Genomes and Genes
Gene Symbol: NUCKS
Description: nuclear casein kinase and cyclin dependent kinase substrate 1
Alias: JC7, NUCKS, nuclear ubiquitous casein and cyclin-dependent kinase substrate 1, nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate, potential LAG1 interactor
- Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivoA C Ostvold
Department of Medical Biochemistry, University of Oslo, Norway
Eur J Biochem 268:2430-40. 2001We have isolated and characterized a cDNA encoding a mammalian nuclear phosphoprotein NUCKS, previously designated P1...
- Identification and confirmation of a module of coexpressed genesH Garrett R Thompson
Department of Biomedical Engineering, University of California Irvine, Irvine, California 92697, USA
Genome Res 12:1517-22. 2002..contains at least six members that are believed to be involved in either transcritional regulation (PDEF, H2AFO, NUCKS) or the ubiquitin proteasome pathway (PSMD7, SQSTM1, FLJ10111)...
- A putative DNA-binding domain in the NUCKS proteinKirsten Grundt
Department of Medical Biochemistry, University of Oslo, Box 1115 Blindern, Oslo, Norway
Arch Biochem Biophys 407:168-75. 2002We have studied the DNA-binding properties of a NUCKS-derived, synthetic peptide containing an extended GRP motif. This peptide binds to random-sequence DNA, but did not bind preferentially to poly(dA-dT)...
- Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different speciesKirsten Grundt
Department of Medical Biochemistry, Institute Group of Basic Medical Sciences, University of Oslo, Norway
Biochem Biophys Res Commun 323:796-801. 2004The NUCKS gene is located on human chromosome 1q32.1 and consists of seven exons and six introns. The gene lacks a TATA box but contains two Inr elements, two GC boxes, and one consensus-binding site for E2F-1...
- Identification and characterization of two putative nuclear localization signals (NLS) in the DNA-binding protein NUCKSKirsten Grundt
Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, P O Box 1112, Blindern, 0317 Oslo, Norway
Biochim Biophys Acta 1773:1398-406. 2007Immunofluorescence analyses show that the vertebrate specific and DNA-binding protein NUCKS is distributed throughout the cytoplasm in mitotic cells and targeted to the reforming nuclei in late telophase of the cell cycle...
- Constitutive and dynamic phosphorylation and acetylation sites on NUCKS, a hypermodified nuclear protein, studied by quantitative proteomicsJacek R Wisniewski
Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried, Germany
Proteins 73:710-8. 2008Nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) is a 27 kDa chromosomal protein of unknown function...
- NUCKS1 overexpression is a novel biomarker for recurrence-free survival in cervical squamous cell carcinomaLina Gu
Department of Gynecology, The Third Affiliated Hospital, Harbin Medical University, Baojian Road 6, Nangang District, 150081, Harbin, China
Tumour Biol 35:7831-6. 2014..060 to 4.535; P = 0.034). In conclusion, NUCKS1 overexpression may be associated with tumour progression and recurrence in CSCCs and may thus serve as a new molecular marker for the prediction of RFS in these patients...
- Inhibition of NUCKS Facilitates Corneal Recovery Following Alkali BurnMing Wai Poon
Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
Sci Rep 7:41224. 2017..Nuclear Ubiquitous Casein and cyclin-dependent Kinase Substrate (NUCKS) is a key chromatin modifier and transcriptional regulator of metabolic signaling...
- Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypesVladimir Vacic
Department of Computer Science, Columbia University, New York, NY, USA
Hum Mol Genet 23:4693-702. 2014..Our results highlight the power of our haplotype association method, particularly useful in studies of founder populations, and reaffirm the benefits of studying complex diseases in Ashkenazi Jewish cohorts. ..
- NUCKS is a positive transcriptional regulator of insulin signalingBeiying Qiu
Institute of Molecular and Cell Biology, Agency for Science, Technology and Research A STAR, Singapore 138673, Singapore
Cell Rep 7:1876-86. 2014..We now find that NUCKS is a transcriptional regulator of the insulin signaling components, including the insulin receptor (IR)...
- The comparison of nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) with Ki67 proliferation marker expression in common skin tumorsKrzysztof Zduniak
Prof dr Piotr Ziółkowski Department of Pathology Wroclaw Medical University 1 Marcinkowskiego 50 368 Wrocław, Poland tel 48 71 784 12 12 fax 48 71 784 00 57 e mail
Pol J Pathol 65:48-54. 2014Nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) is a chromosomal protein of unknown function...
- Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studiesSoriul Kim
Department of Public Health, Graduate School, Yonsei University, Seoul, Republic of Korea Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea
Gene 556:199-205. 2015..We suggest that our results for some but not all PCa risk SNPs to be associated with PSA levels could be used as an evidence for the advance of individual PCa screening strategies, such as applying a personalized cutoff value for PSA...
- NUCKS: a potential biomarker in cancer and metabolic diseaseBeiying Qiu
Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, 138673, Singapore
Clin Sci (Lond) 128:715-21. 2015Nuclear, casein kinase and cyclin-dependent kinase substrate (NUCKS), a protein similar to the HMG (high-mobility group) protein family, is one of the most modified proteins in the mammalian proteome...
- Fine mapping and resequencing of the PARK16 locus in Parkinson's diseaseLasse Pihlstrøm
1 Department of Neurology, Oslo University Hospital, Oslo, Norway 2 University of Oslo, Institute of Clinical Medicine, Oslo, Norway
J Hum Genet 60:357-62. 2015..Comparing our results with previous work, allelic heterogeneity at PARK16 appears likely, and further studies are warranted to disentangle the complex patterns of association and pinpoint the functionally relevant variants. ..
- Hypothalamic NUCKS regulates peripheral glucose homoeostasisBeiying Qiu
Institute of Molecular and Cell Biology, Agency for Science, Technology and Research A STAR, Singapore
Biochem J 469:391-8. 2015Nuclear ubiquitous casein and cyclin-dependent kinase substrate (NUCKS) is highly expressed in the brain and peripheral metabolic organs, and regulates transcription of a number of genes involved in insulin signalling...
- NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stabilityAnn C Parplys
Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Nucleic Acids Res 43:9817-34. 2015..Our results show that NUCKS1 is a chromatin-associated protein with a role in the DNA damage response and in HR, a DNA repair pathway critical for tumor suppression. ..
- Association of Parkinson's Disease GWAS-Linked Loci with Alzheimer's Disease in Han ChineseXi Chen Zhu
Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Qingdao, China
Mol Neurobiol 54:308-318. 2017..Our results first time indicated rs76904798 of LRRK2 is also a common risk genetic variant for LOAD susceptibility in a northern Han Chinese people...
- Association of three candidate genetic variants in RAB7L1/NUCKS1, MCCC1 and STK39 with sporadic Parkinson's disease in Han ChineseLing Wang
Department of Neurology, West China Hospital, Sichuan University, Sichuan, 610041, Sichuan Province, People s Republic of China
J Neural Transm (Vienna) 123:425-30. 2016..Our study provides strong support for the susceptibility role of rs823118 and rs12637471 in sporadic PD in a Han Chinese population...
- Identification of NUCKS1 as a putative oncogene and immunodiagnostic marker of hepatocellular carcinomaJae Youn Cheong
Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea Genome Research Center for Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea Electronic address
Gene 584:47-53. 2016..NUCKS1 was identified as a potential oncogene at chromosomal 1q32.1 in patients with HCC, and it might be a valuable immunodiagnostic marker for HCC. ..
- MicroRNA-137 inhibits tumor growth and sensitizes chemosensitivity to paclitaxel and cisplatin in lung cancerHua Shen
Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China
Oncotarget 7:20728-42. 2016..Identification of a novel miRNA-mediated pathway that regulates chemosensitivity in lung cancer will facilitate the development of novel therapeutic strategies in the future. ..
- Nucks1 synergizes with Trp53 to promote radiation lymphomagenesis in miceYangBo Yue
Department of Organismal Systems and Bioresilience, Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Oncotarget . 2016..We propose that, in the context of Trp53 deficiency, wild type levels of Nucks1 are required to suppress radiation-induced TL, likely through the role of the NUCKS1 protein in the DNA damage response...
- Identification of kinases phosphorylating 13 sites in the nuclear, DNA-binding protein NUCKSKirsten Grundt
University of Oslo, Institute of Basic Medical Sciences, Department of Biochemistry, P O Box 1112, Blindern N 0317, Oslo, Norway
Biochim Biophys Acta . 2016b>NUCKS is a vertebrate specific, nuclear and DNA-binding phospho protein. The protein is highly expressed in rapidly dividing cells, and is overexpressed in a number of cancer tissues...
- Effect of NUCKS-1 overexpression on cytokine profiling in obese women with breast cancerNema Ali Soliman
Departments of Medical Biochemistry, 2Departments of General Surgery, Faculty of Medicine, Tanta University, Tanta, Egypt E mail mail com
Asian Pac J Cancer Prev 15:837-45. 2014..The nuclear, casein kinase and cyclin-dependent kinase substrate-1 (NUCKS-1), is a nuclear DNA-binding protein that has been implicated in several human cancers, including breast cancer.
- Dynamic expression of the vertebrate-specific protein Nucks during rodent embryonic developmentYiannis Drosos
Department of Genetics and Biotechnology, Faculty of Biology, University of Athens, Panepistimioupoli, 15701 Ilissia, Greece Electronic address
Gene Expr Patterns 14:19-29. 2014The nuclear casein kinase and cyclin-dependent kinase substrate 1 (NUCKS) is a highly phosphorylated nuclear protein that is overexpressed in many types of cancer...
- Screening E3 substrates using a live phage display libraryZhengguang Guo
Department of Physiology and Pathophysiology, National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences School of Basic Medicine, Peking Union Medical College, Beijing, China Department of Core Instrument Facility, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences School of Basic Medicine, Peking Union Medical College, Beijing, China
PLoS ONE 8:e76622. 2013..The whole strategy is rather simple and efficient. Non-degradation substrates can be discovered. This strategy can be extended to any E3s as long as the E3 does not ubiquitinate the empty phage. ..
- Combined evaluation of the expression of NUCKS and Ki-67 proteins as independent prognostic factors for patients with gastric adenocarcinomaMing Yang
Department of Gastrointestinal Medical Oncology, The Affiliated Tumour Hospital of Harbin Medical University, Harbin, Heilongjiang, China
Tumour Biol 35:7505-12. 2014Nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) has been recently documented in various malignancies. However, data regarding the expression and prognostic value of NUCKS in gastric adenocarcinoma are limited...
- Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalitiesJonathan Savitz
Laureate Institute for Brain Research, Tulsa, OK 74136, USA
Brain Behav Immun 31:161-71. 2013..Our results raise the possibility that molecular-level immune dysfunction can be mapped onto macro-level neuroimaging abnormalities, potentially elucidating a mechanism by which inflammation leads to depression...
- NUCKS overexpression in breast cancerYiannis Drosos
Department of Genetics and Biotechnology, Faculty of Biology, University of Athens, Panepistimioupoli, 15701 Ilissia, Greece
Cancer Cell Int 9:19. 2009b>NUCKS (Nuclear, Casein Kinase and Cyclin-dependent Kinase Substrate) is a nuclear, DNA-binding and highly phosphorylated protein...
- Identification of NUCKS1 as a colorectal cancer prognostic marker through integrated expression and copy number analysisAkifumi Kikuchi
Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
Int J Cancer 132:2295-302. 2013..The overexpression of NUCKS1 in cancer cells could be used as a CRC prognostic marker and might also be a target for treatment of this disease...
- Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese populationJielin Sun
Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
Hum Genet 132:423-9. 2013..Identification of these genetic markers provides new insight into the molecular mechanisms of PSA. Taking individual variation into account, these genetic variants may improve the performance of PSA to predict prostate cancer...
- [Cyst of Nucks canal associated with recurrent inguinal hernia]Denzil Garteiz Martínez
Hospital Angeles Lomas, Huixquilucan, Estado de Mexico
Ginecol Obstet Mex 81:52-6. 2013..We report the case of a woman with a cyst of Nuck that presented as a recurrent inguinal hernia. Discussion is centered on the embryologic, anatomic, clinical and therapeutic aspects of this condition...
- MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemiaF Akbari Moqadam
Department of Pediatric Oncology and Hematology, Erasmus MC Sophia Children s Hospital, University Medical Centre Rotterdam, Rotterdam, The Netherlands
Leuk Res 37:1315-21. 2013..05). The concerted function of miR-125b in combination with miR-99a and/or miR-100 illustrates the complexity of vincristine-resistant pediatric ALL...
- Immunocytochemical studies on the nuclear ubiquitous casein and cyclin-dependent kinases substrate following 5-aminolevulinicacid-mediated photodynamic therapy on MCF-7 cellsKatarzyna Hotowy
Department of Clinical Biochemistry, Wroclaw Medical University, 50 367 Wrocław, Poland
Photodiagnosis Photodyn Ther 10:518-25. 2013Recent data indicates that nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) may play role in tumor growth...
- Identification of nine novel loci associated with white blood cell subtypes in a Japanese populationYukinori Okada
Laboratory for Statistical Analysis, Center for Genomic Medicine, Institute of Physical and Chemical Research, Yokohama, Japan
PLoS Genet 7:e1002067. 2011..This study should contribute to the understanding of the genetic backgrounds of the WBC subtypes and hematological traits...
- Genetic variability at the PARK16 locusArianna Tucci
Department of Molecular Neuroscience and Reta Lila Weston Institute, UCL Institute of Neurology, London, UK
Eur J Hum Genet 18:1356-9. 2010....
- Immunohistochemical and proteomic evaluation of nuclear ubiquitous casein and cyclin-dependent kinases substrate in invasive ductal carcinoma of the breastPiotr Ziółkowski
Department of Pathology, Wrocław Medical University, 1 Marcinkowskiego Street, 50 368 Wroclaw, Poland
J Biomed Biotechnol 2009:919645. 2009Nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) is 27 kDa chromosomal protein of unknown function...
- Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's diseaseWataru Satake
Division of Neurology Molecular Brain Science, Kobe University Graduate School of Medicine, Kobe, Japan
Nat Genet 41:1303-7. 2009..Our results identify two new PD susceptibility loci, show involvement of autosomal dominant parkinsonism loci in typical PD and suggest that population differences contribute to genetic heterogeneity in PD...
- Genome-wide association study reveals genetic risk underlying Parkinson's diseaseJavier Simon-Sanchez
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
Nat Genet 41:1308-12. 2009..14, P = 1.55 x 10(-5)). These data demonstrate an unequivocal role for common genetic variants in the etiology of typical PD and suggest population-specific genetic heterogeneity in this disease...
- Chromosomal changes in high- and low-invasive mouse lung adenocarcinoma cell strains derived from early passage mouse lung adenocarcinoma cell strainsLinda M Sargent
National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Toxicol Appl Pharmacol 233:81-91. 2008..analysis and confirmation by real time PCR demonstrated increased expression of COX-2, Translin (TB-RBP), DYRK3, NUCKS and Tubulin-alpha4 genes in the high-invasive cell strains...
- Cell adhesion molecule SC1/DMGRASP is expressed on growing axons of retina ganglion cells and is involved in mediating their extension on axonsG E Pollerberg
Max Planck Institute for Developmental Biology, Department of Biochemistry, Tubingen, Germany
Dev Biol 165:670-87. 1994..including the N-terminal amino acid sequence, with a cell adhesion molecule termed DM-GRASP, SC1, BEN, and JC7. It can therefore be considered identical with this molecule and is referred to as SC1/DMGRASP...
- Claudia Wiese; Fiscal Year: 2016..Nuclear Ubiquitous Casein and Cyclin-dependent Kinases Substrate (NUCKS) is a 27 kD, DNA-binding and vertebrate-specific protein with unknown function...
- Role of H11 kinase in cardiac cell growthChristophe Depre; Fiscal Year: 2007..Putative interactions include the nuclear casein kinase II (NUCKS II), a stimulator of cell growth, the protein HSP27, a stimulator of cell survival, and the nucleosome assembly ..