NQO2

Summary

Gene Symbol: NQO2
Description: N-ribosyldihydronicotinamide:quinone reductase 2
Alias: DHQV, DIA6, NMOR2, QR2, ribosyldihydronicotinamide dehydrogenase [quinone], NAD(P)H dehydrogenase, quinone 2, NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2, NAD(P)H quinone dehydrogenase 2, NRH:quinone oxidoreductase 2, quinone reductase 2, ribosyldihydronicotinamide dehydrogenase
Species: human

Top Publications

  1. ncbi NAD(P)H:quinone oxidoreductase 1 and nrh:quinone oxidoreductase 2 activity and expression in bladder and ovarian cancer and lower NRH:quinone oxidoreductase 2 activity associated with an NQO2 exon 3 single-nucleotide polymorphism
    David Jamieson
    Northern Institute for Cancer Research, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Clin Cancer Res 13:1584-90. 2007
  2. ncbi Cellular knock-down of quinone reductase 2: a laborious road to successful inhibition by RNA interference
    Pascale Chomarat
    Pharmacologie Moléculaire et Cellulaire, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
    Biochimie 89:1264-75. 2007
  3. ncbi An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: glutathione S-transferase M1 and quinone oxidoreductase 1 and 2
    S Harada
    Institute of Community Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305 8575, Japan
    Biochem Biophys Res Commun 288:887-92. 2001
  4. pmc Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)
    Q Zhao
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 94:1669-74. 1997
  5. ncbi Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase
    K Wu
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Arch Biochem Biophys 347:221-8. 1997
  6. ncbi Crystal structure of human quinone reductase type 2, a metalloflavoprotein
    C E Foster
    Department of Biophysics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biochemistry 38:9881-6. 1999
  7. ncbi Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy
    R J Knox
    Enact Pharma PLC, Salisbury, United Kingdom
    Cancer Res 60:4179-86. 2000
  8. ncbi Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines
    Jesse J Kwiek
    Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710, USA
    Biochemistry 43:4538-47. 2004
  9. pmc Crystal structure of quinone reductase 2 in complex with resveratrol
    Leonid Buryanovskyy
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    Biochemistry 43:11417-26. 2004
  10. ncbi Crystal structure of quinone reductase 2 in complex with cancer prodrug CB1954
    Yue Fu
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Biochem Biophys Res Commun 336:332-8. 2005

Research Grants

  1. David Ross; Fiscal Year: 2014
  2. ANIL KUMAR JAISWAL; Fiscal Year: 2015
  3. ANIL KUMAR JAISWAL; Fiscal Year: 2016
  4. ANIL KUMAR JAISWAL; Fiscal Year: 2014
  5. Structure/Function Studies of Quinone Reductase 2
    Zhongtao Zhang; Fiscal Year: 2009
  6. Novel Direct Approaches Toward Bioactive Heterocycles
    Vladimir Gevorgyan; Fiscal Year: 2013
  7. NQO2: A novel target to reduce oxidative stress in retinal pigment epithelium
    CHRISTOPHER KWAN HWANG; Fiscal Year: 2011
  8. Targeting of NQ02 in CML
    David Ross; Fiscal Year: 2010
  9. STRUCTURE AND MECHANISMS OF NAD (P): QUINONE REDUCTASE
    L Amzel; Fiscal Year: 2005
  10. Chemoprevention of prostate cancer by resveratrol
    Tze Chen Hsieh; Fiscal Year: 2005

Scientific Experts

Detail Information

Publications140 found, 100 shown here

  1. ncbi NAD(P)H:quinone oxidoreductase 1 and nrh:quinone oxidoreductase 2 activity and expression in bladder and ovarian cancer and lower NRH:quinone oxidoreductase 2 activity associated with an NQO2 exon 3 single-nucleotide polymorphism
    David Jamieson
    Northern Institute for Cancer Research, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Clin Cancer Res 13:1584-90. 2007
    NRH:quinone oxidoreductase 2 (NQO2) is a homologue of NAD(P)H:quinone oxidoreductase 1 (NQO1). Despite 54% homology with human NQO1, NQO2 has little endogenous enzymatic activity...
  2. ncbi Cellular knock-down of quinone reductase 2: a laborious road to successful inhibition by RNA interference
    Pascale Chomarat
    Pharmacologie Moléculaire et Cellulaire, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
    Biochimie 89:1264-75. 2007
    NRH:quinone oxidoreductase 2 (QR2) is a long forgotten oxidoreductive enzyme that metabolizes quinones and binds melatonin...
  3. ncbi An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: glutathione S-transferase M1 and quinone oxidoreductase 1 and 2
    S Harada
    Institute of Community Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305 8575, Japan
    Biochem Biophys Res Commun 288:887-92. 2001
    ..GSTM1), NAD(P)H:quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) are important as cellular defenses against catecholamine-derived quinones and the oxidative stress that arises as ..
  4. pmc Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)
    Q Zhao
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 94:1669-74. 1997
    ..Williams-Ashman (1962) J. Biol. Chem. 237, 2981-2987]. This enzyme is designated here as quinone reductase type 2 (QR2). Bovine QR2 is a homodimer that migrates on SDS/PAGE at approximately 22 kDa...
  5. ncbi Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase
    K Wu
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Arch Biochem Biophys 347:221-8. 1997
    Human NAD(P)H:quinone acceptor oxidoreductase-2 (NQO2) has been prepared using an Escherichia coli expression method. NQO2 is thought to be an isoform of DT-diaphorase (EC 1.6.99...
  6. ncbi Crystal structure of human quinone reductase type 2, a metalloflavoprotein
    C E Foster
    Department of Biophysics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biochemistry 38:9881-6. 1999
    ..6.99.2) and quinone reductase type 2 (QR2)...
  7. ncbi Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy
    R J Knox
    Enact Pharma PLC, Salisbury, United Kingdom
    Cancer Res 60:4179-86. 2000
    ..The enzyme is NQO2 [NAD(P)H quinone oxidoreductase 2], but its activity is normally latent, and a nonbiogenic co-substrate such as NRH ..
  8. ncbi Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines
    Jesse J Kwiek
    Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27710, USA
    Biochemistry 43:4538-47. 2004
    Quinone oxidoreductase 2 (QR2) purified from human red blood cells was recently shown to be a potential target of the quinoline antimalarial compounds [Graves et al., (2002) Mol. Pharmacol. 62, 1364]...
  9. pmc Crystal structure of quinone reductase 2 in complex with resveratrol
    Leonid Buryanovskyy
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    Biochemistry 43:11417-26. 2004
    ..Here, we report that resveratrol is a potent inhibitor of quinone reductase 2 (QR2) activity in vitro with a dissociation constant of 35 nM and show that it specifically binds to the ..
  10. ncbi Crystal structure of quinone reductase 2 in complex with cancer prodrug CB1954
    Yue Fu
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Biochem Biophys Res Commun 336:332-8. 2005
    ..Human quinone reductase 2 is very efficient in the activation of CB1954, approximately 3000 times more efficient than human QR1 in ..
  11. ncbi NRH:quinone oxidoreductase 2 and NAD(P)H:quinone oxidoreductase 1 protect tumor suppressor p53 against 20s proteasomal degradation leading to stabilization and activation of p53
    Xing Gong
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 67:5380-8. 2007
    ..The cytosolic quinone oxidoreductases [NRH:quinone oxidoreductase 2 (NQO2) and NAD(P)H:quinone oxidoreductase 1 (NQO1)] interacted with p53 and protected p53 against 20S proteasomal ..
  12. pmc Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2
    Barbara Calamini
    Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The University of Illinois at Chicago, 900 S Ashland Ave M C 870, Chicago, IL 60607, USA
    Biochem J 413:81-91. 2008
    ..MT3 has recently been identified as QR2 (quinone reductase 2) (EC 1.10.99...
  13. doi Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive decline
    Antony Payton
    Centre for Integrated Genomic Medical Research, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Neurobiol Aging 31:351-2. 2010
    NAD(P)H dehydrogenase quinone 2 (NQO2) is a quinone reductase whose functions include the reduction of both oxidative stress during the redox cycle and neurotoxicity caused by the metabolism of catecholamines...
  14. pmc Quinone reductase 2 is a catechol quinone reductase
    Yue Fu
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    J Biol Chem 283:23829-35. 2008
    The functions of quinone reductase 2 have eluded researchers for decades even though a genetic polymorphism is associated with various neurological disorders...
  15. doi Superoxide dismutase and nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase polymorphisms and pancreatic cancer risk
    Beatrice Mohelnikova-Duchonova
    Toxicogenomics Unit, National Institute of Public Health, Prague, Czech Republic
    Pancreas 40:72-8. 2011
    ..dismutase 2 (SOD2 [Ala16Val, rs4880]), SOD3 (Arg231Gly, rs1799895), nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase (NQO1 [Pro187Ser, rs1800566], and NQO2 (Phe47Leu, rs1143684) with pancreatic cancer risk was studied.
  16. doi Association of superoxide dismutases and NAD(P)H quinone oxidoreductases with prognosis of patients with breast carcinomas
    Miluse Hubackova
    Toxicogenomics Unit, National Institute of Public Health, Prague, Czech Republic
    Int J Cancer 130:338-48. 2012
    Associations of transcript levels of oxidative stress-modifying genes SOD2, SOD3, NQO1 and NQO2 and their functional single nucleotide polymorphisms (SNPs) rs4880, rs1799895, rs2536512, rs699473, rs1800566 and rs1143684 with prognosis of ..
  17. doi Two minor NQO1 and NQO2 alleles predict poor response of breast cancer patients to adjuvant doxorubicin and cyclophosphamide therapy
    David Jamieson
    Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, Newcastle University, Newcastle upon Tyne, UK
    Pharmacogenet Genomics 21:808-19. 2011
    ..NQO1, and its homologue NQO2, share many substrates yet retain distinct functional differences, with NQO2 being a more permissive molecule for ..
  18. pmc Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii
    C J Carter
    176 Downs Road, Hastings, East Sussex, TN34 2DZ, UK
    Schizophr Bull 35:1163-82. 2009
    ..components bind to genes or proteins encoded by CALR, FEZ1, FYN, HSPA1B, IL2, HTR2A, KPNA3, MED12, MED15, MICB, NQO2, PAX6, PIK3C3, RANBP5, or TP53, while the cerebral infectivity of the herpes simplex virus is modified by ..
  19. ncbi NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs
    Claudia M Celli
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Biochem Pharmacol 72:366-76. 2006
    NRH:quinone oxidoreductase 2 (NQO2) is a cytosolic flavoprotein that utilizes NRH as electron donor. The present studies investigate the role of NQO2 in metabolic detoxification/activation of quinones and quinone based anti-tumor drugs...
  20. pmc Signaling pathways involved in phase II gene induction by alpha, beta-unsaturated aldehydes
    Hongqiao Zhang
    School of Natural Science, University of California at Merced, Merced, CA 95343, USA
    Toxicol Ind Health 25:269-78. 2009
    ..Two electrophiles, 4-hydroxynonenal (HNE) and acrolein, induced the expression of phase II genes (GCLC, GCLM, NQO1, NQO2, HO-1, and GSTM-1)...
  21. pmc A single-electron reducing quinone oxidoreductase is necessary to induce haustorium development in the root parasitic plant Triphysaria
    Pradeepa C G Bandaranayake
    Department of Crop Science, Faculty of Agriculture, University of Peradeniya, Peradeniya, Sri Lanka 20400
    Plant Cell 22:1404-19. 2010
    ..QR1 encodes a single-electron reducing NADPH quinone oxidoreductase similar to zeta-crystallin. The QR2 enzyme catalyzes two electron reductions typical of xenobiotic detoxification...
  22. pmc Evidence for NQO2-mediated reduction of the carcinogenic estrogen ortho-quinones
    Nilesh W Gaikwad
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Free Radic Biol Med 46:253-62. 2009
    ..A similar detoxification role has not been established for its homologue NRH:quinone oxidoreductase 2 (NQO2)...
  23. doi 5-MCA-NAT does not act through NQO2 to reduce intraocular pressure in New-Zealand white rabbit
    Pilar Alarma-Estrany
    Departamento Bioquimica, E U Optica, Universidad Complutense de Madrid, c Arcos de Jalon s n, 28037 Madrid, Spain
    J Pineal Res 47:201-9. 2009
    Solid data support the idea that the MT(3) melatonin binding site is an enzyme, quinone reductase 2 (NQO2), rather than a membrane melatonin receptor...
  24. ncbi Aerobic nitroreduction by flavoproteins: enzyme structure, mechanisms and role in cancer chemotherapy
    J V Skelly
    School of Chemical and Life Sciences, University of Greenwich, Wellington Street, Woolwich, London, SE18 6PF, UK
    Mini Rev Med Chem 1:293-306. 2001
    NQO1 (DT-diaphorase) and its truncated isoenzyme, the metalloenzyme NQO2, can reduce quinone substrates by two-electron transfer. While NQO1 is a known detoxification enzyme, the function of NQO2 is less well understood...
  25. ncbi [Clozapine-induced agranulocytosis: genetic risk factors and an immunologic explanatory model]
    Y Guzelcan
    Jeroen Bosch Ziekenhuis, PAAZ van locatie Carolus, s Hertogenbosch
    Tijdschr Psychiatr 48:295-302. 2006
    ..Clozapine, an atypical antipsychotic used in the treatment of refractory schizophrenia, causes agranulocytosis in 0.8% of patients. The risk factors for clozapine-induced agranulocytosis (CIA) and the underlying mechanisms are unclear...
  26. ncbi Melatonin as a naturally occurring co-substrate of quinone reductase-2, the putative MT3 melatonin membrane receptor: hypothesis and significance
    Dun Xian Tan
    Department of Cellular and Structural Biology, University of Texas, Health Science Center, San Antonio, TX 78229 3900, USA
    J Pineal Res 43:317-20. 2007
    ..Moreover, solid data support the idea that the MT3 melatonin binding site is an enzyme, quinone reductase 2 (QR2), rather than a membrane melatonin receptor...
  27. pmc Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?
    R Jockers
    Department of Cell Biology, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Br J Pharmacol 154:1182-95. 2008
    ..A third melatonin-binding site has been purified and characterized as the enzyme quinone reductase 2 (QR2)...
  28. doi Theoretical determination of the redox potentials of NRH:quinone oxidoreductase 2 using quantum mechanical/molecular mechanical simulations
    James C Rauschnot
    Department of Chemistry, University of Wisconsin Eau Claire, 105 Garfield Avenue, Eau Claire, Wisconsin 54702, USA
    J Phys Chem B 113:8149-57. 2009
    NRH:quinone oxidoreductase 2 (NQO2) is a flavoenzyme that catalyzes a one-step two-electron reduction of quinones...
  29. pmc Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities
    Arup Maiti
    Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, and the Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907, USA
    J Med Chem 52:1873-84. 2009
    ..The route was versatile enough to provide an array of compound 1 analogues that were evaluated as QR2 and aromatase inhibitors...
  30. pmc The melatonin-producing system is fully functional in retinal pigment epithelium (ARPE-19)
    Michał A Zmijewski
    Department of Molecular Enzymology, Intercollegiate Faculty of Biotechnology of University of Gdańsk, Medical University of Gdansk, Gdansk, Poland
    Mol Cell Endocrinol 307:211-6. 2009
    ..MT2 (but not MT1), two isoforms of nuclear receptor (RORalpha1 and RORalpha4/RZR1), and quinone oxidoreductase (NQO2)...
  31. ncbi Deficiency of NRH:quinone oxidoreductase 2 increases susceptibility to 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene-induced skin carcinogenesis
    Karim Iskander
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 64:5925-8. 2004
    NRH:Quinone oxidoreductase 2 (NQO2) is an enzyme that catalyzes the reductive metabolism of quinones. C57BL/6 NQO2-/- mice lacking NQO2 gene expression were generated in our laboratory...
  32. ncbi NQO1 and NQO2 regulation of humoral immunity and autoimmunity
    Karim Iskander
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 281:30917-24. 2006
    NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) are cytosolic enzymes that catalyze metabolic reduction of quinones and derivatives...
  33. ncbi Quinone oxidoreductases in protection against myelogenous hyperplasia and benzene toxicity
    Karim Iskander
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Chem Biol Interact 153:147-57. 2005
    Quinone oxidoreductases (NQO1 and NQO2) are cytosolic proteins that catalyze metabolic reduction of quinones and its derivatives to protect cells against redox cycling and oxidative stress...
  34. ncbi Synthesis of cryptolepine analogues as potential bioreducible anticancer agents
    Scott Seville
    The School of Pharmacy, University of Bradford, Bradford, West Yorkshire BD7 1DP, UK
    Bioorg Med Chem 15:6353-60. 2007
    ..properties as well as their potential for reductive activation by the cytosolic reductase enzymes NQO1 and NQO2. Molecular modelling studies suggest that cryptolepine is able to fit into the active site of NQO2 and thus raising ..
  35. ncbi [Melatonin binding site MT3 is QR2: state of the art]
    Jean A Boutin
    Pharmacologie Moléculaire et Cellulaire, Institut de Recherches Servier, 125, Chemin de Ronde, 78290 Croissy sur Seine
    J Soc Biol 201:97-103. 2007
    ..This last binding site has been purified in our laboratory and is designated as quinone reductase 2 (QR2, E.C. 1.10.99.2). This enzyme has several individualistic features...
  36. ncbi Antiproliferative effects of resveratrol and the mediating role of resveratrol targeting protein NQO2 in androgen receptor-positive, hormone-non-responsive CWR22Rv1 cells
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Anticancer Res 29:3011-7. 2009
    ..context of modulation of growth suppression and NF-kappaB expression as mediated by resveratrol targeting protein NQO2, using both control and NQO2 siRNA silenced CWR22Rv1 cells...
  37. pmc Inactivation of the quinone oxidoreductases NQO1 and NQO2 strongly elevates the incidence and multiplicity of chemically induced skin tumors
    Jun Shen
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 70:1006-14. 2010
    The cytosolic quinone oxidoreductases NQO1 and NQO2 protect cells against oxidative stress by detoxifying quinones and preventing redox cycling...
  38. doi Quinone oxidoreductase-2-mediated prodrug cancer therapy
    Mark R Middleton
    Department of Medical Oncology, Churchill Hospital, Headington, Oxford OX3 7LJ, UK
    Sci Transl Med 2:40ra50. 2010
    DNA-damaging agents are widely used in cancer treatment despite their lack of tumor specificity. Human NQO2 (quinone oxidoreductase-2) is an atypical oxidoreductase because no endogenous electron donor has been identified to date...
  39. ncbi Organs from mice deleted for NRH:quinone oxidoreductase 2 are deprived of the melatonin binding site MT3
    François Mailliet
    Pharmacologie Moléculaire et Cellulaire, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
    FEBS Lett 578:116-20. 2004
    ..We previously reported the purification of MT3 and identified it as the enzyme dihydronicotinamide riboside:quinone reductase 2 (NQO2). To investigate the relationship between NQO2 and MT3, we generated a NQO2-/- mouse strain...
  40. pmc The role of c-Jun phosphorylation in EpRE activation of phase II genes
    Smadar Levy
    School of Natural Sciences, University of California at Merced, Merced, CA 95340, USA
    Free Radic Biol Med 47:1172-9. 2009
    ..used chromatin immunoprecipitation assays to measure the recruitment of transcription factors to EpRE sequences in NQO2, GCLC, and GCLM; Western analysis for phosphorylation of JNK; and EpRE-driven reporters along with a JNK-specific ..
  41. doi In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2)
    Karen A Nolan
    School of Pharmacy and Pharmaceutical Sciences, University of Manchester and Manchester Cancer Research Center, Manchester, UK
    Bioorg Med Chem Lett 20:7331-6. 2010
    ..database has been screened using in silico docking to identify novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2)...
  42. ncbi Human dioxin-inducible cytosolic NAD(P)H:menadione oxidoreductase. cDNA sequence and localization of gene to chromosome 16
    A K Jaiswal
    Department of Cell Biology, New York University Medical Center, New York 10016
    J Biol Chem 263:13572-8. 1988
    ..Southern analysis of DNA from 54 human x mouse and 39 human x hamster somatic cell hybrids shows that the NMOR1 gene resides on human chromosome 16...
  43. pmc Presence of a heterozygous substitution and its relationship to DT-diaphorase activity
    B L Kuehl
    Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Br J Cancer 72:555-61. 1995
    ..All cell strains expressed NQO1 and NQO2 mRNA as measured by a quantitative polymerase chain reaction amplification technique...
  44. ncbi Mouse dioxin-inducible NAD(P)H: menadione oxidoreductase: NMO1 cDNA sequence and genetic differences in mRNA levels
    V Vasiliou
    Department of Environmental Health, University of Cincinnati Medical Center, OH 45267 0056
    Pharmacogenetics 4:341-8. 1994
    ..5% to the human NMO1 proteins; 49.3% identical to the human NQO2 protein; and < 20% similar to several dozen other proteins in the quinone oxidoreductase superfamily...
  45. ncbi Structure-function studies of DT-diaphorase (NQO1) and NRH: quinone oxidoreductase (NQO2)
    S Chen
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Free Radic Biol Med 29:276-84. 2000
    ..NRH (dihydronicotinamide riboside): quinone oxidoreductase, also referred to as NQO2, has a high nucleotide sequence identity to DT-diaphorase and is considered to be an isozyme of DT-diaphorase...
  46. ncbi CB 1954: from the Walker tumor to NQO2 and VDEPT
    Richard J Knox
    Enact Pharma PLC, Porton Down Scientific Park, Salisbury, Wiltshire, UK
    Curr Pharm Des 9:2091-104. 2003
    ..Recently it has been shown that a latent nitroreductase is present in some human tumors. This is NQO2--an enzyme that requires for activity, the non-biogenic compound dihydronicotinamide riboside (NRH) as a ..
  47. pmc Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family
    Vasilis Vasiliou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Hum Genomics 2:329-35. 2006
    ..NQO) gene family belongs to the flavoprotein clan and, in the human genome, consists of two genes (NQO1 and NQO2)...
  48. ncbi BALT development and augmentation of hyperoxic lung injury in mice deficient in NQO1 and NQO2
    Amitava Das
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Free Radic Biol Med 40:1843-56. 2006
    NAD(P)H/NRH:quinone oxidoreductases (NQO1 and NQO2) protect against oxidative stress and neoplasia. Cross-breeding of NQO1-/- with NQO2-/- mice generated double-knockout (DKO) mice...
  49. ncbi Caenorhabditis elegans mutants having altered preference of chemotaxis behavior during simultaneous presentation of two chemoattractants
    Lin Lin
    Department of Computer and Information Science, Graduate School of Engineering, Iwate University, Ueda, Morioka, Japan
    Biosci Biotechnol Biochem 70:2754-8. 2006
    ..The chep-1(qr1) (CHEmosensory Preference) mutant preferred sodium acetate to diacetyl, while the chep-2(qr2) mutant preferred diacetyl to sodium acetate in simultaneous presentation of these chemoattractants...
  50. ncbi Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
    Marcus Bantscheff
    Cellzome AG, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Nat Biotechnol 25:1035-44. 2007
    ..known targets including ABL and SRC family kinases and identifies the receptor tyrosine kinase DDR1 and the oxidoreductase NQO2 as novel targets of imatinib. The data suggest that our approach is a valuable tool for drug discovery.
  51. ncbi In vivo role of NAD(P)H:quinone oxidoreductase 1 in metabolic activation of mitomycin C and bone marrow cytotoxicity
    Anbu Karani Adikesavan
    Department of Pharmacology, Baylor College of Medicine and Department of Pathology, Methodist Hospital, Houston, TX, USA
    Cancer Res 67:7966-71. 2007
    NAD(P)H:quinone oxidoreductase 1(-/-) (NQO1(-/-)), NQO1(+/-) along with NRH:quinone oxidoreductase 2(-/-) (NQO2(-/-)), and wild-type (WT) mice were exposed to five once weekly doses of mitomycin C...
  52. pmc Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata
    Jian hong Yang
    Department of Chemistry, Yunnan Normal University, Kunming, People s Republic of China
    Phytochemistry 71:641-7. 2010
    ..necrosis factor alpha (TNF-alpha)-induced NF-kappaB activity, nitric oxide (NO) production, aromatase, quinone reductase 2 (QR2) and COX-1/-2 activities...
  53. pmc Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer
    Bin Sun
    Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, and the Purdue Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States
    Bioorg Med Chem 18:5352-66. 2010
    ..In addition to aromatase inhibitory activity, compounds 32 and 44 also displayed potent QR2 inhibitory activity (IC50 1.7 microM and 0...
  54. pmc Resveratrol: Biological and pharmaceutical properties as anticancer molecule
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY, USA
    Biofactors 36:360-9. 2010
    ..we will review examples resveratrol-target proteins, denoted RTPs, including the 24-kDa cytosolic protein quinone reductase 2 (NQO2) discovered in our laboratory that may confer resveratrol responsiveness to cancer cells...
  55. doi Quinone reductase 2 and antidepressant effect of melatonin derivatives
    Gregory F Oxenkrug
    Department of Psychiatry, Tufts University Tufts Medical Center, Boston, Massachusetts 02111, USA
    Ann N Y Acad Sci 1199:121-4. 2010
    ..Melatonin type 3 receptor (MT3) was identified as the same protein as quinone reductase 2 (QR2) detoxifying and antioxidant enzyme...
  56. pmc Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from Streptomyces species, strain CNS284
    Martin Conda-Sheridan
    Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and the Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA
    J Med Chem 53:8688-99. 2010
    ..were subsequently prepared and evaluated as inducers of quinone reductase 1 (QR1) and inhibitors of quinone reductase 2 (QR2), NF-κB, and inducible nitric oxide synthase (iNOS)...
  57. pmc NQO1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels
    Roman H Haefeli
    Santhera Pharmaceuticals, Liestal, Switzerland
    PLoS ONE 6:e17963. 2011
    ..we observed that contrary to CoQ10 short-chain quinones such as idebenone are good substrates for both NQO1 and NQO2. Furthermore, the reduction of short-chain quinones by NQOs enabled an antimycin A-sensitive transfer of electrons ..
  58. doi Ah receptor- and Nrf2-gene battery members: modulators of quinone-mediated oxidative and endoplasmic reticulum stress
    Karl Walter Bock
    Deparment of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Tubingen, Wilhelmstrasse 56, D 72074 Tubingen, Germany
    Biochem Pharmacol 83:833-8. 2012
    ..Two pathways are emphasized: (i) glutathione S-transferases, and (ii) NAD(P)H:quinone oxidoreductases NQO1 and NQO2 acting together with UDP-glucuronosyltransferases and sulfotransferases...
  59. pmc The antidote effect of quinone oxidoreductase 2 inhibitor against paraquat-induced toxicity in vitro and in vivo
    Elzbieta Janda
    Department of Health Sciences, University Magna Graecia, Catanzaro, Italy
    Br J Pharmacol 168:46-59. 2013
    ..NMDPEF), a melatonin-related inhibitor of quinone oxidoreductase2 (QR2) on the toxicity of PQ in vitro & in vivo...
  60. doi Downregulation of quinone reductase 2 attenuates vascular smooth muscle cells proliferation and neointimal formation in balloon injured rat carotid artery
    Xi Wen Zhang
    Department of Cardiology, Huai an First People s Hospital affiliated to Nanjing Medical University, Huai an, Jiangsu
    Cell Physiol Biochem 29:453-62. 2012
    b>Quinone reductase 2 (NQO2) is a flavoprotein that catalyzes the metabolic reduction of quinines, but its biological mechanism in vascular smooth muscle cells (VSMCs) is unclear...
  61. pmc The transcription factor NF-E2-related factor 2 (Nrf2): a protooncogene?
    Phillip Shelton
    Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    FASEB J 27:414-23. 2013
    ..Herein, we highlight the ways in which Nrf2 is regulated, and discuss some of the Nrf2-inducible antioxidant (NQO1, NQO2, HO-1, GCLC), antiapoptotic (Bcl-2), metabolic (G6PD, TKT, PPARγ), and drug efflux transporter (ABCG2, MRP3, MRP4) ..
  62. doi Disturbed balance between phase I and II metabolizing enzymes in ovarian endometriosis: a source of excessive hydroxy-estrogens and ROS?
    Neli Hevir
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
    Mol Cell Endocrinol 367:74-84. 2013
    ..Expression of CYP1B1, CYP3A5, SULT1A1 and NQO2 was unchanged, with comparable CYP1B1 protein levels...
  63. doi Evidence for NQO1 and NQO2 catalyzed reduction of ortho- and para-quinone methides
    H R Kucera
    Department of Nutrition, University of California, Davis, CA, USA
    Free Radic Res 47:1016-26. 2013
    quinone oxidoreductase (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) catalyze the two-electron reduction of quinones and thereby prevent generation of toxic radicals...
  64. pmc The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties
    Clare F Megarity
    School of Biological Sciences, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    FEBS Lett 588:1666-72. 2014
    There are two common forms of NRH-quinone oxidoreductase 2 (NQO2) in the human population resulting from SNP rs1143684. One has phenylalanine at position 47 (NQO2-F47) and the other leucine (NQO2-L47)...
  65. doi Identification of one-electron reductases that activate both the hypoxia prodrug SN30000 and diagnostic probe EF5
    Jingli Wang
    Auckland Cancer Society Research Centre, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Biochem Pharmacol 91:436-46. 2014
    ..with known or suspected roles in bioreductive prodrug metabolism (AKR1C3, CYB5R3, FDXR, MTRR, NDOR1, NOS2A, NQO1, NQO2 and POR) enhances oxic or anoxic reduction of SN30000 and EF5 by HCT116 cells...
  66. doi Interleukin-32α modulates promyelocytic leukemia zinc finger gene activity by inhibiting protein kinase Cɛ-dependent sumoylation
    Yun Sun Park
    Department of Bioscience and Biotechnology, Bio Molecular Informatics Center, Konkuk University, Seoul 143 701, Republic of Korea
    Int J Biochem Cell Biol 55:136-43. 2014
    ..Together, our data suggest that IL-32α associates with PLZF and PKCɛ, and then inhibits PLZF sumoylation, resulting in suppression of the transcriptional activity of PLZF. ..
  67. doi Melatonin inhibits granulocyte adhesion to ICAM via MT3/QR2 and MT2 receptors
    Vitalij Cernysiov
    Department of Immunology, State Research Institute Centre for Innovative Medicine, LT 08409 Vilnius, Lithuania
    Int Immunol 27:599-608. 2015
    ..This study additionally showed that melatonin receptors MT2 and MT3/quinone reductase 2 (QR2) are expressed on granulocytes...
  68. doi Binding of DNA-Intercalating Agents to Oxidized and Reduced Quinone Reductase 2
    Kevin K K Leung
    Department of Biochemistry, University of Western Ontario, 1151 Richmond Street, London, Ontario, Canada N6A 5C1
    Biochemistry 54:7438-48. 2015
    b>Quinone reductase 2 (NQO2) is an enzyme that might have intracellular signaling functions...
  69. doi Genetic risk factors for clozapine-induced neutropenia and agranulocytosis in a Dutch psychiatric population
    K van der Weide
    Department of Clinical Chemistry, St Jansdal Hospital, Harderwijk, The Netherlands
    Pharmacogenomics J . 2016
    ..NQO2 1541AA (NRH quinone oxidoreductase 2; protects cells against oxidative metabolites) was present at a higher frequency in agranulocytosis ..
  70. ncbi Redox properties of the [2Fe-2S] center in the 24 kDa (NQO2) subunit of NADH:ubiquinone oxidoreductase (complex I)
    Yanbing Zu
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, U K
    Biochemistry 41:10056-69. 2002
    ..Finally, the validity of using the [2Fe-2S] cluster in an isolated subunit, as a mechanistic basis for coupled proton-electron transfer in intact complex I, is evaluated...
  71. pmc NRH:quinone oxidoreductase 2 (NQO2) protein competes with the 20 S proteasome to stabilize transcription factor CCAAT enhancer-binding protein α (C/EBPα), leading to protection against γ radiation-induced myeloproliferative disease
    Junkang Xu
    From the Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland 21201
    J Biol Chem 288:34799-808. 2013
    NRH:quinone oxidoreductase 2 (NQO2) is a flavoprotein that protects cells against radiation and chemical-induced oxidative stress. Disruption of the NQO2 gene in mice leads to γ radiation-induced myeloproliferative diseases...
  72. ncbi Differential regulation of wheat quinone reductases in response to powdery mildew infection
    David L Greenshields
    Department of Biology, University of Saskatchewan, Saskatoon, SK, S7N 5E2, Canada
    Planta 222:867-75. 2005
    ..the univalent reduction of quinones to semiquinone radicals, and (2) the DT-diaphorase-like quinone reductases (QR2, EC 1.6.99.2) that catalyze the divalent reduction of quinones to hydroquinones...
  73. ncbi In silico and biochemical analyses identify quinone reductase 2 as a target of piceatannol
    Tze Chen Hsieh
    Research Associate Professor, Room 133, Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Curr Med Chem 20:4195-202. 2013
    ..To determine whether quinone reductase 2 (NQO2) plays a role in the observed effects, in silico analysis was performed...
  74. pmc Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2
    Sarah E St John
    Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States
    Bioorg Med Chem 21:6022-37. 2013
    ..The highest affinity target of resveratrol identified so far is the oxidoreductase enzyme quinone reductase 2 (QR2), which is believed to function in metabolic reduction and detoxification processes; however, evidence ..
  75. pmc Chloroquine binding reveals flavin redox switch function of quinone reductase 2
    Kevin K K Leung
    Department of Biochemistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 288:11242-51. 2013
    b>Quinone reductase 2 (NQO2) is an FAD-linked enzyme and the only known human target of two antimalarial drugs, primaquine (PQ) and chloroquine (CQ)...
  76. pmc Resveratrol inhibits angiotensin II-induced ERK1/2 activation by downregulating quinone reductase 2 in rat vascular smooth muscle cells
    Xiwen Zhang
    Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China
    J Biomed Res 26:103-9. 2012
    ..the proliferation of vascular smooth muscle cells (VSMCs) and repress mRNA and protein expression of quinone reductase 2 (NQO2)...
  77. doi Genetic variants in metabolizing genes NQO1, NQO2, MTHFR and risk of prostate cancer: a study from North India
    Raju K Mandal
    Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, Uttar Pradesh, India
    Mol Biol Rep 39:11145-52. 2012
    Quinone oxidoreductases (NAD(P)H): quinone oxidoreductase 1 (NQO1) and NRH: quinone oxidoreductase 2 (NQO2) are an antioxidant enzyme, important in the detoxification of environmental carcinogens...
  78. doi Structural characterization of HP1264 reveals a novel fold for the flavin mononucleotide binding protein
    Ki Young Lee
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    Biochemistry 52:1583-93. 2013
    ..However, Helicobacter pylori has an unusual complex I that lacks typical NQO1 and NQO2 subunits, both of which are generally included in the NADH dehydrogenase domain of complex I...
  79. doi NAD(P)H: quinone oxidoreductase 1 and its potential protective role in cardiovascular diseases and related conditions
    Hong Zhu
    Division of Biomedical Sciences, Edward Via College of Osteopathic Medicine, Virginia Tech Corporate Research Center, Blacksburg, VA 24060, USA
    Cardiovasc Toxicol 12:39-45. 2012
    ..In mammalian systems, there are two members of NQO, namely, NQO1 and NQO2. NQO1 utilizes NAD(P)H, whereas NQO2 employs dihydronicotinamide riboside (NRH) as the electron donors...
  80. pmc Control of stability of cyclin D1 by quinone reductase 2 in CWR22Rv1 prostate cancer cells
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Room 133, Valhalla, NY 10595, USA
    Carcinogenesis 33:670-7. 2012
    ..prostate cancer prevention by resveratrol, focusing on the role of its recently discovered target protein, quinone reductase 2 (NQO2), we generated NQO2 knockdown CWR22Rv1 using short hairpin RNA (shRNA)-mediated gene silencing ..
  81. ncbi Human NAD(P)H:quinone oxidoreductase2. Gene structure, activity, and tissue-specific expression
    A K Jaiswal
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    J Biol Chem 269:14502-8. 1994
    Human NAD(P)H:quinone oxidoreductase2 (NQO2) gene, 1336 base pairs (bp) of the 5'-flanking region and 165 bp of the 3'-flanking region, have been sequenced...
  82. ncbi The proton-translocating NADH-quinone oxidoreductase (NDH-1) of thermophilic bacterium Thermus thermophilus HB-8. Complete DNA sequence of the gene cluster and thermostable properties of the expressed NQO2 subunit
    T Yano
    Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 272:4201-11. 1997
    ..The T. thermophilus NQO2 subunit was expressed in Escherichia coli...
  83. ncbi Localization of human NQO1 gene to chromosome 16q22 and NQO2-6p25 and associated polymorphisms
    A K Jaiswal
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Pharmacogenetics 9:413-8. 1999
  84. ncbi Characterization and partial purification of microsomal NAD(P)H:quinone oxidoreductases
    A K Jaiswal
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, 77030, USA
    Arch Biochem Biophys 375:62-8. 2000
    ..forms of quinone oxidoreductases [NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2)] were previously identified, purified, and cloned...
  85. ncbi Role of NAD(P)H:quinone oxidoreductase 1 (DT diaphorase) in protection against quinone toxicity
    P Joseph
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Biochem Pharmacol 60:207-14. 2000
    ..carcinogenicity in NQO1-/- mice may be related to the strain (C57BL/6) of mice used in the present study and/or due to poor BPQ absorption into the skin and/or due to detoxification of BPQ by cytosolic NRH:quinone oxidoreductase 2 (NQO2).
  86. ncbi Mouse NRH:quinone oxidoreductase (NQO2): cloning of cDNA and gene- and tissue-specific expression
    D J Long
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, TX, USA
    Gene 252:107-17. 2000
    The mouse NQO2 cDNA and gene with flanking regions were cloned and sequenced...
  87. ncbi Regulation of genes encoding NAD(P)H:quinone oxidoreductases
    A K Jaiswal
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Free Radic Biol Med 29:254-62. 2000
    NAD(P)H:quinone oxidoreductase (NQO1) and NRH:quinone oxidoreductase (NQO2) are flavoproteins that catalyze two-electron reduction and detoxification of quinones and its derivatives...
  88. ncbi Differential gene expression of NAD(P)H:quinone oxidoreductase and NRH:quinone oxidoreductase in human hepatocellular and biliary tissue
    Ahlke Strassburg
    Department of Chemistry, Cancer Center, University of California, San Diego, La Jolla, California 92093 0636, USA
    Mol Pharmacol 61:320-5. 2002
    NAD(P)H:quinone oxidoreductase (NQO1) and dihydronicotinamide riboside:quinone oxidoreductases (NQO2) are cytosolic flavoproteins that catalyze the two-electron reduction of quinones and quinoid compounds to hydroquinones, thereby ..
  89. ncbi Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity
    Delwin J Long
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:46131-9. 2002
    Dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) is a flavoenzyme that catalyzes the reductive metabolism of quinones...
  90. ncbi NQO2 gene is associated with clozapine-induced agranulocytosis
    O Ostrousky
    Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Ramat Gan, Israel
    Tissue Antigens 62:483-91. 2003
    ..A candidate gene, dihydronicotinamide riboside (NRH) quinone oxidoreductase 2 (NQO2), which is involved in detoxification of drugs, was selected...
  91. ncbi A possible association between an insertion/deletion polymorphism of the NQO2 gene and schizophrenia
    Shoji Harada
    Department of Biochemistry, School of Medicine, Keio University, Tokyo, Shinjuku ku, Japan
    Psychiatr Genet 13:205-9. 2003
    Glutathione-S-transferases, NAD(P)H: quinone oxidoreductase1 (NQO1) and NRH: quinone oxidoreductase2 (NQO2) provide important cellular defences against the neurotoxicity induced by catecholamine-derived o-quinones and oxidative stress ..
  92. ncbi No associations between Parkinson's disease and polymorphisms of the quinone oxidoreductase (NQO1, NQO2) genes
    Starlyn Okada
    Department of Environmental and Occupational Health Sciences, University of Washington, Box 357234, Seattle, WA 98195 7234, USA
    Neurosci Lett 375:178-80. 2005
    ..NAD[P]H): quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH): quinone oxidoreductase 2 (NQO2) detoxify quinones and quinonoid compounds...
  93. ncbi Morphological features, distribution and compartmental organization of the nicotinamide adenine dinucleotide phosphate reduced-diaphorase interneurons in the human striatum
    Javier Bernácer
    Departamento de Morfologia, Facultad de Medicina, Universidad Autonoma de Madrid, 28029 Madrid, Spain
    J Comp Neurol 489:311-27. 2005
    ..Knowledge of the density and distribution of these interneurons should advance our understanding of the organization of the normal human striatum and help to evaluate the effects of neurodegenerative processes on cell density...
  94. ncbi Functional polymorphism of the NQO2 gene is associated with methamphetamine psychosis
    Shintaro Ohgake
    Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
    Addict Biol 10:145-8. 2005
    ..We analysed the polymorphisms of NQO1 and NQO2 genes to elucidate the association with genetic vulnerability to MAP abuse in Japan...
  95. ncbi Therapeutic potential of melatonin ligands
    Philippe Delagrange
    Département des Sciences Expérimentales, Institut de Recherches Servier, Suresnes, France
    Chronobiol Int 23:413-8. 2006
    ..A third melatonin binding site has been purified and characterized as the enzyme quinone reductase 2 (QR2). The physiological role of this enzyme is not yet known...
  96. pmc Reduction of mitomycin C is catalysed by human recombinant NRH:quinone oxidoreductase 2 using reduced nicotinamide adenine dinucleotide as an electron donating co-factor
    D Jamieson
    Northern Institute for Cancer Research, University of Newcastle upon Tyne, Paul O Gorman Building, Medical School, Newcastle upon Tyne NE2 4HH, UK
    Br J Cancer 95:1229-33. 2006
    NRH:Quinone Oxidoreductase 2 (NQO2) has been described as having no enzymatic activity with nicotinamide adenine dinucleotide (NADH) or NADPH as electron donating cosubstrates...
  97. pmc Activation of dioxin response element (DRE)-associated genes by benzo(a)pyrene 3,6-quinone and benzo(a)pyrene 1,6-quinone in MCF-10A human mammary epithelial cells
    Scott W Burchiel
    The University of New Mexico College of Pharmacy Toxicology Program and Division of Biocomputing, Albuquerque, NM 87131, USA
    Toxicol Appl Pharmacol 221:203-14. 2007
    ..and 1,6-BPQ induced oxidative stress-associated genes (HMOX1, GCLC, GCLM, and SLC7A11), phase 2 enzyme genes (NQO1, NQO2, ALDH3A1), PAH metabolizing genes (CYP1B1, EPHX1, AKR1C1), and certain EGF receptor-associated genes (EGFR, IER3, ..
  98. ncbi Transthyretin: a key gene involved in the maintenance of memory capacities during aging
    Jonathan Brouillette
    Department of Neurology and Neurosurgery, Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada H4H 1R3
    Neurobiol Aging 29:1721-32. 2008
    ..in hippocampal gene expression of transthyretin (TTR), calcineurin, and NAD(P)H dehydrogenase quinone 2 (NQO2) were associated with memory deficits in aged animals...
  99. ncbi Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib, and dasatinib reveal novel kinase and nonkinase targets
    Uwe Rix
    Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna
    Blood 110:4055-63. 2007
    ..4) The oxidoreductase NQO2 was bound and inhibited by imatinib and nilotinib at physiologically relevant drug concentrations, representing the ..
  100. ncbi Deficiency of NRH:quinone oxidoreductase 2 differentially regulates TNF signaling in keratinocytes: up-regulation of apoptosis correlates with down-regulation of cell survival kinases
    Kwang Seok Ahn
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:10004-11. 2007
    NRH:quinone oxidoreductase 2 (NQO2) is a cytosolic flavoprotein that catalyzes the two-electron reduction of quinones and quinoid compounds to hydroquinones...
  101. ncbi SALMON: solvent accessibility, ligand binding, and mapping of ligand orientation by NMR spectroscopy
    Christian Ludwig
    CR UK Institute for Cancer Studies, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK
    J Med Chem 51:1-3. 2008
    Quinone oxidoreductase 2 (NQO2) binds the prodrug tretazicar (also known as CB1954, 5-(aziridin-1-yl)-2,4-dinitrobenzamide), which exhibits a profound antitumor effect in human cancers when administered together with caricotamide...

Research Grants16

  1. David Ross; Fiscal Year: 2014
    ..The major mammalian quinone reductases NQO1 and NQO2 are highly polymorphic with a high prevalence of variant alleles resulting in marked phenotypic changes...
  2. ANIL KUMAR JAISWAL; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): NAD (P)H:quinone oxidoreductase1 (NQO1) and NRH:quinone oxidoreductase2 (NQO2) are enzymes that generally detoxify quinones, and protect against oxidative stress...
  3. ANIL KUMAR JAISWAL; Fiscal Year: 2016
    ..Preliminary studies revealed that quinone oxidoreductases (NQO1 and NQO2) might protect against mammary toxicity, carcinogenicity and metastasis...
  4. ANIL KUMAR JAISWAL; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Nrf2/ARE-mediated coordinated activation of quinone oxidoreductases (NQO1 and NQO2), and other detoxifying enzyme gene expression, is one mechanism of critical importance in prevention of chemicals ..
  5. Structure/Function Studies of Quinone Reductase 2
    Zhongtao Zhang; Fiscal Year: 2009
    ..structural, biochemical, and biological approaches to study the structural/function relationship of quinone reductase 2 (QR2)...
  6. Novel Direct Approaches Toward Bioactive Heterocycles
    Vladimir Gevorgyan; Fiscal Year: 2013
    ..scaffolds, potential topoisomerase I inhibitors, and tetra- and pentacyclic heterocyclic skeletons, potential QR2 and aromatase inhibitors...
  7. NQO2: A novel target to reduce oxidative stress in retinal pigment epithelium
    CHRISTOPHER KWAN HWANG; Fiscal Year: 2011
    ..that pharmacological inhibition of the enzyme, N-ribosyl-dihydronicotinamide (NRH):quinone oxidoreductase 2 (NQO2), protects human RPE cells from this oxidative stress...
  8. Targeting of NQ02 in CML
    David Ross; Fiscal Year: 2010
    ..In a surprising and unexpected finding in 2007, NQO2 was identified as the first non-kinase target of imatinib in two independent studies...
  9. STRUCTURE AND MECHANISMS OF NAD (P): QUINONE REDUCTASE
    L Amzel; Fiscal Year: 2005
    ..of QR1 for chemotherapeutic agents, and to complete the elucidation of the function and the mechanism of QR2. Chemoprotection by QR is part of the coordinated response that involves the induction of phase II enzymes...
  10. Chemoprevention of prostate cancer by resveratrol
    Tze Chen Hsieh; Fiscal Year: 2005
    ....
  11. IMMUNOTOXICITY OF POLYCYCLIC AROMATIC HYDROCARBONS
    Scott Burchiel; Fiscal Year: 2001
    ..Finally, in Aim 4 we will assess the role of monocyte and P450 expression by Western blot and RT-PCR methods in subsets of HPBMC and human cell lines (above). ..
  12. Novel target proteins of resveratrol in chemoprevention
    Joseph Wu; Fiscal Year: 2005
    ..abstract_text> ..
  13. Functional synergism in prevention of hormone refractory CaP by phytochemicals
    Joseph Wu; Fiscal Year: 2007
    ..The data obtained will support the concept that combined diet-derived phytochemicals can offer easily compliant strategies for protection against HRPC. [unreadable] [unreadable] [unreadable]..