NRXN1

Summary

Gene Symbol: NRXN1
Description: neurexin 1
Alias: Hs.22998, PTHSL2, SCZD17, neurexin I, neurexin-1-beta
Species: human

Top Publications

  1. ncbi Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin
    Y A Ushkaryov
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235
    Science 257:50-6. 1992
  2. doi Copy number variation in schizophrenia in the Japanese population
    Masashi Ikeda
    Medical Research Council MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
    Biol Psychiatry 67:283-6. 2010
  3. pmc Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders
    Michael S L Ching
    Division of Developmental Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Am J Med Genet B Neuropsychiatr Genet 153:937-47. 2010
  4. pmc New copy number variations in schizophrenia
    Chiara Magri
    Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, Brescia University School of Medicine, Brescia, Italy
    PLoS ONE 5:e13422. 2010
  5. pmc Disruption of neurexin 1 associated with autism spectrum disorder
    Hyung Goo Kim
    Molecular Neurogenetics Unit, Center for Human Genetic Research and Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Hum Genet 82:199-207. 2008
  6. pmc A genome-wide investigation of SNPs and CNVs in schizophrenia
    Anna C Need
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA
    PLoS Genet 5:e1000373. 2009
  7. pmc Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes
    Maja Bucan
    Autism Genetic Resource Exchange, Autism Speaks, Los Angeles, California, United States of America
    PLoS Genet 5:e1000536. 2009
  8. doi Intragenic rearrangements in NRXN1 in three families with autism spectrum disorder, developmental delay, and speech delay
    Barbara Wisniowiecka-Kowalnik
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Med Genet B Neuropsychiatr Genet 153:983-93. 2010
  9. pmc Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
    Mark R Etherton
    Department of Molecular and Cellular Physiology, Stanford University, 1050 Arastradero Road, CA 94304, USA
    Proc Natl Acad Sci U S A 106:17998-8003. 2009
  10. pmc Neurexin-1 and frontal lobe white matter: an overlapping intermediate phenotype for schizophrenia and autism spectrum disorders
    Aristotle N Voineskos
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    PLoS ONE 6:e20982. 2011

Research Grants

  1. RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism
    Barbara J Wold; Fiscal Year: 2010
  2. TrkB Agonist(s), a Potential Therapy for Autism Spectrum Disorders
    Yi Eve Sun; Fiscal Year: 2010
  3. Neural Mechanisms of Chemotherapy-Induced Cognitive Disorder
    Andrew Saykin; Fiscal Year: 2007
  4. Multicenter Genetics Studies of Schizophrenia
    Douglas Levinson; Fiscal Year: 2008
  5. GENETIC LINKAGE OF SCHIZOPHRENIA AND RELATED STUDIES
    Douglas Levinson; Fiscal Year: 2005
  6. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2007
  7. Genomic Imbalances in Autism
    Susan Christian; Fiscal Year: 2008
  8. Genetics of Early-Onset Depression
    Douglas Levinson; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications103 found, 100 shown here

  1. ncbi Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin
    Y A Ushkaryov
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235
    Science 257:50-6. 1992
    ..An antibody to neurexin I showed highly concentrated immunoreactivity at the synapse...
  2. doi Copy number variation in schizophrenia in the Japanese population
    Masashi Ikeda
    Medical Research Council MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
    Biol Psychiatry 67:283-6. 2010
    Copy number variants (CNVs) have been shown to increase the risk to develop schizophrenia. The best supported findings are at 1q21.1, 15q11.2, 15q13.3, and 22q11.2 and deletions at the gene neurexin 1 (NRXN1).
  3. pmc Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders
    Michael S L Ching
    Division of Developmental Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Am J Med Genet B Neuropsychiatr Genet 153:937-47. 2010
    Research has implicated mutations in the gene for neurexin-1 (NRXN1) in a variety of conditions including autism, schizophrenia, and nicotine dependence...
  4. pmc New copy number variations in schizophrenia
    Chiara Magri
    Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnology, Brescia University School of Medicine, Brescia, Italy
    PLoS ONE 5:e13422. 2010
    ..with a CNV occurring in one of the regions most convincingly implicated as risk factors for schizophrenia: NRXN1 and the 16p13.1 regions were found to be deleted in single patients and 15q11.2 in 2 patients, whereas the 15q13...
  5. pmc Disruption of neurexin 1 associated with autism spectrum disorder
    Hyung Goo Kim
    Molecular Neurogenetics Unit, Center for Human Genetic Research and Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Hum Genet 82:199-207. 2008
    ..We have implicated the neurexin 1 (NRXN1) gene in two independent subjects who display an autism spectrum disorder (ASD) in association with a balanced ..
  6. pmc A genome-wide investigation of SNPs and CNVs in schizophrenia
    Anna C Need
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA
    PLoS Genet 5:e1000373. 2009
    ..provide further evidence for some smaller, previously reported, schizophrenia-associated CNVs, such as those in NRXN1 and APBA2...
  7. pmc Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes
    Maja Bucan
    Autism Genetic Resource Exchange, Autism Speaks, Los Angeles, California, United States of America
    PLoS Genet 5:e1000536. 2009
    ..Rare variants at known loci, including exonic deletions at NRXN1 and whole gene duplications encompassing UBE3A and several other genes in the 15q11-q13 region, were observed in ..
  8. doi Intragenic rearrangements in NRXN1 in three families with autism spectrum disorder, developmental delay, and speech delay
    Barbara Wisniowiecka-Kowalnik
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Med Genet B Neuropsychiatr Genet 153:983-93. 2010
    b>NRXN1 is highly expressed in brain and has been shown recently to be associated with ASD, schizophrenia, cognitive and behavioral abnormalities, and alcohol and nicotine dependence...
  9. pmc Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
    Mark R Etherton
    Department of Molecular and Cellular Physiology, Stanford University, 1050 Arastradero Road, CA 94304, USA
    Proc Natl Acad Sci U S A 106:17998-8003. 2009
    ..Together, these data indicate that the neurexin-1alpha deficiency induces a discrete neural phenotype whose extent correlates, at least in part, with impairments observed in human patients...
  10. pmc Neurexin-1 and frontal lobe white matter: an overlapping intermediate phenotype for schizophrenia and autism spectrum disorders
    Aristotle N Voineskos
    Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    PLoS ONE 6:e20982. 2011
    Structural variation in the neurexin-1 (NRXN1) gene increases risk for both autism spectrum disorders (ASD) and schizophrenia...
  11. pmc A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality
    Karin J H Verweij
    Genetic Epidemiology, Molecular Epidemiology, and Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Biol Psychol 85:306-17. 2010
    ....
  12. pmc Neurexin-1α contributes to insulin-containing secretory granule docking
    Merrie Mosedale
    Pediatric Diabetes Research Center, Veterans Affairs San Diego Healthcare System, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 287:6350-61. 2012
    ..Neurexin-1α is the only transmembrane component of the docking machinery identified thus far. Our findings provide new insights into the mechanisms of insulin granule docking and exocytosis...
  13. ncbi Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit
    M Missler
    Howard Hughes Medical Institute, University of Texas Southwestern Medical School, Dallas, Texas 75235, USA
    J Biol Chem 273:34716-23. 1998
    ..The results support the notion that neurexophilins represent a family of extracellular signaling molecules that interact with multiple receptors including all three alpha-neurexins...
  14. doi Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility
    C O'Dushlaine
    Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
    Mol Psychiatry 16:286-92. 2011
    ..01). At a gene level, CAM genes associated in all three samples (NRXN1 and CNTNAP2), which were previously implicated in specific language disorder, autism and schizophrenia...
  15. ncbi Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing
    Katsuhiko Tabuchi
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Genomics 79:849-59. 2002
    ..Consistent with their proposed role in synapse specification, neurexins thus have evolved from relatively simple genes in invertebrates to diversified genes in vertebrates with multiple promoters and extensive alternative splicing...
  16. pmc Rare NRXN1 promoter variants in patients with schizophrenia
    Abhishek K Shah
    Department of Psychiatry and Behavioral Sciences, Division of Basic Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York 10461, United States
    Neurosci Lett 475:80-4. 2010
    Copy number variants (CNVs) affecting the neurexin 1 (NRXN1) gene have been found in a subgroup of patients with schizophrenia (SZ)...
  17. doi Resequencing and follow-up of neurexin 1 (NRXN1) in schizophrenia patients
    Thomas W Mühleisen
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany Institute of Human Genetics, University of Bonn, Bonn, Germany
    Schizophr Res 127:35-40. 2011
    Large rare deletions in NRXN1 increase the risk for schizophrenia...
  18. doi Mutations affecting synaptic levels of neurexin-1β in autism and mental retardation
    Rafael J Camacho-Garcia
    Instituto de Biomedicina de Sevilla IBiS, Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla, Avda Manuel Siurot s n, Sevilla 41013, Spain
    Neurobiol Dis 47:135-43. 2012
    ..To further explore the role of the NRXN1β gene in neurodevelopmental disorders, we have sequenced the coding exons of the gene in 86 cases with autism and ..
  19. doi The putative functional rs1045881 marker of neurexin-1 in schizophrenia and clozapine response
    Tristram A P Lett
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada
    Schizophr Res 132:121-4. 2011
    Neurexin-1 (NRXN1) modulates recruitment of NMDA receptors. Furthermore, clozapine reduces hyperactivity of NMDA receptors. Thus, regulation of the NRXN1 gene may mediate the efficacy of clozapine at reducing cortical hyperactivity...
  20. pmc Novel genes identified in a high-density genome wide association study for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
    Hum Mol Genet 16:24-35. 2007
    ..Our study nominates several novel genes, such as Neurexin 1 (NRXN1), in the development of nicotine dependence while also identifying a known candidate gene, the beta3 nicotinic ..
  21. ncbi Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity
    Lee Rowen
    Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington 98103, USA
    Genomics 79:587-97. 2002
    ..genes is regulated, we have determined the complete nucleotide sequence of all three human neurexin genes: NRXN1, NRXN2, and NRXN3. Unexpectedly, two of these, NRXN1 ( approximately 1.1 Mb) and NRXN3 ( approximately 1...
  22. ncbi Neurexins: three genes and 1001 products
    M Missler
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Trends Genet 14:20-6. 1998
    ..This review describes the properties of the neurexin protein family and their potential roles in neuronal cell adhesion and intercellular signaling...
  23. pmc Disruption of the neurexin 1 gene is associated with schizophrenia
    Dan Rujescu
    Division of Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Hum Mol Genet 18:988-96. 2009
    Deletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have also been reported in two families with schizophrenia...
  24. doi Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: a preliminary study
    Gabriela Novak
    Translational Addiction Research Laboratory, Centre for Addiction and Mental Health and the University of Toronto, Toronto, Ontario, Canada
    World J Biol Psychiatry 10:929-35. 2009
    Whole genome scan studies have recently identified the NRXN1 and NRXN3 genes as potential contributing factors in the risk for nicotine addiction...
  25. ncbi Structures, alternative splicing, and neurexin binding of multiple neuroligins
    K Ichtchenko
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Biol Chem 271:2676-82. 1996
    ..Thus, neuroligins constitute a multigene family of brain-specific proteins with distinct isoforms that may have overlapping functions in mediating recognition processes between neurons...
  26. ncbi The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity
    M Koroll
    Max Delbruck Centrum fur Molekulare Medizin, Robert Rossle Strasse 10, Berlin D 13092, Germany
    J Biol Chem 276:10646-54. 2001
    ..Despite their high sequence similarity to syntenin-1, syntenin-2alpha, which interacts with neurexin I, and syntenin-2beta do not bind to neurofascin or several other transmembrane proteins that are binding partners ..
  27. ncbi Mints as adaptors. Direct binding to neurexins and recruitment of munc18
    T Biederer
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 275:39803-6. 2000
    ..Our data support a model whereby one of the functions of Mints is to localize the vesicle fusion protein Munc18 to those sites at the plasma membrane that are defined by neurexins, presumably in the vicinity of points of exocytosis...
  28. pmc Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers
    Justin Nussbaum
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA
    Hum Mol Genet 17:1569-77. 2008
    The neurexin-1 gene (NRXN1) has been shown to play a fundamental role in synaptogenesis and synaptic maintenance, as well as Ca(2+) channel and NMDA receptor recruitment...
  29. pmc Recurrent CNVs disrupt three candidate genes in schizophrenia patients
    Terry Vrijenhoek
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Am J Hum Genet 83:504-10. 2008
    ..Among the genes disrupted by the remaining rare CNVs are MYT1L, CTNND2, NRXN1, and ASTN2, genes that play an important role in neuronal functioning but--except for NRXN1--have not been ..
  30. ncbi A patient with vertebral, cognitive and behavioural abnormalities and a de novo deletion of NRXN1alpha
    F R Zahir
    J Med Genet 45:239-43. 2008
    ..3. The patient's deletion is approximately 320 kb in size and includes only the part of the NRXN1 gene that codes for the neurexin1alpha promoter and initial coding exons...
  31. ncbi Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia
    George Kirov
    Department of Psychological Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 17:458-65. 2008
    ..The first one is a deletion at 2p16.3 that was present in an affected sibling and disrupts NRXN1. The second one is a de novo duplication at 15q13.1 spanning APBA2...
  32. ncbi High frequency of neurexin 1beta signal peptide structural variants in patients with autism
    Jinong Feng
    Department of Molecular Genetics, City of Hope National Medical Center, Duarte, CA 91010 3000, USA
    Neurosci Lett 409:10-3. 2006
    ..In addition, no structural variant was found in the neurexin 2beta gene and the neurexin 3beta gene. In the context of all available data, we conclude that mutations of the neurexin 1beta gene may contribute to autism susceptibility...
  33. doi Neurexin 1alpha structural variants associated with autism
    Jin Yan
    Department of Molecular Genetics, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010 3000, USA
    Neurosci Lett 438:368-70. 2008
    ..1/192; P=0.03, Fisher's exact test, one-sided). In the context of all available data, the ultra-rare structural variants of the neurexin 1alpha gene are consistent with mutations predisposing to autism...
  34. ncbi Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins
    M Fukuda
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama, 351 0198, Japan
    Biochem Biophys Res Commun 281:1226-33. 2001
    ..In addition, Slp family proteins are differentially distributed in different mouse tissues and at different developmental stages...
  35. ncbi Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta
    Davide Comoletti
    Department of Pharmacology, University of California, La Jolla, California 92093 0636, USA
    J Biol Chem 278:50497-505. 2003
    ..We show here that glycosylation processing of neuroligin, in addition to mRNA splicing and gene selection, contributes to the specificity of the neurexin-beta/neuroligin-1 association...
  36. ncbi CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins
    Y Hata
    Department of Molecular Genetics, The University of Texa Southwestern Medical Center at Dallas, 75235, USA
    J Neurosci 16:2488-94. 1996
    ..The cytoplasmic domains of all three neurexins bind CASK in a salt-labile interaction. In neurexin I, this interaction is dependent on the C-terminal three residues...
  37. ncbi Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules
    T Nguyen
    Department of Molecular Genetics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 272:26032-9. 1997
    ....
  38. pmc Latrophilin is required for toxicity of black widow spider venom in Caenorhabditis elegans
    Christopher J Mee
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Biochem J 378:185-91. 2004
    ..RNAi (RNA interference) of this gene rendered C. elegans resistant to BWSV, whereas RNAi for CYP37A1 or a neurexin I homologue, and a deletion mutant of the related B0286.2 gene, had no effect on BWSV toxicity...
  39. pmc Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
    Joseph T Glessner
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nature 459:569-73. 2009
    ..Besides previously reported ASD candidate genes, such as NRXN1 (ref...
  40. pmc Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis
    M Grifman
    Department of Biological Chemistry, Institute of Life Sciences, Hebrew University of Jerusalem, 91904, Jerusalem, Israel
    Proc Natl Acad Sci U S A 95:13935-40. 1998
    ..Moreover, overexpression of the homologous neurexin I ligand, neuroligin-1, restored both neurite extension and expression of neurexin Ialpha...
  41. pmc Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms
    Y A Ushkaryov
    Howard Hughes Medical Institute, University of Texas Southwestern Medical School, Dallas 75235
    Proc Natl Acad Sci U S A 90:6410-4. 1993
    ..Alternative splicing was previously observed at the same positions in either neurexin I alpha or neurexin II alpha or both, suggesting that the three neurexins are subject to extensive alternative ..
  42. pmc Structural variation of chromosomes in autism spectrum disorder
    Christian R Marshall
    The Centre for Applied Genomics, The Hospital for Sick Children, Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1L7, Canada
    Am J Hum Genet 82:477-88. 2008
    ..Notwithstanding complexities, our results further implicate the SHANK3-NLGN4-NRXN1 postsynaptic density genes and also identify novel loci at DPP6-DPP10-PCDH9 (synapse complex), ANKRD11, DPYD, ..
  43. doi A synaptic trek to autism
    Thomas Bourgeron
    Human Genetics and Cognitive Functions, Institut Pasteur, 25 rue du Docteur Roux, 75015 Paris, France
    Curr Opin Neurobiol 19:231-4. 2009
    ..Mutations in NLGN3/4, SHANK3, or NRXN1 alter synaptic function and lead to mental retardation, typical autism, or Asperger syndrome...
  44. ncbi Genetics of autism spectrum disorders
    Ravinesh A Kumar
    Department of Human Genetics, University of Chicago, 920 East 58th Street, MC0077, Chicago, IL 60637, USA
    Curr Neurol Neurosci Rep 9:188-97. 2009
    ..Association studies and mutation analysis of candidate genes have implicated the synaptic genes NRXN1, NLGN3, NLGN4, SHANK3, and CNTNAP2 in ASDs...
  45. pmc TCF4, schizophrenia, and Pitt-Hopkins Syndrome
    Derek J Blake
    Department of Psychological Medicine and Neurology, Medical Research Council Center for Neuropsychiatric Genetics and Genomics, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK
    Schizophr Bull 36:443-7. 2010
    ..Recessive forms of Pitt-Hopkins syndrome are caused by mutations in NRXN1 and CNTNAP2...
  46. pmc Differential expression of presynaptic genes in a rat model of postnatal hypoxia: relevance to schizophrenia
    J U Sommer
    Department of Psychopharmacology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 260:S81-9. 2010
    ..Because of their primary presynaptic occurrence, five differentially expressed genes (CPX1, NPY, NRXN1, SNAP-25, and STX1A) have been selected for comparisons with clozapine-treated animals by qRT-PCR...
  47. ncbi A Drosophila homolog of cadherin associated with armadillo and essential for embryonic cell-cell adhesion
    H Oda
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Dev Biol 165:716-26. 1994
    ..vertebrate counterparts by a large insertion with local sequence similarity to Fat, laminin A chain, Slit, and neurexin I at the proximal region of the extracellular domain...
  48. ncbi Neurexins are differentially expressed in the embryonic nervous system of mice
    A W Puschel
    Abteilung Neurochemie, Max Planck Institut für Hirnforschung, Frankfurt Main, Germany
    J Neurosci 15:2849-56. 1995
    ..Neurexin III mRNA showed a more restricted regional expression than neurexin I and II transcripts...
  49. doi Axon growth and guidance genes identify nascent, immature, and mature olfactory sensory neurons
    Jeremy C McIntyre
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Neurosci Res 88:3243-56. 2010
    ..Cell adhesion molecules were expressed either by both immature and mature OSNs (Dscam, Ncam1, Ncam2, Nrxn1) or solely by immature OSNs (Chl1, Nfasc1, Dscaml1)...
  50. doi Schizophrenia genetics: advancing on two fronts
    Michael J Owen
    MRC Centre for Neuropsychiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Curr Opin Genet Dev 19:266-70. 2009
    ..There is evidence both for an increased burden of CNVs in schizophrenia and that risk is conferred by specific large deletions at 1q21.1 and at 15q13.2 and by deletions of NRXN1 which encodes the synaptic scaffolding protein neurexin 1.
  51. pmc Exonal elements and factors involved in the depolarization-induced alternative splicing of neurexin 2
    G Rozic
    Department of Neurobiology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Mol Neurosci 50:221-33. 2013
    The neurexin genes (NRXN1, NRXN2, and NRXN3) encode polymorphic presynaptic proteins that are implicated in synaptic plasticity and memory processing...
  52. pmc The tissue-specific RNA binding protein T-STAR controls regional splicing patterns of neurexin pre-mRNAs in the brain
    Ingrid Ehrmann
    Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS Genet 9:e1003474. 2013
    ..In the absence of endogenous T-STAR protein, Nrxn1-3 AS4 splicing repression dramatically decreased, despite physiological co-expression of Sam68...
  53. pmc Increased genome instability in human DNA segments with self-chains: homology-induced structural variations via replicative mechanisms
    Weichen Zhou
    State Key Laboratory of Genetic Engineering and Ministry of Education, Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China
    Hum Mol Genet 22:2642-51. 2013
    ..of short low-copy repeats (LCRs) in the human genome, can induce autism-associated SV mutations of the MECP2 and NRXN1 genes...
  54. doi Rare variants analysis of neurexin-1β in autism reveals a novel start codon mutation affecting protein levels at synapses
    Rafael J Camacho-Garcia
    aSeville Biomedical Research Institute IBiS, Virgen del Rocio University Hospital, CSIC bDepartment of Medical Physiology and Biophysics, University of Seville, Seville cChild and Adolescent Mental Health Unit, Mutua de Terrassa University Hospital, Terrassa dDepartment of Genetics, Faculty of Biology, University of Barcelona eBiomedical Network Research Centre on Rare Diseases CIBERER fInstitute of Biomedicine IBUB, University of Barcelona, Barcelona, Spain
    Psychiatr Genet 23:262-6. 2013
    Neurexins are synaptic plasma membrane proteins encoded by three genes (NRXN1, -2, -3) with alternative promoters. Mutations in neurexin genes have been identified in different neurodevelopmental disorders, including autism...
  55. pmc Phenotypic spectrum and genotype-phenotype correlations of NRXN1 exon deletions
    Christian P Schaaf
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Hum Genet 20:1240-7. 2012
    Copy number variants (CNVs) and intragenic rearrangements of the NRXN1 (neurexin 1) gene are associated with a wide spectrum of developmental and neuropsychiatric disorders, including intellectual disability, speech delay, autism ..
  56. pmc Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disorders
    Luigi Boccuto
    Greenwood Genetic Center, Greenwood, SC, USA
    Eur J Hum Genet 21:310-6. 2013
    ..associated with ASDs are involved in the neuroligin-neurexin interaction at the glutamate synapse: NLGN3, NLGN4, NRXN1, CNTNAP2, and SHANK3...
  57. pmc Analysis of copy number variation in Alzheimer's disease: the NIALOAD/ NCRAD Family Study
    Shanker Swaminathan
    Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA
    Curr Alzheimer Res 9:801-14. 2012
    ..analyses confirmed previous findings in the ADNI study (ATXN1, HLA-DPB1, RELN, DOPEY2, GSTT1, CHRFAM7A, ERBB4, NRXN1) and identified a new gene (IMMP2L) that may play a role in AD susceptibility...
  58. doi Expression of neurexin and neuroligin in the enteric nervous system and their down-regulated expression levels in Hirschsprung disease
    Qiangye Zhang
    Department of Pediatric Surgery, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan 250012, Shandong, China
    Mol Biol Rep 40:2969-75. 2013
    ..Double labeling of neurexin I and Hu (a neuron marker), neuroligin 1 and Hu, neurexin I and synaptophysin (a presynaptic marker), and ..
  59. doi Exon-disrupting deletions of NRXN1 in idiopathic generalized epilepsy
    Rikke S Møller
    Danish Epilepsy Center, Dianalund, Denmark
    Epilepsia 54:256-64. 2013
    ..Recently, deletions and point mutations of the neurexin 1 (NRXN1) gene have been associated with a broad spectrum of neuropsychiatric disorders...
  60. doi Investigation of NRXN1 deletions: clinical and molecular characterization
    Mindy Preston Dabell
    Signature Genomic Laboratories, PerkinElmer, Inc, Spokane, WA, USA
    Am J Med Genet A 161:717-31. 2013
    Deletions at 2p16.3 involving exons of NRXN1 are associated with susceptibility for autism and schizophrenia, and similar deletions have been identified in individuals with developmental delay and dysmorphic features...
  61. doi Functional analysis of TCF4 missense mutations that cause Pitt-Hopkins syndrome
    Marc Forrest
    Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK
    Hum Mutat 33:1676-86. 2012
    ..Autosomal dominant PTHS is caused by mutations in the transcription factor 4 (TCF4) gene, whereas NRXN1 and CNTNAP2 mutations are associated with autosomal recessive PTHS...
  62. pmc Allele-biased expression in differentiating human neurons: implications for neuropsychiatric disorders
    Mingyan Lin
    Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 7:e44017. 2012
    ..These included a number of putative SZ and ASD candidates, such as A2BP1 (RBFOX1), ERBB4, NLGN4X, NRG1, NRG3, NRXN1, and NLGN1...
  63. doi Mutation analysis of the NRXN1 gene in a Chinese autism cohort
    Yalan Liu
    School of Biological Science and Technology, Central South University, Changsha, Hunan, China
    J Psychiatr Res 46:630-4. 2012
    ..The neurexin-1(NRXN1) gene mapped on chromosome 2p16...
  64. ncbi Solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr
    Heyue Zhou
    Hefei National Laboratory for Physical Sciences at Microscale, School of Life Science, University of Science and Technology of China, Hefei, Anhui 230026, People s Republic of China
    J Biol Chem 280:13841-7. 2005
    ..Unlike the canonical class II PDZ domain, Ala74 at alphaB5 rather than the residue at alphaB1 makes direct hydrophobic contact with the side chain of Tyr at the -2 position of the ligand...
  65. pmc High frequency of known copy number abnormalities and maternal duplication 15q11-q13 in patients with combined schizophrenia and epilepsy
    Larissa R Stewart
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030 USA
    BMC Med Genet 12:154. 2011
    ..Chromosomal deletions of 1q21.1, 3q29, 15q13.3, 22q11.2, and NRXN1 and duplications of 15q11-q13 (maternal), 16p11, and 16p13.3 have the strongest association with schizophrenia...
  66. pmc CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila
    Christiane Zweier
    Institute of Human Genetics, Friedrich Alexander University Erlangen Nuremberg, 91054 Erlangen, Germany
    Am J Hum Genet 85:655-66. 2009
    Heterozygous copy-number variants and SNPs of CNTNAP2 and NRXN1, two distantly related members of the neurexin superfamily, have been repeatedly associated with a wide spectrum of neuropsychiatric disorders, such as developmental ..
  67. pmc Genetic regulation of Nrxn1 [corrected] expression: an integrative cross-species analysis of schizophrenia candidate genes
    K Mozhui
    Department of Anatomy and Neurobiology, Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Transl Psychiatry 1:e25. 2011
    Neurexin 1 (NRXN1) is a large presynaptic transmembrane protein that has complex and variable patterns of expression in the brain. Sequence variants in NRXN1 are associated with differences in cognition, and with schizophrenia and autism...
  68. doi Development of patient-specific neurons in schizophrenia using induced pluripotent stem cells
    Erika Pedrosa
    Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, New York 10416, USA
    J Neurogenet 25:88-103. 2011
    ..proteins and synaptic proteins relevant to SZ pathogenesis, including ZNF804A, RELN, CNTNAP2, CTNNA2, SMARCA2, and NRXN1. Although a small number of lines were developed in this preliminary study, the SZ line containing 22q11...
  69. ncbi Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action
    M Geppert
    Max Planck Institut fur experimentelle Medizin, Gottingen, Germany
    J Biol Chem 273:1705-10. 1998
    ..description of two distinct cell surface proteins that bind alpha-latrotoxin with nanomolar affinities; Neurexin I alpha binds alpha-latrotoxin in a Ca(2+)-dependent manner, and CIRL/latrophilin binds in a Ca(2+)-independent ..
  70. doi Compound heterozygous deletion of NRXN1 causing severe developmental delay with early onset epilepsy in two sisters
    Victoria Harrison
    Department of Clinical Genetics, Churchill Hospital, Oxford, UK
    Am J Med Genet A 155:2826-31. 2011
    Neurexin 1 (NRXN1) is a cell adhesion protein, the normal function of which is critical for effective neurotransmission. It forms a trans-synaptic complex in the central nervous system with neuroligin...
  71. pmc Rare deletions at the neurexin 3 locus in autism spectrum disorder
    Andrea K Vaags
    Program in Genetics and Genome Biology, The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Am J Hum Genet 90:133-41. 2012
    The three members of the human neurexin gene family, neurexin 1 (NRXN1), neurexin 2 (NRXN2), and neurexin 3 (NRXN3), encode neuronal adhesion proteins that have important roles in synapse development and function...
  72. doi Detection and characterization of copy number variation in autism spectrum disorder
    Christian R Marshall
    The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada
    Methods Mol Biol 838:115-35. 2012
    ..2, SHANK2, NRXN1, and PTCHD1...
  73. ncbi alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor
    V G Krasnoperov
    Department of Environmental Medicine, New York University Medical Center, New York 10016, USA
    Neuron 18:925-37. 1997
    ..Its action requires extracellular binding to high affinity presynaptic receptors. Neurexin I alpha was previously described as a high affinity alpha-latrotoxin receptor that binds the toxin only in the ..
  74. pmc Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells
    John Kinzfogl
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Blood 118:565-75. 2011
    b>Neurexin I α (NRXN1α) and Dystroglycan (DAG1) are membrane receptors which serve as mutual ligands in the neuronal system. Neurexophilins (NXPHs) bind NRXN1α...
  75. ncbi Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons
    B Ullrich
    Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical School, Dallas 75235
    Neuron 14:497-507. 1995
    ..Characterization of many independent bovine neurexin I alpha cDNAs suggests that different splice sites are used independently...
  76. ncbi Structure and evolution of neurexophilin
    A G Petrenko
    Howard Hughes Medical Institute, University of Texas Southwestern Medical School, Dallas, Texas 75235, USA
    J Neurosci 16:4360-9. 1996
    ..Together our data suggest that neurexophilin constitutes a secreted glycoprotein that is synthesized in a subclass of neurons and may be a ligand for neurexins...
  77. ncbi Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin
    M S Perin
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Biochemistry 35:13808-16. 1996
    ..These data suggest that multiple synaptotagmins may interact with neurexins to mediate docking or regulation of neurotransmitter release and that synaptotagmins may be calcium-regulated via interaction with calmodulin...
  78. pmc A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB
    Anna C Need
    Center for Human Genome Variation, Institute for Genome Sciences and Policy, Duke University, 450 Research Drive, Box 91009, Durham, NC 27708, USA
    Hum Mol Genet 18:4650-61. 2009
    ..Only NRXN1 showed evidence of significant association with cognition...
  79. pmc PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor
    B Hock
    Chemotherapeutisches Forschungsinstitut, Georg Speyer Haus, Paul Ehrlich Strasse 42 44, 60596 Frankfurt, Germany
    Proc Natl Acad Sci U S A 95:9779-84. 1998
    ....
  80. pmc Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment: An ADNI Study
    Shanker Swaminathan
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Alzheimers Dis 2011:729478. 2011
    ..gene-based analyses revealed CNVs overlapping the candidate gene CHRFAM7A, as well as CSMD1, SLC35F2, HNRNPCL1, NRXN1, and ERBB4 regions, only in cases...
  81. pmc A genome-wide scanning and fine mapping study of COGA data
    Hsin Chou Yang
    Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    BMC Genet 6:S30. 2005
    ..The final model identified important AD-related haplotypes within a candidate region of NRXN1 at 2p21 and a few others in the inter-gene regions...
  82. pmc Neuronal cell adhesion genes: Key players in risk for schizophrenia, bipolar disorder and other neurodevelopmental brain disorders?
    Aiden P Corvin
    Department of Psychiatry Neuropsychiatric Genetics Laboratory, Trinity College, Dublin, Ireland
    Cell Adh Migr 4:511-4. 2010
    ..Disruption of a number of these genes (including NRXN1, CNTNAP2 and CASK) are known to cause diverse neurodevelopmental brain disorder phenotypes including schizophenia, ..
  83. pmc Structural insights into the exquisite selectivity of neurexin/neuroligin synaptic interactions
    Philippe Leone
    Architecture et Fonction des Macromolecules Biologiques, CNRS Université d Aix Marseille, Campus Luminy, Marseille, France
    EMBO J 29:2461-71. 2010
    ..Although neuroligin-1 and neuroligin-2 have pre-determined conformations that respectively promote and prevent Nrx1beta association, unique conformational reshaping of the NL4 surface is required to permit Nrx1beta association...
  84. ncbi Ca2+ -dependent splicing of neurexin IIalpha
    G Rozic-Kotliroff
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Biochem Biophys Res Commun 352:226-30. 2007
    Neurexins are synaptic adhesion proteins encoded by 3 genes (NRXN1, NRXN2, and NRXN3) each transcribed from 2 promoters to yield longer (alpha) and shorter (beta) forms...
  85. ncbi The possible interplay of synaptic and clock genes in autism spectrum disorders
    T Bourgeron
    Department of Neuroscience, Institut Pasteur, Paris, France
    Cold Spring Harb Symp Quant Biol 72:645-54. 2007
    ..associated with susceptibility to ASD, which includes the synaptic cell adhesion molecules NLGN3, NLGN4, and NRXN1 and a postsynaptic scaffolding protein SHANK3...
  86. pmc Bridging the synaptic gap: neuroligins and neurexin I in Apis mellifera
    Sunita Biswas
    University of Queensland, Queensland Brain Institute, Brisbane, Queensland, Australia
    PLoS ONE 3:e3542. 2008
    ..Whereas vertebrates have three neurexins the bee has just one gene named neurexin I (400 kb, 28 exons)...
  87. pmc Hotspots of large rare deletions in the human genome
    W Edward C Bradley
    Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    PLoS ONE 5:e9401. 2010
    ..We have examined the genomic distribution of large rare autosomal deletions in a sample of 440 parent-parent-child trios from the Quebec founder population (QFP) which was recruited for a study of Attention Deficit Hyperactivity Disorder...
  88. doi Prenatal exposure to valproic acid leads to reduced expression of synaptic adhesion molecule neuroligin 3 in mice
    E Kolozsi
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Neuroscience 163:1201-10. 2009
    ..with densitometry to examine expression of three NLGN genes (NLGN1, NLGN2, and NLGN3) and three NRXN genes (NRXN1, NRXN2, and NRXN3)...
  89. pmc Sensory regulation of neuroligins and neurexin I in the honeybee brain
    Sunita Biswas
    Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia
    PLoS ONE 5:e9133. 2010
    ..Therefore, we investigated whether neuroligins and neurexin are differentially regulated by sensory input using a behavioural model system with an advanced capacity for sensory processing, learning and memory, the honeybee...
  90. pmc Describing the hexapeptide identity platform between the influenza A H5N1 and Homo sapiens proteomes
    Darja Kanduc
    Department of Biochemistry and Molecular Biology, University of Bari, Italy
    Biologics 4:245-61. 2010
    ..many human proteins that share peptide sequences with influenza A polyprotein are antigens such as reelin, neurexin I-α, myosin-IXa, Bardet-Biedl syndrome 10 protein, Williams syndrome transcription factor, disrupted in ..
  91. doi Influence of neurexin 1 (NRXN1) polymorphisms in clozapine response
    Renan P Souza
    Neurogenetics Section, Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Hum Psychopharmacol 25:582-5. 2010
    ..We tested this association using polymorphisms in the neurexin 1 gene (NRXN1). Large NRXN1 deletions have also been associated with schizophrenia...
  92. doi Gene and miRNA expression profiles in autism spectrum disorders
    Mohammad M Ghahramani Seno
    The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada
    Brain Res 1380:85-97. 2011
    ..Some rare and highly-penetrant gene variants and copy number variation (CNV) regions including NLGN3, NLGN4, NRXN1, SHANK2, SHANK3, PTCHD1, 1q21.1, maternally-inherited duplication of 15q11-q13, 16p11...
  93. ncbi [alpha-Latrotoxin as an instrument for studying neurosecretions]
    N H Himmel'reĭkh
    Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv
    Ukr Biokhim Zh 72:26-34. 2000
    ..Calcium-dependent receptor of alpha-latrotoxin is identified as neurexin I alpha and belongs to the family of neurexins. This family is selectively expressed in nerve tissue...
  94. doi A 10.46 Mb 12p11.1-12.1 interstitial deletion coincident with a 0.19 Mb NRXN1 deletion detected by array CGH in a girl with scoliosis and autism
    Yasemin Soysal
    Department of Medical Genetics, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey
    Am J Med Genet A 155:1745-52. 2011
    ..Short arm of chromosome 12 interstitial deletions are rarely reported whereas point mutations and deletions of NRXN1, which is located on chromosome 2p16.3, are associated with ASDs...
  95. pmc Presenilin/γ-secretase regulates neurexin processing at synapses
    Carlos A Saura
    Institut de Neurociencies, Departament de Bioquimica i Biologia Molecular, Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    PLoS ONE 6:e19430. 2011
    ..These results suggest that PS regulate the synaptic function and processing of neurexins at glutamatergic synapses, and that impaired neurexin processing by PS may play a role in FAD...
  96. pmc A case-control association study of NRXN1 polymorphisms with schizophrenia in Chinese Han population
    Weihua Yue
    Institute of Mental Health, Peking University Beijing, 100191, PR China
    Behav Brain Funct 7:7. 2011
    Recent research has implicated that mutations in the neurexin-1 (NRXN1) gene on chromosome 2p16.3 might play a role in schizophrenia, autism, and nicotine dependence...
  97. pmc Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia
    Julie Gauthier
    Centre of Excellence in Neuromics of Université de Montréal, Centre Hospitalier de l Universite de Montreal, Montreal, Canada
    Hum Genet 130:563-73. 2011
    ..Copy number variations and deleterious mutations in synaptic organizing proteins including NRXN1 have been associated with these neurodevelopmental disorders, but no such associations have been reported for ..
  98. pmc Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)
    M Fukuda
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochem J 354:249-57. 2001
    ..Since Syt XIII is expressed in various tissues outside the brain, Syt XIII may be involved in constitutive vesicle transport...
  99. doi The neurobiology of schizophrenia: new leads and avenues for treatment
    Nicholas J Bray
    Department of Neuroscience, Institute of Psychiatry, King s College London, UK
    Curr Opin Neurobiol 20:810-5. 2010
    ..ZNF804A, TCF4 and NRGN, which contain common variants that weakly increase schizophrenia susceptibility, and NRXN1, in which rare copy number variants have a greater impact on schizophrenia risk...
  100. ncbi Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism
    Alexander A Chubykin
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390 9111, USA
    J Biol Chem 280:22365-74. 2005
    ....

Research Grants8

  1. RNA-Seq studies of Gene Expression in Cells and Networks in FI and ACC in Autism
    Barbara J Wold; Fiscal Year: 2010
    ..an autism-B group, which is characterized by increased expression of genes in the presynaptic terminal including NRXN1 (neurexin 1), which provides Velcro-like binding to neuroligins in the post-synaptic membrane...
  2. TrkB Agonist(s), a Potential Therapy for Autism Spectrum Disorders
    Yi Eve Sun; Fiscal Year: 2010
    ..Mutations of genes such as neurexin 1 (NRXN1), neuroligin3 and 4 (NLGN3/4), SHANK3, PTEN have been associated with autism...
  3. Neural Mechanisms of Chemotherapy-Induced Cognitive Disorder
    Andrew Saykin; Fiscal Year: 2007
    ..abstract_text> ..
  4. Multicenter Genetics Studies of Schizophrenia
    Douglas Levinson; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  5. GENETIC LINKAGE OF SCHIZOPHRENIA AND RELATED STUDIES
    Douglas Levinson; Fiscal Year: 2005
    ..abstract_text> ..
  6. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2007
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  7. Genomic Imbalances in Autism
    Susan Christian; Fiscal Year: 2008
    ..These data will be valuable in both identifying polymorphic variants in normal human control samples and also identifying chromosomal dosage imbalances that are associated with autism. ..
  8. Genetics of Early-Onset Depression
    Douglas Levinson; Fiscal Year: 2008
    ..abstract_text> ..