OCA2

Summary

Gene Symbol: OCA2
Description: OCA2 melanosomal transmembrane protein
Alias: BEY, BEY1, BEY2, BOCA, D15S12, EYCL, EYCL2, EYCL3, HCL3, PED, SHEP1, P protein, P-protein, eye color 2 (central brown), eye color 3 (brown), hair color 3 (brown), melanocyte-specific transporter protein, oculocutaneous albinism II (pink-eye dilution homolog, mouse), pink-eyed dilution protein homolog, total brown iris pigmentation
Species: human

Top Publications

  1. pmc Association between a germline OCA2 polymorphism at chromosome 15q13.1 and estrogen receptor-negative breast cancer survival
    Elizabeth M Azzato
    J Natl Cancer Inst 102:650-62. 2010
  2. pmc Genetic testing for oculocutaneous albinism type 1 and 2 and Hermansky-Pudlak syndrome type 1 and 3 mutations in Puerto Rico
    Pedro J Santiago Borrero
    Department of Pediatrics, University of Puerto Rico School of Medicine, San Juan, Puerto Rico
    J Invest Dermatol 126:85-90. 2006
  3. ncbi Organization and sequence of the human P gene and identification of a new family of transport proteins
    S T Lee
    Department of Medical Genetics, University of Wisconsin School of Medicine, Madison 53706, USA
    Genomics 26:354-63. 1995
  4. ncbi A gene for the mouse pink-eyed dilution locus and for human type II oculocutaneous albinism
    E M Rinchik
    Biology Division, Oak Ridge National Laboratory, Tennessee 37831
    Nature 361:72-6. 1993
  5. ncbi P gene as an inherited biomarker of human eye color
    Timothy R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Epidemiol Biomarkers Prev 11:782-4. 2002
  6. ncbi Skin pigmentation, biogeographical ancestry and admixture mapping
    Mark D Shriver
    Department of Anthropology, Penn State University, 409 Carpenter Bld, University Park, PA 16802, USA
    Hum Genet 112:387-99. 2003
  7. pmc Control of confounding of genetic associations in stratified populations
    Clive J Hoggart
    Epidemiology Unit, London School of Hygiene and Tropical Medicine, Umited Kingdom
    Am J Hum Genet 72:1492-1504. 2003
  8. pmc MC1R mutations modify the classic phenotype of oculocutaneous albinism type 2 (OCA2)
    Richard A King
    Department of Genetics, University of Minnesota, Minneapolis, MN, 55455, USA
    Am J Hum Genet 73:638-45. 2003
  9. ncbi Allele variations in the OCA2 gene (pink-eyed-dilution locus) are associated with genetic susceptibility to melanoma
    Anne Sophie Jannot
    Unite INSERM 535 Génétique Epidémiologique et Structure des Populations Humaines, Hopital Paul Brousse, Villejuif, France
    Eur J Hum Genet 13:913-20. 2005
  10. pmc A three-single-nucleotide polymorphism haplotype in intron 1 of OCA2 explains most human eye-color variation
    David L Duffy
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Hum Genet 80:241-52. 2007

Research Grants

  1. Glycemic control in pediatric critical illness: The Ped-E-Trol trial
    MARK RANSFORD RIGBY; Fiscal Year: 2011
  2. A reconstructed skin model for development of treatments for albinism
    Seth J Orlow; Fiscal Year: 2010
  3. BM12: Brief Motivational Interviewing to Reduce Child BMI
    KEN A RESNICOW; Fiscal Year: 2012
  4. Ann M Reed; Fiscal Year: 2016
  5. Missing Mutations in Oculocutaneous and Ocular Albinism
    Richard Spritz; Fiscal Year: 2006
  6. Regressive evolution of pigmentation in the Mexican cavefish, Astyanax mexicanus
    Jessica A Lehoczky; Fiscal Year: 2010
  7. Nikolaos K Robakis; Fiscal Year: 2016
  8. Stefan J Riedl; Fiscal Year: 2015
  9. Exploring a Cessation Intervention for Low Income Smokers in an Emergency Setting
    E Melinda Mahabee-Gittens; Fiscal Year: 2013
  10. The function of proteins associated with albinism
    MURRAY BRILLIANT; Fiscal Year: 2005

Detail Information

Publications244 found, 100 shown here

  1. pmc Association between a germline OCA2 polymorphism at chromosome 15q13.1 and estrogen receptor-negative breast cancer survival
    Elizabeth M Azzato
    J Natl Cancer Inst 102:650-62. 2010
    ....
  2. pmc Genetic testing for oculocutaneous albinism type 1 and 2 and Hermansky-Pudlak syndrome type 1 and 3 mutations in Puerto Rico
    Pedro J Santiago Borrero
    Department of Pediatrics, University of Puerto Rico School of Medicine, San Juan, Puerto Rico
    J Invest Dermatol 126:85-90. 2006
    ..We describe screening 229 Puerto Rican OCA patients for these mutations, and for mutations in the OCA2 gene. We found the HPS1 mutation in 42.8% of cases, the HPS3 deletion in 17%, the TYR G47D mutation in 3...
  3. ncbi Organization and sequence of the human P gene and identification of a new family of transport proteins
    S T Lee
    Department of Medical Genetics, University of Wisconsin School of Medicine, Madison 53706, USA
    Genomics 26:354-63. 1995
    ..Mutations of the P gene result in type II oculocutaneous albinism (OCA2) in humans and pink-eyed dilution (p) in mice...
  4. ncbi A gene for the mouse pink-eyed dilution locus and for human type II oculocutaneous albinism
    E M Rinchik
    Biology Division, Oak Ridge National Laboratory, Tennessee 37831
    Nature 361:72-6. 1993
    ..The human P gene corresponds to the D15S12 locus within the chromosome segment 15q11-q13, which is typically deleted in patients with Prader-Willi and ..
  5. ncbi P gene as an inherited biomarker of human eye color
    Timothy R Rebbeck
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Epidemiol Biomarkers Prev 11:782-4. 2002
    ..The P gene is located on chromosome 15q11.2-q12, which is also the location of a putative eye pigmentation gene (EYCL3) inferred to exist by linkage analysis...
  6. ncbi Skin pigmentation, biogeographical ancestry and admixture mapping
    Mark D Shriver
    Department of Anthropology, Penn State University, 409 Carpenter Bld, University Park, PA 16802, USA
    Hum Genet 112:387-99. 2003
    ..We have also applied two methods of admixture mapping to test for the effects of three candidate genes (TYR, OCA2, MC1R) on pigmentation...
  7. pmc Control of confounding of genetic associations in stratified populations
    Clive J Hoggart
    Epidemiology Unit, London School of Hygiene and Tropical Medicine, Umited Kingdom
    Am J Hum Genet 72:1492-1504. 2003
    ..With only 32 markers informative for ancestry, the efficiency of the analysis is 70%. These methods can deal with both confounding and selection bias in genetic-association studies, making family-based designs unnecessary...
  8. pmc MC1R mutations modify the classic phenotype of oculocutaneous albinism type 2 (OCA2)
    Richard A King
    Department of Genetics, University of Minnesota, Minneapolis, MN, 55455, USA
    Am J Hum Genet 73:638-45. 2003
    ..Mutations in the P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2) in all eight, and mutations in the MC1R gene were responsible for the red (rather than yellow/blond) hair in the ..
  9. ncbi Allele variations in the OCA2 gene (pink-eyed-dilution locus) are associated with genetic susceptibility to melanoma
    Anne Sophie Jannot
    Unite INSERM 535 Génétique Epidémiologique et Structure des Populations Humaines, Hopital Paul Brousse, Villejuif, France
    Eur J Hum Genet 13:913-20. 2005
    The occuloalbinism 2 (OCA2) gene, localized at 15q11, encodes a melanosomal transmembrane protein that is involved in the most common form of human occulo-cutaneous albinism, a human genetic disorder characterized by fair pigmentation and ..
  10. pmc A three-single-nucleotide polymorphism haplotype in intron 1 of OCA2 explains most human eye-color variation
    David L Duffy
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Hum Genet 80:241-52. 2007
    We have previously shown that a quantitative-trait locus linked to the OCA2 region of 15q accounts for 74% of variation in human eye color...
  11. ncbi Genetic determinants of hair, eye and skin pigmentation in Europeans
    Patrick Sulem
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:1443-52. 2007
    ..3 is associated with freckles. The fifth region provided refinements to a previously reported association in OCA2, and the sixth encompasses previously described variants in MC1R.
  12. ncbi Mutation analysis in a family with oculocutaneous albinism manifesting in the same generation of three branches
    Markus N Preising
    Regensburg University Medical Center, Department of Pediatric Ophthalmology, Strabismology and Ophthalmogenetics, Franz Josef Strauss, Regensburg, Germany
    Mol Vis 13:1851-5. 2007
    ..To elucidate the molecular basis of oculocutaneous albinism with variable expressivity in a family from The Netherlands in which no consanguinity was reported...
  13. ncbi Association of polymorphic sites in the OCA2 gene with eye colour using the tree scanning method
    W Branicki
    Institute of Forensic Research, Section of Forensic Genetics, Westerplatte 9, Krakow, Poland
    Ann Hum Genet 72:184-92. 2008
    ..A number of genes are considered to affect normal variation in human pigmentation. Recent studies have indicated that OCA2 is the crucial gene involved in the high variation of iris colour present among populations of European descent...
  14. pmc Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet 82:411-23. 2008
    ..Single nucleotide polymorphisms (SNPs) in the HERC2 gene and, to a lesser extent, in the neighboring OCA2 gene were independently associated to iris color variation. OCA2 has been implicated in iris color previously...
  15. pmc A single SNP in an evolutionary conserved region within intron 86 of the HERC2 gene determines human blue-brown eye color
    Richard A Sturm
    Institute for Molecular Bioscience, University of Queensland, Brisbane QLD 4072, Australia
    Am J Hum Genet 82:424-31. 2008
    ..demonstrated that haplotypes of three single nucleotide polymorphisms (SNPs) within the first intron of the OCA2 gene are extremely strongly associated with variation in human eye color...
  16. doi A comprehensive genetic study of autosomal recessive ocular albinism in Caucasian patients
    Saunie M Hutton
    Human Medical Genetics Program, University of Colorado Denver, Anshutz Medical Campus, Aurora, Colorado 80045, USA
    Invest Ophthalmol Vis Sci 49:868-72. 2008
    ..a clinically mild presentation of oculocutaneous albinism (OCA), due to mutations in either the TYR (OCA1) or OCA2 (P) genes...
  17. pmc A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000074. 2008
    ..52). One variant in the MATP gene was associated with hair color. A variant in the HERC2 gene upstream of the OCA2 gene showed the strongest and independent association with hair color compared with other SNPs in this region, ..
  18. doi SLC45A2: a novel malignant melanoma-associated gene
    L P Fernandez
    Human Genetics Group, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Hum Mutat 29:1161-7. 2008
    ..A total of 23 SNPs in six candidate genes (ASP, OCA2, TYR, TYRP1, SILV, and SLC45A) belonging to the pigmentation pathway were genotyped...
  19. doi Analysis of cultured human melanocytes based on polymorphisms within the SLC45A2/MATP, SLC24A5/NCKX5, and OCA2/P loci
    Anthony L Cook
    Melanogenix Group, Institute for Molecular Bioscience, University of Queensland, Queensland, Australia
    J Invest Dermatol 129:392-405. 2009
    Single nucleotide polymorphisms (SNPs) within the SLC45A2/MATP, SLC24A5/NCKX5, and OCA2/P genes have been associated with natural variation of pigmentation traits in human populations...
  20. doi Birth prevalence and mutation spectrum in danish patients with autosomal recessive albinism
    Karen Grønskov
    edical Genetics Laboratory Center, Kennedy Center, Glostrup, Denmark
    Invest Ophthalmol Vis Sci 50:1058-64. 2009
    ..The study was initiated to investigate the mutation spectrum of four OCA genes and to calculate the birth prevalence in patients with autosomal recessive albinism...
  21. pmc Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians
    Hongmei Nan
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 125:909-17. 2009
    ..We evaluated the associations between 15 SNPs in 8 candidate pigmentation genes (TYR, TYRP1, OCA2, SLC24A5, SLC45A2, POMC, ASIP and ATRN) and both pigmentary phenotypes (hair color, skin color and tanning ability) ..
  22. pmc Multiple pigmentation gene polymorphisms account for a substantial proportion of risk of cutaneous malignant melanoma
    David L Duffy
    Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia
    J Invest Dermatol 130:520-8. 2010
    ..described the role of red hair (melanocortin-1 receptor, MC1R) and blue eye (oculocutaneous albinism type II, OCA2) gene polymorphisms in modulating the risk of cutaneous malignant melanoma (CMM) in a highly sun-exposed population ..
  23. ncbi Mutations of the P gene in oculocutaneous albinism, ocular albinism, and Prader-Willi syndrome plus albinism
    S T Lee
    Department of Medical Genetics, University of Wisconsin, Madison 53706
    N Engl J Med 330:529-34. 1994
    ..The P protein is a transmembrane polypeptide that may transport small molecules such as tyrosine, the precursor of melanin...
  24. ncbi Identification of P gene mutations in individuals with oculocutaneous albinism in sub-Saharan Africa
    R Kerr
    Department of Human Genetics, The South African Institute for Medical Research and University of the Witwatersrand, Johannesburg, South Africa
    Hum Mutat 15:166-72. 2000
    ..OCA type 2 (tyrosinase-positive) is the most common recessively inherited disorder among southern African Blacks. OCA2 is also seen in southern African Caucasoids, but is less frequent...
  25. ncbi A novel P gene missense mutation in a Japanese patient with oculocutaneous albinism type II (OCA2)
    Atsushi Kato
    Department of Dermatology, Osaka City University Graduate School of Medicine, 1 4 3, Asahimachi Abenoku, Osaka 545 8585, Japan
    J Dermatol Sci 31:189-92. 2003
    Oculocutaneous albinism type II (OCA2) is an autosomal recessively inherited disorder, characterized by white hair and skin, and loss of pigment in the eyes. Mutations in P gene have been shown to result in OCA2...
  26. ncbi Multilocus OCA2 genotypes specify human iris colors
    Tony Frudakis
    DNAPrint Genomics, Inc, 1621 W University Pkwy, Sarasota, FL 34243, USA
    Hum Genet 122:311-26. 2007
    ..Recent studies have shown that OCA2 polymorphism underlies most of the natural variability in human iris pigmentation but to date, only a few ..
  27. ncbi Distribution of two Asian-related coding SNPs in the MC1R and OCA2 genes
    I Yuasa
    Division of Legal Medicine, Faculty of Medicine, Tottori University, Yonago 683 8503, Japan
    Biochem Genet 45:535-42. 2007
    ..G1129A (R163Q) at the MC1R (melanocortin 1 receptor) gene and c.A1962G (H615R) at the OCA2 (oculocutaneous albinism type II) gene, were investigated in a total of 1,809 individuals in 16 populations from ..
  28. pmc Oculocutaneous albinism
    Karen Grønskov
    Kennedy Center, National Research Center for Genetics, visual Impairment and Mental Retardation, GL, Landevej 7, 2600 Glostrup, Denmark
    Orphanet J Rare Dis 2:43. 2007
    ..the most severe type with a complete lack of melanin production throughout life, while the milder forms OCA1B, OCA2, OCA3 and OCA4 show some pigment accumulation over time...
  29. ncbi Tyrosinase processing and intracellular trafficking is disrupted in mouse primary melanocytes carrying the underwhite (uw) mutation. A model for oculocutaneous albinism (OCA) type 4
    Gertrude E Costin
    Pigment Cell Biology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 116:3203-12. 2003
    ..The P protein and MATP have 12 transmembrane regions and are predicted to function as transporters...
  30. doi Inheritance of a novel mutated allele of the OCA2 gene associated with high incidence of oculocutaneous albinism in a Polynesian community
    Helene C Johanson
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
    J Hum Genet 55:103-11. 2010
    Oculocutaneous albinism type 2 (OCA2) is a human autosomal-recessive hypopigmentation disorder associated with pathological mutations of the OCA2 gene...
  31. ncbi Oculocutaneous albinism (OCA2) in sub-Saharan Africa: distribution of the common 2.7-kb P gene deletion mutation
    G Stevens
    Department of Human Genetics, School of Pathology, The South African Institute for Medical Research and University of the Witwatersrand, Johannesburg
    Hum Genet 99:523-7. 1997
    Oculocutaneous albinism (OCA2) is the most common autosomal recessive disorder in the South African Negroid population, occurring with a prevalence of 1/3900 individuals. The OCA2 locus, P, has been mapped to chromosome 15q11-q13 and a 2...
  32. ncbi Oculocutaneous albinism with TYRP1 gene mutations in a Caucasian patient
    Caroline Rooryck
    Service de Genetique Medicale, Centre Hospitalier Universitaire, Bordeaux, France
    Pigment Cell Res 19:239-42. 2006
    ..heterogeneous autosomal recessive disorder with mutations identified in several genes: OCA1 (tyrosinase, TYR), OCA2 (OCA2), OCA3 (tyrosinase-related protein 1, TYRP1), and OCA4 (membrane-associated transporter protein, MATP)...
  33. pmc Functional interactions between OCA2 and the protein complexes BLOC-1, BLOC-2, and AP-3 inferred from epistatic analyses of mouse coat pigmentation
    Diego J Hoyle
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Pigment Cell Melanoma Res 24:275-81. 2011
    ..b>OCA2, the product of the gene defective in oculocutaneous albinism type 2, is a melanosomal membrane protein with ..
  34. ncbi [Prenatal diagnosis of oculocutaneous albinism type II and discovery of two novel mutations]
    Hong yi Li
    Department of Medical Genetics, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou 510080, China
    Zhonghua Yi Xue Za Zhi 87:1123-5. 2007
    To investigate the genotype of oculocutaneous albinism type II (OCA2) and perform prenatal gene diagnosis for OCA2.
  35. ncbi Prenatal diagnosis of oculocutaneous albinism type II and novel mutations in two Chinese families
    Li Hongyi
    Department of Medical Genetics, Zhongshan Medical College, Sun Yat Sen University, Guangzhou, Guangdong Province, China
    Prenat Diagn 27:502-6. 2007
    The prenatal genetic diagnosis and counseling of oculocutaneous albinism type II (OCA2) by detecting mutations in the OCA2 gene
  36. doi High resolution mapping of OCA2 intragenic rearrangements and identification of a founder effect associated with a deletion in Polish albino patients
    Caroline Rooryck
    Laboratoire de Génétique Humaine EA4137, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux, France
    Hum Genet 129:199-208. 2011
    Oculocutaneous albinism type 2 (OCA2) represents about 30% of OCA worldwide...
  37. doi Distribution of OCA2∗481Thr and OCA2∗615Arg, associated with hypopigmentation, in several additional populations
    Isao Yuasa
    Division of Legal Medicine, Faculty of Medicine, Tottori University, Yonago 683 8503, Japan
    Leg Med (Tokyo) 13:215-7. 2011
    Two mutants, OCA2∗481Thr (c.1441G>A, p.Ala481Thr) and OCA2∗615Arg (c.1844A>G, p.His615Arg), in the OCA2 (oculocutaneous albinism type II) gene are associated with hypopigmentation in East Asians...
  38. ncbi [DNA-based diagnosis of Angelman syndrome and Prader-Willi syndrome]
    S Saitoh
    Department of Human Genetics, Nagasaki University School of Medicine
    No To Hattatsu 25:501-7. 1993
    ..repeat polymorphism (DNRP) analyses revealed that 67% of AS patients have DNA deletions ranging from D15S9 to D15S12 loci. An exception was 3 sib cases whose deletion involved only 2 loci, D15S10 and GABRB3...
  39. ncbi Determinants of antipyretic misuse in children up to 5 years of age: a cross-sectional study
    Natalya Bilenko
    The S Daniel Abraham International Center for Health and Nutrition, Ben Gurion University of the Negev, Beer Sheva, Israel
    Clin Ther 28:783-93. 2006
    ....
  40. ncbi [Dynamic study on effect of Chinese medicine compound Yiliuyin on angiogenesis in transplanted S180 tumor of mouse]
    Zhipeng Han
    Department of Immunology, Institute of Basic Medical Science, Hebei Medical University, Shijiazhuang 050017, China
    Zhongguo Zhong Yao Za Zhi 34:212-6. 2009
    ....
  41. ncbi Characterization of OCA2 cDNA in different porcine breeds and analysis of its potential effect on skin pigmentation in a red Iberian strain
    A Fernandez
    Departamento de Mejora Genética Animal, SGIT INIA, Crta Coruna km 7, 28040 Madrid, Spain
    Anim Genet 37:166-70. 2006
    Although the function of the OCA2 gene product has not been totally clarified, variation in OCA2 has been associated with skin and hair pigmentation in human and mouse...
  42. ncbi Albinism (OCA2) in Amerindians
    Charles M Woolf
    School of Life Sciences, Arizona State University, Tempe, Arizona 85287 4501, USA
    Am J Phys Anthropol . 2005
    ..2-12 results in tyrosinase-positive albinism (OCA2)...
  43. ncbi Analysis of litter size and weight in mice differing in Ped gene phenotype and the Q region of the H-2 complex
    C M Warner
    Department of Biology, Northeastern University, Boston, MA 02115
    J Reprod Immunol 19:303-13. 1991
    A gene has been described, Ped (Preimplantation embryo development), that influences the rate of cleavage of preimplantation mouse embryos...
  44. pmc Functional adaptation of venous smooth muscle response to vasoconstriction in proximal, distal, and varix segments of varicose veins
    Joseph D Raffetto
    Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Vasc Surg 51:962-71. 2010
    ....
  45. ncbi Angiographic and flow patterns of retinal choroidal anastomoses in age-related macular degeneration with occult choroidal neovascularization
    Ruth Axer-Siegel
    Department of Ophthalmology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Ophthalmology 109:1726-36. 2002
    ....
  46. ncbi Antibiotic resistance patterns of uropathogens in pediatric emergency department patients
    Thomas George McLoughlin
    Department of Emergency Medicine, University of Florida, Jacksonville, FL, USA
    Acad Emerg Med 10:347-51. 2003
    To evaluate the prevalence of resistance of the various urinary tract infection (UTI) pathogens obtained from patients in an urban pediatric emergency department (PED), and to identify risk factors for infection with resistant strains.
  47. ncbi A health promotion intervention for families in a Medicaid managed care plan
    V T Chande
    Department of Pediatrics, University of Pittsburgh, Children s Hospital of Pittsburgh, PA, USA
    Acad Emerg Med 6:823-7. 1999
    To determine whether implementation of an intervention based on a model of health promotion will encourage patients to seek care from their primary care provider (PCP) and reduce visits to the pediatric ED (PED) for minor illness.
  48. ncbi Coding of pediatric behavioral and mental disorders
    Jerry L Rushton
    Child Health Evaluation and Research Unit, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109 0456, USA
    Pediatrics 110:e8. 2002
    ..However, very little information is available on how physicians who care for children approach diagnosis and coding dilemmas for behavioral and mental disorders, which often present unique additional challenges...
  49. ncbi Genetics and imaging to assess oocyte and preimplantation embryo health
    C M Warner
    Department of Biology, Northeastern University, Boston, MA 02115, USA
    Reprod Fertil Dev 16:729-41. 2004
    ..A major gene that regulates the rate of preimplantation development is the preimplantation embryo development (Ped) gene, discovered in our laboratory...
  50. doi Tracheal intubation practice and maintaining skill competency: survey of pediatric emergency department medical directors
    Joseph D Losek
    Pediatric Department, Medical University of South Carolina, SC 29425, USA
    Pediatr Emerg Care 24:294-9. 2008
    ..The purpose of this survey study was to determine the practice of TI in pediatric emergency departments (PEDs) and the methods used by PED medical directors to maintain TI competency among PED physicians.
  51. ncbi Evaluation of epithelial cell proliferating activity and fibroblast nuclear kariometry in recurrent pterygium treated with mitomycin C
    Gildasio Castello de Almeida Junior
    Departamento de Oftalmologia, Faculdade de Medicina de Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP, Brasil
    Arq Bras Oftalmol 71:568-75. 2008
    ..Ki-67 antigen to evaluate epithelial cell proliferation and fibroblast nuclear kariometry were used to assist treatment evaluation...
  52. ncbi [Adjacent segment degeneration after lumbosacral fusion in spondylolisthesis: a retrospective radiological and clinical analysis]
    P Zencica
    Ortopedická klinika FN Brno Bohunice
    Acta Chir Orthop Traumatol Cech 77:124-30. 2010
    ..Clinical evaluations included back pain or neurologic symptomatology which emerged later in the post-operative period in patients with adjacent segment degeneration...
  53. ncbi A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A
    V C Dodelet
    Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 274:31941-6. 1999
    ..Using a yeast two-hybrid screen, we have identified a novel signaling intermediate, SHEP1 (SH2 domain-containing Eph receptor-binding protein 1), which is expressed in the embryonic and adult brain...
  54. ncbi Survey of academic pediatric emergency departments regarding use of evaluation and management codes
    Joseph D Losek
    Division of Pediatric Emergency Critical Care, Medical University of South Carolina, Charleston, USA
    Pediatr Emerg Care 21:578-81. 2005
    ..to identify factors associated with their use by academic pediatric emergency departments (PEDs), and to compare PED E/M code utilization rates with rates reported by Centers for Medicare and Medicaid Services for general emergency ..
  55. pmc Lower Miocene stratigraphy along the Panama Canal and its bearing on the Central American Peninsula
    Michael Xavier Kirby
    Center for Tropical Paleoecology and Archaeology, Smithsonian Tropical Research Institute, Balboa, Republic of Panama
    PLoS ONE 3:e2791. 2008
    ..of a stratigraphic dispute: To wit, is the terrestrial Cucaracha Formation older or younger than the marine La Boca Formation? Previous stratigraphic studies of the Panama Canal Basin have suggested that the Cucaracha Formation ..
  56. doi Optical coherence tomography-measured pigment epithelial detachment height as a predictor for retinal pigment epithelial tears associated with intravitreal bevacizumab injections
    Clement K Chan
    Southern California Desert Retina Consultants, Palm Springs, California 92263, USA
    Retina 30:203-11. 2010
    ..tomography-related factors in age-related macular degeneration eyes with retinal pigment epithelial detachment (PED) that may predispose retinal pigment epithelial (RPE) tears associated with intravitreal bevacizumab injections.
  57. ncbi Angiographic lesion of polypoidal choroidal vasculopathy on indocyanine green and fluorescein angiography
    Fumi Gomi
    Department of Ophthalmology, Osaka University Medical School, Yamadaoka, Suita, Japan
    Graefes Arch Clin Exp Ophthalmol 245:1421-7. 2007
    ..The purpose of this study was to evaluate angiographic findings and compare the lesion sizes of PCV on ICGA and FA using confocal scanning laser ophthalmoscopy (SLO) and fundus camera...
  58. doi Morphologic changes in acute central serous chorioretinopathy evaluated by fourier-domain optical coherence tomography
    Hisataka Fujimoto
    Department of Ophthalmology, Osaka University Medical School, Suita, Osaka, Japan
    Ophthalmology 115:1494-500, 1500.e1-2. 2008
    ..To investigate morphologic alterations around fluorescein leakage sites using Fourier-domain optical coherence tomography (FD OCT) in acute central serous chorioretinopathy (CSC)...
  59. pmc GLUT1 mutations are a cause of paroxysmal exertion-induced dyskinesias and induce hemolytic anemia by a cation leak
    Yvonne G Weber
    Neurologische Klinik and Institut für Anatomie und Zellbiologie, Universitat Ulm, Ulm, Germany
    J Clin Invest 118:2157-68. 2008
    ..In this study, we describe a family with paroxysmal exertion-induced dyskinesia (PED) over 3 generations...
  60. ncbi [Clinical experience of percutaneous endoscopic gastrostomy, jejunostomy, duodenostomy in 120 patients]
    Zhi Wei Jiang
    Research Institute of General Surgery, General Hospital of Nanjing Military Area, Nanjing 210002, China
    Zhonghua Wai Ke Za Zhi 43:18-20. 2005
    ..To report clinical experience of percutaneous endoscopic gastrostomy, duodenostomy, jejunostomy in 120 patients, focusing on its technique and indications...
  61. ncbi Computer modeling of patient flow in a pediatric emergency department using discrete event simulation
    Geoffrey R Hung
    Division of Emergency Medicine, Department of Pediatrics, BC Children s Hospital, Vancouver, British Columbia, Canada
    Pediatr Emerg Care 23:5-10. 2007
    ..Accurate predictions of patient flow and resource utilization in the pediatric emergency department (PED) are important in determining what aspects of PED activity could be modified to improve patient flow, reduce ..
  62. ncbi Insertion of long lines in the pediatric emergency department
    A M Arnett
    Department of Pediatric Emergency Medicine, Boston Medical Center, Boston University, Massachusetts 02118, USA
    Pediatr Emerg Care 15:318-21. 1999
    The purpose of this study was: 1) to evaluate the role of the pediatric emergency department (PED) in placing peripherally inserted midline or central catheters (long lines), and 2) to review indications and complications to use this ..
  63. doi Fever phobia: a survey of caregivers of children seen in a pediatric emergency department
    Michael P Poirier
    Eastern Virginia Medical School, Children s Hospital of the King s Daughters, Norfolk, 23507, USA
    Clin Pediatr (Phila) 49:530-4. 2010
    Fever continues to be the most common complaint of children seen in a Pediatric Emergency Department (PED). Previous studies have assessed the prevalence of fever phobia in various populations...
  64. doi Impact of sexual assault nurse examiners on the evaluation of sexual assault in a pediatric emergency department
    Kirsten Bechtel
    Department of Pediatrics, Yale University School of Medicine, and Section of Pediatric Emergency Medicine, Yale New Haven Children s Hospital, New Haven, CT 06504, USA
    Pediatr Emerg Care 24:442-7. 2008
    ..To date, the effectiveness of sexual assault nurse examiners (SANEs) on the evaluation and management of pediatric and adolescent sexual assault victims in a pediatric emergency department (PED) has not been evaluated.
  65. ncbi Posterior lumbar epidural fat as a functional structure? Histologic specificities
    R Beaujeux
    Department of Radiology A, Hpitaux Universitaires de Strasbourg, France
    Spine (Phila Pa 1976) 22:1264-8; discussion 1269. 1997
    ..A topographic and histologic study was done to describe the location of the lumbar epidural fat and to find potential tissular specificities...
  66. doi Evaluation of a web-based asynchronous pediatric emergency medicine learning tool for residents and medical students
    Kreg Burnette
    Department of Pediatric Emergency Medicine, University Medical Center, St Rose Dominican Hospital Siena, KB Las Vegas, NV, USA
    Acad Emerg Med 16:S46-50. 2009
    ....
  67. doi Intravitreal injection of triamcinolone combined with bevacizumab for choroidal neovascularization associated with large retinal pigment epithelial detachment in age-related macular degeneration
    Leila el Matri
    Department B of Ophthalmology, Hedi Rais Institute of Ophthalmology, Boulevard 9 avril 1006 Bab saadoun, Tunis, Tunisia
    Graefes Arch Clin Exp Ophthalmol 248:779-84. 2010
    ..triamcinolone acetonide (IVTA) injection with intravitreal bevacizumab (IVB) in treating choroidal neovascularization (CNV) associated with large retinal pigment epithelial detachment (PED) in age-related macular degeneration (AMD).
  68. ncbi Ceftriaxone use in the emergency department: are we doing it right?
    Shabnam Jain
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    Pediatr Emerg Care 18:259-64. 2002
    To evaluate the patterns of ceftriaxone use in an urban pediatric emergency department (PED) and to determine if overuse exists based on published guidelines for management of febrile infants.
  69. ncbi Usefulness of the serum electrolyte panel in the management of pediatric dehydration treated with intravenously administered fluids
    Joe E Wathen
    Department of Pediatrics, Section of Emergency Medicine, University of Colorado Health Sciences Center Children s Hospital, Denver, Colorado, USA
    Pediatrics 114:1227-34. 2004
    ..Our study purpose was to evaluate the usefulness of routinely ordering a SEP in the treatment of dehydrated pediatric patients receiving intravenous fluids (IVFs)...
  70. pmc Effects of supplementary urea-minerals lick block on the kinetics of fibre digestion, nutrient digestibility and nitrogen utilization of low quality roughages
    Yue Ming Wu
    College of Animal Sciences, Zhejiang University, Hangzhou 310029, China
    J Zhejiang Univ Sci B 6:793-7. 2005
    ..RS and hay had similar values in the potential extent of digestion (PED) and digestion rate of PED (kd) of fibrous materials, but the discrete lag time for RS was lower than that for hay...
  71. doi A mindfulness-based group psychoeducational intervention targeting sexual arousal disorder in women
    Lori A Brotto
    University of British Columbia, Vancouver, British Columbia, Canada
    J Sex Med 5:1646-59. 2008
    ..In recent years, mindfulness has been incorporated into sex therapy and has been found effective for genital arousal disorder among women with acquired sexual complaints secondary to gynecologic cancer...
  72. doi Predictors of anti-VEGF-associated retinal pigment epithelial tear using FA and OCT analysis
    Allen Chiang
    Jules Stein Eye Institute, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095, USA
    Retina 28:1265-9. 2008
    ..tomography (OCT) predictors for retinal pigment epithelial (RPE) tear in eyes with pigment epithelium detachment (PED) associated with neovascular age-related macular degeneration treated with intravitreal vascular endothelial growth ..
  73. doi [Nasal foreign body in infants]
    I Claudet
    Service d Urgences Pédiatriques, Hopital des Enfants, Toulouse Cedex 9, France
    Arch Pediatr 16:1245-51. 2009
    Provide a descriptive analysis of children admitted to a tertiary care pediatric emergency department (PED) for a nasal foreign body (NFB) and describe the current knowledge and management of such accidents.
  74. doi The effect of Pediococcus acidilactici on the gut microbiota and immune status of on-growing red tilapia (Oreochromis niloticus)
    R M W Ferguson
    Aquaculture and Fish Nutrition Research Group, School of Marine Science and Engineering, Marine Institute, University of Plymouth, Plymouth, UK
    J Appl Microbiol 109:851-62. 2010
    ..To assess Pediococcus acidilactici as a dietary supplement for on-growing red tilapia (Oreochromis niloticus)...
  75. pmc Streptococcal pharyngitis: impact of a high-sensitivity antigen test on physician outcome
    C A Needham
    Department of Laboratory Medicine, Lahey Clinic, Burlington, Massachusetts, USA
    J Clin Microbiol 36:3468-73. 1998
    ..a walk-in clinic (WIC), primarily saw adult patients, and one clinic, a pediatric and adolescent medicine clinic (PED), primarily saw pediatric patients...
  76. doi Prescribing errors in a pediatric emergency department
    Michael L Rinke
    Department of Pediatrics, Johns Hopkins Hospital, Baltimore, MD, USA
    Pediatr Emerg Care 24:1-8. 2008
    To determine the frequency, prescriber, and type of prescribing errors in written in-house orders and ambulatory prescriptions in a pediatric emergency department (PED).
  77. pmc Rewirable gene regulatory networks in the preimplantation embryonic development of three mammalian species
    Dan Xie
    Department of Bioengineering, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Genome Res 20:804-15. 2010
    Mammalian preimplantation embryonic development (PED) is thought to be governed by highly conserved processes...
  78. doi Genetic analysis of three important genes in pigmentation and melanoma susceptibility: CDKN2A, MC1R and HERC2/OCA2
    Maider Ibarrola-Villava
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Exp Dermatol 19:836-44. 2010
    ..The OCA2 gene has emerged as a new and significant determinant of human iris colour variation...
  79. pmc Differential gene expression of TRPM1, the potential cause of congenital stationary night blindness and coat spotting patterns (LP) in the Appaloosa horse (Equus caballus)
    Rebecca R Bellone
    Department of Biology, University of Tampa, Tampa, FL 33606, USA
    Genetics 179:1861-70. 2008
    ..the relative expression of two functional candidate genes located in this LP candidate region (TRPM1 and OCA2), as well as three other linked loci (TJP1, MTMR10, and OTUD7A) by quantitative real-time RT-PCR...
  80. ncbi Polypoidal choroidal vasculopathy: natural history
    Masanobu Uyama
    Department of Ophthalmology, Kansai Medical University, Moriguchi, Osaka, Japan
    Am J Ophthalmol 133:639-48. 2002
    ..The present study was performed to clarify the long-term natural history of polypoidal choroidal vasculopathy (PCV)...
  81. ncbi Pediatric emergency department directors' benchmarking survey: fiscal year 2001
    Kathy N Shaw
    Division of Emergency Medicine, The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Pediatr Emerg Care 19:143-7. 2003
    ..To answer basic questions, using precise definitions, regarding emergency department (ED) utilization, wait times, services, and attending physician staffing of representative pediatric EDs (PEDs)...
  82. ncbi Inhibition of xenogeneic response in porcine endothelium using RNA interference
    Min Zhu
    Key Laboratory of Organ Transplantation, Ministry of Education Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Transplantation 79:289-96. 2005
    ..In this study, we use siRNA for silencing of alpha1,3GT with the purpose of reducing expression of the alpha-Gal epitope and subsequently decreasing immunogenicity of porcine endothelial cells...
  83. ncbi Percutaneous endoscopic discectomy for far lateral lumbar disc herniations: prospective study and outcome of 66 patients
    M Sasani
    Neurosurgery Department, VKV American Hospital, Istanbul, Turkey
    Minim Invasive Neurosurg 50:91-7. 2007
    ..Numerous surgical approaches have been described. Percutaneous endoscopic discectomy (PED) is one of the minimally invasive techniques; after mastering this procedure it is a practical method that is used ..
  84. ncbi Protein kinase C (PKC)-alpha activation inhibits PKC-zeta and mediates the action of PED/PEA-15 on glucose transport in the L6 skeletal muscle cells
    G Condorelli
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy
    Diabetes 50:1244-52. 2001
    Overexpression of the PED/PEA-15 protein in muscle and adipose cells increases glucose transport and impairs further insulin induction...
  85. ncbi Raised expression of the antiapoptotic protein ped/pea-15 increases susceptibility to chemically induced skin tumor development
    Pietro Formisano
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Via Sergio Pansini, 5, Naples 80131, Italy
    Oncogene 24:7012-21. 2005
    b>ped/pea-15 is a cytosolic protein performing a broad antiapoptotic function...
  86. ncbi Retinal pigment epithelial tear after ranibizumab therapy for subfoveal fibrovascular pigment epithelial detachment
    C K Chan
    Southern California Desert Retina Consultants, Palm Springs, CA 92263, USA
    Eur J Ophthalmol 17:674-6. 2007
    To describe the unusual complication of retinal pigment epithelial (RPE) tear after intravitreal ranibizumab (Lucentis) for subfoveal fibrovascular pigment epithelial detachment (PED) and its effective management.
  87. ncbi Initial validation of the Pediatric Automated Neuropsychological Assessment Metrics for childhood-onset systemic lupus erythematosus
    Hermine I Brunner
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Arthritis Rheum 57:1174-82. 2007
    To evaluate the concurrent validity and diagnostic accuracy of the pediatric Automated Neuropsychological Assessment Metrics (Ped-ANAM) when used in childhood-onset systemic lupus erythematosus (SLE).
  88. doi The cytokinesis-block micronucleus assay as a biological dosimeter for targeted alpha therapy
    Emma Y Song
    Centre for Experimental Radiation Oncology, Cancer Care Centre, St George Hospital, Gray St, 2217 Kogarah, Australia
    Phys Med Biol 53:319-28. 2008
    ..Absorbed dose (MIRD) and effective total body dose (PED) were calculated...
  89. doi Unusual noncovalent interaction between the chelated Cu(II) ion and the pi bond in the vitamin B(13) complex, cis-diammine(orotato)copper(II): theoretical and vibrational spectroscopy studies
    K Helios
    Faculty of Chemistry, Wrocław University of Technology, Wybrzeze Wyspianskiego 27, 50 370 Wrocław, Poland
    J Phys Chem B 113:8158-69. 2009
    ..and Raman spectra of the title complex has been made on the basis of the calculated potential energy distribution, PED. It is shown that an extremely intense band at 1210 cm(-1) in the Raman spectrum of cis-[Cu(oro)(NH(3))(2)] is ..
  90. ncbi The diagnosis of pulmonary embolism
    A Celi
    Dipartimento Cardiotoracico e Vascolare, University of Pisa, Italy
    Monaldi Arch Chest Dis 71:47-53. 2009
    ..end, three clinical rules have been proposed and validated (the revised Geneva score, the Wells score and the PISA-PED score) while others await clinical validation...
  91. doi Influence of the substituents on the structure and properties of benzoxaboroles
    Agnieszka Adamczyk-Woźniak
    Warsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, 00 664 Warsaw, Poland
    J Phys Chem A 114:2324-30. 2010
    ..The harmonic frequencies, potential energy distribution (PED), and IR intensities of this compound and its deuterated analogue were calculated with the B3LYP method...
  92. pmc Evaluation of Fructooligosaccharides and Inulins as Potentially Health Benefiting Food Ingredients by HPAEC-PED and MALDI-TOF MS
    Chiara Borromei
    Dipartimento di Chimica Generale ed Inorganica, Chimica Analitica, Chimica Fisica, Universita di Parma, Viale Usberti 17 A, 43100 Parma, Italy
    Int J Anal Chem 2009:530639. 2009
    ..of high-performance anion exchange chromatography coupled with pulsed electrochemical detection (HPAEC-PED) and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF-MS) to evaluate commercial available ..
  93. doi Temperature dependent Raman study of S(B)-->S(C) transition in liquid crystalline compound N-(4-n-pentyloxybenzylidene)-4'-heptylaniline (5O.7)
    K Vikram
    Department of Physics, Banaras Hindu University, Varanasi 221005, India
    Spectrochim Acta A Mol Biomol Spectrosc 75:1480-5. 2010
    ..7) has been done. Vibrational assignment and potential energy distribution (PED) of individual modes have been calculated employing density functional theory (DFT) for the first time...
  94. doi Photodynamic therapy for variant central serous chorioretinopathy: efficacy and side effects
    B Gupta
    St Thomas Hospital, London, UK
    Ophthalmologica 225:207-10. 2011
    Retinal pigment epithelial detachment (PED) is a recognised associated finding in central serous chorioretinopathy (CSC)...
  95. doi Live CT imaging of sound reception anatomy and hearing measurements in the pygmy killer whale, Feresa attenuata
    Eric W Montie
    Department of Science and Mathematics, University of South Carolina Beaufort, Bluffton, SC 29909, USA
    J Exp Biol 214:945-55. 2011
    In June 2008, two pygmy killer whales (Feresa attenuata) were stranded alive near Boca Grande, FL, USA, and were taken into rehabilitation...
  96. doi DFT, FT-Raman and FT-IR investigations of 5-o-tolyl-2-pentene
    Cemal Parlak
    Department of Physics, Dumlupinar University, 43100 Kutahya, Turkey
    Spectrochim Acta A Mol Biomol Spectrosc 79:1077-83. 2011
    ..Furthermore, reliable vibrational assignments have made on the basis of potential energy distribution (PED) calculated...
  97. doi Retinal pigment epithelial tears and the management of exudative age-related macular degeneration
    Andrew J Barkmeier
    Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA
    Semin Ophthalmol 26:94-103. 2011
    ..Eyes with vascularized retinal pigment epithelial detachments (PED) are especially at risk for the development of RPE tears...
  98. doi Delayed spontaneous rupture of a posterior inferior cerebellar artery aneurysm following treatment with flow diversion: a clinicopathologic study
    M Chow
    Division of Neurosurgery, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    AJNR Am J Neuroradiol 33:E46-51. 2012
    ..the fatal spontaneous delayed rupture of a previously unruptured large PICA aneurysm following treatment with the PED. Pathology at postmortem examination has supported the theory that intra-aneurysmal thrombus may acutely ..
  99. doi Automated characterization of pigment epithelial detachment by optical coherence tomography
    Sun Young Lee
    Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 53:164-70. 2012
    To assess the accuracy of automated classification of pigment epithelial detachments (PED) by using a software algorithm applied to spectral-domain optical coherence tomography (SD-OCT) scans.
  100. pmc A model-based approach for analysis of spatial structure in genetic data
    Wen Yun Yang
    Interdepartmental Program in Bioinformatics, University of California, Los Angeles, California, USA
    Nat Genet 44:725-31. 2012
    ..These regions include SNPs in the well-characterized LCT region, as well as at loci including FOXP2, OCA2 and LRP1B.
  101. doi Complications after treatment with pipeline embolization for giant distal intracranial aneurysms with or without coil embolization
    Adnan H Siddiqui
    Department of Neurosurgery, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
    Neurosurgery 71:E509-13; discussion E513. 2012
    The Pipeline Embolization Device (PED) is a flow diverter designed to treat intracranial aneurysms through endoluminal parent vessel reconstruction. The role of adjunctive coil embolization is unknown.

Research Grants70

  1. Glycemic control in pediatric critical illness: The Ped-E-Trol trial
    MARK RANSFORD RIGBY; Fiscal Year: 2011
    ..more conservative control in children requiring intensive care. The "Ped-E-Trol" ("Pediatric ICUs at Emory Glycemic Control) Trial will study 1,004 children admitted to the ICU for medical,..
  2. A reconstructed skin model for development of treatments for albinism
    Seth J Orlow; Fiscal Year: 2010
    ..Oculocutaneous albinism type 2 (OCA2) is an autosomal recessive disorder resulting from mutations in the OCA2 gene...
  3. BM12: Brief Motivational Interviewing to Reduce Child BMI
    KEN A RESNICOW; Fiscal Year: 2012
    ..Group 2 (PED only) will include the same assessments, enrollment criterion and educational materials as UC...
  4. Ann M Reed; Fiscal Year: 2016
    ....
  5. Missing Mutations in Oculocutaneous and Ocular Albinism
    Richard Spritz; Fiscal Year: 2006
    ..albinism (OCA) involves the eyes, skin and hair, and is associated with mutations in four genes: TYR, OCA2, TYRP1, and MATP...
  6. Regressive evolution of pigmentation in the Mexican cavefish, Astyanax mexicanus
    Jessica A Lehoczky; Fiscal Year: 2010
    ..Our previous QTL analyses and mutation screening implicate both Mc1r and Oca2 as important pigmentation genes in Astyanax...
  7. Nikolaos K Robakis; Fiscal Year: 2016
    ..evidence that the PS1/[unreadable]-secretase system regulates the expression of miR-212 that targets the mRNA of PED/PEA-15 (PEA15), a protein known to promote cell survival under reduced glucose...
  8. Stefan J Riedl; Fiscal Year: 2015
    ..resistance is the SH2 domain-containing protein BCAR3, a member of a family of three proteins that also includes SHEP1, which we identified in a screen for Eph receptor tyrosine kinase-binding molecules...
  9. Exploring a Cessation Intervention for Low Income Smokers in an Emergency Setting
    E Melinda Mahabee-Gittens; Fiscal Year: 2013
    ..6 million parents who smoke visit pediatric emergency departments (PED) annually...
  10. The function of proteins associated with albinism
    MURRAY BRILLIANT; Fiscal Year: 2005
    ..function of the proteins encoded by the P and MATP genes that are associated with forms of oculocutaneous albinism (OCA2 and OCA4, respectively)...
  11. Cholinergic and noradrenergic inputs to early olfactory processing
    Christiane Linster; Fiscal Year: 2010
    ..Neural activity in the locus coeruleus and horizontal limb of the diagonal band of Boca will be recorded in rats performing one of three different olfactory tasks...
  12. Andrea C Gielen; Fiscal Year: 2016
    ..that demonstrated some success in a low income, urban, and predominantly African-American population in a single PED. This proposal will test an enhanced web-based program, Safety in Seconds v 2.0 (SIS v2...
  13. Conformations and Dynamics of PED/PEA-15 in Protein-Protein Interactions
    Yufeng Wei; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): There is a fundamental gap in understanding how PED/PEA-15 (phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocyte, 15 kDa), a small, non-catalytic protein, can regulate a number of ..
  14. A novel therapeutic for the treatment of persistent corneal epithelial defects
    Bennie H Jeng; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Persistent epithelial defects (PED) of the cornea are uncommon, but in addition to the immediate adverse effect on vision, persistent defects can have serious consequences for the health of the eye ..
  15. ANTHONY NMN SPIRITO; Fiscal Year: 2016
    ..S. pediatric emergency departments (PED), by pursuing two specific aims: Primary Aim 1) To determine the concurrent, convergent, discriminant, and ..
  16. Appropriate Care of URI in Children of Latino Immigrants: The ACURI Project
    Melissa S Stockwell; Fiscal Year: 2010
    ..literacy levels regarding upper respiratory infections (URIs) and to decrease pediatric emergency department (PED) visits, among Latino households in Early Head Start/Head Start...
  17. James D Geiger; Fiscal Year: 2015
    ..As part of the FDA's initial Pediatric Grant Program (P50), the Michigan Pediatric Device Consortium (M-PED) was established and was expanded to include several collaborations...
  18. MOLECULAR BASIS OF THE PED GENE PHENOTYPE
    Carol Warner; Fiscal Year: 1999
    ..One embryonic gene, Ped (Preimplantation embryo development), determines the rate (fast or slow) at which preimplantation mouse embryos ..
  19. Advancing Opportunities for Ped. Research and the Role of CC-CHOC within NCATS
    Frederick Kaskel; Fiscal Year: 2013
    ..An ongoing annual program evaluation will be reviewed by the Organizing and Scientific Committees in order to assure a continued successful engagement of the scientific community attending the FTF and PAS meetings. ..
  20. PED GENE ACTION IN DEVELOPMENT AND REPRODUCTION
    Carol Warner; Fiscal Year: 2005
    ..One example is the mouse Preimplantation embryo development (Ped) gene...
  21. SMOKING INTERVENTIONS FOR LOW INCOME PREGNANT WOMEN
    Judith Ockene; Fiscal Year: 1999
    ..during pregnancy and postpartum; 2) obstetricians (OB) and clinic staffs during pregnancy; and 3) pediatricians (PED) and clinic staffs during postpartum...
  22. POLYCHELATING AGENT INCORPORATION LIPOSOMES & MICELLES
    John Babich; Fiscal Year: 1999
    ..b>PED-PE-based micelles will be prepared containing variable quantities of DTPA-PLL-PE will be prepared...
  23. COMPLIANCE WITH CHILD SUPPORT ORDERS
    CHRISTOPHER FLINN; Fiscal Year: 1992
    ..In Del Boca and Flinn (1990), we construct a model in which the behavior of divorced parents and institutional actors can be ..
  24. Simplified Pump Oxygenator for Pediatric Use Phase II
    Mark Gartner; Fiscal Year: 2003
    Ension, Inc. is seeking to complete the development of an integrated cardiopulmonary bypass system, Ped- AMMO, that is specifically designed for use in neonatal and small-sized pediatric patients, less than 10 kg body weight...
  25. Brief Child Safety Interventions in Emergency Department
    Andrea Gielen; Fiscal Year: 2004
    ..driven and innovative brief intervention for child safety delivered in the Pediatric Emergency Department (PED) of the Johns Hopkins Hospital, which serves a high risk, inner city population...
  26. EFFICACY/RELIABILITY OF TELEMED IN ROUTINE PED PRACTICE
    Kenneth McConnochie; Fiscal Year: 2000
    ....
  27. HUMAN FACTORS TO DESIGN SAFE PEDIATRIC SEDATION SYSTEMS
    George Blike; Fiscal Year: 2003
    ..Scenarios will be reproducible using a pediatric simulator (Ped-sim TM, Medical Education Technologies, Inc.)...
  28. ROLE OF THE MHC IN EARLY MAMMALIAN DEVELOPMENT
    Carol Warner; Fiscal Year: 1992
    ..The second part of this proposal deals with a gene we discovered about 10 years ago, the MHC-linked Ped (Preimplantation embryo development) gene, which controls the rate of cleavage of preimplantation mouse embryos...
  29. COGNITIVE-BEHAVIORAL TREATMENT OF PED TRICHOTILLOMANIA
    Martin Franklin; Fiscal Year: 2003
    ....
  30. PEDRIATRIC HYDROXYUREA PHASE III CLINICAL TRIAL CLINICAL
    Winfred Wang; Fiscal Year: 2001
    ..disease trials, the Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH) and the Pediatric Hydroxyurea (PED HUG) Trial...
  31. PEDIATRIC HYDROXYUREA PHASE III CLINICAL TRIAL - MCC
    Michael Terrin; Fiscal Year: 2000
    ..disease trials, the Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH) and the Pediatric Hydroxyurea (PED HUG) Trial...
  32. Dev. of a Risk Adj. Model for Ped. Rehab. Patients w/ABI
    Sydney Rice; Fiscal Year: 2002
    ..This model can then be used in the evaluation of the effectiveness of interventions in experimental and observational studies. It will also facilitate risk-adjusted evaluation of pediatric rehabilitation programs. ..
  33. PEDIATRIC HYDROXYUREA PHASE III CLINICAL TRIAL
    Catherine Driscoll; Fiscal Year: 2000
    ..disease trials, the Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH) and the Pediatric Hydroxyurea (PED HUG) Trial...
  34. Ped Endocrine Career Development in Diabetes Research
    Charles Stanley; Fiscal Year: 2007
    ..The Program is strongly supported by access to a superb range of institutional resources, including the CHOP GCRC and the UPenn DERC. Request is made for 2 Appointee slots in this Program each year. ..
  35. Lightweight Electronically Controlled Transdermal Patch for Enfuvirtide Delivery
    MAUREEN MULVIHILL; Fiscal Year: 2009
    ..I NIH SBIR, will develop a Lightweight Electronically Controlled Transdermal Patch for Enfuvirtide Delivery (LET-PED). Thirty-three million people worldwide are living with the Human Immunodeficiency Virus (HIV)...
  36. Bacterial Locomotion and Signal Transduction VIII Mtg.
    ROBERT KADNER; Fiscal Year: 2005
    ..Conference on Bacterial Locomotion and Signal Transduction (BLAST VIII) will be held January 16-20, 2005, in Boca Raton, Florida...
  37. COORDINATION DYNAMICS OF HUMAN BRAIN AND BEHAVIOR
    J Kelso; Fiscal Year: 2001
    ..a full-head, neuromagnetic imaging device at CTF Systems, Vancouver, functional and conventional MRI facilities in Boca Raton, and direct contact with eminent theoreticians who share my interests...
  38. Pre-College Matriculation Risk Profiles and Freshman Drinking Trajectories
    Jerod Stapleton; Fiscal Year: 2009
    ..In addition, patterns of heavy alcohol use during the college experience have been established (Del Boca et al., 2004;Goudriaan et al., 2007)...
  39. TRIPTORELIN FOR OVARY PROTECTION IN CHILDHOOD LIPUS
    Hermine Brunner; Fiscal Year: 2007
    ..Abstract Not Provided ..
  40. High Density Association Analysis of Lung Cancer
    Christopher I Amos; Fiscal Year: 2010
    ..We are collaborating with the International Lung Cancer Consortium so that it can further validate our findings for a variety of different populations, in future initiatives. ..
  41. Clinical and Neuropsychological Investigations in Batten Disease
    Jonathan W Mink; Fiscal Year: 2010
    ..Although JNCL is a rare disease, our research has implications that can be generalized to the study of other degenerative neurologic disorders in children and for preparing translational clinical trials in these diseases. ..
  42. Nucleotide Excision Repair Gene Variants and Skin Cancer
    Jiali Han; Fiscal Year: 2005
    ..abstract_text> ..
  43. Virtual Reality Kinetopsic 3D Recognition in AD & aMCI
    Victoria Pelak; Fiscal Year: 2005
    ..abstract_text> ..
  44. METABOLISM OF THE VLDL RECEPTOR AND APOE RECEPTOR 2
    Joachim Herz; Fiscal Year: 2009
    ..This may provide novel targets for rational drug design and treatment of atherosclerosis as well as of AD, both disorders of increasing medical and socio-economic importance. ..
  45. RANDOMIZED TRIAL OF THE BRIEF NEGOTIATED INTERVIEW
    Edward Bernstein; Fiscal Year: 2002
    ....
  46. University Life Transitions Telephone Diary Study
    Jennifer Maggs; Fiscal Year: 2003
    ..variation in alcohol expectancies, use, consequences, and affect using HLM. ..
  47. IDENTIFYING NIDDM GENES USING ADMIXED POPULATIONS
    Mark Shriver; Fiscal Year: 2001
    ..They will verify any positive associations found using sib-pair linkage analysis and the transmission disequilibrium test. ..
  48. PROTEIN PAINTING OF PREIMPLANTATION EMBRYOS
    Carol Warner; Fiscal Year: 2003
    ..one gene that influences growth rate of preimplantation embryos and pregnancy outcome has been identified, the Ped gene. The product of the Ped gene is Qa-2 protein...
  49. Pharmacogenetic Epidemiology of Birth Defects and Cancer
    Timothy Rebbeck; Fiscal Year: 2004
    ....
  50. Genetic and Tissue Engineering for Aneurysms
    David Kallmes; Fiscal Year: 2004
    ..Successful implementation of this research program will advance the field of genetic and tissue engineering and will improve the care of patients harboring life-threatening cerebral aneurysms. ..
  51. Cohort Study of Genetic Susceptibility to Cutaneous Malignant Melanoma
    Jiali Han; Fiscal Year: 2010
    ..This research will contribute to the scientific basis for identifying individuals at high risk for melanoma and providing individualized risk management strategies. ..
  52. Molecular Bases for Effects of Nicotine
    RONALD LUKAS; Fiscal Year: 2007
    ..Insights will also be provided into the kinds of drugs that block or mimic nicotine's actions. Collectively, this knowledge will benefit development of strategies to treat mood, cognitive, and other nervous system disorders. ..
  53. Human Pigmentation Candidate Gene Variation and Signals of Localized Adaptation
    Heather Norton; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  54. Statistical Methods for Gene Environment Interactions In Lung Cancer
    Christopher Amos; Fiscal Year: 2009
    ..The simulation approaches and analytical discoveries from our research will be widely distributed. (End of Abstract) ..
  55. The Value of Health in Adolescents with Chronic Illness
    MICHAEL YI; Fiscal Year: 2008
    ..The challenge and the major strength of this research agenda is its integration of behavioral and social science paradigms with clinical disease information. ..