NR2B

Summary

Gene Symbol: NR2B
Description: glutamate ionotropic receptor NMDA type subunit 2B
Alias: EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, hNR3, glutamate receptor ionotropic, NMDA 2B, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NR3, glutamate [NMDA] receptor subunit epsilon-2, glutamate receptor subunit epsilon-2, glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Species: human

Top Publications

  1. pmc Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential
    Laetitia Mony
    Laboratoire de Neurobiologie, Ecole Normale Superieure, CNRS, Paris, France
    Br J Pharmacol 157:1301-17. 2009
  2. ncbi Presynaptic NR2B-containing NMDA autoreceptors mediate gluta-matergic synaptic transmission in the rat visual cortex
    Yan Hai Li
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi an Jiaotong University, Xi an, Shaanxi 710049, P R China
    Curr Neurovasc Res 6:104-9. 2009
  3. pmc Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons
    Michael A Beazely
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 284:8054-63. 2009
  4. doi Late phase of long-term potentiation induced by co-application of N-methyl-d-aspartic acid and the antagonist of NR2B-containing N-methyl-d-aspartic acid receptors in rat hippocampus
    A Oh-Nishi
    Division of Brain Science, Kitasato University Graduate School of Medical Sciences, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Neuroscience 159:127-35. 2009
  5. pmc The effects of NR2 subunit-dependent NMDA receptor kinetics on synaptic transmission and CaMKII activation
    David M Santucci
    Department of Neurobiology, Duke University Medical Center, Durham, NC, USA
    PLoS Comput Biol 4:e1000208. 2008
  6. ncbi Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex
    K Jo
    Department of Physiology, School of Medicine, University of California at San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 19:4189-99. 1999
  7. ncbi Phosphorylation-dependent interaction of the N-methyl-D-aspartate receptor epsilon 2 subunit with phosphatidylinositol 3-kinase
    C Hisatsune
    Department of Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Genes Cells 4:657-66. 1999
  8. ncbi Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor
    R V Omkumar
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 271:31670-8. 1996
  9. ncbi Regional, developmental and interspecies expression of the four NMDAR2 subunits, examined using monoclonal antibodies
    D J Laurie
    ZMBH, University of Heidelberg, Germany
    Brain Res Mol Brain Res 51:23-32. 1997
  10. ncbi Genetic enhancement of learning and memory in mice
    Y P Tang
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
    Nature 401:63-9. 1999

Research Grants

  1. Roles for gliotransmisssion in seizure-related disorders
    Philip G Haydon; Fiscal Year: 2010
  2. MOLECULAR STUDIES OF BRAIN NMDA RECEPTORS
    R Suzanne Zukin; Fiscal Year: 2009
  3. Immunity to brain Ma proteins: A remote effect of cancer
    Josep Dalmau; Fiscal Year: 2007
  4. Steroids-Functional Modulators of Amino Acid Receptors
    DAVID FARB; Fiscal Year: 2007
  5. Stephen Traynelis; Fiscal Year: 2016
  6. Shinghua Ding; Fiscal Year: 2014
  7. Role of CREST in cortical development and plasticity
    Massimo Scanziani; Fiscal Year: 2013
  8. Xin Yun Lu; Fiscal Year: 2016
  9. ETHANOL, NEUROSTEROIDS &HIPPOCAMPAL PLASTICITY
    Charles F Zorumski; Fiscal Year: 2013
  10. Dopamine's Role in the Rapid Estradiol Enhancement of Excitatory Synapses
    CAROLINE COFER SMITH HAMILTON; Fiscal Year: 2013

Detail Information

Publications309 found, 100 shown here

  1. pmc Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential
    Laetitia Mony
    Laboratoire de Neurobiologie, Ecole Normale Superieure, CNRS, Paris, France
    Br J Pharmacol 157:1301-17. 2009
    ..The present review focuses on allosteric modulation of NMDARs containing the NR2B subunit...
  2. ncbi Presynaptic NR2B-containing NMDA autoreceptors mediate gluta-matergic synaptic transmission in the rat visual cortex
    Yan Hai Li
    The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi an Jiaotong University, Xi an, Shaanxi 710049, P R China
    Curr Neurovasc Res 6:104-9. 2009
    ..Using a specific antagonist for NR2B-NMDA-Rs, (alphaR,betaS)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride (Ro ..
  3. pmc Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons
    Michael A Beazely
    Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 284:8054-63. 2009
    ..hippocampus, the majority of NMDA receptors are heteromeric; most are composed of 2 NR1 subunits and 2 NR2A or 2 NR2B subunits...
  4. doi Late phase of long-term potentiation induced by co-application of N-methyl-d-aspartic acid and the antagonist of NR2B-containing N-methyl-d-aspartic acid receptors in rat hippocampus
    A Oh-Nishi
    Division of Brain Science, Kitasato University Graduate School of Medical Sciences, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Neuroscience 159:127-35. 2009
    ..a brief bath co-application of a low concentration of NMDA, an agonist of NMDARs, and the selective antagonist of NR2B-containing NMDARs, (alpha R, beta S)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanol (..
  5. pmc The effects of NR2 subunit-dependent NMDA receptor kinetics on synaptic transmission and CaMKII activation
    David M Santucci
    Department of Neurobiology, Duke University Medical Center, Durham, NC, USA
    PLoS Comput Biol 4:e1000208. 2008
    ..Subtypes of the NMDA receptor NR2 subunit are differentially expressed during development; in the forebrain, the NR2B receptor is dominant early in development, and later both NR2A and NR2B are expressed...
  6. ncbi Characterization of MALS/Velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95/NMDA receptor postsynaptic complex
    K Jo
    Department of Physiology, School of Medicine, University of California at San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 19:4189-99. 1999
    ..This work suggests a role for MALS proteins in regulating recruitment of neurotransmitter receptors to the PSD...
  7. ncbi Phosphorylation-dependent interaction of the N-methyl-D-aspartate receptor epsilon 2 subunit with phosphatidylinositol 3-kinase
    C Hisatsune
    Department of Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Genes Cells 4:657-66. 1999
    ....
  8. ncbi Identification of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor
    R V Omkumar
    Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 271:31670-8. 1996
    ..L., and MacDonald, J. F. (1994) Nature 369, 230-232). Here we identify a major phosphorylation site on subunit NR2B that is phosphorylated by Ca2+/calmodulin-dependent protein kinase II (CaM kinase II), an abundant protein kinase ..
  9. ncbi Regional, developmental and interspecies expression of the four NMDAR2 subunits, examined using monoclonal antibodies
    D J Laurie
    ZMBH, University of Heidelberg, Germany
    Brain Res Mol Brain Res 51:23-32. 1997
    Mouse monoclonal antibodies were raised against bacterially expressed protein sequences of the NR2A, NR2B, NR2C and NR2D subunits of the rat NMDA receptor...
  10. ncbi Genetic enhancement of learning and memory in mice
    Y P Tang
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
    Nature 401:63-9. 1999
    ..Here we show that overexpression of NMDA receptor 2B (NR2B) in the forebrains of transgenic mice leads to enhanced activation of NMDA receptors, facilitating synaptic ..
  11. ncbi Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current
    G Y Liao
    Laboratory of Integrative Neuroscience, Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA
    Mol Pharmacol 59:960-4. 2001
    ..Experiments using chimeras initially indicated that the cytoplasmic C-terminal tails of NR2B (responsive to PKC) and NR2C (unresponsive to PKC) subunits contain the amino acid residues responsible for the ..
  12. ncbi Mutation analysis of the NMDAR2B (GRIN2B) gene in schizophrenia
    T Ohtsuki
    Department of Medical Genetics, Institute of Basic Medical Sciences, University of Tsukuba, 305 8575, Ibaraki, Japan
    Mol Psychiatry 6:211-6. 2001
    ..on this hypothesis, we screened 48 Japanese patients with schizophrenia for mutations in the coding region of the NMDAR2B subunit gene (GRIN2B)...
  13. ncbi HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity
    N J Haughey
    Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland, USA
    J Neurochem 78:457-67. 2001
    ..Tat increased 32P incorporation into NMDA receptor subunits NR2A and NR2B and this effect was blocked by genestein...
  14. ncbi NR2A and NR2B receptor gene variations modify age at onset in Huntington disease
    Larissa Arning
    Department of Human Genetics, Ruhr University Bochum, Universitatsstrasse 150, 44801 Bochum, Germany
    Neurogenetics 6:25-8. 2005
    ..5% to GRIN2A genotype variation. We conclude that these two genes, coding for NR2B and NR2A subtypes mainly expressed in the striatum, may influence the variability in AO of HD...
  15. ncbi Human T lymphocytes express N-methyl-D-aspartate receptors functionally active in controlling T cell activation
    Gianluca Miglio
    DISCAFF Department, Eastern Piedmont University, Via Bovio 6, 28100 Novara, Italy
    Biochem Biophys Res Commun 338:1875-83. 2005
    ..that human resting peripheral blood lymphocytes (PBL) and Jurkat T cells express genes encoding for both NR1 and NR2B subunits: phytohemagglutinin (PHA)-activated PBL also expresses both these genes and the NR2A and NR2D genes...
  16. ncbi N-methyl-D-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levels
    Livia Martucci
    Neurogenetics Section, CAMH, Clarke Division, University of Toronto, R 31, 250 College Street, Toronto ON, Canada M5T 1R8
    Schizophr Res 84:214-21. 2006
    The NR2B protein is a critical structural and functional subunit of the NMDA glutamate receptor...
  17. pmc Association of the glutamate receptor subunit gene GRIN2B with attention-deficit/hyperactivity disorder
    K M Dorval
    Cell and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Genes Brain Behav 6:444-52. 2007
    ..Our data suggest an association between variations in the GRIN2B subunit gene and ADHD as measured categorically or as a quantitatively distributed trait...
  18. pmc HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes
    Eliseo A Eugenin
    Department of Pathology and Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:3438-43. 2007
    ..These findings implicate the complex in HIV-induced neuronal apoptosis and suggest therapeutic targets for intervention in the pathogenesis of NeuroAIDS...
  19. ncbi NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner
    Larissa Arning
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    Hum Genet 122:175-82. 2007
    ..g. variations in the NR2A and NR2B glutamate receptor subunit genes (GRIN2A, GRIN2B)...
  20. ncbi Quantitative hypermethylation of NMDAR2B in human gastric cancer
    Jun Wei Liu
    Department of Otolaryngology, Division of Head and Neck Cancer Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Int J Cancer 121:1994-2000. 2007
    NMDA receptor Type 2B (NMDAR2B) is a candidate TSG first identified in esophageal squamous cell carcinoma (ESCC)...
  21. ncbi Association analysis of polymorphisms in the N-methyl-D-aspartate (NMDA) receptor subunit 2B (GRIN2B) gene and tardive dyskinesia in schizophrenia
    Ying Jay Liou
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Psychiatry Res 153:271-5. 2007
    ..We conclude that genetic variations in the human GRIN2B gene probably do not play a major role in susceptibility to, or severity of TD...
  22. ncbi Stage II follow-up on a linkage scan for bipolar disorder in the Ashkenazim provides suggestive evidence for chromosome 12p and the GRIN2B gene
    Dimitrios Avramopoulos
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21231, USA
    Genet Med 9:745-51. 2007
    ..This study is a second stage follow-up focusing on regions that showed positive linkage scores in our previous scan but were not fine-mapped at that time...
  23. doi Phosphorylation status of the NR2B subunit of NMDA receptor regulates its interaction with calcium/calmodulin-dependent protein kinase II
    Rajeevkumar Raveendran
    Rajiv Gandhi Centre for Biotechnology, Thycaud, P O, Thiruvananthapuram 695014, Kerala, India
    J Neurochem 110:92-105. 2009
    ..of post-synaptic Ca(2+)/calmodulin-dependent protein kinase type II (CaMKII) and its translocation to the NR2B subunit of NMDA receptor. The major binding site for CaMKII on NR2B undergoes phosphorylation at Ser1303, in vivo...
  24. doi Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes
    Sabine Endele
    Institute of Human Genetics, University of Erlangen Nuremberg, Erlangen, Germany
    Nat Genet 42:1021-6. 2010
    ..Either GRIN2B or GRIN2A, encoding the NMDA receptor subunits NR2B and NR2A, was found to be disrupted by chromosome translocation breakpoints in individuals with mental retardation ..
  25. ncbi Psychosis and relapse in bipolar disorder are related to GRM3, DAOA, and GRIN2B genotype
    S Dalvie
    Division of Human Genetics, MRC UCT Human Genetics Research Unit, Faculty of Health Sciences, University of Cape Town Medical School, Observatory, Cape Town, South Africa
    Afr J Psychiatry (Johannesbg) 13:297-301. 2010
    ..In this pilot study, we investigated the frequency of SNP variants in these 3 genes within South African population groups, and assessed interactions between genes and phenotypes of BD disease severity...
  26. doi Genetic variants of the NMDA receptor influence cortical excitability and plasticity in humans
    Francesco Mori
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    J Neurophysiol 106:1637-43. 2011
    ..healthy subjects carrying specific allelic variants of the NR1 subunit gene (GRIN1 rs4880213 and rs6293) or of the NR2B subunit gene (GRIN2B rs7301328, rs3764028, and rs1805247)...
  27. pmc Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat
    A H Shin
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Br J Pharmacol 166:1002-17. 2012
    ..Subunit selective NMDA receptor antagonists may differentially modulate survival relative to synaptic changes...
  28. pmc Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia
    J Tarabeux
    Center of Excellence in Neuroscience of Université de Montréal, Centre de recherche du Centre Hospitalier de l Universite de Montreal, and Department of Medicine, University of Montreal, Montreal, QC, Canada
    Transl Psychiatry 1:e55. 2011
    ..Functional compensation could occur to counteract the loss of one allele in GRIN2C and GRIN3 family genes, whereas GRIN1, GRIN2A, GRIN2B and GRIN2D appear instrumental to normal brain development and function...
  29. pmc Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders
    Brian J O'Roak
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA
    Science 338:1619-22. 2012
    ..Our data support associations between specific genes and reciprocal subphenotypes (CHD8-macrocephaly and DYRK1A-microcephaly) and replicate the importance of a β-catenin-chromatin-remodeling network to ASD etiology...
  30. pmc Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures
    Angela H Shin
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Mol Cell Neurosci 54:22-9. 2013
    ..We previously found that ifenprodil, an NR2B subunit-selective NMDA receptor antagonist, induced recovery of postsynaptic densities...
  31. ncbi Heteromeric NMDA receptors: molecular and functional distinction of subtypes
    H Monyer
    Center for Molecular Biology, University of Heidelberg, Germany
    Science 256:1217-21. 1992
    ..cloning identified three complementary DNA species of rat brain, encoding NMDA receptor subunits NMDAR2A (NR2A), NR2B, and NR2C, which are 55 to 70% identical in sequence...
  32. ncbi mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit
    A M Schito
    Institute of Biology and Genetics, University of Genoa, Italy
    Neurosci Lett 239:49-53. 1997
    The expression of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B/epsilon2 (GRIN2B) in the human adult brain was assayed by in situ hybridisation, by using a specific cRNA probe. The full length GRIN2B cDNA was cloned and sequenced...
  33. ncbi Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor
    N M Williams
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Mol Psychiatry 7:508-14. 2002
    ..2). These SNPs will therefore be suitable for studying neuropsychiatric phenotypes that are putatively related to NMDA dysfunction. Pooled analysis provided no support for association between any of the GRIN genes and schizophrenia...
  34. ncbi An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray
    Shengying Qin
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai 230030, PR China
    Eur J Hum Genet 13:807-14. 2005
    ..in the Chinese population, we examined 16 reported SNPs across the NMDA receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B), five of which were identified in the Chinese population...
  35. doi Association analysis of GRIN1 and GRIN2B polymorphisms and Parkinson's disease in a hospital-based case-control study
    Shey Lin Wu
    Department of Neurology, Chang Hua Christian Hospital, Chang Hua, Taiwan
    Neurosci Lett 478:61-5. 2010
    ..78, 95%CI=0.59-1.02, P(trend)=0.073). Our results suggest that polymorphisms in the GRIN1 and GRIN2B genes may serve as potential biomarkers for a reduced risk of PD among the Chinese population in Taiwan...
  36. doi Positive association between GRIN2B gene and bipolar disorder in the Chinese Han Population
    Qian Zhao
    Bio X Center and affiliated Changning Mental Health Center, Shanghai Jiao Tong, University, PR China
    Psychiatry Res 185:290-2. 2011
    ..Rs1805247 and the haplotype consisting of rs1805502 and rs1805247 were significantly associated, suggesting GRIN2B as having a role in the etiology of bipolar disorder...
  37. doi Association between NMDA receptor subunit 2b gene polymorphism and Alzheimer's disease in Chinese Han population in Shanghai
    Chao Chen
    Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
    Neurosci Bull 26:395-400. 2010
    ..The NMDA receptor subunit 2b (NR2B) has attracted more attention due to its characteristic distribution and selective reduction in AD brain...
  38. doi Differential genetic susceptibility in diphasic and peak-dose dyskinesias in Parkinson's disease
    Jee Young Lee
    Department of Neurology, Seoul National University Boramae Hospital, Seoul, Korea
    Mov Disord 26:73-9. 2011
    ..There may be a genetic susceptibility in the development of DDSK in PD patients on chronic levodopa therapy, and its underlying pathophysiological mechanism might be distinct from that of PDSK...
  39. ncbi Striatal neurons but not nigral dopaminergic neurons in neonatal primary cell culture express endogenous functional N-methyl-D-aspartate receptors
    P W Lui
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China
    Brain Res Mol Brain Res 120:9-21. 2003
    ..In striatal neurons, NR1, NR2A and NR2B mRNAs and immunoreactivity, and NR2D mRNA were found and the maximal levels of NR1 mRNA and immunoreactivity ..
  40. ncbi Role of N-methyl-D-aspartate receptors in gastric mucosal blood flow induced by histamine
    Li Hsueh Tsai
    Department of Physiology, School of Medicine, Taipei Medical University, Taipei, Taiwan
    J Neurosci Res 77:730-8. 2004
    ..inhibit histamine-stimulated GMBF and to examine the expression patterns of NMDA receptor subunits NR1, NR2A, and NR2B in rat stomach. Laser Doppler flowmetry was used to measure gastric blood flow in anesthetized rats...
  41. doi Long-term potentiation in the nucleus accumbens requires both NR2A- and NR2B-containing N-methyl-D-aspartate receptors
    Sietske M Schotanus
    The Karolinska Institute, Department of Physiology and Pharmacology, Section of Molecular Neurophysiology, Stockholm, Sweden
    Eur J Neurosci 27:1957-64. 2008
    ..However, the contribution of NR2B in the induction of LTP is not always clearly established...
  42. ncbi Use of trifluoroperazine isolates a [(3)H]Ifenprodil binding site in rat brain membranes with the pharmacology of the voltage-independent ifenprodil site on N-methyl-D-aspartate receptors containing NR2B subunits
    L L Coughenour
    Department of Neuroscience Therapeutics, Pfizer Global Research and Development, Ann Arbor Laboratories, Ann Arbor, Michigan 48105, USA
    J Pharmacol Exp Ther 296:150-9. 2001
    ..binding to a single high affinity state with the pharmacology of N-methyl-D-aspartate (NMDA) receptors containing NR2B subunits...
  43. doi 3-mercaptopropionic acid-induced seizures decrease NR2B expression in Purkinje cells: cyclopentyladenosine effect
    E Girardi
    Instituto de Biología Celular y Neurociencia, Facultad de Medicina, Universidad de Buenos Aires and Consejo Nacional de Investigaciones Científicas y Técnicas CONICET, Paraguay 2155, Buenos Aires, Argentina
    Cell Mol Neurobiol 30:985-90. 2010
    ..In mature Purkinje cells, the combination of NR1 with NR2B subunits forms functional NMDARs; NR2B subunit may be altered in exocitotoxic events...
  44. ncbi Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors
    S Vicini
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Neurophysiol 79:555-66. 1998
    ..outside-out membrane patches excised from cells expressing recombinant NR1 subunits in combination with the NR2A, NR2B, NR2C, or NR2D NMDA receptor subunits...
  45. ncbi Selective subunit antagonists suggest an inhibitory relationship between NR2B and NR2A-subunit containing N-methyl-D: -aspartate receptors in hippocampal slices
    Andrew P Mallon
    Institute of Biomedical and Life Sciences, Division of Neuroscience and Biomedical Systems, West Medical Building, University of Glasgow, Glasgow
    Exp Brain Res 162:374-83. 2005
    ..Here, we have examined the effects of selective antagonists of NR2A and NR2B subunits (NVP-AAM07 and Ro25-6981 respectively) on the effects of NMDA in the CA1 field of rat hippocampal slices...
  46. pmc alpha-Isoform of calcium-calmodulin-dependent protein kinase II and postsynaptic density protein 95 differentially regulate synaptic expression of NR2A- and NR2B-containing N-methyl-d-aspartate receptors in hippocampus
    C S Park
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 151:43-55. 2008
    ..be enhanced, we found a subtle, yet preferential displacement of synaptic N-methyl-d-aspartate receptor subunit 2B (NR2B) subunits in lateral regions of the synapse without affecting changes in the localization of N-methyl-d-aspartate ..
  47. doi The pore region of N-methyl-D-aspartate receptors differentially influences stimulation and block by spermine
    Lihua Jin
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    J Pharmacol Exp Ther 327:68-77. 2008
    The transmembrane and pore-forming regions of N-methyl-D-aspartate receptors containing the NR1 and NR2B subunits were studied by measuring the effects of various NR1 and NR2B mutants on stimulation and block by spermine...
  48. doi Differential roles of NMDA Receptor Subtypes NR2A and NR2B in dendritic branch development and requirement of RasGRF1
    Fernando J Sepulveda
    Dept of Physiopathology, Faculty of Biological Sciences, Univ of Concepción, Concepcion, Chile
    J Neurophysiol 103:1758-70. 2010
    ..However, because NMDARs are abundantly present as tri-heteromers (e.g., NR1/NR2A/NR2B) during development, the precise role of the individual subunits NR2A and NR2B in these processes has not been ..
  49. doi [Expression of NR2B in the spinal dorsal horn and dorsal root ganglia in mice with bone cancer pain]
    Rui Han
    Department of Anesthesiology, Third Xiangya Hospital, Central South University, Changsha, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 35:976-82. 2010
    ..of ethology and the immunohistochemistry results of the 2B Subunits of N-methyl-D-aspartate receptors (NR2B) in the spinal cord dorsal horn and dorsal root ganglia (DRG) in mice with bone cancer pain and their correlation, ..
  50. ncbi NMDA receptor subunit gene expression in the rat brain: a quantitative analysis of endogenous mRNA levels of NR1Com, NR2A, NR2B, NR2C, NR2D and NR3A
    D J Goebel
    Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, 540 E Canfield, Detroit, MI 48201, USA
    Brain Res Mol Brain Res 69:164-70. 1999
    ..Pharmacological properties of recombinant human N-methyl-d-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fiberblast cells, Mol. Pharmacol...
  51. pmc In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death
    M A Martel
    Centre for Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    Neuroscience 158:334-43. 2009
    It has been suggested that NR2B-containing N-methyl-d-aspartate (NMDA) receptors have a selective tendency to promote pro-death signaling and synaptic depression, compared with the survival promoting, synapse potentiating properties of ..
  52. ncbi Deletion of the C-terminal domain of the NR2B subunit alters channel properties and synaptic targeting of N-methyl-D-aspartate receptors in nascent neocortical synapses
    Ralf Mohrmann
    Lehrstuhl fur Zellphysiologie, Ruhr Universitat Bochum, Bochum, Germany
    J Neurosci Res 68:265-75. 2002
    ..To investigate the involvement of the C-terminal domain of the NR2B subunit in regulating channel properties and synaptic localization, we analyzed gene-targeted mice expressing C-..
  53. ncbi Structural characterization of the intermolecular interactions of synapse-associated protein-97 with the NR2B subunit of N-methyl-D-aspartate receptors
    Lei Wang
    Department of Physics, Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 280:26992-6. 2005
    ..The molecular scaffold/receptor interaction is mediated by the association of the C terminus of the NR2B subunit of the N-methyl-D-aspartate receptor with the PDZ domains of SAP97...
  54. doi Structural basis of NR2B-selective antagonist recognition by N-methyl-D-aspartate receptors
    Laetitia Mony
    Laboratoire de Neurobiologie, Centre National de Recherche Scientifique CNRS Unité Mixte de Recherche 8544, Ecole Normale Superieure, Paris, France
    Mol Pharmacol 75:60-74. 2009
    ..are ifenprodil and derivatives, compounds that act as noncompetitive inhibitors selective for NMDARs containing the NR2B subunit...
  55. ncbi Development of NR1, NR2A and NR2B mRNA in NR1 immunoreactive cells of rat visual cortex
    Z Cao
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Brain Res 868:296-305. 2000
    ..between the sensitive period for monocular deprivation and the expression of rat NMDAR subunits, NR2A and NR2B. In the rat the sensitive period ends sometime after postnatal day 50 (P50)...
  56. ncbi Different trends in modulation of NMDAR1 and NMDAR2B gene expression in cultured cortical and hippocampal neurons after lead exposure
    W K Lau
    Department of Biology and Institute for Natural Resources and Environmental Management, Hong Kong Baptist University, Hong Kong, Kowloon Tong, PR China
    Brain Res 932:10-24. 2002
    ..In order to investigate the effects of Pb(2+) on the gene expression of NR1 and NR2B subunits in neurons, primary cell cultures of rat cortical and hippocampal neurons were employed...
  57. pmc Inhibition of NR2B phosphorylation restores alterations in NMDA receptor expression and improves functional recovery following traumatic brain injury in mice
    Johanna Schumann
    Department of Pharmacology, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel
    J Neurotrauma 25:945-57. 2008
    ..In the hippocampus, the expression of NR1, NR2A, and NR2B subunits as well as the GluR1 subunit of the AMPA receptor (AMPAR) were increased, while in the cortex at the ..
  58. pmc Fear memory impairing effects of systemic treatment with the NMDA NR2B subunit antagonist, Ro 25-6981, in mice: attenuation with ageing
    Poonam Mathur
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, NIH, Rockville, MD 20852 9411, USA
    Pharmacol Biochem Behav 91:453-60. 2009
    ..We characterized pre-conditioning systemic treatment of the NR2B subunit-selective antagonist Ro 25-6981 for effects on multi-trial, one-trial and low-shock Pavlovian fear ..
  59. doi Forelimb dyskinesia mediated by high-frequency stimulation of the subthalamic nucleus is linked to rapid activation of the NR2B subunit of N-methyl-D-aspartate receptors
    Adrien Quintana
    Institut National de la Sante et de la Recherche Medicale, Unité 836 INSERM U386, Universite Joseph Fourier, Grenoble, France
    Eur J Neurosci 32:423-34. 2010
    ..in glutamatergic neurotransmission as previously reported for L-DOPA-induced dyskinesias, focusing on the role of NR2B-containing N-methyl-D-aspartate receptors (NR2B/NMDARs)...
  60. ncbi [Anti-nMDA receptor encephalitis--clinical manifestations and pathophysiology]
    Takahiro Iizuka
    Department of Neurology, School of Medicine, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa, 228 8555, Japan
    Brain Nerve 60:1047-60. 2008
    ..Two years later, they identified conformal extracellular epitopes present in the NR1/NR2B heteromers of NMDAR, which are expressed in the hippocampus/forebrain...
  61. ncbi Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia
    Bichoy H Gabra
    Department of Pharmacology and Toxicology, Virginia Commonwealth University Medical Center, P O Box 980613, Richmond, VA 23298 0613
    J Pharmacol Exp Ther 322:186-94. 2007
    ..antagonist at the glycine-binding site of the NMDAR), ifenprodil and Ro 25-6981 (selective antagonists of the NR2B subunit of the NMDAR), bisindolylmaleimide I and Go-7874 [12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-..
  62. doi Chronic unpredictable stress before pregnancy reduce the expression of brain-derived neurotrophic factor and N-methyl-D-aspartate receptor in hippocampus of offspring rats associated with impairment of memory
    Yuejun Huang
    The Department of Pediatrics, The Second Affiliated Hospital of Medical College of Shantou University, North Dongxia Road, 515041, Shantou, Guangdong Province, China
    Neurochem Res 35:1038-49. 2010
    ..well as the expression of brain-derived neurotrophic factor (BDNF), N-methyl-D-aspartate (NMDA) 2A (NR2A) and 2B (NR2B) receptors in the hippocampus of the offspring rats when they were 2 months postnatally...
  63. ncbi Localization of N-methyl-D-aspartate NR2B subunits on primary sensory neurons that give rise to small-caliber sciatic nerve fibers in rats
    Q P Ma
    Department of Pharmacology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, CM20 2QR, Harlow, UK
    Neuroscience 101:699-707. 2000
    ..and retrograde tracing techniques to investigate the relationship between the N-methyl-D-aspartate receptor NR2B subunits and small-diameter primary afferent dorsal root ganglion neurons that give rise to the sciatic nerve ..
  64. pmc NR2B subunit of the NMDA receptor in the basolateral amygdala is necessary for the acquisition of conditioned defeat in Syrian hamsters
    Diane E Day
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    Behav Brain Res 217:55-9. 2011
    ..heteromeric receptor complex, making it difficult to distinguish the relative contributions of either the NR2A or NR2B receptor subtypes on the acquisition of CD...
  65. ncbi Transient down-regulation of NMDA receptor subunit gene expression in the rat retina following NMDA-induced neurotoxicity is attenuated in the presence of the non-competitive NMDA receptor antagonist MK-801
    D J Goebel
    Department of Anatomy and Cell Biology, Wayne State University, School of Medicine, Canfield, Detroit, MI 48201, USA
    Exp Eye Res 72:547-58. 2001
    ..Following NMDA insult, the mRNA levels for NR1(com ), NR2A, NR2B and, to a lesser extent, the NR2C subunit were substantially reduced within 24 hr post-treatment (PT), and remained ..
  66. doi Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligation
    Shan Jing Geng
    Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xue Yuan Road, Beijing 100191, PR China
    Exp Neurol 222:256-66. 2010
    ..cord BDNF contributes to the development and maintenance of neuropathic pain by activation of the dorsal horn NR2B-containing NMDA (NMDA-2B) receptors, this study was designed to investigate if alterations in BDNF and its TrkB ..
  67. ncbi Contribution of NR2B subunits to synaptic transmission in amygdaloid interneurons
    Csaba Szinyei
    Institute of Physiology, Medical School, Otto von Guericke University, 39120 Magdeburg, Germany
    J Neurosci 23:2549-56. 2003
    ..time course, with both components being significantly reduced by ifenprodil (10 microm), an antagonist of the NR2B subunit of NMDA receptors...
  68. ncbi Differential modulation of Ca2+/calmodulin-dependent protein kinase II activity by regulated interactions with N-methyl-D-aspartate receptor NR2B subunits and alpha-actinin
    A J Robison
    Department of Molecular Physiology and Biophysics, Center for Molecular Neurosciences and The Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
    J Biol Chem 280:39316-23. 2005
    ..The NR2B subunit of N-methyl-d-aspartate (NMDA)-type glutamate receptor, densin-180, and alpha-actinin bind comparable, ..
  69. pmc Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors
    T R Butler
    Department of Psychology, University of Kentucky, Lexington, KY 40536 0509, USA
    Neuroscience 165:525-34. 2010
    ..of mature neuron density (NeuN); microtubule associated protein-2(a,b) density (MAP-2); and NMDA receptor NR1 and NR2B subunit density in the primary cell layers of the dentate gyrus (DG), CA3, and CA1 regions, was conducted...
  70. doi In vivo neurochemical effects of the NR2B selective NMDA receptor antagonist CR 3394 in 6-hydroxydopamine lesioned rats
    Sophie Sarre
    Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, B1090 Brussels, Belgium
    Eur J Pharmacol 584:297-305. 2008
    ..N-[2-(3,5-dimethyl-1-adamantyl)ethyl]acetamidine, an adamantane derivative with preferential selectivity for the NR2B subunit of the NMDA receptor, has dopamine releasing properties in vivo...
  71. ncbi Osmotic activation of the hypothalamo-neurohypophysial system reversibly downregulates the NMDA receptor subunit, NR2B, in the supraoptic nucleus of the hypothalamus
    M C Currás-Collazo
    Department of Neuroscience, University of California at Riverside, Riverside, CA 92521, USA
    Brain Res Mol Brain Res 70:187-96. 1999
    ..we examined the effects of osmotic stimulation on the protein expression of the NMDA receptor subunits, NR1 and NR2B, important in binding glycine and glutamate, respectively...
  72. ncbi Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia
    Wei Guo
    Department of Biomedical Sciences, Dental School and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 24:9161-73. 2004
    Hindpaw inflammation induces tyrosine phosphorylation (tyr-P) of the NMDA receptor (NMDAR) 2B (NR2B) subunit in the rat spinal dorsal horn that is closely related to the initiation and development of hyperalgesia...
  73. pmc The site specific demethylation in the 5'-regulatory area of NMDA receptor 2B subunit gene associated with CIE-induced up-regulation of transcription
    Mei Qiang
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 5:e8798. 2010
    ..We recently reported that NMDA receptor 2B (NR2B) gene expression was persistently up-regulated following chronic intermittent ethanol (CIE) treatment...
  74. pmc Molecular determinants of NMDA receptor function in GABAergic neurones of rat forebrain
    T Plant
    I Physiologisches Institut, Universitat des Saarlandes, Homburg, Germany
    J Physiol 499:47-63. 1997
    ..When tested for NR2A-C, all but one neurone were shown to express mRNA for NR2B. The NR2B subunit mRNA was usually detected together with NR2A or NR2C...
  75. pmc Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats
    Jian Yang
    Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, United Kingdom
    J Neurosci 26:406-10. 2006
    ..R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid] and NR2B [(alphaR, betaS)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidinepropanol hydrochloride (Ro 25-..
  76. pmc N-methyl-D-aspartate receptor subunit phenotypes of vagal afferent neurons in nodose ganglia of the rat
    Krzysztof Czaja
    Programs in Neuroscience and Department of Veterinary, Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Washington State University, Pullman, 99163 6520, USA
    J Comp Neurol 496:877-85. 2006
    ..Although NMDA receptor subunits (NR1, NR2B, NR2C, and NR2D) have been linked to distinct neuronal populations in the brain, the NMDA receptor subunit ..
  77. ncbi Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1 subunits of the NMDA and AMPA receptors
    Xiuwu Zhang
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 32:377-87. 2007
    ..changes were associated with parallel alterations in expression levels and/or phosphorylation changes in the NR2B and GluR1 subunits of the respective NMDA and AMPA receptors...
  78. ncbi Interleukin-1 beta released by gp120 drives neural death through tyrosine phosphorylation and trafficking of NMDA receptors
    Barbara Viviani
    Laboratory of Toxicology and Center of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Biol Chem 281:30212-22. 2006
    ..Increased phosphorylation of NR2B Tyr-1472 was observed after 24 h of exposure of neurons to 600 pm gp120...
  79. doi Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices
    Gerhard Rammes
    Dept of Anesthesiology, Technische Universitat Munchen, D 81675 Munich, Germany
    Neuropharmacology 60:982-90. 2011
    ..NMDA receptors containing the NR2B subunit have been proposed to play a particularly important role in excitotoxicity, functioning as extracellular "..
  80. ncbi Pharmacological heterogeneity of NMDA receptors: characterization of NR1a/NR2D heteromers expressed in Xenopus oocytes
    A L Buller
    Department of Pharmacology, University of Nebraska Medical Center, Omaha 68198 6260, USA
    Eur J Pharmacol 320:87-94. 1997
    ..NMDA receptors expressed in Xenopus oocytes was examined and compared to the pharmacology of NR1a/NR2A, NR1a/NR2B and NR1a/NR2C heteromers...
  81. ncbi Developmental changes in localization of NMDA receptor subunits in primary cultures of cortical neurons
    J H Li
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    Eur J Neurosci 10:1704-15. 1998
    ..using antibodies against distinct N-methyl-D-aspartic acid (NMDA) receptor subunits, illustrated that the NR2A and NR2B subunit proteins have developmental profiles in cultured cortical neurons similar to those seen in vivo...
  82. ncbi Virally mediated knock-down of NR2 subunits ipsilateral to the deprived eye blocks ocular dominance plasticity
    Zhiping Cao
    Portland VA Medical Center, PO Box 1034 P3ANES, Portland, OR 97239, USA
    Exp Brain Res 177:64-77. 2007
    NMDA receptors (NMDARs) are important in developmental plasticity in the visual cortex. The NR2A and NR2B subunits of this receptor develop with different time courses, suggesting that they play different roles in plasticity...
  83. pmc Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma
    Josep Dalmau
    Department of Neurology, Division of Neuro Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Neurol 61:25-36. 2007
    ..To report the autoantigens of a new category of treatment-responsive paraneoplastic encephalitis...
  84. ncbi Effects of an anabolic-androgenic steroid on the regulation of the NMDA receptor NR1, NR2A and NR2B subunit mRNAs in brain regions of the male rat
    P Le Greves
    Department of Pharmaceutical Biosciences, Uppsala University
    Neurosci Lett 226:61-4. 1997
    The expression of the N-methyl-D-aspartate (NMDA) receptor subunits NR1, NR2A and NR2B mRNAs was examined in discrete areas of the male rat brain (including hippocampus, hypothalamus, nucleus accumbens and cortex) following 14 days daily ..
  85. ncbi Odorant deprivation reversibly modulates transsynaptic changes in the NR2B-mediated CREB pathway in mouse piriform cortex
    Hyun H Kim
    Department of Anatomy and Neurobiology, University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 26:9548-59. 2006
    ..Permanent zinc sulfate lesion of the olfactory epithelium resulted in a selective loss of the NMDA receptor NR2B protein and mRNA expression in pyramidal cells in layer IIb of PC after 2-7 d...
  86. ncbi Ontogeny of ionotropic glutamate receptor expression in human fetal brain
    L M Ritter
    Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Brain Res Dev Brain Res 127:123-33. 2001
    ..AMPA, and kainate receptor subunit transcripts were present during development, with a greater abundance of NR1, NR2B, NR2D, GluR7, and KA1 mRNA at most gestational ages...
  87. ncbi Site-selective N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate antagonists produce distinct effects in rats performing complex discriminations
    Catherine B Willmore
    Department of Pharmaceutical Sciences, University of Maryland, Baltimore, 21201, USA
    Neurobiol Learn Mem 78:347-64. 2002
    ..The NMDA receptor has numerous modulatory centers, including the glycine binding site, NR2B protein specific binding site, and an intrachannel (PCP) binding site...
  88. ncbi Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket
    Pari Malherbe
    Pharma Division, Discovery Research CNS, F Hoffmann La Roche Ltd, CH 4070 Basel, Switzerland
    J Pharmacol Exp Ther 307:897-905. 2003
    ..propanol (RO 25-6981), is a high-affinity and selective blocker of NMDA receptors containing the NR2B subunit...
  89. ncbi Laminar distribution of NMDA receptor subunit (NR1, NR2A, NR2B) expression during the critical period in cat visual cortex
    George D Mower
    Department of Anatomical Sciences and Neurobiology, Health Sciences Center, University of Louisville School of Medicine, 500 South Preston St, A Bldg, Rm 902, Louisville, KY 40202, USA
    Brain Res Mol Brain Res 119:19-27. 2003
    ..to determine developmental changes in the laminar distribution of the three major cortical NMDA subunits (NR2A, NR2B, NR1) during the critical period in cat visual cortex...
  90. ncbi Effects of dietary long chain PUFAs on hippocampal lipid peroxidation and NMDA receptor subunits A and B concentration in streptozotocin-diabetic rats
    Namik Delibas
    Suleyman Demirel University, Faculty of Medicine, Department of Biochemistry and Physiology, Isparta, Turkey
    Int J Neurosci 114:1353-64. 2004
    ..LC-PUFAs administration significantly reduced MDA levels in diabetic rats. NR2A and NR2B protein concentrations were significantly decreased by about 30% in diabetic rats...
  91. ncbi The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health CIMH, J5, 68159 Mannheim, Germany
    Neuropharmacology 48:822-9. 2005
    ..324, the NR2B subunit selective antagonist ifenprodil, which acts at the polyamine binding site, the NMDAR channel blocker ..
  92. ncbi Upregulation of mRNAs coding for AMPA and NMDA receptor subunits and metabotropic glutamate receptors in the dorsal horn of the spinal cord in a rat model of diabetes mellitus
    Masahiko Tomiyama
    Third Department of Medicine, Hirosaki University School of Medicine, Zaifu cho 5, Hirosaki 036 8216, Japan
    Brain Res Mol Brain Res 136:275-81. 2005
    ..The hybridization signals for NR2A mRNA and NR2B mRNA were significantly elevated in the deep layer of the dorsal horn of diabetic rats...
  93. ncbi Effects of SDF-1alpha and gp120IIIB on apoptotic pathways in SK-N-SH neuroblastoma cells
    Thomas Geeraerts
    Laboratoire Immunologie Antivirale Systémique et Cérébrale, INSERM EMI 0109, Faculte de Medecine Paris Sud, 63 rue Gabriel Peri, 94 276 Le Kremlin Bicêtre, France
    Neurosci Lett 399:115-20. 2006
    ..SDF-1alpha enhanced NMDA activity indirectly via Src phosphorylation, whereas gp120(IIIB) probably activated the NMDA receptor directly and phosphorylated JNK...
  94. pmc EphrinB2 induces tyrosine phosphorylation of NR2B via Src-family kinases during inflammatory hyperalgesia
    S Slack
    Wolfson Centre for Age Related Diseases, Hodgkin Building, Wolfson Wing, King s College London, London SE1 1UL, UK
    Neuroscience 156:175-83. 2008
    ..In particular, EphB receptor activation would induce phosphorylation of the NR2B subunit of the NMDA receptor by a Src family non-receptor tyrosine kinase...
  95. doi NMDA NR2 receptors participate in CCK-induced reduction of food intake and hindbrain neuronal activation
    D B Guard
    Physiology IDGP, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Brain Res 1266:37-44. 2009
    ..NMDAR are heteromeric complexes composed of NR1, NR2 and NR3 subunits. Competitive NR2B antagonists potently increase feeding when injected into the hindbrain...
  96. pmc Impaired glial glutamate uptake induces extrasynaptic glutamate spillover in the spinal sensory synapses of neuropathic rats
    Hui Nie
    Department of Pain Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Neurophysiol 103:2570-80. 2010
    ..The enhanced NMDA EPSCs were accompanied by an increased proportion of NR2B receptor activation...
  97. pmc Activation of NMDA receptors leads to phosphorylation of TRPV1 S800 by protein kinase C and A-Kinase anchoring protein 150 in rat trigeminal ganglia
    Jongseok Lee
    University of Maryland School of Dentistry, Department of Neural and Pain Sciences, Program in Neuroscience, 650 W Baltimore Street, Baltimore, MD 21201, United States
    Biochem Biophys Res Commun 424:358-63. 2012
    ..with TRPV1 and demonstrated that it also co-immunoprecipitated with NMDA receptor subunits (NR1 and NR2B) in TG...
  98. doi Expression of NR2B in different brain regions and effect of NR2B antagonism on learning deficits after experimental subarachnoid hemorrhage
    G Chen
    Department of Neurosurgery and Neurology, The First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
    Neuroscience 231:136-44. 2013
    ..The mechanisms are not known. NR2B, one of the subunits of N-methyl-d-aspartate (NMDA) receptors, has been proved to be an important factor for ..
  99. pmc VEGF activates NR2B phosphorylation through Dab1 pathway
    Kristy R Howell
    Department of Psychiatry and Health Behavior, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA
    Neurosci Lett 552:30-4. 2013
    ..1 (Dab1), a downstream signaling molecule of reelin pathway mediates VEGF-induced regulation of NMDAR subunit NR2B. Furthermore, VEGF treatment led to the association of VEGF receptor-2 (Flk1) and reelin receptor (apolipoprotein E ..
  100. ncbi Role of AP-1 in ethanol-induced N-methyl-D-aspartate receptor 2B subunit gene up-regulation in mouse cortical neurons
    Mei Qiang
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 95:1332-41. 2005
    ..study, we investigated the DNA-protein binding activities and promoter activity in the N-methyl-D-aspartate R2B (NR2B) gene AP-1 site in normal and ethanol-treated cultured neurons...
  101. ncbi NMDA receptor subtypes at autaptic synapses of cerebellar granule neurons
    Congyi Lu
    Department of Physiology and Biophysics, BSB225, Georgetown University School of Medicine, 3900 Reservoir Rd, Washington, DC 20007, USA
    J Neurophysiol 96:2282-94. 2006
    ..The NR2B-selective antagonists Conantokin G and CP101,606 differed in their blocking actions with development, suggesting ..

Research Grants64

  1. Roles for gliotransmisssion in seizure-related disorders
    Philip G Haydon; Fiscal Year: 2010
    ..follows status epilepticus, and III: Ca2+-dependent gliotransmission induces neuronal death by the activation of NR2B-containing NMDA receptors...
  2. MOLECULAR STUDIES OF BRAIN NMDA RECEPTORS
    R Suzanne Zukin; Fiscal Year: 2009
    ..extrasynaptic (NR1/NR2B) NMDARs in hippocampal neurons...
  3. Immunity to brain Ma proteins: A remote effect of cancer
    Josep Dalmau; Fiscal Year: 2007
    ..these patients had antibodies to cell surface antigens (highly enriched in hippocampus), which we identified as the NR2B (and at a lesser degree NR2A) subunits of the NMDA receptor...
  4. Steroids-Functional Modulators of Amino Acid Receptors
    DAVID FARB; Fiscal Year: 2007
    ..NR2A or NR2B confers PS potentiation, whereas NR2C or NR2D confers PS inhibition...
  5. Stephen Traynelis; Fiscal Year: 2016
    ..0 (125 nM H+) or 7.4 (50 nM H+) for recombinant NRI/NR2A and NRI/NR2B receptors...
  6. Shinghua Ding; Fiscal Year: 2014
    ..Specifically, we will determine whether astrocytes stimulate the NR2B- containing NMDAR (NR2B-NMDAR)-mediated neuronal excitation after ischemia...
  7. Role of CREST in cortical development and plasticity
    Massimo Scanziani; Fiscal Year: 2013
    ..down-regulation of GluR2 expression;(ii) To examine the role CREST in activity-dependent regulation of NR2B expression;(iii) To examine the role of CREST in regulating the AMPA: NMDA ratio in vivo and to determine if CREST ..
  8. Xin Yun Lu; Fiscal Year: 2016
    ..reuptake inhibitor (SSRI) treatments but highly responsive to the glutamate receptor NMDA- NR2B (also termed GluN2B) antagonist...
  9. ETHANOL, NEUROSTEROIDS &HIPPOCAMPAL PLASTICITY
    Charles F Zorumski; Fiscal Year: 2013
    ..inhibits a specific subtype of synaptic N-methyl-D-aspartate receptor (NMDAR) that is also inhibited by the NR1/NR2B antagonist, ifenprodil. Block of LTD by ethanol correlates with the block of these synaptic NMDARs...
  10. Dopamine's Role in the Rapid Estradiol Enhancement of Excitatory Synapses
    CAROLINE COFER SMITH HAMILTON; Fiscal Year: 2013
    ..of long-term potentiation (LTP), a cellular substrate of memory acquisition, by enhancing current mediated by NR2B-containing-NMDARs...
  11. Antibodies to NR2 in SLE
    Betty Diamond; Fiscal Year: 2011
    ..anti-DNA antibodies cross-reacts with a 5 amino acid sequence present in the extracellular domain of the NR2A and NR2B subunits of the N-methyl-D-aspartate receptor (NMDAR)...
  12. Roger J Colbran; Fiscal Year: 2015
    ..of CaMKII, mutation of CaMKII autophosphorylation sites, or blocking CaMKII binding to NMDA receptor (NMDAR) GluN2B (formerly NR2B) subunits disrupts normal LTP at hippocampal glutamatergic synapses...
  13. Adenosine Receptors and Ethanol Withdrawal
    TRACY RENEE BUTLER; Fiscal Year: 2010
    ..of EtOH, immunohistochemistry will be employed for the adenosine A1 and A2A receptor subtypes and the NMDA NR1 and NR2B subunits to quantify receptor density in the primary cell layers of the dentate gyrus, and the CA3 and CAI regions ..
  14. Jun Wang; Fiscal Year: 2016
    ..exposure and withdrawal causes a long-lasting increase in the activity of the NMDA receptors (NMDARs) that contain NR2B subunits (NR2B- NMDARs) in the dorsomedial striatum (DMS), and that inhibition of NR2B-NMDARs specifically within ..
  15. Katumi Sumikawa; Fiscal Year: 2014
    ..Our study shows that in vivo exposure to nicotine causes the enhancement of NR2B-containing NMDAR-mediated responses via tyrosine phosphorylation, leading to long-lasting long-term potentiation (..
  16. Schahram Akbarian; Fiscal Year: 2014
    ..This resulted in decreased levels of the NMDA receptor subunit Grin2b (NR2B) in prefrontal cortex and hippocampus...
  17. DAPK1 regulation of NMDA receptors in ischemic neuronal death
    NICOLAS GUILLERMO BAZAN; Fiscal Year: 2012
    ..Activation of NR2A and NR2B receptor channels are permeable to Na+ and K+ and also to Ca2+, which triggers multiple intracellular catabolic ..
  18. James A McRoberts; Fiscal Year: 2016
    ..the following hypotheses: 1) To be functional, NMDARs in primary afferents require Tyr-phosphorylation of their NR2B subunit, which is determined by the balance of activities of SFKs and protein tyrosine phosphatases, 2) SFK ..
  19. Lennart Mucke; Fiscal Year: 2016
    ..cultures from WT mice, exposure to human A-beta oligomers increased DSBs, and this effect was prevented by blocking NR2B-containing NMDA-type glutamate receptors...
  20. Grace E Stutzmann; Fiscal Year: 2014
    ..2) Investigate silent synapse formation and the contribution of NR2B-containing NMDARs to silent synapses during the incubation of cocaine craving...
  21. Helen M Bramlett; Fiscal Year: 2014
    ..in local hippocampal circuit activity after trauma due to an imbalance in inhibitory (GABAA) and excitatory (NR2B) receptor function will be assessed...
  22. Hiroyasu Furukawa; Fiscal Year: 2016
    ..by the binding of allosteric modulators, including Zn2+, ifenprodil, proton, and polyamines, to the NR1 and NR2B ATDs...
  23. Patient-Derived Stem Cells for Phosphoproteomic Profiling Neuropsychopathology
    Dieter A Wolf; Fiscal Year: 2011
    ..Lithium correlates with reduced phosphorylation of the NMDA receptor subunit NR2B in rat cortical neurons {Hashimoto, 2002 #159}...
  24. Macrophages, NR2B-containing NMDA Receptors and HIV Dementia
    HUANGUI HANK XIONG; Fiscal Year: 2013
    ..composed, in large part, of NR2A-containing NMDARs (NR2ARs), promote cell survival, whereas extrasynaptic NMDARs, NR2B-containing NMDARs (NR2BRs), induce cell death...
  25. Yan Dong; Fiscal Year: 2016
    ..afferent is initiated by the formation of new presynaptic terminals and new postsynaptic partners enriched in NR2B subunit- containing NMDARs;and ii) is completed by postsynaptic insertion of calcium-permeable AMPA receptors...
  26. James A Bibb; Fiscal Year: 2014
    ..We found that this was due to changes in the levels and surface expression of the NR2B subunit of the NMDA receptor...
  27. Blood Coagulation Protein - Metal Ion - Lipid Interactions
    Francis J Castellino; Fiscal Year: 2013
    ..HEK293 cells and in primary neurons, testing the hypothesis that the downstream neuroprotective effects of NR2B-specific conantokins are achieved by modulation of steps of the the ERK1/2 pathway...
  28. Paco S Herson; Fiscal Year: 2016
    ..activity is induced by autophosphorylation of residue T286 and/or direct binding to NMDAr subunit NR2B at the synapse (which also mediates CaMKII accumulation at the synapse)...
  29. Src Family Kinases - Mediated Ischemic Neonatal Brain Injury
    Xiangning Jiang; Fiscal Year: 2010
    ..We hypothesize that neonatal HI increases tyrosine phosphorylation of NR2A and NR2B mediated by SFKs (hypothesis I) and inhibition of SFKs activity or deletion of Fyn provides cerebral protection ..
  30. Alan Frazer; Fiscal Year: 2014
    ..study is designed to study the role of miRNA in the DNA methylation underlying neuroadaptive up-regulation of NR2B gene during alcohol withdrawal...
  31. EFFECTS ON AB ON SYNAPTIC TRANMISSION AND PLASTICITY
    Paul Greengard; Fiscal Year: 2011
    ..In addition we propose to investigate the role of STEP, dephosphorylation of NR2B and GluR1, and Cdk5-WAVE1 in Ap-induced glutamate receptor endocytosis (Aim II)...
  32. Synaptic Regulation of Neurogenesis in the Dentate Gyrus
    Brian E Derrick; Fiscal Year: 2012
    ..GCs also accelerates their functional development This will be assessed by determining the earliest time point when NR2B NMDAR subunits and Zif268, an IEG protein implicated in synaptic plasticity, can be expressed following afferent-..
  33. OLIVER SCHLUETER; Fiscal Year: 2014
    ..In previous work, we showed that cocaine exposure increases synaptic levels of NR2B-containing NMDA re- ceptors in the NAc...
  34. Ethanol-induced NMDA R1 mRNA Stabilization
    Meena Kumari; Fiscal Year: 2013
    ..exposure up regulates NMDA receptor number/function in vivo and in vitro with a concomitant increase in NR1 and NR2B protein levels...
  35. Estrogen and hippocampal plasticity
    LORI LYNN MCMAHON; Fiscal Year: 2012
    ..that E2 increases the magnitude of LTP by increasing the density of silent synapses which express NMDARs containing NR2B subunits;AIM 2 will test the hypothesis that E2 mediated effects on spine density and synaptic function are not ..
  36. Yan Dong; Fiscal Year: 2016
    ..Our central hypothesis, based on extensive preliminary results, is that increased transmission via NR2B-containing NMDARs constitutes a "false" homeostatic signal that triggers HSMC and subsequent homeostatic ..
  37. Raymond A Swanson; Fiscal Year: 2016
    ..Preliminary studies suggest that key components of this pathway include the NR2B subunit of NMDA-type glutamate receptors, phosphoinositol-3-kinase (PI3K), PTEN, and phospholipase A2...
  38. Developmental and experience-dependent changes in synaptic plasticity
    JACQUELINE DEMARCHENA; Fiscal Year: 2010
    ..synaptic NMDARs undergo a dramatic activity-dependent change in subunit composition, going from being primarily NR2B-type, to increasingly NR2A-type, with maturity...
  39. James A Bibb; Fiscal Year: 2016
    ..We discovered that the protein kinase Cdk5 physically links calpain to the NR2B subunit of NMDARs. Cdk5 is also bound to its activator p35...
  40. Young Bum Kim; Fiscal Year: 2015
    ..of POMC and AGRP neurons regulates phosphorylation and activity of post-synaptic glutamate receptors (NMDA-R(NR1/NR2B)), and that this pathway influences dendrite morphology, and eventually plays a role in energy balance regulation ..
  41. Kalirin-7 is essential in cocaine signaling: focus on nucleus accumbens
    DREW KIRALY; Fiscal Year: 2013
    ..Additionally, we have recently discovered that Kal7KO animals have altered surface trafficking of the NR2B subunit of NMDA receptors...
  42. Terunaga Nakagawa; Fiscal Year: 2014
    ..In particular, we will use EM to study the structure of heterotetrameric NMDA-Rs formed by NR1 and NR2B subunits...
  43. Hippocampal Network Profiles of Memory Aging
    Joe Z Tsien; Fiscal Year: 2010
    ..memory performances? 3) How does the aging process affect those characteristics? 4) What is the role of the NR2B in the regulation of network-level features underling the enhanced memory during ageing? It is conceivable that ..
  44. SALLY ANN FRAUTSCHY; Fiscal Year: 2016
    ..of ptau but act synergistically to reduce cognitive deficits, NFT, tau oligomers and insoluble tau and correct NR2B or PSD-95 receptor complex dysregulation in aged htau mice. 8...
  45. Structural and Catalytic Functions of CaMKII in Neurons
    K Ulrich Bayer; Fiscal Year: 2011
    ..is to test our hypotheses that synaptic translocation requires binding to the NMDA-type glutamate receptor subunit NR2B and is involved in synaptic plasticity, while formation of extrasynaptic clusters is mediated by CaMKII self-..
  46. Molecular Mechanisms of Reconsolidation Boundaries
    Jonathan E Ploski; Fiscal Year: 2013
    ..of reconsolidation updating is caused by a change in the synaptic N-methyl D-aspartate receptor subunit NR2A/NR2B ratio...
  47. Stanley A Thayer; Fiscal Year: 2014
    ..Treatment with ifenprodil, an antagonist selective for NR2B-containing NMDA receptors, induced the recovery of synapses lost following in vitro exposure to the HIV-1 protein ..
  48. James A Bibb; Fiscal Year: 2016
    ..This mechanism involves the modulation of the phosphorylation state of Ser1116 of the NR2B subunit of these receptors. This site is phosphorylated by the neuronal protein kinase, Cdk5...
  49. Modulating plasticity in adult-born neurons of the dentate gyrus
    Mazen A Kheirbek; Fiscal Year: 2012
    ..synaptic plasticity during a critical window of their development, an enhanced plasticity mediated by the NR2B subunit-containing NMDA receptors...
  50. THE ROLE OF GLIOTRANSMISSION IN MEDIATING THE CENTRAL EFFECTS OF ALCOHOL
    Sally McIver; Fiscal Year: 2012
    ..and consumption of alcohol can be mediated by activation of the src family kinases (SFK) and a known substrate, the NR2B subunit of the NMDAR...
  51. Actin Dynamics and Spine Remodeling in Ethanol-Induced Plasticity
    L Judson Chandler; Fiscal Year: 2013
    ..A potential adaptive mechanism we recently identified is the selective targeting of NR2B-containing NMDA receptors to the synapse...
  52. Optimization of small molecule probes
    Stephen F Traynelis; Fiscal Year: 2013
    ..The EC50 value for each compound will be determined at recombinant NR1/NR2A, NR1/NR2B, NR1/NR2C, NR1/NR2D, GluR1 receptors using 14 automated two-electrode voltage-clamp recording systems that can ..
  53. The Roles of NR2A and NR2B in Excitotoxicity
    Kelly A Foster; Fiscal Year: 2010
    ..Initial pharmacological data indicate that specific NMDAR subunits, specifically NR2A and NR2B, may play different roles in excitotoxicity. However, the results thus far are confusing and contradictory...
  54. Danny G Winder; Fiscal Year: 2014
    ..involved in these actions through the use of a new conditional knockout mouse for the NMDA receptor subunit NR2B combined with a viral-directed knockout strategy...
  55. HETEROGENEITY OF SYNAPTIC NMDA RECEPTORS
    Stefano Vicini; Fiscal Year: 2002
    ..The result of this study will reveal how the relative contribution of the NMDA subunit NR1 and NR2B determines the kinetics of NMDA-mediated synaptic currents in developing rat neocortical and cerebellar neurons...
  56. Novel mechanism-based treatments for infantile spasms
    LIBOR VELISEK; Fiscal Year: 2010
    ..3) Prenatal priming accelerates developmental switch in replacing NR2B subunit of the NMDA receptor with the NR2A subunit...
  57. Paul J Lombroso; Fiscal Year: 2014
    ..Over the last cycle, we have discovered that STEP also induces NR1/NR2B and GluR1/GluR2 internalization...
  58. Molecular basis of homocysteine-glutamate receptor mediated neuronal cell death
    Ranjana Poddar; Fiscal Year: 2012
    ..Glutamate-mediated stimulation of NR2A containing NMDA receptor subtypes promotes while stimulation of NR2B containing NMDA receptor subtypes inhibits activation of ERK resulting in transient activation of ERK MAPK...
  59. Claude G Wasterlain; Fiscal Year: 2015
    ..2/ a NMDA receptor antagonist which could be non-specific (dizocilpine or ketamine) or NR2B subunit-preferring (R025-6981 or felbamate), and 3/ an anticonvulsant acting at a non-GABA site such as rapidly ..
  60. Epigenetic mechanisms: CIE-induced NR2B gene up-regulation in alcohol dependence
    Alan Frazer; Fiscal Year: 2011
    ..intermittent ethanol (CIE) exposure produces longer-lasting molecular adaptations including up-regulation of NR2B gene expression and persistence, which is viewed as an important neurobiological basis for the development of ..
  61. Stephen W Scherer; Fiscal Year: 2016
    ..By combining brain imaging and genetics, as we do in this proposal, we can better understand the biology of pediatric OCD and, in turn, develop more effective treatments for this severe form of childhood psychopathology. ..
  62. William G North; Fiscal Year: 2014
    ..the distribution, abundance, and tumor selectivity of expression in pancreatic cancer of both NMDAR1 and NMDAR2B receptors . Treatment with antibodies will be compared with those using ubiquitous IgG...