OGG1

Summary

Gene Symbol: OGG1
Description: 8-oxoguanine DNA glycosylase
Alias: HMMH, HOGG1, MUTM, OGH1, N-glycosylase/DNA lyase, 8-hydroxyguanine DNA glycosylase, AP lyase, DNA-apurinic or apyrimidinic site lyase, OGG1 type 1f
Species: human

Top Publications

  1. ncbi Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA
    S D Bruner
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 403:859-66. 2000
  2. ncbi Polymorphisms of DNA repair genes and risk of non-small cell lung cancer
    Shanbeh Zienolddiny
    Department of Toxicology, National Institute of Occupational Health, Oslo, Norway
    Carcinogenesis 27:560-7. 2006
  3. ncbi Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review
    Rayjean J Hung
    Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 162:925-42. 2005
  4. ncbi Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk
    Kim De Ruyck
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, Proeftuinstraat 86, B 9000 Gent, Belgium
    Mutat Res 631:101-10. 2007
  5. ncbi Expression of 8-oxoguanine DNA glycosylase 1 (OGG1) and the level of p53 and TNF-αlpha proteins in peripheral lymphocytes of patients with Alzheimer's disease
    Mateusz Dezor
    Laboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, Poland
    Folia Neuropathol 49:123-31. 2011
  6. ncbi Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA
    T Kohno
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Oncogene 16:3219-25. 1998
  7. doi Effect of combined genetic polymorphisms on lung cancer risk in northern Thai women
    Jaewwaew Klinchid
    Division of Clinical Chemistry, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand
    Cancer Genet Cytogenet 195:143-9. 2009
  8. pmc Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase
    Jeff W Hill
    Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, USA
    Nucleic Acids Res 34:1620-32. 2006
  9. doi Genetic polymorphism of DNA base-excision repair genes (APE1, OGG1 and XRCC1) and their correlation with risk of lung cancer in a Chinese population
    Zheng Li
    Department of Pathology, Third Military Medical University, Chongqing, China
    Arch Med Res 42:226-34. 2011
  10. pmc Poly(ADP-ribose) polymerase 1 (PARP-1) binds to 8-oxoguanine-DNA glycosylase (OGG1)
    Nicole Noren Hooten
    Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 286:44679-90. 2011

Research Grants

  1. DNA Repair of Endogenous Lesions in Carcinogenesis
    Rabindra Roy; Fiscal Year: 2010
  2. ISTVAN STEVEN BOLDOGH; Fiscal Year: 2014
  3. Repair of Oxidatively Damaged Guanines
    A LIEN L LU-CHANG; Fiscal Year: 2013
  4. SAMY LEWIZ HABIB; Fiscal Year: 2016
  5. Oxidative Stress, Mitochondrial Dysfunction and Aging
    JOHN NMN PAPACONSTANTINOU; Fiscal Year: 2010
  6. Structure and Mechanism in DNA Excision Repair
    GREGORY LAWRENCE VERDINE; Fiscal Year: 2013
  7. Repair of Oxidized Bases in Mammalian Genomes
    Sankar Mitra; Fiscal Year: 2012
  8. Mitochondrial DNA repair agents for acute lung injury
    Mark N Gillespie; Fiscal Year: 2012
  9. David W Kamp; Fiscal Year: 2016
  10. David W Kamp; Fiscal Year: 2016

Detail Information

Publications267 found, 100 shown here

  1. ncbi Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA
    S D Bruner
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 403:859-66. 2000
    ..The dedicated repair pathway for oxoG centres on 8-oxoguanine DNA glycosylase (hOGG1), an enzyme that recognizes oxoG x C base pairs, catalysing expulsion of the oxoG and cleavage of the DNA backbone...
  2. ncbi Polymorphisms of DNA repair genes and risk of non-small cell lung cancer
    Shanbeh Zienolddiny
    Department of Toxicology, National Institute of Occupational Health, Oslo, Norway
    Carcinogenesis 27:560-7. 2006
    ..repair (NER) genes XPA, ERCC1, ERCC2/XPD, ERCC4/XPF and ERCC5/XPG; base excision repair (BER) genes APE1/APEX, OGG1, MPG, XRCC1, PCNA, POLB, POLiota, LIG3 and EXO1; double-strand break repair (DSB-R) genes XRCC2, XRCC3, XRCC9, NBS1 ..
  3. ncbi Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review
    Rayjean J Hung
    Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 162:925-42. 2005
    ..in the base excision repair pathway and cancer risk, focusing on three key genes: 8-oxoguanine DNA glycosylase (OGG1), apurinic/apyrimidinic endonuclease (APE1/APEX1), and x-ray repair cross-complementing group 1 (XRCC1)...
  4. ncbi Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk
    Kim De Ruyck
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, Proeftuinstraat 86, B 9000 Gent, Belgium
    Mutat Res 631:101-10. 2007
    ..nucleotide-excision repair gene polymorphisms (XRCC1 -77 T/C, Arg194Trp, Arg280His and Arg399Gln; APE1 Asp148Glu; OGG1 Ser326Cys; XPA -4 G/A; XPC PAT; XPD Asp312Asn and Lys751Gln) with lung cancer risk in Caucasians...
  5. ncbi Expression of 8-oxoguanine DNA glycosylase 1 (OGG1) and the level of p53 and TNF-αlpha proteins in peripheral lymphocytes of patients with Alzheimer's disease
    Mateusz Dezor
    Laboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, Poland
    Folia Neuropathol 49:123-31. 2011
    The aim of the study was to determine the extent of oxidative DNA damage (levels of 8-oxo2dG) and expression of OGG1 and p53 and TNF-α proteins in lymphocytes of Alzheimer's disease (AD) patients and a control group...
  6. ncbi Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA
    T Kohno
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Oncogene 16:3219-25. 1998
    The hOGG1 gene encodes a DNA glycosylase that excises 8-hydroxyguanine (oh8Gua) from damaged DNA. Structural analyses of the hOGG1 gene and its transcripts were performed in normal and lung cancer cells...
  7. doi Effect of combined genetic polymorphisms on lung cancer risk in northern Thai women
    Jaewwaew Klinchid
    Division of Clinical Chemistry, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand
    Cancer Genet Cytogenet 195:143-9. 2009
    ..Thai population: CYP1A1 (MspI), CYP1A1 (Ile462Val), CYP2E1 (PstI), CYP2E1 (DraI), GSTM1, GSTT1, MPO (AciI), OGG1 (Ser326Cys), TP53 (Arg72Pro), and MMP1(AluI)...
  8. pmc Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase
    Jeff W Hill
    Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, USA
    Nucleic Acids Res 34:1620-32. 2006
    Human 8-oxoguanine-DNA glycosylase (OGG1) is the major enzyme for repairing 8-oxoguanine (8-oxoG), a mutagenic guanine base lesion produced by reactive oxygen species (ROS)...
  9. doi Genetic polymorphism of DNA base-excision repair genes (APE1, OGG1 and XRCC1) and their correlation with risk of lung cancer in a Chinese population
    Zheng Li
    Department of Pathology, Third Military Medical University, Chongqing, China
    Arch Med Res 42:226-34. 2011
    ..base excision repair (BER) pathway could effectively remove oxidative lesions in which 8-oxoguanine glycosylase-1 (OGG1), x-ray repair cross-complementing 1 (XRCC1), and apurinic/apyimidinic endonuclease 1 (APE1) play key roles...
  10. pmc Poly(ADP-ribose) polymerase 1 (PARP-1) binds to 8-oxoguanine-DNA glycosylase (OGG1)
    Nicole Noren Hooten
    Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 286:44679-90. 2011
    Human 8-oxoguanine-DNA glycosylase (OGG1) plays a major role in the base excision repair pathway by removing 8-oxoguanine base lesions generated by reactive oxygen species...
  11. ncbi Associations between hOGG1 sequence variants and prostate cancer susceptibility
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Cancer Res 62:2253-7. 2002
    ..The hOGG1 gene encodes a DNA glycosylase/AP lyase that can suppress the mutagenic effects of 8-hydroxyguanine by catalyzing its removal from oxidized DNA...
  12. ncbi hOGG1 Ser326Cys polymorphism, interaction with environmental exposures, and gastric cancer risk in Japanese populations
    Hiromasa Tsukino
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104 0045, Japan
    Cancer Sci 95:977-83. 2004
    ..8-OHdG) formation is one of the most common types of oxidative DNA damage, while human oxoguanine glycosylase 1 (hOGG1) is responsible for repairing 8-OHdG lesions...
  13. ncbi hOGG1 Ser326Cys polymorphism and susceptibility to gallbladder cancer in a Chinese population
    Xingyuan Jiao
    Department of Hepatobiliary Surgery, Second Affiliated Hospital, Guangzhou Medical College, Guangzhou, Guangdong Province, The People s Republic of China
    Int J Cancer 121:501-5. 2007
    The human oxoguanine glycosylase 1(hOGG1) gene encodes a DNA glycosylase that is involved in excision repair of 8-OH-dG (8-hydroxy-2-deoxyguanine) from oxidatively-damaged DNA...
  14. ncbi Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 25:2177-81. 2004
    ..between single nucleotide polymorphisms (SNPs) in four genes (AKR1C3-Gln5His, NQO1-Pro187Ser, MnSOD-Val16Ala and OGG1-Ser326Cys) that play a role in the generation, prevention or repair of oxidative damage and lung cancer risk in a ..
  15. doi DNA repair gene hOGG1 codon 326 and XRCC1 codon 399 polymorphisms and bladder cancer risk in a Japanese population
    Katsuyuki Arizono
    Department of Public Health, Faculty of Medicine, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki, 889 1692 Japan
    Jpn J Clin Oncol 38:186-91. 2008
    ..There are many enzymes involved in BER. Human oxoguanine glycosylase 1 (hOGG1) and X-ray repair cross-complementing 1 (XRCC1) are enzyme genes of BER...
  16. doi Interactive effect of cigarette smoking with human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) polymorphisms on the risk of lung cancer: a case-control study in Taiwan
    Chin Hao Chang
    Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan, Republic of China
    Am J Epidemiol 170:695-702. 2009
    Human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) plays an important role in repairing oxidative DNA damage induced by tobacco carcinogens...
  17. pmc Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study
    Ilir Agalliu
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
    Cancer Causes Control 21:289-300. 2010
    ..Alterations of this pathway have been reported in many cancers. An increase in oxidative DNA damage or decrease in DNA repair capacity with aging or due to germline genetic variation may affect prostate cancer risk...
  18. ncbi Ser326Cys polymorphism in hOGG1 gene and risk of esophageal cancer in a Chinese population
    D Y Xing
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, China
    Int J Cancer 95:140-3. 2001
    Ser326Cys polymorphism in the hOGG1 gene, which is involved in the repair of 8-hydroxyguanine in oxidatively damaged DNA, has been identified and the variant genotype appears to be related to susceptibility to certain cancers...
  19. pmc Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the Ogg1 protein
    M Audebert
    CEA, Departement de Radiobiologie et Radiopathologie, UMR217 CNRS CEA, 60 avenue du général Leclerc, 92265 Fontenay aux Roses, France
    Nucleic Acids Res 28:2672-8. 2000
    ..amino acid substitutions of conserved arginines on the catalytic activities of the human Ogg1 protein (alpha-hOgg1-Ser(326)) (wild-type alpha-hOgg1)...
  20. ncbi Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk
    Loic Le Marchand
    Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA
    Cancer Epidemiol Biomarkers Prev 11:409-12. 2002
    ..A Ser326Cys substitution polymorphism in the hOGG1 gene has been suggested, based on in vitro data, to reduce the activity of the enzyme...
  21. ncbi Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects
    Pavel Vodicka
    Institute of Experimental Medicine, Videnska 1083, 14200, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Carcinogenesis 28:657-64. 2007
    ..The capacity to repair oxidative DNA damage was significantly decreased among individuals with hOGG1 Ser326Cys homozygous variant genotype (0.37 +/- 0.28 SSB/10(9) Da) compared to those with wild-type genotype (0...
  22. ncbi Association between polymorphism of human oxoguanine glycosylase 1 and risk of prostate cancer
    Lan Chen
    Genitourinary Division, H Lee Moffitt Cancer Center, University of South Florida, Tampa 33612, USA
    J Urol 170:2471-4. 2003
    The human oxoguanine glycosylase 1 (hOGG1) gene encodes a DNA glycosylase that is involved in excision repair of 8-OH-dG (8-hydroxy-2-deoxyguanine) from oxidatively damaged DNA...
  23. pmc Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations
    C Dherin
    CEA, DSV, DRR, UMR217 CNRS CEA, Radiobiologie Moléculaire et Cellulaire, Fontenay aux Roses, France
    Nucleic Acids Res 27:4001-7. 1999
    ..have investigated the substrate specificity of the major nuclear form of the human Ogg1 protein, referred as alpha-hOgg1, for excision of damaged bases from DNA exposed to gamma-irradiation...
  24. ncbi Product-assisted catalysis in base-excision DNA repair
    J Christopher Fromme
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Struct Biol 10:204-11. 2003
    ..To our knowledge, the present example represents the first documented case of product-assisted catalysis in an enzyme-catalyzed reaction...
  25. pmc The C-terminal alphaO helix of human Ogg1 is essential for 8-oxoguanine DNA glycosylase activity: the mitochondrial beta-Ogg1 lacks this domain and does not have glycosylase activity
    K Hashiguchi
    Laboratory of Molecular Gerontology, National Institute of Aging IRP, National Institutes of Health, Box1, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Nucleic Acids Res 32:5596-608. 2004
    The human Ogg1 glycosylase is responsible for repairing 8-oxo-7,8-dihydroguanine (8-oxoG) in both nuclear and mitochondrial DNA...
  26. ncbi Protection of INS-1 cells from free fatty acid-induced apoptosis by targeting hOGG1 to mitochondria
    Lyudmila I Rachek
    Department of Cell Biology and Neuroscience, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
    Diabetes 55:1022-8. 2006
    ..expression vector containing the gene for the DNA repair enzyme human 8-oxoguanine DNA glycosylase/apurinic lyase (hOGG1) downstream of the mitochondrial targeting sequence (MTS) from manganese superoxide dismutase...
  27. ncbi Association of genetic polymorphisms in the base excision repair pathway with lung cancer risk: a meta-analysis
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Lung Cancer 54:267-83. 2006
    ..Therefore, it is likely that the defining feature of future epidemiologic studies will be the simultaneous analysis of large samples of cases and controls...
  28. pmc A novel R229Q OGG1 polymorphism results in a thermolabile enzyme that sensitizes KG-1 leukemia cells to DNA damaging agents
    Jeff W Hill
    Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, United States
    Cancer Detect Prev 31:237-43. 2007
    Mutations and polymorphisms of OGG1, the major mammalian 8-oxoguanine repair activity, are associated with increased risk for several cancers...
  29. doi Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3
    A R Dallosso
    Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Gut 57:1252-5. 2008
    ..MUTYH functions in the DNA base excision repair pathway and has a key role in the repair of oxidative DNA damage...
  30. ncbi Bladder cancer and polymorphisms of DNA repair genes (XRCC1, XRCC3, XPD, XPG, APE1, hOGG1)
    Kamil Fehmi Narter
    Istanbul Universitesi Deneysel Tip Arastirma Enstitüsü, Molekuler Tip Anabilim Dali, Capa, Istanbul, Turkey
    Anticancer Res 29:1389-93. 2009
    ..The aim of this study was to investigate six of these genes (XRCC1, XRCC3, XPD, XPG, APE1, hOGG1) each of which has a separate role in these repair mechanisms...
  31. doi Expression and polymorphisms of gene 8-oxoguanine glycosylase 1 and the level of oxidative DNA damage in peripheral blood lymphocytes of patients with Alzheimer's disease
    Jolanta Dorszewska
    Laboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland
    DNA Cell Biol 28:579-88. 2009
    ..the level of 8-oxo-2'-deoxyguanosine (8-oxo2dG) and expression of three isoforms of 8-oxoguanine glycosylase 1 (OGG1), OGG1-1a, 1b, and 1c, and OGG1 protein and Ser326Cys and Arg46Gln polymorphisms of the OGG1 gene, in peripheral ..
  32. doi Do DNA repair genes OGG1, XRCC3 and XRCC7 have an impact on susceptibility to bladder cancer in the North Indian population?
    Ruchika Gangwar
    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, Uttar Pradesh, India
    Mutat Res 680:56-63. 2009
    ..Therefore, we sought to examine the correlation between single nucleotide polymorphisms in DNA repair genes and bladder cancer...
  33. pmc Polymorphisms in hOGG1 and XRCC1 and risk of prostate cancer: effects modified by plasma antioxidants
    Jianjun Zhang
    Department of Public Health, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Urology 75:779-85. 2010
    ..Accumulating evidence indicates that oxidative stress plays a role in prostate carcinogenesis...
  34. ncbi The Cys326 allele of the 8-oxoguanine DNA N-glycosylase 1 gene as a risk factor in smoking- and drinking-associated larynx cancer
    Elzbieta Pawlowska
    Department of Pediatric Dentistry, Medical University of Lodz, Lodz, Poland
    Tohoku J Exp Med 219:269-75. 2009
    ..Human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) deals with oxidative DNA damage, and the base changes in the hOGG1 gene may alter the susceptibility of the human ..
  35. ncbi A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer
    R Lu
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 7:397-407. 1997
    ..Although OG is known to be produced in and cleansed from mammalian genomes, the enzymes responsible for OG repair in these cells have remained elusive...
  36. ncbi Polymorphisms in estrogen bioactivation, detoxification and oxidative DNA base excision repair genes and prostate cancer risk
    Nora L Nock
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Carcinogenesis 27:1842-8. 2006
    ..b>hOGG1 is a key enzyme in short patch BER because it recognizes and performs initial excision of the most common form of ..
  37. pmc MUTYH Gln324His gene polymorphism and genetic susceptibility for lung cancer in a Japanese population
    Aiko Miyaishi
    Faculty of Health Sciences, Kobe University Graduate School of Medicine, Kobe, Japan
    J Exp Clin Cancer Res 28:10. 2009
    ..We investigated the interactions among the gene polymorphisms in DNA repair genes and lung cancer...
  38. doi GPX1 Pro(198)Leu polymorphism, erythrocyte GPX activity, interaction with alcohol consumption and smoking, and risk of colorectal cancer
    Rikke Dalgaard Hansen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark
    Mutat Res 664:13-9. 2009
    GPX1 encoding the enzyme glutathione peroxidase 1 (GPX1) and hOGG1 encoding the 8-oxoguanine glycosylase 1 (OGG1) may counteract oxidative stress and resulting DNA damage associated with lifestyle-related exposures...
  39. doi hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type
    Toshiki Okasaka
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Hum Genet 54:739-45. 2009
    Human 8-oxoguanine DNA glycosylase 1 (hOGG1) has a major role in the repair of 8-hydroxyguanine, a major promutagenic DNA lesion...
  40. doi Single-nucleotide polymorphisms in BER and HRR genes, XRCC1 haplotypes and breast cancer risk in Caucasian women
    Silvia Sterpone
    Department of Biology, Rome Tre University, Rome, Italy
    J Cancer Res Clin Oncol 136:631-6. 2010
    This study aimed to assess whether haplotypes in XRCC1 and SNPs in OGG1 and XRCC3 were associated with an increased risk of developing breast cancer (BC) and early adverse reactions after radiotherapy.
  41. doi The association of polymorphisms in DNA base excision repair genes XRCC1, OGG1 and MUTYH with the risk of childhood acute lymphoblastic leukemia
    M Stanczyk
    Department of Molecular Genetics, University of Lodz, Banacha 12 16 St, 90 237, Lodz, Poland
    Mol Biol Rep 38:445-51. 2011
    ..the association of polymorphisms in genes encoding three key proteins of DNA base excision repair (BER): the OGG1 Ser326Cys, the MUTYH Tyr165Cys and the XRCC1 Arg399Gln with the risk of childhood acute lymphoblastic leukemia (ALL)..
  42. ncbi Lack of influence of DNA repair gene OGG1 codon 326 polymorphisms of gastric cancer risk in the Kashmir valley
    M A Malik
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    Asian Pac J Cancer Prev 11:165-8. 2010
    ..repaired through activation of pathways involving polymorphic enzymes, including human 8-oxoguanine glycosylase 1 (OGG1)...
  43. ncbi Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China
    Wen Yi Huang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Carcinogenesis 29:100-5. 2008
    ..R399Q, rs25487), apurinic/apyrimidinic endonuclease (APEX1) (D148E, rs3136820) and 8-oxoguanine DNA glycosylase (OGG1) (S326C, rs1052133), in a population-based study of 411 biliary tract cancer cases (237 gallbladder, 127 bile duct ..
  44. doi No association between hOGG1, XRCC1, and XPD polymorphisms and risk of reflux esophagitis, Barrett's esophagus, or esophageal adenocarcinoma: results from the factors influencing the Barrett's adenocarcinoma relationship case-control study
    Heather R Ferguson
    Division of Gastroenterology, Belfast City Hospital, Belfast BT9 7AB, Northern Ireland
    Cancer Epidemiol Biomarkers Prev 17:736-9. 2008
    ..repaired through activation of pathways involving polymorphic enzymes, including human 8-oxoguanine glycosylase 1 (hOGG1), X-ray repair cross-complementing 1 (XRCC1), and xeroderma pigmentosum group D (XPD)...
  45. doi Single-nucleotide polymorphisms of DNA repair genes OGG1 and XRCC1: association with gallbladder cancer in North Indian population
    Anvesha Srivastava
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, UP, India
    Ann Surg Oncol 16:1695-703. 2009
    ..Cells overcome the DNA damage by repair mechanisms. Genetic variants of OGG1 and XRCC1, important enzymes participating in base excision repair pathway, may confer interindividual variations ..
  46. doi Polymorphisms in ERCC2, MSH2, and OGG1 DNA repair genes and gallbladder cancer risk in a population of Northern India
    Kshitij Srivastava
    Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Cancer 116:3160-9. 2010
    ..Genetic variants of DNA repair enzymes may lead to genetic instability and contribute to gallbladder (GB) carcinogenesis...
  47. ncbi hOGG1 Ser(326)Cys polymorphism and modification by environmental factors of stomach cancer risk in Chinese
    Toshiro Takezaki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Int J Cancer 99:624-7. 2002
    ..g., resulting in 8-hydroxyguanine adducts. Since a human counterpart exists for the yeast gene OGG1 (hOGG1) encoding an enzyme that repairs 8-hydroxyguanine, its polymorphism, Ser(326)Cys, might have potential as a ..
  48. ncbi hOGG1 Ser326Cys polymorphism and breast cancer risk among Asian women
    Ji Yeob Choi
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Breast Cancer Res Treat 79:59-62. 2003
    To evaluate the potential association between breast cancer risk and Ser326Cys polymorphism of hOGG1 gene, encoding for an enzyme involved in the base excision repair of 8-hydroxyguanine, hospital based case-control studies were ..
  49. ncbi Association of the hOGG1 Ser326Cys polymorphism with sporadic amyotrophic lateral sclerosis
    Fabio Coppede
    Department of Neurosciences, Neurological Clinic, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Neurosci Lett 420:163-8. 2007
    ..There is evidence that the Ser326Cys polymorphism of the human 8-oxoguanine DNA glycosylase 1 (hOGG1) gene is associated with a reduced DNA repair activity...
  50. ncbi A limited association of OGG1 Ser326Cys polymorphism for adenocarcinoma of the lung
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 12:258-65. 2002
    The 8-oxoguanine DNA glycosylase (OGG1) repairs DNA by removing 8-hydroxyguanine, a highly mutagenic oxidative DNA adduct. Recently, the gene for OGG1 was cloned and several polymorphisms have been reported...
  51. ncbi Mammalian 8-oxoguanine DNA glycosylase 1 incises 8-oxoadenine opposite cytosine in nuclei and mitochondria, while a different glycosylase incises 8-oxoadenine opposite guanine in nuclei
    Anne Jensen
    Danish Center for Molecular Gerontology, Department of Molecular Biology, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Biol Chem 278:19541-8. 2003
    ..Using liver extracts from mice knocked out for 8-oxoguanine DNA glycosylase 1 (OGG1), we demonstrated that OGG1 is the only glycosylase that incises 8-oxoA, when base-paired with cytosine in ..
  52. ncbi Association of the OGG1-Ser326Cys polymorphism with lung adenocarcinoma risk
    Takashi Kohno
    Biology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045
    Cancer Sci 97:724-8. 2006
    ..The OGG1 gene, encoding a glycosylase for 8-hydroxyguanine, an oxidatively damaged promutagenic base, has the polymorphism ..
  53. pmc DNA repair gene polymorphisms and risk of pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 426, Houston, TX 77030, USA
    Clin Cancer Res 15:740-6. 2009
    ..The current research was undertaken to examine the association between genetic variations in DNA repair and pancreatic cancer risk...
  54. doi Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage
    Janelle L Harris
    Queensland Institute of Medical Research, Radiation Biology and Oncology, Brisbane, Queensland 4029, Australia
    Hum Mol Genet 18:4102-17. 2009
    ..Here, we reveal reduced expression of PARP-1, apurinic endonuclease 1 (APE1) and OGG1 in AOA1 cells and demonstrate a requirement for PARP-1 in the recruitment of aprataxin to sites of DNA breaks...
  55. pmc Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase
    T A Rosenquist
    Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    Proc Natl Acad Sci U S A 94:7429-34. 1997
    ..We have identified and characterized mouse and human cDNAs encoding homologs of the 8-oxoguanine DNA glycosylase (ogg1) gene of Saccharomyces cerevisiae...
  56. ncbi Effect of human OGG1 1245C-->G gene polymorphism on 8-hydroxy-2'-deoxyguanosine levels of leukocyte DNA among patients undergoing chronic hemodialysis
    D C Tarng
    Institute of Clinical Medicine, Faculty of Medicine, National Yang Ming University, Taipei, Taiwan
    J Am Soc Nephrol 12:2338-47. 2001
    The effects of the human OGG1 gene (hOGG1) 1245C-->G polymorphism on the 8-hydroxy-2'-deoxyguanosine (8-OHdG) contents of peripheral leukocyte DNA were investigated among chronic hemodialysis patients...
  57. pmc Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs
    K Nishioka
    Department of Biochemistry, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Mol Biol Cell 10:1637-52. 1999
    We identified seven alternatively spliced forms of human 8-oxoguanine DNA glycosylase (OGG1) mRNAs, classified into two types based on their last exons (type 1 with exon 7: 1a and 1b; type 2 with exon 8: 2a to 2e)...
  58. ncbi Age-associated decrease of oxidative repair enzymes, human 8-oxoguanine DNA glycosylases (hOgg1), in human aging
    Shin Kuang Chen
    Institute of Environmental Health Sciences, National Yangming University, Taiwan
    J Radiat Res 44:31-5. 2003
    ..The 8-oxoguanine repair-specific enzyme 8-oxoguanine-DNA glycosylase (hOgg1) was recently cloned and was observed to conduct mainly short-patch base-excision repair...
  59. ncbi The human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) DNA repair enzyme and its association with lung cancer risk
    Jong Park
    Divisions of Cancer Control and Molecular Oncology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Pharmacogenetics 14:103-9. 2004
    ..The codon 326 polymorphism in the hOGG1 gene has been suggested to reduce DNA repair enzyme activity based on in vitro functional analysis...
  60. ncbi [Effects of oxidative DNA damage and genetic polymorphism of the glutathione peroxidase 1 (GPX1) and 8-oxoguanine glycosylase 1 (hOGG1) on lung cancer]
    Chul Ho Lee
    Department of Preventive Medicine, College of Medicine Chungbuk National University
    J Prev Med Public Health 39:130-4. 2006
    ..The aim of this case-control study was to investigate effects of oxidative stress and genetic polymorphisms of the GPX1 genes and the interaction between them in the carcinogenesis of lung cancer...
  61. doi Human 8-oxoguanine-DNA glycosylase 1 protein and gene are expressed more abundantly in the superficial than basal layer of human epidermis
    Arash Javeri
    Bosch Institute, Sydney Cancer Center, Dermatology Research Laboratories, The University of Sydney, NSW 2006, Australia
    DNA Repair (Amst) 7:1542-50. 2008
    Human 8-oxoguanine-DNA glycosylase 1 (hOGG1) repairs 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) which results from oxidation of guanine...
  62. doi The association of OGG1 Ser326Cys polymorphism and urinary 8-OHdG levels with lung cancer susceptibility: a hospital-based case-control study in Turkey
    Bensu Karahalil
    Faculty of Pharmacy, Department of Toxicology, Gazi University, Ankara, Turkey
    Arh Hig Rada Toksikol 59:241-50. 2008
    ..It is repaired by 8-hydroxyguanine DNA glycosylase 1 (OGG1), which has several polymorphisms...
  63. pmc Cardiac overexpression of 8-oxoguanine DNA glycosylase 1 protects mitochondrial DNA and reduces cardiac fibrosis following transaortic constriction
    Jianxun Wang
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Am J Physiol Heart Circ Physiol 301:H2073-80. 2011
    ..transgenic mice with cardiomyocyte-specific overexpression of the DNA repair enzyme 8-oxoguanine DNA glycosylase 1 (OGG1) isoform 2a...
  64. ncbi Common polymorphisms in the XPD and hOGG1 genes are not associated with the risk of colorectal cancer in a Polish population
    Tomasz Sliwinski
    Department of Molecular Genetics, University of Lodz, Lodz, Poland
    Tohoku J Exp Med 218:185-91. 2009
    ..Xeroderma pigmentosum group D (XPD) protein and human homolog of the 8-oxoguanine glycosylase 1 (hOGG1) are involved in nucleotide excision repair and base excision repair, respectively...
  65. pmc Assessing tumor mutations to gain insight into base excision repair sequence polymorphisms and smoking in colon cancer
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, 84132, USA
    Cancer Epidemiol Biomarkers Prev 18:3384-8. 2009
    ..a study of 1,604 incident colon cancer cases and 1,969 matched population-based controls genotyped for BER variants OGG1 (S326C) and XRCC1 (R194W, R280H, and R399Q), we found no associations with colon cancer overall...
  66. doi OGG1 Ser326Cys polymorphism and susceptibility to esophageal cancer in low and high at-risk populations of northern India
    Rohit Upadhyay
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareilly Road, Lucknow, 226014, India
    J Gastrointest Cancer 41:110-5. 2010
    ..b>OGG1 Ser326Cys gene polymorphism (rs1052133) has been found to be associated with different cancer susceptibilities and ..
  67. doi MUTYH Tyr165Cys, OGG1 Ser326Cys and XPD Lys751Gln polymorphisms and head neck cancer susceptibility: a case control study
    Tomasz Sliwinski
    Department of Molecular Genetics, University of Lodz, 12 16, 90 237, Lodz, Poland
    Mol Biol Rep 38:1251-61. 2011
    ..present study we investigated the association between three polymorphisms of the MUTYH (Tyr165Cys, rs34612342), the OGG1 (Ser326Cys, rs1052133) and the XPD (Lys751Gln, rs13181) genes with head and neck cancer risk...
  68. doi Oxidative stress, Helicobacter pylori, and OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln polymorphisms in a Turkish population with colorectal carcinoma
    Ayse Basak Engin
    Department of Toxicology, Faculty of Pharmacy, Gazi University, Ankara, Turkey
    Genet Test Mol Biomarkers 14:559-64. 2010
    The contribution of polymorphisms of DNA repair genes OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln in developing colorectal carcinoma is controversial...
  69. pmc HOGG1 polymorphism in atrophic gastritis and gastric cancer after Helicobacter pylori eradication
    Lei min Sun
    Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, Zhejiang Province, China
    World J Gastroenterol 16:4476-82. 2010
    To investigate the association between Ser326Cys human oxoguanine glycosylase 1 (hOGG1) polymorphism and atrophic gastritis and gastric cancer after Helicobacter pylori (H. pylori) eradication.
  70. pmc Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat
    Asgeir Brevik
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, California 90089, USA
    Cancer Epidemiol Biomarkers Prev 19:3167-73. 2010
    ..Carcinogens generated during meat cooking have been implicated as causal agents and can induce oxidative DNA damage, which elicits repair by the base excision repair (BER) pathway...
  71. doi hOGG1 Ser326Cys polymorphism and risk of childhood acute lymphoblastic leukemia in a Chinese population
    Qian Li
    Department of Hematology and Oncology, The Affiliated Nanjing Children s Hospital of Nanjing Medical University, Nanjing Department of Hematology and Oncology, The Affiliated Children s Hospital of Soochow University, Suzhou Department of Molecular and Genetic Toxicology, Cancer Center of Nanjing Medical University, Nanjing, China
    Cancer Sci 102:1123-7. 2011
    ..Repair of 8-oxoG by the base excision repair pathway involves the activity of human 8-oxoG DNA glycosylase 1 (hOGG1)...
  72. doi XRCC1 and hOGG1 genes and risk of nasopharyngeal carcinoma in North African countries
    Nadia Laantri
    Laboratory of Onco Virology, Institut Pasteur du Maroc, Casablanca, Morocco
    Mol Carcinog 50:732-7. 2011
    ..X-Ray repair cross-complementing protein 1 (XRCC1) and human 8-oxo-guanine glycosylase 1 (hOGG1) genes are involved in deoxyribonucleic acid (DNA) repair and were found associated with NPC risk in three Asian ..
  73. ncbi hOGG1 exon7 polymorphism and gastric cancer in case-control studies of Japanese Brazilians and non-Japanese Brazilians
    T Hanaoka
    Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, 6 5 1 Kashinoha, Kashiwa shi, 277 8577, Chiba, Japan
    Cancer Lett 170:53-61. 2001
    Polymorphism of hOGG1 may be capable of serving as a genetic marker for individual susceptibility to various cancers because of its role in the repair of oxyradical DNA damage...
  74. ncbi No association between OGG1 Ser326Cys polymorphism and breast cancer risk
    Ulla Vogel
    National Institute of Occupational Health, DK 2100 Copenhagen, Denmark
    Cancer Epidemiol Biomarkers Prev 12:170-1. 2003
  75. ncbi Human ribosomal protein S3 interacts with DNA base excision repair proteins hAPE/Ref-1 and hOGG1
    Vijay Hegde
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Biochemistry 43:14211-7. 2004
    ..it is shown here that hS3 positively interacts with the human base excision repair (BER) enzymes N-glycosylase/AP lyase OGG1 and APE/Ref-1...
  76. ncbi Induction of OGG1 gene expression by HIV-1 Tat
    Kenichi Imai
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601
    J Biol Chem 280:26701-13. 2005
    ..target for Tat, we performed gene expression profile analysis and found that Tat up-regulates the expression of the OGG1 (8-oxoguanine-DNA glycosylase-1) gene, which encodes an enzyme responsible for repairing the oxidatively damaged ..
  77. ncbi Polymorphisms of the human OGG1 gene in laryngeal cancer: implications in radiotherapy response and survival
    E Monteiro
    Portuguese Institute of Oncology, Crop, SA Porto, Molecular Oncology Unit, Rua Antonio Bernardino Almeida, 4200 072 Porto, Portugal
    Rev Laryngol Otol Rhinol (Bord) 126:135-40. 2005
    The human OGG1 (hOGG1) gene encodes a DNA glycosylase involved in the excision repair of 8-hydroxy-2'-deoxyguanine (8-OH-dG) from oxidatively-damaged DNA...
  78. doi The 8-oxoguanine DNA N-glycosylase 1 (hOGG1) Ser326Cys variant affects the susceptibility to Graves' disease
    Sevda Tanrikulu
    Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa, Turkey
    Cell Biochem Funct 29:244-8. 2011
    ..In humans, 8-oxoG is mainly repaired by 8-oxoguanine DNA N-glycosylase-1 (hOGG1), which is an essential component of the base excision repair (BER) pathway...
  79. ncbi Nasopharyngeal carcinoma and genetic polymorphisms of DNA repair enzymes XRCC1 and hOGG1
    En Yu Cho
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei 10018, Taiwan
    Cancer Epidemiol Biomarkers Prev 12:1100-4. 2003
    ..To evaluate this hypothesis, this study focused on effects of genetic polymorphisms of DNA repair genes hOGG1 and XRCC1 on the development of NPC...
  80. ncbi Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue
    H Aburatani
    Third Department of Internal Medicine, University of Tokyo, Bunkyo ku, Japan
    Cancer Res 57:2151-6. 1997
    ..MMH) has been identified in the EST database (for expressed sequence tags) through a homology search with yeast OGG1 protein...
  81. ncbi Expression of the OGG1-type 1a (nuclear form) protein in cancerous and non-cancerous human cells
    K Shinmura
    Biology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Int J Oncol 16:701-7. 2000
    The human OGG1 gene encodes 8-hydroxyguanine DNA glycosylase. By RT-PCR analysis, five novel type 1 transcripts, in addition to eight known types (OGG1-types 1a to 1c and 2a to 2e), were identified...
  82. pmc Human OGG1 undergoes serine phosphorylation and associates with the nuclear matrix and mitotic chromatin in vivo
    Francoise Dantzer
    Department of Molecular Biology, Institute of Medical Microbiology, University of Oslo, Rikshospitalet, Sognsvannveien 20, NO 0027 Oslo, Norway
    Nucleic Acids Res 30:2349-57. 2002
    ..In the present study, we have constructed a stable transfectant cell line expressing hOGG1 fused at the C-terminal end to green fluorescent protein (GFP) and investigated the cellular distribution of the ..
  83. ncbi Conditional targeting of the DNA repair enzyme hOGG1 into mitochondria
    Lyudmila I Rachek
    Department of Cell Biology and Neuroscience, College of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    J Biol Chem 277:44932-7. 2002
    ..an effort to better understand the physiological role of recombinant 8-oxoguanine DNA glycosylase/apurinic lyase (OGG1) in mtDNA repair, we constructed an expression vector containing the gene for OGG1 downstream of the mitochondrial ..
  84. pmc hOGG1 Ser326Cys polymorphism modifies the significance of the environmental risk factor for colon cancer
    Jae Il Kim
    Department of Surgery, Ilsan Paik Hospital, Inje University College of Medicine, 2240, Daehwa dong, Ilsan gu, Koyang shi, Kyunggi do 412 270, Korea
    World J Gastroenterol 9:956-60. 2003
    To determine the association of hOGG1 (8-oxoguanine glycosylase I, OGG1) polymorphism of Ser326Cys substitution with colon cancer risk and possible interaction with known environmental risk factors.
  85. ncbi Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1
    Stéphanie Marsin
    Departement de Radiobiologie et Radiopathologie, UMR 217 CNRS, Commissariat a l Energie Atomique, BP6, F 92265 Fontenay aux Roses, France
    J Biol Chem 278:44068-74. 2003
    ..Here, we report that XRCC1 interacts physically and functionally with hOGG1, the human DNA glycosylase that initiates the repair by BER of the mutagenic oxidized base 8-oxoguanine...
  86. ncbi Accumulation of the oxidative base lesion 8-hydroxyguanine in DNA of tumor-prone mice defective in both the Myh and Ogg1 DNA glycosylases
    Maria Teresa Russo
    Department of Environment and Primary Prevention, Istituto Superiore di Sanita, Rome, Italy
    Cancer Res 64:4411-4. 2004
    The OGG1 and MYH DNA glycosylases prevent the accumulation of DNA 8-hydroxyguanine. In Myh(-/-) mice, there was no time-dependent accumulation of DNA 8-hydroxyguanine in brain, small intestine, lung, spleen, or kidney...
  87. ncbi Rapid detection of single nucleotide polymorphisms related with lung cancer susceptibility of Chinese population
    Geyu Liang
    School of Public Health, Southeast University, Nanjing, 210009, China
    Cancer Lett 223:265-74. 2005
    ..In our study, the possibility of an association of CYP1B1, GSTP1 and hOGG1 genetic polymorphisms with lung cancer was investigated in Chinese population of Nanjing, by a new single ..
  88. ncbi GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer
    Rikke Hansen
    National Institute of Occupational Health, Copenhagen, Denmark
    Cancer Lett 229:85-91. 2005
    ..We assessed the association between polymorphisms in two genes involved in DNA repair of oxidative stress, GPX and OGG1, and risk of colorectal carcinoma or adenomas...
  89. ncbi hOGG1(326), XRCC1(399) and XRCC3(241) polymorphisms influence micronucleus frequencies in human lymphocytes in vivo
    Raluca A Mateuca
    Laboratorium voor Cellulaire Genetica, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussel, Belgium
    Mutagenesis 23:35-41. 2008
    A pooled analysis of five biomonitoring studies was performed to assess the influence of hOGG1(326), XRCC1(399) and XRCC3(241) gene polymorphisms on micronuclei (MN) frequency in human peripheral blood lymphocytes, as measured by the ex ..
  90. doi The hOGG1 Ser326Cys polymorphism and lung cancer risk: a meta-analysis
    Haixin Li
    Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, PR China
    Cancer Epidemiol Biomarkers Prev 17:1739-45. 2008
    The potentially functional polymorphism Ser326Cys in the human 8-oxoguanine DNA glycosylase (hOGG1) gene has been implicated in lung cancer risk, but published studies have mixed findings...
  91. pmc Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae
    J P Radicella
    Laboratoire de Radiobiologie du DNA, Commissariat a l Energie Atomique, Departement de Radiobiologie et Radiopathologie, UMR217 Centre National de la Recherche Scientifique, 92265 Fontenay aux Roses, France
    Proc Natl Acad Sci U S A 94:8010-5. 1997
    ..These results make this novel gene (hOGG1) a strong candidate for the human homolog of the yeast OGG1 and suggest an important role of its product in the ..
  92. ncbi Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer
    K Shinmura
    Biology Division, National Cancer Center Research Institute, Tokyo
    Jpn J Cancer Res 89:825-8. 1998
    DNA glycosylase, encoded by the hOGG1 gene, repairs 8-hydroxyguanine (oh8Gua), which is an oxidatively damaged mutagenic base...
  93. ncbi The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis
    S Boiteux
    CEA, DSV, Departement de Radiobiologie et Radiopathologie, UMR217 CNRS CEA Radiobiologie Moléculaire et Cellulaire, Fontenay aux Roses, 92265, France
    Arch Biochem Biophys 377:1-8. 2000
    ..In yeast, the OGG1 gene encodes a DNA glycosylase/AP lyase that excises 8-OH-G from DNA...
  94. ncbi DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, M D Anderson Cancer Center, The University of Texas, 1400 Holcombe Blvd, Box 426, Houston, TX 77030, USA
    Mutat Res 513:37-48. 2002
    ..Polymorphisms of the CYP1A1, CYP2E1, NAT1, NAT2, GSTM1, MnSOD, and hOGG1 genes were determined in these patients...
  95. ncbi Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase
    Magnar Bjørås
    Department of Molecular Biology, Institute of Medical Microbiology, University of Oslo, The National Hospital, Norway
    J Mol Biol 317:171-7. 2002
    ..These lesions are targeted by the N-DNA glycosylase hOgg1, which catalyses excision of the aberrant base followed by cleavage of the phosphate backbone directly 5' to the ..
  96. ncbi The human OGG1 DNA repair enzyme and its association with orolaryngeal cancer risk
    Abul Elahi
    Divisions of Cancer Control and Molecular Oncology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA
    Carcinogenesis 23:1229-34. 2002
    The human OGG1 (hOGG1) gene encodes a DNA glycosylase that is involved in the excision repair of 8-hydroxy-2'-deoxyguanine (8-OH-dG) from oxidatively-damaged DNA...
  97. ncbi Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility
    Noriaki Sunaga
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 11:730-8. 2002
    ..of damaged DNA in lung cells, NQO1-Pro187Ser, GSTT1-positive/null, GSTM1-positive/null, CYP1A1-Ile462Val, and OGG1-Ser326Cys, were examined for association with lung adenocarcinoma risk in a case-control study of 198 patients and ..
  98. ncbi Transcription factors NF-YA regulate the induction of human OGG1 following DNA-alkylating agent methylmethane sulfonate (MMS) treatment
    Mi Rha Lee
    Research Center for Proteineous Materials, Chosun University, 375 Seosuk dong, Gwangju 501 759, Korea
    J Biol Chem 279:9857-66. 2004
    A human 8-oxoguanine-DNA glycosylase (hOGG1) is the main enzyme that repairs 8-oxoG, which is a critical mutagenic lesion. There is a great deal of interest in the up- or down-regulation of OGG1 expression after DNA damage...
  99. ncbi Genetic polymorphism of hOGG1 and risk of pterygium in Chinese
    H C Kau
    Institute of Clinical Medicine, National Yang Ming University, and Department of Ophthalmology, Taoyuan Veterans Hospital, Taiwan, Republic of China
    Eye (Lond) 18:635-9. 2004
    ..a marker for the evaluation of photo-oxidative DNA damage, can be repaired by human 8-oxoguanine glycosylase I (hOGG1)...
  100. ncbi Mutational analysis of OGG1, MYH, MTH1 in FAP, HNPCC and sporadic colorectal cancer patients: R154H OGG1 polymorphism is associated with sporadic colorectal cancer patients
    I J Kim
    Korean Hereditary Tumor Registry, Cancer Research Institute and Cancer Research Center, Seoul National University, Seoul, Korea
    Hum Genet 115:498-503. 2004
    MYH, OGG1 and MTH1 are members of base excision repair (BER) families, and MYH germline mutations were recently identified in patients with multiple adenomas or familial adenomatous polyposis (FAP)...
  101. ncbi Are genetic polymorphisms in OGG1, XRCC1 and XRCC3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations?
    Peter Aka
    Laboratory for Cell Genetics, Department of Biology, Free University of Brussels, Pleinlaan 2, B 1050 Brussels, Belgium
    Mutat Res 556:169-81. 2004
    ..We have conducted a study to assess the predictivity of the OGG1, XRCC1 and XRCC3 genotypes and the in vitro single strand break repair phenotype for the induction of genotoxic ..

Research Grants62

  1. DNA Repair of Endogenous Lesions in Carcinogenesis
    Rabindra Roy; Fiscal Year: 2010
    ..Our preliminary results showed that DNA glycosylases (such as OGG1 and NTH1)-mediated excision activity of oxidized bases (8-oxoguanine and dihydrouracil) was significantly altered ..
  2. ISTVAN STEVEN BOLDOGH; Fiscal Year: 2014
    ..The base 8-oxoG is removed from the DNA by 8-oxoG DNA glycosylase 1 (OGG1) in the DNA base excision repair (BER) pathway...
  3. Repair of Oxidatively Damaged Guanines
    A LIEN L LU-CHANG; Fiscal Year: 2013
    ..2) The physical and functional Interactions of MYH (and Neil1, hOGG1 and hMSH2/hMSH6) with the 9-1-1 complex will be elucidated...
  4. SAMY LEWIZ HABIB; Fiscal Year: 2016
    ..The DNA repair enzyme that recognizes and excises 8-oxodG is 8- oxoG-DNA glycosylase (OGG1). Deficiency in OGG1 has important functional consequences, compromising the ability of cells to repair DNA...
  5. Oxidative Stress, Mitochondrial Dysfunction and Aging
    JOHN NMN PAPACONSTANTINOU; Fiscal Year: 2010
    ..P3 (IB) investigates the regulation of mtDNA repair by 8 oxo-guanine DNA glycosylase (OGG1), and whether the age-associated decline in mitochondrial function is caused by impaired/inefficient DNA repair due ..
  6. Structure and Mechanism in DNA Excision Repair
    GREGORY LAWRENCE VERDINE; Fiscal Year: 2013
    ..GO system that are responsible for either direct repair of the highly mutagenic lesion 8-oxoguanine (oxoG) - the hOgg1 enzyme in eukaryotes and MutM in prokaryotes - or repair of the mutagenic adenine in oxoG:A base-pair resulting ..
  7. Repair of Oxidized Bases in Mammalian Genomes
    Sankar Mitra; Fiscal Year: 2012
    ..Accumulation of oxidized base damage without a strong phenotype in mice lacking OGG1 and NTH1, the major mammalian glycosylases, suggested that additional glycosylases repair active genomic sequences...
  8. Mitochondrial DNA repair agents for acute lung injury
    Mark N Gillespie; Fiscal Year: 2012
    ..Indeed, genetic modulation of the first and rate-limiting step in mtDNA repair - mediated by Ogg1, a DNA glycosylase excises oxidatively damaged bases - coordinately regulates ROS-induced mtDNA damage and cell ..
  9. David W Kamp; Fiscal Year: 2016
    ..molecule, Noxa, as well as a novel mechanism by which mitochondrial human 8-oxoguanine-DNA glycosylase 1 (mt-hOgg1) prevents oxidant-induced intrinsic AEC apoptosis by preserving mitochondrial aconitase...
  10. David W Kamp; Fiscal Year: 2016
    ..implicate an important role for a novel mechanism by which mitochondrial human 8-oxoguanine-DNA glycosylase 1 (mt-hOgg1) prevents oxidant-induced intrinsic AEC apoptosis by preserving mitochondrial aconitase (Aco2)...
  11. DNA Repair Deficiency Associated with Obesity and the Metabolic Syndrome
    R Stephen Lloyd; Fiscal Year: 2013
    ..However, two knockout mouse models (neil1 and ogg1) have been created in which the initiation of base excision repair of oxidatively-damaged DNA is defective, and in ..
  12. DNA Damage and Repair in Parkinsons Disease
    Laurie H Sanders; Fiscal Year: 2011
    ..Expression of "GO" enzymes (OGG1, MUTY, and MTH1), proteins involved in the repair of oxidative DNA damage, were also found to be increased in the ..
  13. Age of Onset and Huntingtons Disease
    CYNTHIA THERESE MCMURRAY; Fiscal Year: 2010
    ..Loss of a single base excision repair enzyme, 8-oxo-guanine glycosylase (OGG1), in hHD/OGG1(-/-) mice stops age-dependent expansion of CAG triplet repeats that is observed in mhtt mice...
  14. Seongmin Lee; Fiscal Year: 2014
    ..Our preliminary study showed that human 8-oxoguanine glycosylase hOGG1 efficiently cleaves haloG from DNA, suggesting hOGG1 as a repair enzyme for haloG...
  15. John A D'Orazio; Fiscal Year: 2016
    ..by complementary measures of oxidative load (DCF-mediated fluorescence flow cytometry, Southwestern blotting, hOGG1-adapted Comet assay, TBARS assay, and direct quantification of oxidative DNA adducts by GC/MS)...
  16. DNA damage-induced regulation of base excision repair by dynamic localization
    NICHOLAS CHRISTOPHER BAUER; Fiscal Year: 2013
    ..the generality of dynamic compartmentalization by examining the localization of GFP-tagged BER proteins (Ung1, Ogg1, Apn1) in response to preferential genotoxic stress to nuclei or mitochondria...
  17. Prevention of Genetic Instability by Pomegranate in Ogg1/Myh Deficient Mice
    Ramune Reliene; Fiscal Year: 2009
    ..For example, alterations in OGG1 and MYH genes are associated with elevated risk of colorectal, lung, kidney and bladder cancer...
  18. DNA Damage and Neurodegeneration in the Aging Brain
    Bruce A Yankner; Fiscal Year: 2010
    ..complex that contains the longevity gene Sirtl, the transcriptional co-repressor NCOR1, and the DNA repair enzyme hOGG1. Our preliminary studies also raise the possibility that age-related ...
  19. HUMAN DNA REPAIR ENZYMES FOR REDOX AND ALKYLATION DAMAGE
    BRUCE F DEMPLE; Fiscal Year: 2010
    ..Determine the contribution of DNA glycosylases (in particular UNG2, OGG1, AAG/MPG, and NTH1) and of oxidative damage as sources of the lethal lesions that accumulate in Ape1-deficient ..
  20. Sarah Delaney; Fiscal Year: 2014
    ..Furthermore, the DNA repair enzyme OGG1, which is known to remove 8-oxoG from DNA duplexes, has also been linked to dynamic mutations...
  21. Oxidative DNA Damage, DNA Repair and Oral Cancer
    Chun Yang Fan; Fiscal Year: 2006
    ..for the repair of this specific DNA lesion was recently cloned and named human 8-oxoguanine DNA glycosylase (hOGG1)...
  22. Molecular Epidemiology of Chronic Liver Diseases
    Manal Hassan; Fiscal Year: 2009
    ..e., hOGG1 and XRCC1) between group 1 and group. 2)...
  23. PREQUEL Study In PRE-manifest HD of CoQ10/UbiquinonE Leading to Preventive Trials
    Christopher A Ross; Fiscal Year: 2010
    ..the relationships between serum levels of CoQ, biomarkers of oxidative stress, biomarkers of DNA repair mechanisms (OGG1) and dosage levels of CoQ...
  24. Raquel R Bartz; Fiscal Year: 2014
    ..The PI will investigate the role of the mitochondrial DNA repair (mDNA) enzyme, OGG1 and nuclear coactivators, PGC-11 and its family members, in mtDNA maintenance and biogenesis in a murine ..
  25. Leona D Samson; Fiscal Year: 2014
    ..response by examining mice deficient in one (or more) of numerous DNA repair proteins (Aag, Abh2, Abh3, Myh, Ogg1, and Mbd4)...
  26. DNA REPAIR OF MULTIPLY DAMAGED SITES IN CELLS
    Lynn Harrison; Fiscal Year: 2010
    ..MDSs that simulate ionizing radiation damage to assess the ability of the bacterial AP endonucleases, Fpg and Ogg1/Neil1 to convert MDSs to DSBs. MDSs will be examined that contain 2 or 3 lesions...
  27. Oxidative damage to DNA: implications for neurodegeneration in aging
    Fernando Cardozo-Pelaez; Fiscal Year: 2012
    ..We have used a mice model that is deficient or null for the expression of the enzyme 8-hydroxyglycosylase, Ogg1, required for the repair of oxo8dG...
  28. Prolonged Diabetic Damage to Cardiac Mitochondria
    Paul N Epstein; Fiscal Year: 2010
    ..background mitochondrial DNA will be protected by cardiac overexpression of MnSOD and mitochondrial targeted OGG1. We will also determine whether both DNA damage and diabetic cardiomyopathy are exacerbated by crossing existing ..
  29. Oxidative Stress, Antioxidants and Racial Disparities in Prostate Cancer
    Cathryn H Bock; Fiscal Year: 2011
    ..Tag SNPs in three genes in the oxidative stress pathway, SOD2, OGG1, and GPX1 will then be identified...
  30. Mark N Gillespie; Fiscal Year: 2016
    ..Accordingly, Specific Aim 2 will use wild type and mutant Ogg1 proteins differing in their capacities to repair - but not to bind - mtDNA to determine whether repair of RS-..
  31. Oxidative Stress, DNA Repair & Colorectal Adenoma Risk
    Michael Goodman; Fiscal Year: 2009
    ..We will also evaluate the SNPs of the main genes involved in DNA base excision repair including OGG1, APE1, XRCC1, ERCC5 and several others...
  32. Molecular Epidemiology of Smoking & Breast Cancer
    KATHLEEN CONWAY DORSEY; Fiscal Year: 2005
    ..whether common germline variants of the GST and NAT metabolizing enzymes, or of DNA repair enzymes (XRCC1, APE, HOGG1, XPA, XPD, XPF, and others), modify the prevalence of LOH or p53 mutations associated with smoking...
  33. Base excision repair in zebrafish development
    PHYLLIS STRAUSS; Fiscal Year: 2007
    ..Pathway entry is via a glycosylase, e.g., OGG1 or UDG, that recognizes the damage, e.g., 8-oxoG or the presence of uracil...
  34. Oxidative DNA Damage and the Analysis of 8-Oxyog Repair
    WALTER DEUTSCH; Fiscal Year: 2009
    ..In many instances N-glycosylases possess an intrinsic AP lyase activity that subsequently cleaves the abasic site, which in turn may be subject to delta-elimination depending ..
  35. Epidemiology of protein glutathiolation
    Joshua Muscat; Fiscal Year: 2009
    ..Measure the effects of alcohol consumption, diet, MnSOD and HOGG1 genetic polymorphisms on blood GSSP levels. 2...
  36. Prostate Microenvironmental & Prostate Cancer Progression
    June Chan; Fiscal Year: 2009
    ..e. MnSOD, GPX1, GSTM1, GSTT1, XRCC1, OGG1) are associated with: (Aim 1) prostate cancer clinical phenotype: (Aim 2) prostate tumor genomic instability: and (..
  37. Role of E2F1 in eugenol-mediated antiproliferative activity in melanoma cells
    Rita Ghosh; Fiscal Year: 2009
    ..As an immediate response E2F1 transactivates ogg1 to repair DNA base damage caused by eugenol...
  38. DNA Repair Biomarkers for Cancer Risk Assessment and Ea*
    Zvi Livneh; Fiscal Year: 2009
    ..Using that assay evidence was obtained to indicate that reduced OGG1 DNA repair activity is a risk factor in lung cancer...
  39. CELL BIOLOGY OF OXIDATIVE DNA DAMAGE AND REPAIR
    Miguel Berrios; Fiscal Year: 2004
    ..Similarly, there is little information regarding the intranuclear distribution of ogg1 and its molecular relationships with chromatin and structural components of the nucleus...
  40. Gene Regulation and DNA Damage in the Aging Brain
    Bruce Yankner; Fiscal Year: 2009
    ..co-repressor NCOR1, the human ortholog of the yeast longevity gene SIR2 (Sirt1), and the DNA repair enzyme hOGG1. Moreover, centenarian cases of extreme longevity show increased expression of DNA repair and anti-apoptotic genes ..
  41. MOUSE MODEL FOR OXIDATIVE DNA DAMAGE REPAIR
    Jeffrey Miller; Fiscal Year: 2004
    ..The OGG1 gene encodes a protein with a function similar to the bacterial MutM protein...
  42. Molecular Epidemiology of Colorectal Adenomas
    Robert Haile; Fiscal Year: 2005
    ..Specifically, we propose to study MTHFR, MTRR, ADH3, which may affect folate metabolism, and XRCC1, XRCC3, OGG1, and MGMT, which may be involved in DNA repair of damage associated with folate metabolism...
  43. Repair & Prevention of DNA Damage & Breast Cancer Risk
    Roy Shore; Fiscal Year: 2005
    ..nucleotide-excision repair pathway (XPC, XPD, XPF, XPG) or base-excision repair pathway (XRCC1, APE1, LIG3, POLD1, hOGG1) will be studied in relation to breast cancer risk...
  44. Molecular Epidemiology of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2008
    ..Such information will be valuable for the primary prevention of this deadly disease. ..
  45. Repair of oxidative damage in mammalian genomes
    Tapas K Hazra; Fiscal Year: 2010
    ..NEIL2 carries out a beta-delta-reaction like E. coli MutM/Nei, generating a 3'-P which is removed by polynucleotide kinase (PNK), but not by AP-endonuclease...
  46. Aging of the Nigrostriatal System: Role of DNA Repair
    Fernando Cardozo Pelaez; Fiscal Year: 2004
    ..Wild type and knockout mice will be challenged with the neurotoxin MPTP in order to detect changes in the dopaminergic neurons susceptibility as a consequence of aging and lack of DNA repair ..
  47. OXIDATIVE DNA DAMAGE AND REPAIR IN CNS CELLS
    Mark Kelley; Fiscal Year: 2003
    ..Specific Aim 1: Functional and biochemical characterization of the repair enzymes Ogg1, NTH, MTH, and MYH in the neuroblastoma cell lines SHSY5Y and Neuro-2A and in primary cultures of hippocampal ..
  48. Elucidation of epoxide hydrolase polymorphisms
    Jong Park; Fiscal Year: 2002
    ....
  49. CASE CONTROL STUDY OF RISK FACTORS FOR WILMS TUMOR
    Andrew Olshan; Fiscal Year: 2002
    ..This study will provide important new advances in our understanding of Wilms tumor given the study size, quality of exposure assessment, and incorporation of clinical and biological markers of etiologic heterogeneity. ..
  50. Imbalancing DNA BER to enhance Ovarian Tumor Sensitivity
    Mark Kelley; Fiscal Year: 2008
    ..abstract_text> ..
  51. TRANSFORMING GROWTH FACTOR BETA IN OXIDANT LUNG INJURY
    MICHAEL O REILLY; Fiscal Year: 2002
    ..These studies are significant because understanding how ROS injure and kill pulmonary epithelial cells is critically important for improving clinical therapies that rely on supplemental oxygen. ..
  52. CRYSTALLOGRAPHIC STUDIES OF EUKARYOTIC POLY(A)POLYMERASE
    SYLVIE DOUBLIE; Fiscal Year: 2006
    ..It is expected that these results will not only provide a sound structural basis for understanding the mechanism of polyadenylation at the molecular level but will also shed light on the mechanisms of processivity and repression. ..
  53. Gene Environment Interaction in Head and Neck Cancer
    Andrew Olshan; Fiscal Year: 2005
    ..The proposed study should contribute knowledge on gene-environment interactions for cancer of the head and neck, but also for other tobacco- and alcohol-related cancers and possibly cancers of unknown etiology. ..
  54. MECHANISTIC STUDIES OF DNA MISMATCH REPAIR
    A Lien Lu Chang; Fiscal Year: 2006
    ..Particularly, alterations in protein-protein interactions under oxidative stress will be investigated. These studies should advance our understanding of the role of DNA repair in genome stability and tumor susceptibility. ..
  55. Mechanisms of Motor Neuron Death
    Lee Martin; Fiscal Year: 2006
    ..abstract_text> ..
  56. Epigenetic Markers for Lung Cancer Detection
    Jong Park; Fiscal Year: 2006
    ..The proposed study will generate data that will be the groundwork for larger studies to validate the use of the identified methylation sites to develop markers for early lung cancer diagnosis. ..
  57. Protein alterations in skeletal muscle cells with improved mtDNA repair
    Lyudmila I Rachek; Fiscal Year: 2010
    ..Recently, we have reported that targeting the DNA repair protein hOGG1 in mitochondria augments mitochondrial DNA (mtDNA) repair and enhances cellular survival following oxidative ..
  58. Therapeutic/Mechanistic Role of Ape1 in Germ Cell Tumors
    Mark Kelley; Fiscal Year: 2007
    ..If any mutants are shown to sensitize the GCT cell lines to chemo-/IR agents, as expected, this will set the stage for future gene therapy approaches to sensitize GCT's to therapy. ..
  59. MECHANISM OF INDUCTION OF MALIGNANT GLIOMAS
    Demetrius Kokkinakis; Fiscal Year: 2002
    ..Genetic differences between tumor cells and those capable of infiltrating the normal parenchyma will also be identified and compared to those of initiated multipotent progenitor cells in order to understand their lineage. ..
  60. Repair of Oxidatively Damaged Guanines
    A Lien Lu Chang; Fiscal Year: 2008
    ..this context, the 9-1-1 proteins interact with and increase the activity of hMYH glycosylase, hNEIL1 glycosylase, hOGG1 glycosylase, and hMSH2/hMSH6 mismatch recognition complex...
  61. MECHANISMS OF NEURONAL APOPTOSIS IN VIVO
    Lee Martin; Fiscal Year: 2009
    ..This work can define a new mitochondrial mechanism for target deprivation-induced neurodegeneration and can improve the understanding of the cellular and molecular mechanisms of neuronal apoptosis in vivo ..
  62. Quality of Life of Testicular Cancer Survivors
    Yawei Zhang; Fiscal Year: 2008
    ..The increasing incidence of TC in young men, and the high survival rate, makes understanding the morbidity associated with TC survival a public health priority. [unreadable] [unreadable] [unreadable]..