NUDEL

Summary

Gene Symbol: NUDEL
Description: nudE neurodevelopment protein 1 like 1
Alias: EOPA, MITAP1, NDE1L1, NDE2, NUDEL, nuclear distribution protein nudE-like 1, endooligopeptidase A, mitosin-associated protein 1, mitosin-associated protein MITAP1, nudE nuclear distribution E homolog-like 1, nudE nuclear distribution gene E homolog-like 1, protein Nudel
Species: human

Top Publications

  1. pmc Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3
    Carlos Cardoso
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Am J Hum Genet 72:918-30. 2003
  2. pmc The LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein
    V P Efimov
    University of Medicine and Dentistry or New Jersey, Robert Wood Johnson Medical School, Department of Pharmacology, 675 Hoes Lane, Piscataway, New Jersey 08854 5635, USA
    J Cell Biol 150:681-8. 2000
  3. ncbi LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome
    Y Feng
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Neuron 28:665-79. 2000
  4. ncbi A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system
    S Sasaki
    Shirakawa Institute of Animal Genetics, Odakura Nishigo Nishishirakawa, 961 8061, Fukushima, Japan
    Neuron 28:681-96. 2000
  5. ncbi NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein
    M Niethammer
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachussetts 02115, USA
    Neuron 28:697-711. 2000
  6. pmc Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth
    Yuji Ozeki
    Division of Neurobiology and Department of Psychiatry, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 100:289-94. 2003
  7. pmc Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle
    Xiumin Yan
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Mol Cell Biol 23:1239-50. 2003
  8. ncbi 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome
    Kazuhito Toyo-oka
    Department of Pediatrics, UCSD Cancer Center, University of California, San Diego School of Medicine, 9500 Gilman Drive, Mailstop 0627, La Jolla, California 92093 0627, USA
    Nat Genet 34:274-85. 2003
  9. ncbi DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation
    Jill A Morris
    Department of Neuroscience, Merck Research Laboratories, West Point, PA 19486, USA
    Hum Mol Genet 12:1591-608. 2003
  10. ncbi Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders
    N J Brandon
    Merck Sharp and Dohme, The Neuroscience Research Centre, Harlow, Essex, CM20 2QR, UK
    Mol Cell Neurosci 25:42-55. 2004

Research Grants

  1. Role of neuronal migration genes in synaptogenesis and plasticity
    Anamaria Sudarov; Fiscal Year: 2013
  2. Atsushi Kamiya; Fiscal Year: 2014
  3. Terry H Lechler; Fiscal Year: 2016
  4. Deanna S Smith; Fiscal Year: 2016
  5. Spatial Control of Proteolysis in Dorsoventral Polarity
    ELLEN LEMOSY; Fiscal Year: 2009
  6. Akira Sawa; Fiscal Year: 2016
  7. Steven P Gross; Fiscal Year: 2014
  8. Yixian Zheng; Fiscal Year: 2014
  9. SIGNAL TRANSDUCTION PATHWAY MEDIATING CDK5 FUNCTION
    Li Huei Tsai; Fiscal Year: 2006
  10. Genetic Analysis of LIS1 Function in the Mouse
    Anthony Wynshaw Boris; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications133 found, 100 shown here

  1. pmc Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3
    Carlos Cardoso
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Am J Hum Genet 72:918-30. 2003
    ....
  2. pmc The LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein
    V P Efimov
    University of Medicine and Dentistry or New Jersey, Robert Wood Johnson Medical School, Department of Pharmacology, 675 Hoes Lane, Piscataway, New Jersey 08854 5635, USA
    J Cell Biol 150:681-8. 2000
    ..In addition, NUDF coprecipitates with an epitope-tagged NUDE. The fact that NUDF and LIS1 interact with the same protein domain strengthens the notion that these two proteins are functionally related...
  3. ncbi LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome
    Y Feng
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Neuron 28:665-79. 2000
    ..Moreover, misexpression of the LIS1 binding domain of mNudE in Xenopus embryos disrupts the architecture and lamination of the CNS. Thus, LIS1-mNudE interactions may regulate neuronal migration through dynamic reorganization of the MTOC...
  4. ncbi A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system
    S Sasaki
    Shirakawa Institute of Animal Genetics, Odakura Nishigo Nishishirakawa, 961 8061, Fukushima, Japan
    Neuron 28:681-96. 2000
    ..Here, we demonstrate that LIS1 directly interacts with the cytoplasmic dynein heavy chain (CDHC) and NUDEL, a murine homolog of the Aspergillus nidulans nuclear migration mutant NudE...
  5. ncbi NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein
    M Niethammer
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachussetts 02115, USA
    Neuron 28:697-711. 2000
    ..Recently, we demonstrated that mammalian LIS1 regulates dynein functions. Here we characterize NUDEL, a novel LIS1-interacting protein with sequence homology to gene products also implicated in nuclear distribution ..
  6. pmc Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth
    Yuji Ozeki
    Division of Neurobiology and Department of Psychiatry, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 100:289-94. 2003
    ..In yeast two-hybrid analyses, DISC-1 interacts with a variety of cytoskeletal proteins. One of these, NudE-like (NUDEL), is associated with cortical development and is linked to LIS-1, the disease gene for a form of lissencephaly, a ..
  7. pmc Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle
    Xiumin Yan
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Mol Cell Biol 23:1239-50. 2003
    Emerging evidence supports the idea that a signaling pathway containing orthologs of at least mammalian NudE and Nudel, Lis1, and cytoplasmic dynein is conserved for eukaryotic nuclear migration...
  8. ncbi 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome
    Kazuhito Toyo-oka
    Department of Pediatrics, UCSD Cancer Center, University of California, San Diego School of Medicine, 9500 Gilman Drive, Mailstop 0627, La Jolla, California 92093 0627, USA
    Nat Genet 34:274-85. 2003
    ..14-3-3epsilon binds to CDK5/p35-phosphorylated NUDEL and this binding maintains NUDEL phosphorylation...
  9. ncbi DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation
    Jill A Morris
    Department of Neuroscience, Merck Research Laboratories, West Point, PA 19486, USA
    Hum Mol Genet 12:1591-608. 2003
    ..assays with multiple proteins of the centrosome and cytoskeletal system, including MIPT3, MAP1A and NUDEL; proteins which localize receptors to membranes, including alpha-actinin2 and beta4-spectrin; and proteins which ..
  10. ncbi Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders
    N J Brandon
    Merck Sharp and Dohme, The Neuroscience Research Centre, Harlow, Essex, CM20 2QR, UK
    Mol Cell Neurosci 25:42-55. 2004
    ..We have demonstrated that DISC1 exists in a neurodevelopmentally regulated protein complex with Nudel. The complex is abundant at E17 and in early postnatal life but is greatly reduced in the adult...
  11. pmc Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein
    Yun Liang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    J Cell Biol 164:557-66. 2004
    b>Nudel and Lis1 appear to regulate cytoplasmic dynein in neuronal migration and mitosis through direct interactions. However, whether or not they regulate other functions of dynein remains elusive...
  12. ncbi Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase
    Cataldo Tarricone
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Neuron 44:809-21. 2004
    ..LIS1 binds dynein and the dynein-associated proteins Nde1 (formerly known as NudE), Ndel1 (formerly known as NUDEL), and CLIP-170, as well as the catalytic alpha dimers of brain cytosolic platelet activating factor ..
  13. pmc Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1
    Mirian A F Hayashi
    Center for Applied Toxinology, Laboratories of Immunogenetics and Immunochemistry, Butantan Institute, and Laboratory of Neurosciences, Universidade Cidade de São Paulo, SP 05503 900, Sao Paulo, Brazil
    Proc Natl Acad Sci U S A 102:3828-33. 2005
    ..Interestingly, NUDEL is the same protein as endooligopeptidase A (EOPA), a thiol-activated peptidase involved in conversion and inactivation of a number of bioactive ..
  14. ncbi Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration
    Kazuhito Toyo-oka
    Department of Genetic Disease Research, Osaka University Graduate School of Medicine, Japan
    Hum Mol Genet 14:3113-28. 2005
    LIS1 is mutated in the human neuronal migration defect lissencephaly and along with NDEL1 (formerly NUDEL) participates in the regulation of cytoplasmic dynein function during neuronal development...
  15. pmc Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly
    Jing Guo
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, Shanghai 200031, China
    Mol Biol Cell 17:680-9. 2006
    ..The centrosome is the major microtubule-organizing center in animal cells. Although the cytoplasmic dynein regulator Nudel interacts with centrosomes, its role herein remains unclear...
  16. ncbi Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation
    Y Hirohashi
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Oncogene 25:6048-55. 2006
    ..Collectively, our findings indicate that Nde1 can form a protein complex with Su48 in the centrosome and plays an important role for successful mitosis...
  17. ncbi DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1
    Atsushi Kamiya
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Hum Mol Genet 15:3313-23. 2006
    ..Here, we show that a specific interaction between DISC1 and nuclear distribution element-like (NDEL1/NUDEL) is required for neurite outgrowth in differentiating PC12 cells...
  18. ncbi Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia
    L M Camargo
    Merck Research Labs, Merck and Co, Boston, MA 02115, USA
    Mol Psychiatry 12:74-86. 2007
    ....
  19. pmc Nudel modulates kinetochore association and function of cytoplasmic dynein in M phase
    Yun Liang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Mol Biol Cell 18:2656-66. 2007
    ..Regulation of such diverse functions, however, is poorly understood. We have previously shown that Nudel is critical for dynein-mediated protein transport, whereas mitosin, a kinetochore protein that binds Nudel, is ..
  20. ncbi Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes
    Mailys A S Vergnolle
    Faculty of Life Sciences, Michael Smith Building, Oxford Road, University of Manchester, Manchester, UK
    Curr Biol 17:1173-9. 2007
    ..A major function of Cenp-F, therefore, is to link the Ndel1/Nde1/Lis1/Dynein pathway to kinetochores. Furthermore, our data demonstrate that Ndel1 and Nde1 play distinct roles to ensure chromosome alignment and segregation...
  21. doi Insolubility of disrupted-in-schizophrenia 1 disrupts oligomer-dependent interactions with nuclear distribution element 1 and is associated with sporadic mental disease
    S Rutger Leliveld
    Department of Neuropathology, Heinrich Heine University of Dusseldorf, 40225 Dusseldorf, Germany
    J Neurosci 28:3839-45. 2008
    ..We conclude that the absence of oligomer-dependent ligand interactions of DISC1 can be associated with sporadic mental disease of mixed phenotypes...
  22. pmc Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding
    Katherine E Burdick
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Hum Mol Genet 17:2462-73. 2008
    ..These data suggest that NDEL1 significantly influences risk for SZ via an interaction with DISC1. We propose a model where NDEL1 and NDE1 compete for binding with DISC1...
  23. pmc LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein
    Masami Yamada
    Department of Genetic Disease Research, Osaka City University Graduate School of Medicine, Osaka, Japan
    EMBO J 27:2471-83. 2008
    ....
  24. doi Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA)
    Daniel M Collins
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, Wolfson Link and Davidson Buildings, University of Glasgow, University Avenue, Glasgow, G12 8QQ, Scotland, UK
    Cell Signal 20:2356-69. 2008
    The involvement of the Nuclear distribution element-like (Ndel1; Nudel) protein in the recruitment of the dynein complex is critical for neurodevelopment and potentially important for neuronal disease states...
  25. pmc Requirement for Nudel and dynein for assembly of the lamin B spindle matrix
    Li Ma
    Laboratory of Molecular Cell Biology and Center of Cell Signaling, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Nat Cell Biol 11:247-56. 2009
    ..Here we report that the isolated matrix contains known spindle assembly factors such as dynein and Nudel. Using spindle assembly assays in Xenopus egg extracts, we show that Nudel regulates microtubule organization ..
  26. pmc Nudel and FAK as antagonizing strength modulators of nascent adhesions through paxillin
    Yongli Shan
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS Biol 7:e1000116. 2009
    ..Here, we show that Nudel knockdown by interference RNA (RNAi) resulted in cell edge shrinkage due to poor adhesions of membrane protrusions...
  27. pmc Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity
    Anat Shmueli
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    EMBO J 29:107-19. 2010
    ..Our findings indicate, to the best of our knowledge, for the first time that Ndel1 palmitoylation is a new mean for fine-tuning the activity of the retrograde motor cytoplasmic dynein...
  28. doi Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning
    Connie Lam
    Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK
    J Cell Sci 123:202-12. 2010
    ..Consistent with this hypothesis, expression of exogenous NDE1 or NDEL1 rescued the effects of LIS1 depletion on Golgi organisation, whereas LIS1 was only partially effective at rescuing the loss of NDE1 and NDEL1...
  29. doi Ndel1, Nudel (Noodle): flexible in the cell?
    Mathieu Chansard
    Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Alberta, Canada
    Cytoskeleton (Hoboken) 68:540-54. 2011
    Nuclear distribution element-like 1 (Ndel1 or Nudel) was firstly described as a regulator of the cytoskeleton in microtubule and intermediate filament dynamics and microtubule-based transport...
  30. pmc Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly
    Saravanakumar Narayanan
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 286:44266-76. 2011
    ..These results suggest that the improper oligomeric assembly of DISC1-S704C may underlie the observed phenotypic variation due to the polymorphism...
  31. pmc NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment
    Daisuke Mori
    Osaka City University Graduate School of Medicine, Genetic Disease Research, Asahi machi 1 4 3 Abeno, Osaka 545 8586, Japan
    Mol Cell Biol 27:352-67. 2007
    ..Our findings suggest that Aurora-A-mediated phosphorylation of NDEL1 is essential for centrosomal separation and centrosomal maturation and for mitotic entry...
  32. ncbi The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly
    Urszula Derewenda
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    Structure 15:1467-81. 2007
    ....
  33. pmc Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin
    Young Un Park
    Division of Molecular and Life Science, Department of Life Science, Biotechnology Research Center, Pohang University of Science and Technology, Pohang 790 784, Korea
    Proc Natl Acad Sci U S A 107:17785-90. 2010
    ..According to these results, we propose that DISC1 plays essential roles for mitochondrial function in collaboration with a mitochondrial interacting partner, Mitofilin...
  34. ncbi On simple repetitive DNA sequences and complex diseases
    C Epplen
    Ruhr University Bochum, Germany
    Electrophoresis 18:1577-85. 1997
    ..diseases multiple sclerosis (MS), rheumatoid arthritis (RA) and early onset pauciarticular arthritis (EOPA)...
  35. ncbi Endooligopeptidase A activity in rabbit heart: generation of enkephalin from enkephalin containing peptides
    M A Cicilini
    Department of Physiological Sciences, Universidade Federal do Espirito Santo, ES, Brazil
    Peptides 9:945-55. 1988
    ..These two enzymes share several properties with the previously described rabbit brain endooligopeptidase A. They were shown to produce, by a single peptide bond cleavage, [Met5] enkephalin and [Leu5]enkephalin from ..
  36. doi The kappa immunoglobulin light chain repertoire of peripheral blood B cells in patients with juvenile rheumatoid arthritis
    Henner Morbach
    Pediatric Rheumatology, Immunology and Infectious Diseases, Children s Hospital, University of Wurzburg, Germany
    Mol Immunol 45:3840-6. 2008
    ..changes in the immunoglobulin light chain repertoire might exist in early-onset pauciarticular arthritis (EOPA) patients thereby potentially revealing distinct molecular patterns, which characterize defects in central ..
  37. doi Long-term culture of mouse embryonic stem cell-derived adherent neurospheres and functional neurons
    Mirian A F Hayashi
    Departamento de Farmacologia, Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, SP, Brazil
    Tissue Eng Part C Methods 16:1493-502. 2010
    ....
  38. pmc Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice
    Yong Ha Youn
    Department of Pediatrics, Institute for Human Genetics, University of California, San Francisco School of Medicine, San Francisco, California 94143 0794, USA
    J Neurosci 29:15520-30. 2009
    ..Thus, Lis1 and Ndel1 are essential for normal cortical neuronal migration, neurite outgrowth, and function of the MTOC in a dose-dependent manner...
  39. ncbi A distinct HLA-DRw8 haplotype characterizes patients with juvenile rheumatoid arthritis
    C Van Kerckhove
    Children s Hospital Medical Center, Cincinnati, OH
    Immunogenetics 32:304-8. 1990
    ..loci of 67 HLA-DRw8-positive Caucasians including 43 with early-onset pauciarticular juvenile rheumatoid arthritis (EOPA-JRA, alternatively known as early-onset pauciarticular juvenile chronic arthritis)...
  40. ncbi DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1
    Shinichiro Taya
    Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa, Nagoya 466 8550, Japan
    J Neurosci 27:15-26. 2007
    ..DISC1 is reported to interact with NudE-like (NUDEL), which forms a complex with lissencephaly-1 (LIS1) and 14-3-3epsilon...
  41. pmc Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality
    Shinji Sasaki
    Department of Neuro science, Research Center for Genomic Medicine, Saitama Medical School, Japan
    Mol Cell Biol 25:7812-27. 2005
    ....
  42. ncbi Physical performance and school physical education in overweight Spanish children
    José A Casajús
    Facultad de Ciencias de la Salud y del Deporte, Universidad de Zaragoza, Zaragoza, Spain
    Ann Nutr Metab 51:288-96. 2007
    To evaluate the effect of physical performance and extracurricular organized physical activities (EOPA) in normal- and overweight children.
  43. ncbi Structural analysis of multiprotein complexes by cross-linking, mass spectrometry, and database searching
    Alessio Maiolica
    FIRC Institute of Molecular Oncology Foundation, Via Adamello 16, 20139 Milan, Italy
    Mol Cell Proteomics 6:2200-11. 2007
    ..Our approach is especially useful to address complexes that are difficult in addressing by standard structural methods...
  44. ncbi The genetics and biology of DISC1--an emerging role in psychosis and cognition
    David J Porteous
    Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Crewe Road South, Edinburgh
    Biol Psychiatry 60:123-31. 2006
    ..DISC1 has also been shown to interact with a number of proteins with neurobiological pedigrees, including Ndel1 (NUDEL), a key regulator of neuronal migration with endo-oligopeptidase activity, and PDE4B, a phosphodiesterase that is ..
  45. pmc Functional genomics in postmortem human brain: abnormalities in a DISC1 molecular pathway in schizophrenia
    Barbara K Lipska
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Dialogues Clin Neurosci 8:353-7. 2006
    ..We hypothesized that altered expression of DISC1 and/or its molecular partners (nuclear distribution element-like [NUDEL], fasciculation and elongation protein zeta-i [FEZ1], and lissencephaly 1 [LIS1]) may underlie its pathogenic role ..
  46. ncbi Expression profiles of ndel1a and ndel1b, two orthologs of the NudE-Like gene, in the zebrafish
    Catherine M Drerup
    Children s Memorial Research Center, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA
    Gene Expr Patterns 7:672-9. 2007
    NudE-Like (NDEL1/NUDEL), through its interaction with LIS1 and DISC1, has been implicated in the etiology of neurological disorders such as lissencephaly and schizophrenia, respectively...
  47. pmc Biochemical defects of mutant nudel alleles causing early developmental arrest or dorsalization of the Drosophila embryo
    E K LeMosy
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genetics 154:247-57. 2000
    The nudel gene of Drosophila is maternally required both for structural integrity of the egg and for dorsoventral patterning of the embryo. It encodes a structurally modular protein that is secreted by ovarian follicle cells...
  48. ncbi Evidence for a glycosaminoglycan on the nudel protein important for dorsoventral patterning of the drosophila embryo
    Cynthia L Turcotte
    Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Dev Dyn 224:51-7. 2002
    Dorsoventral patterning of the Drosophila embryo requires Nudel, a large mosaic protein with a protease domain...
  49. doi Ndel1 controls the dynein-mediated transport of vimentin during neurite outgrowth
    Su Yeon Shim
    Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary T2N 4N1, Canada
    J Biol Chem 283:12232-40. 2008
    ..Our findings reveal a novel regulatory mechanism of vimentin transport during neurite extension that may have implications in diseases featuring transport/trafficking defects and impaired regeneration...
  50. doi An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics
    Daisuke Mori
    Department of Genetic Disease Research, Osaka City University, Japan
    Nat Cell Biol 11:1057-68. 2009
    ..These findings demonstrate a surprising role of aPKC-Aurora A-NDEL1 pathway in microtubule remodelling during neurite extension...
  51. pmc Genetic mosaic dissection of Lis1 and Ndel1 in neuronal migration
    Simon Hippenmeyer
    Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, CA 94305, USA
    Neuron 68:695-709. 2010
    ..Comparisons with previous genetic perturbations of Lis1 and Ndel1 also suggest a surprising degree of cell-nonautonomous function for these proteins in regulating neuronal migration...
  52. ncbi An unusual mosaic protein with a protease domain, encoded by the nudel gene, is involved in defining embryonic dorsoventral polarity in Drosophila
    C C Hong
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cell 82:785-94. 1995
    ..Here we present evidence that the nudel gene encodes an essential component of this cue...
  53. ncbi Three-dimensional models of proteases involved in patterning of the Drosophila Embryo. Crucial role of predicted cation binding sites
    Thierry Rose
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:11320-30. 2003
    Three-dimensional models of the catalytic domains of Nudel (Ndl), Gastrulation Defective (Gd), Snake (Snk), and Easter (Ea), and their complexes with substrate suggest a possible organization of the enzyme cascade controlling the ..
  54. ncbi [Current perspective on the pathogenesis of schizophrenia from the viewpoint of risk factors such as DISC1 (corrected)]
    Kozo Kaibuchi
    Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa Ku, Nagoya, 466 8550 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 30:149-52. 2010
    ..We here review the recent advance in understanding of pathophysiological functions of DISC1. [corrected]..
  55. ncbi What can we learn from the disrupted in schizophrenia 1 interactome: lessons for target identification and disease biology?
    Luiz M Camargo
    Schizophrenia and Bipolar Research, Wyeth Discovery Neuroscience, CN8000, Princeton, NJ 08543, USA
    Novartis Found Symp 289:208-16; discussion 216-21, 238-40. 2008
    ..interactions with the phosphodiesterase PDE4B in collaboration with the Porteous and Houslay labs, and with Ndel1-EOPA with Hayashi and colleagues...
  56. pmc LIS1 and NudE induce a persistent dynein force-producing state
    Richard J McKenney
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Cell 141:304-14. 2010
    Cytoplasmic dynein is responsible for many aspects of cellular and subcellular movement. LIS1, NudE, and NudEL are dynein interactors initially implicated in brain developmental disease but now known to be required in cell migration, ..
  57. pmc Dixdc1 is a critical regulator of DISC1 and embryonic cortical development
    Karun K Singh
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 67:33-48. 2010
    ..Together, these data reveal that Dixdc1 integrates DISC1 into Wnt-GSK3beta/beta-catenin-dependent and -independent signaling pathways during cortical development and further delineate how DISC1 contributes to neuropsychiatric disorders...
  58. pmc Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos
    Pamela W Steen
    Department of Cellular Biology and Anatomy, Medical College of Georgia, 1120 15th St, CB1101, Augusta, GA 30912, USA
    FEBS Lett 584:3557-60. 2010
    ..ventral and lateral cell fates requires spatial regulation of an extracellular serine protease cascade composed of Nudel, Gastrulation Defective (GD), Snake, and Easter...
  59. ncbi The polarity of the dorsoventral axis in the Drosophila embryo is defined by an extracellular signal
    D Stein
    Max Planck Institute für Entwicklungsbiologie, Tubingen, Federal Republic of Germany
    Cell 65:725-35. 1991
    ..Analysis of mosaic females indicates that the expression of the genes nudel, pipe, and windbeutel is required in the somatic tissue, presumably in the follicle cells that surround the oocyte...
  60. doi Depression, Cytokine, and Cytokine by Treatment Interactions Modulate Gene Expression in Antipsychotic Naïve First Episode Psychosis
    Cristiano Noto
    Department of Psychiatry, Universidade Federal de Sao Paulo UNIFESP, Rua Pedro de Toledo, 669, 3 andar, CEP 04039 032, Sao Paulo, SP, Brazil
    Mol Neurobiol 53:5701-9. 2016
    ..FEP patients with depression show a different gene expression profile reinforcing the theory that depression in FEP is a different phenotype. ..
  61. pmc Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages
    David J Doobin
    Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
    Nat Commun 7:12551. 2016
    ..These results reveal that the severity of NDE1-associated microcephaly results not from defects in mitosis, but rather the inability of neural progenitors to ever reach this stage. ..
  62. ncbi Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas
    Akira Watahiki
    Genome Science Laboratory, RIKEN, Wako Main Campus, 2 1 Hirosawa, Wako, Saitama, 351 0198 Japan
    Nat Methods 1:233-9. 2004
    ..Thus, the ASL approach proved effective in identifying splicing events, which suggest that alternative splicing is important in melanoma development...
  63. pmc Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly
    N Sawamura
    Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Mol Psychiatry 13:1138-48, 1069. 2008
    ..domains, such as the centrosome and the nucleus, and interacts with various proteins, including NudE-like (NUDEL/NDEL1) and activating transcription factor 4 (ATF4)/CREB2...
  64. pmc Bioinformatic and experimental survey of 14-3-3-binding sites
    Catherine Johnson
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD15EH, Scotland, U K
    Biochem J 427:69-78. 2010
    ..We speculate that 14-3-3 dimers may have contributed to the evolution of such families, tailoring regulatory inputs to different physiological demands...
  65. pmc Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population
    Lotte N Moens
    Applied Molecular Genomics Group, Department of Molecular Genetics, Flanders Institute for Biotechnology VIB, Flanders, Belgium
    PLoS ONE 6:e23450. 2011
    ..Further research into this unexplored domain will be required to elucidate the role of the identified variants in schizophrenia etiology...
  66. pmc Interactions of human truncated DISC1 proteins: implications for schizophrenia
    E N Newburn
    Clinical Brain Disorders Branch, National Institutes of Mental Health, National Institute of Health, Bethesda, MD 20892 1385, USA
    Transl Psychiatry 1:e30. 2011
    ..Our results suggest that complexes of full-length DISC1 with truncated DISC1 variants may result in cellular disturbances critical to DISC1 function...
  67. pmc The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution
    Dinesh C Soares
    Medical Genetics Section, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom
    J Biol Chem 287:32381-93. 2012
    ..It sheds light on recently identified mutations in the NDE1 gene that cause truncation of the encoded protein. Additionally, analysis of mixed NDE1-NDEL1 complexes demonstrates that NDE1 and NDEL1 can interact directly...
  68. pmc The phosphatase PP4c controls spindle orientation to maintain proliferative symmetric divisions in the developing neocortex
    Yunli Xie
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Neuron 79:254-65. 2013
    ..Our results identify a key regulator of cortical development and demonstrate that changes in the orientation of progenitor division are responsible for the transition between symmetric and asymmetric cell division. ..
  69. pmc NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'
    Nicholas J Bradshaw
    Department of Neuropathology, Heinrich Heine University Dusseldorf, University Medical School, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Biomol Concepts 4:447-64. 2013
    Nuclear distribution element 1 (NDE1, also known as NudE) and NDE-like 1 (NDEL1, also known as Nudel) are paralogous proteins essential for mitosis and neurodevelopment that have been implicated in psychiatric and neurodevelopmental ..
  70. pmc Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein
    Eva Klinman
    Neuroscience Graduate Group and Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
    Cell Rep 12:462-73. 2015
    ..Together, these studies identify CDK5 as a Lis1/Ndel1-dependent regulator of transport in stressed neurons, and suggest that dysregulated CDK5 activity contributes to the transport deficits observed during neurodegeneration. ..
  71. doi Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment
    Marijn Kuijpers
    Cell Biology, Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands
    Neuron 89:461-71. 2016
    ..We propose a model in which LIS1 is a critical mediator of local NDEL1-based dynein activation at the AIS. By localizing to the AIS, NDEL1 facilitates the reversal of somatodendritic cargos in the proximal axon...
  72. doi Genome-wide investigation of schizophrenia associated plasma Ndel1 enzyme activity
    Ary Gadelha
    Department of Psychiatry, Universidade Federal de Sao Paulo UNIFESP EPM, Sao Paulo, Brazil Electronic address
    Schizophr Res 172:60-7. 2016
    ..ZFPM2 and MAD1L1 were the only two genes with more than one hit at 10(-6) order of p value. Therefore, Ndel1 enzyme activity is a complex trait influenced by many different genetic variants that may contribute to SCZ physiopathology. ..
  73. doi Interaction between DISC1 and CHL1 in regulation of neurite outgrowth
    Jun Ren
    Department of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Beijing Institute for Brain Disorders, Center of Schizophrenia, Capital Medical University, Beijing 100069, China
    Brain Res 1648:290-7. 2016
    ....
  74. pmc Load-induced enhancement of Dynein force production by LIS1-NudE in vivo and in vitro
    Babu J N Reddy
    Department of Developmental and Cell Biology, University of California Irvine, Irvine, California 92697, USA
    Nat Commun 7:12259. 2016
    ..These results identify a novel, intrinsic, cargo-associated mechanism for dynein-mediated force adaptation, which should markedly improve the ability of motor-driven cargoes to overcome subcellular obstacles. ..
  75. doi NDEL1 was decreased in the CA3 region but increased in the hippocampal blood vessel network during the spontaneous seizure period after pilocarpine-induced status epilepticus
    Q Wu
    Department of Neurology, Xiangya Hospital, Central South University, 87 Xiang Ya Road, Changsha, Hunan 410008, China
    Neuroscience 268:276-83. 2014
    ..Based on these results, we hypothesize that NDEL1 might interact with DISC1 to activate ERK signaling and function as a potential protective factor during the spontaneous seizure period after pilocarpine-induced SE. ..
  76. pmc 14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain
    Kazuhito Toyo-oka
    Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco School of Medicine, San Francisco, California 94143, Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129
    J Neurosci 34:12168-81. 2014
    ..Our findings provide new evidence that 14-3-3 proteins play important roles in neurogenesis and neuronal migration via the regulation of distinct signaling cascades. ..
  77. ncbi Localized requirements for windbeutel and pipe reveal a dorsoventral prepattern within the follicular epithelium of the Drosophila ovary
    L A Nilson
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Cell 93:253-62. 1998
    ..The genes windbeutel, pipe, and nudel are required within the somatic follicle cells of the ovary for production of this spatial cue...
  78. pmc NudEL targets dynein to microtubule ends through LIS1
    Jun Li
    Department of Cell Biology and Physiology, Washington University in St Louis, School of Medicine, St Louis, MO 63110, USA
    Nat Cell Biol 7:686-90. 2005
    ..Several proteins regulate dynein activity, including dynactin, LIS1 (refs 2, 3) and NudEL (NudE-like). Here, we identify a NUDEL homologue in budding yeast and name it Ndl1...
  79. ncbi [Unique role of LIS1 and NDEL1 as a regulator of cytoplasmic dynein]
    Shinji Hirotsune
    Tanpakushitsu Kakusan Koso 51:586-90. 2006
  80. doi Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia
    Anjali Rastogi
    Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada
    Schizophr Res 114:39-49. 2009
    ..N=117 families; N=210 case-control pairs), testing polymorphisms across DISC1 and DISC1 interacting genes: LIS1, NUDEL, FEZ1 and PDE4B...
  81. pmc A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons
    Jai P Pandey
    Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA
    J Neurosci 31:17207-19. 2011
    ..Our data raise the possibility that defects in a Lis1/Ndel1 regulatory switch could contribute to neurodegenerative diseases linked to axonal pathology in adults...
  82. pmc MoMuLV-ts-1: A Unique Mouse Model of Retrovirus-Induced Lymphoma Transmitted by Breast Milk
    J Chakraborty
    Department of Physiology and Pharmacology, Block Health Science Building, College of Medicine, University of Toledo, Health Science Campus, Toledo, OH 43614, USA
    Adv Virol 2011:813651. 2011
    ..Since there is no report to date on this retroviral model leading to centrosomal abnormality, and causing lymphoma development, this is a valuable and unique model to study the centrosomal involvement in lymphomagenesis...
  83. doi Multiple modes of cytoplasmic dynein regulation
    Richard B Vallee
    Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
    Nat Cell Biol 14:224-30. 2012
    ..Recent work has distinguished high- and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions...
  84. pmc Misfolded Gβ is recruited to cytoplasmic dynein by Nudel for efficient clearance
    Yihan Wan
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Cell Res 22:1140-54. 2012
    ..Sustained activation of Gβγ signaling further elevated cellular levels of the ubiquitinated Gβ. Moreover, Nudel, a regulator of cytoplasmic dynein, the microtubule minus end-directed motor, directly interacted with both the ..
  85. pmc Ndel1-derived peptides modulate bidirectional transport of injected beads in the squid giant axon
    Michal Segal
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Biol Open 1:220-31. 2012
    ..We propose that they may function primarily by inhibition of dynein-dependent resistance, which suggests that both dynein and kinesin motors may remain engaged with microtubules during bidirectional transport...
  86. ncbi Role of DISC1 in neural development and schizophrenia
    Shaun Mackie
    Medical Genetics Section, University of Edinburgh Centre for Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    Curr Opin Neurobiol 17:95-102. 2007
    ..Genetic variants of DISC1 also predispose to related affective (mood) disorders. As a consequence, we can speculate on the mechanisms of DISC1 action and possible routes to treatment for these common, debilitating brain disorders...
  87. ncbi Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder
    Chihiro Kakiuchi
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Neurosci Lett 417:316-21. 2007
    ..As interacting-proteins with DISC1, Nudel, ATF4, ATF5, LIS1, alpha-tubulin, PDE4B, eIF3, FEZ1, Kendrin, MAP1A and MIPT3 were identified...
  88. pmc Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses
    Liisa Tomppo
    Institute for Molecular Medicine Finland FIMM and National Public Health Institute, Helsinki, Finland
    Biol Psychiatry 65:1055-62. 2009
    ..Because both DISC1 and NDE1 display association in our study sample, we hypothesized that other genes interacting with DISC1 might also have a role in the etiology of schizophrenia...
  89. doi Opposing effects of Ndel1 and alpha1 or alpha2 on cytoplasmic dynein through competitive binding to Lis1
    Chong Ding
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Cell Sci 122:2820-7. 2009
    ..They also help to explain why brain development is particularly sensitive to a decrease in Lis1 levels...
  90. doi A unique role of dynein and nud family proteins in corticogenesis
    Shiori Toba
    Department of Genetic Disease Research, Osaka City University Graduate School of Medicine, Osaka, Japan
    Neuropathology 32:432-9. 2012
    ..Endeavoring to address the regulation of the microtubule network and motor proteins will help in understanding not only corticogenesis but neurodegenerative disorders...
  91. pmc The maternal nudel protein of Drosophila has two distinct roles important for embryogenesis
    C C Hong
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genetics 143:1653-61. 1996
    The nudel gene is maternally required to define dorsoventral polarity of the Drosophila embryo. It encodes an unusual mosaic protein with a protease domain that may trigger the protease cascade required for ventral development...
  92. ncbi Role of Nudel protease activation in triggering dorsoventral polarization of the Drosophila embryo
    E K LeMosy
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520 8002, USA
    Development 125:4045-53. 1998
    ..This mechanism requires the activity of the nudel gene in ovarian follicle cells, which provide dorsoventral positional information for the embryo...
  93. ncbi The nudel protease of Drosophila is required for eggshell biogenesis in addition to embryonic patterning
    E K LeMosy
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Dev Biol 217:352-61. 2000
    ..members of the serine protease family, including a large modular protein with a protease domain encoded by the nudel gene. Here we provide evidence that the Nudel protease has an integral role in eggshell biogenesis...
  94. ncbi Molecular and immunochemical evidences demonstrate that endooligopeptidase A is the predominant cytosolic oligopeptidase of rabbit brain
    M A Hayashi
    Department of Biophysics and Biochemistry, Butantan Institute, Sao Paulo, Brazil
    Biochem Biophys Res Commun 269:7-13. 2000
    ..The rabbit brain endooligopeptidase A and the rat testes soluble metallopeptidase (EC 3.4.24...
  95. pmc Gastrulation defective is a serine protease involved in activating the receptor toll to polarize the Drosophila embryo
    J H Han
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 97:9093-7. 2000
    ..reaction, which occurs at the end of a proteolytic cascade and requires the gastrulation defective (gd), nudel, pipe, and windbeutel genes...
  96. ncbi NudE-L, a novel Lis1-interacting protein, belongs to a family of vertebrate coiled-coil proteins
    K J Sweeney
    Max Planck Institute for Experimental Endocrinology, Feodor Lynen Strasse 7, 30625, Hannover, Germany
    Mech Dev 101:21-33. 2001
    ....
  97. ncbi Expression of endo-oligopeptidase A in the rat central nervous system: a non-radioactive in situ hybridization study
    M A Hayashi
    Department of Biophysics and Biochemistry, Butantan Institute, Sao Paulo, Brazil
    Brain Res Mol Brain Res 89:86-93. 2001
    Endo-oligopeptidase A (EOPA, formerly EC 3.4.22.19), a thiol-activated oligopeptidase, is able to degrade both bradykinin and neurotensin, and also to convert enkephalin-containing peptides into enkephalins...
  98. ncbi Expression of NUDEL in manchette and its implication in spermatogenesis
    Noritaka Yamaguchi
    Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    FEBS Lett 566:71-6. 2004
    Nuclear distribution gene E-like product (NUDEL) is a mammal homologue of fungal NUDE and is involved in neuronal migration during brain development. High levels of NUDEL were expressed in murine testis as well as brain...
  99. ncbi A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons
    Minh Dang Nguyen
    Department of Pathology, Harvard Medical School and Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, New Research Building, Room 856 8, MA 02115, USA
    Nat Cell Biol 6:595-608. 2004
    ..Here we report that NUDEL, a mammalian homologue of the Aspergillus nidulans nuclear distribution molecule NudE, is important for NF ..
  100. ncbi Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment
    I L Schurov
    Merck Sharp and Dohme, The Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK
    Mol Psychiatry 9:1100-10. 2004
    ..We have recently presented evidence that DISC1 exists in a neurodevelopmentally regulated protein complex with Nudel. In this study, we report the protein expression profile of DISC1 in the adult and developing mouse brain ..
  101. ncbi Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning
    Tianzhi Shu
    Department of Pathology, Harvard Medical School and Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Neuron 44:263-77. 2004
    ..RNA interference (RNAi), we found that the binding partner of LIS1, NudE-like protein (Ndel1, formerly known as NUDEL), positively regulates dynein activity by facilitating the interaction between LIS1 and dynein...

Research Grants14

  1. Role of neuronal migration genes in synaptogenesis and plasticity
    Anamaria Sudarov; Fiscal Year: 2013
    ..We will investigate the role of Lis1 in the regulation of proper formation and elimination of connections between neurons that must be carefully orchestrated throughout development. ..
  2. Atsushi Kamiya; Fiscal Year: 2014
    ..This study will be able to contribute to the identification of genetic risk-mediated molecular pathway in the specific developmental periods which leads to disease susceptibility. ..
  3. Terry H Lechler; Fiscal Year: 2016
    ..We will characterize novel mechanisms that desmosomes use to reorganize the cytoskeleton. This will allow an understanding of how desmosome disruption results in such a diversity of pathological phenotypes. ..
  4. Deanna S Smith; Fiscal Year: 2016
    ..Lis1 and a binding partner, Nudel, bind directly to dynein and regulate its activity...
  5. Spatial Control of Proteolysis in Dorsoventral Polarity
    ELLEN LEMOSY; Fiscal Year: 2009
    ..receptor Toll is generated by a proteolytic processing reaction involving 4 members of a serine protease cascade, Nudel, Gastrulation Defective (GD), Snake and Easter...
  6. Akira Sawa; Fiscal Year: 2016
    ..In this center, 6 projects and 2 cores will collaborate to achieve these scientific goals. ..
  7. Steven P Gross; Fiscal Year: 2014
    ..wide range of dynein roles is made possible by tuning its function with accessory proteins such as Lis1, NudE, and NudEL. However, while genetic studies, both via mutagenesis in model organisms, and via identification of causative/risk ..
  8. Yixian Zheng; Fiscal Year: 2014
    ..Since lamin-B interacts with the dynein regulator NudEL and the microtubule depolymerase MCAK, we hypothesize that the lamin-B spindle sheath that surrounds the body of ..
  9. SIGNAL TRANSDUCTION PATHWAY MEDIATING CDK5 FUNCTION
    Li Huei Tsai; Fiscal Year: 2006
    ..We and others showed that mammalian Lis 1 interacts with cytoplasmic dynein and modulates dynein activity. Nudel is a novel protein that interacts with both Lis 1 and dynein...
  10. Genetic Analysis of LIS1 Function in the Mouse
    Anthony Wynshaw Boris; Fiscal Year: 2009
    ..to LIS1 and CDHC regulates the function of dynein, and this binding is responsible for the in vivo phenotypes of mice with mutations in the LIS1/NUDEL/CDHC complex by producing Ndell alleles defective in binding for LIS1 and CDHC.
  11. Fine-tuning of LIS1-Nudel Interactions
    Li Huei Tsai; Fiscal Year: 2006
    ..Among several substrates, cdk5 phosphorylates Nudel, a LIS1/dynein interacting protein...
  12. Genetic Regulation of Neuronal Migration
    Anthony Wynshaw Boris; Fiscal Year: 2009
    ..Aim 2 Test the hypothesis that the phosphorylation of NUDEL by Cdk5/p35 and binding to 14-3-3epsilon are critical for neuronal development and migration in vivo by producing ..
  13. Molecular Genetics of Cytoplasmic Dyein
    RICHARD BERT VALLEE; Fiscal Year: 2010
    ..The final aim has particular significance for the control of acute viral infection and the design of gene delivery vectors and strategies. ..
  14. Biology of Serine Proteases and Serpins
    Carl Hashimoto; Fiscal Year: 2010
    ..abstract_text> ..