ORC3

Summary

Gene Symbol: ORC3
Description: origin recognition complex subunit 3
Alias: LAT, LATHEO, ORC3L, origin recognition complex subunit 3, homolog of latheo, Drosophila, origin recognition complex subunit Latheo, origin recognition complex, subunit 3 honolog
Species: human

Top Publications

  1. ncbi The latex agglutination test: standardization and comparison with direct agglutination and dot-ELISA in the diagnosis of visceral leishmaniasis in India
    A K Bagchi
    Division of Parasitology, Central Drug Research Institute, Lucknow, India
    Ann Trop Med Parasitol 92:159-63. 1998
  2. ncbi Herpes simplex keratitis
    Stephen Kaye
    St Paul s Eye Unit and The Department of Medical Microbiology, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
    Prog Retin Eye Res 25:355-80. 2006
  3. ncbi [Radiation-induced bystander effect: the important part of ionizing radiation response. Potential clinical implications]
    Maria Wideł
    Zakład Radiobiologii Doświadczalnej i Klinicznej, Centrum Onkologii, Instytut im Marii Skłodowskiej Curie Oddział w Gliwicach, Gliwice
    Postepy Hig Med Dosw (Online) 63:377-88. 2009
  4. pmc Herpes simplex latent infection: quantitation of latency-associated transcript-positive neurons and reactivable neurons
    R B Tenser
    Department of Medicine (Neurology, Pennsylvania State University College of Medicine, Hershey 17033
    Yale J Biol Med 62:197-204. 1989
  5. ncbi Predictors of left atrial thrombus in mitral valve disease
    G Davison
    Department of Medicine, University of Rochester School of Medicine and Dentistry, New York
    J Gen Intern Med 6:108-12. 1991
  6. doi Cationic and neutral amino acid transporter transcript abundances are differentially expressed in the equine intestinal tract
    A D Woodward
    Department of Animal Science, Michigan State University, East Lansing 48824, USA
    J Anim Sci 88:1028-33. 2010
  7. ncbi The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans
    Marcus Guest
    School of Biological Sciences, Bassett Crescent East, University of Southampton, Southampton SO16 7PX, UK
    Int J Parasitol 37:1577-88. 2007
  8. pmc The effect of dynamic, semi-rigid implants on the range of motion of lumbar motion segments after decompression
    Tobias L Schulte
    Department of Orthopaedics, University Hospital Munster, Albert Schweitzer Strasse 33, 48149, Munster, Germany
    Eur Spine J 17:1057-65. 2008
  9. pmc Role of the L-amino acid transporter-1 (LAT-1) in mouse trophoblast cell invasion
    M K Chrostowski
    Division of Biology and Medicine, Graduate Program in Pathobiology, Brown University, Providence, Rhode Island, USA
    Placenta 31:528-34. 2010
  10. ncbi Cytochalasin D and latrunculin affect chromosome behaviour during meiosis in crane-fly spermatocytes
    A Forer
    Biology Department, York University, Downsview, Ontario, Canada
    Chromosome Res 6:533-49. 1998

Research Grants

  1. SHAOCHUNG VICTOR HSIA; Fiscal Year: 2016
  2. RECEPTOR AGGREGATION AND ITS EFFECTS
    BYRON B GOLDSTEIN; Fiscal Year: 2012
  3. Chromatin and Herpes Simplex Virus Latency
    David M Knipe; Fiscal Year: 2013
  4. HSV-1 LAT miRNAs: Neurovirulence, reactivation, mechanism
    Steven L Wechsler; Fiscal Year: 2013
  5. David C Bloom; Fiscal Year: 2014
  6. Mechanisms of Epstein-Barr Virus Persistence
    Jeffery T Sample; Fiscal Year: 2013
  7. David C Bloom; Fiscal Year: 2016
  8. Signaling in Thymocyte Selection
    Gerald R Crabtree; Fiscal Year: 2010
  9. Stephen A Rice; Fiscal Year: 2014
  10. Analysis of adaptor protein (LAT) in TCR signaling
    Weiguo Zhang; Fiscal Year: 2011

Detail Information

Publications363 found, 100 shown here

  1. ncbi The latex agglutination test: standardization and comparison with direct agglutination and dot-ELISA in the diagnosis of visceral leishmaniasis in India
    A K Bagchi
    Division of Parasitology, Central Drug Research Institute, Lucknow, India
    Ann Trop Med Parasitol 92:159-63. 1998
    ..However, the latex agglutination test (LAT) was recently reported to be a rapid and sensitive screening tool for VL and one which could be carried out at the ..
  2. ncbi Herpes simplex keratitis
    Stephen Kaye
    St Paul s Eye Unit and The Department of Medical Microbiology, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK
    Prog Retin Eye Res 25:355-80. 2006
    ..associated with histones with active transcription only from the region encoding the latency-associated transcript (LAT)...
  3. ncbi [Radiation-induced bystander effect: the important part of ionizing radiation response. Potential clinical implications]
    Maria Wideł
    Zakład Radiobiologii Doświadczalnej i Klinicznej, Centrum Onkologii, Instytut im Marii Skłodowskiej Curie Oddział w Gliwicach, Gliwice
    Postepy Hig Med Dosw (Online) 63:377-88. 2009
    ..Less is known about the bystander effect during fractionated irradiation. Thus the clinical implications of the bystander effect and its possible modification for radiotherapeutic usefulness is still under debate...
  4. pmc Herpes simplex latent infection: quantitation of latency-associated transcript-positive neurons and reactivable neurons
    R B Tenser
    Department of Medicine (Neurology, Pennsylvania State University College of Medicine, Hershey 17033
    Yale J Biol Med 62:197-204. 1989
    Dorsal root ganglion neurons, which express herpes simplex virus (HSV) latency-associated transcript (LAT) during experimental latent infection, were investigated by in situ hybridization...
  5. ncbi Predictors of left atrial thrombus in mitral valve disease
    G Davison
    Department of Medicine, University of Rochester School of Medicine and Dentistry, New York
    J Gen Intern Med 6:108-12. 1991
    OBJECTIVE: To determine the risk factors for left atrial thrombus (LAT) and the prevalence of thrombi in cases of mitral valve disease whose severity was judged to necessitate surgical intervention...
  6. doi Cationic and neutral amino acid transporter transcript abundances are differentially expressed in the equine intestinal tract
    A D Woodward
    Department of Animal Science, Michigan State University, East Lansing 48824, USA
    J Anim Sci 88:1028-33. 2010
    ..encoding for b(0,+)-type AA transporter (b(0,+)AT), cationic AA transporter-1 (CAT-1), L-type AA transporter-2 (LAT-2), and L-type AA transporter-3 (LAT-3), respectively, was determined in small and large intestinal segments of the ..
  7. ncbi The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans
    Marcus Guest
    School of Biological Sciences, Bassett Crescent East, University of Southampton, Southampton SO16 7PX, UK
    Int J Parasitol 37:1577-88. 2007
    ..However, whilst a C. elegans functional null mutant for latrophilin (lat-1) is less sensitive to the effect of emodepside on the pharynx it remains sensitive to the inhibitory effects of ..
  8. pmc The effect of dynamic, semi-rigid implants on the range of motion of lumbar motion segments after decompression
    Tobias L Schulte
    Department of Orthopaedics, University Hospital Munster, Albert Schweitzer Strasse 33, 48149, Munster, Germany
    Eur Spine J 17:1057-65. 2008
    ..Range of motion and neutral zone (NZ) were measured in flexion-extension (FE), lateral bending (LAT) and axial rotation (ROT) for each motion segment under four conditions: (1) with all stabilizing structures intact ..
  9. pmc Role of the L-amino acid transporter-1 (LAT-1) in mouse trophoblast cell invasion
    M K Chrostowski
    Division of Biology and Medicine, Graduate Program in Pathobiology, Brown University, Providence, Rhode Island, USA
    Placenta 31:528-34. 2010
    b>LAT-1 (L-type amino acid transporter 1) is a system L, Na(+)-independent amino acid transporter responsible for transport of large neutral amino acids...
  10. ncbi Cytochalasin D and latrunculin affect chromosome behaviour during meiosis in crane-fly spermatocytes
    A Forer
    Biology Department, York University, Downsview, Ontario, Canada
    Chromosome Res 6:533-49. 1998
    Living crane-fly spermatocytes were treated with 10-20 microg/ml cytochalasin D (CD) or 0.3 microg/ml latrunculin (LAT) at various stages of meiosis I...
  11. doi L-amino acid transporter-1 and boronophenylalanine-based boron neutron capture therapy of human brain tumors
    Allah Detta
    Department of Neurosurgery, Molecular Neurooncology Laboratory, The University of Birmingham, Queen Elizabeth Hospital Neuroscience Centre, Edgbaston, Birmingham, United Kingdom
    Cancer Res 69:2126-32. 2009
    The system l-amino acid transporter-1 (LAT-1) imports p-boronophenylalanine (BPA) into cells and may play a major role in the effectiveness of BPA-based boron neutron capture therapy...
  12. ncbi Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets
    B S Gross
    Department of Pharmacology, University of Oxford, UK
    Eur J Biochem 263:612-23. 1999
    ..PLC-gamma2, Syk, SH2-domain-containing leucocyte protein of 76 kDa (SLP-76), Lyn, linker for activation of T cells (LAT) and the FcR gamma-chain...
  13. ncbi Effects of dietary fiber on performance of multiparous lactating sows in a tropical climate
    D Renaudeau
    Institut National de la Recherche Agronomique, Unité de Recherches Zootechniques 97170 Petit Bourg, Guadeloupe, French West Indies, France
    J Anim Sci 81:717-25. 2003
    ..This experiment was conducted in Guadeloupe (West French Indies, lat 16 degrees N, long 61 degrees W) between October 1999 and January 2001...
  14. ncbi Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women
    Ni Zhong
    Institute of Endocrinology and Metabolism, The Second Xiang Ya Hospital, Central South University, Changsha, 86 Renmin Zhong Rd, Hunan 410011, P R China
    Clin Chim Acta 351:161-8. 2005
    ..The relationship between serum leptin concentration and BMD in Chinese women is presently unknown. We examined the relationship of serum leptin concentration with age, body weight, BMI and BMD in mainland Chinese women...
  15. pmc High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A
    K R Ayscough
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3202, USA
    J Cell Biol 137:399-416. 1997
    We report that the actin assembly inhibitor latrunculin-A (LAT-A) causes complete disruption of the yeast actin cytoskeleton within 2-5 min, suggesting that although yeast are nonmotile, their actin filaments undergo rapid cycles of ..
  16. pmc Correlation of penicillin Binding protein 2a detection with oxacillin resistance in Staphylococcus aureus and discovery of a novel penicillin binding protein 2a mutation
    Adam M Bressler
    Deparment of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA 30322, USA
    J Clin Microbiol 43:4541-4. 2005
    We compared a rapid slide latex agglutination test (LAT; Oxoid, Basingstoke, United Kingdom) that detects penicillin binding protein 2a (PBP2a) with MicroScan conventional panels (Dade Behring, West Sacramento, CA) for detection of ..
  17. ncbi Infection of BALB/c mice with a herpes simplex virus type 1 recombinant virus expressing IFN-gamma driven by the LAT promoter
    Homayon Ghiasi
    Ophthalmology Research, Cedars Sinai Burns and Allen Research Institute, Los Angeles, California 90048, USA
    Virology 302:144-54. 2002
    ..was created by inserting the gene for murine IFN-gamma under the control of the latency-associated transcript (LAT) promoter in a LAT-negative recombinant virus...
  18. ncbi A 1-year study to compare the efficacy and safety of once-daily travoprost 0.004%/timolol 0.5% to once-daily latanoprost 0.005%/timolol 0.5% in patients with open-angle glaucoma or ocular hypertension
    F Topouzis
    II Department of Ophthalmology, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Periferiaki Odos Thessalonikis, Thessaloniki 56403, Greece
    Eur J Ophthalmol 17:183-90. 2007
    ..004%/timolol 0.5% ophthalmic solution (Trav/Tim) to latanoprost 0.005%/timolol 0.5% ophthalmic solution (Lat/Tim), dosed once daily in the morning, in patients with open-angle glaucoma (OAG) or ocular hypertension (OH).
  19. pmc Overexpression of interleukin-2 by a recombinant herpes simplex virus type 1 attenuates pathogenicity and enhances antiviral immunity
    Homayon Ghiasi
    Ophthalmology Research, Cedars Sinai Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Virol 76:9069-78. 2002
    ..that expresses two copies of the murine IL-2 gene under the control of the latency-associated transcript (LAT) promoter of HSV-1 in a LAT-negative virus...
  20. ncbi The effect of addition of linoleic acid on food intake regulation in linoleic acid tasters and linoleic acid non-tasters
    Marleen M J W Kamphuis
    Department of Human Biology, Faculty of Health Sciences, Maastrict University, PO Box 616, 6200 MD Maastrict, The Netherlands
    Br J Nutr 90:199-206. 2003
    ..investigated whether healthy, non-smoking, dietary unrestrained women (n 24), divided into linoleic acid tasters (LAT, n 14) and linoleic acid non-tasters (LANT, n 10), differed in food intake regulation when linoleic acid was added ..
  21. pmc Introducing point mutations into the ATGs of the putative open reading frames of the HSV-1 gene encoding the latency associated transcript (LAT) reduces its anti-apoptosis activity
    Dale Carpenter
    The Eye Institute, University of California Irvine, School of Medicine, Irvine, CA 92697, USA
    Microb Pathog 44:98-102. 2008
    The herpes simplex virus type 1 (HSV-1) latency associated transcript (LAT) gene has anti-apoptosis activity that directly or indirectly enhances the virus's reactivation phenotype in small animal models. The first 1...
  22. pmc Rapid detection of contagious caprine pleuropneumonia using a Mycoplasma capricolum subsp. capripneumoniae capsular polysaccharide-specific antigen detection latex agglutination test
    J B March
    Department of Bacteriology, Moredun Research Institute, Penicuik EH26 0PZ, Scotland
    J Clin Microbiol 38:4152-9. 2000
    ..The coated microspheres, when used in a latex agglutination test (LAT), detected M. capricolum subsp...
  23. ncbi Evaluation of conventional & serological methods for rapid diagnosis of cryptococcosis
    D C Saha
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 127:483-8. 2008
    ..We carried out this study to compare and evaluate the conventional methods with serological methods of detection of cryptococcal meningitis...
  24. pmc Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodeling
    Troy Mitchell
    Dept of Cell Biology, Univ of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Am J Physiol Cell Physiol 295:C1354-65. 2008
    ..Treatment of neutrophils with low doses (< or = 10 microM) of the actin-depolymerizing drugs latrunculin B (Lat B) or cytochalasin B (CB) enhanced both formyl peptide receptor- and Ca(2+) ionophore-stimulated exocytosis...
  25. doi Systematics and evolution of the genus Torrubiella (Hypocreales, Ascomycota)
    Desiree Johnson
    Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331 2902, USA
    Mycol Res 113:279-89. 2009
    ..Based on the morphology of the perithecia, asci, and ascospores, it is classified in Clavicipitaceae s. lat. (Hypocreales), and is considered a close relative of Cordyceps s. 1...
  26. doi Comparative toxicity of Euphorbia milii latex and synthetic molluscicides to Biomphalaria glabrata embryos
    Eduardo C Oliveira-Filho
    Laboratory of Environmental Toxicology, Department of Biological Sciences, National School of Public Health, FIOCRUZ, Rio de Janeiro, RJ 21040 361, Brazil
    Chemosphere 81:218-27. 2010
    ..This study was undertaken to compare the developmental toxicity of a plant molluscicide (Euphorbia milii latex, LAT) with that of three synthetic molluscicidal compounds...
  27. ncbi Prevalence of HSV-1 LAT in human trigeminal, geniculate, and vestibular ganglia and its implication for cranial nerve syndromes
    D Theil
    Department of Neurology, Klinikum Grosshadern, LMU Munich, Germany
    Brain Pathol 11:408-13. 2001
    ..During latency restricted HSV-1 gene expression takes place in the form of latency-associated transcripts (LAT)...
  28. ncbi [Research of toxin and plasmids of Saccharomyces cerevisiae]
    Y Qin
    Department of Microbiology, Shandong University, Jinan 250100
    Wei Sheng Wu Xue Bao 40:105-7. 2000
    ..The SK toxin has the greatest lethal effect on the sensitive yeast strain in the lat-lag phase...
  29. ncbi Rapid serodiagnosis of leptospirosis by latex agglutination test and flow-through assay
    Tma Senthilkumar
    Department of Animal Biotechnology, Madras Veterinary College, Chennai 600 007, Tamil Nadu, India
    Indian J Med Microbiol 26:45-9. 2008
    ..In the present study, in order to develop a simple, rapid immunodiagnostic assay, one of the outer membrane proteins (OMPs), recombinant LipL41 (rLipL41) has been utilised in latex agglutination test (LAT) and flow-through assay.
  30. ncbi The anesthetic effectiveness of lidocaine-adrenaline-tetracaine gel on finger lacerations
    Nicholas J White
    Department of Pediatrics, Division of Pediatric Emergency Medicine, Eastern Virginia Medical School, Children s Hospital of the King s Daughters, Norfolk, VA 23507, USA
    Pediatr Emerg Care 20:812-5. 2004
    To determine the effectiveness of lidocaine-adrenaline-tetracaine (LAT) in providing adequate anesthesia for the repair of finger lacerations and to monitor the risk of digital ischemia following application of LAT gel to finger ..
  31. pmc LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival
    Sho Yamasaki
    Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan
    Mol Cell Biol 27:4406-15. 2007
    ..Here, we report that the transmembrane adaptors LAT and NTAL are phosphorylated slowly upon IgE stimulation and that sustained but not transient Erk activation induced ..
  32. doi Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung
    Kyoichi Kaira
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma, Japan
    Cancer Sci 100:248-54. 2009
    The purpose of this study was to evaluate the prognostic value of L-type amino acid transporter 1 (LAT 1) and 4F2 heavy chain (CD98) in patients with stage I squamous cell carcinoma of the lung...
  33. ncbi Usefulness of left ventricle dyssynchrony assessment before cardiac resynchronization implantation
    Jolana Lipoldova
    1st Internal Clinic of Cardiology and Angiology, St Anne s Faculty Hospital, Masaryk University, Brno
    Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 154:39-46. 2010
    ..Meeting contemporary guidelines approximately 30- 40% of patients do not respond to CRT (non-responders)...
  34. ncbi The persistent elevated cytokine mRNA levels in trigeminal ganglia of mice latently infected with HSV-1 are not due to the presence of latency associated transcript (LAT) RNAs
    D J Carr
    Department of Microbiology and Immunology, LSU Medical Center, New Orleans 70112 1393, USA
    Virus Res 54:1-8. 1998
    ..Since the LAT (latency associated transcript) gene is essential for wild type levels of spontaneous reactivation and is the only ..
  35. ncbi Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance
    D Torrents
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 645, 08028 Barcelona, Spain
    J Biol Chem 273:32437-45. 1998
    We have identified a new human cDNA (y+L amino acid transporter-1 (y+LAT-1)) that induces system y+L transport activity with 4F2hc (the surface antigen 4F2 heavy chain) in oocytes...
  36. ncbi CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia
    Xia Liu
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:23672-7. 2003
    We have previously shown that the heterodimer CD98/LAT-2 (LAT-2: amino acid transporter) is expressed in the basolateral membrane of intestinal epithelia and is associated with beta1 integrin (Merlin, D., Sitaraman, S., Liu, X...
  37. pmc Investigation of the mechanism by which herpes simplex virus type 1 LAT sequences modulate preferential establishment of latent infection in mouse trigeminal ganglia
    Yumi Imai
    University of California at San Francisco, 94143 0412, USA
    J Virol 83:7873-82. 2009
    ..8-kb portion of the HSV-1 genome, corresponding to the 5' end of the LAT (latency-associated transcript) coding region, is responsible for this phenotype (38, 65)...
  38. pmc Cell line-dependent variability in HIV activation employing DNMT inhibitors
    Guerau Fernandez
    Center for Cancer and Immunology Research, Children s Research Institute, Children s National Medical Center, Washington, DC, USA
    Virol J 7:266. 2010
    ..We assessed the activity of these compounds in four different Jurkat T cell-derived J-Lat cell lines (6.3, 8.4, 9.2 and 10...
  39. doi Tissue Doppler of early mitral filling correlates with simulated volume loss in healthy subjects
    Christopher L Moore
    Department of Emergency Medicine, Yale University School of Medicine, New Haven, CT, USA
    Acad Emerg Med 17:1162-8. 2010
    ....
  40. doi Thromboembolism in patients with atrial fibrillation with and without left atrial thrombus documented by transesophageal echocardiography
    Chandra K Nair
    Cardiac Center, Creighton University, Omaha, NE, USA
    Am J Ther 16:385-92. 2009
    ..events (CVEs) was investigated in 95 consecutive patients with atrial fibrillation (AF) with left atrial thrombus (LAT) diagnosed by transesophageal echocardiography (TEE) and in 131 age- and sex-matched AF patients without LAT...
  41. ncbi Gas exchange responses to continuous incremental cycle ergometry exercise in primary pulmonary hypertension in humans
    M S Riley
    Division of Respiratory and Critical Care Physiology and Medicine, St John s Cardiovascular Research Center, Torrance, CA 90509, USA
    Eur J Appl Physiol 83:63-70. 2000
    ..Mean peak VO2 [1.00 (SD 0.22) compared to 2.58 (SD 0.64) l x min(-1)] and mean VO2 at lactic acidosis threshold [LAT, 0.73 (SD 0.17) compared to 1.46 (SD 0...
  42. ncbi Do orders limiting aggressive treatment impact care for acute myocardial infarction?
    Tiffany A Radcliff
    VA Eastern Colorado Healthcare System, HSR and D TREP for Long term Care Research, Denver, CO 80220, USA
    J Am Med Dir Assoc 8:91-7. 2007
    ..The goal of this research was to determine the association between limitation of aggressive treatment (LAT) orders and guideline adherence for acute myocardial infarction (AMI).
  43. pmc The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1
    R Arudchandran
    Section on Chemical Immunology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 191:47-60. 2000
    ..The scaffold protein, linker for activation of T cells (LAT), and Rac1 (a target of Vav activity) were constitutively present in GEMs...
  44. pmc Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells
    P E Paz
    Onyx Pharmaceuticals, 3031 Research Drive, Richmond, CA 94806, USA
    Biochem J 356:461-71. 2001
    T-cell-receptor (TCR)-mediated LAT (linker for activation of T cells) phosphorylation is critical for the membrane recruitment of signalling complexes required for T-cell activation...
  45. pmc The 2-kilobase intron of the herpes simplex virus type 1 latency-associated transcript has a half-life of approximately 24 hours in SY5Y and COS-1 cells
    Darby L Thomas
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Virol 76:532-40. 2002
    The herpes simplex virus type 1 (HSV-1) 2-kb latency-associated transcript (LAT) is a stable intron, which accumulates in cells both lytically and latently infected with HSV-1...
  46. pmc Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cells
    Juan Zhang
    Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 22:8144-54. 2002
    ..cells there was dramatically impaired receptor-induced phosphorylation of multiple signaling molecules, including LAT, SLP-76, phospholipase C-gamma2, but not Vav...
  47. pmc An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing
    Bernard P Duncker
    Department of Molecular Biology, University of Geneva, Quai Ernest Ansermet 30, CH 1211 Geneva 4, Switzerland
    Proc Natl Acad Sci U S A 99:16087-92. 2002
    ..Moreover, its overexpression perturbs the regulation of late, but not early, origin firing in wild-type cells after treatment with hydroxyurea...
  48. pmc Rapid detection of contagious bovine pleuropneumonia by a Mycoplasma mycoides subsp. mycoides SC capsular polysaccharide-specific antigen detection latex agglutination test
    John B March
    Department of Bacteriology, Moredun Research Institute, Penicuik, EH26 0PZ, United Kingdom
    Clin Diagn Lab Immunol 10:233-40. 2003
    A latex agglutination test (LAT) has been developed for the diagnosis of contagious bovine pleuropneumonia (CBPP)...
  49. ncbi The flotillins are integral membrane proteins in lipid rafts that contain TCR-associated signaling components: implications for T-cell activation
    Ndaisha Slaughter
    Division of Clinical Immunology and Allergy, Department of Medicine, Los Angeles, CA 90095, USA
    Clin Immunol 108:138-51. 2003
    ..Although rafts purified from unstimulated cells demonstrated abundant Lck but inabundant LAT, rafts from stimulated cells include an abundance of both components...
  50. ncbi Separation of latent, prelatent, and native forms of human antithrombin by heparin affinity high-performance liquid chromatography
    Goran Karlsson
    Octapharma AB, SE 11275 Stockholm, Sweden
    Protein Expr Purif 33:339-45. 2004
    Latent antithrombin (LAT) is a partially denatured form of human antithrombin (AT). LAT does not inhibit clotting of the blood, but has previously been shown to inhibit angiogenesis and carcinogenesis...
  51. ncbi Relationship between the increase of effectiveness indexes and the increase of muscular efficiency with cycling power
    Karim Zameziati
    Departement des Sciences et Technologies des Activités Physiques et Sportives Unité PPEH, Universite de Saint Etienne, France
    Eur J Appl Physiol 96:274-81. 2006
    ..was possible to measure the total force (F(Tot)), including the effective (F(Tang)) and ineffective force (F (Rad + Lat))...
  52. pmc Multiplicity and plasticity of natural killer cell signaling pathways
    Sabrina Chiesa
    Centre d immunologie de Marseille Luminy, INSERM CNRS, Universite de la Mediterranee, Marseille Cedex 09, France
    Blood 107:2364-72. 2006
    ..In T and mast cells, ITAM-dependent signals are integrated by critical scaffolding elements such as LAT (linker for activation of T cells) and NTAL (non-T-cell activation linker)...
  53. ncbi Patient dosimetry measurements in 50 radiology departments in Belgium
    D Dierckx
    AV Controlatom, Olieslagerslaan, 35 B 1800 Vilvoorde, Belgium
    Radiat Prot Dosimetry 117:135-8. 2005
    ..this study, patient dosimetry results since January 2002 are presented for the following examinations: chest PA and LAT, abdomen and pelvis...
  54. ncbi Bulgarian experience in the establishment of reference dose levels and implementation of a quality control system in diagnostic radiology
    J Vassileva
    National Center of Radiobiology and Radiation Protection, Sofia 1756, Bulgaria
    Radiat Prot Dosimetry 117:131-4. 2005
    ..Reference levels for entrance surface dose (ESD) were 0.9 mGy for chest radiography (PA), 30 mGy for lumbar spine (Lat), 10 mGy for pelvis, 5 mGy for skull (AP), 3 mGy for skull (Lat) and 13 mGy for mammography...
  55. ncbi Age and sex differentially affect regional changes in one repetition maximum strength
    Jeffrey T Lemmer
    Department of Kinesiology, College of Health and Human Performance, University of Maryland, College Park, Maryland 20742, USA
    J Strength Cond Res 21:731-7. 2007
    ..When changes in strength for individual exercises were analyzed, the chest press, lat pulldown, shoulder press, and triceps pushdown were affected by both age (p < 0.05) and sex (p < 0...
  56. ncbi Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells
    Ying Wang
    Centre d immunologie de Marseille Luminy, INSERM CNRS, Universite de la Mediterranee, Parc Scientifique et Technologique de Luminy, Marseille Cedex 09, France
    J Immunol 180:1565-75. 2008
    Mutant mice where tyrosine 136 of linker for activation of T cells (LAT) was replaced with a phenylalanine (Lat(Y136F) mice) develop a fast-onset lymphoproliferative disorder involving polyclonal CD4 T cells that produce massive amounts ..
  57. pmc The methylmercury-L-cysteine conjugate is a substrate for the L-type large neutral amino acid transporter
    Zhaobao Yin
    Department of Pediatrics, Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Neurochem 107:1083-90. 2008
    ..Treatment of LAT-1 over-expressing CHO-k1 cells with L-cysteine-conjugated MeHg was also associated with increased leakage of ..
  58. pmc Imatinib mesylate inhibits CD4+ CD25+ regulatory T cell activity and enhances active immunotherapy against BCR-ABL- tumors
    Nicolas Larmonier
    Department of Pediatrics, Steele Children s Research Center, University of Arizona, Tucson, AZ 85724, USA
    J Immunol 181:6955-63. 2008
    ..Analysis of Treg TCR-induced signaling cascade indicated that imatinib inhibited phosphorylation of ZAP70 and LAT. Substantiating these observations, imatinib treatment of mice decreased Treg frequency and impaired their ..
  59. doi Eighteen-year follow-up of a retrospective study of HLA antibody on kidney graft survival
    P C Lee
    Medical College, National Cheng Kung University, Tainan, Taiwan
    Transplant Proc 41:121-3. 2009
    ..This retrospective study used Lambda antigen tray-mixed (LAT-M) screening and Luminex HLA class I and II specificity assay to re-examine the impact of pretransplantation HLA ..
  60. pmc Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection
    Sophie Reuse
    Laboratory of Molecular Virology, Institut de Biologie et de Médecine Moléculaires IBMM, Universite Libre de Bruxelles ULB, Gosselies, Belgium
    PLoS ONE 4:e6093. 2009
    ..Using the latently-infected U1 monocytic cell line and latently-infected J-Lat T-cell clones, we here demonstrated a strong synergistic activation of HIV-1 production by clinically used histone ..
  61. doi Sero-epidemiological investigation of bovine toxoplasmosis in traditional and smallholder cattle production systems of Tanga Region, Tanzania
    Luuk B Schoonman
    Tanga Dairy Trust, Box 1720, Tanga, Tanzania
    Trop Anim Health Prod 42:579-87. 2010
    ..seroprevalence of the disease in animals in Tanzania, a study, using the modified Eiken latex agglutination test (LAT), was conducted from May 2003 to January 2004 to determine the prevalence of antibody to T...
  62. pmc TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation
    Björn F Lillemeier
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA
    Nat Immunol 11:90-6. 2010
    ..the spatio-temporal dynamics of T cell antigen receptor (TCR) complexes and linker for activation of T cells (Lat), a key adaptor molecule in the TCR signaling pathway, in T cell membranes using high-speed photoactivated ..
  63. doi Brain regions involved in the learning and application of reward rules in a two-deck gambling task
    E Hartstra
    Institute of Psychology, Leiden University, The Netherlands
    Neuropsychologia 48:1438-46. 2010
    ..Lateral PFC (lat-PFC) and Anterior Cingulate Coretex (ACC)/pre-supplementary motor area (pre-SMA) were most active for early ..
  64. doi LAT--an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic
    Vaclav Horejsi
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    FEBS J 277:4383-97. 2010
    ..The most important leukocyte transmembrane adaptor protein is LAT (linker for activation of T cells), which is critically involved in T cell receptor signalling, but also plays ..
  65. pmc T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component
    Claudia Brockmeyer
    T Cell Signalling Laboratory, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, United Kingdom
    J Biol Chem 286:7535-47. 2011
    ..phosphorylation of THEMIS depends on the presence of the scaffold proteins Linker for activation of T cells (LAT) and SH2 domain-containing lymphocyte protein of 76 kDa (SLP-76)...
  66. pmc Weight loss and reduced body temperature determine humane endpoints in a mouse model of ocular herpesvirus infection
    F Claire Hankenson
    Department of Pathobiology, School of Veterinary Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Am Assoc Lab Anim Sci 52:277-85. 2013
    ..Here, BALB/c mice were inoculated ocularly with either a wildtype (LAT(+)) or mutant (LAT(-)) strain of HSV1...
  67. ncbi Current state of Marek's disease virus microRNA research
    Julie A Hicks
    Department of Animal Science, North Carolina State University, Raleigh, NC 27695, USA
    Avian Dis 57:332-9. 2013
    ..MDV-1 miRNA have been identified, one located near the MEQ gene and one within the latency-associated transcript (LAT)...
  68. doi A new treatment for human malignant melanoma targeting L-type amino acid transporter 1 (LAT1): a pilot study in a canine model
    Shinya Fukumoto
    Veterinary Internal Medicine, Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Biochem Biophys Res Commun 439:103-8. 2013
    ..A comparative study of LAT expression was performed in 48 normal tissues, 25MM tissues and five cell lines established from MM...
  69. doi Small RNA cloning and sequencing strategy affects host and viral microRNA expression signatures
    Grégoire Stik
    Transcription, Lymphome Viro induit, UMR7261, Universite de Tours, UFR Sciences et Techniques, Parc Grandmont, 37200 Tours, France
    J Biotechnol 181:35-44. 2014
    ..One of the mature miRNA derived from the latency-associated-transcript (LAT), mdv1-miR-M7-5p, showed the highest variation...
  70. ncbi Search for photon-linelike signatures from dark matter annihilations with H.E.S.S
    A Abramowski
    Universitat Hamburg, Institut fur Experimentalphysik, Luruper Chaussee 149, D 22761 Hamburg, Germany
    Phys Rev Lett 110:041301. 2013
    ..part of the Milky Way halo and for extragalactic observations, complementing recent limits obtained with the Fermi-LAT instrument at lower energies. No statistically significant signal could be found...
  71. doi Comparison between laparoscopic partial nephrectomy and laparoscopic ablation therapy: a meta-analysis
    Cheng Qiang Mo
    Department of Urology, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    Minim Invasive Ther Allied Technol 23:317-25. 2014
    ..a meta-analysis of the literature evaluating comparisons on the peri-operative and oncological outcomes between laparoscopic partial nephrectomy (LPN) and laparoscopic ablation therapy (LAT) in the treatment of small renal masses (SRMs).
  72. pmc LAT software induced savings on medical costs of alcohol addicts' care--results from a matched-pairs case-control study
    Mihajlo Jakovljevic
    Department of Pharmacology and Toxicology The Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
    PLoS ONE 9:e111931. 2014
    Lesch Alcoholism Typology (LAT) is one of the most widely used clinical typologies of alcohol addiction. Study tested whether introduction of LAT software in clinical practice leaded to improved outcomes and reduced costs...
  73. doi THEMIS: a critical TCR signal regulator for ligand discrimination
    Nicholas R J Gascoigne
    Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 5 Science Drive 2, Singapore 117597, Singapore Electronic address
    Curr Opin Immunol 33:86-92. 2015
    ..is recruited to the proximity of signaling T-cell antigen receptors (TCR) by association with the membrane scaffold LAT. However, its molecular role remained an enigma until recently...
  74. doi L-amino acid transporter 1 may be a prognostic marker for local progression of prostatic cancer under expectant management
    Nobuyuki Yanagisawa
    Department of Pathology, Kitasato University School of Medicine, Kanagawa, Japan
    Cancer Biomark 15:365-74. 2015
    Oncocytic L-amino acid transporter (LAT) 1 could be a target of new molecular therapy against malignancies.
  75. pmc Increased neurovirulence and reactivation of the herpes simplex virus type 1 latency-associated transcript (LAT)-negative mutant dLAT2903 with a disrupted LAT miR-H2
    Xianzhi Jiang
    Virology Research, Gavin Herbert Eye Institute and Department of Ophthalmology, University of California Irvine, School of Medicine, Irvine, CA, 92697, USA
    J Neurovirol 22:38-49. 2016
    At least six microRNAs (miRNAs) appear to be encoded by the latency-associated transcript (LAT) of herpes simplex virus type 1 (HSV-1)...
  76. doi Optimal Loads for Power Differ by Exercise in Older Adults
    Melanie Potiaumpai
    1Laboratory of Neuromuscular Research and Active Aging, Department of Kinesiology and Sports Sciences, University of Miami, Coral Gables, Florida and 2Center on Aging, Miller School of Medicine, University of Miami, Miami, Florida
    J Strength Cond Res 30:2703-12. 2016
    ..001) for both machines. The LAT pull-down optimal load range was between 30 and 50%, with peak power occurring at 40% (p < 0.001)...
  77. doi Neothalassius, a new genus of Parathalassiinae (Diptera: Dolichopodidae s.lat.) from the Pacific coast of South America
    Scott E Brooks
    Diptera Unit, Canadian National Collection of Insects, Invertebrate Biodiversity, Agriculture and Agri Food Canada, K W Neatby Building, 960 Carling Avenue, Ottawa, Ontario, K1A 0C6, Canada Email
    Zootaxa 4066:311-22. 2016
    ..nov. and Neothalassius villosus sp. nov., are described from rocky shorelines along the Pacific seacoast of South America. The phylogenetic placement of Neothalassius within the subfamily Parathalassiinae is discussed. ..
  78. pmc The divorce of Sporothrix and Ophiostoma: solution to a problematic relationship
    Z W De Beer
    Department of Microbiology and Plant Pathology, Forestry and Agricultural Research Institute FABI, University of Pretoria, Pretoria 0002, South Africa
    Stud Mycol 83:165-91. 2016
    ..b>lat. Were the one fungus one name principles adopted in the Melbourne Code to be applied to Ophiostoma s. lat...
  79. pmc The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary transcript
    G C Perng
    Ophthalmology Research Laboratories, Cedars Sinai Medical Center Research Institute, Los Angeles, California 90048, USA
    J Virol 70:976-84. 1996
    The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential for efficient spontaneous reactivation of HSV-1 from latency. We report here that although the LAT gene is 8.3 kb in length, the first 1...
  80. ncbi Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling
    W Zhang
    Laboratory of Cellular and Molecular Biology, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Biol Chem 275:23355-61. 2000
    The linker for activation of T cells (LAT) is a critical adaptor molecule required for T cell antigen receptor (TCR)-mediated signaling and thymocyte development...
  81. ncbi Regulation of FcepsilonRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells
    Kiyonao Sada
    Division of Proteomics, Department of Genome Sciences, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Blood 100:2138-44. 2002
    ..Furthermore, antigen stimulation induced the association of 3BP2-SH2 domain with LAT and other signaling molecule complexes in the RBL-2H3 cells...
  82. ncbi Evaluation of polymerase chain reaction (PCR) for diagnosing Haemophilus influenzae b meningitis
    Sunit C Singhi
    Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    Ann Trop Paediatr 22:347-53. 2002
    ..detecting Hib in cerebrospinal fluid (CSF) was evaluated and compared with culture and a latex agglutination test (LAT) in a hospital-based prospective surveillance...
  83. pmc Analysis of herpes simplex virus ICP0 promoter function in sensory neurons during acute infection, establishment of latency, and reactivation in vivo
    R L Thompson
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0524, USA
    J Virol 77:12319-30. 2003
    ..This same 562-bp promoter/reporter cassette, when placed in the context of a latency-associated transcript (LAT) null mutant, resulted in >95% concordance of expression of beta-Gal and ICP0 during reactivation in vivo...
  84. pmc L-type amino acid transporter-1 overexpression and melphalan sensitivity in Barrett's adenocarcinoma
    Jules Lin
    Section of General Thoracic Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Neoplasia 6:74-84. 2004
    The L-type amino acid transporter-1 (LAT-1) has been associated with tumor growth. Using cDNA microarrays, overexpression of LAT-1 was found in 87...
  85. ncbi Korean adult male voxel model KORMAN segmented from magnetic resonance images
    Choonsik Lee
    Innovative Technology Center for Radiation Safety, Hanyang University, HIT Bldg, 17 Haengdang, Sungdong, Seoul 133 791, Korea
    Med Phys 31:1017-22. 2004
    ..40% were observed in organ absorbed doses for some organs including bone surface (AP), stomach (PA), and testes (LAT) for low photon energy...
  86. ncbi A comparison of three techniques to obtain root coverage on mandibular incisors
    Randall J Harris
    J Periodontol 76:1758-67. 2005
    ..Multiple variations on the subepithelial connective tissue graft have been shown to produce good clinical results. The goal of this study was to compare three variations in the treatment of recession on mandibular incisors...
  87. ncbi The effect of paragigantocellularis lateralis lesion on conditioned place preference (CPP) in presence or absence of alpha2 adrenergic agonist (clonidine) in male rats
    H Fathi-Moghaddam
    Department of Physiology, School of Medicine, Jundishapur Medical Sciences, University of Ahwaz, Ahwaz, Iran
    Acta Physiol Hung 93:33-40. 2006
    ..8, Lat +/- 1.86 and Depth = 10.5)...
  88. doi Production and characterization of highly tumor-specific rat monoclonal antibodies recognizing the extracellular domain of human L-type amino-acid transporter 1
    Yoshiya Ohno
    Cell Biology Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, Kinki University, 4 1 Kowakae 3 chome, Higashiosaka shi, Osaka 577 8502, Japan
    Cancer Sci 99:1000-7. 2008
    L-type large amino acid transporter (LAT) 1, the first light chain (lc) of cluster of differentiation 98 (CD98) to be identified, is associated with the heavy chain (hc) of CD98 and expressed on the surface of various tumor cells ..
  89. pmc Anillin: a pivotal organizer of the cytokinetic machinery
    Gilles R X Hickson
    Department of Biochemistry and Biophysics, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, CA 94158, USA
    Biochem Soc Trans 36:439-41. 2008
    ..Studies using the inhibitor of F-actin assembly, Lat A (Latrunculin A), have revealed that these associations occur independently of F-actin; indeed they appear to be ..
  90. doi Single measurement reliability and reproducibility of volitional and magnetically-evoked indices of neuromuscular performance in adults
    C Minshull
    School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom
    J Electromyogr Kinesiol 19:1013-23. 2009
    ..of force development (RFD(V); RFD(E)), peak force (PF(V); P(T)F(E)), and compound muscle action potential latency (LAT(E)) and amplitude (AMP(E)) were obtained...
  91. pmc Spatial association of signaling proteins and F-actin effects on cluster assembly analyzed via photoactivation localization microscopy in T cells
    Chih Jung Hsu
    Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e23586. 2011
    ..The average radii of SLP76 and LAT MCs were found to decrease, whereas ZAP70 MC radii remained relatively constant...
  92. pmc The requirement of linker for activation of T cells in the primary and memory responses of CD8 T cells
    Chih Wen Ou-Yang
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 190:2938-47. 2013
    Linker for activation of T cells (LAT) is a transmembrane adaptor protein that links TCR engagement to downstream signaling events...
  93. pmc The hidden burden of trichinellosis in Vietnam: a postoutbreak epidemiological study
    Nga Vu Thi
    Parasitology Section, National Centre for Veterinary Diagnosis, 11 78 Giai Phong, Phuong Mai, Dong da, Hanoi, Vietnam Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, 133 Salisburylaan, 9820 Merelbeke, Belgium
    Biomed Res Int 2013:149890. 2013
    A cross-sectional study was conducted in Muong Lat town (Thanh Hoa province, North Vietnam), following the confirmed diagnosis of trichinellosis in six patients from that town who had eaten hunted wild boar meat during the Vietnamese ..
  94. doi Session ratings of perceived exertion responses during resistance training bouts equated for total work but differing in work rate
    Justin A Kraft
    1Department of Health, Physical Education, and Recreation, Missouri Western State University, St Joseph, Missouri and 2Department of Health, Physical Education and Recreation, University of North Alabama, Florence, Alabama
    J Strength Cond Res 28:540-5. 2014
    ..Participants performed 3 exercise bouts of bench press, lat pull-down, overhead press, upright row, triceps extension, and biceps curl at 60% of predetermined 1 repetition ..
  95. pmc Integration of computational modeling with membrane transport studies reveals new insights into amino acid exchange transport mechanisms
    Kate L Widdows
    Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, Manchester, United Kingdom St Mary s Hospital and Central Manchester University Hospitals National Health Service Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom Bioengineering Science Research Group, Faculty of Engineering and the Environment, University of Southampton, Southampton, United Kingdom Mathematical Institute, Oxford University, Oxford, United Kingdom and Faculty of Medicine, and Institute for Life Sciences, University of Southampton, Southampton, United Kingdom
    FASEB J 29:2583-94. 2015
    ..Both L-type amino acid transporter (LAT)1 and LAT2 subtypes of system L were distributed to MVM, with L-serine transport attributed to LAT2...
  96. pmc Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS
    William Y C Huang
    Department of Chemistry, University of California, Berkeley, CA 94720
    Proc Natl Acad Sci U S A 113:8218-23. 2016
    ..Here, we reconstitute phosphotyrosine-mediated assembly of extended linker for the activation of T cells (LAT):growth factor receptor-bound protein 2 (Grb2):Son of Sevenless (SOS) networks, derived from the T-cell receptor ..
  97. ncbi Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T lymphocytes in rheumatoid arthritis
    S I Gringhuis
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 164:2170-9. 2000
    ..T lymphocytes exert severely impaired phosphorylation of the adaptor protein linker for activation of T cells (LAT), a crucial component of the TCR-mediated signaling pathways...
  98. ncbi Generation of medial and lateral dorsal body domains by the pannier gene of Drosophila
    M Calleja
    Centro de Biologia Molecular, CSIC UAM, Spain
    Development 127:3971-80. 2000
    ..genetic domains in the dorsal region of each segment: a medial (MED) region where pnr is expressed and a lateral (LAT) region where it is not. The homeobox gene iroquois (iro) is expressed in the LAT region...
  99. ncbi Differentiating the ligament of Marshall from the pulmonary vein musculature potentials in patients with paroxysmal atrial fibrillation: electrophysiological characteristics and results of radiofrequency ablation
    C T Tai
    Department of Medicine, National Yang Ming University School of Medicine, Taipei Veterans General Hospital, Taiwan, R O C
    Pacing Clin Electrophysiol 23:1493-501. 2000
    ..PAF) can be initiated by ectopic atrial beats originating from the pulmonary vein (PV) or left atrial tract (LAT) within the ligament of Marshall (LOM)...
  100. pmc Latent herpesvirus infection in human trigeminal ganglia causes chronic immune response
    Diethilde Theil
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Am J Pathol 163:2179-84. 2003
    ..The presence of immune cells correlated constantly with the occurrence of the HSV-1 latency-associated transcript (LAT) and only irregularly with the presence of latent VZV protein...
  101. pmc Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL
    Minghua Zhu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 200:991-1000. 2004
    ..LAB is capable of rescuing thymocyte development in LAT-deficient mice. To study the in vivo function of LAB, LAB-deficient mice were generated...

Research Grants63

  1. SHAOCHUNG VICTOR HSIA; Fiscal Year: 2016
    ..responsive elements (TREs) in the regulatory regions of HSV-1 thymidine kinase (TK), latency-associated transcript (LAT), and infected cell protein 0 (ICP0)...
  2. RECEPTOR AGGREGATION AND ITS EFFECTS
    BYRON B GOLDSTEIN; Fiscal Year: 2012
    ..In addition we will add LAT, Grb2 and Sos1, which form extended complexes posing a major computational challenge...
  3. Chromatin and Herpes Simplex Virus Latency
    David M Knipe; Fiscal Year: 2013
    ..We hav defined the role of viral gene products such as LAT and ICP0 in modulating the chromatin structure during lytic and latent infection, but further basic information is ..
  4. HSV-1 LAT miRNAs: Neurovirulence, reactivation, mechanism
    Steven L Wechsler; Fiscal Year: 2013
    ..The HSV-1 latency associated transcript (LAT), the only viral gene abundantly expressed during latency, is involved in both the virus'neurovirulence and ..
  5. David C Bloom; Fiscal Year: 2014
    ..RNA immunoprecipitation (RIP) data indicate that the LAT 2...
  6. Mechanisms of Epstein-Barr Virus Persistence
    Jeffery T Sample; Fiscal Year: 2013
    ..expression of the nine EBV latency-associated proteins and a subset of the viral miRNAs - the latency III (Lat III) program...
  7. David C Bloom; Fiscal Year: 2016
    ..lytic genes are repressed and only one transcript is abundantly transcribed, the latency associated transcript (LAT)...
  8. Signaling in Thymocyte Selection
    Gerald R Crabtree; Fiscal Year: 2010
    ..sort signals to distinct fates in T cells must operate upstream of Bim, Calcineurin and Erk, yet downstream of CD3, LAT, VAV and other molecules required of CD3, LAT, VAV and other molecules required Calcineurin for both positive and ..
  9. Stephen A Rice; Fiscal Year: 2014
    ..ICP27 regulates other viral genes DE and L genes, as well as the gene for the viral latency-associated transcript (LAT), which we have recently shown is regulated by ICP27 at the level of mRNA stability...
  10. Analysis of adaptor protein (LAT) in TCR signaling
    Weiguo Zhang; Fiscal Year: 2011
    ..One of the prominently phosphorylated proteins is LAT (linker for activation of T cells)...
  11. Carl F Ware; Fiscal Year: 2016
    ..maintain latency in mice genetically deficient in HVEM, BTLA or LIGHT and the viral latency- associated transcript (LAT) uniquely upregulates HVEM expression in latently infected ganglia...
  12. Donald M Coen; Fiscal Year: 2016
    ..We have defined the role of viral gene products such as LAT and ICPO in modulating the chromatin structure during lytic and latent infection, but further basic information is ..
  13. Development of a mouse model of obesity in pregnancy
    Thomas Jansson; Fiscal Year: 2009
    ..transporter isoforms 1 and 3, System A isoforms SNAT 1, 2 and 4 and L-system amino acid transporter isoforms LAT 1, LAT2 and 4F2hc...
  14. Adaptor molecules in lymphocyte signaling
    Weiguo Zhang; Fiscal Year: 2010
    ..While some adaptors, such as LAT and SLP-76, have a positive and essential role in T cell receptor-mediated signaling and thymocyte development, ..
  15. Corneal HSV-1: Newly discovered LAT miRNAs and latency
    Steven L Wechsler; Fiscal Year: 2011
    ..The HSV-1 LAT (latency associated transcript) gene is required for wild type (wt) spontaneous reactivation...
  16. Characterization of a novel rabbit herpes simplexvirus: a possible model for unde
    LING J JIN; Fiscal Year: 2010
    ..is that they become latent in the TG with no gene expression, except for the latency associated transcript gene (LAT). The role of LAT during latency is still not well understood...
  17. MECHANISM OF LATENCY OF HERPES SIMPLEX VIRUS
    Nigel Fraser; Fiscal Year: 2007
    ..We will continue to examine the function of stable intron of the latency associated transcript (LAT) genes...
  18. Microenvironmental changes on NK cell responses to primary HSV-1
    Andrew J Tarr; Fiscal Year: 2011
    ..e., ICP0, ICP4, ICP27, and LAT) will be examined as a readout of SDR effects on viral replication...
  19. Arthur Weiss; Fiscal Year: 2016
    ..1) tyrosine phosphorylation of the TCR-associated immunoreceptor tyrosine-based activation motifs (ITAMs) and of LAT;and, (Project #2) the activation of Ras downstream of LAT by the guanine nucleotide exchange factors (GEFs) RasGRP ..
  20. The role of RIAM in T cell immunity and tolerance
    Vassiliki A Boussiotis; Fiscal Year: 2013
    ..of endogenous RIAM abrogated these events, although phosphorylation of ZAP-70 and formation of the SLP-76-LAT signalosome remained unaffected...
  21. Randall J Cohrs; Fiscal Year: 2016
    ..alphaherpesviruses, including herpes simplex-1 (HSV-1), transcribe a single latency associated transcript (LAT)...
  22. ARTHUR ROBERT SALOMON; Fiscal Year: 2014
    ..In particular, the placement of these phosphorylation events relative to the critical pathway protein SLP76 and LAT will be examined in detail through a collection of domain and point mutants, allowing for the precise placement of ..
  23. ERIC M VERDIN; Fiscal Year: 2014
    ..Agents that synergize with Aza-CdR to reactivate HIV in the J-Lat model of HIV latency will be tested in a primary cell models of latency and in latently infected cells from HIV-..
  24. The role of tonic signal-input in stable gene profiles
    Jeroen Roose; Fiscal Year: 2010
    ..mouse models, I will determine the effects of inducible removal of the TCR signaling molecules ZAP-70 and LAT (alone or combined with g-radiation) on constitutive gene expression profiles and maintenance of a differentiated T ..
  25. MARK MORRIS DAVIS; Fiscal Year: 2014
    ..on distinct "protein islands" on T cell surfaces and that these TCR-containing structures join together with LAT-containing islands during T cell activation to form signaling microclusters...
  26. Leucine Type Amino Acid Transport In Gliomas
    MARK MYRON GOODMAN; Fiscal Year: 2012
    ..amino acid (AA) that moves across tumor capillaries involving primarily the "L" large-neutral AA transport system (LAT)...
  27. Aging, Herpesviruses, and Alzheimer's Disease
    James Hill; Fiscal Year: 2007
    ..Aim 2: (A) Quantify the HSV-1 latency-associated transcripts (LAT) in tissues positive for HSV-1 DNA. We have new evidence that HSV-1 LAT can be quantitated in human brain regions...
  28. Elucidating mechanisms governing transcriptional regulation of the human LAT gene
    Timothy S Finco; Fiscal Year: 2013
    ..The Principal Investigator's (PI's) laboratory studies transcriptional regulation of the human LAT gene, which encodes a transmembrane adaptor protein linking receptor engagement to the activation of numerous ..
  29. OCULAR HSV INFECTION--LATENCY AND REACTIVATION
    STEVEN WECHSLER; Fiscal Year: 2000
    ..Reactivations can cause recurrent corneal disease leading to blindness. LAT, the only transcriptionally active viral gene during latency, is essential for efficient spontaneous reactivation...
  30. The Role of HNF4alpha in Cell Proliferation
    Linh Vuong; Fiscal Year: 2013
    ..The P1 isoforms (HNF411/12) are expressed exclusively in lat embryo, postnatal and adult livers while the P2 isoforms (HNF417/18) are expressed only in the fetal liver...
  31. CORNEAL HSV-1: A NOVEL VIRULENCE/REACTIVATION GENE
    STEVEN WECHSLER; Fiscal Year: 2004
    ..Recurrent herpes simplex virus type 1 (HSV-1) infection is a major cause of viral induced blindness. LAT, the only HSV-1 gene previously thought active during latency, is important for efficient reactivation of HSV-1...
  32. Regulation of HSV-1 gene expression and reactivation by insulator protein CTCF
    Donna M Neumann; Fiscal Year: 2013
    ..latency in sensory neurons, where abundant viral gene expression is limited to the latency associated transcript (LAT)...
  33. Angus Wilson; Fiscal Year: 2014
    ..not expressed to any significant level and viral transcription is limited to the latency-associated transcripts (LAT) that processed into a stable 2.0-kb intron and handful of viral microRNAs...
  34. Andrea S Bertke; Fiscal Year: 2014
    ..neurons to cause some portion of recurrent HSV disease, regulated in part by the latency-associated transcript (LAT)...
  35. Amnon Altman; Fiscal Year: 2016
    ..In 2006, we discovered that anergic T cells display a selective defect in the palmitoylation of the adaptor LAT, resulting in intracellular retention of LAT and failure to promote TCR-induced T cell activation...
  36. Studies on NikD, a Nikkomycin Biosynthetic Enzyme
    MARILYN S JORNS; Fiscal Year: 2010
    ..is a labile compound that is derived from L-lysine in a reaction catalyzed by an L-lysine-"-aminotransferase (LAT)...
  37. CYCLIN T AND HIV1 TAT TRANSACTIVATION
    Katherine Jones; Fiscal Year: 2009
    ..Therefore, we will also assess the role of SKIP and associated corepressors in the silencing of viral transcription in J-Lat cells, a model of HIV-1 latency.
  38. Corneal HSV-1: LAT's Anti-Apoptosis Activity and Latency
    Steven L Wechsler; Fiscal Year: 2013
    ..b>LAT, the only viral gene abundantly transcribed during latency enhances the reactivation phenotype by blocking ..
  39. JOHN JOSEPH MCARDLE; Fiscal Year: 2015
    ..of Michigan will continue data collection activities for this longitudinal study and produce datasets in co{lat}oration with the University of Southern California for public release...
  40. GENE TRANSFER TO AND EXPRESSION IN NEURONS IN VIVO
    NIGEL WILLIAM FRASER; Fiscal Year: 2013
    ..application we wish to extend the utility of HSV virus vectors by developing an expression cassette utilizing the LAT promoter and the LAT gene chromatin boundaries from HSV...
  41. Alcohol and Depression among Middle-Aged and Older Adults
    MICHAEL T WINDLE; Fiscal Year: 2012
    ..10-year prospective data (baseline and two successive five-year follow-up points) from the Lives across Time (LAT) Study are proposed using the parent data from the LAT...
  42. ANNA RUTH CLIFFE; Fiscal Year: 2014
    ..The latency-associated transcript (LAT) encodes a family of non-coding RNAs and is the only viral gene product expressed to high levels during latency...
  43. Jon C D Houtman; Fiscal Year: 2014
    ..is to comprehensively examine the Grb2- mediated complexes that form at an SH2 domain ligand, the adaptor protein LAT. Our central working hypothesis is that Grb2 forms cooperative interactions with both LAT and individual SH3 domain ..
  44. Outpatient treatment for portal hypertension
    Elijah M Bolotin; Fiscal Year: 2010
    ..Our long term goal, in collaboration with our commercialization partner LAT-Pharma LLC, is to develop a long-acting formulation of terlipressin that can be ideally administered by sub-Q ..
  45. HSV LATENCY AND MECHANISMS OF GENE SILENCING
    Joseph Glorioso; Fiscal Year: 2000
    ..While transcription of the viral IE genes is silenced, an RNA referred to as latency associated transcript (LAT) is transcribed. LAT is considered a stable intron...
  46. JONATHAN TALBOT BUTCHER; Fiscal Year: 2014
    ..this system we will test how aortic valve endothelial cells (VEC) and interstitial cells (VIC) respond to early and lat calcified tissue environments. Our application has two Aims...
  47. Analysis of adaptor protein (LAT) in TCR signaling
    Weiguo Zhang; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Linker for activation of T cells (LAT) is a palmitoylated transmembrane adaptor protein that is indispensable for signaling through the TCR...
  48. RONALD BRUCE HIRSCHL; Fiscal Year: 2016
    ..Over the lat decade we addressed this problem for adult respiratory failure resulting in the development of an implantable ..
  49. Opportunistic Oral HSV-- Mechanisms of Reactivation
    Craig Miller; Fiscal Year: 2006
    ..genes: alpha 0, alpha 4, alpha 22, alpha 27, and alpha 47, beta genes: ul9 ul23, ul39 and the gamma gene ul48 and LAT) are transcriptionally induced by heat stress and forskolin treatment in the absence of other viral gene products...
  50. Signaling in thymic selection
    Fotini Gounari; Fiscal Year: 2010
    ..previously linked to negative-selection including a transient activation of Erk and sustained over-activation of Lat, and Jnk. This leads to induction of Bim, which mediates clonal deletion...
  51. VIRAL PERSISTENCE--STUDIES WITH HERPES SIMPLEX VIRUS
    Lawrence Stanberry; Fiscal Year: 1999
    ..Recent evidence indicates that the HSV-2 LAT transcription unit is an important determinant of the pattern of recurrent genital herpes...
  52. BLOOD BRAIN BARRIER LARGE NEUTRAL AMINO ACID TRANSPORTER
    William Pardridge; Fiscal Year: 2003
    ..This work will study the pathophysiological expression of the large neutral amino acid transporter (LAT) at the blood-brain barrier...
  53. Diane Lidke; Fiscal Year: 2016
    ..the kinetics of Syk adaptor protein binding to the signaling complex;and 3) To determine the cluster stability of LAT and the interplay between Fc?RI and LAT signaling patches...
  54. Function and High-Resolution of an APC superfamily amino acid transporter
    Bliss Forbush; Fiscal Year: 2009
    The aminoacid/ polyamine/organocation (APC) superfamily of transporters includes human LAT and CAT amino acid transporters as well the Na-K-Cl, Na-Cl and K-Cl cation-chloride cotransporters (CCCs)...
  55. SIGNIFICANCE OF MEMBRANE PHOSPHOLIPID ASYMMETRY
    Bertram Lubin; Fiscal Year: 1999
    ..synthesis of a lipid membrane around the active enzyme, purify the membrane bound 42 kDa lysoPL-acyltransferase (LAT) that reacylates PLs...
  56. Optimization of an SPF Mouse Facility: Animal Care and Personnel Safety
    Mary Ann McCrackin; Fiscal Year: 2009
    ..The laboratory animal technicians have achieved certification (3 LATg, 1 LAT, 2 ALAT) by the American Association for Laboratory Animal Science (AALAS) and received the 2006 Northern Rocky ..
  57. STRUCTURE/FUNCTION OF HSV1 ICP4
    Neal Deluca; Fiscal Year: 2003
    ..The ICP4, LAT and Orf P (L/ST) promoters are examples of ICP4 repressed promoters...
  58. Chromatin Dynamics in a Model of Latent HIV Infection
    Steven E Kauder; Fiscal Year: 2010
    ..Our laboratory has developed the J-Lat cell lines, a model system for the study of HIV latency in vitro...
  59. Regulation of T cell anergy by palmitoyl acyl transferases
    Amnon Altman; Fiscal Year: 2010
    ..palmitoylation and, consequently, lipid raft localization and function, of linker for activation of T cells (LAT)...
  60. Characterization of Lck and Associated Proteins
    MARIETTA HARRISON; Fiscal Year: 2006
    ..Using mutant versions of Lck and structural analogs of palmitic acid and farnesol designed to either target Lck, LAT (critical adaptor protein) and Ras (a key member of the Ras Erk Map kinase pathway) to lipid rafts or prevent their ..
  61. Ocular HSV-1: Turning On/Off LAT Expression in Latency
    Guey Chuen Perng; Fiscal Year: 2003
    ..Although the HSV-1 LAT gene is essential for efficient spontaneous reactivation, it remains unclear whether LAT's main latency related ..
  62. SIGNAL TRANSDUCTION IN THE IMMUNE SYSTEM-FASEB CONF.
    Gary Koretzky; Fiscal Year: 2003
    ..will cover a spectrum of topics from protein and lipid kinases and phosphatases to adapter proteins (SLP-76, LAT, ADAP, 3BP-2 etc.), plasma membrane biology and effector enzymes in basic biology and disease settings...
  63. MOLECULAR GENETICS OF LEARNING AND MEMORY IN DROSOPHILA
    TIMOTHY TULLY; Fiscal Year: 1999
    DESCRIPTION: The investigators are pursueing the molecular characterization of four new Drosophila genes, latheo, linotte, nalyot and golovan, all of which were identified in a P element (transposon) insertional mutagenesis for mutants ..