancer
    Suzete De Silva Rudland
    Cancer and Polio Research Fund Laboratories, School of Biological Sciences, Royal Liverpool University Hospital, UK
    Clin Cancer Res 12:1192-200. 2006
  2. pmc The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways
    Donald Courter
    Department of Radiation Oncology, Stanford University, Stanford, California, United States of America
    PLoS ONE 5:e9633. 2010
  3. doi Osteopontin, intrinsic tissue regulator of intractable inflammatory diseases
    Toshimitsu Uede
    Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    Pathol Int 61:265-80. 2011
  4. pmc Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation
    Rajeev S Samant
    Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama, USA
    Mol Cancer 6:6. 2007
  5. pmc Intracellular cleavage of osteopontin by caspase-8 modulates hypoxia/reoxygenation cell death through p53
    Hyo Jin Kim
    Creative Research Initiative Acceleration Research, School of Biological Science Bio Max Institute, Seoul National University, Seoul 151 747, Korea
    Proc Natl Acad Sci U S A 106:15326-31. 2009
  6. doi Elevated serum osteopontin levels and genetic polymorphisms of osteopontin are associated with Vogt-Koyanagi-Harada disease
    Mingliang Chu
    First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People s Republic of China
    Invest Ophthalmol Vis Sci 52:7084-9. 2011
  7. ncbi The role of osteopontin in lung disease
    ANTHONY O'REGAN
    The Pulmonary Center, R 304, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Cytokine Growth Factor Rev 14:479-88. 2003
  8. pmc Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis
    Gopal Murugaiyan
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:7480-8. 2008
  9. ncbi Osteopontin promotes integrin activation through outside-in and inside-out mechanisms: OPN-CD44V interaction enhances survival in gastrointestinal cancer cells
    Jia Lin Lee
    Institute of Biomedical Sciences, Academia Sinica, 128 Section 2 Academia Road, Taipei 11529, Taiwan
    Cancer Res 67:2089-97. 2007
  10. ncbi Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity
    S Ashkar
    Laboratory for Skeletal Disorders and Rehabilitation, Department of Orthopedic Surgery, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Science 287:860-4. 2000

Research Grants

  1. IN SITU POLYMERIZABLE GELS FOR DENTAL TISSUE ENGINEERING
    Antonios Mikos; Fiscal Year: 2002
  2. Activators of the Pyrophosphatase Activity of Alkaline Phosphatase
    Jose Luis Millan; Fiscal Year: 2007
  3. Evaluation of Recombinant Human Lactoferrin as an Osteogenic Biomaterial
    Ashley A Amini; Fiscal Year: 2013
  4. Bone matrix proteins in prostate cancer progression
    Pradip Roy Burman; Fiscal Year: 2010
  5. The regulation of leukemia-engrafting cells by the hematopoeitic Stem Cell Niche
    Siddhartha Mukherjee; Fiscal Year: 2010
  6. Farrah Kheradmand; Fiscal Year: 2016
  7. Deepak Vashishth; Fiscal Year: 2014
  8. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
  9. Jose Luis Millan; Fiscal Year: 2016
  10. RAPID MOLECULAR ACTIONS OF 1-A 25-DIHYDROXYVITAMIN D3
    DANIEL BARAN; Fiscal Year: 1999

Detail Information

Publications327 found, 100 shown here

  1. ncbi Association of S100A4 and osteopontin with specific prognostic factors and survival of patients with minimally invasive breast cancer
    Suzete De Silva Rudland
    Cancer and Polio Research Fund Laboratories, School of Biological Sciences, Royal Liverpool University Hospital, UK
    Clin Cancer Res 12:1192-200. 2006
    S100A4 and the estrogen-inducible osteopontin are alone capable of inducing angiogenesis and metastasis in rodent models for breast cancer...
  2. pmc The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways
    Donald Courter
    Department of Radiation Oncology, Stanford University, Stanford, California, United States of America
    PLoS ONE 5:e9633. 2010
    Human osteopontin (OPN), a known tumor associated protein, exists in different isoforms, whose function is unclear. It also possesses a RGD domain, which has been implicated in diverse function...
  3. doi Osteopontin, intrinsic tissue regulator of intractable inflammatory diseases
    Toshimitsu Uede
    Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Kita ku, Sapporo, Japan
    Pathol Int 61:265-80. 2011
    ..Matricellular proteins including osteopontin (OPN) and tenascin-c (TN-C) are highly expressed at the pathological foci of various inflammatory diseases...
  4. pmc Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation
    Rajeev S Samant
    Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama, USA
    Mol Cancer 6:6. 2007
    b>Osteopontin (OPN), a secreted phosphoglycoprotein, has been strongly associated with tumor progression and aggressive cancers. MDA-MB-435 cells secrete very high levels of OPN...
  5. pmc Intracellular cleavage of osteopontin by caspase-8 modulates hypoxia/reoxygenation cell death through p53
    Hyo Jin Kim
    Creative Research Initiative Acceleration Research, School of Biological Science Bio Max Institute, Seoul National University, Seoul 151 747, Korea
    Proc Natl Acad Sci U S A 106:15326-31. 2009
    b>Osteopontin (OPN) is highly expressed in cancer patients and plays important roles in many stages of tumor progression, such as anti-apoptosis, proliferation, and metastasis...
  6. doi Elevated serum osteopontin levels and genetic polymorphisms of osteopontin are associated with Vogt-Koyanagi-Harada disease
    Mingliang Chu
    First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People s Republic of China
    Invest Ophthalmol Vis Sci 52:7084-9. 2011
    b>Osteopontin (OPN) is a proinflammatory cytokine involved in chronic inflammatory diseases. This study aimed to analyze the role of OPN in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease.
  7. ncbi The role of osteopontin in lung disease
    ANTHONY O'REGAN
    The Pulmonary Center, R 304, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Cytokine Growth Factor Rev 14:479-88. 2003
    b>Osteopontin (Opn) is a multifunctional protein independently discovered by investigators from diverse scientific backgrounds and implicated in a broad array of pathological processes...
  8. pmc Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis
    Gopal Murugaiyan
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:7480-8. 2008
    b>Osteopontin (Opn) is a broadly expressed pleiotropic cytokine, and has been shown to play an important role in various autoimmune diseases, including multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (..
  9. ncbi Osteopontin promotes integrin activation through outside-in and inside-out mechanisms: OPN-CD44V interaction enhances survival in gastrointestinal cancer cells
    Jia Lin Lee
    Institute of Biomedical Sciences, Academia Sinica, 128 Section 2 Academia Road, Taipei 11529, Taiwan
    Cancer Res 67:2089-97. 2007
    b>Osteopontin (OPN) and splice variants of CD44 (CD44(V)) have independently been identified as markers for tumor progression...
  10. ncbi Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity
    S Ashkar
    Laboratory for Skeletal Disorders and Rehabilitation, Department of Orthopedic Surgery, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Science 287:860-4. 2000
    ..Mice deficient in Eta-1 (also called osteopontin) gene expression have severely impaired type-1 immunity to viral infection [herpes simplex virus-type 1 (KOS ..
  11. ncbi Polymorphisms in the osteopontin promoter affect its transcriptional activity
    Francesca Giacopelli
    Laboratory of Molecular Genetics G Gaslini Institute, Genova, Italy
    Physiol Genomics 20:87-96. 2004
    Understanding the molecular mechanisms that underlie regulation of transcription of the human osteopontin encoding gene (OPN) may help to clarify several processes, such as fibrotic evolution of organ damage, tumorigenesis and metastasis,..
  12. ncbi Osteopontin-c is a selective marker of breast cancer
    Mana Mirza
    College of Pharmacy, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Int J Cancer 122:889-97. 2008
    ..The metastasis gene osteopontin is subject to alternative splicing, which yields 3 messages, osteopontin-a, osteopontin-b and osteopontin-c...
  13. doi Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin/FAK/Akt and NF-kappaB-dependent pathway
    Yi Chin Fong
    Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan
    Lung Cancer 64:263-70. 2009
    Tumor malignancy is associated with several features such as proliferation ability and frequency of metastasis. Osteopontin (OPN), which is abundantly expressed in bone matrix, is involved in cell adhesion, migration, invasion and cell ..
  14. doi Role of osteopontin in induction of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta through the NF-kappaB and MAPK pathways in rheumatoid arthritis
    Wenxin Zheng
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Arthritis Rheum 60:1957-65. 2009
    b>Osteopontin (OPN) is a proinflammatory protein with a critical role in leukocyte migration. Although OPN has been implicated in rheumatoid arthritis (RA), its underlying mechanism remains unknown...
  15. pmc C-terminal modification of osteopontin inhibits interaction with the αVβ3-integrin
    Brian Christensen
    Protein Chemistry Laboratory, Department of Molecular Biology and Genetics, Aarhus University, DK 8000 Aarhus, Denmark
    J Biol Chem 287:3788-97. 2012
    b>Osteopontin (OPN) is a multifunctional phosphorylated protein containing the integrin binding sequence Arg-Gly-Asp through which it interacts with several integrin receptors, such as the α(V)β(3)-integrin...
  16. pmc Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage
    Yasuto Yamaguchi
    Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    J Biol Chem 288:3097-111. 2013
    b>Osteopontin (OPN), which is highly expressed in malignant glioblastoma (GBM), possesses inflammatory activity modulated by proteolytic cleavage by thrombin and plasma carboxypeptidase B2 (CPB2) at a highly conserved cleavage site...
  17. pmc Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis
    Oriol Morales-Ibanez
    Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, CIBER de Enfermedades Hepáticas y Digestivas CIBEREHD, Barcelona, Catalonia, Spain
    Hepatology 58:1742-56. 2013
    We identified, in the transcriptome analysis of patients with alcoholic hepatitis (AH), osteopontin (OPN) as one of the most up-regulated genes. Here, we used a translational approach to investigate its pathogenic role...
  18. ncbi A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5
    D D Hu
    Cancer Research Center, La Jolla Cancer Research Foundation, California 92037, USA
    J Biol Chem 270:26232-8. 1995
    b>Osteopontin (OPN) is an extracellular matrix protein that binds to integrin alpha v beta 3. Here we demonstrate that two other integrins, alpha v beta 1 and alpha v beta 5, are also receptors for OPN...
  19. ncbi Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation
    Georg F Weber
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Binney Street, Boston, Massachusetts, USA
    J Leukoc Biol 72:752-61. 2002
    ..An important mediator in this setting is the phosphoprotein osteopontin, whose secretion by activated T cells confers resistance to infection by several intracellular pathogens ..
  20. ncbi Human myeloma cells express the bone regulating gene Runx2/Cbfa1 and produce osteopontin that is involved in angiogenesis in multiple myeloma patients
    S Colla
    Hematology and BMT Center, University of Parma, Parma, Italy
    Leukemia 19:2166-76. 2005
    b>Osteopontin (OPN) is a multifunctional bone matrix glycoprotein that is involved in angiogenesis, cell survival and tumor progression...
  21. ncbi An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma
    V Takafuji
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4258, USA
    Oncogene 26:6361-71. 2007
    ..Our recent results indicate a concordant elevated expression of osteopontin (OPN) and matrix metalloproteinase-9 (MMP-9) in primary metastatic HCC...
  22. doi Osteopontin-mediated enhanced hyaluronan binding induces multidrug resistance in mesothelioma cells
    K Tajima
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Bunkyo ku, Tokyo, Japan
    Oncogene 29:1941-51. 2010
    Malignant pleural mesothelioma (MPM) is resistant to chemotherapy and thus shows a dismal prognosis. Osteopontin (OPN), a secreted noncollagenous and phosphoprotein, is suggested to be involved in the pathogenesis of MPM...
  23. doi Clinical implication and mitotic effect of CD44 cleavage in relation to osteopontin/CD44 interaction and dysregulated cell cycle protein in gastrointestinal stromal tumor
    Kai Hsi Hsu
    Institute of Clinical Medicine, National Cheng Kung University, College of Medicine, Tainan, Taiwan, ROC
    Ann Surg Oncol 17:2199-212. 2010
    CD44 and osteopontin (OPN) are functionally related molecules that, alone or in combination, play miscellaneous biological and pathophysiologic roles...
  24. pmc SPP1 genotype is a determinant of disease severity in Duchenne muscular dystrophy
    E Pegoraro
    Neuromuscular Center, Department of Neurosciences, University of Padova, 35128 Padova, Italy
    Neurology 76:219-26. 2011
    ..Substantial patient-patient variability in disease onset and progression and response to glucocorticoids is seen, suggesting genetic or environmental modifiers...
  25. pmc Osteopontin enhances HIV replication and is increased in the brain and cerebrospinal fluid of HIV-infected individuals
    Amanda Brown
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7131, USA
    J Neurovirol 17:382-92. 2011
    ..In this regard, we identified through a subtractive hybridization strategy osteopontin (OPN, SPP1, gene) an inflammatory marker, as an upregulated gene in HIV-infected primary human monocyte-derived ..
  26. pmc Osteopontin alleles are associated with clinical characteristics in systemic lupus erythematosus
    Tarak Trivedi
    Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, 5841 S Maryland Avenue, MC0930, Chicago, IL 60637, USA
    J Biomed Biotechnol 2011:802581. 2011
    Variants of the osteopontin (OPN) gene have been associated with systemic lupus erythematosus (SLE) susceptibility and cytokine profiles in SLE patients...
  27. pmc Overexpression of osteopontin, αvβ3 and Pim-1 associated with prognostically important clinicopathologic variables in non-small cell lung cancer
    Yi Jin
    Department of Pathology, The Third Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 7:e48575. 2012
    In this study, we examined the expression of osteopontin (OPN), αvβ3 and Pim-1 in non-small cell lung cancer (NSCLC) and investigated the potential clinical implications of their expression patterns in NSCLC...
  28. doi Osteopontin up-regulates critical epithelial-mesenchymal transition transcription factors to induce an aggressive breast cancer phenotype
    Neill Y Li
    Department of Surgery, Loyola University, Maywood, IL 60153, USA
    J Am Coll Surg 217:17-26; discussion 26. 2013
    ..We have previously shown in a xenograft breast cancer model that blocking osteopontin (OPN), a secreted phosphoprotein, decreases EMT...
  29. pmc Osteopontin is an initial mediator of inflammation and liver injury during obstructive cholestasis after bile duct ligation in mice
    Min Yang
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA
    Toxicol Lett 224:186-95. 2014
    b>Osteopontin (OPN) is a chemotactic factor which can be cleaved to the pro-inflammatory form by matrix metalloproteinases (MMPs)...
  30. doi Osteopontin knockdown inhibits αv,β3 integrin-induced cell migration and invasion and promotes apoptosis of breast cancer cells by inducing autophagy and inactivating the PI3K/Akt/mTOR pathway
    Hao Zhang
    Department of Breast Surgery, Central Hospital of Nanyang City, Nanyang, China
    Cell Physiol Biochem 33:991-1002. 2014
    b>Osteopontin (OPN) is associated with tumor formation, progression and metastasis, and increased OPN levels have been associated with poor survival in breast cancer...
  31. ncbi Osteopontin and mucosal protection
    J Sodek
    CIHR Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, ON, Canada
    J Dent Res 85:404-15. 2006
    ..Recent studies have indicated that osteopontin (OPN) has a pivotal role in the development of immune responses and in the tissue destruction and the ..
  32. doi Osteopontin is an activator of human adipose tissue macrophages and directly affects adipocyte function
    Maximilian Zeyda
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Endocrinology 152:2219-27. 2011
    b>Osteopontin (OPN) is highly up-regulated in adipose tissue in human and murine obesity and has been recently shown to be functionally involved in the pathogenesis of obesity-induced adipose tissue inflammation and associated insulin ..
  33. ncbi The role of osteopontin in tumor progression and metastasis in breast cancer
    Lígia R Rodrigues
    Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, Campus de Gualtar, 4710 057 Braga, Portugal
    Cancer Epidemiol Biomarkers Prev 16:1087-97. 2007
    ..b>Osteopontin is a phosphorylated glycoprotein secreted by activated macrophages, leukocytes, and activated T lymphocytes, ..
  34. doi Osteopontin promotes ovarian cancer progression and cell survival and increases HIF-1alpha expression through the PI3-K/Akt pathway
    Gang Song
    The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, China
    Cancer Sci 99:1901-7. 2008
    b>Osteopontin (OPN) is a secreted, integrin-binding matrix phosphorylated glycoprotein that is overexpressed in many advanced cancers...
  35. doi Down-regulation of osteopontin inhibits metastasis of hepatocellular carcinoma cells via a mechanism involving MMP-2 and uPA
    Rong xin Chen
    Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, PR China
    Oncol Rep 25:803-8. 2011
    b>Osteopontin (OPN) has an important role in hepatocellular carcinoma (HCC) progression and metastasis. This study was to investigate the therapeutic potential of inhibition of OPN expression...
  36. ncbi Osteopontin functionally activates dendritic cells and induces their differentiation toward a Th1-polarizing phenotype
    Andreas C Renkl
    University of Ulm, Department of Dermatology and Allergology, Maienweg 12, 89081 Ulm, Germany
    Blood 106:946-55. 2005
    b>Osteopontin (OPN) has been shown to have T helper 1 (Th1) cytokine functions in cell-mediated immunity. Deficiency of OPN is linked to a reduced Th1 immune response in autoimmunity, infectious disease, and delayed-type allergy...
  37. ncbi SPP1 polymorphisms associated with HBV clearance and HCC occurrence
    Hyoung Doo Shin
    Department of Genetic Epidemiology, SNP Genetics, Inc, Rm 1407, 14th Floor, Complex B, WooLim Lion s Valley, 371 28, Gasan Dong, Geumcheon gu, Seoul, 153 803, Republic of Korea
    Int J Epidemiol 36:1001-8. 2007
    ..We investigated the genetic polymorphisms in SPP1 to determine whether it is a potential candidate gene for a host genetic study of hepatitis B virus (HBV) clearance and HCC occurrence...
  38. ncbi Overexpression of osteopontin in hepatocellular carcinoma
    Masahiro Gotoh
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Pathol Int 52:19-24. 2002
    ..In order to identify genes involved in HCC progression, we conducted a differential display analysis and found osteopontin (OPN) to be overexpressed in HCC...
  39. pmc Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma, MDA-MB-435
    Lalita A Shevde
    University of South Alabama Mitchell Cancer Institute, Mobile, AL 36688 0002, USA
    Clin Exp Metastasis 23:123-33. 2006
    Elevated expression of osteopontin (OPN), a secreted phosphoglycoprotein, is frequently associated with many transformed cell lines...
  40. ncbi Osteopontin upregulation and polymerization by transglutaminase 2 in calcified arteries of Matrix Gla protein-deficient mice
    Mari T Kaartinen
    Faculty of Dentistry, McGill University, Strathcona Bldg Room M 72, 3640 University Street, Montreal, QC, Canada H3A 2B2
    J Histochem Cytochem 55:375-86. 2007
    ..Our aim was to examine osteopontin (OPN) expression and localization, and posttranslational processing of OPN by the crosslinking enzyme ..
  41. pmc Expression analyses of human cleft palate tissue suggest a role for osteopontin and immune related factors in palatal development
    Linda P Jakobsen
    Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, Panum Institute, Copenhagen, Denmark
    Exp Mol Med 41:77-85. 2009
    ..b>Osteopontin (SPP1) and other immune related genes were significantly higher expressed in palate tissue from patients with ..
  42. doi Clinical significance of the upregulated osteopontin mRNA expression in human colorectal cancer
    Wang Likui
    Department of Infection, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
    J Gastrointest Surg 14:74-81. 2010
    b>Osteopontin (OPN) is a phosphorylated glycoprotein which is associated with tumor progression, development, and metastasis. Recently, it has been reported that OPN is highly upregulated in a variety of human malignancies...
  43. doi Increased osteopontin plasma levels in multiple sclerosis patients correlate with bone-specific markers
    Mario H J Vogt
    Department of Clinical Chemistry and Hematology, Orbis Medical Center, Sittard Geleen, The Netherlands
    Mult Scler 16:443-9. 2010
    The pro-inflammatory cytokine osteopontin has been found to be highly expressed in multiple sclerosis lesions and plasma levels are increased during relapses in relapse-onset multiple sclerosis patients...
  44. doi Plasma osteopontin concentration correlates with the severity of hepatic fibrosis and inflammation in HCV-infected subjects
    Wenbao Huang
    Department of Infectious Diseases, Hangzhou First People s Hospital, PR China
    Clin Chim Acta 411:675-8. 2010
    The association between OPN level and the histological severity of hepatic fibrosis and inflammation in hepatitis C virus (HCV) induced liver fibrosis remains unknown.
  45. pmc Expression pattern of osteopontin splice variants and its functions on cell apoptosis and invasion in glioma cells
    Wei Yan
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People s Republic of China
    Neuro Oncol 12:765-75. 2010
    b>Osteopontin (OPN) is widely overexpressed in various cancers, including gliomas, and plays an important role in tumorigenesis. However, the expression pattern and functions of OPN splice variants expressed in gliomas remain unclear...
  46. pmc Osteopontin is a marker for cancer aggressiveness and patient survival
    G F Weber
    University of Cincinnati Academic Health Center, James L Winkle College of Pharmacy, 3225 Eden Avenue, Cincinnati, OH 45267 0004, USA
    Br J Cancer 103:861-9. 2010
    ..Meta-analysis is a valuable tool for biomarker validation. Here, we evaluate Osteopontin as a marker for tumor aggressiveness (grade, stage, early progression) and patient survival.
  47. ncbi An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers
    Quynh Thu Le
    Department of Radiation Oncology, Stanford University Medical Center, Stanford, California 94305 5847, USA
    Clin Cancer Res 12:1507-14. 2006
    ..To directly assess tumor oxygenation in resectable non-small cell lung cancers (NSCLC) and to correlate tumor pO2 and the selected gene and protein expression to treatment outcomes...
  48. pmc The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro
    L Liaw
    Department of Pathology, University of Washington, Seattle 98195
    J Clin Invest 95:713-24. 1995
    b>Osteopontin is an arginine-glycine-aspartate containing acidic glycoprotein postulated to mediate adhesion, migration, and biomineralization in diverse tissues...
  49. doi Osteopontin promotes gastric cancer metastasis by augmenting cell survival and invasion through Akt-mediated HIF-1alpha up-regulation and MMP9 activation
    Gang Song
    Cancer Research Center, Xiamen University Medical College, Xiamen, China
    J Cell Mol Med 13:1706-18. 2009
    b>Osteopontin (OPN) is a secreted, integrin-binding matrix phosphorylated glycoprotein...
  50. doi Overexpression of osteopontin induces angiogenesis of endothelial progenitor cells via the avβ3/PI3K/AKT/eNOS/NO signaling pathway in glioma cells
    Yingyi Wang
    Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, PR China
    Eur J Cell Biol 90:642-8. 2011
    ..Recent studies have shown that osteopontin (OPN) is a secreted, integrin-binding protein that contributes to glioma progression...
  51. ncbi Overexpression of osteopontin in rheumatoid synovial mononuclear cells is associated with joint inflammation, not with genetic polymorphism
    Guangwu Xu
    Health Science Center, Shanghai Institutes for Biological Sciences, Shanghai, China
    J Rheumatol 32:410-6. 2005
    b>Osteopontin (OPN) is thought to play an important role in rheumatoid synovitis...
  52. doi Osteopontin induces angiogenesis through activation of PI3K/AKT and ERK1/2 in endothelial cells
    J Dai
    International Joint Cancer Institute and General Hospital Cancer Center, The Second Military Medical University, Shanghai, PR China
    Oncogene 28:3412-22. 2009
    Angiogenesis is a key step in tumor growth and metastasis. The mechanism by which osteopontin (OPN) induces the angiogenesis of endothelial cells remains unclear...
  53. ncbi Osteopontin and colon cancer progression
    Timothy J Yeatman
    H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    Clin Exp Metastasis 20:85-90. 2003
    ..expression profiling technology to the problem of identifying new tumor markers and progression markers, and the discovery of osteopontin as the leading candidate clinical marker derived from a screen of approximately 12,000 named genes.
  54. ncbi Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning
    Qing Hai Ye
    Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China
    Nat Med 9:416-23. 2003
    ..b>Osteopontin, which was identified as a lead gene in the signature, was over-expressed in metastatic HCC; an osteopontin-..
  55. ncbi Expression and characterization of recombinant osteopontin peptides representing matrix metalloproteinase proteolytic fragments
    Yu Alice Gao
    Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive Scarborough, ME 04074, USA
    Matrix Biol 23:457-66. 2004
    b>Osteopontin (OPN) is a secreted, arginine-glycine-aspartic acid (RGD)-containing phosphoprotein proteolytically modified by members of the matrix metalloproteinase (MMP) family...
  56. pmc Reduction of elevated plasma osteopontin levels with resection of non-small-cell lung cancer
    Justin D Blasberg
    New York University School of Medicine, Department of Cardiothoracic Surgery, 530 First Ave, Suite 9V, New York, NY 10016 USA
    J Clin Oncol 28:936-41. 2010
    PURPOSE Plasma osteopontin (OPN) levels in advanced non-small-cell lung cancer (NSCLC) correlate with therapeutic response and survival, but the utility of plasma OPN for diagnosis and monitoring of early-stage NSCLC has not been ..
  57. pmc Transcription factor c-Myb promotes the invasion of hepatocellular carcinoma cells via increasing osteopontin expression
    Rong xin Chen
    Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China
    J Exp Clin Cancer Res 29:172. 2010
    Specific gene expression is tightly regulated by various transcription factors. Osteopontin (OPN) is a phosphoprotein that mediates hepatocellular carcinoma (HCC) progression and metastasis...
  58. ncbi The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease
    D Chabas
    Department of Neurology and Neurological Sciences, Beckman Center for Molecular Medicine, B002, Stanford, CA 94305, USA
    Science 294:1731-5. 2001
    ..dissected from brains of patients with multiple sclerosis (MS), indicated an abundance of transcripts for osteopontin (OPN)...
  59. ncbi Genetic polymorphisms of osteopontin in association with multiple sclerosis in Japanese patients
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    J Neuroimmunol 136:125-9. 2003
    b>Osteopontin (OPN) exhibits pleiotropic functions and abundant transcripts for OPN are present in brains of patients with multiple sclerosis (MS). The aim of this study was to investigate the role of OPN genes in the pathogenesis of MS...
  60. ncbi Osteopontin gene haplotypes correlate with multiple sclerosis development and progression
    Annalisa Chiocchetti
    Interdisciplinary Research Center of Autoimmune Diseases IRCAD and Department of Medical Sciences, A Avogadro University of Eastern Piedmont, Via Solaroli 17, I 28100 Novara, Italy
    J Neuroimmunol 163:172-8. 2005
    b>Osteopontin (OPN) is an inflammatory cytokine highly expressed in multiple sclerosis (MS) plaques...
  61. ncbi The osteopontin gene +1239A/C single nucleotide polymorphism is associated with type 1 diabetes mellitus in the Italian population
    A Chiocchetti
    Interdisciplinary Research Center of Autoimmune Diseases and Department of Medical Sciences, A Avogadro University of Eastern Piedmont, Novara, Italy
    Int J Immunopathol Pharmacol 23:263-9. 2010
    Secreted phosphoprotein 1, also known as Osteopontin (Opn), is a proinflammatory cytokine involved in the TH1 response and is highly expressed in the islets and pancreatic lymph nodes of non-obese diabetic mice before the onset of ..
  62. ncbi Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins
    Larry W Fisher
    Matrix Biochemistry Unit, Craniofacial and Skeletal Diseases Branch, NIDCR, NIH, HHS, Bethesda, Maryland 20892 4320, USA
    Connect Tissue Res 44:33-40. 2003
    ..dentin sialophosphoprotein (DSPP), enamelin (ENAM), matrix extracellular phosphoglycoprotein (MEPE), and osteopontin (OPN) are glycophosphoproteins expressed in bones and/or teeth...
  63. ncbi Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes
    Kiyoharu Ito
    Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Biochem Biophys Res Commun 357:212-7. 2007
    ..The absence of both S1P-degrading enzymes has not been reported for other cell types. Thus, erythrocytes may be specialized cells for storing and supplying plasma S1P...
  64. ncbi Beta(3) integrin expression increases breast carcinoma cell responsiveness to the malignancy-enhancing effects of osteopontin
    Kara A Furger
    Department of Oncology, University of Western Ontario, Ontario, Canada
    Mol Cancer Res 1:810-9. 2003
    b>Osteopontin (OPN) is a secreted phosphoprotein that has been associated with malignancy of breast and other cancers. OPN binds to several cell surface integrins including alpha(v)beta(3), alpha(v)beta(5), and alpha(v)beta(1)...
  65. doi Elevated plasma osteopontin level is associated with occurrence of psoriasis and is an unfavorable cardiovascular risk factor in patients with psoriasis
    Yi Ju Chen
    Department of Dermatology, Taichung Veterans General Hospital, Taichung, Taiwan
    J Am Acad Dermatol 60:225-30. 2009
    ..The association between psoriasis and cardiovascular diseases is well documented yet the underlying mechanisms remain elusive...
  66. doi Increased gastric osteopontin expression by Helicobacter pylori Infection can correlate with more severe gastric inflammation and intestinal metaplasia
    Wei Lun Chang
    Institute of Clinical Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
    Helicobacter 16:217-24. 2011
    b>Osteopontin (OPN) is involved in the gastric cancer progression. The study validated whether OPN expressions correlate with Helicobacter pylori-related chronic gastric inflammation and the precancerous change as intestinal metaplasia (IM).
  67. ncbi Expression and regulation of nicotine receptor and osteopontin isoforms in human pancreatic ductal adenocarcinoma
    Jennifer Sullivan
    Department of Surgery, Jefferson Pancreatic, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Histol Histopathol 26:893-904. 2011
    b>Osteopontin (OPN) is a secreted phospho-protein that confers on cancer cells a migratory phenotype...
  68. doi Urinary OPN excretion in children with glomerular proteinuria
    A Wasilewska
    Department of Paediatrics and Nephrology, Medical University of Bialystok, Bialystok, Poland
    Adv Med Sci 56:193-9. 2011
    The aim of the study was to investigate urinary levels and clinical significance of osteopontin (uOPN) in children with different glomerular diseases according to histological diagnosis and degree of proteinuria.
  69. doi Serum osteoprotegerin and osteopontin levels are associated with arterial stiffness and the presence and severity of coronary artery disease
    Dimitris Tousoulis
    1st Cardiology Department, University of Athens Medical School, Hippokration Hospital, Athens, Greece
    Int J Cardiol 167:1924-8. 2013
    b>Osteopontin (OPN) and osteoprotegerin (OPG) have recently emerged as key factors in both vascular remodeling and development of atherosclerosis. Arterial stiffness has an independent predictive value for cardiovascular events...
  70. doi Hypoxia-related molecules HIF-1α, CA9, and osteopontin : predictors of survival in patients with high-grade glioma
    O P Erpolat
    Department of Radiation Oncology, Medical School of Gazi University, Ankara, Turkey
    Strahlenther Onkol 189:147-54. 2013
    A high expression of hypoxia-inducible factor-1 alpha (HIF)-1α, carbonic anhydrase 9 (CA9), and osteopontin appears to be a strong prognostic indicator in many malignancies; however, their role is unclear in high-grade gliomas.
  71. doi Osteopontin O-glycosylation contributes to its phosphorylation and cell-adhesion properties
    Yoshinobu Kariya
    Department of Biochemistry, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima City, Fukushima 960 1295, Japan
    Biochem J 463:93-102. 2014
    OPN (osteopontin) is a multiphosphorylated extracellular glycoprotein, which has important roles in bone remodelling, inflammation and cancer metastasis...
  72. doi The implication of osteopontin (OPN) expression and genetic polymorphisms of OPN promoter in oral carcinogenesis
    Yu Wei Chiu
    School of Dentistry, National Yang Ming University, Taipei, Taiwan
    Oral Oncol 46:302-6. 2010
    b>Osteopontin (OPN) is an extracellular matrix protein in hard tissues. The polymorphism in promoter region of OPN gene correlates to different gene expression and might implicate potential roles in tumor progression and metastasis...
  73. ncbi Osteopontin-induced migration of human mammary epithelial cells involves activation of EGF receptor and multiple signal transduction pathways
    Alan B Tuck
    Department of Pathology, London Health Sciences Centre, University of Western Ontario, London, Ontario, Canada
    Oncogene 22:1198-205. 2003
    b>Osteopontin (OPN) is a secreted, integrin-binding glycophosphoprotein that has been implicated in breast cancer...
  74. doi Activation of RhoA and FAK induces ERK-mediated osteopontin expression in mechanical force-subjected periodontal ligament fibroblasts
    So Yeon Hong
    Department of Orthodontics, Dental Clinic, School of Medicine, Ajou University, Suwon 443 721, South Korea
    Mol Cell Biochem 335:263-72. 2010
    The precise mechanism by which Rho kinase translates the mechanical signals into OPN up-regulation in force-exposed fibroblasts has not been elucidated...
  75. doi Overexpression of osteopontin in hepatocellular carcinoma and its relationships with metastasis, invasion of tumor cells
    Fan Lin
    Department of Hepatobiliary Surgery, First Municipal People s Hospital of Guangzhou, The Affiliated Hospital of Guangzhou Medical College, Guangzhou 510180, People s Republic of China
    Mol Biol Rep 38:5205-10. 2011
    b>Osteopontin (OPN) plays an important role in metastasis and relapse of human cancer. However, the whole story of OPN relating to cancer has been far from clear untill now...
  76. pmc TGFBR2 but not SPP1 genotype modulates osteopontin expression in Duchenne muscular dystrophy muscle
    Luisa Piva
    Neuromuscular Centre, Department of Neurosciences, University of Padova, Italy
    J Pathol 228:251-9. 2012
    A polymorphism (rs28357094) in the promoter region of the SPP1 gene coding for osteopontin (OPN) is a strong determinant of disease severity in Duchenne muscular dystrophy (DMD)...
  77. pmc Identification of osteopontin as a novel ligand for the integrin alpha8 beta1 and potential roles for this integrin-ligand interaction in kidney morphogenesis
    S Denda
    Department of Physiology and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94143 0724, USA
    Mol Biol Cell 9:1425-35. 1998
    ..of unknown integrin ligands in situ and biochemical characterization of these ligands, we identified osteopontin (OPN) as a ligand for alpha8 beta1...
  78. ncbi Osteopontin is an adhesive factor for myeloma cells and is found in increased levels in plasma from patients with multiple myeloma
    Therese Standal
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Haematologica 89:174-82. 2004
    b>Osteopontin (OPN) is a non-collagenous matrix protein produced by various cells including osteoblasts, osteoclasts and several types of tumor cells...
  79. ncbi The prognostic significance of preoperative plasma levels of osteopontin in patients with hepatocellular carcinoma
    Hui Zhang
    Liver Cancer Institute and Zhongshan Hospital, Institutes of Biomedical Science, Fudan University, 180 Feng Lin Road, Shanghai, 200032, China
    J Cancer Res Clin Oncol 132:709-17. 2006
    We aimed to evaluate the prognostic value of preoperative plasma osteopontin (OPN) levels in 101 patients with hepatocellular carcinoma (HCC) who underwent liver resection. Plasma OPN levels were detected by ELISA...
  80. pmc Syndecan-4 protects against osteopontin-mediated acute hepatic injury by masking functional domains of osteopontin
    Shigeyuki Kon
    Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Kita ku, Sapporo 060 0815, Japan
    J Exp Med 205:25-33. 2008
    b>Osteopontin (OPN) is a T helper type 1 immunoregulatory cytokine that plays a critical role in various inflammatory disorders. OPN exerts proinflammatory reactions through interaction with integrin receptors...
  81. ncbi [Clinical significance of serum osteopontin in patients with multiple myeloma]
    So Young Kang
    Department of Laboratory Medicine, The East West Neo Medical Center, Kyunghee University College of Medicine, Seoul, Korea
    Korean J Lab Med 27:400-5. 2007
    ..b>Osteopontin (OPN) is a multifunctional protein that is involved in angiogenesis and bone destruction and, eventually, in ..
  82. doi Osteopontin increases migration and MMP-9 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells
    Ying Ju Chen
    School of Pharmacy, China Medical University, Taichung, Taiwan
    J Cell Physiol 221:98-108. 2009
    Tumor malignancy is associated with several features such as proliferation ability and frequency of metastasis. Osteopontin (OPN), which abundantly expressed in bone matrix, is involved in cell adhesion, migration, invasion and ..
  83. doi Osteopontin is upregulated in malignant and inflammatory pleural effusions
    Charalampos Moschos
    Applied Biomedical Research and Training Center Marianthi Simou, Department of Critical Care and Pulmonary Services, General Hospital Evangelismos, School of Medicine, University of Athens, Athens
    Respirology 14:716-22. 2009
    b>Osteopontin (OPN) is an important mediator of inflammation and cancer progression...
  84. pmc Osteopontin is associated with increased arterial stiffness in rheumatoid arthritis
    Laura Bazzichi
    Department of Internal Medicine, Division of Rheumatology, University of Pisa, Pisa, Italy
    Mol Med 15:402-6. 2009
    ..It has been suggested that osteopontin (OPN), a cytokine involved in RA pathogenesis, might have vascular effects...
  85. doi Elevated osteopontin expression and proliferative/apoptotic ratio in the colorectal adenoma-dysplasia-carcinoma sequence
    Gábor Valcz
    2nd Department of Internal Medicine, Semmelweis University, Cell Analysis Laboratory, Szentkiralyi Street 46, 1088 Budapest, Hungary
    Pathol Oncol Res 16:541-5. 2010
    ..cell ratio (PAR) in the adenoma-dysplasia-carcinoma sequence (ADCS), and to examine its association with osteopontin (OPN), a previously identified protein product related to cancer development...
  86. doi Categorical meta-analysis of Osteopontin as a clinical cancer marker
    Georg F Weber
    James L Winkle College of Pharmacy, University of Cincinnati Academic Health Center, 3225 Eden Avenue, Cincinnati, OH 45267 0004, USA
    Oncol Rep 25:433-41. 2011
    ..In particular, the cancer metastasis gene Osteopontin has been investigated extensively but it has not yet been applied to routine diagnostics...
  87. pmc Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta1
    Norihisa Nishimichi
    Cell Matrix Frontier Laboratory, Biomedical Research Unit, Hiroshima University, Minamiku, Hiroshima, Japan
    J Biol Chem 286:11170-8. 2011
    b>Osteopontin (OPN) is an integrin-binding inflammatory cytokine that undergoes polymerization catalyzed by transglutaminase 2...
  88. doi Up-regulation of osteopontin expression by aryl hydrocarbon receptor via both ligand-dependent and ligand-independent pathways in lung cancer
    Cheng Yen Chuang
    Institute of Medicine, Chung Shan Medical University, and Division of Thoracic Surgery, Department of Education and Research, Taichung Veterans General Hospital, Taichung, Taiwan, ROC
    Gene 492:262-9. 2012
    The secreted glycol-phosphoprotein OPN not only plays important roles in immune responses and tissue remodeling but is also intimately involved in tumorigenesis. It is up-regulated in various cancers and correlated with poor prognosis...
  89. doi Osteopontin promoter polymorphisms at locus -443 significantly affect the metastasis and prognosis of human hepatocellular carcinoma
    Qiong Zhu Dong
    Liver Cancer Institute and Zhongshan Hospital, Institutes of Biomedical Science, Fudan University, Shanghai, China
    Hepatology 57:1024-34. 2013
    b>Osteopontin (OPN) plays a crucial role in hepatocellular carcinoma (HCC) metastasis. However, little is known about the impact of OPN polymorphisms on cancer progression...
  90. pmc Alterations in osteopontin modify muscle size in females in both humans and mice
    Eric P Hoffman
    Department of Integrative Systems Biology, Center for Genetic Medicine Research, Children s National Medical Center, Washington, DC 20010, USA
    Med Sci Sports Exerc 45:1060-8. 2013
    An osteopontin (OPN; SPP1) gene promoter polymorphism modifies disease severity in Duchenne muscular dystrophy, and we hypothesized that it might also modify muscle phenotypes in healthy volunteers.
  91. ncbi Immunohistochemical study of osteopontin and L-selectin in a rat endometriosis model and in human endometriosis
    Kohei Odagiri
    Department of Gynecology, Omiya Medical Center, Jichi Medical School, Saitama, Japan
    Fertil Steril 88:1207-11. 2007
    To investigate the localization of the proteins osteopontin (OPN) and L-selectin (SELL).
  92. ncbi Phosphorylated osteopontin promotes migration of human choriocarcinoma cells via a p70 S6 kinase-dependent pathway
    Rania Al-Shami
    Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA
    J Cell Biochem 94:1218-33. 2005
    This study examined the role of osteopontin (OPN), a phosphorylated secreted glycoprotein, in the promotion of trophoblastic cell migration, an early event in the embryo implantation process...
  93. ncbi Association of osteopontin gene haplotypes with nephrolithiasis
    B Gao
    Department of Nephro urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Japan
    Kidney Int 72:592-8. 2007
    b>Osteopontin (OPN) is one of the glycosylated phosphoproteins produced in the kidney that can modulate nephrolithiasis. We had previously found a modest association between OPN gene polymorphisms and the risk for urinary stone formation...
  94. ncbi [Over-expression of osteopontin in non-small cell lung cancers: its clinical significance]
    Zhi Hu
    Cancer Institute Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Zhonghua Zhong Liu Za Zhi 29:591-5. 2007
    ..cDNA library constructed previously in this laboratory demonstrated that the extracellular matrix molecule osteopontin (OPN) is one of most considerably over-expressed genes in non-small cell lung cancers (NSCLCs)...
  95. doi Tumorigenic properties of alternative osteopontin isoforms in mesothelioma
    Sergey V Ivanov
    Thoracic Surgery Laboratory, Cardiothoracic Surgery Department, NYU Langone Medical Center, 462 First Ave, Bellevue Hospital, Room 15N20, NY 10016, USA
    Biochem Biophys Res Commun 382:514-8. 2009
    b>Osteopontin (SPP1) is an inflammatory cytokine that we previously characterized as a diagnostic marker in patients with asbestos-induced malignant mesothelioma (MM)...
  96. doi Osteopontin overexpression predicts poor prognosis of upper urinary tract urothelial carcinoma
    Hung Lung Ke
    Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Urol Oncol 29:703-9. 2011
    Studies indicate overexpression of osteopontin (OPN) promotes carcinogenesis, progression and metastasis of multiple human malignancies...
  97. ncbi Osteopontin (OPN) expression in thyroid carcinoma
    Juliane Briese
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Department of Pathology, University Health Network, and Ontario Cancer Institute, Toronto, Ontario, Canada
    Anticancer Res 30:1681-8. 2010
    b>Osteopontin (OPN) and its interacting partner CEA-cell adhesion molecule (CEACAM1) mediate similar biological functions and have been expressed in several types of cancer...
  98. doi Thrombin is a therapeutic target for metastatic osteopontin-positive hepatocellular carcinoma
    Yu hua Xue
    Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China
    Hepatology 52:2012-22. 2010
    We previously identified osteopontin (OPN) as a promoter and thus a potential therapeutic target for hepatocellular carcinoma (HCC) metastasis. The serine protease thrombin interacts with OPN and can modify its biological activity...
  99. pmc Prognosis of ampullary cancer based on immunohistochemical type and expression of osteopontin
    Xiang Qian Zhao
    Hospital and Institute of Hepatobiliary Surgery, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China
    Diagn Pathol 6:98. 2011
    ..Ampullary cancer (AC) was classified as pancreatobiliary, intestinal, or other subtype based on the expression of cytokeratin 7 (CK7) and cytokeratin 20 (CK20). We aimed to explore the association of AC subtype with patient prognosis...
  100. doi α9β1 integrin-mediated signaling serves as an intrinsic regulator of pathogenic Th17 cell generation
    Masashi Kanayama
    Division of Molecular Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    J Immunol 187:5851-64. 2011
    The interaction between matricellular proteins such as tenascin-C (TN-C) and osteopontin (OPN) and integrins has been implicated in the pathology of rheumatoid arthritis in which Th17 cells are recognized as primary pathogenic cells...
  101. doi Osteopontin increases the expression of β1, 4-galactosyltransferase-I and promotes adhesion in human RL95-2 cells
    Feixin Zhu
    Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, Liaoning Provincial, China
    Glycoconj J 29:347-56. 2012
    ..In the receptive phase human uterus, osteopontin (OPN) is the most highly up-regulated extracellular matrix/adhesion molecule/cytokine...

Research Grants73

  1. IN SITU POLYMERIZABLE GELS FOR DENTAL TISSUE ENGINEERING
    Antonios Mikos; Fiscal Year: 2002
    ..poly(propylene fumarate-co- ethylene glycol) (P(PF-co-EG)), these hydrogels will have a covalently bound osteopontin (OPN) peptide for enhancing bone growth while diminishing fibrous infiltration...
  2. Activators of the Pyrophosphatase Activity of Alkaline Phosphatase
    Jose Luis Millan; Fiscal Year: 2007
    ..inhibitor PPi and a natural substrate of TNAP, and from the concomitant increase in the expression of skeletal osteopontin (OPN), another calcification inhibitor...
  3. Evaluation of Recombinant Human Lactoferrin as an Osteogenic Biomaterial
    Ashley A Amini; Fiscal Year: 2013
    ..Additionally, osteocalcin, osteopontin and Runx2, alkaline phosphatase expression levels will be assessed to study the effects of the rhLF gel on cell ..
  4. Bone matrix proteins in prostate cancer progression
    Pradip Roy Burman; Fiscal Year: 2010
    ..These molecules, both secretory and commonly referred to as bone matrix proteins, are: osteopontin (OPN), an RGD-containing glycosylated phosphoprotein, and osteogenic protein-1 (OP-1 or BMP-7), a member of the ..
  5. The regulation of leukemia-engrafting cells by the hematopoeitic Stem Cell Niche
    Siddhartha Mukherjee; Fiscal Year: 2010
    ..In particular, we are interested in two candidate pathways. Osteopontin is a glycoprotein secreted by osteoblasts that is known to promote quiescence in normal hematopoietic stem ..
  6. Farrah Kheradmand; Fiscal Year: 2016
    ..preliminary data suggest the presence of a regulatory relationship between the aryl hydrocarbon receptor (AhR), osteopontin (SPP1), and peroxisome proliferator- activated receptor gamma (PPAR-?), an anti-inflammatory transcription ..
  7. Deepak Vashishth; Fiscal Year: 2014
    ..under the parent grant suggest that non-collagenous matrix (NCPs) proteins including osteocalcin (OC) and osteopontin (OPN) act as link proteins to bone mineral and influence the initiation of bone fracture at the nanoscale These ..
  8. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..role in vivo;the targets for CPB include bradykinin, C5a, the generation of plasmin and thrombin-cleaved osteopontin (OPN-Arg or OPN-R)...
  9. Jose Luis Millan; Fiscal Year: 2016
    ..In turn, high ePPi leads to a secondary elevation of skeletal osteopontin (OPN), which functions as another potent calcification inhibitor...
  10. RAPID MOLECULAR ACTIONS OF 1-A 25-DIHYDROXYVITAMIN D3
    DANIEL BARAN; Fiscal Year: 1999
    ..rapid effects of 1alpha,25-(OH)2/D3 blocks the hormone-induced increases in OC mRNA transcription, and OC and osteopontin (OPN) mRNA steady-state levels...
  11. Mineralization of the matrix in disease and health
    PETER S ROWE; Fiscal Year: 2013
    ..MEPE and DMP1 and release of ASARM-peptides from both these proteins and perhaps other SIBLING proteins (DSPP, osteopontin BSP, enamelin)...
  12. Xianzhong Meng; Fiscal Year: 2015
    ..role in TLR4-induced osteogenic responses, characterized by expression of Runx2, alkaline phosphatase (ALP) and osteopontin. Further, we found that chronic stimulation of TLR4 promotes aortic valve calcification and thickening in old ..
  13. Osteopontin and the fibrogenic response to liver injury
    Natalia Nieto; Fiscal Year: 2012
    ..b>Osteopontin (OPN) is a cytokine constitutively expressed in cells within the periportal region and it is highly induced in ..
  14. Osteopontin-mediated invasion and dissemination in central nervous system lymphom
    Han W Tun; Fiscal Year: 2013
    ..Our gene expression analysis has shown that osteopontin (OPN) is the most upregulated gene (about tenfold upregulation) in PCNSL compared to non-CNS lymphoma...
  15. Sheila A Stewart; Fiscal Year: 2015
    ..Because we have already demonstrated that osteopontin (OPN) is an important senescent stromal-derived factor in the skin, we will focus on OPN and its ability to ..
  16. THE ROLE OF FIBROBLAST-DERIVED OSTEOPONTIN IN TUMORIGENESIS
    Sheila A Stewart; Fiscal Year: 2013
    ..We identified osteopontin (OPN) as a putative stromal factor capable of enhancing preneoplastic cell proliferation and thus hypothesize ..
  17. Mitzi Nagarkatti; Fiscal Year: 2015
    ..which promote their interactions with ECs at the BBB via specific ligands, such as hyaluronic acid (HA) and/or osteopontin (OPN). Such an interaction would trigger EC injury and significant damage to the BBB...
  18. Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
    Lauren M Pachman; Fiscal Year: 2013
    ..We also found a complex gene-gene-gender interaction between the OPN and TNF-1 promoter regions in JDM children...
  19. The Role of Carboxypeptidase B and its Substrates in Rheumatoid Arthritis
    William H Robinson; Fiscal Year: 2013
    ..Recently, C3a, C5a, thrombin-cleaved osteopontin (OPN-R) and bradykinin were identified as additional substrates of CPB...
  20. Gene-Engineered and Targeted Stem Cell Therapy for Myeloma
    Selvarangan Ponnazhagan; Fiscal Year: 2013
    ..Further, osteoclasts enhance angiogenesis in concert with MM cells largely through the cooperative actions of osteopontin from osteoclasts and vascular endothelial growth factor (VEGF) from MM cells...
  21. Benjamin K Canales; Fiscal Year: 2014
    ..indicates that gastric bypass causes more glomerular injury, interstitial macrophage migration, increased osteopontin production than sham surgery or pair-fed obese controls...
  22. Crystal Associated Renal Inflammation and Treatment Options
    Saeed R Khan; Fiscal Year: 2012
    ..the activation of renin-angiotensin system (RAS), and increases in the production of macromolecules such as osteopontin (OPN) that modulate crystal formation and their retention within the kidneys...
  23. Impact of exercise on ovarian cancer prognosis
    Melinda L Irwin; Fiscal Year: 2013
    ..of estrogens, insulin, insulin-like growth factors (IGFs) C-reactive protein (CRP), leptin, CA-125, prolactin, osteopontin, and macrophage inhibitory factor...
  24. Natalia Nieto; Fiscal Year: 2016
    ..Vitamin D targets osteopontin via a vitamin D-responsive element in the osteopontin promoter...
  25. Matricellular Proteins in Trabecular Meshwork Increase Intraocular Pressure
    Douglas J Rhee; Fiscal Year: 2013
    ..The matricellular family includes SPARC, thrombospondins (TSP)-1 and -2, tenascins C and X, hevin, and osteopontin. To focus the start of our in-depth investigations, we screened the IOPs of transgenic mice with single ..
  26. Gut micro biota in patients with multiple sclerosis
    Howard L Weiner; Fiscal Year: 2012
    ..signatures as measured by antigen arrays and other immune measures in the blood of MS patients (oxysterols, osteopontin, heat shock proteins) and the gut microbiome? In summary, we believe that the investigation of the gut ..
  27. Dwight A Towler; Fiscal Year: 2016
    ..Previously, we examined the impact of inflammation, teriparatide (suppresses vascular Msx2), and osteopontin (OPN) on aortic structure, calcification, and compliance...
  28. John H Zhang; Fiscal Year: 2016
    ..promising candidates for neurovascular protection after subarachnoid hemorrhage (SAH) and one of them is osteopontin (OPN)...
  29. Incorporation of Endothelial Progenitor Cells into Placental Vaculature
    Greg A Johnson; Fiscal Year: 2013
    ..These EPCs express integrins, and use these transmembrane receptors to adhere and migrate in vitro on osteopontin (OPN) an extracellular matrix molecule with prominent expression in the placenta of both humans and pigs...
  30. An Alternate Pathway to Autoimmunity
    Thomas L Rothstein; Fiscal Year: 2012
    ..To achieve this goal, striking new findings from this laboratory concerning B cell production of osteopontin (Opn, SPP1, Eta-1) will be pursued...
  31. Vipin Kumar; Fiscal Year: 2016
    ..Notably, hepatic gene expression profiling revealed type I NKT-dependence of osteopontin (OPN) expression, while sulfatide enhances peroxisome proliferator-activator receptor-? (PPAR?) levels in liver...
  32. FASEB Summer Research Conference on Osteopontin Biology
    Neal S Fedarko; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Osteopontin is the most widely studied member of a family of multifunctional proteins that have been termed Small Integrin-Binding LIgand N-linked Glycoproteins (SIBLINGs)...
  33. Exercise Effects on Serum Biomarkers of Angiogenesis
    CATHERINE ROSE DUGGAN; Fiscal Year: 2012
    ..women on serum concentrations of the angiogenic markers vascular endothelial growth factor (VEGF), osteopontin, pigment epithelium-derived factor (PEDF) and plasminogen activator inhibitor-1(PAI-1)...
  34. FASEB SRC on Matricellular Proteins in Development, Health, and Disease
    Joanne E Murphy-Ullrich; Fiscal Year: 2013
    ..proteins have been termed matricellular proteins and include members of the thrombospondin, CCN, tenascin, osteopontin, periostin, fibulin, and SPARC families...
  35. Gabriela E Garcia; Fiscal Year: 2015
    ..blocked MF infiltrating the glomeruli and suppressed the glomerular expression of thrombospondin-1 (TSP-1) and osteopontin-1 (OPN-1). The hypothesis of this proposal is that MF A2AR activation arrests GN via suppression of MF function...
  36. Osteopontin and Collateral Vessel Growth
    WILLIAM ROBERT TAYLOR; Fiscal Year: 2012
    ..The secreted phosphoprotein osteopontin, well known as a modulator of bone remodeling, is being considered in the present study for its potential role ..
  37. Pathophysiologic Regulation of Fgf-23 in Phosphate Homeostasis: Role of Vitamin D
    Beate Lanske; Fiscal Year: 2012
    ..Moreover, we will investigate whether increased osteopontin (OPN) expression accounts for the bone mineralization defect in Fgf23-/-, Klotho-/-, and Fgf23-/-/PTH-/-...
  38. Inorganic phosphate regulated proliferation, transformation and tumorigenesis
    George R Beck; Fiscal Year: 2013
    ..signal transduction pathways, and gene expression, including cancer and metastasis related factors such as osteopontin, c-fos, Egr1 and Cox-2...
  39. Determining how trichloroethylene alters CD4+ T cell function
    Kathleen M Gilbert; Fiscal Year: 2012
    ..shown that TCE increased the production of a sheddase known as MMP-7 and a pro-inflammatory cytokine known as osteopontin. This proposal will use the MRL+/+ mouse model to test the hypothesis that TCE stimulates macrophage/dendritic ..
  40. Mechanisms of uremic vascular calcification
    Koba A Lomashvili; Fiscal Year: 2013
    ..Specifically, smooth muscle produces inhibitors of calcification such as pyrophosphate, osteopontin and matrix GLA protein but vascular calcification also may accompanied by ectopic bone formation (osteogenic ..
  41. Noncollagenous Protein Interaction in Biomineralization
    Adele L Boskey; Fiscal Year: 2013
    ..There are three specific aims: Aim 1):Demonstrate the conformational changes that occur in the binding of milk osteopontin (mOPN) and decorin (DCN), both referred to herein as "study proteins", to HA using FTIR spectroscopy...
  42. Spinal Matrix Metalloproteinases in Hyperalgesia and Allodynia
    CHRISTINA CHRISTIANSON; Fiscal Year: 2010
    ..3 (MMP-3), and associated regulatory proteins such as tissue inhibitor of metalloproteinase 1 (TIMP-1), and osteopontin in a model of inflammatory pain...
  43. Lalita A Shevde; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The oncoprotein, osteopontin (OPN) expressed by tumor cells potentiates their malignant properties, specifically by affecting their ability to grow, invade, and metastasize...
  44. Susan R Rittling; Fiscal Year: 2016
    ..The objective of this application is to understand the role of the osteopontin (OPN)-integrin axis in the host response to endodontic infection...
  45. Osteopontin regulates ubiquitin-proteasome degradation of STAT1
    Paul C Kuo; Fiscal Year: 2012
    ..we have previously demonstrated that NO feedback inhibits its own synthesis by increasing transcription of osteopontin (OPN), a potent trans-repressor of iNOS expression...
  46. AARON JAMES POLICHNOWSKI; Fiscal Year: 2015
    ..e., hypoxia, osteopontin, etc.)...
  47. Mechanism of Action of Macrophage Targeted Drugs
    KENNETH HADLOCK; Fiscal Year: 2011
    ..HIV infected individuals noted significant changes in the mRNA levels of immomodulatory proteins, including osteopontin and adenosine deaminase after in vitro PBI treatment...
  48. Glenn Walter; Fiscal Year: 2015
    ..of this ancillary study is that MR markers of muscle fibrosis and inflammation are linked to LTBP4 and osteopontin genetic variants and disease progression in DMD. To test this hypothesis we propose the following three aims...
  49. MARK DAMIAN WEWERS; Fiscal Year: 2016
    ..We provide novel evidence that osteopontin contributes to the biological response to ozone and our data suggest that osteopontin can function as an ..
  50. Innate cytokine responses that regulate autoimmunity
    Harvey Cantor; Fiscal Year: 2012
    Progress in the research funded by this grant has led to the discovery that the Osteopontin gene specifies two distinct isoforms through differential translation of a single Opn RNA species: a cytokine in T cells and a critical ..
  51. Saeed R Khan; Fiscal Year: 2015
    ..entirely different perspective on the role of macromolecules in stone formation, where it is hypothesized that osteopontin is a key player in a PILP type process...
  52. JARED MICHAEL BROWN; Fiscal Year: 2016
    ..and adverse cardiovascular events due to the resultant release of inflammatory mediators, including osteopontin (OPN)...
  53. Visualizing changes in tumor metabolism using fuctional PET imaging
    Nicholas C Denko; Fiscal Year: 2012
    ..determine if there is any increase in the level of secreted gene products of hypoxia-responsive genes such as osteopontin or galectin-1...
  54. Amato J Giaccia; Fiscal Year: 2016
    ..direction from the last submission where she was highly productive in understanding the role of hypoxia induced Osteopontin (OPN) on tumor growth and metastasis...
  55. The Role of Osteopontin in HIV-Associated Neurocognitive Disorder
    Amanda Brown; Fiscal Year: 2013
    ..b>Osteopontin (OPN) is a multifunctional cytokine-like, secreted glycophosphoprotein whose over-expression in brain, cerebral ..
  56. C Marcelo Aldaz; Fiscal Year: 2014
    ..Our current research suggests that loss of WWOX in breast cancer cells leads to unrestrained RUNX2 activity, Osteopontin overexpression and these maybe key determinants for metastasis development...
  57. SCCOR in Metabolic Syndrome and Vascular Disease
    Clay F Semenkovich; Fiscal Year: 2010
    ..In Project 6, we examine the relationships between the osteopontin gene and vascular remodeling associated with inflammation in metabolic syndrome and characterize how thBse ..
  58. AAA Disease: Mechanism, Stratification and Treatment
    Ronald L Dalman; Fiscal Year: 2010
    ..Project I (Thrombin-Cleaved Osteopontin in AAA) will examine the role of thrombin-cleaved osteopontin and its regulation in AAA, and determine if ..
  59. Osteopontin: a Novel Biomarker for Calcific Aortic Valve Diseases
    Giovanni Ferrari; Fiscal Year: 2010
    ..Project Title: Osteopontin: a Novel Biomarker for Calcific Aortic Valve Diseases The calcification of the Aortic Valve represents a ..
  60. Joint Contractures in Golden Retriever Muscular Dystrophy: A Model for Duchenne M
    PETER PHUONG NGHIEM; Fiscal Year: 2012
    ..Based upon extensive preliminary data presented in the application, the osteopontin protein becomes a major target for the molecular/functional models...
  61. Harvey Ira Pass; Fiscal Year: 2016
    ..Sensitive and specific early detection biomarkers for MM such as SMRP and Osteopontin (OPN) await validation, and prognostic biomarkers which can segregate patients at highest risk for progression/..
  62. Dietary Inorganic Phosphate as a Target for Nutritional intervention in Cancer
    George R Beck; Fiscal Year: 2010
    ..growth potential of cells and alters the expression of transformation and metastasis associated genes such as osteopontin and Egr-1...
  63. THE MINERALIZATION OF TEETH
    GEORGE H ARVEY NANCOLLAS; Fiscal Year: 2012
    ..The effect of important soluble proteins including amelogenin, osteopontin and their potentially functional peptide domains will be investigated.
  64. Linda L Phillips; Fiscal Year: 2016
    ..Pilot microarray studies revealed that osteopontin (OPN), a cytokine secreted into the ECM and reciprocally linked to MMP function, was significantly upregulated ..
  65. Imaging and Modifying Hypoxia in Head and Neck Squamous Cell Tumors
    Sydney M Evans; Fiscal Year: 2013
    ..including HIF1?, proliferation (Ki67), blood vessels (CD31), apoptosis and pAkt (radiation resistance) and osteopontin (OPN) in the urine...
  66. Aptamer targeting of osteopontin in hepatocellular cancer
    Paul C Kuo; Fiscal Year: 2013
    ..Attention has recently focused upon osteopontin (OPN) as a key mediator of HCC growth and metastasis...
  67. MCP-1 and susceptibility to active tuberculosis
    PEDRO FLORES VILLANUEVA; Fiscal Year: 2003
    ..involve increased production of MCP-l and MCP-l inhibition of IL-12 production through the down-modulation of Osteopontin (Opn) receptor alphaVbeta33 in macrophages...
  68. ADVENTITIAL RESPONSE TO VASCULAR INJURY: ESTROGEN
    Suzanne Oparil; Fiscal Year: 2003
    ..Preliminary observations have shown E2-inhibitable expression of osteopontin (OPN) in VSMCs and expression of alphav and beta3 integrins in fibroblasts in vitro and have suggested that ..
  69. Defining Molecular Markers for Tumor Hypoxia
    QUYNH THU XUAN LE; Fiscal Year: 2010
    ..In addition, it cannot be used for deeply seated tumors. We have recently shown that Osteopontin (OPN), a secreted protein, whose expression can be measured in patient blood via a simple ELISA test, can be ..
  70. ROLE OF OSTEOPONTIN IN GRANULOMATOUS INFLAMMATION
    Jeffrey Berman; Fiscal Year: 2003
    ..We have recently demonstrated the presence of the early T-cell activation gene Eta-1 (also known as osteopontin {OPN}, a bone matrix acidic glycoprotein) in active granulomatous lesions of tuberculosis rid sarcoidosis...
  71. SECRETED PHOSPHOPROTEINS ASSOCIATED WITH TUMORIGENICITY
    DONALD SENGER; Fiscal Year: 1993
    ..of this project are to determine the biological functions of secreted phospho-protein 1 (Sppl, also known as osteopontin or 2ar)...