NQO1

Summary

Gene Symbol: NQO1
Description: NAD(P)H quinone dehydrogenase 1
Alias: DHQU, DIA4, DTD, NMOR1, NMORI, QR1, NAD(P)H dehydrogenase [quinone] 1, DT-diaphorase, NAD(P)H dehydrogenase, quinone 1, NAD(P)H:Quinone acceptor oxidoreductase type 1, NAD(P)H:menadione oxidoreductase 1, NAD(P)H:quinone oxidoreductase 1, NAD(P)H:quinone oxireductase, azoreductase, diaphorase (NADH/NADPH) (cytochrome b-5 reductase), diaphorase-4, dioxin-inducible 1, menadione reductase, phylloquinone reductase, quinone reductase 1
Species: human

Top Publications

  1. ncbi NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese
    Nobuyuki Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Int J Clin Oncol 7:103-8. 2002
  2. ncbi Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C-->T mutation and rapid fractional excretion of chlorzoxazone
    N Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 57:2839-42. 1997
  3. ncbi Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells
    Shannon L Winski
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 80017, USA
    Cancer Res 62:1420-4. 2002
  4. pmc Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cells
    Benjaporn Buranrat
    Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    World J Gastroenterol 16:2362-70. 2010
  5. pmc A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity
    J L Moran
    Department of Pharmaceutical Sciences, School of Pharmacy, Campus Box C238, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 96:8150-5. 1999
  6. pmc E3 ligase STUB1/CHIP regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) accumulation in aged brain, a process impaired in certain Alzheimer disease patients
    Peter Tsvetkov
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 286:8839-45. 2011
  7. doi Association between NQO1 C609T polymorphism and bladder cancer susceptibility: a systemic review and meta-analysis
    Min Gong
    Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Huinan Town, Shanghai, 201399, China
    Tumour Biol 34:2551-6. 2013
  8. ncbi The expression of NAD(P)H:quinone oxidoreductase 1 is high in human adipose tissue, reduced by weight loss, and correlates with adiposity, insulin sensitivity, and markers of liver dysfunction
    Jenny Palming
    Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Clin Endocrinol Metab 92:2346-52. 2007
  9. doi Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans
    Sang Yong Eom
    Department of Preventive Medicine, College of Medicine, Chungbuk National University, 12 Gaeshin Dong, Heungdok gu, Cheongju, Chungbuk, 361 763, Republic of Korea
    Cancer Causes Control 20:137-45. 2009
  10. pmc Association of human NAD(P)H:quinone oxidoreductase 1 (NQO1) polymorphism with development of acute lung injury
    Anita J Reddy
    Duke University Medical Center, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Durham, NC, USA
    J Cell Mol Med 13:1784-91. 2009

Research Grants

  1. Investigating gene x environment interaction using human exposures to O3 & LPS
    David B Peden; Fiscal Year: 2010
  2. Dependency of O-3 Induced Lung Mucus Hypersecretion on NQ01
    W Michael Foster; Fiscal Year: 2010
  3. Michelle Hernandez; Fiscal Year: 2014
  4. Alterations in membrane composition and function eith calorie restriction
    Jon J Ramsey; Fiscal Year: 2011
  5. David Ross; Fiscal Year: 2014
  6. Judith A Voynow; Fiscal Year: 2014
  7. Rita Ghosh; Fiscal Year: 2014
  8. ANIL KUMAR JAISWAL; Fiscal Year: 2015
  9. Bhagavatula Moorthy; Fiscal Year: 2016
  10. SOLOMON FIIFI OFORI-ACQUAH; Fiscal Year: 2016

Detail Information

Publications298 found, 100 shown here

  1. ncbi NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and the risk of eight cancers for Japanese
    Nobuyuki Hamajima
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Int J Clin Oncol 7:103-8. 2002
    NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T was reportedly associated with leukemia, lung cancer, colorectal cancer, and urological malignancies...
  2. ncbi Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C-->T mutation and rapid fractional excretion of chlorzoxazone
    N Rothman
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 57:2839-42. 1997
    ..To evaluate the impact of interindividual variation in enzymes that activate (i.e., CYP2E1) and detoxify (i.e., NQO1) benzene and its metabolites, we carried out a case-control study in Shanghai, China, of occupational benzene ..
  3. ncbi Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells
    Shannon L Winski
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado 80017, USA
    Cancer Res 62:1420-4. 2002
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is implicated in both chemoprevention and bioactivation of DNA-damaging antitumor agents...
  4. pmc Dicoumarol enhances gemcitabine-induced cytotoxicity in high NQO1-expressing cholangiocarcinoma cells
    Benjaporn Buranrat
    Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    World J Gastroenterol 16:2362-70. 2010
    To investigate whether dicoumarol, a potent inhibitor of NAD(P)H quinone oxidoreductase-1 (NQO1), potentiates gemcitabine to induce cytotoxicity in cholangiocarcinoma cells (CCA) and the role of reactive oxygen generation in sensitizing ..
  5. pmc A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity
    J L Moran
    Department of Pharmaceutical Sciences, School of Pharmacy, Campus Box C238, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 96:8150-5. 1999
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene...
  6. pmc E3 ligase STUB1/CHIP regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) accumulation in aged brain, a process impaired in certain Alzheimer disease patients
    Peter Tsvetkov
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 286:8839-45. 2011
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoenzyme that is important in maintaining the cellular redox state and regulating protein degradation...
  7. doi Association between NQO1 C609T polymorphism and bladder cancer susceptibility: a systemic review and meta-analysis
    Min Gong
    Department of Urology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Huinan Town, Shanghai, 201399, China
    Tumour Biol 34:2551-6. 2013
    ..NAD(P)H:quinone oxidoreductase 1 (NQO1) is a cytosolic enzyme that catalyzes the two-electron reduction of quinoid compounds into hydroquinones...
  8. ncbi The expression of NAD(P)H:quinone oxidoreductase 1 is high in human adipose tissue, reduced by weight loss, and correlates with adiposity, insulin sensitivity, and markers of liver dysfunction
    Jenny Palming
    Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecular and Clinical Medicine, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    J Clin Endocrinol Metab 92:2346-52. 2007
    We have previously identified nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1 (NQO1), an enzyme involved in the protection against oxidative stress, as a gene predominantly expressed in human adipocytes...
  9. doi Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans
    Sang Yong Eom
    Department of Preventive Medicine, College of Medicine, Chungbuk National University, 12 Gaeshin Dong, Heungdok gu, Cheongju, Chungbuk, 361 763, Republic of Korea
    Cancer Causes Control 20:137-45. 2009
    We investigated the association of genetic polymorphisms of NQO1, ALDH2, CYP2E1, and the combined genotype of these genes on lung cancer risk, and also evaluated the association after stratification by cumulative smoking amounts and ..
  10. pmc Association of human NAD(P)H:quinone oxidoreductase 1 (NQO1) polymorphism with development of acute lung injury
    Anita J Reddy
    Duke University Medical Center, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Durham, NC, USA
    J Cell Mol Med 13:1784-91. 2009
    ..study, we characterized functional promoter single nucleotide polymorphisms (SNPs) in the phase II antioxidant gene NQO1 (NAD(P)H:quinone oxidoreductase1) to evaluate its role in susceptibility to ALI...
  11. doi Polymorphism of xenobiotic-metabolizing genes and breast cancer susceptibility in North Indian women
    Virendra Singh
    Indian Institute of Toxicology Research Council of Scientific and Industrial Research, Lucknow, India
    Genet Test Mol Biomarkers 15:343-9. 2011
    NAD(P)H:quinone oxidoreductase 1 (NQO1) and cytochrome P450 1A2 (CYP1A2) are involved in the metabolism of estrogens. Genetic polymorphisms in these genes may lead to interindividual variation in breast cancer susceptibility...
  12. pmc NAD(P)H:quinone oxidoreductase 1 (NQO1) competes with 20S proteasome for binding with C/EBPα leading to its stabilization and protection against radiation-induced myeloproliferative disease
    Junkang Xu
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 287:41608-18. 2012
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that protects cells against radiation and chemical-induced oxidative stress. Disruption of NQO1 gene in mice leads to increased susceptibility to myeloproliferative disease...
  13. ncbi [Studies of the genes related to lung cancer susceptibility in Nanjing Han population, China]
    Ge Yu Liang
    School of Public Health, Southeast University, Nanjing 210009, China
    Yi Chuan 26:584-8. 2004
    ..The polymorphisms of CYP1A1, CYP2E1, GSTM1, GSTT1, GSTP1, mEH and NQO1 genes were analyzed by PCRjRFLP assay...
  14. doi Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2
    Yanlin Zhang
    Research Center of Occupational Medicine, Third Hospital of Peking University, Peking, PR China
    Free Radic Res 42:362-71. 2008
    ..The results showed that CHL could induce HO-1 and NQO1 expression in human umbilical vein endothelial cell (HUVEC) in a time- and dose-dependent manner and protect them ..
  15. doi C609T polymorphism of NAD(P)H quinone oxidoreductase 1 as a predictive biomarker for response to amrubicin
    Osamu Takakuwa
    Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Mizuho ku, Nagoya, Japan
    J Thorac Oncol 6:1826-32. 2011
    ..NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme known to metabolize amrubicinol, the active metabolite of amrubicin, to an inactive compound...
  16. doi Activation of NAD(P)H:quinone oxidoreductase 1 prevents arterial restenosis by suppressing vascular smooth muscle cell proliferation
    Sun Yee Kim
    Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea
    Circ Res 104:842-50. 2009
    ..The activation of AMPK in VSMCs by betaL is mediated by LKB1 in the presence of NQO1. Taken together, these results show that betaL inhibits VSMCs proliferation via the NQO1 and LKB1-dependent ..
  17. ncbi Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer
    Elise M J van der Logt
    Department of Gastroenterology, University Medical Centre, St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Mutat Res 593:39-49. 2006
    ..whether polymorphisms in the genes coding for microsomal epoxide hydrolase (EPHX1), NAD(P)H:quinone oxidoreductase (NQO1), cytochrome P450 2E1 (CYP2E1) and alcohol dehydrogenase (ADH3) predispose to the development of CRC...
  18. pmc NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of the tumour suppressor p33(ING1b)
    Marco Garate
    Department of Dermatology and Skin Science, Jack Bell Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6G 3Z6, Canada
    EMBO Rep 9:576-81. 2008
    ..We found that p33(ING1b) is degraded in the 20S proteasome and that NAD(P)H quinone oxidoreductase 1 (NQO1), an oxidoreductase previously shown to modulate the degradation of p53 in the 20S proteasome, inhibits the ..
  19. pmc HIV-1 gp120 induces antioxidant response element-mediated expression in primary astrocytes: role in HIV associated neurocognitive disorder
    Pichili Vijaya Bhaskar Reddy
    Department of Immunology, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA
    Neurochem Int 61:807-14. 2012
    ..with stimulation of key antioxidant defensive enzymes Hemoxygenase (HO-1) and NAD(P)H dehydrogenase quinone1 (Nqo1)...
  20. ncbi A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer
    Christoph Sachse
    Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Carcinogenesis 23:1839-49. 2002
    ..and GSTT1), sulfotransferase (SULT1A1 and SULT1A2), N-acetyl transferase 2 (NAT2), NAD(P)H:quinone oxidoreductase (NQO1), methylenetetrahydrofolate reductase (MTHFR), and microsomal epoxide hydrolase (EPHX1) genes...
  21. ncbi Influence of polymorphism in DNA repair and defence genes on p53 mutations in bladder tumours
    Charlotta Ryk
    Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden
    Cancer Lett 241:142-9. 2006
    ..XRCC1(Arg3999Gln), XRCC3(Thr241Met), NBS1(Glu185Gln), cyclin D1(Pro241Pro), MTHFR(Ala222Val and Glu429Ala) and NQO1(Arg139Trp and Pro187Ser). We found increased risk for p53 mutation among cyclin D1 variant allele homozygotes (OR 2...
  22. ncbi No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood
    O P Kristiansen
    Steno Diabetes Center, Gentofte, Denmark
    Hum Mutat 14:67-70. 1999
    ..cM region mapping to 16q22-q24 (D16S515-D16S520), where also the gene encoding NAD(P)H: quinone oxidoreductase (NQO1) maps. Data has suggested association of a polymorphism (P187S) in the NQO1 gene and type 1 diabetes...
  23. ncbi Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)
    J V Skelly
    CRC Biomolecular Structure Unit and CRC Centre for Cancer Therapeutics, The Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
    J Med Chem 42:4325-30. 1999
    ..Some of the differences are a consequence of the shift in position for the FAD molecule and may contribute to the observed differences in rate of the two-electron reduction of CB1954...
  24. ncbi Interaction of the molecular chaperone Hsp70 with human NAD(P)H:quinone oxidoreductase 1
    Adil Anwar
    Department of Pharmaceutical Sciences, School of Pharmacy and Cancer Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:14060-7. 2002
    NAD(P)H:quinone oxidoreductase 1 (EC; DT-Diaphorase, NQO1) is predominantly a cytosolic flavoenzyme that catalyzes a two-electron reduction...
  25. ncbi Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia
    Maja Krajinovic
    Service d hématologie oncologie, Centre de Recherche, Hopital Sainte Justine, Montreal, Quebec, H3T 1C5 Canada
    Clin Cancer Res 8:802-10. 2002
    ..Similarly, differential capacity of ALL patients to process carcinogens and chemotherapeutic drugs could both modify an individual's risk of recurrent malignancy and response to therapy...
  26. ncbi The NQO1 C609T polymorphism and risk of lung cancer: a meta-analysis
    Yin Liu
    Department of Respiratory Medicine, Drum Tower Hospital, Nanjing University Medical School, Nanjing, China
    Asian Pac J Cancer Prev 12:3091-5. 2011
    NAD(P)H: quinone oxidoreductase 1 (NQO1) is a cytosolic flavoprotein that catalyzes the two- electron reduction of quinoid compounds into hydroquinones...
  27. pmc The protein level of PGC-1α, a key metabolic regulator, is controlled by NADH-NQO1
    Yaarit Adamovich
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Mol Cell Biol 33:2603-13. 2013
    ..We further demonstrate that PGC-1α degradation is inhibited by NQO1, a 20S gatekeeper protein. NQO1 binds and protects PGC-1α from degradation in an NADH-dependent manner...
  28. ncbi NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T gene polymorphism association with digestive tract cancer: a meta-analysis
    Cheng Lin Zhu
    Department of General Surgery, Anhui Provincial Hospital Affiliated with Anhui Medical University, Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, Hefei, Anhui, China
    Asian Pac J Cancer Prev 14:2349-54. 2013
    NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T gene polymorphisms have been reported to influence the risk for digestive tract cancer (DTC) in many studies; however, the results remain controversial and ambiguous...
  29. pmc NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans
    Judith A Voynow
    Division of Pediatric Pulmonary Medicine, Department of Pediatrics, Duke University Medical Center, Box 2994, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 41:107-13. 2009
    One host susceptibility factor for ozone identified in epidemiologic studies is NAD(P)H quinone oxidoreductase 1 (NQO1)...
  30. doi A functional NQO1 609C>T polymorphism and risk of hepatocellular carcinoma in a Chinese population
    Fei Liu
    Division of Liver Transplantation, Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, 37 Guo Xue Road, Chengdu, 610041, Sichuan Province, China
    Tumour Biol 34:47-53. 2013
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a cytosolic flavoprotein that catalyzes the two-electron reduction of quinoid compounds into hydroquinones, thus protecting cells from oxidative damage...
  31. doi Genetic polymorphisms of NQO1, CYP1A1 and TPMT and susceptibility to acute lymphoblastic leukemia in a Tunisian population
    Slah Ouerhani
    Laboratory of Molecular and Cellular Haematology, Pasteur Institute of Tunis, University of Tunis El Manar, Tunis, Tunisia
    Mol Biol Rep 40:1307-14. 2013
    ..low-risk genetic polymorphisms such as variants within cytochrome P450A1 (CYP1A1), NADPH: quinone oxidoreductase (NQO1) and Thiopurine methyltransferase (TPMT) genes...
  32. doi Association between polymorphisms in apoptotic genes and susceptibility for developing breast cancer in Syrian women
    Bassam Lajin
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
    Breast Cancer Res Treat 138:611-9. 2013
    ..The NQO1 was shown to act as a p53 stabilizer and was suggested to play an important role in the protection against ..
  33. ncbi Polymorphisms in the NAD(P)H: quinone oxidoreductase gene and small cell lung cancer risk in a UK population
    S J Lewis
    School of Epidemiology and Health Sciences, Medical School, University of Manchester, Oxford Road, Manchester M139PT, UK
    Lung Cancer 34:177-83. 2001
    NAD(P)H: quinone oxidoreductase (NQO1) protects the cell against cytotoxicity by reducing the concentration of free quinone available for single electron reduction...
  34. ncbi Clinical significance of a NAD(P)H: quinone oxidoreductase 1 polymorphism in patients with disseminated peritoneal cancer receiving intraperitoneal hyperthermic chemotherapy with mitomycin C
    Ronald A Fleming
    Section on Hematology Oncology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Pharmacogenetics 12:31-7. 2002
    Recent data indicate that NAD(P)H: quinone oxidoreductase 1 (NQO1) is important in the activation of mitomycin C. A polymorphism in human NQO1 (609C>T) is associated with diminished NQO1 activity...
  35. ncbi NQO1 T allele associated with decreased risk of later age at diagnosis lung cancer among never smokers: results from a population-based study
    C H Bock
    Population Studies and Prevention Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
    Carcinogenesis 26:381-6. 2005
    The NAD(P)H:quinone oxidoreductase 1 gene, NQO1, contains a C to T transition at amino acid codon 187, which results in very low enzymatic activity...
  36. ncbi No associations between Parkinson's disease and polymorphisms of the quinone oxidoreductase (NQO1, NQO2) genes
    Starlyn Okada
    Department of Environmental and Occupational Health Sciences, University of Washington, Box 357234, Seattle, WA 98195 7234, USA
    Neurosci Lett 375:178-80. 2005
    ..The quinone oxidoreductases, nicotinamide adenine dinucleotide (phosphate) (NAD[P]H): quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH): quinone oxidoreductase 2 (NQO2) detoxify quinones and quinonoid compounds...
  37. doi Involvement of NAD(P)H:quinone oxidoreductase 1 and superoxide dismutase polymorphisms in ulcerative colitis
    Toshihito Kosaka
    Department of Internal Medicine, Second Teaching Hospital Fujita Health University School of Medicine, Nagoya 454 8509, Japan
    DNA Cell Biol 28:625-31. 2009
    ..The genes superoxide dismutase (SOD2) and NAD(P)H:quinone oxidoreductase 1 (NQO1) are involved in inflammation and oxidative stress...
  38. doi Oxidative stress in tardive dyskinesia: genetic association study and meta-analysis of NADPH quinine oxidoreductase 1 (NQO1) and Superoxide dismutase 2 (SOD2, MnSOD) genes
    Clement C Zai
    Neurogenetics Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, Canada M5T 1R8
    Prog Neuropsychopharmacol Biol Psychiatry 34:50-6. 2010
    ..Pae et al. (2004) originally reported a significant association between TD and the NADPH quinine oxidoreductase 1 (NQO1) gene Pro187Ser (C609T, rs1800566) polymorphism in Korean schizophrenia patients; however, subsequent studies have ..
  39. ncbi The expression of NAD(P)H:quinone oxidoreductase 1 is increased along with NF-kappaB p105/p50 in human cutaneous melanomas
    Yabin Cheng
    Department of Dermatology and Skin Science, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada
    Oncol Rep 23:973-9. 2010
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a key enzyme involved in metabolism of quinones and may perform multiple functions within the cell...
  40. doi Detection of quinone oxidoreductase 1 (NQO1) single-nucleotide polymorphisms (SNP) related to benzene metabolism in immortalized B lymphocytes from a Chinese Han population
    Juan Zhang
    Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, People s Republic of China
    J Toxicol Environ Health A 73:490-8. 2010
    ..Quinone oxidoreductase 1 (NQO1) is an important detoxification enzyme involved in the catabolism of 1,4-benzoquinone (1,4-BQ), a benzene ..
  41. ncbi Association between exposure-relevant polymorphisms in CYP1B1, EPHX1, NQO1, GSTM1, GSTP1 and GSTT1 and risk of colorectal cancer in a Czech population
    Ivona Hlavata
    Toxicogenomics Unit, National Institute of Public Health, 100 42 Prague, Czech Republic
    Oncol Rep 24:1347-53. 2010
    ..These results provide further evidence that interaction between metabolic gene variants contributes to colorectal carcinogenesis...
  42. doi Contribution of NAD(P)H quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and risk of colorectal adenoma and colorectal cancer in Caucasians: a meta-analysis
    Jing Chen
    Department of Cadre ward, General Hospital of Chengdu Military Region, China
    Arch Med Res 43:58-66. 2012
    The effects of polymorphism of NAD(P)H quinone oxidoreductase 1 (NQO1 Pro187Ser, rs1800566) on the risks of colorectal adenoma and cancer have been widely studied and results remain controversial...
  43. pmc NAD(P)H:quinone oxidoreductase 1 (NQO1) localizes to the mitotic spindle in human cells
    David Siegel
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
    PLoS ONE 7:e44861. 2012
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is an FAD containing quinone reductase that catalyzes the 2-electron reduction of a broad range of quinones...
  44. pmc Up-regulation of NAD(P)H quinone oxidoreductase 1 during human liver injury
    Lauren M Aleksunes
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 North Eagleville Road, Unit 3092, Storrs, CT 06269 3092, USA
    World J Gastroenterol 12:1937-40. 2006
    To investigate the expression and activity of NAD(P)H quinone oxidoreductase 1 (NQO1) in human liver specimens obtained from patients with liver damage due to acetaminophen (APAP) overdose or primary biliary cirrhosis (PBC).
  45. ncbi Investigation of NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism in prostate cancer
    H Arzu Ergen
    Institute of Experimental Medicine, Department of Molecular Medicine, Istanbul University, Capa Istanbul, Turkey
    Anticancer Res 27:4107-10. 2007
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a part of the antioxidant defense system...
  46. doi Inflammatory cytokines suppress NAD(P)H:quinone oxidoreductase-1 and induce oxidative stress in cholangiocarcinoma cells
    Auemduan Prawan
    Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
    J Cancer Res Clin Oncol 135:515-22. 2009
    The aim of this study was to evaluate the effect of inflammation on NAD(P)H: quinone oxidoreductase-1 (NQO1), the xenobiotic metabolizing and antioxidant enzyme protecting cells against electrophiles and reactive oxygen species in biliary ..
  47. ncbi Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues
    Ling Ming Tseng
    Department of Surgery, Taipei Veterans General Hospital and National Yang Ming University, Taiwan 112, ROC
    Oncol Rep 21:1169-74. 2009
    The NAD(P)H:quinone oxidoreductase 1 (NQO1) enzyme is implicated in protection against oxidative stress and carcinogenesis...
  48. pmc NAD(P)H quinone-oxydoreductase 1 protects eukaryotic translation initiation factor 4GI from degradation by the proteasome
    Amandine Alard
    INSERM U858, Institut de Médecine Moléculaire de Rangueil I2MR, Département Cancer, Equipe 16, BP 84225, 31432 Toulouse Cedex 4, France
    Mol Cell Biol 30:1097-105. 2010
    ..Here, we show that eIF4GI exists in a complex with NAD(P)H quinone-oxydoreductase 1 (NQO1) in cell extracts...
  49. pmc NAD(P)H quinone oxidoreductase protects TAp63gamma from proteasomal degradation and regulates TAp63gamma-dependent growth arrest
    Oshrat Hershkovitz Rokah
    Felsenstein Medical Research Center, Beilinson Hospital, Sackler School of Medicine, Tel Aviv University, Petah Tikva, Israel
    PLoS ONE 5:e11401. 2010
    ..NAD(P)H quinone oxidoreductase (NQO1) has recently been shown to interact with and inhibit the degradation of p53...
  50. doi Differentiation-dependent expression of NADP(H):quinone oxidoreductase-1 via NF-E2 related factor-2 activation in human epidermal keratinocytes
    Mei Shan Piao
    Department of Dermatology, Chonnam National University Medical School, Gwangju, Republic of Korea
    J Dermatol Sci 62:147-53. 2011
    ..NADP(H):quinone oxidoreductase-1 (NQO-1) is known for its protective role in skin carcinogenesis, but the expression of NQO-1 during keratinocyte (KC) differentiation has not been studied...
  51. doi Genetic association of Glutathione peroxidase-1 (GPx-1) and NAD(P)H:Quinone Oxidoreductase 1(NQO1) variants and their association of CAD in patients with type-2 diabetes
    Tharmarajan Ramprasath
    Department of Biochemistry, Center for Excellence in Genomic Sciences, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamilnadu, India
    Mol Cell Biochem 361:143-50. 2012
    ..Glutathione peroxidase-1 (GPx-1) and NAD(P)H: quinone oxidoreductase (NQO1) are known for its broad range of detoxification...
  52. ncbi Increased levels of NAD(P)H: quinone oxidoreductase 1 (NQO1) in pancreatic tissues from smokers and pancreatic adenocarcinomas: A potential biomarker of early damage in the pancreas
    B D Lyn-Cook
    Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, Arizona, USA
    Cell Biol Toxicol 22:73-80. 2006
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is elevated in several human tumors...
  53. doi The influence of fruit and vegetable consumption and genetic variation on NAD(P)H:quinone oxidoreductase (NQO1) phenotype in an endoscopy-based population
    Mariken J Tijhuis
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Nutr Cancer 60:204-15. 2008
    NAD(P)H:quinone oxidoreductase (NQO1) is an inducible detoxification enzyme relevant for colorectal cancer biochemoprevention...
  54. ncbi Analysis of NQO1 polymorphisms and p53 protein expression in patients with hepatocellular carcinoma
    Mei Miao Chiu
    Institute of Anatomy and Cell Biology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Histol Histopathol 24:1223-32. 2009
    NAD(P)H: quinone oxidoreductase 1 (NQO1), a cytosolic enzyme which catalyzes the two-electron reduction of quinone compounds, has been suggested to prevent the generation of semiquinone free radicals and reactive oxygen species, thus ..
  55. doi Investigation of NQO1 genetic polymorphism, NQO1 gene expression and PAH-DNA adducts in ESCC. A case-control study from Iran
    H A Marjani
    National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
    Genet Mol Res 9:239-49. 2010
    We evaluated the effect of NQO1 genetic variation on PAH-DNA adducts in esophageal squamous cell carcinoma (ESCC) in northeast Iran. Golestan Province in northeast of Iran has one of the highest esophageal cancer incidences in the world...
  56. ncbi No association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and risk of hepatocellular carcinoma development in Turkish subjects
    Hikmet Akkiz
    Department of Gastroenterology, Faculty of Medicine, Cukurova University, Adana, Turkey
    Asian Pac J Cancer Prev 11:1051-8. 2010
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a cytosolic enzyme that catalyzes the two-electron reduction of numerous quinoid compounds into their less toxic form, thus NQO1 protecting cells against oxidative stress...
  57. doi Role of NQO1 609C>T and NQO2-3423G>A polymorphisms in susceptibility to gastric cancer in Kashmir valley
    Manzoor Ahmad Malik
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
    DNA Cell Biol 30:297-303. 2011
    NADPH: quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside: quinone oxidoreductase 2 (NQO2) are cytosolic enzymes that catalyze reductive activation of carcinogens from cigarette smoke, such as nitrosamines and heterocyclic ..
  58. ncbi Genetic polymorphisms of NAD(P)H quinone oxidoreductase, CYP1A1 and microsomal epoxide hydrolase and lung cancer risk in Nanjing, China
    L Yin
    School of Public Health, Southeast University, Nanjing, PR China
    Lung Cancer 33:133-41. 2001
    ..Genetic polymorphisms of NAD(P)H quinone oxidoreductase (NQO1), cytochrome P4501A1 (CYP1A1) and microsomal epoxide hydrolase (HYL1) have been associated with increased lung ..
  59. ncbi Profile of polymorphisms of drug-metabolising enzymes and the risk of therapy-related leukaemia
    Pascual Bolufer
    Laboratory of Molecular Biology Medical Biopathology, Hospital Universitario La Fe, Valencia, Spain
    Br J Haematol 136:590-6. 2007
    ..of genetic polymorphisms of CYP1A1*2A(T6235C), CYP2E1*5B(C-1019T), CYP3A4*1B(A-290G), del{GSTT1}, del{GSTM1}, NQO1*2(C609T), MTHFR(C677T) and TYMS 2R/3R in 78 t-AML/t-MDS and 458 normal individuals (control group, CG) using real-..
  60. ncbi Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer
    Chi Chen Hong
    Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 16:1784-94. 2007
    ..Using unconditional logistic regression, genetic variations in Nrf2 (11108C>T), NQO1 (609C>T), NOS3 (894G>T), and HO-1 [(GT)(n) dinucleotide length polymorphism] were not associated with breast ..
  61. ncbi The highly expressed and inducible endogenous NAD(P)H:quinone oxidoreductase 1 in cardiovascular cells acts as a potential superoxide scavenger
    Hong Zhu
    Division of Biomedical Sciences, Edward Via Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, Research Building II, 1861 Pratt Drive, Blacksburg, VA 24060, USA
    Cardiovasc Toxicol 7:202-11. 2007
    It has recently been demonstrated that purified NAD(P)H:quinone oxidoreductase 1 (NQO1) is able to scavenge superoxide (O2(.-)) though the rate of reaction of O2(...
  62. ncbi Significance of genetic variation at the glutathione S-transferase M1 and NAD(P)H:quinone oxidoreductase 1 detoxification genes in breast cancer development
    Nava Siegelmann-Danieli
    Division of Population Science, Fox Chase Center, Philadelphia, PA, USA
    Oncology 62:39-45. 2002
    ..constitutional genetic variation at the glutathione S-transferase M1 (GSTM1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) detoxification loci in breast cancer development...
  63. ncbi Effect of germ-line genetic variation on breast cancer survival in a population-based study
    Ellen L Goode
    Cancer Research United Kingdom Genetic Epidemiology Group, Strangeways Research Laboratories, University of Cambridge, Wort s Causeway, Cambridge CB1 8RN, United Kingdom
    Cancer Res 62:3052-7. 2002
    ..No effect on survival was seen for polymorphisms in ATM, BRCA1/2, CHK2, KU70, NBS1, RAD51, RAD52, XRCC3, AR, COMT, NQO1, VDR, ADH3, CYP1A1, GSTP1, TGF-beta, or CDH1...
  64. ncbi NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis
    Chun Chao
    Gene Environment Epidemiology Group, IARC, 150, cours Albert Thomas, 69372 Lyon Cedex 08, France
    Cancer Epidemiol Biomarkers Prev 15:979-87. 2006
    NAD(P)H:quinone oxidoreductase 1 (NQO1) is a cytosolic enzyme that catalyzes the two-electron reduction of quinoid compounds into hydroquinones, their less toxic form...
  65. doi NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer
    Rainer Fagerholm
    Department of Obstetrics and Gynecology, Helsinki University Central Hospital, FI 00029 Helsinki, Finland
    Nat Genet 40:844-53. 2008
    b>NQO1 guards against oxidative stress and carcinogenesis and stabilizes p53. We find that a homozygous common missense variant (NQO1(*)2, rs1800566(T), NM_000903.2:c...
  66. ncbi The NAD(P)H:quinone oxidoreductase 1 gene polymorphism and lung cancer: differential susceptibility based on smoking behavior
    L L Xu
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 10:303-9. 2001
    ..of 814 lung cancer patients and 1123 controls to examine the association of the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene polymorphism with lung cancer susceptibility...
  67. ncbi An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: glutathione S-transferase M1 and quinone oxidoreductase 1 and 2
    S Harada
    Institute of Community Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305 8575, Japan
    Biochem Biophys Res Commun 288:887-92. 2001
    ..Phase II detoxification enzymes such as glutathione S-transferase M1 (GSTM1), NAD(P)H:quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) are important as cellular defenses against ..
  68. ncbi Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility
    Noriaki Sunaga
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 11:730-8. 2002
    ..in five genes involved in the metabolism of carcinogens or in the repair of damaged DNA in lung cells, NQO1-Pro187Ser, GSTT1-positive/null, GSTM1-positive/null, CYP1A1-Ile462Val, and OGG1-Ser326Cys, were examined for ..
  69. pmc Association of NQO1 polymorphism with spontaneous breast cancer in two independent populations
    H J Menzel
    Inst f med Biology and Human Genetics, University Innsbruck, Schopfstrasse 41, A 6020 Innsbruck, Austria
    Br J Cancer 90:1989-94. 2004
    ..Two SNPs showed an association with breast cancer: R72P inTP53 and P187S in NQO1. Six SNPs, Q356R and P871L in BRCA1, N372H in BRCA2, C112R (E4) and R158C (E2) in ApoE and C825T in GNB3, did not ..
  70. ncbi Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina
    Lee E Moore
    School of Public Health, Arsenic Health Effects Research Program, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
    Cancer Lett 211:199-207. 2004
    ..GST) enzymes (M1, T1), methylenetetrahydrofolate (MTHFR) 677 and 1298, and the NAD(P)H:quinone oxidoreductase (NQO1) polymorphisms in a population-based bladder cancer case-control study in Argentina...
  71. ncbi Association of the NAD(P)H: quinone oxidoreductase C609T polymorphism and the risk of cervical cancer in Japanese subjects
    Yoshimitsu Niwa
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Gynecol Oncol 96:423-9. 2005
    In this study, genetic polymorphisms, NQO1 C609T, GSTM1 positive/null, and GSTT1 positive/null, were examined with reference to cervical cancer risk in a population-based incident case-control study in Japanese.
  72. ncbi Association between Helicobacter pylori seropositivity and NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism observed in outpatients and health checkup examinees
    Yasuyuki Goto
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Gastric Cancer 8:12-7. 2005
    ..This study investigated the associations of functional polymorphisms of the NQO1, GSTM1, and GSTT1 genes of detoxification enzymes, with the seropositivity, as well as with pepsinogen levels, as ..
  73. ncbi 20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1
    Gad Asher
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Mol Cell 17:645-55. 2005
    ..We describe here an alternative pathway for ODC degradation that is regulated by NAD(P)H quinone oxidoreductase 1 (NQO1). We show that NQO1 binds and stabilizes ODC...
  74. ncbi Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway
    Halla Skuladottir
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark
    Lung Cancer 48:187-99. 2005
    ..characteristics, and polymorphisms in following genotypes were determined GSTM1, GSTM3, GSTP1, GSTT1, GPX1, MPO, NQO1 and NAT2. Based on the literature, the alleles of the genotypes were categorised as high- or low-risk alleles...
  75. ncbi Role of NQO1 polymorphisms as risk factors for squamous cell carcinoma of the head and neck
    Asher Begleiter
    Manitoba Institute of Cell Biology, CancerCare Manitoba, 675 McDermot Avenue, Winnipeg, Man, Canada
    Oral Oncol 41:927-33. 2005
    A case: control study was carried out to determine if inactivating polymorphisms of the NQO1 gene at bases 609 and 465 are associated with altered risk of developing squamous cell carcinoma of the head and neck (SCCHN)...
  76. ncbi Polymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in Chinese patients with non-small cell lung cancers: relationship with aberrant promoter methylation of the CDKN2A and RARB genes
    Eunice C Chan
    University Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong SAR, China
    Cancer Genet Cytogenet 162:10-20. 2005
    ..repair cross-complementing group 1 (XRCC1) (nucleotides 26304 C/T; 28152 G/A), and NADPH quinine oxidoreductase (NQO1) (nucleotide 609 C/T) genes in 75 Chinese patients with non-small cell lung cancer (NSCLC) were characterized with ..
  77. ncbi Role of NQO1C609T and EPHX1 gene polymorphisms in the association of smoking and alcohol with sporadic distal colorectal adenomas: results from the UKFSS Study
    Panagiota N Mitrou
    Dunn Human Nutrition Unit, MRC Wellcome Trust Building, Hills Road, Cambridge CB2 2XY, UK
    Carcinogenesis 28:875-82. 2007
    NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic ..
  78. ncbi A NAD(P)H:quinone oxidoreductase 1 polymorphism is a risk factor for human colon cancer
    Asher Begleiter
    Manitoba Institute of Cell Biology, 675 McDermot Avenue, Winnipeg, Manitoba, Canada MB R3E 0V9
    Cancer Epidemiol Biomarkers Prev 15:2422-6. 2006
    ..We have shown that the phase II detoxifying enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1) contributes to the inhibition of carcinogen-induced colon cancer in rats at both the initiation and postinitiation ..
  79. ncbi Polymorphisms in NQO1 and the clinical course of urinary bladder neoplasms
    Somali Sanyal
    Division of Clinical Cancer Epidemiology, Department of Oncology Pathology, Karolinska Institute, Stockholm, Sweden
    Scand J Urol Nephrol 41:182-90. 2007
    ..This study was conducted to determine the effect of polymorphisms in the xenobiotic metabolic genes on the disease course and clinical outcomes of urinary bladder neoplasms...
  80. doi Head and neck squamous-cell cancer and its association with polymorphic enzymes of xenobiotic metabolism and repair
    Volker Harth
    BGFA Research Institute of Occupational Medicine, German Social Accident Insurance, University of Bochum, Bochum, Germany
    J Toxicol Environ Health A 71:887-97. 2008
    ..We focused on the impact of 22 sequence variations in CYP1A1, CYP1B1, CYP2E1, ERCC2/XPD, GSTM1, GSTP1, GSTT1, NAT2, NQO1, and XRCC1...
  81. doi Polymorphisms of drug-metabolizing genes and risk of non-Hodgkin lymphoma
    Hee Nam Kim
    Genome Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Jeollanam do, Republic of Korea
    Am J Hematol 84:821-5. 2009
    ..03-1.63), but not T-cell lymphoma. Smoking does not modify the association between these polymorphisms and NHL risk. Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotypes affect the risk of NHL in Korea...
  82. pmc Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)
    Francesc Castro-Giner
    Centre for Research in Environmental Epidemiology, Barcelona, Spain
    Environ Health Perspect 117:1919-24. 2009
    ..Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors...
  83. doi Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer
    Maria Timofeeva
    Department of Epigenomics and Cancer Risk Factors, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Int J Cancer 127:1547-61. 2010
    ..study was conducted to investigate the effects of genetic polymorphisms in the MPO, EPHX1, GSTT1, GSTM1, GSTP1 and NQO1 genes on the risk of early-onset lung cancer development...
  84. doi The NAD(P)H:Quinone Oxidoreductase 1 induces cell cycle progression and proliferation of melanoma cells
    Marco Garate
    Department of Dermatology and Skin Science, Jack Bell Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC Canada
    Free Radic Biol Med 48:1601-9. 2010
    The oxidoreductase NQO1 plays a prominent role in maintaining the cellular homeostasis...
  85. doi Evidence on the association between NQO1 Pro187Ser polymorphism and breast cancer risk in the current studies: a meta-analysis
    Weiguang Yuan
    Institute of Cancer Prevention and Treatment, Harbin Medical University, Nangang District, Harbin, 150081, China
    Breast Cancer Res Treat 125:467-72. 2011
    Several molecular epidemiological studies were conducted in recent years to evaluate the association between NQO1 Pro187Ser polymorphism and breast cancer risk in diverse populations...
  86. pmc Cigarette smoking, genetic polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study
    Hoirun Nisa
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    BMC Cancer 10:274. 2010
    ..Cytochrome P-450 CYP1A1, glutathione-S-transferase (GST) and NAD(P)H:quinone oxidoreductase 1 (NQO1) are important enzymes in the metabolism of tobacco carcinogens, and functional genetic polymorphisms are known for ..
  87. doi Superoxide dismutase and nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase polymorphisms and pancreatic cancer risk
    Beatrice Mohelnikova-Duchonova
    Toxicogenomics Unit, National Institute of Public Health, Prague, Czech Republic
    Pancreas 40:72-8. 2011
    ..dismutase 2 (SOD2 [Ala16Val, rs4880]), SOD3 (Arg231Gly, rs1799895), nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase (NQO1 [Pro187Ser, rs1800566], and NQO2 (Phe47Leu, rs1143684) with pancreatic cancer risk was studied.
  88. doi The C609T inborn polymorphism in NAD(P)H:quinone oxidoreductase 1 is associated with susceptibility to multiple sclerosis and affects the risk of development of the primary progressive form of the disease
    Chrysa Stavropoulou
    Laboratory of Health Physics and Environmental Health, National Center for Scientific Research Demokritos, Athens 15310, Greece
    Free Radic Biol Med 51:713-8. 2011
    ..Inactivating polymorphisms of genes encoding detoxification enzymes, such as NAD(P)H:quinone oxidoreductase 1 (NQO1), could influence susceptibility to MS...
  89. doi Two minor NQO1 and NQO2 alleles predict poor response of breast cancer patients to adjuvant doxorubicin and cyclophosphamide therapy
    David Jamieson
    Northern Institute for Cancer Research, Paul O Gorman Building, Medical School, Newcastle University, Newcastle upon Tyne, UK
    Pharmacogenet Genomics 21:808-19. 2011
    A SNP in the NQO1 gene has been implicated in the response of patients with breast cancer to anthracycline containing regimens...
  90. doi Null association of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility and prognosis of Esophageal cancer in north Indian population and meta-analysis
    Meenakshi Umar
    Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareilly Road, Lucknow 226014, India
    Cancer Epidemiol 36:e373-9. 2012
    NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2), involved in detoxification of environmental carcinogens and activation of chemotherapeutic agents, are supposed to play critical role in carcinogenesis...
  91. pmc The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis
    B Lajin
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
    Br J Cancer 109:1325-37. 2013
    ..The C609T (rs1800566, Pro187Ser) null polymorphism of the NQO1 gene contributes significantly to the variation in enzymatic activity across different populations...
  92. doi Association between NAD(P)H:quinone oxidoreductase 1 rs1800566 polymorphism and risk of bladder cancer
    Hui Zhang
    Department of Urology, Central Hospital of Zhumadian City, Zhumadian City, Henan Province, 463000, China
    Tumour Biol 34:3377-81. 2013
    quinone oxidoreductase 1 (NQO1) rs1800566 (Pro187Ser) is a functional polymorphism which leads to a proline-to-serine amino acid substitution at codon 187 in the NQO1 protein and enzyme activity changes...
  93. pmc NAD(P)H: quinone oxidoreductase 1 and NRH:quinone oxidoreductase 2 polymorphisms in papillary thyroid microcarcinoma: correlation with phenotype
    Junguee Lee
    Research Center for Endocrine and Metabolic Diseases, Chungnam National University Hospital, 282 Munhwa ro, Jung Gu, Daejeon 301 721, Korea
    Yonsei Med J 54:1158-67. 2013
    NAD(P)H:Quinone Oxidoreductase 1 (NQO1) C609T missense variant (NQO1*2) and 29 basepair (bp)-insertion/deletion (I29/D) polymorphism of the NRH:Quinone Oxidoreductase 2 (NQO2) gene promoter have been proposed as predictive and prognostic ..
  94. doi Association between NQO1 Pro187Ser polymorphism and esophageal cancer: a meta-analysis
    Kai Liu
    Department of Thoracic Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo, 315040, Zhejiang Province, China
    Tumour Biol 35:2063-8. 2014
    quinone oxidoreductase 1 (NQO1) is an important enzyme which can catalyze the two-electron reduction of quinoid compounds into hydroquinones...
  95. doi Association of polymorphisms in iNOS and NQO1 with bladder cancer risk in cigarette smokers
    Zhon Min Huang
    Department of Urology, Tung s Taichung Metroharbor Hospital, Taichung County, Taiwan, ROC
    J Chin Med Assoc 77:83-8. 2014
    quinine oxidoreductase (NQO1) plays an important role in the metabolism of several carcinogens contained in cigarettes. Inducible nitric oxide synthase (iNOS) expression had been detected in urinary bladder tumors...
  96. ncbi NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity
    R D Traver
    University of Southern California, School of Pharmacy, Los Angeles, California 90033
    Cancer Res 52:797-802. 1992
    ..Expression of the NAD(P)H:quinone reductase gene (NQO1), which codes for the DTD enzyme, as measured by a polymerase chain reaction amplification technique was then ..
  97. ncbi Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia
    Maja Krajinovic
    Service of Hemato Oncology, Charles Bruneau Cancer Center, Research Center, Sainte Justine Hospital, 3175 Cote Sainte Catherine, Montreal PQ, H3T 1C5, Canada
    Int J Cancer 97:230-6. 2002
    ..The genetic factors underlying the susceptibility to this disease remain elusive. The enzymes CYP2E1, MPO and NQO1 are involved in the biotransformation of a variety of xenobiotics present in organic solvents, tobacco smoke, drugs,..
  98. pmc Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1
    Gad Asher
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 99:13125-30. 2002
    ..We have found another pathway for p53 proteasomal degradation regulated by NAD(P)H quinone oxidoreductase 1 (NQO1). Inhibition of NQO1 activity by dicoumarol induces p53 and p73 proteasomal degradation...
  99. ncbi The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia
    Claire Seedhouse
    Division of Haematology, School of Clinical Laboratory Sciences, University of Nottingham, and Nottingham City Hospital, Nottingham, United Kingdom
    Blood 100:3761-6. 2002
    ..We also assessed the incidence of a functional polymorphism in the NQO1 gene, which is involved in protection of cells from oxidative damage...
  100. ncbi Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children
    Martyn T Smith
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley 94720 7360, USA
    Blood 100:4590-3. 2002
    An inactivating polymorphism at position 609 in the NAD(P)H:quinone oxidoreductase 1 gene (NQO1 C609T) is associated with an increased risk of adult leukemia...
  101. ncbi An association between NQO1 genetic polymorphism and risk of bladder cancer
    Seun Ja Park
    Department of Epidemiology, Unit 189, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mutat Res 536:131-7. 2003
    NAD(P)H:quinone oxidoreductase (NQO1) is a detoxification enzyme that plays a critical role in protecting cells against chemically induced oxidative stress, cytotoxicity, mutagenicity, and carcinogenicity...

Research Grants64

  1. Investigating gene x environment interaction using human exposures to O3 & LPS
    David B Peden; Fiscal Year: 2010
    ..nucleotide polymorphisms (SNPs) for nicotinamide adenine dinucleotide (phosphate) reduced:quinone oxidoreductase (NQO1), with the resulting haplotypes...
  2. Dependency of O-3 Induced Lung Mucus Hypersecretion on NQ01
    W Michael Foster; Fiscal Year: 2010
    ..that a homozygotic genotype for a single nucleotide polymorphism of the quinone oxido-reductase enzyme, NQO1, protects from the acute irritant effects on air flow that occur with exposure to ambient levels of O3...
  3. Michelle Hernandez; Fiscal Year: 2014
    ..4 parts per million (ppm) ozone (O3). GSTM1 and numerous other phase II antioxidant enzymes (NQO1, GSTP1, HO-1) are regulated by the master transcription factor NF-E2- related factor 2 (NRF2)...
  4. Alterations in membrane composition and function eith calorie restriction
    Jon J Ramsey; Fiscal Year: 2011
    ..Also, NAD(P)H-quinone reductase knockout (NQO1 KO) mice will be used to determine if stimulation of the PM redox system is required for life span extension with ..
  5. David Ross; Fiscal Year: 2014
    ..The major mammalian quinone reductases NQO1 and NQO2 are highly polymorphic with a high prevalence of variant alleles resulting in marked phenotypic changes...
  6. Judith A Voynow; Fiscal Year: 2014
    ..Epidemiologic studies support the role of the wild-type NADPH quinone oxidoreductase1 (NQO1) genotype as an asthma susceptibility factor in the presence of ozone...
  7. Rita Ghosh; Fiscal Year: 2014
    ..Our preliminary published results show that level of NADPH: Quinone Oxidoreductase (NQO1), a phase II detoxifying enzyme in the prostate from hormone stimulated rats that develop Prostatic Intraepithelial ..
  8. ANIL KUMAR JAISWAL; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): NAD (P)H:quinone oxidoreductase1 (NQO1) and NRH:quinone oxidoreductase2 (NQO2) are enzymes that generally detoxify quinones, and protect against oxidative stress...
  9. Bhagavatula Moorthy; Fiscal Year: 2016
    ..single nucleotide polymorphisms (SNPs) in the genes for NF-E2-related factor (Nrf2) and/or NADPH quinone reductase (NQO1) contribute to ALI/ARDS by attenuating the expression of pulmonary and hepatic functional phase II anti-oxidant ..
  10. SOLOMON FIIFI OFORI-ACQUAH; Fiscal Year: 2016
    ..We identified NAD(P)H quinone oxido-reductase 1 (NQO1), which is a multi-functional cytoprotective enzyme that scavenges superoxide...
  11. Molecular mechanisms of cytochrome P4501A regulation by hyperoxia
    Bhagavatula Moorthy; Fiscal Year: 2010
    ..2. To test the hypothesis that mice lacking the gene encoding AHR, nrf2 or NQO1 will be more susceptible to hyperoxic lung injury, and that these mice will be rescued by pre-treatment with BNF. 3...
  12. PHOSPHOINOSITIDE SIGNALING TO AND WITHIN THE NUCLEUS
    Richard A Anderson; Fiscal Year: 2012
    ..response mRNAs, including heme oxygenase-1 (HO-1), apolipoprotein E (APOE) and NAD(P)H:quinone oxidoreductase (NQO1)...
  13. ANIL KUMAR JAISWAL; Fiscal Year: 2016
    ..Preliminary studies revealed that quinone oxidoreductases (NQO1 and NQO2) might protect against mammary toxicity, carcinogenicity and metastasis...
  14. ZOLTAN ISTVAN UNGVARI; Fiscal Year: 2014
    ..A major downstream effector of the Nrf2/ARE pathway is the NAD(P)H:quinone oxidoreductase (NQO1) -dependent trans-plasma membrane antioxidant redox system...
  15. Mechanisms of VCP/p97 and Proteasomal pathway in COPD pathogenesis
    Neeraj Vij; Fiscal Year: 2010
    ..We verified that VCP inhibition not only rescues Nrf2 but also enhances proteasomal activity and antioxidant gene, NQO1 (NAD(P)H quinone oxidoreductase 1) expression...
  16. Emma Heart; Fiscal Year: 2016
    ..in the regulation of beta cell redox status and metabolism via NAD (P) H-dependent quinone oxidoreductase, NQO1. The PMET/NQO1 pathway functions to reoxidize glycolytically-derived NADH and to export protons and electrons from ..
  17. Trevor M Penning; Fiscal Year: 2014
    ..PAH o-quinone reductase activity and we will compare their catalytic efficiency and ability to generate ROS with NQO1. The phase II enzymes that remove the PAH- catechols (COMT, SULTs and UGTs) and PAH o-quinones (GSTs) from this ..
  18. PREVENTIVE ONCOLOGY ACADEMIC AWARD
    CHRISTINE SZARKA; Fiscal Year: 1999
    ..These studies are anticipated to lead to future long-term chemoprevention trials. ..
  19. ANIL KUMAR JAISWAL; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Nrf2/ARE-mediated coordinated activation of quinone oxidoreductases (NQO1 and NQO2), and other detoxifying enzyme gene expression, is one mechanism of critical importance in prevention of chemicals ..
  20. Risk Factors for TEL-AML Fusion Genes and Childhood Acute Lymphoblastic Leukemia
    Sameera Ezzat; Fiscal Year: 2009
    ..reductase (MTHFR), and genes that prevent oxidative stress such as NAD(P)H quinone oxidoreductase (NQO1)...
  21. Serrine S Lau; Fiscal Year: 2014
    ..Furthermore, at this therapeutic dose, aTRA induces Nrf2-responsive antioxidant HO-1 and NQO1 genes, as well as nuclear retinoic acid receptors RAR?, RAR?2, RAR?2, and retinoid X receptors RXR? in the kidney...
  22. Liang Jun Yan; Fiscal Year: 2016
    ..of stroke indicate that DLDH activity was lower than in control rats whilst NAD(P)H: quinone oxidoreductase-1 (NQO1) activity increased significantly in the MICA-treated rats...
  23. Patricia Yotnda; Fiscal Year: 2014
    ..In Aim 2, we will force CK-CTLs to overexpress NAD(P)H quinone oxidoreductase-1 (NQO1), an antioxidant that plays a dominant role in the upregulation of anti-apoptotic genes and protects T cells from ..
  24. David A Boothman; Fiscal Year: 2016
    ..In the prior funding period, we discovered that not only were NAD(P)H:quinone oxidoreductase 1 (NQO1) levels elevated 5- to 40-fold in >80% NSCLC tumors vs associated normal tissue, but that catalase levels were ..
  25. Brian M Polster; Fiscal Year: 2016
    ..Clinically safe idebenone, a short chain Coenzyme Q analogue which upon reduction by NQO1 enzyme can shuttle electrons from cytoplasmic NAD(P)H directly to complex III, will be tested for the ability to ..
  26. Exploiting IR inducible NQ01 Levels Using Beta Lapachone
    David Boothman; Fiscal Year: 2003
    ..metabolized in a futile manner by human breast or prostate cancer cells expressing NAD(P)H:quinone oxidoreductase (NQO1) to deplete NAD(P)H and ATP levels and activate a calcium-dependent, non-caspase-mediated, cell death pathway that ..
  27. Li Tang; Fiscal Year: 2015
    ..and inhibit cancer angiogenesis and metastasis;and (6) ITCs potently induce NAD(P)H:quinone oxidoreductase 1 (NQO1), while polymorphisms of NQO1 resulting in low activity strongly predict poor prognosis in breast cancer patients...
  28. Novel Dithiolethiones for Bladder Cancer Prevention
    Yuesheng Zhang; Fiscal Year: 2011
    ..These studies will be performed in rats;the impact of the test compound on three important Phase 2 enzymes (GST, NQO1 and UGT) will be measured;CPDT analogs will be synthesized;various parameters of toxicity and pharmacokinetics of ..
  29. Structure/Function Studies of Quinone Reductase 2
    Zhongtao Zhang; Fiscal Year: 2009
    ..The biological functions of QR2 are still virtually unknown, even though its close homolog, quinone reductase 1 (QR1), is well characterized...
  30. David Ross; Fiscal Year: 2016
    ..the active forms of the BQA Hsp90 inhibitors were their hydroquinone metabolites generated by the quinone reductase NQO1 rather than the parent quinones...
  31. Prevention of Melanoma by Targeting Tyrosinase with Dietary Quercetin
    Randy Burd; Fiscal Year: 2012
    ..of quercetin can lead to anti-tumorgenic events, such as the induction of phase II detoxification enzymes (NQO1 and GST), the stabilization of p53 and expression of its downstream targets (Bax, PUMA, p21 and GADD45)...
  32. NQO1 in Protection Against Benzene Toxicicity
    David Ross; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The homozygous NQO1*2 polymorphism results in a total lack of NQO1 activity due to accelerated degradation of the mutant NQO1*2 protein by the ubiquitin/proteasomal pathway...
  33. Reductase Enzyme-responsive, Self-immolative Nanovehicles
    ROBIN LINDSEY MCCARLEY; Fiscal Year: 2010
    ..that is highly concentrated in the majority of cancer tumor tissues, namely, NAD(P)H:quinone oxidoreductase type 1 (NQO1, DT-diaphorase)...
  34. ROLE OF METABOLISM IN THE BILIARY EXCRETION OF DRUG
    WALTER LEVINE; Fiscal Year: 1990
    ..The focus will be primarily on azoreductase inasmuch as this represents detoxication for DAB and other toxic azo dyes, and the mechanisms for azoreduction ..
  35. Isothiocyanates in the Chemoprevention of Bladder Cancer
    Yuesheng Zhang; Fiscal Year: 2007
    ..Aim 5 will determine the efficacy of an orally administered ITC in inhibiting N-butyl-N- (4-hydroxybutyl)-nitrosamine-induced bladder tumorigenesis in F344 rats. ..
  36. Effects of Ginseng and Ginkgo on Drug Disposition in Man
    Aryeh Hurwitz; Fiscal Year: 2003
    ..1) disposition of probe drugs, 2) cognitive function, and 3) glutathione-S-transferase (GST) and quinone reductase (NQO1), enzymes implicated in chemoprevention of cancer...
  37. ACTIVATION OF 4-HYDROXY TAMOXIFEN TO FORM DNA ADDUCTS
    William Bodell; Fiscal Year: 2000
    ..Direct analysis of the adduct(s) detected in uterine samples of rats treated with TMX will be made by electrospray ionization mass spectrometry. ..
  38. INSECT SPECIES FOR ASSESSMENT OF PROXIDANT TOXICITY
    SAMI AHMAD; Fiscal Year: 1992
    ..oxidized glutathione). In turn, this will enable us to determine whether results obtained using a nonmammalian model species are applicable to studies of the oxidative stress in mammalian systems...
  39. Air Pollution, Inflammation and New Onset Asthma
    Frank Gilliland; Fiscal Year: 2009
    ..NOS3. GSTM1. GSTP1. NQO1, and HO-1 haplotypes and functional variants, and 3) children with chronic airway inflammation as indicated by ..
  40. STRUCTURE AND MECHANISMS OF NAD (P): QUINONE REDUCTASE
    L Amzel; Fiscal Year: 2005
    Quinone reductase (QR1), a cytosolic FAD-containing flavoprotein, is induced as part of the chemoprotective phase II enzymes by many xenobiotics...
  41. Star-PAP and PIPKIalpha in the Regulation of Polyadenylation of Specific mRNAs
    CHRISTY BARLOW; Fiscal Year: 2009
    ..the expression of the stress response mRNA levels of heme oxygenase 1 (HO-1) and NAD(P)H: quinone oxidoreductase (NQO1)...
  42. Y-GLUTAMYLTRANSPEPTIDASE NEGATIVE HEPATOCARCINOGENESIS
    Sambasiva Rao; Fiscal Year: 1990
    ..5) Further characterization of HCC of different degree of differentiation and examine for morphological functional properties after a) developing of transplantable tumors, and b) establishing cell lines...
  43. QUINONE REDUCTASE REGULATION & QUINONE ANTICANCER DRUGS
    Su Shu Pan; Fiscal Year: 1999
    DESCRIPTION: (Applicant's Abstract) The importance of NAD(P)H:quinone oxidoreductase(NQO1) in activating quinone antitumor drugs, causing quinone drug resistance and defending cells against invasive carcinogens has drawn increasing amount ..
  44. MOLECULAR TOXICOLOGY--NMO-1 GENE EXPRESSION
    Daniel Petersen; Fiscal Year: 1992
    ..P450 monooxygenase and a Phase II gene (Nmo-1) encoding an NAD(P)H-dependent menadione oxidoreductase (DT diaphorase)...
  45. Adenocarinoma of the Lung in Women
    Ann Schwartz; Fiscal Year: 2005
    ..2) To determine if genotype at the metabolic enzyme loci CYP1A1, CYP1B1, CYP17, CYP19, GSTM1, GSTP1, COMT, and NQO1 are associated with risk of adenocarcinoma of the lung in women...
  46. STRESS INHIBITORY COMPOUNDS IN ENVIRONMENTAL DISEASE
    Dennis Templeton; Fiscal Year: 1999
    ..Surprisingly, a NAD(P)H-quinone reductase termed NQO1 (DT-diaphorase) was identified as a MEKK1 binding protein...
  47. PRODRUGS TARGETING HYPOXIC TUMOR CELLS
    Alan Sartorelli; Fiscal Year: 2000
    ..A determination of the importance of DNA cross-links to cell death. ..
  48. REDOX INTERACTIONS OF DT DIAPHORASE AND VITAMIN E
    DANIEL LIEBLER; Fiscal Year: 2002
    NAD(P)H:quinone oxidoreductase (NQO1, EC 1.699.2, DT-diaphorase) is a ubiquitous enzyme that carries out 2-electron reduction of numerous quinone substrates and is induced in antioxidant responses...
  49. Azoreductase Mediated Fluorescence Assays
    Hans Johansson; Fiscal Year: 2006
    ..Our azoreductase cuts azo bonds of quencher molecules leading to loss of quenching and thus to generation of fluorescence...
  50. MOLECULAR GENETIC CHANGES IN LEUKEMIA IN INFANTS
    CAROLYN FELIX; Fiscal Year: 2006
    ..An inactivating NQO1 polymorphism confers genetic susceptibility and DNA damage from benzoquinone, which is detoxified by NQO1, may ..
  51. INTERNATIONAL WORKSHOP ON HUMAN CHROMOSOME 5
    JOHN WASMUTH; Fiscal Year: 1993
    ..the genes responsible for: spinal muscular atrophy (SMA), Treacher Collins syndrome (TCOF1), diastrophic dysplasia (DTD), hyperekplexia (STHE), autosomal dominant limb-girdle muscular atrophy (LGMD1) and late onset hereditary deafness...
  52. XENOBIOTICS AND ALLERGIC INFLAMMATION
    Andrew Saxon; Fiscal Year: 2005
    ..Advantage will also be taken of known functional human polymorphisms important oxidative stress pathways (GST and NQO1) to test whether they alter the responses to in vivo nasal DEP challenge...
  53. New Organosulfur Anticarcinogenic Enzyme Inducers
    MARK WELKER; Fiscal Year: 2005
    ..characterize new oxathiolene oxides, dithiolene oxides and aminothiolene oxides, using quinone oxidoreductase (NQO1) inducing ability and three dimensional quantitative structure activity relationships (QSAR) with comparative ..
  54. Synthesis & Evaluation of Lavendamycin Antitumor Agents
    Mohammad Behforouz; Fiscal Year: 2004
    ..Abraham's group for clonogenic survival assays and DNA damage assessment and H.Bealrs group for the NQO1 reductase assays...
  55. Phase II randomized trial of CPT-11 and Mitomycin C
    MIGUEL VILLALONA; Fiscal Year: 2003
    ....
  56. THE ROLE OF NQO1 IN BENZENE-INDUCED HEMATOTOXICITY
    Alison Bauer; Fiscal Year: 2001
    ..In humans, loss of NAD(P)H: quinone oxidoreductase-1 (NQO1) is associated with an increased incidence of benzene poisoning and leukemias...
  57. BACTERIAL GENE DELIVERY VECTORS FOR CANCER THERAPY
    Ivan King; Fiscal Year: 2001
    ..PROPOSED COMMERCIAL APPLICATION: The products discovered from this study, if successful, may be used for the treatment of cancer in patients. ..
  58. Oxidative Stress in Neurons: Role of Aminochrome
    Susan Ledoux; Fiscal Year: 2006
    ..Thus, these specific aims are designed to enhance a central theme in our research which is to determine how different populations of neurons and glial cells and respond to damage to mtDNA caused by reactive oxygen species. ..
  59. Radiation and hyperthermia increases B-lapachone (B-lap) cytotoxicity
    Chang Won Song; Fiscal Year: 2010
    ..Therefore, the cytotoxicity of p-lap is closely related to the activity of cellular NQO1 level...
  60. Molecular Epidemiology of Myelodysplastic Syndromes
    Sara Strom; Fiscal Year: 2002
    ..associated with activation and detoxification of chemical carcinogens (CYP2E1, CYP1A1, CYP1B1, GSTT1, GSTM1, GSTP1, NQO1, and MPO)...
  61. Gene-gene interaction in nasopharyngeal carcinoma
    YIN YAO; Fiscal Year: 2005
    ..and function of 5 CYP genes (CYP1A1, CYP1A2, CYP2D6, CYP2E1, CYP1B1) and a few other polymorphisms (GSTM1, GSTT1, NQO1, NAT1 and NAT2) contribute to the development of NPC and to test for the interaction with high risk genotypes and ..
  62. CELL GROWTH REGULATION VIA THE MEKK/SAPK CASCADE
    Dennis Templeton; Fiscal Year: 2003
    ..activators or inhibitors of the SAPK pathway (depending on concentration) and the two electron quinone reductase NQO1 as critical for transmission of stress signaling pathways upstream of MEKK1...
  63. Biochemical Effects of Disrupting HSP90
    Charles Erlichman; Fiscal Year: 2004
    ..In addition, the role of cytochrome P450 isozymes NQO1 expression in GA resistance will be determined. 2) Determine the mechanism of synergy between GA and cisplatin...
  64. Molecular Epidemiology of t-MDS/AML
    Sara Strom; Fiscal Year: 2007
    ..We hypothesize that specific polymorphisms involved in the metabolism of carcinogens (eg. GSTs, MPO, NQO1, CYPP2E1) or in DMA repair (eg. XRCC1, XRCC3, XPD), as well as epidemiological risk factors( e.g...