NSF

Summary

Gene Symbol: NSF
Description: N-ethylmaleimide sensitive factor, vesicle fusing ATPase
Alias: SEC18, SKD2, vesicle-fusing ATPase, N-ethylmaleimide-sensitive factor-like protein, N-ethylmaleimide-sensitive fusion protein, NEM-sensitive fusion protein, vesicular-fusion protein NSF
Species: human

Top Publications

  1. pmc Genomics, molecular imaging, bioinformatics, and bio-nano-info integration are synergistic components of translational medicine and personalized healthcare research
    Jack Y Yang
    Harvard Medical School, Harvard University, Cambridge, Massachusetts 02115, USA
    BMC Genomics 9:I1. 2008
  2. ncbi The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin
    P I Hanson
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 270:16955-61. 1995
  3. pmc Genome-wide association study reveals genetic risk underlying Parkinson's disease
    Javier Simon-Sanchez
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 41:1308-12. 2009
  4. pmc Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease
    Taye H Hamza
    New York State Department of Health Wadsworth Center, Albany, New York, USA
    Nat Genet 42:781-5. 2010
  5. pmc Evidence of a role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) machinery in HIV-1 assembly and release
    Anjali Joshi
    Center of Excellence for Infectious Diseases, Department of Biomedical Sciences, Texas Tech University Health Sciences Center, El Paso, Texas 79905, USA
    J Biol Chem 286:29861-71. 2011
  6. pmc N-ethylmaleimide-sensitive fusion protein: a trimeric ATPase whose hydrolysis of ATP is required for membrane fusion
    S W Whiteheart
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York 10021
    J Cell Biol 126:945-54. 1994
  7. pmc Selective packaging of cargo molecules into endoplasmic reticulum-derived COPII vesicles
    J L Campbell
    Department of Molecular and Cell Biology, and Howard Hughes Medical Institute, University of California, Berkeley 94720 3202, USA
    Proc Natl Acad Sci U S A 94:837-42. 1997
  8. ncbi The karyogamy gene KAR2 and novel proteins are required for ER-membrane fusion
    M Latterich
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Cell 78:87-98. 1994
  9. pmc COPI-independent anterograde transport: cargo-selective ER to Golgi protein transport in yeast COPI mutants
    E C Gaynor
    Department of Biology, University of California, San Diego, La Jolla 92093 0668, USA
    J Cell Biol 136:789-802. 1997
  10. ncbi NBD-labeled phosphatidylcholine and phosphatidylethanolamine are internalized by transbilayer transport across the yeast plasma membrane
    A M Grant
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Traffic 2:37-50. 2001

Detail Information

Publications258 found, 100 shown here

  1. pmc Genomics, molecular imaging, bioinformatics, and bio-nano-info integration are synergistic components of translational medicine and personalized healthcare research
    Jack Y Yang
    Harvard Medical School, Harvard University, Cambridge, Massachusetts 02115, USA
    BMC Genomics 9:I1. 2008
    Supported by National Science Foundation (NSF), International Society of Intelligent Biological Medicine (ISIBM), International Journal of Computational Biology and Drug Design and International Journal of Functional Informatics and ..
  2. ncbi The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin
    P I Hanson
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 270:16955-61. 1995
    The N-ethylmaleimide-sensitive fusion protein (NSF) plays an essential role in intracellular membrane fusion events and has been implicated in the exocytosis of synaptic vesicles...
  3. pmc Genome-wide association study reveals genetic risk underlying Parkinson's disease
    Javier Simon-Sanchez
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 41:1308-12. 2009
    ..14, P = 1.55 x 10(-5)). These data demonstrate an unequivocal role for common genetic variants in the etiology of typical PD and suggest population-specific genetic heterogeneity in this disease...
  4. pmc Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease
    Taye H Hamza
    New York State Department of Health Wadsworth Center, Albany, New York, USA
    Nat Genet 42:781-5. 2010
    ..The genetic association with HLA supports the involvement of the immune system in Parkinson's disease and offers new targets for drug development...
  5. pmc Evidence of a role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) machinery in HIV-1 assembly and release
    Anjali Joshi
    Center of Excellence for Infectious Diseases, Department of Biomedical Sciences, Texas Tech University Health Sciences Center, El Paso, Texas 79905, USA
    J Biol Chem 286:29861-71. 2011
    ..Our findings demonstrate for the first time a role of SNARE proteins in HIV-1 assembly and release, likely by affecting cellular trafficking pathways required for Gag transport and association with the plasma membrane...
  6. pmc N-ethylmaleimide-sensitive fusion protein: a trimeric ATPase whose hydrolysis of ATP is required for membrane fusion
    S W Whiteheart
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York 10021
    J Cell Biol 126:945-54. 1994
    The NEM-sensitive fusion protein, NSF, together with SNAPs (soluble NSF attachment proteins) and the SNAREs (SNAP receptors), is thought to be generally used for the fusion of transport vesicles to their target membranes...
  7. pmc Selective packaging of cargo molecules into endoplasmic reticulum-derived COPII vesicles
    J L Campbell
    Department of Molecular and Cell Biology, and Howard Hughes Medical Institute, University of California, Berkeley 94720 3202, USA
    Proc Natl Acad Sci U S A 94:837-42. 1997
    ..We used this assay to investigate how targeting [v-SNARE, vesicle-soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor], putative adapter (e.g...
  8. ncbi The karyogamy gene KAR2 and novel proteins are required for ER-membrane fusion
    M Latterich
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Cell 78:87-98. 1994
    ..we find that fusion between ER compartments requires ATP, but not cytosol, Sec17p (alpha-SNAP), or Sec18p (NSF), the latter two being required at the fusion step in vesicular transport...
  9. pmc COPI-independent anterograde transport: cargo-selective ER to Golgi protein transport in yeast COPI mutants
    E C Gaynor
    Department of Biology, University of California, San Diego, La Jolla 92093 0668, USA
    J Cell Biol 136:789-802. 1997
    ..In contrast, all proteins tested required COPII (ER to Golgi coat complex), Sec18p (NSF), and Sec22p (v-SNARE) for ER to Golgi transport...
  10. ncbi NBD-labeled phosphatidylcholine and phosphatidylethanolamine are internalized by transbilayer transport across the yeast plasma membrane
    A M Grant
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Traffic 2:37-50. 2001
    ..The sec18/NSF mutation was unique among the sec mutations in further blocking M-C6-NBD-PC translocation to the vacuole ..
  11. pmc Crystal structure of the Sec18p N-terminal domain
    S M Babor
    Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 96:14759-64. 1999
    Yeast Sec18p and its mammalian orthologue N-ethylmaleimide-sensitive fusion protein (NSF) are hexameric ATPases with a central role in vesicle trafficking...
  12. ncbi Cloning and characterization of the SEC18 gene from Candida albicans
    A Nieto
    , , Burjassot, Valencia, Spain
    Yeast 9:875-87. 1993
    The SEC18 gene product is required for protein transport at different stages in the Saccharomyces cerevisiae secretory pathway. The homologous SEC18 gene from Candida albicans has been cloned by complementation of a sec18-1 S...
  13. ncbi Functional conservation of cytosolic proteins required for endosomal vesicle fusion
    P G Woodman
    School of Biological Sciences, University of Manchester, UK
    Yeast 12:1251-62. 1996
    ..The extent to which components of this process are functionally conserved is apparent from the finding that yeast Sec18 protein (Sec18p) can substitute or mammalian NSF in intra-Golgi transport reactions...
  14. ncbi Surface expression of AMPA receptors in hippocampal neurons is regulated by an NSF-dependent mechanism
    J Noel
    Medical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, United Kingdom
    Neuron 23:365-76. 1999
    Here, we show that disruption of N-ethylmaleimide-sensitive fusion protein- (NSF-) GluR2 interaction by infusion into cultured hippocampal neurons of a blocking peptide (pep2m) caused a rapid decrease in the frequency but no change in ..
  15. pmc Ergosterol is required for the Sec18/ATP-dependent priming step of homotypic vacuole fusion
    M Kato
    Department of Biochemistry, Dartmouth Medical School, Vail Building, Hanover, NH 03755 3844, USA
    EMBO J 20:4035-40. 2001
    In vitro homotypic fusion of yeast vacuoles occurs in three stages: priming, the Sec18 (NSF)-mediated changes that precede vacuole association; docking, the Ypt7 and SNARE-mediated pairing of vacuoles; and fusion, mediated by calmodulin/..
  16. pmc Morphological analysis of protein transport from the ER to Golgi membranes in digitonin-permeabilized cells: role of the P58 containing compartment
    H Plutner
    Department of Cell and Molecular Biology, Scripps Research Institute, La Jolla, California 92037
    J Cell Biol 119:1097-116. 1992
    ..with p58 in the absence of Ca2+ or the presence of an antibody which inhibits the transport component NSF (SEC18)...
  17. pmc Homotypic vacuole fusion requires Sec17p (yeast alpha-SNAP) and Sec18p (yeast NSF)
    A Haas
    Department of Biochemistry, Dartmouth Medical School, NH 03775 3844, USA
    EMBO J 15:3296-305. 1996
    ..antibodies and purified recombinant proteins, a requirement for Sec17p (yeast alpha-SNAP) and Sec18p (yeast NSF) in homotypic vacuole fusion in vitro...
  18. doi Immunohistochemical aspects of the fibrogenic pathway in nephrogenic systemic fibrosis
    Pascale Quatresooz
    Department of Dermatopathology, University Hospital of Liege, Liege, Belgium
    Appl Immunohistochem Mol Morphol 18:448-52. 2010
    Nephrogenic systemic fibrosis (NSF) is a rare gadolinium-dependent disorder of the skin and viscera...
  19. ncbi The docking of primed vacuoles can be reversibly arrested by excess Sec17p (alpha-SNAP)
    L Wang
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755 3844, USA
    J Biol Chem 275:22862-7. 2000
    ..prepares vacuoles for productive association, requires Sec17p (the yeast homolog of alpha-SNAP), Sec18p (the yeast NSF, an ATP-driven chaperone), and ATP...
  20. ncbi Novel function of DUSP14/MKP6 (dual specific phosphatase 14) as a nonspecific regulatory molecule for delayed-type hypersensitivity
    Y Nakano
    Division of Environmental Health, Osaka Prefectural Institute of Public Health, Higashinari, Osaka, Japan
    Br J Dermatol 156:848-60. 2007
    ..we found a unique regulatory mechanism of contact hypersensitivity (CHS) mediated by nonspecific suppressor factor (NSF) induced by the intravenous injection of hapten-conjugated syngeneic spleen cells...
  21. ncbi Disruption of the GluR2-NSF interaction protects primary hippocampal neurons from ischemic stress
    G S Ralph
    Division of Medicine, University of Bristol, Marlborough Street, Bristol, BS2 8HW
    Mol Cell Neurosci 17:662-70. 2001
    A specific interaction between the AMPA receptor subunits GluR2 and GluR3 and the fusion protein NSF has recently been identified...
  22. doi Changes in the de novo, salvage, and degradation pathways of pyrimidine nucleotides during tobacco shoot organogenesis
    Natalia Loukanina
    Plant Physiology Research Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta, T2N 1N4, Canada
    Plant Physiol Biochem 46:665-72. 2008
    ..metabolism was studied in tobacco callus cultured for 21days under shoot-forming (SF) and non-shoot-forming (NSF) conditions by following the metabolic fate of orotic acid, a precursor of the de novo pathway, and uridine and ..
  23. ncbi Fiber architecture of canine abdominal muscles
    Aladin M Boriek
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Appl Physiol (1985) 92:725-35. 2002
    ..Each fascicle contained between 20 and 30 muscle fibers. The mean length of nonspanning fibers (NSF) ranged from 2.8 +/- 0.3 cm in the IO to 4.3 +/- 0...
  24. ncbi Effect of bovine serum albumin on the extent of ortho rearrangement of N-(sulfooxy)-2-fluorenylacetamide and of enzymatically activated N-hydroxy-2-fluorenylacetamide and on the binding of reactive esters to nucleic acids
    R C Kolanczyk
    Research Service, Veterans Administration Medical Center, Minneapolis, Minnesota 55417
    Chem Res Toxicol 5:274-9. 1992
    ..BSA)-catalyzed ortho rearrangement of synthetic and enzymatically generated N-(sulfooxy)-2-fluorenylacetamide (NSF) to the O-sulfate esters on the binding of NSF to transfer ribonucleic acid (tRNA) and to deoxyribonucleic acid (..
  25. pmc Domains of alpha-SNAP required for the stimulation of exocytosis and for N-ethylmalemide-sensitive fusion protein (NSF) binding and activation
    R J Barnard
    Physiological Laboratory, University of Liverpool, United Kingdom
    Mol Biol Cell 7:693-701. 1996
    ..syntaxin, SNAP-25, and synaptobrevin leads to the recruitment of the N-ethylmaleimide-sensitive fusion protein (NSF)...
  26. pmc Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2
    M N Jagadish
    CSIRO, Division of Biomolecular Engineering, Parkville, Victoria, Australia
    Biochem J 317:945-54. 1996
    SNAP-25 (synaptosomal-associated protein 25), syntaxin and synaptobrevin are the three SNARE [soluble NSF attachment protein receptor (where NSF = N-ethylmaleimide-sensitive fusion protein)] proteins that form the core complex involved ..
  27. pmc A protocol for investigation of the effects of outdoor air pollution on stroke incidence, phenotypes and survival using the South London Stroke Register
    Ravi Maheswaran
    Public Health GIS Unit, School of Health and Related Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield S1 4DA, UK
    Int J Health Geogr 5:10. 2006
    ..It is an NHS health service and research priority, being identified as a target in Our Healthier Nation and the NSF for Older People for prevention and risk factor control and in the NHS Plan as a disease requiring intermediate ..
  28. ncbi A preclinical study to investigate the development of nephrogenic systemic fibrosis: a possible role for gadolinium-based contrast media
    Martin A Sieber
    Bayer Schering Pharma AG, Berlin, Germany
    Invest Radiol 43:65-75. 2008
    ..the administration of gadolinium (Gd)-based contrast agents and the occurrence of Nephrogenic Systemic Fibrosis (NSF), an acquired disorder marked by skin thickening and fibrosis occurring in patients with severe renal dysfunction...
  29. ncbi Association of N-ethylmaleimide sensitive fusion (NSF) protein and soluble NSF attachment proteins-alpha and -gamma with glucose transporter-4-containing vesicles in primary rat adipocytes
    C C Mastick
    Department of Cell Biology, Parke Davis Pharmaceutical Research Division, Warner Lambert Company, Ann Arbor, Michigan 48105, USA
    Endocrinology 138:2391-7. 1997
    To investigate the role of N-ethylmaleimide sensitive fusion protein (NSF) and soluble NSF attachment proteins (SNAP)-containing fusion complexes in glucose transporter-4 (GLUT4) membrane trafficking, the subcellular distributions of NSF,..
  30. ncbi A novel assay reveals a role for soluble N-ethylmaleimide-sensitive fusion attachment protein in mannose 6-phosphate receptor transport from endosomes to the trans Golgi network
    C Itin
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305 5307, USA
    J Biol Chem 272:27737-44. 1997
    Soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein (alpha-SNAP) is a soluble protein that enables the NSF ATPase to associate with membranes and facilitate membrane trafficking events...
  31. ncbi alpha-SNAP and NSF are required in a priming step during the human sperm acrosome reaction
    C N Tomes
    Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia IHEM CONICET, Facultad de Ciencias Medicas, CC 56, Universidad Nacional de Cuyo, 5500 Mendoza, Argentina
    Mol Hum Reprod 11:43-51. 2005
    ..in our laboratory, we have previously demonstrated requirements for Rab3A, N-ethylmaleimide-sensitive factor (NSF), several soluble NSF-attachment protein receptor (SNARE) proteins, and synaptotagmin VI in the human sperm AR...
  32. ncbi NSF- and SNARE-mediated membrane fusion is required for nuclear envelope formation and completion of nuclear pore complex assembly in Xenopus laevis egg extracts
    Tina Baur
    Institute of Biochemistry, ETH Zurich, CH 8093 Zurich, Switzerland
    J Cell Sci 120:2895-903. 2007
    ..fusion reactions, NE fusion in Xenopus laevis egg extracts is mediated by SNARE proteins that require activation by NSF. Antibodies against Xenopus NSF, depletion of NSF or the dominant-negative NSF(E329Q) variant specifically ..
  33. pmc Developing a health information infrastructure for Arizona
    R K Anderson
    Arizona Health Sciences Library, University of Arizona, Tucson 85724
    Bull Med Libr Assoc 82:396-400. 1994
    ..00 in National Library of Medicine/National Science Foundation (NLM/NSF) Connections Program funding to promote statewide collaboration in supporting UA's health sciences education and ..
  34. ncbi Origins of gene, genetic code, protein and life: comprehensive view of life systems from a GNC-SNS primitive genetic code hypothesis
    K Ikehara
    Department of Chemistry, Faculty of Science, Nara Women s University, Kita Uoya Nishi machi, Nara, Nara 630 8506, Japan
    J Biosci 27:165-86. 2002
    ..From the analysis of microbial genes, we have concluded that newly-born genes are products of nonstop frames (NSF) on antisense strands of microbial GC-rich genes [GC-NSF(a)] and from SNS repeating sequences [(SNS)n] similar to ..
  35. pmc Centers for Oceans and Human Health: a unified approach to the challenge of harmful algal blooms
    Deana L Erdner
    University of Texas Marine Science Institute, Port Aransas, TX 78373, USA
    Environ Health 7:S2. 2008
    ..HABs) are one focus of the national research initiatives on Oceans and Human Health (OHH) at NIEHS, NOAA and NSF. All of the OHH Centers, from the east coast to Hawaii, include one or more research projects devoted to studying ..
  36. doi Gadodiamide contrast agent 'activates' fibroblasts: a possible cause of nephrogenic systemic fibrosis
    M Edward
    Section of Dermatology, Division of Cancer Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK
    J Pathol 214:584-93. 2008
    Nephrogenic systemic fibrosis (NSF) is a fibrotic disease generating intense interest due to its recent discovery, and unknown cause...
  37. doi Nephrogenic systemic fibrosis associated with stromal and vascular calcification, report of two cases
    Jie Song
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Cutan Pathol 36:31-4. 2009
    Nephrogenic systemic fibrosis (NSF) is a systemic fibrosing disorder characterized by the development of large indurated plaques on the skin, primarily in patients with end-stage renal disease (ESRD)...
  38. pmc Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish
    Deborah M Kurrasch
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, USA
    Neural Dev 4:22. 2009
    ..The conserved function and spatial expression of hypothalamic peptides in vertebrates prompted us to search for critical neuroendocrine genes in newly hatched zebrafish larvae...
  39. ncbi Analysis of NSF mutants reveals residues involved in SNAP binding and ATPase stimulation
    William G C Horsnell
    The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, U K
    Biochemistry 41:5230-5. 2002
    N-Ethylmaleimide-sensitive fusion protein (NSF) and its yeast orthologue, Sec18, are cytoplasmic AAA(+) ATPases required for most intracellular membrane fusion events...
  40. ncbi NSF regulates membrane traffic along multiple pathways in Paramecium
    Roland Kissmehl
    University of Konstanz, Department of Biology, PO Box 5560, 78457 Konstanz, Germany
    J Cell Sci 115:3935-46. 2002
    N-ethylmaleimide (NEM)-sensitive factor (NSF), a regulator of soluble NSF attachment protein receptors (SNAREs), is required for vesicular transport in many eukaryotic cells...
  41. doi Risk of nephrogenic systemic fibrosis: evaluation of gadolinium chelate contrast agents at four American universities
    Rebecca Wertman
    School of Medicine, University of North Carolina at Chapel Hill, 101 Manning Dr, CB 7510, Chapel Hill, NC 27599 7510, USA
    Radiology 248:799-806. 2008
    To retrospectively determine the benchmark incidence of nephrogenic systemic fibrosis (NSF) related to the confirmed use of different gadolinium chelate contrast agents at four U.S. university tertiary care centers.
  42. doi Gadolinium exposure disrupts iron homeostasis in cultured cells
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    J Biol Inorg Chem 16:567-75. 2011
    Human exposure to gadolinium-based contrast agents can be complicated by nephrogenic systemic fibrosis (NSF)...
  43. ncbi Distinct roles for N-ethylmaleimide-sensitive fusion protein (NSF) suggested by the identification of a second Drosophila NSF homolog
    L Pallanck
    Laboratory of Genetics, University of Wisconsin, Madison 53706, USA
    J Biol Chem 270:18742-4. 1995
    The N-ethylmaleimide-sensitive fusion protein (NSF) is a cytoplasmic protein implicated in the fusion of intracellular transport vesicles with their target membranes...
  44. pmc A vacuolar v-t-SNARE complex, the predominant form in vivo and on isolated vacuoles, is disassembled and activated for docking and fusion
    C Ungermann
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755 3844, USA
    J Cell Biol 140:61-9. 1998
    Homotypic vacuole fusion in yeast requires Sec18p (N-ethylmaleimide-sensitive fusion protein [NSF]), Sec17p (soluble NSF attachment protein [alpha-SNAP]), and typical vesicle (v) and target membrane (t) SNAP receptors (SNAREs)...
  45. ncbi Membrane fusion of secretory vesicles of the sea urchin egg in the absence of NSF
    Tim Whalley
    Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 117:2345-56. 2004
    The role of cytosolic ATPases such as N-ethylmaleimide (NEM)-sensitive fusion protein (NSF) in membrane fusion is controversial...
  46. ncbi N-ethylmaleimide-sensitive factor: a redox sensor in exocytosis
    Charles J Lowenstein
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biol Chem 387:1377-83. 2006
    ..NO decreases exocytosis by regulating the activity of the N-ethylmaleimide-sensitive factor (NSF), a central component of the exocytic machinery...
  47. doi Balance of profibrotic and antifibrotic [corrected] signaling in nephrogenic systemic fibrosis skin lesions
    Gisela Schieren
    Department of Nephrology, University Hospital, Heinrich Heine University Dusseldorf, Germany
    Am J Kidney Dis 55:1040-9. 2010
    Nephrogenic systemic fibrosis (NSF) is an uncommon fibrotic disorder occurring after administration of linear gadolinium contrast agents in patients with severely decreased kidney function...
  48. ncbi Synaptic physiology and ultrastructure in comatose mutants define an in vivo role for NSF in neurotransmitter release
    F Kawasaki
    Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Neurosci 18:10241-9. 1998
    N-Ethylmaleimide-sensitive fusion protein (NSF) is a cytosolic protein thought to play a key role in vesicular transport in all eukaryotic cells...
  49. pmc Phosphorylation of SNAP-25 on serine-187 is induced by secretagogues in insulin-secreting cells, but is not correlated with insulin secretion
    Carmen Gonelle-Gispert
    Laboratoires de Recherche Louis Jeantet, Centre Medical Universitaire, rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Biochem J 368:223-32. 2002
    The tSNARE (the target-membrane soluble NSF-attachment protein receptor, where NSF is N -ethylmaleimide-sensitive fusion protein) synaptosomal-associated protein of 25 kDa (SNAP-25) is implicated in regulated insulin secretion...
  50. pmc Depletion of the ATPase NSF from Golgi membranes with hypo-S-nitrosylation of vasorelevant proteins in endothelial cells exposed to monocrotaline pyrrole
    Somshuvra Mukhopadhyay
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 295:H1943-55. 2008
    ..Golgi blockade characterized by the trapping of diverse vesicle tethers, soluble N-ethylmaleimide-sensitive factor (NSF)-attachment protein receptors (SNAREs), and soluble NSF-attachment proteins (SNAPs) in the Golgi; reduced ..
  51. pmc Endoscopic reconstruction of skull base defects with the nasal septal flap
    Ivan H El-Sayed
    Otolaryngic Division Minimally Invasive Skull Base Surgery, Department of Otolaryngology, University of California at San Francisco, San Francisco, California
    Skull Base 18:385-94. 2008
    ..A pedicled nasal septal flap (NSF) based on the posterior nasal septal artery has recently been developed for closure of these defects...
  52. doi Mechanism of NSF: New evidence challenging the prevailing theory
    Ben B Newton
    GE Healthcare, Medical Diagnostics Discovery Research, Amersham, UK
    J Magn Reson Imaging 30:1277-83. 2009
    Nephrogenic systemic fibrosis (NSF) has been associated with the administration of gadolinium-based contrast agents in patients with severely impaired renal function (SIRF), endstage renal disease (ESRD), or acute renal failure (ARF)...
  53. pmc Visual Arrestin 1 acts as a modulator for N-ethylmaleimide-sensitive factor in the photoreceptor synapse
    Shun Ping Huang
    Mary D Allen Laboratory for Vision Research, Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033 9224, USA
    J Neurosci 30:9381-91. 2010
    ..In this report, we discovered a novel synaptic interaction between Arr1 and N-ethylmaleimide-sensitive factor (NSF) that is enhanced in a dark environment when mouse photoreceptors are depolarized and the rate of exocytosis is ..
  54. ncbi Role of SNARE's in the GLUT4 translocation response to insulin in adipose cells and muscle
    J F St-Denis
    Experimental Diabetes, Metabolism, and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Basic Clin Physiol Pharmacol 9:153-65. 1998
    ..A general hypothesis called the SNARE hypothesis (soluble NSF attachment protein receptors where NSF stands for N-ethylmaleimide-sensitive fusion protein) postulates that the ..
  55. pmc A screen for dominant negative mutants of SEC18 reveals a role for the AAA protein consensus sequence in ATP hydrolysis
    G J Steel
    The Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Mol Biol Cell 11:1345-56. 2000
    ..This involved random mutagenesis of a GAL1-regulated SEC18 yeast expression plasmid...
  56. ncbi A model to assess the cost effectiveness of statins in achieving the UK National Service Framework target cholesterol levels
    Koo Wilson
    Pfizer Ltd, Walton Oaks, Tadworth, Surrey, UK
    Pharmacoeconomics 21:1-11. 2003
    Coronary heart disease (CHD) is a public health priority in the UK. The National Service Framework (NSF) has set standards for the prevention, diagnosis and treatment of CHD, which include the use of cholesterol-lowering agents aimed at ..
  57. ncbi Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking
    Jennifer M Bomberger
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 280:9297-307. 2005
    ..e. degradation of the receptor complex). Co-expression of N-ethylmaleimide-sensitive factor (NSF) with the CRLR-RAMP3 complex, but not CRLR-RAMP1 or CRLR-RAMP2 complex, altered receptor trafficking to a recycling ..
  58. doi Nephrogenic systemic fibrosis: late skin manifestations
    Nannie Bangsgaard
    Department of Dermatology, University Hospital of Copenhagen Gentofte, Niels Andersens Vej 65, DK 2900 Hellerup, Denmark
    Arch Dermatol 145:183-7. 2009
    Nephrogenic systemic fibrosis (NSF) is a serious disease that occurs in patients with severe renal disease and is believed to be caused by gadolinium-containing contrast agents...
  59. pmc Docking of yeast vacuoles is catalyzed by the Ras-like GTPase Ypt7p after symmetric priming by Sec18p (NSF)
    A Mayer
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755 3844, USA
    J Cell Biol 136:307-17. 1997
    ..Vacuole fusion has been reconstituted in vitro and may be used as a model for an NSF-dependent reaction of priming, docking, and fusion...
  60. ncbi The VPS4 gene is involved in protein transport out of a yeast pre-vacuolar endosome-like compartment
    M Finken-Eigen
    Biologisch Medizinisches Forschungszentrum, Heinrich Heine Universitat Dusseldorf, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Curr Genet 31:469-80. 1997
    ..Based on the pleiotropic phenotype of the vps4 mutants and on the sequence homology to NSF/Sec18p, we propose that the VPS4 gene product is required for efficient transport out of the pre-vacuolar endosome-..
  61. ncbi The evolution of the conserved ATPase domain (CAD): reconstructing the history of an ancient protein module
    J C Swaffield
    Department of Genetics, North Carolina State University, P O Box 7614, Raleigh, NC 27695 7614, USA
    J Mol Evol 45:549-63. 1997
    ..events that lead to the establishment of different functional AAA proteins, including proteasomal regulatory, NSF/Sec, and Pas proteins...
  62. ncbi Folding intermediates of SNARE complex assembly
    K M Fiebig
    The Howard Hughes Medical Institute, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Nat Struct Biol 6:117-23. 1999
    SNARE (soluble NSF attachment protein receptor) proteins assemble into a stable complex essential for vesicle-membrane fusion...
  63. pmc Putative fusogenic activity of NSF is restricted to a lipid mixture whose coalescence is also triggered by other factors
    B Brugger
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    EMBO J 19:1272-8. 2000
    It has recently been reported that N-ethylmaleimide-sensitive fusion ATPase (NSF) can fuse protein-free liposomes containing substantial amounts of 1,2-dioleoylphosphatidylserine (DOPS) and 1, 2-dioleoyl-phosphatidyl-ethanolamine (DOPE) (..
  64. pmc Nissui glucose fermentative gram-negative rod identification system EB-20 gives a unique profile for typical non-sorbitol-fermenting Escherichia coli O157:H7
    H Kodaka
    Department of Microbiology, School of Medicine, Toho University, Otaku, Tokyo 143 8540, Japan
    J Clin Microbiol 42:354-8. 2004
    The 98 non-sorbitol-fermenting (NSF) Escherichia coli O157:H7 strains identified on a Nissui glucose fermentative gram-negative rod identification system (EB-20) gave a unique biochemical profile number that was not detected in 85 ..
  65. ncbi A ubiquitous membrane fusion protein alpha SNAP: a potential therapeutic target for cancer, diabetes and neurological disorders?
    Alexandra V Andreeva
    University of Illinois at Chicago, Department of Pharmacology, 909 S Wolcott Avenue, Chicago, IL, USA
    Expert Opin Ther Targets 10:723-33. 2006
    Alpha soluble NSF attachment protein (alphaSNAP) is a ubiquitous and indispensable component of membrane fusion machinery. Deletion of alphaSNAP is embryonically lethal...
  66. ncbi C-terminal modification is required for GABARAP-mediated GABA(A) receptor trafficking
    Zi Wei Chen
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1735, USA
    J Neurosci 27:6655-63. 2007
    ..In addition, the distribution of NSF (N-ethylmaleimide-sensitive factor) was affected in GABARAP(G116A)-expressing neurons...
  67. ncbi [Recent progress in membrane dynamics research by two-photon microscopy]
    Tomomi Nemoto
    National Institutes of Natural Sciences, National Institute for Physiological Sciences, Okazaki City, Japan
    Yakugaku Zasshi 128:513-20. 2008
    ..Further exploration has revealed dynamics and physiological roles of actin cytoskeleton, and soluble NSF attachment receptor (SNARE) proteins...
  68. doi Gene expression patterns of hippocampus and cerebral cortex of senescence-accelerated mouse treated with Huang-Lian-Jie-Du decoction
    Yue Zheng
    Department of Neuroimmunopharmacology, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China
    Neurosci Lett 439:119-24. 2008
    ..Dip3b, Acrbp), nucleic acid metabolism (Fhit, Itm2c, Cstf2t, Ddx3x, Ercc5, Pcgfr6), energy metabolism (Stub1, Uqcr, Nsf), immune response (C1qb), regulation of transcription (D1ertd161e, Gcn5l2, Ssu72), transporter (Slc17a7, mt-Co1), ..
  69. ncbi Gadolinium-associated nephrogenic systemic fibrosis: the need for nephrologists' awareness
    Caterina Canavese
    Nephrology and Transplantation, Department of Clinical and Experimental Medicine, and International Research Centre Autoimmune Diseases, Amedeo Avogadro University, Maggiore Hospital, Novara, Italy
    J Nephrol 21:324-36. 2008
    Nephrogenic systemic fibrosis (NSF) / nephrogenic fibrosing dermopathy (NFD) is a recently described disease, occurring only in patients with variable degrees of renal failure (RF) previously exposed to gadolinium-based contrast agents (..
  70. ncbi [Physicochemical water quality index, a management tool for tropical-flooding lagoons]
    Ana Gabriela Pérez-Castillo
    Escuela de Quimica, Universidad de Costa Rica, 2060 San Jose, Costa Rica
    Rev Biol Trop 56:1905-18. 2008
    ..adjustment values were based on "weights" defined in the National Sanitation Foundation Water quality Index (ICA-NSF)...
  71. ncbi [Nephrogenic systemic fibrosis]
    Astrid Breitschaft
    Institut fur Klinische Pharmakologie und Toxikologie, Charite Campus Benjamin Franklin, Garystr 5, 14195 Berlin
    Med Monatsschr Pharm 32:377-82. 2009
    ..Nephrogenic systemic fibrosis (NSF) is a disabling and potentially fatal disease characterized by thickening and hardening of the skin, especially of ..
  72. doi Membrane trafficking in protozoa SNARE proteins, H+-ATPase, actin, and other key players in ciliates
    Helmut Plattner
    Department of Biology, University of Konstanz, Konstanz, Germany
    Int Rev Cell Mol Biol 280:79-184. 2010
    ..They include NSF (N-ethylmaleimide sensitive factor), SNAREs (soluble NSF attachment protein [SNAP] receptors), the H(+)-ATPase (V-..
  73. doi Interactions between N-ethylmaleimide-sensitive factor and GluR2 in the nucleus accumbens contribute to the expression of locomotor sensitization to cocaine
    Hai Feng Lu
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China, Key Laboratory of Neurological Diseases HUST, Ministry of Education of China, Wuhan, Hubei 430030, China, and The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, Hubei 430030, China
    J Neurosci 34:3493-508. 2014
    ..that the expression of behavioral sensitization was negatively controlled by N-ethylmaleimide-sensitive factor (NSF)-GluR2 interactions in the NAc...
  74. doi Hyperforin alleviates mood deficits of adult rats suffered from early separation
    Minghui Zhu
    School of Medicine, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Tumor Microenvironment and Neuro vascular Regulation, Nankai University, Tianjin 300071, China
    Neurosci Lett 608:1-5. 2015
    ..After separation, adult rats were evaluated by using the open field test (OFT), novelty suppressed feeding test (NSF) and forced swimming test (FST)...
  75. pmc Molecular Composition of Plant Vacuoles: Important but Less Understood Regulations and Roles of Tonoplast Lipids
    Chunhua Zhang
    Center for Plant Cell Biology and Department of Botany and Plant Sciences, University of California, 900 University Ave, Riverside, CA 92521, USA
    Plants (Basel) 4:320-33. 2015
    ..trafficking; such proteins include Rab GTPase signaling proteins; cargo recognition receptors; and SNAREs (Soluble NSF Attachment Protein Receptors) that are involved in membrane fusion...
  76. pmc Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases
    Irene Sambri
    Telethon Institute of Genetics and Medicine TIGEM, Naples, Italy
    EMBO Mol Med 9:112-132. 2017
    ..the availability of both α-synuclein and CSPα at nerve terminals strongly decreases, thus inhibiting soluble NSF attachment receptor (SNARE) complex assembly and synaptic vesicle recycling...
  77. ncbi Interactions Between SNAP-25 and Synaptotagmin-1 Are Involved in Vesicle Priming, Clamping Spontaneous and Stimulating Evoked Neurotransmission
    Melanie Schupp
    Neurosecretion Group, Department of Neuroscience and Pharmacology, University of Copenhagen, DK 2200 Copenhagen, Denmark and
    J Neurosci 36:11865-11880. 2016
    Whether interactions between synaptotagmin-1 (syt-1) and the soluble NSF attachment protein receptors (SNAREs) are required during neurotransmission is debated...
  78. pmc Monitoring the compliance of the academic enterprise with the Fair Labor Standards Act
    Adriana Bankston
    The Future of Research, Inc, 848 Brockton Avenue, Abington, MA, USA
    F1000Res 5:2690. 2016
    ..efforts (checking university websites and contacting HR departments) to uncover what institutions in the 2014 NSF Survey of Graduate Students and Postdoctorates in Science and Engineering are doing to comply with the FLSA ruling ..
  79. ncbi Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein
    C U Lenzen
    Department of Structural Biology, Stanford University School of Medicine, California 94305, USA
    Cell 94:525-36. 1998
    N-ethylmaleimide-sensitive fusion protein (NSF) is a cytosolic ATPase required for many intracellular vesicle fusion reactions...
  80. pmc Molecular aspects of the endocytic pathway
    M J Clague
    Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, U K
    Biochem J 336:271-82. 1998
    ..examples include vesicle coat proteins, rabs (small GTPases) and soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein (SNAP) receptors (SNAREs)...
  81. ncbi Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons
    Mako Narisawa-Saito
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    J Biol Chem 277:40901-10. 2002
    ..These results reveal a novel role of BDNF in regulating the surface expression of AMPA receptors through a GluR2-NSF interaction.
  82. ncbi Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation
    Scott Ficarro
    Department of Chmeistry, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:11579-89. 2003
    ..Among the protein targets, valosin-containing protein (VCP), a homolog of the SNARE-interacting protein NSF, and two members of the A kinase-anchoring protein (AKAP) family were found to be tyrosine phosphorylated during ..
  83. ncbi Older people as health service consumers: background to a study
    Jenny Bentley
    Florence Nightingale School of Nursing and Midwifery, King s College, London, UK
    Br J Community Nurs 8:36-43. 2003
    ..The national service framework (NSF) for older people (DH, 2001a) highlights the need to listen to older people, help them make informed choices and ..
  84. ncbi Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling
    Kishalay Hoare
    University of Florida Shands Cancer Center, 1600 SW Archer Road, Gainesville, FL 32610 0232, USA
    Oncogene 22:3562-77. 2003
    ..Kos1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition...
  85. ncbi Current trends in brain-computer interface research at the Neil Squire Foundation
    Gary E Birch
    Neil Squire Foundation, Burnaby, BC V5M 3Z3, Canada
    IEEE Trans Neural Syst Rehabil Eng 11:123-6. 2003
    The Neil Squire Foundation (NSF) is a Canadian nonprofit organization whose purpose is to create opportunities for independence for individuals who have significant physical disabilities...
  86. ncbi SNAP-25 Ser187 does not mediate phorbol ester enhancement of hippocampal synaptic transmission
    Michael F A Finley
    Howard Hughes Medical Institute, Stanford University School of Medicine, Beckman Center B003, Stanford, CA 94305, USA
    Neuropharmacology 45:857-62. 2003
    ..potential downstream target of PKC in the presynaptic terminal is the soluble N-ethylmaleimide sensitive factor (NSF) attachment protein receptor (SNARE) SNAP-25, which has a PKC phosphorylation site in its C-terminal coil centered ..
  87. ncbi Coronary heart disease: an update on progress of the NSF
    Shelley Peacock
    Florence Nightingale School of Nursing and Midwifery, King s College London
    Br J Community Nurs 10:180-4. 2005
    ..CHD was among the first conditions to be addressed by a national service framework (NSF), published in 2000...
  88. ncbi Prevalence and correlates of restless legs syndrome: results from the 2005 National Sleep Foundation Poll
    Barbara Phillips
    Fifth Floor, Kentucky Clinic, Division of Pulmonary, Critical Care and Sleep Medicine, University of Kentucky College of Medicine, 800 Rose St, Lexingon, KY 40536 0028, USA
    Chest 129:76-80. 2006
    ..the prevalence and correlates of restless legs syndrome (RLS) symptoms in the 2005 National Sleep Foundation (NSF) Sleep in America 2005 Poll...
  89. pmc Cellular functions of NSF: not just SNAPs and SNAREs
    Chunxia Zhao
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, 741 South Limestone, BBSRB B261, Lexington, KY 40536, USA
    FEBS Lett 581:2140-9. 2007
    N-ethylmaleimide sensitive factor (NSF) is an ATPases associated with various cellular activities protein (AAA), broadly required for intracellular membrane fusion...
  90. ncbi Update on radiological imaging of renal cell carcinoma
    Deirdre M Coll
    Department of Radiology, The Mount Sinai Medical Center, New York, NY, USA
    BJU Int 99:1217-22. 2007
    ..also be taken in these patients, given the recent studies raising the association of gadolinium-based compounds and NSF. There have been dramatic improvements in renal imaging over the last decade, offering better resolution, shorter ..
  91. doi Gadolinium and nephrogenic systemic fibrosis: association or causation
    Jagadeesh Kurtkoti
    Department of Nephrology, Gold Coast Hospital, Gold Coast, Queensland, Australia
    Nephrology (Carlton) 13:235-41. 2008
    ..because of increasing reports of nephrogenic fibrosing dermopathy (NFD)/nephrogenic systemic fibrosis (NSF), associated with the exposure to certain gadolinium-containing contrast agents...
  92. doi Nephrogenic systemic fibrosis: a sufficient reason to avoid gadolinium-based contrast in all patients with renal impairment?
    Michelle Willicombe
    The Centre for Nephrology, The Royal Free and University College Medical School, London, United Kingdom
    Semin Dial 21:140-1. 2008
    Nephrogenic systemic fibrosis (NSF) was recently linked to gadolinium-based contrast (GBC) exposure in patients with renal failure. As result, the U.S...
  93. ncbi Toxicity of MRI and CT contrast agents
    Kendra M Hasebroock
    University of Colorado, Anschutz Medical Center, Cancer Center Animal MRI PET CT Core, Department of Anesthesiology and Radiology, Aurora, CO 80045, USA
    Expert Opin Drug Metab Toxicol 5:403-16. 2009
    ..life-threatening contrast-induced nephropathy (CIN) is associated with CT and nephrogenic systemic fibrosis (NSF) with MRI contrast agents. CIN is defined as an acute decline in renal functions (serum creatinine increase > 0...
  94. doi Role of syntaxin 18 in the organization of endoplasmic reticulum subdomains
    Takayuki Iinuma
    School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192 0392, Japan
    J Cell Sci 122:1680-90. 2009
    ..In the present study, we show that syntaxin 18, a SNAP (soluble NSF attachment protein) receptor localized in the ER, is important for the organization of two ER subdomains, smooth/..
  95. doi Screening patients to assess renal function before administering gadolinium chelates: assessment of the Choyke questionnaire
    Brena F Sena
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    AJR Am J Roentgenol 195:424-8. 2010
    ..the efficacy of using the Choyke questionnaire to stratify the potential risk for nephrogenic systemic fibrosis (NSF) before a gadolinium-enhanced MRI examination and to compare the economic impact of such an approach with universal ..
  96. doi Nephrogenic systemic fibrosis: review of 370 biopsy-confirmed cases
    Zhitong Zou
    Department of Radiology, Weill Medical College of Cornell University, New York, New York, USA
    JACC Cardiovasc Imaging 4:1206-16. 2011
    Discovery of an association between gadolinium-based contrast agents (GBCAs) and nephrogenic systemic fibrosis (NSF) has led to less use of GBCA-enhanced magnetic resonance imaging in dialysis patients and patients with severe renal ..
  97. pmc Munc18-1 controls SNARE protein complex assembly during human sperm acrosomal exocytosis
    Facundo Rodríguez
    Laboratorio de Biologia Celular y Molecular, Instituto de Histología y Embriología Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo, 5500 Mendoza, Argentina
    J Biol Chem 287:43825-39. 2012
    ..recombinant Munc18-1 blocked secretion by sequestering monomeric syntaxin, an effect that was rescued by α-soluble NSF attachment protein...
  98. ncbi 4-mer hyaluronan oligosaccharides stimulate inflammation response in synovial fibroblasts in part via TAK-1 and in part via p38-MAPK
    G M Campo
    Department of Biomedical Sciences and Morphological and Functional Images, School of Medicine, University of Messina, Policlinico Universitario, Torre Biologica, 5 piano, Via C Valeria 98125 Messina, Italy
    Curr Med Chem 20:1162-72. 2013
    ..HA oligosaccharide-induced inflammatory response in mouse synovial fibroblasts obtained from normal DBA/J1 mice (NSF) and from mice subjected to collagen-induced arthritis (CIA)...
  99. pmc Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk
    Fergus J Couch
    Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
    PLoS Genet 9:e1003212. 2013
    ..Such differences in risk may have important implications for risk prediction and clinical management for BRCA1 carriers...
  100. pmc An essential and NSF independent role for α-SNAP in store-operated calcium entry
    Yong Miao
    Pathology and Immunology, Washington University School of Medicine, St Louis, United States
    elife 2:e00802. 2013
    ..This role for α-SNAP is direct and independent of its known activity in NSF dependent SNARE complex disassembly...
  101. doi Research Ethics Education in the STEM Disciplines: The Promises and Challenges of a Gaming Approach
    Adam Briggle
    Department of Philosophy and Religion, University of North Texas, 1155 Union Circle 310920, Denton, TX, 76203 5017, USA
    Sci Eng Ethics 22:237-50. 2016
    ..Recent years have witnessed a turn toward the use of games in this context. Drawing from two NSF-funded grants (one completed and one on-going), this paper takes a critical look at the use of games in ethics and ..

Research Grants68

  1. PETER D CARAVAN; Fiscal Year: 2016
    ..Recently, however, Gd-based agents have been implicated in nephrogenic systemic fibrosis (NSF), a debilitating disorder that affects patients with renal insufficiency...
  2. Preclinical Efficacy And Safety Evaluation Of Graphene Nanoparticle-based Magneti
    Balaji Sitharaman; Fiscal Year: 2013
    ..with advanced renal failure, these CAs have been linked to the onset of the disease nephrogenic systemic fibrosis (NSF)...
  3. Role of toll like receptors (TLRs)in Gd contrast agent induced skin fibrosis
    Sergio A Jimenez; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Nephrogenic Systemic Fibrosis (NSF) is a rare condition occurring in a small subset of patients with renal insufficiency following exposure to Gadolinium based contrast agents (GdBCA)...
  4. Fourth Annual Symposium on Nephrogenic Systemic Fibrosis and Gadolinium Based Con
    Ali Abu Alfa; Fiscal Year: 2010
    ..This meeting will discuss Nephrogenic Systemic Fibrosis (NSF), a rare skin disorder known to be highly associated with, and very likely triggered by, gadolinium based magnetic ..
  5. Nephrogenic Systemic Fibrosis (NSF): A Rodent Model for Therapeutic Intervention
    Wassana Yantasee; Fiscal Year: 2013
    ..provided by applicant): This R01 proposal focuses on a new emerging disease, Nephrogenic Systemic Fibrosis (NSF), which affects patients with severe renal impairment...
  6. Research for Adverse Drug-Events and Reports
    DENNIS PAUL WEST; Fiscal Year: 2010
    Nephrogenic Systemic Fibrosis (NSF) is a disabling dermatologic adverse drug reaction associated with Gadolinium Containing Chelating Agents (GCCAs)...
  7. Non-Contrast-Enhanced Peripheral MR Angiography
    Vivian S Lee; Fiscal Year: 2013
    ..Recently, gadolinium administration has been linked to the development of nephrogenic systemic fibrosis (NSF) in patients with renal insufficiency...
  8. Hydroxypyridonate Gd Complexes: MRI Agents
    Kenneth N Raymond; Fiscal Year: 2013
    ..used are particularly problematic in light of the recent research suggesting that nephrogenic systemic fibrosis (NSF, alternately NFD) is caused by release of Gd from the contrast agent before it clears through the kidneys...
  9. COLLOIDAL IRON-OXIDE NANOBEACONS FOR THERANOSTIC USE IN ATHEROSCLEROSIS
    Gregory M Lanza; Fiscal Year: 2010
    ..With recent concerns about the use of gadolinium and its relationship to Nephrogenic Systemic Fibrosis (NSF), alternative theranostic approaches need to be developed...
  10. Non-Contrast Magnetic Resonance Angiography of Peripheral Vascular Disease
    Robert R Edelman; Fiscal Year: 2013
    ..one must exercise caution in using CE-MRA because of concerns about the risks of nephrogenic systemic fibrosis (NSF), a serious and potentially lethal disorder...
  11. Simon C Watkins; Fiscal Year: 2016
    ..has a strong basic science component that addresses the Cell and Molecular Biology of CF, and is supported by NIH, NSF and Cystic Fibrosis Foundation (CFF) grants...
  12. Motion-compensated PC HYPR VIPR for Renal MR Angiography
    Oliver Wieben; Fiscal Year: 2012
    ..be excluded from standard MRA exams because of the potential development of nephrogenic systemic fibrosis (NSF) could still be diagnosed with this approach...
  13. Innovations Involving Balanced Steady State Free Precession MRI
    JAMAL JON DERAKHSHAN; Fiscal Year: 2010
    ..revelation of the associated risk of the progressive and life-threatening disease Nephrogenic Systemic Fibrosis (NSF)...
  14. Molecular Mechanism of Renin Release, Role of SNAREs
    Mariela Mendez; Fiscal Year: 2011
    ..In most cells, exocytosis is mediated by "soluble NSF attachment protein receptors" (SNAREs)...
  15. Frederick M Hughson; Fiscal Year: 2016
    ..Vesicle docking and fusion requires, in addition to soluble NSF attachment protein receptors (SNAREs), multisubunit tethering complexes (MTCs)...
  16. ANDREI IVANOVICH IVANOV; Fiscal Year: 2014
    ..of proteins regulating vesicle fusion with the plasma membrane, namely the N-ethylmaleimide sensitive factor (NSF), soluble NSF receptors (SNAREs) and NSF- attachment protein (1SNAP)...
  17. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
    ..of ~20 standing (Assistant to Full) professors, and 7 research professors, all of who are funded by NIH or NSF, and are conducting active research in biochemistry, cell, molecular, and developmental biology...
  18. Regulation and Neural Function of Atypical PKC
    Todd C Sacktor; Fiscal Year: 2011
    ..AMPA receptors (AMPARs) through interactions between the AMPAR GluR2 subunit and the trafficking protein NSF. We will examine whether this potentiation is through increased exocytosis and/or decreased endocytosis of ..
  19. Mechanisms of fusion and transmitter release in neurosecretion
    Manfred Lindau; Fiscal Year: 2012
    ..The SNARE (Soluble NSF Attachment REceptor) complex, composed of the proteins synaptobrevin, syntaxin and SNAP-25 forming a coiled coil, a ..
  20. Ubiquitin and Cell Cycle Regulation of Golgi Membrane Dynamics
    Yanzhuang Wang; Fiscal Year: 2013
    ..Reassembly is mediated by two ATPases (NSF and p97) that fuse the membranes...
  21. Todd C Sacktor; Fiscal Year: 2016
    ..AMPA receptors (AMPARs) through interactions between the AMPAR GluR2 subunit and the trafficking protein NSF. We will examine whether this potentiation is through increased exocytosis and/or decreased endocytosis of ..
  22. Christopher Peters; Fiscal Year: 2014
    ..This fundamental process is supposed to be catalyzed by specific proteins termed SNAREs (soluble NSF attachment protein receptors)...
  23. DAVID LEWIS BEVERIDGE; Fiscal Year: 2015
    ..All faculty members except our two new Assistant Professors have extramurally funded grants from NIH, NSF and other funding sources for their research programs...
  24. Using a MALDI-TOF System for SNP Analysis
    Nadereh Jafari; Fiscal Year: 2010
    ..system from Sequenom is necessary to fill this gap and to permit the efficient and timely completion of NIH- and NSF-funded projects focusing on a broad spectrum of diseases such as heart failure, hyperglycemia and adverse pregnancy ..
  25. Developing and Improving the UAB Gnotobiotic Facility.
    SAMUEL CORBIN CARTNER; Fiscal Year: 2013
    ..To meet investigators needs we propose to renovate 1,734 nsf of animal facility space currently used for storage, animal housing and procedure space to accommodate state-of-the-..
  26. A Test of Leptin's Central Function in Zebrafish
    RICHARD LYLE LONDRAVILLE; Fiscal Year: 2012
    ..been successful in attracting underrepresented students into their research programs, and the PI is a member of an NSF-sponsored project dedicated to increasing representation of women and minorities in STEM disciplines (Project IDEAL)..
  27. The Role of Actin Remodeling in Membrane Fusion Microdomains
    William Wickner; Fiscal Year: 2007
    ..Fusion occurs by a highly complex, and conserved, pathway of SNAREs, Ypt/Rabs, their effectors and chaperones (NSF/SNAP and SM proteins), phosphoinositides, and actin...
  28. Katarzyna Slowinska; Fiscal Year: 2015
    ..This SC-3 support, if awarded, will increase the PI's research output and improve competitiveness for major grant support such as NSF and NIH-RO1 type grants.
  29. Todd R Miller; Fiscal Year: 2016
    ..This proposal leverages the support of other ongoing projects including the NSF Undergraduate Research in Biology and Mathematics (UBM) program at the University of Wisconsin, Milwaukee (UWM), ..
  30. Golgi Blockade in Pulmonary Hypertension
    Pravin B Sehgal; Fiscal Year: 2012
    ..tethers, SNAREs and SNAPs in the Golgi and subcellular mislocalization of N-ethylmaleimide sensitive factor (NSF), and of cargo such as eNOS and vasorelevant growth factor recetors (SNAREing pulmonary hypertension), Distal ..
  31. Stoichiometry and Architecture of the Vesicle Fusion Machine in PC-12 Cells
    JAMES WEISSHAAR; Fiscal Year: 2009
    ..Key components include the SNARE (soluble NSF attachment receptor) proteins syntaxin (Syx), SNAP-25, and synaptobrevin (Syb), and the Ca2+ sensor synaptotagmin (..
  32. Exocytosis and Vascular Inflammation
    Charles Lowenstein; Fiscal Year: 2007
    ..Several families of proteins regulate exocytosis, including N-ethylmaleimide sensitive factor (NSF), soluble NSF attachment protein receptors (SNAREs), rab GTPases, and Munc...
  33. Janet M Oliver; Fiscal Year: 2014
    ..Center (UNMCC) was recognized as one of 60 NCI-designated Cancer Centers in the nation;UNM's application to NSF for an Integrated Graduate Education and Research Traineeship (IGERT) program in Nanoscience and Microsystems (NSMS)..
  34. HAREL ZEEV SHOUVAL; Fiscal Year: 2016
    ..Because an important goal for NSF is to integrate research and education, we will train a diverse pool of students...
  35. Eric Halgren; Fiscal Year: 2016
    ..th research will be incorporated into teaching modules that could be used by K-12 teachers, in conjunction with the NSF sponsored Science of Learning Center at UCSD co-directed by Sejnowski...
  36. Bingren Hu; Fiscal Year: 2016
    ..to disruption of the autophagy pathway via irreversible inactivation of N-ethylmaleimide-sensitive fusion protein (NSF) ATPase, resulting in multiple organelle damage/failure and delayed neuronal death...
  37. Photonic Crystal Surfaces for Label-Free Detection and Fluorescence Amplification
    LILA OTT VODKIN; Fiscal Year: 2012
    ..will enable collaboration between faculty in Electrical Engineering, who developed the PC and EF technology under NSF funding, and faculty in Crop Science, who manage the NSF Soybean Functional Genomics Center, thus allowing the ..
  38. Genetic Dissection of Age-dependent Neuroprotection Mechanisms in Drosophila
    BARRY S GANETZKY; Fiscal Year: 2013
    ..We propose genetic and biochemical experiments to test and refine this hypothesis. comt, which encodes NSF-1 (N-ethyl- maleimide sensitive fusion protein), exhibits a deficit in lysosomes and accumulation of ubiquitinated ..
  39. Scott J Russo; Fiscal Year: 2014
    ..tests (SPT), decreased time grooming on the splash test, increased latency to feed on novelty suppressed feeding (NSF), and increased serum corticosterone levels...
  40. Cheryl L Willman; Fiscal Year: 2016
    ..Discovery {U54MH084690), one of 10 NIH-funded National Centers for Systems Biology (P50GM085273), one of 4 NSF/NCI Centers for Integrative Nanoscience and Microsystems Training (DGE0504276), one of 20 LLS Specialized Centers ..
  41. Cellular Pharmacology of Kappa Opiod Receptor
    Lee Yuan Liu-Chen; Fiscal Year: 2013
    ..The hypothesis that GEC1 enhances KOPR expression by enhancing ATPase activity of NSF, but not by membrane association by lipid conjugation will be tested...
  42. CRNS: Model of hippocampal-amygdala interaction: Implications for PTSD
    Catherine E Myers; Fiscal Year: 2012
    In response to NSF/NIH CRCNS (NS-08-008), we propose a new collaborative project to develop a computational model of the interaction of hippocampus, amygdala, and ventromedial prefrontal cortex in conditioning, extinction, and contextual ..
  43. CRCNS: Modeling Activation of CaMKII in Spines
    Terrence J Sejnowski; Fiscal Year: 2013
    ..The syntax for doing this will be published, and taught in the regular workshops on MCell sponsored by NSF. The proposal has medical significance...
  44. Biosensing in electrochemically controlled nano-junctions
    Krzysztof Slowinski; Fiscal Year: 2013
    ..of a four year funding requested in this application should allow PI to become more competitive for major NIH/NSF grant support...
  45. Cellular and Molecular Mechanisms in Periventricular Heterotopia
    Volney L Sheen; Fiscal Year: 2013
    ..Alpha-SNAP (encoded by Napa) is a NSF attachment protein, involved in SNAP receptor-mediated vesicle fusion...
  46. Nanoprobe for High Resolution Hard X-ray Fluorescence Microscopy
    Gayle E Woloschak; Fiscal Year: 2010
    ..While we have listed NIH funded investigators, we have an additional list of NSF- and DOE-funded investigators who would also be interested in using the instrument for studies of metal content in ..
  47. Genetic Control of Microglia and Neural Macrophages
    William S Talbot; Fiscal Year: 2013
    ..are increased and strongly activated in a mutant recovered in our previous screens for myelination mutants, nsf. Interestingly, a drug that blocks activation of microglia and macrophages ameliorates the phenotype of nsf mutants,..
  48. Community Structure and the Epidemiology of Hantavirus in Southern Chile
    Claudia Munoz-Zanzi; Fiscal Year: 2013
    ..This research will be done as an extension of NSF-EID Grant No...
  49. PATRICIA MARIE LENHART; Fiscal Year: 2014
    ..known for its ability to alter GPCR recycling to the plasma membrane through a PDZ motif-dependent association with NSF. GPER1 is a novel cardioprotective estrogen-binding GPCR that is present in increased levels in females and in CVD...
  50. Robert O Messing; Fiscal Year: 2016
    ..PKC[unreadable] also phosphorylates the N-ethylmaleimide sensitive factor (NSF), at Ser-460 and Thr-461, which stimulates removal of GABAA receptors from synapses...
  51. Eric J Friedman; Fiscal Year: 2015
    ..Lastly, while at least 75% of the PI's time will be spent on this project, the PI is also involved in an NSF-funded project to develop new methods for analyzing networks, which will mesh well with this project and provide ..
  52. Peter W Nathanielsz; Fiscal Year: 2014
    ..We have received NHLBI, NICHD, NEI, NINCDS, NIA, NIMH, NIDDK and NSF funding for NHP studies and have extensive collaborations...
  53. STEPHEN RANDAL VOSS; Fiscal Year: 2016
    ..A dual NIH-NSF funding model is proposed where costs associated with the maintenance and distribution of axoloti stocks will be ..
  54. Integrating and Evaluating the Modeling Applied to Problem Solving Pedagogy
    David E Pritchard; Fiscal Year: 2010
    ..the MIT exam problems and the Mechanics Baseline Test into a new expert inventory (that we're developing with NSF support)? [unreadable] How effective are the instructional materials that we are developing to teach MAPS pedagogy? ..
  55. University of New Mexico Health Sciences Center Animal Resource Facility Improvem
    KEVIN C O'HAIR; Fiscal Year: 2012
    ..support purchase of a new tunnel washer, 13 ventilated mouse racks and associated renovation of 2,197 gsf / 2,197 nsf to support installation of this equipment at the University of New Mexico (UNM) Health Sciences Center (HSC) Animal ..
  56. Center for Subtropical & Tropical Oceans & Human Health Research in Marine Scienc
    LORA ELDERKIN FLEMING; Fiscal Year: 2010
    ..on several decades of collaborative and interdisciplinary research, education and training to address the new NIEHS-NSF research initiative in Oceans and Human Health...
  57. GENOMIC DELETION AND DUPLICATION COVERAGE IN DROSOPHILA
    Kevin R Cook; Fiscal Year: 2010
    ..At the Bloomington Drosophila Stock Center, the NIH- and NSF-sponsored, comprehensive repository for fly genetic strains, we have worked to improve deletions and duplication ..
  58. Request for support for the Second International Symposium: Facing the Challenges
    ALEXANDER SIMEON RAIKHEL; Fiscal Year: 2012
    ..biologists who work on arthropod vectors of human and plant diseases (funding for the latter coming from a separate NSF proposal) thereby allowing participants to find commonalities in problems and approaches in vector biology...
  59. Jeannie S Huang; Fiscal Year: 2016
    ..Initial analysis of collected video data will be performed using our NSF-funded automated facial expression recognition system (CERT: Bartlett &Littlewort), and electrodermal activity (..
  60. Alan L Yuille; Fiscal Year: 2014
    ..The PIs have good track record in involving undergraduates, including women and minorities, in their NSF-sponsored research, and will continue to endeavor in the training of the next generation of computational ..
  61. Albany Medical College (AMC) Research Laboratory Facility Expansion and Improveme
    VINCENT PAUL VERDILE; Fiscal Year: 2010
    ..Research space and infrastructure (80,703 NSF) is highly compartmentalized, nearly 100% committed, and only 20% of it has been renovated within the past 10 years...
  62. Advanced Research Cooperation in Environmental Health Research
    Kathleen S Rein; Fiscal Year: 2011
    ..Our partner (RIU) institution is the University of Miami which hosts an NIEHS MFBS Center and an NIEHS/ NSF OHH Center. A two fold approach which includes faculty development and infrastructure development is being used...
  63. Frontiers in Developmental Biology: Concepts, Techniques and Model Organisms
    Eric Wieschaus; Fiscal Year: 2009
    ..The first short course was held in spring of 2005 in Brazil, and it was supported by grants from NSF's Pan American Advanced Studies Institute (PASI) Program and NICHD's Conference Grants...
  64. MEMBRANE FUSION ATPASES AND THE GOLGI APPARATUS
    Ayano Satoh; Fiscal Year: 2007
    ..The last granting period focused on the reassembly of Golgi cisternae that is catalyzed by two ATPases, NSF and p97. NSF was shown to have an activity additional to its well-characterized role in unraveling SNARE complexes...
  65. Addition and Expansion of Laboratory Animal Research Fa*
    HARRY ROZMIAREK; Fiscal Year: 2009
    ..This expansion will provide: -2,032 nsf of quarantine space for the health evaluation and rederivation of incoming mice...
  66. A VISUAL CUE MODEL TO INVESTIGATE COCAINE REWARD
    Chana Akins; Fiscal Year: 2004
    ..faculty position for 5 years, during which time she has had 10 publications, and has been awarded two small NSF Minority Planning grants and an NIH Minority Investigator Supplement...
  67. Evaluation of the Impact of a Sustained Scientist-in-the-Classroom Program
    Virginia L Shepherd; Fiscal Year: 2010
    ..being implemented by several other GK12 sites throughout the country as they begin to focus on sustainable, post- NSF funding models...
  68. 800 MHZ NMR SPECTROMETER
    David Weber; Fiscal Year: 2001
    NIH/NSF funded principal investigators at The University of Maryland, Baltimore (UMB) have scientific needs for an 800 MHz nuclear magnetic resonance (NMR) spectrometer because of an increasing number of sophisticated NMR-based research ..