OPN1LW

Summary

Gene Symbol: OPN1LW
Description: opsin 1, long wave sensitive
Alias: CBBM, CBP, COD5, RCP, ROP, long-wave-sensitive opsin 1, cone dystrophy 5 (X-linked), opsin 1 (cone pigments), long-wave-sensitive, red cone opsin, red cone photoreceptor pigment, red-sensitive opsin
Species: human

Top Publications

  1. ncbi Expression of cAMP response element binding protein-binding protein in the song control system and hypothalamus of adult European starlings (Sturnus vulgaris)
    C J Auger
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore MD 21218 2686, USA
    J Neuroendocrinol 14:805-13. 2002
  2. doi Comparison of chain- and plate-loaded bench press training on strength, joint pain, and muscle soreness in Division II baseball players
    Kevin McCurdy
    Department of Health Physical Education and Recreation, Texas State University, San Marcos, Texas, USA
    J Strength Cond Res 23:187-95. 2009
  3. pmc LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF
    Katherine A Fitzgerald
    Division of Infectious Disease and Immunology, Department of Medicine, The University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Exp Med 198:1043-55. 2003
  4. ncbi Molecular genetics of human color vision: the genes encoding blue, green, and red pigments
    J Nathans
    Science 232:193-202. 1986
  5. doi Thyroid hormone controls cone opsin expression in the retina of adult rodents
    Anika Glaschke
    Max Planck Institute for Brain Research, Neuroscience Center, Goethe Universitat, 60528 Frankfurt Main, Germany
    J Neurosci 31:4844-51. 2011
  6. pmc Identification of novel retinal target genes of thyroid hormone in the human WERI cells by expression microarray analysis
    Yan Liu
    Division of Medical Genetics, Departments of Medicine and Genome Sciences, University of Washington, Box 357720, Seattle, WA 98195 7720, USA
    Vision Res 47:2314-26. 2007
  7. pmc Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12
    K Ito
    Thoracic Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
    Mol Cell Biol 20:6891-903. 2000
  8. ncbi Protein coregulators that mediate estrogen receptor function
    T Ratajczak
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
    Reprod Fertil Dev 13:221-9. 2001
  9. ncbi Against women: are we looking after our general practitioners? GPs' views of the 1990 part-time contract
    J Littlewood
    South Bank University, London
    J R Soc Promot Health 119:85-8. 1999
  10. ncbi 1,25-Dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts
    Sungtae Kim
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    J Bone Miner Res 20:305-17. 2005

Research Grants

  1. RAJESH K ANEJA; Fiscal Year: 2016
  2. Role of histone acetyltransferases in memory storage and synaptic plasticity
    MARCEL ANDRE ESTEVEZ; Fiscal Year: 2012
  3. Role of Cited2 in Hematopoiesis
    Yu Chung Yang; Fiscal Year: 2011
  4. Histone Acetylation and Insulin Gene Expression
    Sabire Ozcan; Fiscal Year: 2010
  5. Acetylation-Dependent IFN Signal Transduction
    Y Eugene Chin; Fiscal Year: 2010
  6. Coregulatory factor modulation of CREB activity
    ROLAND P KWOK; Fiscal Year: 2010
  7. Zhonghui Guan; Fiscal Year: 2016
  8. John S Davis; Fiscal Year: 2014
  9. Chemical Modulators for p53 Functions in Transcriptional Regulation
    SYED S MUJTABA; Fiscal Year: 2012
  10. CBP Bromodomain Antagonists Block Androgen Receptor in Prostate Cancer
    SYED S MUJTABA; Fiscal Year: 2010

Detail Information

Publications432 found, 100 shown here

  1. ncbi Expression of cAMP response element binding protein-binding protein in the song control system and hypothalamus of adult European starlings (Sturnus vulgaris)
    C J Auger
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore MD 21218 2686, USA
    J Neuroendocrinol 14:805-13. 2002
    ..The coactivator, cAMP response element binding protein (CREB)-binding protein (CBP), has been implicated in both androgen and oestrogen receptor transactivation...
  2. doi Comparison of chain- and plate-loaded bench press training on strength, joint pain, and muscle soreness in Division II baseball players
    Kevin McCurdy
    Department of Health Physical Education and Recreation, Texas State University, San Marcos, Texas, USA
    J Strength Cond Res 23:187-95. 2009
    The purpose of this study was to investigate the effects of chain- (CBP) and plate-loaded (PBP) bench press training on measures of strength, shoulder pain, and muscle soreness in Division II baseball players...
  3. pmc LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF
    Katherine A Fitzgerald
    Division of Infectious Disease and Immunology, Department of Medicine, The University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Exp Med 198:1043-55. 2003
    ..These studies suggest that TRIF and TRAM both function in LPS-TLR4 signaling to regulate the MyD88-independent pathway during the innate immune response to LPS...
  4. ncbi Molecular genetics of human color vision: the genes encoding blue, green, and red pigments
    J Nathans
    Science 232:193-202. 1986
    ..Green pigment genes vary in number among color-normal individuals and, together with a single red pigment gene, are proposed to reside in a head-to-tail tandem array within the X chromosome...
  5. doi Thyroid hormone controls cone opsin expression in the retina of adult rodents
    Anika Glaschke
    Max Planck Institute for Brain Research, Neuroscience Center, Goethe Universitat, 60528 Frankfurt Main, Germany
    J Neurosci 31:4844-51. 2011
    ....
  6. pmc Identification of novel retinal target genes of thyroid hormone in the human WERI cells by expression microarray analysis
    Yan Liu
    Division of Medical Genetics, Departments of Medicine and Genome Sciences, University of Washington, Box 357720, Seattle, WA 98195 7720, USA
    Vision Res 47:2314-26. 2007
    ..We identified 12 novel retinal targets of TH, including 10 up-regulated genes (OPN1MW, OPN1LW, TIMP3, RP1L1, GNGT2, CRX, ARR3, GCAP1, IMPDH1, and PDE6C) and 2 down-regulated genes (GNGT1 and GNB3)...
  7. pmc Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12
    K Ito
    Thoracic Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, London, United Kingdom
    Mol Cell Biol 20:6891-903. 2000
    ..Furthermore, we show that GR acts both as a direct inhibitor of CREB binding protein (CBP)-associated HAT activity and also by recruiting HDAC2 to the p65-CBP HAT complex...
  8. ncbi Protein coregulators that mediate estrogen receptor function
    T Ratajczak
    Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia
    Reprod Fertil Dev 13:221-9. 2001
    ..of selected members of the multifunctional steroid receptor coactivator family and the cointegrators, p300/CBP and P/CAF...
  9. ncbi Against women: are we looking after our general practitioners? GPs' views of the 1990 part-time contract
    J Littlewood
    South Bank University, London
    J R Soc Promot Health 119:85-8. 1999
    ..This particularly affects women General Practitioners. Whilst the RCP policy statement addresses education and training for general practice, the question of not losing out in relation ..
  10. ncbi 1,25-Dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts
    Sungtae Kim
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    J Bone Miner Res 20:305-17. 2005
    ....
  11. ncbi Temporal formation of distinct thyroid hormone receptor coactivator complexes in HeLa cells
    D Sharma
    Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA
    Mol Endocrinol 14:2001-9. 2000
    ..Coactivators implicated in ligand-dependent activation by TR include p300, the CREB-binding protein (CBP), members of the p160/SRC family, and the multisubunit TR-associated protein (TRAP) complex...
  12. ncbi Treatment of hypertensive patients according to the conventional or ambulatory pressure: a progress report on the APTH trial. APTH Investigators. Ambulatory Blood Pressure and Treatment of Hypertension
    L Bieniaszewski
    Klinisch Laboratorium Hypertensie, Inwendige Geneeskunde Cardiologie U Z Gasthuisberg
    Acta Cardiol 51:243-51. 1996
    ..sitting diastolic pressure from 80 through 89 mm Hg on conventional sphygmomanometry (conventional blood pressure [CBP] group), and one in which a daytime (from 10 to 20 h) diastolic pressure from 80 through 89 mm Hg had to be ..
  13. ncbi [Effect of continuous blood purification and thymosin alpha1 on the cellular immunity in patients with severe sepsis: a prospective, randomized, controlled clinical trial]
    Yi Nan Li
    Intensive Care Unit, the First Hospital of Foshan, Foshan 528000, Guangdong, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:139-42. 2009
    To discuss the effect of continuous blood purification (CBP), thymosin alpha1 and combined therapy on cellular immunity in patients with severe sepsis.
  14. doi Empiric antibiotics are justified for infants with respiratory syncytial virus lower respiratory tract infection presenting with respiratory failure: a prospective study and evidence review
    Daniel Levin
    Department of Pediatrics, Children s Hospital at Dartmouth, Dartmouth Medical School, Lebanon, NH, USA
    Pediatr Crit Care Med 11:390-5. 2010
    ..We hypothesized the composite diagnosis of concomitant bacterial pneumonia (CBP) is common in lower risk infants with RSV who present in respiratory failure...
  15. ncbi In vivo complex formation of PU.1 with HDAC1 associated with PU.1-mediated transcriptional repression
    F Kihara-Negishi
    Department of Cell Genetics, Sasaki Institute, 2 2, Kanda Surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Oncogene 20:6039-47. 2001
    ..It was unlikely that the repression was due to sequestration of a limited amount of CBP/p300 nor pCAF, because overexpression of these co-activators did not relieve PU...
  16. ncbi Home blood pressure normalcy: the Didima study
    G S Stergiou
    Hypertension Center, Third University Department of Medicine, Sotiria Hospital, Athens, Greece
    Am J Hypertens 13:678-85. 2000
    ..4%). Clinic blood pressure (CBP) was measured on two visits (triplicate measurements, mercury sphygmomanometer) and HBP on 3 workdays (duplicate ..
  17. ncbi Gene amplification and expression of the steroid receptor coactivator SRC3 (AIB1) in sporadic breast and endometrial carcinomas
    M Glaeser
    Department of Gynecology and Obstetrics, Heinrich-Heine-University, Duesseldorf, Germany
    Horm Metab Res 33:121-6. 2001
    ..It binds to nuclear receptors in a ligand-dependent fashion and recruits other factors such as CBP and p300 to the transactivation complex...
  18. ncbi [Determining factors in decisions regarding cardio-pulmonary resuscitation in patients with cerebral hemorrhage]
    J R Ara
    , Hospital Miguel Servet, Zaragoza,
    Rev Neurol 25:1518-20. 1997
    ..RESULTS: We identified 73 patients, 50 men and 23 women. Their mean age was 61 years. RCP was performed in 25 patients (34%). A logistic regression revealed that age (OR 0...
  19. ncbi Stability of YACs containing ribosomal or RCP/GCP locus DNA in wild-type S. cerevisiae and RAD mutant strains
    K Kohno
    Department of Molecular and Cellular Biology for Pharmaceutical Sciences, Kyoto Pharmaceutical University, Japan
    DNA Res 1:191-9. 1994
    ....
  20. ncbi Rubinstein-Taybi syndrome with epidermal nevus: a case report
    C Schepis
    Unit of Dermatology and Department of Pediatrics, Oasi Institute (IRCCS, Troina, Italy
    Pediatr Dermatol 18:34-7. 2001
    ..facies, and mental retardation caused by mutations in the transcriptional coactivator CREB binding protein (CBP)...
  21. ncbi [Correlation between XRCC2 and XRCC5 single nucleotide polymorphisms and drug-sensitivity of human lung cancer cells]
    Rui Wang
    Department of Thoracic Surgery, Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050011, China
    Zhonghua Yi Xue Za Zhi 88:3059-62. 2008
    ..To study the associations between XRCC2 and XRCC5 single nucleotide polymorphisms (SNPs) and chemosensitivity of human lung cancer cells...
  22. doi Corn expressing an Escherichia coli-derived phytase gene: comparative evaluation study in broiler chicks
    E K D Nyannor
    Department of Animal Science, Purdue University, West Lafayette, IN 47907 2054, USA
    Poult Sci 87:2015-22. 2008
    The efficacy of corn expressing an Escherichia coli-derived gene (corn-based phytase; CBP) and an E...
  23. ncbi Transactivation mechanisms of mouse clock transcription factors, mClock and mArnt3
    S Takahata
    Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan
    Genes Cells 5:739-47. 2000
    ..Yeast and mammalian two-hybrid systems revealed that CBP and p300 interacted with mArnt3 via the CREB binding domain...
  24. ncbi Clinical analysis of 43 cases of chronic benzene poisoning
    Shouren Kuang
    Guangdong Poison Control Center, 165 Xin gang Road, Guangzhou 510300, PR China
    Chem Biol Interact 153:129-35. 2005
    Benzene can result in bone marrow suppression. Chronic benzene poisoning (CBP) can be found among workers with excessive benzene exposure...
  25. ncbi Characterisation of cellulose-binding proteins that are involved in the adhesion mechanism of Fibrobacter intestinalis DR7
    J Miron
    Metabolic Unit, Volcani Center, Bet Dagan, Israel
    Appl Microbiol Biotechnol 51:491-7. 1999
    Cellulose-binding proteins (CBP) isolated from cell envelopes of the cellulolytic bacterium Fibrobacter intestinalis strain DR7 were studied in order to investigate the adhesion mechanism...
  26. ncbi In-house preparation of technetium 99m-labeled human serum albumin for evaluation of protein-losing gastroenteropathy
    Joseph C Hung
    Nuclear Pharmacy Laboratories and PET Radiochemistry Facility, Department of Radiology, Mayo Clinic, Rochester, Minn 55905 0001, USA
    J Am Pharm Assoc (Wash) 42:57-62. 2002
    ..To develop an in-house preparation method for technetium 99m-labeled human serum albumin (99mTc-HSA) to meet the clinical need for gastrointestinal (GI) protein loss evaluation in our institution...
  27. ncbi Rab coupling protein (RCP): a novel target of progesterone action in primate endometrium
    V S Patil
    Primate Biology Department, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Parel, Mumbai 400 012, India
    J Mol Endocrinol 35:357-72. 2005
    ..DD2 sequence was found to be homologous to the sequence of the carboxyl terminal region of Rab coupling protein (RCP), a recently discovered protein involved in intracellular vesicular trafficking...
  28. ncbi Occlusal changes following posterior tooth loss in adults. Part 3. A study of clinical parameters associated with the presence of occlusal interferences following posterior tooth loss
    Helen L Craddock
    Restorative Dentistry, Leeds Dental Institute, Clarendon Way, Leeds, UK
    J Prosthodont 17:25-30. 2008
    ..The purpose of this study was to determine clinical parameters associated with the presence of retruded contact position (RCP) contacts and occlusal interferences associated with posterior tooth loss.
  29. ncbi Properties of cattle bone powder-coated composite particles as high-performance and open column liquid chromatographic column packings
    F Honda
    PHD Inc, Hokkaido, Japan
    J Chromatogr A 813:21-33. 1998
    Cattle bone powder (CBP) from natural resources was employed as a protein adsorbent instead of chemically synthesized hydroxyapatite (HA). Though a small amount of impurities was detected, CBP possessed a crystallinity similar to HA...
  30. ncbi Analysis of occlusal contacts in different types of prosthodontic appliances, Eichner classifications, presence RCP-ICP slide and the type of occlusion
    J Stipetić
    Department of Prosthodontic, School of Dental Medicine, University of Zagreb, Croatia
    Coll Antropol 25:311-6. 2001
    ..weak) with respect to the type of occlusion (canine guided, group function or balanced) and the presence of the RCP-ICP slide...
  31. ncbi Cell separation based on the reversible interaction between calmodulin and a calmodulin-binding peptide
    R J Colinas
    The Wadsworth Center, New York State Department of Health, Albany 12201 0509, USA
    J Immunol Methods 212:69-78. 1998
    ..separation system based on the calcium-dependent interaction of calmodulin (CM) with a calmodulin-binding peptide (CBP) has been developed. The prototype of this system utilizes an indirect method to label the target cell population...
  32. ncbi Role of the transcriptional coactivator CBP/p300 in linking basic helix-loop-helix and CREB responses for follicle-stimulating hormone-mediated activation of the transferrin promoter in Sertoli cells
    J Chaudhary
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Biol Reprod 65:568-74. 2001
    ..Such an interaction can be mediated by transcriptional integrators such as CREB-binding protein (CBP) and/or p300 and may stabilize the binding of trans-acting factors to their respective cis-elements...
  33. ncbi Synergistic antifungal activity of two chitin-binding proteins from spindle tree (Euonymus europaeus L.)
    Karolien P B Van den Bergh
    Laboratory of Phytopathology and Plant Protection, Katholieke Universiteit Leuven, Willem de Croylaan 42, 3001 Leuven, Belgium
    Planta 219:221-32. 2004
    ..Both the small hevein-like chitin-binding protein (Ee-CBP) and the classical class-I chitinase (Ee-chitinase) possess antifungal properties, Ee-CBP being far more potent ..
  34. ncbi Corn expressing an Escherichia coli-derived phytase gene: a proof-of-concept nutritional study in pigs
    E K D Nyannor
    Department of Animal Science, Purdue University, West Lafayette, IN 47907 2054, USA
    J Anim Sci 85:1946-52. 2007
    ..investigate the concept that the addition of corn expressing an Escherichia coli-derived gene (corn-based phytase; CBP) to a P-deficient diet would improve growth performance and P utilization in pigs. An E...
  35. ncbi [Penetrability of amikacin into prostate tissues in rat models of chronic bacterial prostatitis]
    He Wang
    Department of Microbiology, Guiyang Medical College, Guiyang, Guizhou 550004, China
    Zhonghua Nan Ke Xue 14:583-9. 2008
    ..To establish the rat model of chronic bacterial prostatitis and investigate the penetrability of amikacin to chronic inflammatory prostatic tissues...
  36. pmc E1A-mediated repression of progesterone receptor-dependent transactivation involves inhibition of the assembly of a multisubunit coactivation complex
    Y Xu
    Population Council, The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 20:2138-46. 2000
    ..a multisubunit receptor-coactivator complex containing two previously described coactivators, CREB-binding protein (CBP) and steroid receptor coactivator 1 (SRC-1, a member of the p160 family of coactivators), in nuclear extracts of ..
  37. ncbi Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles
    S Chakraborty
    Department of Pathology and The Cancer Center, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Biol Chem 276:44936-43. 2001
    ..The second group includes the two co-activators cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF), both of which have histone acetyltransferase (HAT) activity...
  38. ncbi Clinical application of retrograde cerebral perfusion for brain protection during surgery of ascending aortic aneurysm--a report of 50 cases
    Peiqing Dong
    J Extra Corpor Technol 34:101-6. 2002
    ..To protect the brain, deep hypothermic circulatory arrest (DHCA) combined with retrograde cerebral perfusion (RCP) through superior vena cava (N = 50) and simple DHCA (N = 15) were used during the procedure...
  39. ncbi Expression of steroid receptor coactivators and corepressors in human endometrial hyperplasia and carcinoma with relevance to steroid receptors and Ki-67 expression
    Junko Uchikawa
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    Cancer 98:2207-13. 2003
    ..as coactivators (steroid receptor coactivator 1 [SRC-1] and p300/cyclic AMP-response element-binding protein (p300/CBP]) and corepressors (nuclear receptor corepressor [NCoR] and silencing mediator for retinoid and thyroid-hormone ..
  40. ncbi NF-kappaB/PPAR gamma and/or AP-1/PPAR gamma 'on/off' switches and induction of CBP in colon adenocarcinomas: correlation with COX-2 expression
    Panagiotis A Konstantinopoulos
    Department of Biochemistry, School of Medicine, University of Patras, 26110, Patras, Greece
    Int J Colorectal Dis 22:57-68. 2007
    ..a signaling intermediate of NF-kappaB pathway), PPAR gamma, cyclic AMP-response element binding-binding protein (CBP, a known AP-1, NF-kappaB, and PPAR gamma transcriptional coactivator), epidermal growth factor receptor (EGF-R), ..
  41. ncbi Assessing neuromuscular block at the larynx: the effect of change in resting cuff pressure and a comparison with video imaging in anesthetized humans
    K J Girling
    University Department of Anaesthesia, University Hospital, Queen s Medical Centre, Nottingham, United Kingdom
    Anesth Analg 88:426-31. 1999
    ..In this study, we evaluated the decrease in resting cuff pressure (RCP) after the administration of rocuronium and the effect of this decrease on the assessment of NMB, and we compared ..
  42. ncbi Acetylation of importin-alpha nuclear import factors by CBP/p300
    A J Bannister
    Department of Pathology, Wellcome CRC Institute, University of Cambridge, Cambridge, CB2 1QR, UK
    Curr Biol 10:467-70. 2000
    ..We asked whether the acetylase CREB-binding protein (CBP) could acetylate proteins not directly involved in transcription...
  43. ncbi Expression of cAMP response element binding protein (CREB)-binding protein (CBP) and the implication in retinoic acid-inducible transcription activation in human salivary gland adenocarcinoma cell line HSG
    S Kyakumoto
    Department of Biochemistry, Iwate Medical University School of Dentistry, Chuodori, Morioka, Iwate, Japan
    Endocr Res 29:277-89. 2003
    ..interacts with a coactivator complex composed of various transcription cofactors such as CREB-binding protein (CBP)/p300 and p160 family member proteins represented by steroid receptor coactivator-1 (SRC-1)/NCoA1 and p300/CBP ..
  44. doi Characterization of the complement inhibitory function of rhesus rhadinovirus complement control protein (RCP)
    Marcin Okroj
    Department of Laboratory Medicine, Lund University, University Hospital Malmo, Malmo S 20502, Sweden
    J Biol Chem 284:505-14. 2009
    ..follows: Kaposi sarcoma-associated herpesvirus-complement control protein (KCP) and RRV-complement control protein (RCP). Previously we characterized in detail the functional properties of KCP as a complement inhibitor...
  45. ncbi The relevance and recognition of Latin American science. Introduction to the fourth issue of CBP-Latin America
    Marcelo Hermes-Lima
    Oxyradical Research Group, Departamento de Biologia Celular, Universidade de Brasilia, Brasilia, DF, 70910 900, Brazil
    Comp Biochem Physiol C Toxicol Pharmacol 146:1-9. 2007
    ..is to verify which of these interpretations best applies for the field of comparative biochemistry and physiology (CBP)...
  46. pmc Identification of Legionella pneumophila rcp, a pagP-like gene that confers resistance to cationic antimicrobial peptides and promotes intracellular infection
    M Robey
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Infect Immun 69:4276-86. 2001
    ..resistance to different structural classes of CAMPs compared to the wild type; hence, this gene was designated rcp for resistance to cationic antimicrobial peptides...
  47. ncbi Respiratory compensation point during incremental exercise as related to hypoxic ventilatory chemosensitivity and lactate increase in man
    N Takano
    Physiology Laboratory, Department of School Health, Faculty of Education, Kanazawa University, Kanazawa, 920 1192 Japan
    Jpn J Physiol 50:449-55. 2000
    ..lower VO2, termed the ventilatory threshold (VT); and another at a higher VO2, the respiratory compensation point (RCP)...
  48. doi Minilaparotomy radical cystoprostatectomy (Minilap RCP) in the surgical management of urinary bladder carcinoma: early experience
    Sudhir Rawal
    Department of Uro Oncology, Rajiv Gandhi Cancer Institute and Research Center, Rohini, New Delhi 110085, India
    Jpn J Clin Oncol 38:611-6. 2008
    To assess the feasibility of minilaparotomy for radical cystoprostatectomy (RCP) and urinary diversion in the management of urinary bladder carcinoma.
  49. ncbi Inactivation of mRNA cap-binding protein complex in Drosophila melanogaster embryos under heat shock
    J M Zapata
    Centro de Biologia Molecular, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Biol Chem 266:16007-14. 1991
    We have studied the role of Drosophila 35-kDa cap-binding protein (CBP) and CBP complex in the mechanism of messenger RNA discrimination established in heat-shocked Drosophila embryos...
  50. ncbi Regulation of the human P450scc gene by steroidogenic factor 1 is mediated by CBP/p300
    D Monte
    Laboratory of Molecular Endocrinology, CHUL Research Centre and Laval University, Sainte Foy, Quebec, G1V 4G2, Canada
    J Biol Chem 273:4585-91. 1998
    ..reporter constructs which responded to SF-1 were further stimulated by exogenous p300 and CREB-binding protein (CBP), suggesting interaction between SF-1 and p300/CBP...
  51. ncbi [Cysteamine attenuates suppression of peripheral IL-2 and lymphocytic proliferation induced by ruminal and duodenal operations in goats]
    Zan Ming Shen
    College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
    Shi Yan Sheng Wu Xue Bao 37:501-6. 2004
    ..pre-Op), which contained 3 d of roughage-fed period (RP) and 10 d of roughage + concentrate-fed period (RCP), followed by first operation (Op-1) and then the second operation (Op-2)...
  52. pmc HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner
    Jakob Haettig
    Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California 92697 3800, USA
    Learn Mem 18:71-9. 2011
    ..enzymes, such as the histone acetyltransferase (HAT) CREB (cyclic-AMP response element binding) binding protein (CBP), are pivotal for the transcriptional regulation required for long-term memory...
  53. ncbi Exposure to cadmium and conventional and ambulatory blood pressures in a prospective population study. Public Health and Environmental Exposure to Cadmium Study Group
    J A Staessen
    Hypertensie en Cardiovasculaire Revalidatie Eenheid, Departement voor Cardiovasculair en Moleculair Onderzoek, Katholieke Universiteit Leuven, Belgium
    Am J Hypertens 13:146-56. 2000
    ..follow-up (1991 to 1995; re-examination rate, 81%), blood pressure was measured by conventional sphygmomanometry (CBP; 15 readings in total) and, at follow-up, also by 24-h ambulatory blood pressure monitoring (ABP)...
  54. ncbi The calcium binding proteins calbindin, parvalbumin, and calretinin have specific patterns of expression in the gray matter of cat spinal cord
    Roberta Anelli
    Department of Physiology, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA
    J Neurocytol 34:369-85. 2005
    ..However, knowledge on the cellular regulation governing such cell-specific CBP expression is still incomplete...
  55. pmc Distinct embryonic expression and localization of CBP and p300 histone acetyltransferases at the mouse alphaA-crystallin locus in lens
    Ying Yang
    Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY10461, USA
    J Mol Biol 369:917-26. 2007
    ..Here, we identified CREB-binding protein (CBP) and p300 as major histone acetyltransferases (HATs) associated in vivo with the mouse alphaA-crystallin locus...
  56. doi Anti-inflammatory and antimicrobial effects of garlic and synergistic effect between garlic and ciprofloxacin in a chronic bacterial prostatitis rat model
    Dong Wan Sohn
    Department of Urology, College of Medicine, The Catholic University of Korea, St Mary s Hospital, 62 Youido dong, Youngdungpoku, Seoul 150 713, South Korea
    Int J Antimicrob Agents 34:215-9. 2009
    Chronic bacterial prostatitis (CBP), which is characterised by recurrent urinary tract infection (UTI) and persistence of pathogenic bacteria and evidence of inflammation in the prostatic secretions, is one of the most common causes of ..
  57. pmc Spatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus
    Olivier Bousiges
    INSERM, U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, Strasbourg, France
    Neuropsychopharmacology 35:2521-37. 2010
    Numerous genetic studies have shown that the CREB-binding protein (CBP) is an essential component of long-term memory formation, through its histone acetyltransferase (HAT) function...
  58. pmc Complementation analysis and regulation of CO2 fixation gene expression in a ribulose 1,5-bisphosphate carboxylase-oxygenase deletion strain of Rhodospirillum rubrum
    D L Falcone
    Department of Microbiology, Ohio State University, Columbus 43210 1192
    J Bacteriol 175:5066-77. 1993
    ..rubrum DNA fragments that contain the gene encoding RubisCO, cbbM. When the R. rubrum cbbM deletion strain harbored plasmids containing R. rubrum DNA inserts with at least 2...
  59. ncbi Variation in microdeletions of the cyclic AMP-responsive element-binding protein gene at chromosome band 16p13.3 in the Rubinstein-Taybi syndrome
    R I Blough
    Children s Hospital Research Foundation, Division of Human Genetics, Cincinnati, OH 45229 1933, USA
    Am J Med Genet 90:29-34. 2000
    Most reported microdeletions of the CREB-binding protein (CBP) gene in the Rubinstein-Taybi syndrome (RTS) were detected by fluorescence in situ hybridization (FISH) with a single cosmid probe specific to the 3' region of the gene...
  60. ncbi [Comparison and reproducibility of 4 methods of indirect blood pressure measurement in moderate hypertension]
    T Denolle
    Cabinet de Cardiologie, Dinard
    Arch Mal Coeur Vaiss 88:1165-70. 1995
    ..repeated automatic BP measurements during the 20 minutes preceding the physician examination (RABP) and clinic BP (CBP) with a standard sphygmomanometer mercury column...
  61. doi Cooperative binding of two acetylation marks on a histone tail by a single bromodomain
    Jeanne Moriniere
    European Molecular Biology Laboratory, Grenoble Outstation, 6 rue Jules Horowitz, BP 181, 38042 Grenoble Cedex 9, France
    Nature 461:664-8. 2009
    ..proteins may be capable of a similar mode of ligand recognition, including yeast Bdf1, human TAF1 and human CBP/p300 (also known as CREBBP and EP300, respectively)...
  62. pmc Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling
    V Doucas
    Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 96:2627-32. 1999
    ..Here, we demonstrate that the cAMP enhancer binding protein (CREB)-binding protein (CBP) associates with PML in vitro and is recruited to the PODs in vivo...
  63. ncbi Acetylation regulates transcription factor activity at multiple levels
    E Soutoglou
    Institute of Molecular Biology and Biotechnology Foundation for Research and Technology Hellas, Herakleion Crete, Greece
    Mol Cell 5:745-51. 2000
    CREB-binding protein (CBP) possesses an intrinsic acetyltransferase activity capable of acetylating nucleosomal histones as well as several nonhistone proteins...
  64. pmc Physical association between the histone acetyl transferase CBP and a histone methyl transferase
    L Vandel
    Laboratoire de Biologie Moleculaire Eucaryote, Institut de Biologie Cellulaire et Genetique, Toulouse, France
    EMBO Rep 2:21-6. 2001
    b>CBP (CREB-binding protein) is involved in transcriptional activation by a great variety of sequence-specific transcription factors. CBP has been shown to activate transcription through its histone acetyl transferase activity...
  65. ncbi The role of operant conditioning in chronic pain: an experimental investigation
    Herta Flor
    Department of Neuropsychology, Ruprecht Karls University of Heidelberg, Central Institute of Mental Health, J 5, D 68159 Mannheim, Germany
    Pain 95:111-8. 2002
    ..conditioning for the development and maintenance of chronic pain was examined in 30 chronic back pain patients (CBP) and 30 matched healthy controls...
  66. ncbi Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator-activated receptor gamma
    Nobuyuki Takahashi
    Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    J Biol Chem 277:16906-12. 2002
    The cAMP-response element-binding protein-binding protein (CBP) and p300 are common coactivators for several transcriptional factors...
  67. ncbi The international atom: evolution of radiation control programs
    F J Bradley
    Health Phys 83:121-34. 2002
    ..pool reactor in 1962 that initiated a health physics program for the reactor and a Radiation Control Program (RCP) for the country's use of ionizing radiation...
  68. ncbi Blood lactate changes during isocapnic buffering in sprinters and long distance runners
    Kohji Hirakoba
    Department of Human Sciences, Kyushu Institute of Technology
    J Physiol Anthropol Appl Human Sci 21:143-9. 2002
    ..between [lactate] at lactate threshold (LT) and [lactate] at the onset of respiratory compensation phase (RCP) and the peak value of [lactate] obtained during a recovery period from the end of the exercise test, the relative ..
  69. pmc MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function
    Chi Wai So
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Mol Cell Biol 22:6542-52. 2002
    ..MLL-AFX interacts with the transcriptional coactivator CBP, which is also a fusion partner for MLL in human leukemias...
  70. ncbi Recovery of novel bacterial diversity from a forested wetland impacted by reject coal
    Jennifer E Brofft
    Department of Microbiology, University of Georgia, Athens, GA 30602 2605, USA
    Environ Microbiol 4:764-9. 2002
    ..The Savannah River Site's D-area harbours a 22-year-old exposed reject coal pile (RCP) from which acidic, metal rich, saline runoff has impacted an adjacent forested wetland...
  71. ncbi Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2
    Jose Braganca
    Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, Henry Wellcome Building of Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    J Biol Chem 278:16021-9. 2003
    The transcriptional co-activators and histone acetyltransferases p300/CREB-binding protein (CBP) interact with CITED2, a transcription factor AP-2 (TFAP2) co-activator...
  72. ncbi Polyoma enhancer activator 3, an ets transcription factor, mediates the induction of cyclooxygenase-2 by nitric oxide in colorectal cancer cells
    Yongmin Liu
    Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 279:18694-700. 2004
    ..Taken together, our results demonstrated that NO through beta-catenin signaling stimulated PEA3 to increase COX-2 activity. In addition, NO augmented the synergistic interaction between PEA3 and CBP/p300.
  73. ncbi Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro
    Alessio Zippo
    Dipartimento di Biologia Molecolare, Universita degli Studi di Siena, Via Fiorentina 1, 53100 Siena, Italy
    Blood 103:4536-44. 2004
    ..Further analysis of a number of these genes (Nm23-M1, Nm23-M2, Slug, Set, pp32, Cbp, Ship-1, Btk, and Pim-1) showed that their products were transiently up-regulated in vivo in endothelial cells (ECs)..
  74. ncbi Synergistic activation of CREB-mediated transcription by forskolin and phorbol ester requires PKC and depends on the glutamine-rich Q2 transactivation domain
    Mona Johannessen
    Department of Biochemistry, Institute of Medical Biology, University of Tromsø, Tromsø N 9037, Norway
    Cell Signal 16:1187-99. 2004
    ..domain of cAMP response element-binding protein (CREB) allows basal transcriptional activity, while recruitment of CBP/p300 through signal-induced phosphorylation of the kinase-inducible domain at serine-133 enhances CREB-dependent ..
  75. pmc Sequential histone modifications at Hoxd4 regulatory regions distinguish anterior from posterior embryonic compartments
    Mojgan Rastegar
    McGill Cancer Centre, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Biol 24:8090-103. 2004
    ..Neither RNA polymerase II (Pol II) nor CBP associated with the inactive gene...
  76. pmc A genetic screen identifies putative targets and binding partners of CREB-binding protein in the developing Drosophila eye
    Jason Anderson
    Department of Biology, Indiana University, 1001 E 3rd Street, Jordan Hall A318, Bloomington, IN 47401, USA
    Genetics 171:1655-72. 2005
    Drosophila CREB-binding protein (dCBP) is a very large multidomain protein, which belongs to the CBP/p300 family of proteins that were first identified by their ability to bind the CREB transcription factor and the adenoviral protein E1...
  77. pmc Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation
    Nagalakshmi Nadiminty
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Proc Natl Acad Sci U S A 103:7264-9. 2006
    ..of Stat3 by the acetyltransferase activity of cAMP-response element-binding protein (CREB)-binding protein (CBP)/p300...
  78. pmc Mediator modulates Gli3-dependent Sonic hedgehog signaling
    Haiying Zhou
    Department of Molecular Medicine, Institute of Biotechnology, The University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245 3207, USA
    Mol Cell Biol 26:8667-82. 2006
    ..whose activity derives from concerted functional interactions with both Mediator and the histone acetyltransferase CBP. Analysis of MBD truncation mutants revealed an excellent correlation between the in vivo activation strength of an ..
  79. ncbi [Substance use and risk behaviors of out-of-treatment cocaine base paste and cocaine hydrochloride users]
    Rodrigo Santis B
    Departamento de Psiquiatria, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Rev Med Chil 135:45-53. 2007
    In Chile, cocaine base paste (CBP) is the illegal substance that produces the highest rate of addiction. Nonetheless, a marginal number of users receive treatment each year.
  80. pmc Regulation of acetylation at the major histocompatibility complex class II proximal promoter by the 19S proteasomal ATPase Sug1
    Olivia I Koues
    Division of Molecular Genetics and Biochemistry, Department of Biology, Georgia State University, Atlanta, Georgia 30302, USA
    Mol Cell Biol 28:5837-50. 2008
    ..Sug1 also binds to the MHC-II histone acetyltransferase CREB-binding protein (CBP) and is critical for the recruitment of CBP to the MHC-II proximal promoter...
  81. pmc The transcriptional cofactor MIER1-beta negatively regulates histone acetyltransferase activity of the CREB-binding protein
    Tina M Blackmore
    Terry Fox Cancer Research Laboratories, Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, A1B 3V6, Canada
    BMC Res Notes 1:68. 2008
    ..To further explore the role of MIER1 in chromatin remodeling, we investigated the functional interaction of MIER1 with the histone acetyltransferase (HAT), Creb-binding protein (CBP).
  82. pmc Respiratory syncytial virus impairs macrophage IFN-alpha/beta- and IFN-gamma-stimulated transcription by distinct mechanisms
    Albert P Senft
    Infectious Diseases Program, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108, USA
    Am J Respir Cell Mol Biol 42:404-14. 2010
    ..stimulation resulted from a reduction in the nuclear STAT1 interaction with the transcriptional coactivator, CBP, and was correlated with increased phosphorylation of STAT1beta, a dominant-negative STAT1 splice variant, in ..
  83. pmc Alternative memory in the CD8 T cell lineage
    You Jeong Lee
    The Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN, USA
    Trends Immunol 32:50-6. 2011
    ..of innate CD8+ T cells develops in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3. These cells have the phenotype and function of memory CD8+ T cells, without previous exposure to antigen...
  84. pmc Hepatitis C virus NS3 protein can activate the Notch-signaling pathway through binding to a transcription factor, SRCAP
    Atsushi Iwai
    Department of Bioresources, Hokkaido University Research Center for Zoonosis Control, Sapporo, Hokkaido, Japan
    PLoS ONE 6:e20718. 2011
    ..We identified SRCAP (Snf2-related CBP activator protein) as a NS3 binding protein using yeast two-hybrid screening, and a co-immunoprecipitation assay ..
  85. doi Exercise ventilatory kinematics in endurance trained and untrained men and women
    Aimee M Layton
    Department of Biobehavioral Sciences, Teachers College, Columbia University, 525 120th St, New York, NY 10027, USA
    Respir Physiol Neurobiol 178:223-9. 2011
    ..Female ET did not change chest wall end-expiratory volume (V(CW,ee)) or pulmonary ribcage (V(RCp,ee)) with exercise, while female UT significantly decreased V(CW,ee) and V(RCp,ee) with exercise (p<0.05)...
  86. pmc Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control
    David C Bedford
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Metab 14:219-30. 2011
    ..Mice heterozygous for the acetyltransferase CREB binding protein (CBP) are lean and insulin sensitized, but how CBP regulates energy homeostasis is unclear...
  87. doi p300 mediates cellular resistance to doxorubicin in bladder cancer
    Ario Takeuchi
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Mol Med Rep 5:173-6. 2012
    ..Previously, we reported that the histone acetyltransferase p300/CBP-associated factor is involved in doxorubicin resistance in bladder cancer...
  88. pmc Making sense out of antisense transcription in human T-cell lymphotropic viruses (HTLVs)
    Benoit Barbeau
    Departement des Sciences Biologiques, Centre de recherche Bio Med, Universite du Quebec a Montreal, Montréal H2X3X8, Quebec, Canada
    Viruses 3:456-68. 2011
    ..transcription factor cAMP-response element-binding protein (CREB) and the pleiotropic cellular coactivators p300/CBP. HBZ can also activate cellular transcription through its interaction with p300/CBP...
  89. doi Microbial CO2 fixation potential in a tar-oil-contaminated porous aquifer
    Claudia Kellermann
    Institute of Groundwater Ecology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, GmbH, Neuherberg, Germany
    FEMS Microbiol Ecol 81:172-87. 2012
    ..communities of a petroleum hydrocarbon-contaminated aquifer by detection of functional marker genes (cbbL, cbbM), encoding different forms of the key enzyme RubisCO of the Calvin-Benson-Bassham cycle...
  90. pmc An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation
    Matthew B Potts
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell Stem Cell 11:5-6. 2012
    ..In this issue of Cell Stem Cell, Wang et al. (2012) demonstrate that the diabetes medication metformin enhances spatial learning in mice by activating the atypical PKC/CBP pathway in adult neural stem cells.
  91. doi Suppression of tumor growth by designed dimeric epidithiodiketopiperazine targeting hypoxia-inducible transcription factor complex
    Ramin Dubey
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, 1985 Zonal Ave, PSC B15C, HSC 9121, Los Angeles, California 90089, USA
    J Am Chem Soc 135:4537-49. 2013
    ..antagonist, dimeric epidithiodiketopiperazine (ETP 2), selectively disrupts the interaction of HIF1α with p300/CBP coactivators and downregulates the expression of hypoxia-inducible genes...
  92. doi PCAF acetylates Runx2 and promotes osteoblast differentiation
    Chao yang Wang
    Department of Orthopaedics, 98 Hospital of PLA, Zhejiang, 313000, Huzhou, China
    J Bone Miner Metab 31:381-9. 2013
    ..Here we reported that p300/CBP-associated factor (PCAF) directly binds to Runx2 and acetylates Runx2, leading to an increase in its ..
  93. pmc Role for compartmentalization in nephron progenitor differentiation
    Aaron C Brown
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Proc Natl Acad Sci U S A 110:4640-5. 2013
    ..an integral role for bone morphogenetic protein-SMAD in promoting transition of progenitors from the primitive Cbp/p300-interacting transactivator 1 expressing (CITED1+) compartment to the uniquely sine oculis-related homeobox 2 ..
  94. doi The evolving role of antifungal susceptibility testing
    Gregory A Eschenauer
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Pharmacotherapy 33:465-75. 2013
    ..current clinical utility of AST and the clinical data support utilized in the development of clinical breakpoints (CBP) for common pathogens causing invasive fungal infections...
  95. pmc Urine and serum microRNA-1 as novel biomarkers for myocardial injury in open-heart surgeries with cardiopulmonary bypass
    Xian Zhou
    Department of Internal Medicine and Anesthesiology and Critical Care Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan Province, China
    PLoS ONE 8:e62245. 2013
    ..miR-1 levels in 20 patients with elective mitral valve surgery were measured at pre-surgery, pre-CPB, 60 min post-CBP, and 24h post-CBP. Serum cardiac troponin-I (cTnI) was used as a positive control biomarker for cardiac injury...
  96. doi Respiratory compensation point during incremental test in overweight and normoweight boys: is it useful in assessing aerobic performance? A longitudinal study
    Marcin Maciejczyk
    Institute of Biomedical Sciences, University School of Physical Education in Kraków, Krakow, Poland
    Clin Physiol Funct Imaging 34:56-63. 2014
    The purpose of this study was to investigate the characteristics of the respiratory compensation point (RCP) in overweight and normoweight boys and to clarify changes in the RCP over 4 years...
  97. pmc Molecular mechanisms underlying activity-dependent AMPA receptor cycling in retinal ganglion cells
    Tanya M Casimiro
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, The Rose F Kennedy Center, 1410 Pelham Parkway, Bronx, NY 10461, United States
    Mol Cell Neurosci 56:384-92. 2013
    ..The synaptic CBP input onto On RGCs is mediated by AMPA-type glutamate receptors (AMPARs) that include both those lacking a GluA2 ..
  98. pmc Effects of eye movement desensitization and reprocessing (EMDR) on non-specific chronic back pain: a randomized controlled trial with additional exploration of the underlying mechanisms
    Jonas Tesarz
    Department of Internal Medicine and Psychosomatics, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg D 69120, Germany
    BMC Musculoskelet Disord 14:256. 2013
    Non-specific chronic back pain (CBP) is often accompanied by psychological trauma, but treatment for this associated condition is often insufficient...
  99. doi Epigenetic modulation of adult hippocampal neurogenesis by extremely low-frequency electromagnetic fields
    Lucia Leone
    Institute of Human Physiology, Medical School, Universita Cattolica, Largo Francesco Vito 1, 00168, Rome, Italy
    Mol Neurobiol 49:1472-86. 2014
    ..by the Cav1-channel blocker nifedipine, and were associated with increased occupancy of CREB-binding protein (CBP) to the same loci within the analyzed promoters...
  100. pmc β-catenin activation in a novel liver progenitor cell type is sufficient to cause hepatocellular carcinoma and hepatoblastoma
    Sharada Mokkapati
    Department of Genetics, University of Texas MD Anderson Cancer Center Graduate Program in
    Cancer Res 74:4515-25. 2014
    ..and GFP are controlled by a 190-kb 5' genomic region of Cited1, a transcriptional coactivator protein for CBP/p300...
  101. pmc Safely targeting cancer stem cells via selective catenin coactivator antagonism
    Heinz Josef Lenz
    USC Norris Comprehensive Cancer Center, USC Center for Molecular Pathways and Drug Discovery, University of Southern California, Los Angeles, California, USA
    Cancer Sci 105:1087-92. 2014
    ..This review will discuss the discovery of the specific CBP/catenin antagonist ICG-001 and the ongoing clinical development of the second generation CBP/catenin antagonist PRI-..

Research Grants72

  1. RAJESH K ANEJA; Fiscal Year: 2016
    ..HAT) activity of p300 and a closely related protein, cAMP response element-binding protein (CREB)-binding protein (CBP);3) PARP-1 inhibits LPS-mediated HMGB1 gene transcription...
  2. Role of histone acetyltransferases in memory storage and synaptic plasticity
    MARCEL ANDRE ESTEVEZ; Fiscal Year: 2012
    ..factors like CREB, but also transcriptional coactivators, such as the paralogous factors CREB- binding protein (CBP) and p300...
  3. Role of Cited2 in Hematopoiesis
    Yu Chung Yang; Fiscal Year: 2011
    Cited2 [CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2] is one of the founding members of a new family of transcriptional modulators...
  4. Histone Acetylation and Insulin Gene Expression
    Sabire Ozcan; Fiscal Year: 2010
    ..of Pdx-1 important for Pdx-1 activity and/or DNA binding? 2) What role do the histone acetyltransferases p300/CBP and GCN5/PCAF play in glucose regulation of insulin gene expression? 3) Do the beta-cell specific transcription ..
  5. Acetylation-Dependent IFN Signal Transduction
    Y Eugene Chin; Fiscal Year: 2010
    ..We detected IFNR2 acetylation by recruiting tumor suppressor-like transcription cofactor CREB-binding protein (CBP) or its homologous p300. Acetylated IFNR2 can then recruit IRF9...
  6. Coregulatory factor modulation of CREB activity
    ROLAND P KWOK; Fiscal Year: 2010
    ..Our preliminary data show that CBP, the co-activator of the CRE-binding protein CREB, forms a complex with co-repressor histone deacetylases (HDAC)...
  7. Zhonghui Guan; Fiscal Year: 2016
    ..As members of the ATF family bind the KIX domain of CBP, which acetylates histones at gene promoters and regulates gene transcription, we tested the hypothesis that CBP ..
  8. John S Davis; Fiscal Year: 2014
    ..To determine whether 2-catenin interaction with LRH-1 recruits additional transcriptional co-activators, such as CBP (CREB-binding protein), during the regulation of StAR expression and progesterone synthesis...
  9. Chemical Modulators for p53 Functions in Transcriptional Regulation
    SYED S MUJTABA; Fiscal Year: 2012
    ..Our study revealed that p53 recruitment of the co-activator CBP (CREB binding protein) requires association of the conserved bromodomain of CBP (CBP BRD) with p53 at acetylated ..
  10. CBP Bromodomain Antagonists Block Androgen Receptor in Prostate Cancer
    SYED S MUJTABA; Fiscal Year: 2010
    ..Resultantly, AR remains a valuable therapeutic target due to this organ specificity. Although it is known that CBP/p300 (CREB binding protein) mediated lysine acetylation of AR (ARKac) plays a vital role in AR activation and ..
  11. Beta-cell Proliferation
    Fredric E Wondisford; Fiscal Year: 2013
    ..Phosphorylated CREB recruits the nuclear co-activators CREB binding protein (CBP), and the related protein p300, which stimulate gene transcription through histone deacetylase activity and ..
  12. Subbiah Pugazhenthi; Fiscal Year: 2016
    ..c-jun, STAT-1 and NF-?B, the transcriptions factors that compete with CREB for the limited pool of coactivators, CBP and p300. (iii) Inflammation can direct CREB to pathways other than those needed for neuronal function...
  13. Mechanisms of p53 activation in tumorsuppression
    Wei Gu; Fiscal Year: 2012
    ..In our early studies, we found that histone acetyltransferase CBP/p300 promotes p53-dependent transcription by directly acetylating lysine residues in the C-terminal region of p53...
  14. Regulation of transcription by chromatin modifying enzymes in extinction learning
    Ruth M Barrett; Fiscal Year: 2010
    ..The first aim of this research proposal is to determine the role of CREB-binding protein (CBP), a histone acetyltransferase known to be involved in associative learning, in the acquisition of extinction...
  15. Peilin Li; Fiscal Year: 2014
    ..IRF-1 also can interact with HAT, such as p300/CBP (cAMP-responsive-element-binding factor (CREB)-binding protein) to evoke HIV transcription from the LTR in the ..
  16. Ronen Marmorstein; Fiscal Year: 2016
    ..HATs fall into at least four families based on sequence conservation, Gcn5/PCAF, MYST, p300/CBP and Rtt109...
  17. Gerhard Wagner; Fiscal Year: 2016
    ..by SREBPs, demonstrating a central role for the MED15 subunit of the Mediator co-activator complex and the CBP/p300 acetyltransferases...
  18. Protective role of creb-binding protein in maturation and aging
    Charles V Mobbs; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): We propose the rapid decline of CBP and associated histone acetyltransferase (HAT) activity during maturation serves the function of ending a series of critical periods of organization, especially in ..
  19. Chromatin Remodeling and Memory Storage
    MARCELO ANDRES WOOD; Fiscal Year: 2012
    ..For example, our previous research demonstrated that CREB-binding protein (CBP), a potent HAT and transcriptional coactivator, is critical for long-lasting forms of synaptic plasticity (the ..
  20. Epigenetic Regulation of Hippocampal Synaptic Plasticity
    MORGAN STUART BRIDI; Fiscal Year: 2013
    ..acetylation by the cyclic AMP response element binding protein (CREB) and the co-activator CREB-binding protein (CBP), are also strong candidates for negative regulation by the Sin3a/HDAC complex...
  21. In vivo Analysis of ATM-Regulated Pathways
    RANDAL SCOT TIBBETTS; Fiscal Year: 2011
    ..of CREB by ATM and CK1/CK2 inhibits the interaction between CREB and its coactivator, CREB-binding protein (CBP) suggesting that the ATM pathway may repress CREB transcriptional functions in response to DNA damage...
  22. ESE 1 a novel transcriptional regulator of cartilage remodeling
    MARY GOLDRING; Fiscal Year: 2009
    ..type II collagen gene (COL2A1) expression by binding to the COL2A1 promoter and by interacting with Sox9 and CBP. Our preliminary data show that ESE-1 also increases matrix metalloproteinase (MMP)-13, a key collagen-degrading ..
  23. Transcriptional Regulation by the HTLV-1 Tax Protein
    Jennifer K Nyborg; Fiscal Year: 2013
    ..Together, this complex recruits the cellular coactivators CBP/p300, which is a fundamental step in transcriptional activation of HTLV-1...
  24. Gourisankar Ghosh; Fiscal Year: 2016
    ..In aim 1 experiments are designed to investigate the mechanisms of transcriptional control by the RelA:CBP/p300 complex...
  25. Wen Wei Tsai; Fiscal Year: 2014
    ..In specific aim 1, the role of PRMT5 in methylating CREB and modulating the interaction between CREB and CRTC2 or CBP will be explored. CREB arginine residues that undergo methylation will be identified...
  26. Activities of HHV-8 vIRF-1 in Virus Biology
    John Nicholas; Fiscal Year: 2012
    ..Cellular proteins targeted for inhibition by vIRF-1 include p53, ATM, GRIM19, Smad transcription factors, and p300/CBP transcriptional co-activators required for IRF-?mediated responses...
  27. Michael Kahn; Fiscal Year: 2016
    ..interactions between b-catenin and either of its transcriptional coactivators, p300 or CREB binding protein (CBP), have led us to propose a model to explain dichotomous activities of Wnt/[unreadable]-catenin signaling, in which ..
  28. Folding Mechanism of Intrinsically Disordered Proteins: The pKID/KIX complex
    ROBERT CULIK; Fiscal Year: 2013
    ..complex, which are two domains isolated from the transcription factor CREB and its activator CREB binding protein (CBP)...
  29. Regulation of NFkappaB activity by the Estrogen Receptor
    Kendall W Nettles; Fiscal Year: 2012
    ..This hypothesis will be pursued in the following Specific Aims: SPECIFIC AIM 1. To investigate the importance of CBP and Grip1 in the molecular interactions required for ER-mediated suppression of NF-B, we will measure their ..
  30. Effect of chromatin remodelers/modifiers on HIV-1 Tat activated transcription
    Fatah Kashanchi; Fiscal Year: 2010
    ..in HIV-1 infected cells by binding the trans-activation response region (TAR) and recruiting cdk9/cyclin T1, p300/CBP, SWI/SNF, and RNA Polymerase II. Sustained HIV-1 replication further progresses infected T cells towards AIDS...
  31. Charles G Mullighan; Fiscal Year: 2016
    ..identified lesions in the two genes encoding the KAT3 family of histone acetyltransferases, CREB-binding protein (CBP, CREBBP) and EP300 (p300). ALL is the most common childhood cancer and the focus of this proposal...
  32. Wei Gu; Fiscal Year: 2016
    ..In our early studies, we found that CBP/p300 promotes p53-dependent transcription by directly acetylating lysine residues in the C-terminal region of p53 (..
  33. Marshall B Elam; Fiscal Year: 2014
    ..i) n-3 PUFA modulate the interaction of LXR1 with transcription factors (Sp1, SREBP- 1c), co-activators (SRC-1, CBP), and co-repressors (NcoR, SMRT, HDAC), (ii) n-3 PUFA alter binding and/or metabolism of endogenous ligands of LXR1 ..
  34. Transcription Programming in Cardiac Growth
    NANETTE HAHR BISHOPRIC; Fiscal Year: 2012
    ..We will carry out cardiac-specific deletion of p300 and CBP to determine whether these proteins have distinct or myocyte-autonomous roles in hypertrophy...
  35. Genome-wide protein-DNA interactions responding to chronic opioid treatment
    Yulong Chen; Fiscal Year: 2012
    ..We will establish this method to analyze genome-wide CBP/p300-NF-:B/p65-DNA interactions in mu and delta opioid receptor-expressing cells after acute and chronic morphine (..
  36. Opposing and complementary roles of KLF1 and KLF2 in erythropoiesis
    Joyce A Lloyd; Fiscal Year: 2012
    ..and knockout (KO) mouse models will be used to determine if KLF1 and KLF2 are required for recruitment of BRG1 and CBP/p300 chromatin remodeling complexes to the [unreadable]-globin LCR and promoters...
  37. Mary B Goldring; Fiscal Year: 2014
    ..type II collagen gene (COL2A1) expression by binding to the COL2A1 promoter and interacting with Sox9 and CBP and that ESE-1 immunostaining is increased in superficial and midzone regions of cartilage from patients with ..
  38. ISABELLE MICHELE LEMASSON; Fiscal Year: 2014
    ..We found that HBZ also binds directly to the cellular coactivators p300 and CBP, which is mediated through regions of the viral protein outside its bZIP domain...
  39. KLF2 as a novel regular for monocyte activation and function
    Hiranmoy Das; Fiscal Year: 2012
    ..activity of both NF-kB and activator protein-1 in part by means of recruitment of transcriptional coactivator p300/CBP-associated factor, PCAF. These observations implicate KLF2 as a novel negative regulator of monocytic activation...
  40. Functions of an E1A-Associated Cellular Protein
    Bayar Thimmapaya; Fiscal Year: 2010
    ..These include p400, p300 and the highly related CBP, Retinoblastoma protein (Rb), and two Rb related proteins p107 and p130...
  41. Long-range function of the ERV-9 LTR in regulating globin gene switching
    DOROTHY Y TUAN; Fiscal Year: 2012
    ..We subsequently found that in the [unreadable]LTR Tg mice, LTR deletion lowered the levels of NF-Y, GATA-2 and CBP on the [unreadable]-globin promoter but increased the levels of these factors on the [unreadable]-globin promoter ..
  42. Human autism genetics and activity dependent gene activation
    Christopher A Walsh; Fiscal Year: 2010
    ..g. MEF2, c-fos, SR, CREB, CBP, etc...
  43. Edward E Morrisey; Fiscal Year: 2015
    ..Hdac function is counterbalanced by acetylatransferases including p300 and CBP. We have begun to explore the importance of Hdac mediated chromatin remodeling complexes by inactivating Hdac1 and ..
  44. E1A Oncoprotein Induced Deregulation of Replication Origin Firing
    Bayar Thimmapaya; Fiscal Year: 2012
    ..In cooperation with cellular activated ras or virus encoded E1B19K or 55K proteins and by binding to p300/CBP and Rb family proteins, E1A can transform rodent cells...
  45. MARCELO ANDRES WOOD; Fiscal Year: 2016
    ..Specific Aim 3, we will examine the effects of inhibiting a chromatin modifying enzyme called CREB-binding protein (CBP), which relaxes chromatin structure, through genetic mutations and focal deletions of CBP, thereby inhibiting ..
  46. Roles of Zinc Transporter ZIP4 (SLC39A4) in Pancreatic Cancer Pathogenesis
    Min Li; Fiscal Year: 2010
    ..We will also determine whether overexpression of ZIP4 a) upregulates the transcription of IL-6 through CBP/CREB transcription factors, and b) affects PC cell proliferation and tumor progression via the IL-6/STAT3 pathway...
  47. ANDREW JESS DANNENBERG; Fiscal Year: 2015
    ..PGE2, BRCA1, histone acetylation and aromatase induction, based on our novel data implicating BRCA1, Sirt-1 and CBP/p300 in PGE2-mediated aromatase induction...
  48. Activator-Targeted Subunits of the ARC/Mediator
    Anders M Naar; Fiscal Year: 2010
    ..examine how SREBPs interact molecularly and functionally with the putative ARC105 KIX domain in comparison with the CBP and p300 KIX domains...
  49. Regulation of NF-kappaB transactivation function
    BRIAN ASHBURNER; Fiscal Year: 2009
    ..These coactivators include the CREB-binding protein (CBP) and its homolog, p300;the p300/CBP associated factor (P/CAF);and members of the steroid receptor coactivator (p160/..
  50. The role of PRR7 in gene transcription and synaptic function
    DANA OR SAVARIEGO; Fiscal Year: 2013
    ..syndrome result from mutations in the transcription factor MeCP2 and the transcription co-activator CBP, respectively...
  51. Mitochondrial-localized activities of HHV-8 vIRF-1
    John Nicholas; Fiscal Year: 2013
    ..Cellular proteins targeted for inhibition by vIRF-1 include p53, ATM, GRIM19, Smad transcription factors, and p300/CBP transcriptional co-activators required for IRF-mediated responses...
  52. Cheng Ming Chiang; Fiscal Year: 2016
    ..system that we have developed to define the role of cellular chromatin-modifying enzymes, including p300 and CBP histone acetyltransferases (HATs), in AP-1-dependent activation of HPV chromatin transcription...
  53. Nicola C Partridge; Fiscal Year: 2016
    ..In the nucleus, Runx2 then recruits the histone acetyl transferases (HATs), p300 and p300/CBP associated factor (PCAF)...
  54. Brain epigenetic mechanisms in alcohol dependence
    SUBHASH PANDEY; Fiscal Year: 2009
    ..binding (p-CREB) regulates neuronal plasticity via recruitment of the HAT associated with CREB binding protein (CBP) to activate gene transcription...
  55. REGULATION OF GROWTH FACTORS AND EMBRYOGENESIS
    ARNOLD RIZZINO; Fiscal Year: 2005
    ..its effects? Recent studies argue that Sox-2 and Oct-3 can mediate their effects through the co-activators p300 and CBP (p300/CBP)...
  56. Ming Ming Zhou; Fiscal Year: 2014
    ..Increase in FosB promoter acetylation has been shown to be dependant on CBP (CREB binding protein) dependant histone acetyl transferase (HAT) activity...
  57. MECHANISMS OF PATHOGENESIS BY THE MYB ONCOPROTEIN
    Richard Press; Fiscal Year: 2000
    ..2) by characterizing the recently-discovered binding interaction between myb and the transcriptional co-activator CBP, and 3) by determining the normal and pathologic functional consequences of the myb-CBP binding interaction...
  58. Role of Cited2 in lens development and hyaloid vascular regression
    Yu Chung Yang; Fiscal Year: 2010
    Cited2 (CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2) is a founding member of a new family of transcriptional modulators...
  59. EBNA3C and tumor supressors
    Erle S Robertson; Fiscal Year: 2010
    ..We will investigate the recruitment of acetylases including p300 and CBP by EBNA3C to determine its ability to modify p53 through acetylation and whether or not phosphorylation is critical ..
  60. Xiangshu Xiao; Fiscal Year: 2014
    ..We recently developed a novel assay to specifically look at CREB-CBP interaction and discovered naphthol AS-E as a small molecule inhibitor of CREB-CBP interaction both in vitro and in ..
  61. CITED2 and Mechanical Loads
    Hui Bin Sun; Fiscal Year: 2010
    ..We recently identified a novel transcriptional regulator CITED2 (CBP/p300-lnteracting Transactivator with ED-rich tail 2) that is induced in chondrocytes and other cells by ..
  62. The Distinct Role of CBP and p300 in Regulating Hepatic Glucose Production
    Ling He; Fiscal Year: 2013
    ..have shown that both the anti-diabetic agent metformin and insulin phosphorylate the transcriptional co- activator CBP at serine 436 via PKC[unreadable]/[unreadable], leading to the suppression of hepatic glucose production...
  63. Alisha D Howard; Fiscal Year: 2014
    ..Tax recruits the cellular proteins cAMP-response element binding protein (CREB) and p300/CREB-binding protein (CBP) to viral CRE sites located in the HTLV-1 LTR (for review see [1])...
  64. Role of Cited2 in Lung Development
    Yu Chung Yang; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cited2 [CBP/p300-interacting transactivators with glutamic acid (E) and aspartic acid (D)-rich tail 2] is one of the founding members of a new family of transcriptional activators...
  65. HTS development for targeted anti-fungal small molecules
    Paul D Kaufman; Fiscal Year: 2010
    ..Rtt109 is very distantly related the mammalian p300/CBP HAT enzyme, but compounds that inhibit p300/CBP do not inhibit Rtt109...
  66. CONTROL OF P53 TUMOR SUPPRESSOR BY CBP/P300
    Tso Pang Yao; Fiscal Year: 2005
    DESCRIPTION (from the application): The long-term objective of this proposal is to elucidate the function of CBP and its family member p300 in cellular growth and oncogenesis...
  67. Paradigm and attentional manipulations to improve P300-based BCI
    Eric Sellers; Fiscal Year: 2010
    ..e., the row/column paradigm or the RCP), the CBP presents quasi-random groups of stimuli derived from a checkerboard style layout...
  68. Characterization of Neuroendocrine CGRP Receptors
    Ian Dickerson; Fiscal Year: 2006
    ..We have discovered a 148 aa protein named calcitonin gene-related peptide (CGRP)-receptor component protein (RCP) that is required for G protein-coupled signal transduction at receptors for the neuropeptide CGRP...
  69. SRCAP Regulation of CREB and GR-mediated Transcription
    John Chrivia; Fiscal Year: 2005
    CREB-binding protein (CBP) functions as a coactivator for many transcription factors and is able to respond to extracellular signals to specifically regulate gene expression...
  70. CONTROL OF TRANSLATION BY POLIOVIRUS PROTEINASE
    Richard Lloyd; Fiscal Year: 1999
    ..that poliovirus infection of HeLa cells results in inactivation of an initiation factor, the cap binding protein (CBP) complex, which its believed to facilitate binding of capped mRNAs to ribosomal 40S subunits...
  71. Molecular Functions of the Adenovirus E1A Oncogene
    Maurice Green; Fiscal Year: 2006
    ..A large panel of EIA single amino acid substitution mutants will be used to define interactions among E1A, p300/CBP, and TBP and to establish their relevance to the E1A repression function...
  72. STRUCTURE AND FUNCTION OF SV40 NON-VIRION PROTEINS
    David Livingston; Fiscal Year: 2007
    Abstract: The specific aims of the ongoing work are : 1) to understand how p300 and CBP participate in the operations of hematopoietic stem cells and, as such, to learn how they operate as hematopoeitic tumor suppressing elements; 2) to ..