NRG1

Summary

Gene Symbol: NRG1
Description: neuregulin 1
Alias: ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF, pro-neuregulin-1, membrane-bound isoform, acetylcholine receptor-inducing activity, glial growth factor 2, heregulin, alpha (45kD, ERBB2 p185-activator), neu differentiation factor, pro-NRG1, sensory and motor neuron derived factor
Species: human

Top Publications

  1. pmc Neuronal Neuregulin 1 type III directs Schwann cell migration
    Julie R Perlin
    Department of Developmental Biology, 279 Campus Dr, Beckman Center B300, Stanford University, Stanford, CA 94305, USA
    Development 138:4639-48. 2011
  2. pmc Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination
    XiaoYang Luo
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 286:23967-74. 2011
  3. ncbi Activation of the neuregulin-1/ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumors
    Mark S Stonecypher
    Department of Cell Biology, The University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Oncogene 24:5589-605. 2005
  4. pmc Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 66:614-20. 2009
  5. pmc Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury
    James H Finigan
    Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 286:10660-70. 2011
  6. pmc Differential neuregulin 1 cleavage in the prefrontal cortex and hippocampus in schizophrenia and bipolar disorder: preliminary findings
    Ketan Marballi
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e36431. 2012
  7. doi Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia
    Hong Xing Zhang
    Institute of Mental Health of the Second Xiangya Hospital, Central South University, Changsha 410011, China
    Neurosci Lett 438:1-5. 2008
  8. pmc Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure
    Bonnie Ky
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 120:310-7. 2009
  9. pmc Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination
    Viktorija Velanac
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Glia 60:203-17. 2012
  10. ncbi Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychoses
    Rodney C P Go
    University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Med Genet B Neuropsychiatr Genet 139:28-32. 2005

Research Grants

  1. Molecular Basis of Neuron-Gila Interactions in the CNS
    Gabriel Corfas; Fiscal Year: 2009
  2. Mechanisms of schizophrenia-like phenotypes in BACE 1 knockout mice
    Alena Savonenko; Fiscal Year: 2010
  3. NANCY MEIYUN CHIU BIVENS; Fiscal Year: 2014
  4. Developmental role of Neuregulin-1 in subventricular zone stem cell fate
    Heather El-Amamy; Fiscal Year: 2013
  5. David L Braff; Fiscal Year: 2015
  6. Role of neuregulin 1 signaling in cortical maturation and schizophrenia
    Yachi Chen; Fiscal Year: 2013
  7. EXPRESSION OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS
    Lorna Role; Fiscal Year: 2009
  8. Generation and Characterization of GAD67-ErbB4 Transgenic Mice
    Lin Mei; Fiscal Year: 2010
  9. Larry J Siever; Fiscal Year: 2015
  10. Neuregulin 1 signaling and schizophrenia: effect of transmembrane domain variants
    David A Talmage; Fiscal Year: 2012

Detail Information

Publications269 found, 100 shown here

  1. pmc Neuronal Neuregulin 1 type III directs Schwann cell migration
    Julie R Perlin
    Department of Developmental Biology, 279 Campus Dr, Beckman Center B300, Stanford University, Stanford, CA 94305, USA
    Development 138:4639-48. 2011
    ..We demonstrate that zebrafish Neuregulin 1 (Nrg1) type III, which signals through ErbB receptors, controls Schwann cell migration in addition to its previously ..
  2. pmc Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination
    XiaoYang Luo
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 286:23967-74. 2011
    Neuregulin-1 (Nrg1) is encoded by a single gene and exists in naturally secreted and transmembrane isoforms. Nrg1 exerts its signaling activity through interaction with its cognate ErbB receptors...
  3. ncbi Activation of the neuregulin-1/ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumors
    Mark S Stonecypher
    Department of Cell Biology, The University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Oncogene 24:5589-605. 2005
    ..These findings suggest that autocrine and/or paracrine NRG-1/erbB signaling promotes neoplastic Schwann cell proliferation and may be an important therapeutic target in neurofibromas and MPNSTs...
  4. pmc Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 66:614-20. 2009
    ..Therefore, we aimed to replicate these results and investigated the impact of the related polymorphisms on PPI in healthy human volunteers...
  5. pmc Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury
    James H Finigan
    Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 286:10660-70. 2011
    ..Finally, NRG-1 was detectable and elevated in pulmonary edema fluid from patients with ALI. These results suggest that the ADAM17-NRG-1-HER2 axis modulates the alveolar epithelial barrier and contributes to the pathophysiology of ALI...
  6. pmc Differential neuregulin 1 cleavage in the prefrontal cortex and hippocampus in schizophrenia and bipolar disorder: preliminary findings
    Ketan Marballi
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 7:e36431. 2012
    Neuregulin 1 (NRG1) is a key candidate susceptibility gene for both schizophrenia (SCZ) and bipolar disorder (BPD). The function of the NRG1 transmembrane proteins is regulated by cleavage...
  7. doi Explorative study on the expression of neuregulin-1 gene in peripheral blood of schizophrenia
    Hong Xing Zhang
    Institute of Mental Health of the Second Xiangya Hospital, Central South University, Changsha 410011, China
    Neurosci Lett 438:1-5. 2008
    ..These results demonstrated that Nrg-1 gene has association with schizophrenia. It is possible to select Nrg-1 mRNA expression of PBLs in schizophrenia patients as a potential therapeutic marker...
  8. pmc Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure
    Bonnie Ky
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Circulation 120:310-7. 2009
    ..However, circulating NRG-1 has not been studied in human heart disease. We used a novel immunoassay to test whether circulating NRG-1beta is associated with disease severity and clinical outcomes in chronic heart failure...
  9. pmc Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination
    Viktorija Velanac
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Glia 60:203-17. 2012
    Myelin sheath thickness is precisely adjusted to axon caliber, and in the peripheral nervous system, neuregulin 1 (NRG1) type III is a key regulator of this process...
  10. ncbi Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychoses
    Rodney C P Go
    University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Med Genet B Neuropsychiatr Genet 139:28-32. 2005
    ..schizophrenia, in the Icelandic population identified a risk haplotype within the 5' region of neuregulin-1 (NRG1) on 8p12...
  11. ncbi Transmembrane neuregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognition
    J Y Wang
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 273:20525-34. 1998
    ..To our knowledge, LIMK1 is the first identified protein shown to interact with the cytoplasmic tail of a receptor tyrosine kinase ligand...
  12. ncbi Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1
    Shiny V Mathew
    Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 1385, USA
    Hum Mol Genet 16:2921-32. 2007
    Studies in cell culture and in animals suggest that neuregulin 1 (NRG1), a probable schizophrenia susceptibility gene, regulates the expression of the alpha7 nicotinic acetylcholine receptors (nAChRs)...
  13. doi Neuregulin-1 and the P300 waveform--a preliminary association study using a psychosis endophenotype
    Elvira Bramon
    Institute of Psychiatry King s College London, Division of Psychological Medicine and Psychiatry box 63, De Crespigny Park, London SE5 8AF, United Kingdom
    Schizophr Res 103:178-85. 2008
    Neuregulin-1 (NRG1) has been put forward as a susceptibility gene for schizophrenia. We investigated the association between Neuregulin-1 and the P300 wave, a schizophrenia endophenotype.
  14. pmc The fibroblast-derived paracrine factor neuregulin-1 has a novel role in regulating the constitutive color and melanocyte function in human skin
    Wonseon Choi
    Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 123:3102-11. 2010
    ....
  15. doi Neuregulin-1 suppresses cardiomyocyte apoptosis by activating PI3K/Akt and inhibiting mitochondrial permeability transition pore
    Bingzhang Jie
    Beijing Anzhen Hospital, Capital Medical University, Beijing, China
    Mol Cell Biochem 370:35-43. 2012
    ..Taken together, these findings suggest that NRG-1 activates PI3K/Akt signaling and inhibits mPTP opening, and downstream apoptotic events in cardiac myocytes subjected to oxidative stress...
  16. ncbi Therapeutic effects of neuregulin-1 gene transduction in rats with myocardial infarction
    Jian Xiao
    Hypertensive Research Institute, First Affiliated Hospital, Nanchang University, Nanchang, China
    Coron Artery Dis 23:460-8. 2012
    ..In this study, we investigated whether lentivirus-mediated gene transduction improves the cardiac function in rats with myocardial infarction and the mechanisms involved...
  17. pmc Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer
    Jiyoung Park
    Touchstone Diabetes Center and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:21058-63. 2012
    ..Our findings highlight the targeted inhibition of NRG1-HER3 pathways as a potential target for the treatment breast cancer patients with associated diabetes.
  18. doi Spheroid culture of primary lung cancer cells with neuregulin 1/HER3 pathway activation
    Hiroko Endo
    Departments of Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Thorac Oncol 8:131-9. 2013
    ..We recently developed the cancer tissue-originated spheroid (CTOS) method for the primary culture of colorectal cancer cells. In the present study, we applied this system to the primary culture of non-small-cell lung cancer...
  19. pmc A common missense variant in the neuregulin 1 gene is associated with both schizophrenia and sudden cardiac death
    Adriana Huertas-Vazquez
    The Heart Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Heart Rhythm 10:994-8. 2013
    ..We hypothesized that DNA variants within genes previously associated with schizophrenia and epilepsy may contribute to an increased risk of SCD...
  20. doi Neuregulin-1 type I: a hidden power within Schwann cells for triggering peripheral nerve remyelination
    Anand Krishnan
    Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, Canada
    Sci Signal 6:jc1. 2013
    ..Specifically expressed in Schwann cells at critical time points after nerve injury, this isoform of NRG-1 emerges as a driving force for regeneration and remyelination programs...
  21. doi Neuregulin 1 role in Schwann cell regulation and potential applications to promote peripheral nerve regeneration
    Giovanna Gambarotta
    Nerve Regeneration Group, Department of Clinical and Biological Sciences, University of Torino, Torino, Italy Electronic address
    Int Rev Neurobiol 108:223-56. 2013
    Neuregulin 1 (NRG1) is a multifunctional and versatile protein: its numerous isoforms can signal in a paracrine, autocrine, or juxtacrine manner, playing a fundamental role during the development of the peripheral nervous system and ..
  22. ncbi No evidence for linkage or association of neuregulin-1 (NRG1) with disease in the Irish study of high-density schizophrenia families (ISHDSF)
    D L Thiselton
    Department of Psychiatry, Virginia Institute of Psychiatric and Behavioural Genetics, Virginia Commonwealth University, Richmond, VA, USA
    Mol Psychiatry 9:777-83; image 729. 2004
    The neuregulin-1 gene (NRG1) at chromosome 8p21-22 has been implicated as a schizophrenia susceptibility gene in Icelandic, Scottish, Irish and mixed UK populations...
  23. ncbi Case-control and family-based association studies between the neuregulin 1 (Arg38Gln) polymorphism and schizophrenia
    Chen Jee Hong
    Division of Psychiatry, Taipei Veterans General Hospital, No 2 1 Shih Pai Road, Sec 2, Taipei 11217, Taiwan, ROC
    Neurosci Lett 366:158-61. 2004
    Genetic variations in the neuregulin 1 (NRG1), a critical gene in neuronal development, have been reported to be associated with schizophrenia in several reports...
  24. pmc Role of proneuregulin 1 cleavage and human epidermal growth factor receptor activation in hypertonic aquaporin induction
    Andreas Herrlich
    Renal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 101:15799-804. 2004
    ..We propose that ligand-dependent HER activation constitutes a generalized signaling principle in the mammalian hypertonic stress response relevant to aquaporin expression...
  25. pmc The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognition
    James J Crowley
    Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599 7264, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1298-300. 2008
    The neuregulin 1 (NRG1) promoter single nucleotide polymorphism (SNP) rs6994992 has shown association with decreased activation of frontal and temporal lobe regions, increased risk of psychosis, and decreased premorbid IQ...
  26. doi Is neuregulin 1 involved in determining cerebral volumes in schizophrenia? Preliminary results showing a decrease in superior temporal gyrus volume
    Sarah Tosato
    Department of Public Health and Community Medicine, Section of Psychiatry and Clinical Psychology, University of Verona, Verona, Italy sarah tosato univr it
    Neuropsychobiology 65:119-25. 2012
    ..It has been proposed that Neuregulin 1 (NRG1) might be a promising gene involved in schizophrenia, because of its role in neurodevelopment and neuroplasticity...
  27. doi Association study of neuregulin 1 gene polymorphisms with auditory P300 in schizophrenia
    Chuanyuan Kang
    Department of Psychiatry, The First Affiliated Hospital of Kunming Medical College, Kunming, China
    Am J Med Genet B Neuropsychiatr Genet 159:422-8. 2012
    Neuregulin 1 (NRG1), a gene involved with myelin production has been shown to have a positive correlation with schizophrenia...
  28. doi Neuregulin-1/ErbB4 signaling controls the migration of oligodendrocyte precursor cells during development
    M Cristina Ortega
    Grupo de Neurobiología del Desarrollo GNDe, Hospital Nacional de Paraplejicos, Toledo, Spain
    Exp Neurol 235:610-20. 2012
    ..In the present study, we have used the optic nerve as an experimental model to examine the function of Nrg1 and its ErbB4 receptor in the migration of OPCs in the developing embryo...
  29. ncbi Expression of neuregulin 1, a member of the epidermal growth factor family, is expressed as multiple splice variants in the adult human cornea
    Donald J Brown
    Department of Ophthalmology, College of Medicine, University of California at Irvine, Irvine, California 92868, USA
    Invest Ophthalmol Vis Sci 45:3021-9. 2004
    ..To determine whether neuregulin 1 (Nrg-1) is expressed in the normal adult human cornea...
  30. ncbi Intra- and extracellular signaling by endothelial neuregulin-1
    Erika Iivanainen
    Department of Medical Biochemistry and Molecular Biology, and Medicity Research Laboratories, University of Turku, Turku, Finland
    Exp Cell Res 313:2896-909. 2007
    ..These results indicate that NRG-1 is expressed by ECs and regulates angiogenesis by mechanisms involving paracrine up-regulation of VEGF-A...
  31. doi No association between neuregulin 1 and psychotic symptoms in Alzheimer's disease patients
    Fiona Middle
    Molecular Psychiatry Group, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    J Alzheimers Dis 20:561-7. 2010
    ..Variants within the neuregulin-1 (NRG1) gene have been investigated both in early onset psychiatric disorders, such as schizophrenia and recently in AD ..
  32. ncbi Neuregulin 1 gene and variations in perceptual aberration of schizotypal personality in adolescents
    Hsiao Fan Lin
    Institute of Epidemiology, College of Public Health, National Taiwan University, 1 Jen Ai Road, Sec 1, Taipei 100, Taiwan
    Psychol Med 35:1589-98. 2005
    We test the hypothesis that the neuregulin 1 (NRG1 ) gene at chromosome 8p22-p12, which has been implicated as a susceptibility gene to schizophrenia, is associated with variations in schizotypal personality in non-clinical populations.
  33. ncbi Neuregulin-1 genotype moderates the association between job strain and early atherosclerosis in young men
    Mirka Hintsanen
    Department of Psychology, University of Helsinki, Finland
    Ann Behav Med 33:148-55. 2007
    ..Neuregulin-1 (NRG-1) has various roles in the development and function of the heart and autonomic nervous system...
  34. ncbi Schizophrenia susceptibility genes and their neurodevelopmental implications: focus on neuregulin 1
    Paul J Harrison
    University of Oxford, Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    Novartis Found Symp 288:246-55; discussion 255-9, 276-81. 2007
    ..Here, the genetic advances and their neurodevelopmental implications are summarised, with a particular focus on neuregulin 1...
  35. doi Decreased Neuregulin 1 C-terminal fragment in Brodmann's area 6 of patients with schizophrenia
    Adel Barakat
    Department of Pathology, The University of Melbourne, Parkville, VIC 3010, Australia
    Schizophr Res 124:200-7. 2010
    Neuregulin 1 (NRG1) is a susceptibility gene for schizophrenia. A decrease in NRG1-ErbB4 signalling has also been associated with the disease...
  36. doi Dysbindin-1 and NRG-1 gene expression in immortalized lymphocytes from patients with schizophrenia
    Hidenaga Yamamori
    Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Osaka, Japan
    J Hum Genet 56:478-83. 2011
    ..Our findings suggest that the gene expression profile of immortalized lymphocyte from schizophrenic patients is different from that in postmortem brain tissue at least with respect to the dysbindin-1 and NRG-1 genes...
  37. pmc Circulating neuregulin-1β levels vary according to the angiographic severity of coronary artery disease and ischemia
    Carrie Anna Geisberg
    Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Coron Artery Dis 22:577-82. 2011
    ..NRG-1β is essential for cardiovascular development and a regulator of angiogenesis. We postulated that plasma and serum levels of NRG-1β would vary in relation to CAD severity and the presence of stress-induced ischemia...
  38. doi Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy
    Ke xin Li
    Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
    Nat Neurosci 15:267-73. 2011
    ..ErbB4, a key Neuregulin 1 (NRG1) receptor, is mainly expressed in this type of interneurons, and recent studies suggest that parvalbumin ..
  39. pmc Family-based association study of Neuregulin 1 with psychotic bipolar disorder
    Fernando S Goes
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 150:693-702. 2009
    The Neuregulin 1 gene (NRG1) has been associated with schizophrenia, and, to a lesser extent, with bipolar disorder (BP)...
  40. doi [Association analysis of neuregulin 1 gene polymorphism with schizophrenia in Chinese Han population]
    Hong Xing Zhang
    Department of Psychiatry, The Second Affiliated Hospital, Xinxiang Medical College, Xinxiang, Henan 453002 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26:16-20. 2009
    To investigate the association of the Neuregulin 1(NRG1) gene polymorphism with schizophrenia by analyzing allele transmission in schizophrenic parent-proband trios.
  41. doi An association study of the neuregulin 1 gene, bipolar affective disorder and psychosis
    Diana P Prata
    Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Psychiatr Genet 19:113-6. 2009
    ..As the neuregulin 1 (NRG1) gene has been associated with schizophrenia, we set out to investigate whether it is also associated with bipolar ..
  42. doi Potential role of Neuregulin 1 and TNF-alpha (-308) polymorphism in schizophrenia patients visiting hospitals in Lahore, Pakistan
    Mamoona Naz
    Institute of Biochemistry and Biotechnology, University of the Punjab, Lahore 54590, Pakistan
    Mol Biol Rep 38:4709-14. 2011
    ..366) between the two groups. It was concluded that in Pakistani population the neuregulin 1 and tumor necrosis factor-α (-308) genes are strongly associated with schizophrenia...
  43. ncbi Neuregulin-1 (NRG-1) mRNA and protein in the adult human brain
    A J Law
    Neurosciences Building, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX, UK
    Neuroscience 127:125-36. 2004
    ..At the cellular level, NRG1 mRNA was abundant in hippocampal and cortical pyramidal neurons and some interneurons, and in cerebellar Purkinje ..
  44. doi Neuregulin-1 haplotype HAP(ICE) is associated with lower hippocampal volumes in schizophrenic patients and in non-affected family members
    Oliver Gruber
    Department of Psychiatry and Psychotherapy, Georg August University, Goettingen, Germany
    J Psychiatr Res 43:1-6. 2008
    The neuregulin-1 (NRG1) gene on chromosome 8p has been suggested as a potential susceptibility gene for schizophrenia...
  45. pmc Novel mechanism for negatively regulating Rho-kinase (ROCK) signaling through Coronin1B protein in neuregulin 1 (NRG-1)-induced tumor cell motility
    Manish K Rana
    Department of Pharmacology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70119, USA
    J Biol Chem 287:21836-45. 2012
    ..Our data support a model in which Coronin1B fine-tunes ROCK signaling to modulate myosin activity, which is important for tumor cell motility...
  46. ncbi Transcriptional control of cholesterol biosynthesis in Schwann cells by axonal neuregulin 1
    Maria Pertusa
    Instituto de Neurociencias de Alicante, UMH CSIC, Alicante, Spain
    J Biol Chem 282:28768-78. 2007
    ....
  47. ncbi Interleukin-1 beta gene polymorphism and its interactions with neuregulin-1 gene polymorphism are associated with schizophrenia
    Kari Hänninen
    Dept of Psychiatry, South Karelia Central Hospital, Valto Käkelän katu 14 C 6, Lappeenranta 53130, Finland
    Eur Arch Psychiatry Clin Neurosci 258:10-5. 2008
    ..46; p = 0.032). Our results suggest that there is an interaction between the IL-1B and NRG-1 genes in schizophrenia. In addition, the IL-1B-511 polymorphism seems to be associated with the age at onset of schizophrenia...
  48. pmc Neuregulin-1 beta and neuregulin-1 alpha differentially affect the migration and invasion of malignant peripheral nerve sheath tumor cells
    Jenell M Eckert
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    Glia 57:1501-20. 2009
    ..These findings suggest that NRG-1 beta enhances MPNST migration and that NRG-1 beta and NRG-1 alpha differentially modulate this process...
  49. pmc In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation
    Ketan Marballi
    Department of Cellular and Structural Biology and Psychiatry, University of Texas Health Sciences Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Mol Med (Berl) 88:1133-41. 2010
    Neuregulin 1 (NRG1) has been implicated in several disorders including breast cancer, multiple sclerosis, and schizophrenia. Also, recent evidence suggests that NRG1 may play a role in regulation of inflammation and immune system response...
  50. pmc Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling
    Katsuaki Ieguchi
    Department of Dermatology, University of California Davis School of Medicine, Sacramento, California 95817, USA
    J Biol Chem 285:31388-98. 2010
    ..We discovered that neuregulin-1 (NRG1), either as an isolated EGF-like domain or as a native multi-domain form, binds to integrins αvβ3 (with a K(D) of ..
  51. ncbi Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 growth factor receptors and their ligands, neuregulin-1 alpha, neuregulin-1 beta, and betacellulin, in normal endometrium and endometrial cancer
    R Srinivasan
    Receptor Biology Laboratory, Imperial Cancer Research Fund Molecular Oncology Unit, Imperial College School of Medicine, Hammersmith Campus, London, United Kingdom
    Clin Cancer Res 5:2877-83. 1999
    ..These results suggest that signaling through the c-erbB-3 and c-erbB-4 receptors and the ligands neuregulin alpha, neuregulin beta, and betacellulin are important in endometrial carcinogenesis...
  52. ncbi Neuregulin-1 activates the JAK-STAT pathway and regulates lung epithelial cell proliferation
    Jinbo Liu
    Department of Internal Medicine, Pulmonary and Critical Care Division, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Respir Cell Mol Biol 27:306-13. 2002
    ..This pathway plays an important role in NRG-1-stimulated proliferation of pulmonary epithelial cells...
  53. ncbi Neuregulin-1 and erbB4 immunoreactivity is associated with neuritic plaques in Alzheimer disease brain and in a transgenic model of Alzheimer disease
    Abhik Ray Chaudhury
    Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Neuropathol Exp Neurol 62:42-54. 2003
    ....
  54. ncbi Neuregulin-1 enhances motility and migration of human astrocytic glioma cells
    Patricia A Ritch
    Department of Neurobiology and Civitan International Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Biol Chem 278:20971-8. 2003
    ..Taken together these data suggest that neuregulin-1 plays an important modulatory role in glioma cell invasion...
  55. ncbi No association with the neuregulin 1 haplotype to Japanese schizophrenia
    N Iwata
    Mol Psychiatry 9:126-7. 2004
  56. ncbi Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder
    Elaine K Green
    Department of Psychological Medicine and Biostatics and Bioinformatics Unit, University of Wales College of Medicine, Cardiff
    Arch Gen Psychiatry 62:642-8. 2005
    ..Several studies have provided evidence that variation at the neuregulin 1 (NRG1) gene on chromosome 8p12 influences susceptibility to schizophrenia...
  57. ncbi Extreme population differences across Neuregulin 1 gene, with implications for association studies
    M Gardner
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Doctor Aiguader 80, 08003 Barcelona, Catalonia, Spain
    Mol Psychiatry 11:66-75. 2006
    Neuregulin 1 (NRG1) is one of the most exciting candidate genes for schizophrenia in recent years since its first association with the disease in an Icelandic population...
  58. ncbi Neuregulin 1 (NRG1 ) and schizophrenia: analysis of a US family sample and the evidence in the balance
    Jubao Duan
    Center for Psychiatric Genetics, Department of Psychiatry and Behavioral Sciences, Evanston Northwestern Healthcare Research Institute, and Northwestern University, 1001 University Place, Evanston, IL 60201, USA
    Psychol Med 35:1599-610. 2005
    ..A gene from this region, neuregulin 1 (NRG1 ), known to be involved with glutamatergic function, has been found to be associated in some studied samples.
  59. ncbi Supportive evidence for neuregulin 1 as a susceptibility gene for schizophrenia in a Japanese population
    Naoki Fukui
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachi ichibancho, Niigata 951 8510, Japan
    Neurosci Lett 396:117-20. 2006
    ..Recently, Stefansson et al. identified neuregulin 1 (NRG1) on 8p12 as a susceptibility gene for schizophrenia in the Icelandic population...
  60. ncbi No significant association of the 5' end of neuregulin 1 and schizophrenia in a large Danish sample
    Andres Ingason
    Research Institute of Biological Psychiatry, Copenhagen University Hospital, H S Sct Hans Hospital, DK 4000 Roskilde, Denmark
    Schizophr Res 83:1-5. 2006
    ..4, p = 0.12). The haplotype structure in the Danish sample was similar to that of other reported in other Caucasian populations and highly different from that of Chinese...
  61. ncbi Family-based association study of neuregulin-1 gene and psychosis in a Spanish sample
    Araceli Rosa
    Unitat de Biologia Evolutiva, Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra, Doctor Aiguader 88, 08003 Barcelona, Catalonia, Spain
    Am J Med Genet B Neuropsychiatr Genet 144:954-7. 2007
    Neuregulin 1 (NRG1) is one of the most exciting candidate genes for schizophrenia since its first association with the disorder in an Icelandic population...
  62. doi Neuregulin 1 ICE-single nucleotide polymorphism in first episode schizophrenia correlates with cerebral activation in fronto-temporal areas
    Tilo Kircher
    Dept of Psychiatry and Psychotherapy RWTH, University of Aachen, Pauwelsstr 30, 52074, Aachen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:72-9. 2009
    The Neuregulin (NRG1) gene has been associated with schizophrenia, but its functional implications are largely unknown...
  63. doi Neuregulin 1 and age of onset in the major psychoses
    Daphne Voineskos
    Centre for Addiction and Mental Health, 250 College Street, R 30, Toronto, ON, M5T 1R8, Canada
    J Neural Transm (Vienna) 116:479-86. 2009
    Genetic vulnerability to psychiatric illness extends across major psychiatric illness. Neuregulin 1 (NRG1) is a large gene on chromosome 8p, that has been identified as a susceptibility factor in bipolar disorder and schizophrenia...
  64. doi Genetic variation in the schizophrenia-risk gene neuregulin 1 correlates with brain activation and impaired speech production in a verbal fluency task in healthy individuals
    Tilo Kircher
    Department of Psychiatry and Psychotherapy, Philipps University Marburg, Rudolf Bultmann Str 8, 35039 Marburg, Germany
    Hum Brain Mapp 30:3406-16. 2009
    ..schizophrenia has a high heritability, it is of interest whether susceptibility genes for the disorder, such as NRG1, modulate verbal fluency performance and its neural correlates...
  65. pmc Analysis of a promoter polymorphism in the SMDF neuregulin 1 isoform in Schizophrenia
    Erika Pedrosa
    Division of Basic Research, Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuropsychobiology 59:205-12. 2009
    Neuregulin 1 (NRG1) is a positional candidate gene in schizophrenia (SZ). Two major susceptibility loci in the NRG1 gene approximately one million nucleotides apart have been identified in genetic studies...
  66. pmc Association of neuregulin 1 with schizophrenia confirmed in a Scottish population
    Hreinn Stefansson
    deCODE Genetics, Reykjavik, Iceland
    Am J Hum Genet 72:83-7. 2003
    Recently, we identified neuregulin 1 (NRG1) as a susceptibility gene for schizophrenia in the Icelandic population, by a combined linkage and association approach...
  67. ncbi Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia
    N M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, Wales CF14 4XN, UK
    Mol Psychiatry 8:485-7. 2003
    ..6%; P=0.019). Our results therefore replicate the Icelandic findings in an out-bred Northern European population, although they suggest that the risk conferred by the haplotype is small...
  68. ncbi A recurrent chromosome breakpoint in breast cancer at the NRG1/neuregulin 1/heregulin gene
    Huai En Huang
    Cancer Genomics Program, Hutchison MRC Research Centre, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    Cancer Res 64:6840-4. 2004
    ..We previously reported that five breast cancer cell lines have chromosome translocations that break in the NRG1 gene and that could cause abnormal NRG1 expression...
  69. ncbi Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia
    Dawei Li
    Bio X Center, Shanghai Jiao Tong University, Shanghai, China
    Hum Mol Genet 15:1995-2002. 2006
    ..an associated haplotype in the gene neuregulin 1 (NRG1), also known as heuregulin, glial growth factor, NDF43 and ARIA. A 290 kb core at risk haplotype at the 5' end of the gene (HAP(ICE)), defined by five SNPs and two microsatellite ..
  70. ncbi Association of Neuregulin 1 with schizophrenia and bipolar disorder in a second cohort from the Scottish population
    P A Thomson
    Department of Medical Sciences, Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Mol Psychiatry 12:94-104. 2007
    ..It spans a approximately 136 kb region that includes the coding sequence of the sensory and motor neuron derived factor (SMDF) isoform and 3' exons of all other known NRG1 isoforms...
  71. ncbi Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level
    Nicholas C Stefanis
    University Mental Health Research Institute, National and Kapodistrian University of Athens, Athens, Greece
    Biol Psychiatry 62:784-92. 2007
    ..It is unknown whether the expression of these endophenotypes at the population level is modulated by the genetic variability of candidate susceptibility genes for schizophrenia...
  72. doi A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia
    Szabolcs Keri
    Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 150:418-20. 2009
    ..These results raise the possibility that there is a significant gene by environment interaction regarding SNP8NRG243177/rs6994992 and psychosocial stress...
  73. ncbi Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin
    M X Sliwkowski
    Genentech, Inc, South San Francisco, California 94080
    J Biol Chem 269:14661-5. 1994
    The heregulin/neu differentiation factor gene products were purified and cloned based on their ability to stimulate the phosphorylation of a 185-kDa protein in human breast carcinoma cell lines known to express erbB2...
  74. ncbi Segregation of receptor and ligand regulates activation of epithelial growth factor receptor
    Paola D Vermeer
    Department of Internal Medicine, Howard Hughes Medical Institute, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    Nature 422:322-6. 2003
    ..This model also suggests a mechanism for abnormal receptor activation in diseases with increased epithelial permeability...
  75. ncbi Support for involvement of neuregulin 1 in schizophrenia pathophysiology
    T L Petryshen
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Mol Psychiatry 10:366-74, 328. 2005
    ..More recently, significant association with a candidate gene on 8p12, neuregulin 1 (NRG1), has been reported in several European and Chinese samples...
  76. ncbi Neurotrophic and neuroprotective effects of the neuregulin glial growth factor-2 on dopaminergic neurons in rat primary midbrain cultures
    Lixin Zhang
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky, USA
    J Neurochem 91:1358-68. 2004
    Glial growth factor-2 (GGF2) and other neuregulin (NRG) isoforms have been shown to play important roles in survival, migration, and differentiation of certain neural and non-neural cells...
  77. ncbi Neuregulins: versatile growth and differentiation factors in nervous system development and human disease
    Raymond M Esper
    Department of Neurology, Wayne State University, Detroit, MI 48201, USA
    Brain Res Rev 51:161-75. 2006
    ..of the neuregulin signaling system comes in part from a large number of alternatively-spliced forms of the NRG1 gene that can produce both soluble and membrane-bound forms...
  78. ncbi Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology
    Paul J Harrison
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 60:132-40. 2006
    Neuregulin 1 (NRG1) is a leading schizophrenia susceptibility gene...
  79. ncbi Association of the NRG1 gene and schizophrenia: a meta-analysis
    M R Munafò
    Department of Experimental Psychology, University of Bristol, Bristol, UK
    Mol Psychiatry 11:539-46. 2006
    We investigated the association of the NRG1 gene and schizophrenia using meta-analytic techniques, combining all published data while restricting our analysis to studies investigating the most commonly reported single marker (..
  80. pmc Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease
    Amanda J Law
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom
    Proc Natl Acad Sci U S A 103:6747-52. 2006
    Genetic variation in neuregulin 1 (NRG1) is associated with schizophrenia. The disease-associated SNPs are noncoding, and their functional implications remain unknown...
  81. ncbi Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia
    Chang Gyu Hahn
    Cellular and Molecular Neuropathology Program, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Med 12:824-8. 2006
    Recent molecular genetics studies implicate neuregulin 1 (NRG1) and its receptor erbB in the pathophysiology of schizophrenia...
  82. ncbi Immunohistochemical evidence for impaired neuregulin-1 signaling in the prefrontal cortex in schizophrenia and in unipolar depression
    Iris Bertram
    Exp Psychiatry Lab, University of Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Ann N Y Acad Sci 1096:147-56. 2007
    ..Reduced NRG-1alpha protein concentrations were found in brains of schizophrenics after Western blot analysis. The diminished expression of NRG-1alpha strongly supports an early neurodevelopmental component to schizophrenia...
  83. ncbi Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia
    Wei Tan
    SAIC Frederick, NCI, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 282:24343-51. 2007
    Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia...
  84. doi Support for neuregulin 1 as a susceptibility gene for bipolar disorder and schizophrenia
    Lyudmila Georgieva
    Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
    Biol Psychiatry 64:419-27. 2008
    There is support that Neuregulin 1 (NRG1) plays a role in susceptibility to schizophrenia but limited evidence for its involvement in bipolar disorder...
  85. pmc Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins
    Yun Bian
    Cardiovascular Research, Caritas St Elizabeth s Medical Center, 736 Cambridge St CBR3, Boston, MA 02135, USA
    Am J Physiol Heart Circ Physiol 297:H1974-83. 2009
    Neuregulin-1 (NRG1) is a potential therapeutic agent for the treatment of doxorubicin (Dox)-induced heart failure. NRG1, however, activates the erbB2 receptor, which is frequently overexpressed in breast cancers...
  86. pmc Schizophrenia-related neuregulin-1 single-nucleotide polymorphisms lead to deficient smooth eye pursuit in a large sample of young men
    Nikolaos Smyrnis
    Psychiatry Department, National and Kapodistrian University of Athens Medical School, Eginition Hospital, 72 Vas Sofias Avenue, Athens, Greece
    Schizophr Bull 37:822-31. 2011
    Neuregulin-1 (NRG1) variations have been shown to modulate schizophrenia candidate endophenotypes related to brain structure and function...
  87. doi Association of Neuregulin 1 rs3924999 genotype with antisaccades and smooth pursuit eye movements
    A Schmechtig
    Department of Neuroimaging, King s College Institute of Psychiatry, London, UK
    Genes Brain Behav 9:621-7. 2010
    Neuregulin 1 (NRG1) has been identified as one of the leading candidate genes for schizophrenia. However, its functional mechanisms and its effects on neurocognition remain unclear...
  88. doi Neuregulin-1 genotype is associated with structural differences in the normal human brain
    Anna Barnes
    Department of Psychiatry, University of Cambridge, Box 189 Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Neuroimage 59:2057-61. 2012
    ..These results suggest that this genetic variant may mediate risk for schizophrenia, in part, through its effect on brain structure in these regions...
  89. pmc The importance of the NRG-1/ErbB4 pathway for synaptic plasticity and behaviors associated with psychiatric disorders
    Alon Shamir
    Section on Molecular Neurobiology, Eunice Shriver Kennedy National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    J Neurosci 32:2988-97. 2012
    ..These findings are important to better understand ErbB4's role in complex behaviors and warrant further analysis of ErbB4 mutant mice lacking the receptor in distinct neuron types...
  90. doi Aberrant high expression of NRG1 gene in Hirschsprung disease
    Weibing Tang
    State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China
    J Pediatr Surg 47:1694-8. 2012
    ..Recent studies have indicated the potential function of neuregulin-1 (NRG1) in HSCR, which encodes the heregulins and other mitogenic ligands for the ErbB family...
  91. ncbi Identification of heregulin, a specific activator of p185erbB2
    W E Holmes
    Department of Protein Chemistry, Genentech, Inc, South San Francisco, CA 94080
    Science 256:1205-10. 1992
    ..A 45-kilodalton protein heregulin-alpha (HRG-alpha) that specifically induced phosphorylation of p185erbB2 was purified from the conditioned medium of a human ..
  92. pmc Neural expression and chromosomal mapping of Neu differentiation factor to 8p12-p21
    A Orr-Urtreger
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    Proc Natl Acad Sci U S A 90:1867-71. 1993
    b>Neu differentiation factor (NDF/heregulin) is a 44-kDa glycoprotein that interacts with the Neu/ErbB-2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues...
  93. ncbi Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system
    M A Marchionni
    Cambridge NeuroScience Inc, Massachusetts 02139
    Nature 362:312-8. 1993
    ..These factors are probably important in the development and regeneration of the nervous system...
  94. ncbi Gamma-heregulin: a novel heregulin isoform that is an autocrine growth factor for the human breast cancer cell line, MDA-MB-175
    G Schaefer
    Genentech, Inc, South San Francisco, California 94080, USA
    Oncogene 15:1385-94. 1997
    A novel neuregulin isoform, termed gamma-HRG, was cloned and characterized from the human breast cancer cell line, MDA-MB-175...
  95. ncbi Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes
    Y Y Zhao
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:10261-9. 1998
    Neuregulins (i.e. neuregulin-1 (NRG1), also called neu differentiation factor, heregulin, glial growth factor, and acetylcholine receptor-inducing activity) are known to induce growth and differentiation of epithelial, glial, neuronal, ..
  96. ncbi Gamma-heregulin: a fusion gene of DOC-4 and neuregulin-1 derived from a chromosome translocation
    X Liu
    Victor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia
    Oncogene 18:7110-4. 1999
    ..We conclude, therefore, that gamma-heregulin is not a native isoform of the neuregulin-1 gene, but a novel growth factor that may contribute to tumour cell proliferation...
  97. ncbi The N-terminal region of neuregulin isoforms determines the accumulation of cell surface and released neuregulin ectodomain
    J Y Wang
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 276:2841-51. 2001
    ....
  98. ncbi Roles of Meltrin beta /ADAM19 in the processing of neuregulin
    K Shirakabe
    Department of Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    J Biol Chem 276:9352-8. 2001
    ..Furthermore, the effects of the secretory pathway inhibitors suggested that meltrin beta participates in the intracellular processing of NRGs rather than the cleavage on the cell surface...
  99. ncbi Molecular determinants of the sensory and motor neuron-derived factor insertion into plasma membrane
    Hugo Cabedo
    Centro de Biologia Molecular y Celular and Instituto de Neurociencias Consejo Superior de Investigaciones Cientificas, Universidad Miguel Hernandez, Alicante 03202, Spain
    J Biol Chem 277:19905-12. 2002
    The sensory and motor neuron-derived factor (SMDF) is a type III neuregulin that regulates development and proliferation of Schwann cells...
  100. pmc Neuregulin 1 and susceptibility to schizophrenia
    Hreinn Stefansson
    deCODE Genetics, Reykjavik, Iceland
    Am J Hum Genet 71:877-92. 2002
    ..and haplotype-association analysis, supplemented by a transmission/disequilibrium test, identifies neuregulin 1 (NRG1) as a candidate gene for schizophrenia...
  101. ncbi Heregulin is sufficient for the promotion of tumorigenicity and metastasis of breast cancer cells in vivo
    Ella Atlas
    Evanston Northwestern Healthcare Research Institute, Northwestern University, Evanston, IL 60201, USA
    Mol Cancer Res 1:165-75. 2003
    ..Heregulin (HRG) is a pleiotropic growth factor that binds to the erbB family of receptors, which are correlated with breast cancer ..

Research Grants67

  1. Molecular Basis of Neuron-Gila Interactions in the CNS
    Gabriel Corfas; Fiscal Year: 2009
    ..It has been proposed that the trophic factor neuregulin 1 (NRG1) and its receptors, the erbB receptor tyrosine kinases, regulate important aspects of OL development...
  2. Mechanisms of schizophrenia-like phenotypes in BACE 1 knockout mice
    Alena Savonenko; Fiscal Year: 2010
    ..Recently, changes in BACE1-dependent proteolytic processing of neuregulin 1 (NRG1) have been linked to deficits in central and peripheral myelination in BACE1-/- mice...
  3. NANCY MEIYUN CHIU BIVENS; Fiscal Year: 2014
    ..Using genetic and developmental methods to alter expression of Nrg1 in mice, this proposal will undertake behavioral and neuropathological analyses relevant to psychosis...
  4. Developmental role of Neuregulin-1 in subventricular zone stem cell fate
    Heather El-Amamy; Fiscal Year: 2013
    ..A genetic mutation in Nrg1 is sufficient to reproduce these olfactory deficits in mice...
  5. David L Braff; Fiscal Year: 2015
    ..The genetic architecture of each IB in schizophrenia patients will be examined, focusing on 3 genes - NRG1;ERBB4;and COMT - together with other secondary genes of interest, based on preliminary association findings and/or ..
  6. Role of neuregulin 1 signaling in cortical maturation and schizophrenia
    Yachi Chen; Fiscal Year: 2013
    Neuregulin 1 (NRG1) is a schizophrenia susceptibility gene...
  7. EXPRESSION OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS
    Lorna Role; Fiscal Year: 2009
    ..that regulates the expression and distribution of neuronal nAChRs -- a neuregulin 1 splice-isoform, called CRD-Nrg1. Recent work demonstrates that CRD-Nrg1 is essential for the maintenance of specific peripheral cholinoceptive ..
  8. Generation and Characterization of GAD67-ErbB4 Transgenic Mice
    Lin Mei; Fiscal Year: 2010
    ..Such an approach has proved useful in generating and analyzing schizophrenic rodent models. Both neuregulin-1 (NRG1) and its receptor ErbB4 are susceptibility genes of schizophrenia...
  9. Larry J Siever; Fiscal Year: 2015
    ..A number of susceptibility genes are implicated in white abnormalities and schizophrenia including neuregulin 1 (NRG1) and ERBB4...
  10. Neuregulin 1 signaling and schizophrenia: effect of transmembrane domain variants
    David A Talmage; Fiscal Year: 2012
    ..Although the NRG1 gene has been repeatedly linked to schizophrenia susceptibility, the majority of sequence polymorphisms that are ..
  11. Neuregulin 1 signaling and schizophrenia: effect of transmembrane domain variants
    David A Talmage; Fiscal Year: 2013
    ..Although the NRG1 gene has been repeatedly linked to schizophrenia susceptibility, the majority of sequence polymorphisms that are ..
  12. Lin Mei; Fiscal Year: 2016
    Our long-term goal is to understand the role of neuregulin1 (NRG1) and its receptor ErbB4 in neurotransmission, allowing for an improved understanding of their contribution to pathophysiology of schizophrenia...
  13. Riqiang Yan; Fiscal Year: 2016
    ..the release of A, this inhibition will also lead to decrease cleavage of another BACE1 substrate, neuregulin-1 (Nrg1), and will reduce its signaling activity, which regulates various central nervous system functions such as ..
  14. Iqbal Hamza; Fiscal Year: 2016
    ..Utilizing C. elegans as a genetic animal model of heme auxotrophy, we identified HRG-1, the first eukaryotic heme importer/ transporter (Nature 2008)...
  15. BACE1-NEUREGULIN-ErbB4 SIGNALING IN OLFACTORY MODELS OF PSYCHOSIS
    Vassilis E Koliatsos; Fiscal Year: 2010
    ..The central hypothesis of this proposal is that BACE1- neuregulin 1 (NRG1)-ErbB4 signaling is critical for the ongoing remodeling of piriform cortex, primarily by affecting the induction ..
  16. Defining of Neurodevelopmental Pathways Regulated by Neuregulin- DISC1 Interactio
    Akira Sawa; Fiscal Year: 2010
    ..Two of the strongest susceptibility genes for Schizophrenia are neuregulin 1 (NRG1) and DISC1...
  17. Novel Regenerative Therapy for Myocardial Infarction
    Andrew R Mendelsohn; Fiscal Year: 2011
    ..2010). [These additional functions contribute to NRG1's ability to repair damaged cardiac tissue...
  18. Gabriel Corfas; Fiscal Year: 2016
    ..receptor signaling induces NT expression in other non-neuronal cells, and since inner ear sensory neurons express NRG1, we hypothesize that: NRG1, produced by cochlear and vestibular sensory neurons, induces supporting cells to ..
  19. Caveolin-1 and Altered Neuregulinism in Diabetic Neuropathy
    Rick T Dobrowsky; Fiscal Year: 2012
    ..Neuregulin-1 (NRG1) is a gliotrophic growth factor that promotes cell survival, mitogenesis and myelination by activating Erb B ..
  20. HILARY PATRICIA BLUMBERG; Fiscal Year: 2015
    ..Moreover, the data implicate a gene associated with WM development, neuregulin 1 (NRG1), in influencing FT WM integrity in BD...
  21. James Salzer; Fiscal Year: 2016
    ..We are investigating the role of neuregulin-1 (NRG1), a neuronal growth factor which regulates the entire Schwann cell lineage, including the binary choice between ..
  22. Novel Treatment of NF-1 Associated Malignant Peripheral Nerve Sheath Tumors
    Steven L Carroll; Fiscal Year: 2012
    ..Inappropriate stimulation by growth factors is thought to cooperate with mutations of tumor suppressor genes such as NF1 and p53 to promote MPNST tumorigenesis. ..
  23. THE NEUREGULINS IN ADULT NEUROGENESIS AND MIGRATION
    Cary Lai; Fiscal Year: 2009
    ..We have shown that ErbB4 is expressed in these migrating progenitors and that neuregulin-1 (NRG1) is the most readily detected ErbB4 ligand expressed in the RMS...
  24. Neuregulin-1 and Neurovascular Protection
    JOSEPHINE MUN YEE LOK; Fiscal Year: 2013
    ..We have found that neuregulin-1 (NRG1), an endogenous growth factor, enhances endothelial production of BDNF, promotes angiogenesis, and protects brain ..
  25. Mechanisms of neuregulin 1 protection of excitatory neurons in stroke models
    Lin Mei; Fiscal Year: 2013
    ..The mechanisms underlying the relative resistance of interneurons to cerebral ischemia are unknown. Neuregulin 1 (NRG1) is a trophic factor that has been implicated in neural development and neurotransmission...
  26. Mark S Kindy; Fiscal Year: 2014
    ..membrane anchored alpha-secretase substrates, heparin binding-epidermal growth factor (HB-EGF) and neuregulin-1 (NRG1). We also show that Fbln1 acts to inhibit the proteolytic release of soluble forms of HB-EGF and NRG1...
  27. TUMOR CELL LINE PROLIFERATION, MOTILITY AND INVASIVENESS
    DAVID RIESE; Fiscal Year: 2000
    ..Another EGF family hormone, Neuregulin-1 (NRG1), induces tumor cell differentiation and growth arrest...
  28. NEUREGULINS AND THEIR RECEPTORS IN LUNG DEVELOPMENT
    CHRISTIANE DAMMANN; Fiscal Year: 2005
    ..We have strong evidence that Neuregulin-1 (NRG1), a stromal-derived growth factor previously implicated in mammary gland epithelial cell maturation, is a critical ..
  29. Generation and Characterization of GAD67-ErbB4 Transgenic Mice
    Lin Mei; Fiscal Year: 2009
    ..Such an approach has proved useful in generating and analyzing schizophrenic rodent models. Both neuregulin-1 (NRG1) and its receptor ErbB4 are susceptibility genes of schizophrenia...
  30. In vivo studies of Neuregulin 1 in addiction pathways
    Lorna Role; Fiscal Year: 2006
    ..Likewise, genetic variants of Neuregulin 1 (Nrg1), a key regulator of (a7*-nAChRs), have recently been associated with heritab e forms of SZ...
  31. Steven J Siegel; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Recent molecular genetics studies implicate neuregulin 1 (NRG1) and its receptor, erbB, in the pathophysiology of schizophrenia...
  32. NRG1 MICE: TOOLS TO UNRAVEL THE LINK TO SCHIZOPHRENIA
    Cary Lai; Fiscal Year: 2005
    ..Recently, neuregulin-1 (NRG1) was identified as the susceptibility gene present at the 8p locus...
  33. Behavioral aspects of NRG1 hypomorphic mice
    Robert Merker; Fiscal Year: 2004
    Neuregulin-1 (NRG1) has been identified as a schizophrenia susceptibility gene using linkage and haplotype analysis...
  34. Animal Models of Schizophrenia: NRG-erbB Function
    Daniela Brunner; Fiscal Year: 2005
    ..In light of the recently found association of the neuregulin 1 (NRG1) gene and this disorder, we propose to investigate two lines of transgenic mice in which the function of the NRG ..
  35. KRISTINA MARIE UTZSCHNEIDER; Fiscal Year: 2015
    ..Therefore, high GL (HGL) diets could be potentially damaging to the beta-cell by increasing glucose fluctuations and oxidative stress...
  36. Herbert M Lachman; Fiscal Year: 2016
    ..significant enrichment for SZ and ASD candidate genes was found, which included A2BP1 (RBFOX1), ERBB4, NLGN4X, NRG1, NRG3, NRXN1, and NLGN1...
  37. Mechanism and neurodevelopmental role of DISC 1 and NRG/ErbB signaling cross-tal
    SAURAV RAO SESHADRI; Fiscal Year: 2010
    ..DISC1 and NRG1 are both major susceptibility genes for SZ, and preliminary data indicates that NRG1 signaling can affect ..
  38. Functions of DISC1 and APP in Cortical Development and Neuropsychiatric Disorders
    Tracy L Young-Pearse; Fiscal Year: 2013
    ..In addition, several genes have been linked to schizophrenia such as D1SC1, PDE4, and NRG1, all of which play important roles in neuronal development, including migration and neurite outgrowth...
  39. Functions of DISC1 and APP in Cortical Development and Neuropsychiatric Disorders
    Tracy L Young Pearse; Fiscal Year: 2010
    ..In addition, several genes have been linked to schizophrenia such as DISC1, PDE4, and NRG1, all of which play important roles in neuronal development, including migration and neurite outgrowth...
  40. PAVEL LEON KATSEL; Fiscal Year: 2016
    ..population of glial progenitor cells targeted by DhDISC1 expression;(2) examining molecular pathways (elicited by NRG1, IGF1 and Wnt) that may mediate the effect of DhDISC1 on migration, proliferation and differentiation of OPC by ..
  41. Paul J Lombroso; Fiscal Year: 2015
    ..Aim 2 will test our hypothesis in an animal model of SZ (NRG1 mice). NRG1 mice have decreased functional NMDARs on neuronal surfaces...
  42. Robert A Sweet; Fiscal Year: 2016
    ..found evidence of association of AD+P with genetic variation in the putative schizophrenia risk gene, neuregulin1 (NRG1), which we demonstrated impacts expression of mRNA transcripts of novel NRG1 exons...
  43. ERBB4 in the Normal and Neoplastic Breast
    Frank E Jones; Fiscal Year: 2013
    ..On the other hand an ERBB4 ligand, HRG, promotes 4ICD translocation to mitochondria where 4ICD induces tumor cell apoptosis by functioning as a novel BH3-..
  44. Mechanisms of Heme Transport in Macrophages
    CARINE CARINE WHITE; Fiscal Year: 2012
    ..Our laboratory has identified the first eukaryotic heme importer/transporter HRG-1, using the genetic animal model Caenorhabditis elegans (Nature 2008)...
  45. ARIA II FLOW CYTOMTR: 3 LASER VIOW/ACDU
    Weimin Zhong; Fiscal Year: 2010
    ....
  46. REGULATION OF FILAMENTOUS GROWTH IN YEAST
    Haoping Liu; Fiscal Year: 2013
    ..We find cAMP- PKA dependent down-regulation of the major repressor of hyphal morphogenesis, Nrg1, correlates with the initiation of the hyphal transcriptional program...
  47. David R Sherman; Fiscal Year: 2016
    ..DESCRIPTION (as provided by applicant): Project 1 will apply systems approaches to identify Host Regulatory Gene (HRG) networks that determine the balance between asymptomatic MTB infection and TB disease progression...
  48. Heregulin signaling via small GTPases in mitogenesis and tumorigenesis
    MARCELO GABRIEL KAZANIETZ; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Approximately 30% of breast tumors express high levels of heregulins (HRG), a group of epidermal growth factor (EGF)-like ligand peptides that induce the progression towards an aggressive and ..
  49. Environmental Conditions Control Filamentation and Virulence in Candida albicans
    DELMA CHILDERS; Fiscal Year: 2012
    ..Our studies will focus on Ume6, Nrg1 and Rfg1, key transcription factors that regulate hyphal- specific gene expression and filamentation...
  50. Allopregnanolone Regenerative Therapeutic for MCI/AD: Dose Finding Phase I
    Lon S Schneider; Fiscal Year: 2013
    ..events;4) clinically important changes in safety assessments including amyloid related imaging abnormalities (ARIA)...
  51. Neuregulin1 Alleviation of the "On-Target" Cardiotoxicity Caused by Inhibition of
    Xinhua Yan; Fiscal Year: 2013
    ..Our objective is to test a novel method using Neuregulin1 (NRG1), a ligand of the HER receptors, to prevent the severe cardiotoxicity caused by therapies that concurrently use ..
  52. Richard A Cerione; Fiscal Year: 2016
    ..that are regulated through the actions of EGF, a primary ligand/growth factor for the EGFR, and Heregulin (HRG), a ligand for EGFR family members ErbB3 and ErbB4 and an activator of the ErbB2/Neu tyrosine kinase...
  53. Development of a Novel Therapeutic for Alzheimer'Disease
    MARK ANTHONY LOVELL; Fiscal Year: 2012
    ..we hypothesize that NFD-L does not lead to microhemorrhages or edema (amyloid related imaging abnormalities;ARIA) that are associated with immunotherapy mediated A? clearance...
  54. Soluble Neuregulins in Neuromuscular and Peripheral Nerve Development
    Jeffrey A Loeb; Fiscal Year: 2013
    ..Given the close proximity of the axon to both muscle and Schwann cell targets, the direct and indirect effects of NRG1 on muscle and nerve have been difficult to establish...
  55. Mark D Fleming; Fiscal Year: 2016
    ..Our preliminary in vitro and in vivo data strongly suggest that the mammalian ortholog of hrg-1, HRG1, is involved in macrophage iron recycling, intestinal heme absorption, as well as intraerythroid and hepatocellular ..
  56. Iqbal Hamza; Fiscal Year: 2016
    ..elegans. The studies in this proposal will test the hypothesis that HRG-7 and HRG-8 communicate and integrate intestinal heme status with extraintestinal tissues by initiating a feedback ..
  57. FACS Aria II Three Laser Special Order System
    CHARLES ARTHUR KUSZYNSKI; Fiscal Year: 2010
    ..facility requests funds to replace its FACS Vantage SE flow cytometer/cell sorter (which is obsolete) with a FACS Aria II three laser special order system...
  58. Kumuda C Das; Fiscal Year: 2014
    ..leads to the Specific Aims of this proposal: Aim 1 will determine the role of Trx in endothelial apoptosis due to NRG1[unreadable]/ErbB4 signaling;Aim 2 will explore potential mechanisms of these effects as it related to Nox4 ..
  59. A Novel Mechanism for Control of Androgen Receptor Levels in HRPC
    Anne W Hamburger; Fiscal Year: 2013
    ..The ability of EBP1 to repress AR function can be regulated by the ErbB3/4 ligand heregulin (HRG) an important modulator of prostate cancer cell growth...
  60. Regulation of epitheliopoiesis in the olfactory epithelium by Neuregulin signalin
    Melissa Donovan; Fiscal Year: 2013
    ..The ErbB receptor family binding protein, Neuregulin1 (Nrg1), has been found to be secreted by LP cells and has been shown to be capable of inducing OE stem cell ..
  61. High Throughput Screen Development for Modulators of Heme Transporters
    Iqbal Hamza; Fiscal Year: 2011
    ..elegans. Using C. elegans, the PI recently identified the HRG-1 family of proteins, the first bona fide metazoan heme importers/transporters...
  62. Role of hemodynamics and ErbB signaling in cardiac trabeculation
    Jiandong Liu; Fiscal Year: 2012
    ..on these findings to test the hypotheses that (1) activation of Notch signaling by blood flow induces neuregulin1 (nrg1) expression in the endocardium, and (2) Nrg1 activates its ErbB receptors in the myocardium to initiate ..
  63. Clinical Knowledge Hub - Conceptual Integration of Rules, Data Sets, and Queries
    Gunther Schadow; Fiscal Year: 2010
    ..Automation (CHICA) system;(iv) FDA/NLM published Structured Product Labels (SPL) enhanced with the VA's NDF-RT medication knowledge base, (v) Clinical data sets and templates published by various continuity of care projects ..
  64. Jiandong Liu; Fiscal Year: 2015
    ..on these findings to test the hypotheses that (1) activation of Notch signaling by blood flow induces neuregulin1 (nrg1) expression in the endocardium, and (2) Nrg1 activates its ErbB receptors in the myocardium to initiate ..