Genomes and Genes
Gene Symbol: NYX
Alias: CLRP, CSNB1, CSNB1A, CSNB4, NBM1, nyctalopin, leucine-rich repeat protein
Publications239 found, 100 shown here
- Mutations in NYX, encoding the leucine-rich proteoglycan nyctalopin, cause X-linked complete congenital stationary night blindnessN T Bech-Hansen
Department of Medical Genetics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
Nat Genet 26:319-23. 2000..NYX, which encodes a glycosylphosphatidyl (GPI)-anchored protein called nyctalopin, is a new and unique member of the small leucine-rich proteoglycan (SLRP) family...
- The complete form of X-linked congenital stationary night blindness is caused by mutations in a gene encoding a leucine-rich repeat proteinC M Pusch
Molekulargenetisches Labor, Universitats Augenklinik, Tubingen, Germany
Nat Genet 26:324-7. 2000..This gene, designated NYX, encodes a protein of 481 amino acids (nyctalopin) and is expressed at low levels in tissues including retina, brain, testis and muscle...
- Identification of the gene and the mutation responsible for the mouse nob phenotypeRonald G Gregg
Department of Biochemistry and Molecular Biology, University of Louisville, 319 Abraham Flexner Way, Louisville, KY 40202, USA
Invest Ophthalmol Vis Sci 44:378-84. 2003..b-wave) provides an animal model for the complete form of human X-linked congenital stationary night blindness (CSNB1)...
- Primate Retinal Signaling Pathways: Suppressing ON-Pathway Activity in Monkey With Glutamate Analogues Mimics Human CSNB1-NYX Genetic Night BlindnessNaheed W Khan
National Eye Institute, Bldg 31 Room 6A03, 31 Center Drive, MSC 2510, Bethesda, MD 20892 2110, USA
J Neurophysiol 93:481-92. 2005..CSNB1), a Mendelian genetic condition that results from mutations in the NYX gene encoding the protein nyctalopin. We probed cone pathway dysfunction in four human genotyped CSNB1 affected males by electroretinogram (ERG) ..
- Localization of nyctalopin in the mammalian retinaCatherine W Morgans
Neurological Sciences Institute, Oregon Health and Science University, Beaverton, 97006, USA
Eur J Neurosci 23:1163-71. 2006..The gene responsible for CSNB1, NYX, encodes a novel, leucine-rich repeat protein, nyctalopin. Consistent with its predicted glycosylphosphatidylinositol linkage, we show that recombinant nyctalopin is ..
- CSNB1 in Chinese families associated with novel mutations in NYXXueshan Xiao
Key Laboratory of Ophthalmology of the Ministry of Education and Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 Xianlie Road, Guangzhou, 510060, PR China
J Hum Genet 51:634-40. 2006..Here, two Chinese families with the complete form of CSNB (CSNB1) are presented. Linkage analysis of one family mapped the disease to Xp11-Xq13 where NYX is located...
- Mutations in NYX of individuals with high myopia, but without night blindnessQingjiong Zhang
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
Mol Vis 13:330-6. 2007..Mutations in the nyctalopin gene (NYX) located at Xp11...
- A common NYX mutation in Flemish patients with X linked CSNBB P Leroy
Department of Ophthalmology, Ghent University Hospital, Ghent, Belgium
Br J Ophthalmol 93:692-6. 2009..So far, mutations in two genes, NYX (nyctalopin) and GRM6 (metabotropic glutamate receptor 6) have been associated with this form of CSNB...
- A novel missense mutation in the NYX gene associated with high myopiaShea Ping Yip
Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong SAR, China
Ophthalmic Physiol Opt 33:346-53. 2013Myopia is a complex eye disorder. The X-linked form of complete congenital stationary night blindness (CSNB1A) is usually associated with moderate to high myopia, and is caused by mutations in the NYX gene...
- Mutations in the CACNA1F and NYX genes in British CSNBX familiesIlaria Zito
Division of Molecular Genetics, Institute of Ophthalmology, UCL, London, UK
Hum Mutat 21:169. 2003..Two causative genes (CACNA1F and NYX) for CSNBX have now been identified through positional cloning strategies...
- Novel mutations in CACNA1F and NYX in Dutch families with X-linked congenital stationary night blindnessChristina Zeitz
Division of Medical Molecular Genetics and Gene Diagnostics, Institute of Medical Genetics, University of Zurich, Zurich, Switzerland
Mol Vis 11:179-83. 2005..To describe the clinical features and genetic analysis of eight X-linked congenital stationary night blindness (XLCSNB) Dutch patients...
- Phenotypic expression of the complete type of X-linked congenital stationary night blindness in patients with different mutations in the NYX geneFelix K Jacobi
Molekulargenetisches Labor Universitäts Augenklinik, Tubingen, Germany
Graefes Arch Clin Exp Ophthalmol 240:822-8. 2002To describe the clinical phenotype of the complete type of X-linked congenital stationary night blindness (CSNB1) with different types of mutations in the NYX gene.
- Aland Island eye disease (Forsius-Eriksson syndrome) associated with contiguous deletion syndrome at Xp21. Similarity to incomplete congenital stationary night blindnessR G Weleber
Department of Ophthalmology, Oregon Health Sciences University, Portland 97201
Arch Ophthalmol 107:1170-9. 1989..We also recommend that the gene symbols CSNB1 and CSNB2 be used for complete congenital stationary night blindness and Aland disease, respectively.
- Structural macromolecules and supramolecular organisation of the vitreous gelP N Bishop
Research Group in Eye and Vision Science, The Medical School and Wellcome Trust Centre for Cell Matrix Research, School of Biological Sciences, University of Manchester, UK
Prog Retin Eye Res 19:323-44. 2000....
- Abnormalities of the scotopic threshold response correlated with gene mutation in X-linked retinoschisis and congenital stationary night blindnessKeith Bradshaw
Ophthalmology Department, Addenbrooke s Hospital, Hills Road, Cambridge, UK
Doc Ophthalmol 107:155-64. 2003STRs and dark-adapted ERGs were recorded in nine normal subjects, nine patients with XLRS, 11 patients with CSNB1 and one patient with CSNB2...
- UHX1 and PCTK1: precise characterisation and localisation within a gene-rich region in Xp11.23 and evaluation as candidate genes for retinal diseases mapped to Xp21.1-p11.2O Brandau
Abteilung für Medizinische Genetik, Kinderpoliklinik der Universität, Munchen, Germany
Eur J Hum Genet 6:459-66. 1998..Evaluation of patients revealed no UHX1 mutations using SSCP (10 CSNB1 and 20 XLRP) or deletion screening with cDNA hybridisation (13 CSNB1 and 43 XLRP)...
- Localization of the mouse nob (no b-wave) gene to the centromeric region of the X chromosomeS I Candille
Department of Biochemistry and Molecular Biology, University of Louisville, Kentucky 40202, USA
Invest Ophthalmol Vis Sci 40:2748-51. 1999..To determine the position on the X chromosome of the gene responsible for a spontaneous mouse mutation, nob (no b-wave), which matches the phenotype of complete X-linked congenital stationary night blindness (CSNB) type 1 in human...
- Slow and fast rod ERG pathways in patients with X-linked complete stationary night blindness carrying mutations in the NYX geneH P Scholl
Department of Pathophysiology of Vision and Neuroophthalmology, University Eye Hospital Tubingen, Germany
Invest Ophthalmol Vis Sci 42:2728-36. 2001To study the slow and fast rod signals of the scotopic 15-Hz flicker ERG in patients carrying mutations in the NYX gene, which has been recently identified as the cause of the complete form of congenital stationary night blindness, CSNB1.
- Nyctalopin expression in retinal bipolar cells restores visual function in a mouse model of complete X-linked congenital stationary night blindnessRonald G Gregg
Department of Biochemistry and Molecular Biology, University of Louisville, KY 40202, USA
J Neurophysiol 98:3023-33. 2007Mutations in the NYX gene that encodes the protein nyctalopin cause congenital stationary night blindness type 1...
- Nystagmus characteristics in congenital stationary night blindness (CSNB)C Pieh
University of Freiburg, Department of Ophthalmology, Killianstrasse 5, 79100 Freiburg, Germany
Br J Ophthalmol 92:236-40. 2008..To analyse nystagmus characteristics in patients with congenital stationary night blindness (CSNB) for differentiation from other forms of early childhood nystagmus...
- TRPM1 mutations are associated with the complete form of congenital stationary night blindnessMakoto Nakamura
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan
Mol Vis 16:425-37. 2010..To identify human transient receptor potential cation channel, subfamily M, member 1 (TRPM1) gene mutations in patients with congenital stationary night blindness (CSNB)...
- Complete congenital stationary night blindness maps on Xp11.4 in a Sardinian familyC Rozzo
Istituto di Genetica Molecolare, CNR, Alghero, Italy
Eur J Hum Genet 7:574-8. 1999..retinal disorder, which can appear in two different clinical forms, complete and incomplete, associated with CSNB1 and CSNB2 loci on Xp...
- Mutations in GRM6 cause autosomal recessive congenital stationary night blindness with a distinctive scotopic 15-Hz flicker electroretinogramChristina Zeitz
Division of Medical Molecular Genetics and Gene Diagnostics, Institute of Medical Genetics, University of Zurich, Schwerzenbach, Switzerland
Invest Ophthalmol Vis Sci 46:4328-35. 2005..Mice lacking the metabotropic glutamate receptor 6 (Grm6) have a defect in signal transmission from the photoreceptors to ON-bipolar cells. In the current study, the human orthologue (GRM6) was screened as a likely candidate for arCSNB...
- Isolation and characterization of the leucine-rich proteoglycan nyctalopin gene (cNyx) from chickN Torben Bech-Hansen
Department of Medical Genetics, Population Genomics Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive, N W, Calgary, Alberta, T2N 4N1, Canada
Mamm Genome 16:815-24. 2005We describe the isolation and molecular characterization of the chick ortholog of nyctalopin (NYX), the gene responsible for X-linked complete congenital stationary night blindness (CSNB1, also known as cCSNB)...
- A potential spontaneous rat model of X-linked congenital stationary night blindnessZuoming Zhang
Department of Clinical Aerospace Medicine, The Fourth Military Medical University, Xi an, PR China
Doc Ophthalmol 107:53-7. 2003..To describe a possible spontaneous rat model of X-linked congenital stationary night blindness (CSNB)...
- Congenital stationary night blindness: report of an autosomal recessive family and linkage analysisMarc J Abramowicz
Service de Genetique Medicale, Hôpital Erasme and Laboratoire de Génétique Médicale ULB, Brussels, Belgium
Am J Med Genet A 132:76-9. 2005..CSNB is usually transmitted as a monogenic trait, and most familial cases result from mutations of the NYX gene located on the X chromosome...
- Genotyping microarray for CSNB-associated genesChristina Zeitz
Division of Medical Molecular Genetics and Gene Diagnostics, Institute of Medical Genetics, University of Zurich, Zurich, Switzerland
Invest Ophthalmol Vis Sci 50:5919-26. 2009....
- Recessive mutations of the gene TRPM1 abrogate ON bipolar cell function and cause complete congenital stationary night blindness in humansZheng Li
University College London UCL Institute of Ophthalmology, London EC1V 9EL, UK
Am J Hum Genet 85:711-9. 2009..In humans, mutations in NYX and GRM6 have been shown to cause the condition...
- Differential adherence of osteoarthritis and rheumatoid arthritis synovial fibroblasts to cartilage and bone matrix proteins and its implication for osteoarthritis pathogenesisJ Schedel
Department of Internal Medicine I, Division of Rheumatology and Clinical Immunology, University Hospital of Regensburg, Regensburg, Germany
Scand J Immunol 60:514-23. 2004..g. integrins: collagen/integrin alpha(2)beta(1)) and that higher numbers of OA-SF adhered to the cartilage and bone matrix proteins than did RA-SF...
- Retrospective evaluation of 131I deposition density and thyroid dose in Poland after the Chernobyl accidentZofia Pietrzak-Flis
Central Laboratory for Radiological Protection, Department of Radiation Hygiene, Ul Kowaliowa 7, 03 194 Warsaw, Poland
Health Phys 84:698-708. 2003..doses from 131I were evaluated for 5-y-old children, 10-y-old children, and adults using the computer model CLRP for the situations with and without countermeasures including iodine prophylaxis...
- Molecular characterization and cellular localization of TpLRR, a processed leucine-rich repeat protein of Treponema pallidum, the syphilis spirocheteD V Shevchenko
Department of Internal Medicine, U T Southwestern Medical Center at Dallas, Texas 75235, USA
J Bacteriol 179:3188-95. 1997..The function(s) of TpLRR is currently unknown; however, protein-protein and/or protein-lipid interactions mediated by its LRR motifs may facilitate interactions between components of the T. pallidum cell envelope...
- The C-terminal tail of Yersinia pseudotuberculosis YopM is critical for interacting with RSK1 and for virulenceMelissa W McCoy
Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts 02111, USA
Infect Immun 78:2584-98. 2010..Decreases in NK cells after Y. pseudotuberculosis infection did not correlate with YopM expression. In conclusion, the C terminus of YopM is essential for RSK1 interactions and for virulence...
- Complement inhibitor C4b-binding protein interacts directly with small glycoproteins of the extracellular matrixKaisa E Happonen
Department of Laboratory Medicine, Wallenberg Laboratory, University Hospital Malmo, Lund University, Malmo, Sweden
J Immunol 182:1518-25. 2009....
- FBXL16 is a novel E2F1-regulated gene commonly upregulated in p16INK4A- and p14ARF-silenced HeLa cellsKazuyuki Sato
Department of Life Sciences, Faculty of Agriculture, Meiji University, Tama ku, Kawasaki, Kanagawa 214 8571, Japan
Int J Oncol 36:479-90. 2010..Together, our results illustrate a unique aspect of the interdependence between the p16INK4A/pRb/E2F1 and p14ARF/p53 pathways at a molecular level...
- The CRL2LRR-1 ubiquitin ligase regulates cell cycle progression during C. elegans developmentJorge Merlet
Institut Jacques Monod, CNRS, Universite Paris Diderot, Bâtiment Buffon 15 rue Hélène Brion, 75205 Paris Cedex 13, France
Development 137:3857-66. 2010..Collectively, these observations highlight a crucial function of the CRL2(LRR-1) complex in genome stability via maintenance of DNA replication integrity during C. elegans development...
- Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigenMohammad Alimohammadi
University Hospital, Uppsala University, Uppsala, Sweden
N Engl J Med 358:1018-28. 2008....
- A molecular platform in neurons regulates inflammation after spinal cord injuryJuan Pablo de Rivero Vaccari
Department of Physiology and Biophysics and Neurological Surgery and Miami Project to Cure Paralysis, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
J Neurosci 28:3404-14. 2008..Thus, rat spinal cord neurons contain a caspase-1, pro-ILbeta, and pro-IL-18 activating complex different from the human NALP1 inflammasome that constitutes an important arm of the innate CNS inflammatory response after SCI...
- An evolutionarily conserved leucine-rich repeat protein CLERC is a centrosomal protein required for spindle pole integrityYoshinori Muto
Department of Functional Bioscience, Gifu University School of Medicine, Gifu, Japan
Cell Cycle 7:2738-48. 2008..These data indicate that the major function of CLERC during mitosis is to maintain the structural integrity of centrosomes, thereby contributing to spindle bipolarity...
- TLRR (lrrc67) interacts with PP1 and is associated with a cytoskeletal complex in the testisRong Wang
Department of Anatomy and Cell Biology, Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA
Biol Cell 102:173-89. 2010....
- Phytophthora nicotianae transformants lacking dynein light chain 1 produce non-flagellate zoosporesReena D Narayan
Plant Science Division, Research School of Biology, The Australian National University, Canberra, ACT 2601, Australia
Fungal Genet Biol 47:663-71. 2010..Our observations indicate that zoospore motility is not required for zoospore release from P. nicotianae sporangia or for breakage of the evanescent vesicle into which zoospores are initially discharged...
- A leucine-rich repeat protein is required for growth promotion and enhanced seed production mediated by the endophytic fungus Piriformospora indica in Arabidopsis thalianaBationa Shahollari
Friedrich Schiller Universitat Jena, Institut für Allgemeine Botanik and Pflanzenphysiologie, Dornburger Str 159, 07743 Jena, Germany
Plant J 50:1-13. 2007..indica interaction. Thus, pii-2, and presumably also At5g16590, two proteins present in plasma membrane microdomains, appear to be involved in P. indica-induced growth promotion and enhanced seed production in Arabidopsis thaliana...
- Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifsKatsumi Fukamachi
Experimental Pathology, Chemotherapy Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
J Biol Chem 277:43549-52. 2002..We propose that NLRR-3 potentiates Ras-MAPK signaling by facilitating internalization of EGF in clathrin-coated vesicles...
- The primary structure of a basic leucine-rich repeat protein, PRELP, found in connective tissuesE Bengtsson
Department of Cellular and Molecular Biology, Lund University, Sweden
J Biol Chem 270:25639-44. 1995..Human articular chondrocyte and rat chondrosarcoma cell RNAs contained an additional mRNA of approximately 1.6 and 1.8 kilobases, respectively...
- Structural diversity of leucine-rich repeat proteinsA V Kajava
Swiss Institute for Experimental Cancer Research, Ch des Boveresses 155, s Lausanne, Epalinges, CH 1066, Switzerland
J Mol Biol 277:519-27. 1998..The approach used for the prediction of the leucine-rich repeat protein structures can be applied to other proteins containing internal repeats of about 20 to 30 residue in length...
- Blue-on-yellow perimetry in the complete type of congenital stationary night blindnessH Terasaki
Department of Ophthalmology, Nagoya University School of Medicine, Japan
Invest Ophthalmol Vis Sci 40:2761-4. 1999To resolve the discrepancy between nonrecordable full-field short wavelength cone electroretinograms (S-cone ERGs) and the presence of normal color vision in patients with the complete type of congenital stationary night blindness (CSNB1).
- The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchorEva Bengtsson
Department of Cell and Molecular Biology, Section for Connective Tissue Biology, Lund University, SE 221 84 Lund, Sweden
J Biol Chem 277:15061-8. 2002..Based on the location of PRELP and its interaction with perlecan heparan sulfate chains and collagen, we propose a function of PRELP as a molecule anchoring basement membranes to the underlying connective tissue...
- Protein localization in the human eye and genetic screen of opticinJames S Friedman
Department of Ophthalmology, University of Alberta, Edmonton, AB, Canada T6G 2H7
Hum Mol Genet 11:1333-42. 2002..The protein localization pattern of opticin and our preliminary screen of AMD patients suggest that a larger AMD patient screen may be warranted...
- Large-scale analysis of sequence tags in Xp11.4-11.3 and evaluation of candidate genes for X-linked ocular diseasesC M Pusch
Molecular Genetics Laboratory, University Eye Hospital II, Tubingen, Germany
J Appl Genet 42:89-102. 2001..5 Mb proximal region of the critical region for X-linked congenital stationary night blindness type I (CSNB1) between markers DXS993 and DXS228...
- Aberrant expression and localization of decorin in human oral dysplasia and squamous cell carcinomaAbhijit G Banerjee
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 984525 Nebraska Medical Center, Omaha, NE 68198 4525, USA
Cancer Res 63:7769-76. 2003..Further studies to characterize such interacting proteins and localization-dependent effects of aberrant decorin expressed in oral cancer progression are warranted...
- Constitutive activation of a CC-NB-LRR protein alters morphogenesis through the cytokinin pathway in ArabidopsisKadunari Igari
Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara 630 0192, Japan
Plant J 55:14-27. 2008..From these data, we propose that the modification of the cytokinin pathway might be involved in some R protein-mediated responses...
- Contribution of post-receporal cells to the cone a-wave of the human electroretinogram in congenital stationary night blindness and autoimmune-like retinopathyKeith Bradshaw
Vision Science, Ophthalmology Department, Addenbrooke s Hospital, Cambridge, UK
Vision Res 50:2505-14. 2010..Conversely, the OFF-response was normal in CSNB1 but the a-wave did not increase in the dark...
- cDNA-SRAP and its application in differential gene expression analysis: a case study in Erianthus arundinaceumYouxiong Que
Key Lab of Sugarcane Biology and Genetic Breeding, Ministry of Agriculture, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China
J Biomed Biotechnol 2012:390107. 2012..This study constitutes the first report of genes activated in E. arundinaceum by drought stress and opens up the application of cDNA-SRAP in differential gene expression analysis in E. arundinaceum under certain stress conditions...
- Proline/arginine-rich end leucine-rich repeat protein N-terminus is a novel osteoclast antagonist that counteracts bone lossNadia Rucci
Department of Biotechnological and Applied Clinical Sciences, University of L Aquila, L Aquila, Italy
J Bone Miner Res 28:1912-24. 2013....
- The nucleotide-binding domain and leucine-rich repeat protein-3 inflammasome is not activated in airway smooth muscle upon toll-like receptor-2 ligationJeremy A Hirota
1 University of British Columbia James Hogg Research Centre Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada and
Am J Respir Cell Mol Biol 49:517-24. 2013..Activation of the NLRP3 inflammasome by invading pathogens may prove cell type-specific in exacerbations of airway inflammation in asthma...
- Characterization of the LOV1-mediated, victorin-induced, cell-death response with virus-induced gene silencingBrian M Gilbert
Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR, USA
Mol Plant Microbe Interact 26:903-17. 2013..Silencing the latter four also inhibited cell death and disease resistance mediated by the PTO resistance gene. Together, these results provide evidence that the victorin response mediated by LOV1 is a defense response...
- Assessment of night vision problems in patients with congenital stationary night blindnessMieke M C Bijveld
Bartiméus Institute for the Visually Impaired, Zeist, The Netherlands
PLoS ONE 8:e62927. 2013..CSNB can be subdivided in CSNB2 (rod signal transmission reduced) and CSNB1 (rod signal transmission absent)...
- FKBP51 reciprocally regulates GRα and PPARγ activation via the Akt-p38 pathwayLance A Stechschulte
Center for Diabetes and Endocrine Research L A S, T d H, S S G, S M N, E R S, Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, Ohio 43614 and Herman B Wells Center for Pediatric Research W S, Section of Pediatric Cardiology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202
Mol Endocrinol 28:1254-64. 2014....
- LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site statusApril Reynolds
Parkinson s Institute Sunnyvale, CA, USA
Front Mol Neurosci 7:54. 2014..These findings indicate that comparative analysis of both Ser1292 and Ser910/935/955/973 phosphorylation sites will provide important and distinct measures of LRRK2 kinase and biological activity in vitro and in vivo. ..
- Intracellular fragment of NLRR3 (NLRR3-ICD) stimulates ATRA-dependent neuroblastoma differentiationJesmin Akter
Laboratory of Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba 260 8717, Japan
Biochem Biophys Res Commun 453:86-93. 2014....
- Exploitation of the ability of γ-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitorsRibai Yan
Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, United States
J Med Chem 58:2290-8. 2015..Moreover, 20 was orally active in suppressing xenograft tumor growth in nude mice, which underlines the translational potential of this new class of Akt inhibitor in PTEN-deficient cancers. ..
- Imipramine blue halts head and neck cancer invasion through promoting F-box and leucine-rich repeat protein 14-mediated Twist1 degradationW H Yang
Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
Oncogene 35:2287-98. 2016..Together, this study demonstrates the potent anti-invasion and EMT-inhibition effect of IB, suggesting the potential of IB in treating local invasion-predominant cancers. ..
- The Histone Demethylase FBXL10 Regulates the Proliferation of Spermatogonia and Ensures Long-Term Sustainable Spermatogenesis in MiceManabu Ozawa
Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Biol Reprod 94:92. 2016..These data suggest that Fbxl10 plays important roles in long-term sustainable spermatogenesis via regulating cell cycle. ..
- CO2-responsive polymeric materials: synthesis, self-assembly, and functional applicationsAli Darabi
Department of Chemical Engineering, Queen s University, Kingston, Canada
Chem Soc Rev 45:4391-436. 2016..reversible deactivation radical polymerization (RDRP), formerly known as controlled/living radical polymerization (CLRP), a powerful technique for the preparation of well-defined (co)polymers with precise control over molecular weight ..
- FBXL5 attenuates RhoGDI2-induced cisplatin resistance in gastric cancer cellsW D Wu
Department of Gastrointestinal Surgery, and 2Department of Oncology Shanghai General Hospital of Nanjing Medical University, Shanghai, China
Eur Rev Med Pharmacol Sci 20:2551-7. 2016....
- Revision of the genus Allometopon Kertész (Diptera: Clusiidae)Owen Lonsdale
Agriculture and Agri Food Canada, 960 Carling Avenue, Ottawa, Ontario, K1A 0C6, Canada Email
Zootaxa 4106:1-127. 2016..infernum, A. juxtum, A. kokodensis, A. lunatum, A. lux, A. macalpinei, A. machaeroges, A. magnum, A. monstrum, A. nyx, A. phenomena, A. philomela, A. platystylum, A. plicatum, A. procne, A. selenis, A. solare, A. suspirium, A...
- Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through Inhibiting NLRP3 Inflammasome in MacrophagesPing Ke
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, China
PLoS ONE 11:e0155076. 2016..We conclude that activation of CB2R ameliorates DSS-induced colitis through enhancing autophagy that may inhibit NLRP3 inflammasome activation in macrophages. ..
- Protective effect of gedunin on TLR-mediated inflammation by modulation of inflammasome activation and cytokine production: Evidence of a multitarget compoundPerla Villani Borges
Laboratório de Farmacologia Aplicada, Farmanguinhos, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
Pharmacol Res 115:65-77. 2016..Overall, our data demonstrate that gedunin modulates TLR4, TLR3 and TLR2-mediated responses and reveal new molecular targets for this compound...
- miR-3117 regulates hepatocellular carcinoma cell proliferation by targeting PHLPPLXia Cui
Department of Hepatopathy, Liaocheng People s Hospital, 67 Dongchang West Road, Liaocheng, 252000, China
Mol Cell Biochem 424:195-201. 2017..Double knockdown of miR-3117 and PHLPPL copied the phenotypes caused by miR-3117 overexpression, suggesting that miR-3117 contributes to the proliferation of HepG2 by targeting PHLPPL. Our study provided a target for HCC therapy...
- Single Locus Maintains Large Variation of Sex Reversal in Half-Smooth Tongue Sole (Cynoglossus semilaevis)Li Jiang
Chinese Academy of Fishery Sciences
G3 (Bethesda) . 2016..This SNP is located at the third intron of the F-box and leucine rich repeat protein 17 (FBXL17) gene on the Z chromosome, it has two alleles, A and T...
- NALP1 in vitiligo-associated multiple autoimmune diseaseYing Jin
Human Medical Genetics Program, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
N Engl J Med 356:1216-25. 2007..The group includes various combinations of generalized vitiligo, autoimmune thyroid disease, latent autoimmune diabetes in adults, rheumatoid arthritis, psoriasis, pernicious anemia, systemic lupus erythematosus, and Addison's disease...
- An avirulent tomato powdery mildew isolate induces localized acquired resistance to a virulent isolate in a spatiotemporal mannerAlireza Seifi
Wageningen UR Plant Breeding, Wageningen University and Research Center, Droevendaalsesteeg, The Netherlands
Mol Plant Microbe Interact 25:372-8. 2012..Altogether, we report an advanced technique for investigating LAR phenomena, and provide data on spatiotemporal characteristics of LAR in tomato epidermal cells...
- NF-κB1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1Y Yu
1 Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, NY, USA 2 Oversea Laboratory, Center for Medical Research, Wuhan University, Wuhan, Hubei, China
Oncogene 33:996-1005. 2014..Collectively, we have identified a novel function of p50 in modulating p53 protein translation via regulation of the miR-190/PHLPP1/Akt-S6 ribosomal protein pathway. ..
- The EGP1 gene may be a positive regulator of protein phosphatase type 1 in the growth control of Saccharomyces cerevisiaeN Hisamoto
Department of Molecular Biology, Faculty of Science, Nagoya University, Japan
Mol Cell Biol 15:3767-76. 1995..Egp1 and PP1 directly interact, as assayed by coimmunoprecipitation. These results suggest that Egp1 functions as a positive modulator of PP1 in the growth control of S. cerevisiae...
- Sequence and expression of LRR47, a novel embryonic leucine rich repeat protein of DrosophilaM Ntwasa
Department of Biochemistry, University of Cambridge, UK
Biochim Biophys Acta 1218:181-6. 1994..The LRR47 gene maps to position 32A on the left arm of chromosome 2, an interval in which three genes with semi-lethal maternal effects (dal, hup and wdl) are located...
- Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolutionA C Papageorgiou
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
EMBO J 16:5162-77. 1997..The implications of these findings for the development of small, hRI-based inhibitors of Ang for therapeutic use are discussed...
- Isolation of a novel iris-specific and leucine-rich repeat protein (oculoglycan) using differential selectionJ S Friedman
Department of Ophthalmology, University of Alberta, Edmonton, Canada
Invest Ophthalmol Vis Sci 41:2059-66. 2000..To identify and characterize genes expressed in the iris...
- Fliih, the murine homologue of the Drosophila melanogaster flightless I gene: nucleotide sequence, chromosomal mapping and overlap with LlglhH D Campbell
Centre for Molecular Structure and Function, Research School of Biological Sciences, John Curtin School of Medical Research, The Australian National University, Canberra, ACT
DNA Seq 11:29-40. 2000..The overlap region contains polyA signals for both genes and is conserved between human and mouse...
- Differential expression of lumican and fibromodulin regulate collagen fibrillogenesis in developing mouse tendonsY Ezura
Department of Pathology Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
J Cell Biol 151:779-88. 2000..These studies indicate that lumican and fibromodulin have different developmental stage and leucine-rich repeat protein specific functions in the regulation of fibrillogenesis...
- Infantile and childhood retinal blindness: a molecular perspective (The Franceschetti Lecture)Richard G Weleber
Casey Eye Institute, Oregon Health and Science University, Portland, OR 97201 4197, USA
Ophthalmic Genet 23:71-97. 2002..CNGB3), X-linked congenital stationary night blindness (CSNB) from mutations of CACNA1F (incomplete CSNB) and NYX (complete CSNB), and the enhanced S-cone syndrome from mutation of the developmental gene, NR2E3 at 15q23, which ..
- LeSTIG1, an extracellular binding partner for the pollen receptor kinases LePRK1 and LePRK2, promotes pollen tube growth in vitroWeihua Tang
Plant Gene Expression Center, United States Department of Agriculture Agricultural Research Service, and Department of Plant and Microbial Biology, University of California at Berkeley, 800 Buchanan Street, Albany, CA 94710, USA
Plant J 39:343-53. 2004..Exogenous LeSTIG1 promotes pollen tube growth in vitro. The interaction of these pollen kinases with LeSTIG1 supports the notion that LePRK1 and LePRK2 are involved in mediating pollen-pistil interactions...
- Tannerella forsythia-induced alveolar bone loss in mice involves leucine-rich-repeat BspA proteinA Sharma
Department of Oral Biology, School of Dental Medicine, State University of New York, 3435 Main Street, Buffalo, NY 14214, USA
J Dent Res 84:462-7. 2005..In conclusion, evidence is presented in support of T. forsythia as an important organism involved in inducing alveolar bone loss, and the BspA protein is an important virulence factor of this bacterium...
- The Anp32 family of proteins containing leucine-rich repeatsAntoni Matilla
Institute of Child Health, University College London, London, UK
Cerebellum 4:7-18. 2005....
- Identification of a novel antigen of Schistosoma mansoni shared with Plasmodium falciparum and evaluation of different cross-reactive antibody subclasses induced by human schistosomiasis and malariaChristine Pierrot
Unité INSERM 547, IFR 17, Institut Pasteur de Lille, 1 rue du Prof Calmette, 59019 Lille, France
Infect Immun 74:3347-54. 2006..In addition, the levels of anti-SmLRR IgG4, but not the levels of IgG3, correlated positively with the intensity of S. mansoni infection...
- Bacterial killing by heparin-binding peptides from PRELP and thrombospondinMartin Malmsten
Department of Pharmacy, Uppsala University, SE 751 23 Uppsala, Sweden
Matrix Biol 25:294-300. 2006..Thus, the data disclose a novel antimicrobial activity of heparin-binding regions of matrix glycoproteins. The findings can be utilized in the development of novel AMPs for therapeutic use...
- Nephrocan, a novel member of the small leucine-rich repeat protein family, is an inhibitor of transforming growth factor-beta signalingYoshiyuki Mochida
Dental Research Center, University of North Carolina, Chapel Hill, North Carolina 27599 7455, USA
J Biol Chem 281:36044-51. 2006..Taken together, NPN is a novel member of the SLRP family that may play important roles in kidney development and pathophysiology by functioning as an endogenous inhibitor of TGF-beta signaling...
- Thioredoxin h5 is required for victorin sensitivity mediated by a CC-NBS-LRR gene in ArabidopsisTeresa A Sweat
Department of Botany and Plant Pathology, Center for Genome Research and Biocomputing, Oregon State University, Corvallis, Oregon 97331 2902, USA
Plant Cell 19:673-87. 2007..Finally, we determined that only the first of the two active-site Cys residues in ATTRX5 is required for the response to victorin, suggesting that ATTRX5 function in the victorin pathway involves an atypical mechanism of action...
- The Arabidopsis gain-of-function mutant ssi4 requires RAR1 and SGT1b differentially for defense activation and morphological alterationsFasong Zhou
Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, NY 14853, USA
Mol Plant Microbe Interact 21:40-9. 2008..Thus, multiple environmental factors impact on ssi4 signaling, as has been observed for other constitutive defense mutants and R gene-triggered pathways...
- Benchmarking EGSnrc in the kilovoltage energy range against experimental measurements of charged particle backscatter coefficientsE S M Ali
Carleton Laboratory for Radiotherapy Physics, Ottawa Carleton Institute of Physics, Carleton University, 1125 Colonel By Drive, Ottawa, ON K1S 5B6, Canada
Phys Med Biol 53:1527-43. 2008..A documented EGSnrc user-code customized for backscatter calculations is available from the authors at http://www.physics.carleton.ca/clrp/backscatter.
- Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoformsIsao Hirano
Department of Internal Medicine III, Cancer Center, Hamamatsu University School of Medicine, Shizuoka, Japan
J Biol Chem 284:22155-65. 2009..Thus, Bcr-Abl represses the expression of PHLPP1 and PHLPP2 and continuously activates Akt1, -2, and -3 via phosphorylation on Ser-473, resulting in the proliferation of CML cells...
- Leucine-rich repeat protein complex activates mosquito complement in defense against Plasmodium parasitesMichael Povelones
Division of Cell and Molecular Biology, Department of Life Sciences, Imperial College London, Exhibition Road, London SW7 2AZ, UK
Science 324:258-61. 2009..LRIM1 and APL1C are members of a protein family with orthologs in other disease vector mosquitoes and appear to be important effectors in innate mosquito defenses against human pathogens...
- PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatumA Saavedra
Departament de Biologia Cellular, Immunologia i Neurociencies, Facultat de Medicina, Universitat de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Casanova 143, Barcelona, Spain
Cell Death Differ 17:324-35. 2010..In the striatum, these reduced levels of PHLPP1 can contribute to maintain high levels of activated Akt that may delay cell death and allow the recovery of neuronal viability after mutant huntingtin silencing...
- Nightblindness-associated transient tonic downgaze (NATTD) in infant boys with chin-up head postureH J Simonsz
Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience, Amsterdam
Strabismus 17:158-64. 2009..Eight boys had CACNA1F mutations, and 1 boy had a NYX mutation, compatible with incomplete or complete congenital stationary nightblindness (iCSNB or cCSNB), ..
- A role for nyctalopin, a small leucine-rich repeat protein, in localizing the TRP melastatin 1 channel to retinal depolarizing bipolar cell dendritesJillian N Pearring
Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, Kentucky 40202, USA
J Neurosci 31:10060-6. 2011..We report that the extracellular membrane-attached protein nyctalopin is required for the normal expression of TRPM1 on the dendrites of DBCs in mus musculus...
- Diacylglycerol kinase δ modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2)Tracy M Crotty
Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
J Biol Chem 288:1439-47. 2013..Our collective data indicate that DGKδ is a pertinent cancer target, and our studies could lay the groundwork for development of novel cancer therapeutics...
- Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheromaRandolph Hutter
Departments of Medicine and Cardiology, Mount Sinai School of Medicine, New York, NY R H, L H, W S S, C G, P T, V F, J J B Department of Cardiology, Elisabeth Klinikum, Schmalkalden, Germany G B Department of Medicine, Duke University, Durham, NC M E K and Department of Medicine, Baylor College of Medicine, Houston, TX P E K
Circulation 128:2351-63. 2013..In all these conditions, we concomitantly evaluated the Wnt-TCF (T-cell factor) pathway...
- AAV-mediated expression of human PRELP inhibits complement activation, choroidal neovascularization and deposition of membrane attack complex in miceM T Birke
Department of Ophthalmology, Tufts University School of Medicine, Boston, MA, USA
Gene Ther 21:507-13. 2014..PRELP reduced deposition of MAC in vivo by 25.5%. Our results have implications for the development of complement inhibitors as a therapy for AMD...
- Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3β/Fyn kinase axis during oxidative hepatocellular toxicityF Rizvi
1 Academy of Scientific and Innovative Research, New Delhi, India 2 Herbal Research Section, Food Drug and Chemical Toxicology Division, Council of Scientific and Industrial Research Indian Institute of Toxicology Research CSIR IITR, Lucknow, India
Cell Death Dis 5:e1153. 2014..The study indicates that PHLPP2 could serve as a new target for developing strategies to manage pathological conditions exacerbated due to oxidative stress. ..
- Refractive index measurement of the mouse crystalline lens using optical coherence tomographyRanjay Chakraborty
Department of Ophthalmology, Emory University School of Medicine, 1365B Clifton Rd NE Atlanta, GA 30322, USA Center of Excellence in Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 1670 Clairmont Road, Decatur, GA 30033, USA
Exp Eye Res 125:62-70. 2014..in thickness and refractive index of the mouse crystalline lens for two different strains, wild-type (WT) and a nyx mutant (nob) over the course of normal visual development or after form deprivation...
- Investigation of genetic variants in ubiquitin enzyme genes involved in the modulation of neurodevelopmental processes: a role in schizophrenia susceptibility?Jessica L Andrews
Centre for Translational Neuroscience, Illawarra Health and Medical Research Institute, Faculty of Science, Medicine and Health, University of Wollongong, New South Wales 2522, Australia
Genet Res (Camb) 96:e15. 2014..Regarding the rising interest in ubiquitin-related proteins as a therapeutic target in other pathologies such as cancer, further research into the role of ubiquitin pathways in schizophrenia seems topical and timely...
- Artificial Recruitment of UAF1-USP Complexes by a PHLPP1-E1 Chimeric Helicase Enhances Human Papillomavirus DNA ReplicationDavid Gagnon
Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec, Canada Department of Biochemistry and Molecular Medicine, Universite de Montreal, Montreal, Quebec, Canada
J Virol 89:6227-39. 2015....
- Mouse Model of DBC DysfunctionNeal S Peachey; Fiscal Year: 2012..by defects in depolarizing bipolar cell (DBC) signal transduction and in patients has been linked to mutations in NYX, GRM6 or TRPM1...
- Maureen A McCall; Fiscal Year: 2014..We have three unique mouse models of CSNB1 that we will continue to use to probe the synaptic circuitry underlying CSNB, in which normal photoreceptor ..
- Ronald G Gregg; Fiscal Year: 2016..Mutations in GRM6, NYX, TRPM1 and GPR179 cause cCSNB. The mechanism by which mGluR6 signals TRPM1 is largely unknown...
- Mechanisms for regulation of cell adhesion and migrationJulie L Kadrmas; Fiscal Year: 2013..abstract_text> ..
- JULIE ERIKA M HAYDU; Fiscal Year: 2015..Overall, these studies will characterize the roles and mechanisms of FBXL4 in the pathogenesis of T-ALL. ..
- COLLEEN ANN SWEENEY; Fiscal Year: 2016..In Aim 2, we will examine the role of Lrig1 in crosstalk between the estrogen receptor-a and ErbB2 with implications for endocrine resistance. ..
- Alexandra C Newton; Fiscal Year: 2014..In addition, we will address the roles of PHLPP1 and PHLPP2 in prostate cancer using a mouse model and in breast cell growth using a 3D culture model. ..
- LEUCINE-RICH REPEAT PROTEIN LRRc17 AND OSTEOCLASTSYongwon Choi; Fiscal Year: 2009....
- Zebrafish Mutant Mapping FacilityRonald Gregg; Fiscal Year: 2007..unreadable] [unreadable]..
- PROTEIN KINASE C AND PHOTORECEPTORSALEXANDRA NEWTON; Fiscal Year: 2002..Specifically, the effect of this phosphorylation on rhodopsin s macromolecular interactions (transducin coupling, arrestin binding) will be explored. ..
- MOLECULAR GENETIC ANALYSIS OF S. MUTANS CARIOGENICITYAshu Sharma; Fiscal Year: 2004..The specific aims of this proposal are designed to provide new information regarding essential virulence factors of S. mutans which could be exploited to design novel anticaries strategies. ..
- Oral spirochetes: molecular genetic analysisAshu Sharma; Fiscal Year: 2004..pallidum, may play a role in periodontitis will be examined. These approaches should increase understanding of the molecular basis for the pathogenicity of spirochetes. ..
- Genetic Control of Schwann Cell DifferentiationJOHN RUTLEDGE BERMINGHAM; Fiscal Year: 2011..By understanding how the Lgi4 protein controls Schwann cell development, we will establish new avenues for the treatment of myelin disorders and nerve injury. ..
- The role of nyctalopin in the mammalian retinaCATHERINE MORGANS; Fiscal Year: 2006..The human gene responsible for CSNB1, NYX, encodes a novel protein, nyctalopin, belonging to the family of leucine rich repeat (LRR) proteins...
- Calcium channels at ribbon synapses in the retinaCATHERINE MORGANS; Fiscal Year: 2008..The results of these experiments will provide insight into the composition and functional organization of retinal ribbon synapses and into the perturbation of retinal function associated with CSNB2. ..