NPPB

Summary

Gene Symbol: NPPB
Description: natriuretic peptide B
Alias: BNP, natriuretic peptides B, brain type natriuretic peptide, gamma-brain natriuretic peptide, natriuretic peptide precursor B, natriuretic protein
Species: human

Top Publications

  1. pmc Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
    Christopher Newton-Cheh
    Center for Human Genetic Research, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Genet 41:348-53. 2009
  2. ncbi B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-beta in primary human cardiac fibroblasts: fibrosis, myofibroblast conversion, proliferation, and inflammation
    Ann M Kapoun
    Scios Inc, Fremont, Calif 94555, USA
    Circ Res 94:453-61. 2004
  3. doi NT-proBNP is associated with fibulin-1 in Africans: the SAfrEIC study
    R Kruger
    Hypertension in Africa Research Team HART, North West University, Potchefstroom, South Africa
    Atherosclerosis 222:216-21. 2012
  4. ncbi Impact of body mass and body composition on circulating levels of natriuretic peptides: results from the Dallas Heart Study
    Sandeep R Das
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Circulation 112:2163-8. 2005
  5. doi Does B-type natriuretic peptide predict the new onset of hypertension?
    Hiroyuki Takase
    Department of Internal Medicine, Enshu Hospital, Hamamatsu, Japan
    Hypertens Res 31:1737-44. 2008
  6. doi Natriuretic peptide precursor B gene (TTTC)(n) microsatellite polymorphism in pre-eclampsia
    Gabor Szabo
    1st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary
    Clin Chim Acta 412:1371-5. 2011
  7. doi Comparison of B-type natriuretic peptide and NT proBNP as predictors of survival in patients on high-flux hemodialysis and hemodiafiltration
    Murugan Sivalingam
    Renal Unit, Lister Hospital, Stevenage, Herts, UK
    Hemodial Int 15:359-65. 2011
  8. pmc B-type natriuretic peptide 8-32, which is produced from mature BNP 1-32 by the metalloprotease meprin A, has reduced bioactivity
    Guido Boerrigter
    Cardiorenal Research Laboratory, Guggenheim 915, Mayo Clinic and Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1744-50. 2009
  9. ncbi Plasma brain natriuretic peptide as an independent predictor of in-hospital mortality after acute ischemic stroke
    Kensaku Shibazaki
    Department of Stroke Medicine, Kawasaki Medical School, Kurashiki, Japan
    Intern Med 48:1601-6. 2009
  10. ncbi NT-pro-BNP is associated with inducible myocardial ischemia in mildly symptomatic type 2 diabetic patients
    Jacobijne J Wiersma
    Int J Cardiol 145:295-6. 2010

Research Grants

  1. EXPRESSION AND REGULATION OF ATRIAL NATRIURETIC FACTOR
    David Gardner; Fiscal Year: 2002
  2. ENDOCRINE REGULATION OF CARDIAC HORMONE EXPRESSION
    CHRISTOPHER GLEMBOTSKI; Fiscal Year: 1999
  3. Yasuhiro Ikeda; Fiscal Year: 2014
  4. Polypeptide Hormone Receptor Recognition and Activation
    KENAN GARCIA; Fiscal Year: 2007
  5. Genetic Determinants of Hypertensive Heart Disease in CRI
    Daniel L Dries; Fiscal Year: 2011
  6. FACTORS DETERMINING INTRAOCULAR PRESSURE
    Simon John; Fiscal Year: 2001
  7. Identifiction of the natriuretic peptide receptor kinase
    LINCOLN POTTER; Fiscal Year: 2009
  8. Joseph R Lakowicz; Fiscal Year: 2015
  9. Emmanuel S Buys; Fiscal Year: 2016
  10. Ravi Karra; Fiscal Year: 2016

Detail Information

Publications263 found, 100 shown here

  1. pmc Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
    Christopher Newton-Cheh
    Center for Human Genetic Research, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Genet 41:348-53. 2009
    We examined the association of common variants at the NPPA-NPPB locus with circulating concentrations of the natriuretic peptides, which have blood pressure-lowering properties...
  2. ncbi B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-beta in primary human cardiac fibroblasts: fibrosis, myofibroblast conversion, proliferation, and inflammation
    Ann M Kapoun
    Scios Inc, Fremont, Calif 94555, USA
    Circ Res 94:453-61. 2004
    The natriuretic peptides, including human B-type natriuretic peptide (BNP), have been implicated in the regulation of cardiac remodeling...
  3. doi NT-proBNP is associated with fibulin-1 in Africans: the SAfrEIC study
    R Kruger
    Hypertension in Africa Research Team HART, North West University, Potchefstroom, South Africa
    Atherosclerosis 222:216-21. 2012
    ..Due to an alarming prevalence of hypertensive heart disease in black South Africans, we investigated the associations of NT-proBNP with fibulin-1 and markers of arterial stiffness in Africans and Caucasians...
  4. ncbi Impact of body mass and body composition on circulating levels of natriuretic peptides: results from the Dallas Heart Study
    Sandeep R Das
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Circulation 112:2163-8. 2005
    The association between higher body mass index (BMI) and lower B-type natriuretic peptide (BNP) level is thought to be mediated by expression of the natriuretic peptide clearance receptor (NPR-C) in adipose tissue...
  5. doi Does B-type natriuretic peptide predict the new onset of hypertension?
    Hiroyuki Takase
    Department of Internal Medicine, Enshu Hospital, Hamamatsu, Japan
    Hypertens Res 31:1737-44. 2008
    Increased B-type natriuretic peptide (BNP) expression precedes the development of hypertension in spontaneously hypertensive rats...
  6. doi Natriuretic peptide precursor B gene (TTTC)(n) microsatellite polymorphism in pre-eclampsia
    Gabor Szabo
    1st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary
    Clin Chim Acta 412:1371-5. 2011
    There is a variable tandem repeat polymorphism in the 5'-flanking region of the natriuretic peptide precursor B gene (NPPB)...
  7. doi Comparison of B-type natriuretic peptide and NT proBNP as predictors of survival in patients on high-flux hemodialysis and hemodiafiltration
    Murugan Sivalingam
    Renal Unit, Lister Hospital, Stevenage, Herts, UK
    Hemodial Int 15:359-65. 2011
    ..Serum levels of B-type natriuretic peptide (BNP) and NT proBNP reflect cardiovascular risk but it is unknown which of these peptides is a better predictor of ..
  8. pmc B-type natriuretic peptide 8-32, which is produced from mature BNP 1-32 by the metalloprotease meprin A, has reduced bioactivity
    Guido Boerrigter
    Cardiorenal Research Laboratory, Guggenheim 915, Mayo Clinic and Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1744-50. 2009
    32-amino acid B-type natriuretic peptide (BNP 1-32) plays an important role in cardiovascular homeostasis...
  9. ncbi Plasma brain natriuretic peptide as an independent predictor of in-hospital mortality after acute ischemic stroke
    Kensaku Shibazaki
    Department of Stroke Medicine, Kawasaki Medical School, Kurashiki, Japan
    Intern Med 48:1601-6. 2009
    We investigated whether the plasma brain natriuretic peptide (BNP) level on admission can serve as a biological marker of in-hospital death in patients with acute ischemic stroke.
  10. ncbi NT-pro-BNP is associated with inducible myocardial ischemia in mildly symptomatic type 2 diabetic patients
    Jacobijne J Wiersma
    Int J Cardiol 145:295-6. 2010
    Baseline levels of N-terminal fragment of the brain natriuretic peptide prohormone (NT-pro-BNP) are associated with myocardial ischemia in non-diabetic patients with stable angina pectoris...
  11. ncbi Endothelin-1 and brain natriuretic peptide plasma levels decrease after aortic surgery
    Giuseppe M Raffa
    Department of Cardiac Surgery, IRCCS Istituto Clinico Humanitas, Rozzano MI, Italy
    J Heart Valve Dis 19:724-30. 2010
    Endothelin-1 (ET-1) and B-type natriuretic peptide (BNP) have been reported to be involved in numerous cardiovascular diseases...
  12. pmc B-type natriuretic peptides strongly predict mortality in patients who are treated with long-term dialysis
    Matthew A Roberts
    Department of Nephrology, Austin Health, P O Box 5555, Heidelberg 3084, Australia
    Clin J Am Soc Nephrol 3:1057-65. 2008
    ..Left ventricular abnormalities contribute to cardiovascular disease in patients with chronic kidney disease and may be detected by measurement of B-type natriuretic peptide in serum...
  13. pmc N-terminal proBNP--marker of cardiac dysfunction, fluid overload, or malnutrition in hemodialysis patients?
    John Booth
    Center for Nephrology, Royal Free Hospital, London, UK
    Clin J Am Soc Nephrol 5:1036-40. 2010
    ..However recent reports have suggested that NTproBNP is a marker of volume overload rather than one of cardiac dysfunction. Therefore this study investigated the effect of fluid volume status on NTproBNP...
  14. pmc Early diagnosis of left ventricular diastolic dysfunction in diabetic patients: a possible role for natriuretic peptides
    Silvio Romano
    Cardiology, Department of Internal Medicine and Public Health, University of L Aquila, Italy
    Cardiovasc Diabetol 9:89. 2010
    The aim of the present study was to verify whether BNP might detect pre-clinical diastolic dysfunction (LVDD) in type-2 diabetic patients.
  15. doi Cardiac biomarkers are associated with an increased risk of stroke and death in patients with atrial fibrillation: a Randomized Evaluation of Long-term Anticoagulation Therapy (RE-LY) substudy
    Ziad Hijazi
    Uppsala Clinical Research Center, Dag Hammarskjolds vag 14B, Uppsala, Sweden
    Circulation 125:1605-16. 2012
    ....
  16. pmc NT-proBNP, echocardiographic abnormalities and subclinical coronary artery disease in high risk type 2 diabetic patients
    Henrik Reinhard
    Steno Diabetes Center, Niels Steensenvej 1, DK 2820 Gentofte, Denmark
    Cardiovasc Diabetol 11:19. 2012
    ....
  17. ncbi Utility of B-type natriuretic peptide (BNP) as a screen for left ventricular dysfunction in patients with diabetes
    Victoria Epshteyn
    Department of Medicine, Veteran s Affairs Medical Center, San Diego, California 92161, USA
    Diabetes Care 26:2081-7. 2003
    ..B-type natriuretic peptide (BNP) is secreted from the left ventricle in response to pressure overload and is elevated in both systolic and ..
  18. ncbi Head-to-head comparison of the diagnostic utility of BNP and NT-proBNP in symptomatic and asymptomatic structural heart disease
    Thomas Mueller
    Department of Laboratory Medicine, Konventhospital Barmherzige Brueder, Seilerstaette 2, A 4021 Linz, Austria
    Clin Chim Acta 341:41-8. 2004
    B-type natriuretic peptide (BNP) and the amino-terminal fragment of the BNP prohormone (NT-proBNP) are markers for functional cardiac impairment and are elevated in heart failure (HF)...
  19. ncbi Elevated plasma levels of Nt-proBNP in patients with type 2 diabetes without overt cardiovascular disease
    Martin Magnusson
    Department of Cardiology, University Hospital MAS, Lund University, Sweden
    Diabetes Care 27:1929-35. 2004
    ..This peptide is a split product from the proBNP molecule, and its level in the circulation is not, as the mature BNP peptide, dependent on the peripheral number of BNP receptors...
  20. ncbi Polymorphisms in the B-type natriuretic peptide (BNP) gene are associated with NT-proBNP levels but not with diabetic nephropathy or mortality in type 1 diabetic patients
    Maria Lajer
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Nephrol Dial Transplant 22:3235-9. 2007
    ..Therefore, we investigated the association between two polymorphisms -381T/C and 1551G/A of the BNP gene, plasma NT-proBNP levels and mortality prognosis in 380 type 1 diabetic patients with and without diabetic ..
  21. pmc N-terminal pro-B-type natriuretic peptide and inducible ischemia in the Heart and Soul Study
    Harsimran S Singh
    Division of Cardiology, Columbia University, New York Presbyterian Hospital, New York, New York, USA
    Clin Cardiol 32:447-53. 2009
    B-type natriuretic peptide (BNP) is predictive of inducible ischemia in patients with coronary heart disease (CHD)...
  22. doi NT-proBNP is associated with coronary heart disease risk in healthy older women but fails to enhance prediction beyond established risk factors: results from the British Women's Heart and Health Study
    Naveed Sattar
    Division of Cardiovascular and Medical Sciences, BHF Cardiovascular Research Building, Faculty of Medicine, University of Glasgow, 126 University Place, Scotland, UK
    Atherosclerosis 209:295-9. 2010
    ..Limited evidence suggests NT-proBNP improves prediction of coronary heart disease (CHD) events but further data are needed, especially in people without pre-existing CHD and in women...
  23. ncbi Cardiac troponins and N-terminal pro-brain natriuretic peptide in acute ischemic stroke do not relate to clinical prognosis
    Thorleif Etgen
    Department of Neurology, Technical University of Munich, Germany
    Stroke 36:270-5. 2005
    ..We measured cardiac troponin T (cTnT), cardiac troponin I (cTnI), and N-terminal pro-brain natriuretic peptide (NT-proBNP) at admission in acute ischemic stroke patients without evident myocardial damage...
  24. doi Preoperative, postoperative and 1-year follow-up N-terminal pro-B-type natriuretic peptide levels in severe chronic aortic regurgitation: correlations with echocardiographic findings
    Alessandro Della Corte
    Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, V Monaldi Hospital, Naples, Italy
    Interact Cardiovasc Thorac Surg 7:419-24; discussion 424. 2008
    ..To serially evaluate amino-terminal-pro-BNP (NT-pBNP) serum levels in patients undergoing aortic valve replacement (AVR) for severe chronic aortic ..
  25. doi Raised natriuretic peptides, big-endothelin-1 and improved beta-cell function in type 2 diabetic males with hyperuricaemia
    Michel P Hermans
    Endocrinology and Nutrition Unit, Cliniques Universitaires St Luc, Brussels, Belgium
    Diab Vasc Dis Res 6:190-3. 2009
    ..sensitivity (S), hyperbolic product (BxS), and (BxS) loss rate were determined alongside neurohormones (Nt-proANP, BNP, Big ET-1 and UII). Mean age and diabetes duration were not different between groups...
  26. ncbi Urinary immunoreactive brain natriuretic peptide in patients with renal disease
    K Totsune
    Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai 980 77, Japan
    Regul Pept 63:141-7. 1996
    Urinary immunoreactive brain natriuretic peptide (BNP) was studied by radioimmunoassay in patients with renal disease. Urinary immunoreactive human BNP excretion measured in 11 normal subjects was 3.82 +/- 0.62 pmol/day (mean +/- SEM)...
  27. ncbi B-type natriuretic peptide and renal function in the diagnosis of heart failure: an analysis from the Breathing Not Properly Multinational Study
    Peter A McCullough
    University of California, San Diego Veteran s Affairs Medical Center, San Diego, CA, USA
    Am J Kidney Dis 41:571-9. 2003
    Both B-type natriuretic peptide (BNP) and renal function are prognostic indicators of survival in patients with congestive heart failure (CHF)...
  28. ncbi Prognostic role of brain natriuretic peptide in acute pulmonary embolism
    Nils Kucher
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 107:2545-7. 2003
    ..Rapid, noninvasive, and accurate prognostic assessment with an inexpensive cardiac biomarker is an appealing approach for patients with acute pulmonary embolism (PE)...
  29. ncbi B-type natriuretic peptides and ejection fraction for prognosis after myocardial infarction
    A Mark Richards
    Christchurch Cardioendocrine Research Group, Christchurch School of Medicine and Health Sciences, PO Box 4345, Christchurch, New Zealand
    Circulation 107:2786-92. 2003
    A recent landmark report has demonstrated that plasma B-type natriuretic peptide (BNP) measured in acute coronary syndromes independently predicts mortality, heart failure, and new myocardial infarction...
  30. ncbi Natriuretic peptide system in the human retina
    Raquel Rollin
    Unidad de Investigacion, Departamento de Medicina Interna III, Hospital Clinico San Carlos, Madrid, Spain
    Mol Vis 10:15-22. 2004
    The natriuretic peptide (NP) family includes atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). Natriuretic peptides are known to inhibit vascular cell growth and regulate vessel tone...
  31. ncbi Plasma N-terminal pro-brain natriuretic peptide as a major risk marker for cardiovascular disease in patients with type 2 diabetes and microalbuminuria
    P Gaede
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    Diabetologia 48:156-63. 2005
    ..We examined whether plasma N-terminal probrain natriuretic peptide (NT-proBNP) predicts cardiovascular outcome in patients with type 2 diabetes...
  32. ncbi Plasma concentrations of brain natriuretic peptide in patients with acute ischemic stroke
    Kazuhiko Nakagawa
    Department of Neurosurgery, Tokyo Metropolitan Toshima Hospital, Tokyo, Japan
    Cerebrovasc Dis 19:157-64. 2005
    ..Brain natriuretic peptide (BNP), which is produced in response to such cardiovascular alterations, is expected to play a hemodynamic role...
  33. ncbi Molecular regulation of the brain natriuretic peptide gene
    Margot C LaPointe
    Hypertension and Vascular Research Division, Department of Medicine, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI 48202, USA
    Peptides 26:944-56. 2005
    After brain natriuretic peptide (BNP) was isolated in 1988, rapid progress was made in cloning its cDNA and gene, facilitating studies of tissue-specific expression and molecular regulation of gene expression...
  34. ncbi Increased plasma pro-B-type natriuretic peptide in infants of women with type 1 diabetes
    Karen G Halse
    Department of Clinical Biochemistry, University of Copenhagen, Denmark
    Clin Chem 51:2296-302. 2005
    ..Increased plasma concentrations of B-type natriuretic peptide (BNP) and its precursor (proBNP) are markers of cardiac failure and hypoxia in adults...
  35. pmc Quantitative mass spectral evidence for the absence of circulating brain natriuretic peptide (BNP-32) in severe human heart failure
    Adam M Hawkridge
    W M Keck FT ICR Mass Spectrometry Laboratory and Mayo Proteomics Research Center, Division of Cardiovascular Diseases, Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Proc Natl Acad Sci U S A 102:17442-7. 2005
    C-terminal brain (B-type) natriuretic peptide (BNP)-32 is a widely used clinical biomarker for the diagnosis, prognosis, and treatment of heart failure (HF)...
  36. ncbi Determinants of brain natriuretic peptide levels in patients with lone atrial fibrillation
    Sang Hak Lee
    Cardiology Division, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea
    Circ J 70:100-4. 2006
    Although brain natriuretic peptide (BNP) is increasingly being used for screening and monitoring of congestive heart failure, its utility in patients with lone atrial fibrillation (AF) is unclear.
  37. ncbi Lack of activation of molecular forms of the BNP system in human grade 1 hypertension and relationship to cardiac hypertrophy
    Paola Belluardo
    Cardiorenal Research Laboratory, 200 First St, SW, Rochester, MN 55905, USA
    Am J Physiol Heart Circ Physiol 291:H1529-35. 2006
    ..235, P = 0.012) and HTN grade (beta = 0.218, P = 0.0023). Two forms of BNP were measured in normal subjects and patients with essential HTN...
  38. ncbi Plasma N-terminal pro-B-type natriuretic peptide and mortality in type 2 diabetes
    L Tarnow
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820, Gentofte, Denmark
    Diabetologia 49:2256-62. 2006
    ..Elevated NT-proBNP predicts excess morbidity and mortality in diabetic patients with an elevated urinary albumin excretion rate. This study investigated the prognostic value of NT-proBNP in a cohort of type 2 diabetic patients...
  39. ncbi Genetic variation in the B-type natiuretic peptide pathway affects BNP levels
    David E Lanfear
    Section of Advanced Heart Failure and Cardiac Transplantation, Henry Ford Heart and Vascular Institute, Henry Ford Hospital, 2799 W Grand Boulevard, Cardiology K14, Detroit, MI 48202, USA
    Cardiovasc Drugs Ther 21:55-62. 2007
    The importance of B-type natriuretic peptide (BNP) as a diagnostic and therapeutic modality in cardiovascular disease is well known. BNP levels correlate clinical and physiologic characteristics, as well as outcomes...
  40. ncbi Use of plasma B-type natriuretic peptide level to identify asymptomatic hypertensive patients with abnormal diurnal blood pressure variation profiles: nondippers, extreme dippers, and risers
    Takaaki Nakatsu
    Department of Cardiology, Kagawa ken Saiseikai Hospital, Takamatsu, Japan
    Hypertens Res 30:651-8. 2007
    We examined the relationship between plasma B-type natriuretic peptide (BNP) level and diurnal variability pattern of blood pressure (BP)...
  41. ncbi BNP is a transcriptional target of the short stature homeobox gene SHOX
    Antonio Marchini
    Institute of Human Genetics, Ruprecht Karls University, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Hum Mol Genet 16:3081-7. 2007
    ..Here we identify NPPB encoding the natriuretic peptide, BNP, a well-known cardiac and natriuretic peptide hormone, as a transcriptional ..
  42. pmc Relationships of N-terminal pro-B-natriuretic peptide and cardiac troponin T to left ventricular mass and function and mortality in asymptomatic hemodialysis patients
    Sangeetha Satyan
    Indiana University School of Medicine and Richard L Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
    Am J Kidney Dis 50:1009-19. 2007
    ..with end-stage renal disease, the independent association of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) and cTnT levels in predicting outcomes is unknown...
  43. doi Non-invasive diagnostic and functional evaluation of cardiac involvement in patients with systemic sclerosis
    Michał Ciurzyński
    Department of Internal Medicine and Cardiology, Institute of Dentistry, Medical University of Warsaw, Lindleya 4, 02 005, Warsaw, Poland
    Clin Rheumatol 27:991-7. 2008
    Elevated serum brain natriuretic peptide (BNP) released from myocytes of ventricles upon stretch have been found in patients with isolated right ventricular (RV) pressure overload...
  44. doi B-type natriuretic peptide: a biomarker for the diagnosis and risk stratification of patients with septic shock
    Emad Kandil
    Department of Surgery, SUNY Downstate Medical Center, Campus Box 40, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Arch Surg 143:242-6; discussion 246. 2008
    ..B-type natriuretic peptide (BNP) is a neurohormone released from the ventricles of the heart in response to myocardial dysfunction...
  45. doi BNP or NTproBNP? A clinician's perspective
    Johannes Steiner
    University of South Florida, United States
    Int J Cardiol 129:5-14. 2008
    Existing literature on two natriuretic peptides--B-type natriuretic peptide (BNP) and amino terminal pro-brain natriuretic peptide (NTproBNP)--is overwhelming. Both peptides are acknowledged markers for cardiac dysfunction...
  46. doi Obese and nonobese patients with essential hypertension show similar N-terminal proBNP plasma levels
    Raquel Cortés
    Cardiocirculatory Unit, Research Center, Hospital Universitario La Fe, Valencia, Spain
    Am J Hypertens 21:820-5. 2008
    ..However, the effect of obesity on amino-terminal propeptide of B-type natriuretic peptide (NT-proBNP) levels in hypertensive (HT) patients remains uncertain...
  47. doi Prognostic value of changes in N-terminal pro-brain natriuretic peptide in Val-HeFT (Valsartan Heart Failure Trial)
    Serge Masson
    Department of Cardiovascular Reearch, Istituto Mario Negri, Milan, Italy
    J Am Coll Cardiol 52:997-1003. 2008
    ..This study sought to evaluate the association between changes over time of N-terminal pro-brain natriuretic peptide (NT-proBNP) expressed in different ways and outcome in patients with stable and chronic heart failure (HF)...
  48. doi Predictive role of BNP and NT-proBNP in hemodialysis patients
    Linlin Sun
    Division of Nephrology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China
    Nephron Clin Pract 110:c178-84. 2008
    ..We investigated the role of BNP and NT-proBNP in predicting the outcome and prognostic value in hemodialysis with ESRD patients.
  49. doi Plasma N-terminal pro-B-type natriuretic peptide as a predictor of perioperative and long-term outcome after vascular surgery
    Olaf Schouten
    Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands
    J Vasc Surg 49:435-41; discussion 441-2. 2009
    ..This study assessed the additional prognostic value of NT-proBNP levels as a simple objective risk marker for postoperative cardiac events among vascular surgery patients...
  50. doi N-terminal pro-brain natriuretic peptide independently predicts protein energy wasting and is associated with all-cause mortality in prevalent HD patients
    Qunying Guo
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden
    Am J Nephrol 29:516-23. 2009
    ..We hypothesized that common confounders, such as protein-energy wasting (PEW) and inflammation could modulate this relationship...
  51. pmc N-terminal pro-brain natriuretic peptide levels predict left ventricular systolic function in patients with chronic kidney disease
    Jung Eun Lee
    Division of Nephrology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    J Korean Med Sci 24:S63-8. 2009
    ..812 and 4,740 pg/mL in CKD stage 4, and 0.745 and 15,892 pg/mL in CKD stage 5. The NT-proBNP level was a predictor of LV systolic dysfunction in CKD patients. Optimum cut points should be stratified according to renal function...
  52. doi Comparison of hand-carried ultrasound assessment of the inferior vena cava and N-terminal pro-brain natriuretic peptide for predicting readmission after hospitalization for acute decompensated heart failure
    Sascha N Goonewardena
    University of Chicago Hospitals, Chicago, Illinois 60637, USA
    JACC Cardiovasc Imaging 1:595-601. 2008
    ..assessment with hand-carried ultrasound (HCU) of the inferior vena cava (IVC) with brain natriuretic peptide (BNP) to identify patients with acute decompensated heart failure (ADHF) who will be readmitted or seek emergency ..
  53. doi The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects
    Helene Choquet
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Hum Mol Genet 18:2495-501. 2009
    A recent study reported an association between the brain natriuretic peptide (BNP) promoter T-381C polymorphism (rs198389) and protection against type 2 diabetes (T2D)...
  54. ncbi SNP rs198389 (T-381 C) polymorphism in the B-type natriuretic peptide gene promoter in patients with atherosclerotic renovascular hypertension
    Rafał Poręba
    Department of Internal Medicine, Occupational Diseases and Hypertension, Medical University, Wrocław, Poland
    Pol Arch Med Wewn 119:219-24. 2009
    ..Renovascular hypertension caused by renal artery stenosis (RAS) accounts for 3-5% of all cases of hypertension...
  55. doi B-type natriuretic peptide plasma levels are elevated in subcortical vascular dementia
    Daniel Kondziella
    Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden
    Neuroreport 20:825-7. 2009
    High levels of B-type natriuretic peptide (BNP), a serum marker of congestive heart failure, are associated with an increased risk for cognitive decline. However, no study has yet assessed this marker in different subtypes of dementia...
  56. doi Longitudinal changes in the B-type natriuretic peptide levels in normal pregnancy and postpartum
    Afshan Batool Hameed
    Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of California, Irvine, California, USA
    Clin Cardiol 32:E60-2. 2009
    Normal levels of B-type natriuretic peptide (BNP) are not well established in pregnancy...
  57. doi Serum N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) and homocysteine levels in type 2 diabetic patients with asymptomatic left ventricular diastolic dysfunction
    U Gormus
    Department of Molecular Medicine, Institute of Experimental Medical Research, Istanbul University, Istanbul, Turkey
    Diabetes Res Clin Pract 87:51-6. 2010
    ..The aim of this study was to determine serum NT-proBNP and plasma Hcy levels and to explore the relationship between serum NT-proBNP and plasma Hcy levels in type 2 diabetic patients with and without asymptomatic LVDD...
  58. doi High levels of circulating N-terminal pro-brain natriuretic peptide in patients with hepatitis C
    A Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Viral Hepat 17:851-3. 2010
    ..The increase of NT-proBNP may indicate the presence of a sub-clinical cardiac dysfunction. Further prospective studies quantifying these symptoms in correlation with echocardiography are needed to confirm this association...
  59. doi The effect of renal dysfunction on BNP, NT-proBNP, and their ratio
    Pornpen Srisawasdi
    Division of Clinical Chemistry, Department ofPathology, Boston Medical Center, Boston, MA 02118, USA
    Am J Clin Pathol 133:14-23. 2010
    We examined the effect of renal dysfunction on B-natriuretic peptide (BNP), N-terminal (NT)-proBNP, and their molar ratio at varying severities of cardiac function in 94 Thai patients with chest pain (52 men; 32 women), also measuring ..
  60. doi Amino-terminal pro-B-type natriuretic peptide improves cardiovascular and cerebrovascular risk prediction in the population: the Rotterdam study
    Joost H W Rutten
    Department of Internal Medicine, Room D432, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands
    Hypertension 55:785-91. 2010
    ....
  61. doi B-type natriuretic peptide in patients undergoing orthopaedic surgery: a prospective cohort study
    Tobias Breidthardt
    Department of Internal Medicine, University Hospital Basel, Basel, Switzerland
    Eur J Anaesthesiol 27:690-5. 2010
    ..Postoperative cardiac complications pose a substantial risk to patients undergoing orthopaedic surgery...
  62. doi NT-proBNP levels in systemic sclerosis: association with clinical and laboratory abnormalities
    Rejane Maria Oravec
    Laboratório Weinmann, Porto Alegre, Brazil
    Clin Biochem 43:745-9. 2010
    ..To identify factors related to NT-proBNP levels in systemic sclerosis (SSc)...
  63. pmc Coincidence of moderately elevated N-terminal pro-B-type natriuretic peptide, endothelial progenitor cells deficiency and propensity to exercise-induced myocardial ischemia in stable angina
    Andrzej Surdacki
    2nd Department of Cardiology, Faculty of Medicine, Jagiellonian University, Cracow, Poland
    Dis Markers 28:101-14. 2010
    ....
  64. doi B-type natriuretic peptide is related to cardiac function and prognosis in hospitalized patients with decompensated cirrhosis
    Joana Pimenta
    Department of Internal Medicine, Hospital S Joao, Porto, Portugal
    Liver Int 30:1059-66. 2010
    B-type natriuretic peptide (BNP) concentrations are high in cirrhosis, possibly related to volume status and cirrhotic cardiomyopathy. The prognostic significance of BNP in cirrhosis is unknown.
  65. ncbi Association of plasma B-type natriuretic peptide levels with obesity in a general urban Japanese population: the Suita Study
    Takako Sugisawa
    The Department of Atherosclerosis and Diabetes, National Cardiovascular Center, Osaka, Japan
    Endocr J 57:727-33. 2010
    The inverse association between plasma B-type natriuretic peptide (BNP) levels and body mass index (BMI) has been reported in Western populations...
  66. doi Plasma brain natriuretic peptide predicts death during hospitalization in acute ischaemic stroke and transient ischaemic attack patients with atrial fibrillation
    K Shibazaki
    Department of Stroke Medicine, Kawasaki Medical School, Kurashiki City, Okayama, Japan
    Eur J Neurol 18:165-9. 2011
    ..We investigated whether the plasma brain natriuretic peptide (BNP) level on admission can serve as a biological marker of in-hospital death in acute ischaemic stroke and transient ..
  67. pmc Relationship between natriuretic peptides and echocardiography parameters in patients with poorly regulated type 2 diabetes
    Magnus Dencker
    Unit of Clinical Physiology and Nuclear Medicine, Department of Clinical Sciences, Malmo University Hospital, Malmo, Sweden
    Vasc Health Risk Manag 6:373-82. 2010
    ..Natriuretic peptides brain natriuretic peptide (BNP) and N-terminal prohormone BNP (NT-proBNP) were measured...
  68. doi The clinical use of N-terminal-pro brain natriuretic peptide in elderly patients with mental illness
    Karin Nilsson
    Department of Geriatric Psychiatry, Clinical Science, Lund University Hospital, S 22185 Lund, Sweden
    Clin Biochem 43:1282-6. 2010
    ..Vascular disease plays an important role in cognitive impairment in elderly patients with mental illness...
  69. doi N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) for predicting silent myocardial ischaemia in type 2 diabetes mellitus independent of microalbuminuria
    Kumiko Hamano
    Department of Diabetes and Endocrinology, Shonan Kamakura General Hospital, Yamazaki, Kanagawa, Japan
    Diabetes Metab Res Rev 26:534-9. 2010
    ..We tested the hypothesis that N-terminal pro-brain natriuretic peptide (NT-proBNP) might be a marker for silent myocardial ischaemia in diabetes...
  70. doi Extremely high brain natriuretic peptide does not reflect the severity of heart failure
    Catherine Law
    University of South Florida, Tampa General Hospital, 2 Tampa General Circle, Tampa, FL 33606, USA
    Congest Heart Fail 16:221-5. 2010
    Brain natriuretic peptide (BNP) is important in the diagnosis and management of heart failure (HF). Sometimes, very high BNP levels encountered in clinical settings seem to be out of proportion to the severity of HF...
  71. ncbi Influence of low-grade inflammation on plasma B-type natriuretic peptide levels
    Terumasa Inoue
    Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo
    Intern Med 49:2659-68. 2010
    B-type natriuretic peptide (BNP) is a cardiac hormone. The results of previous in vitro studies suggest that neurohumoral factors, and not only hemodynamic factors, may cause BNP secretion...
  72. pmc The effect of the brain-type natriuretic peptide single-nucleotide polymorphism rs198389 on test characteristics of common assays
    Lisa C Costello-Boerrigter
    Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 86:210-8. 2011
    ..single-nucleotide polymorphism rs198389 in the promoter region of the gene of brain-type natriuretic peptide (BNP) on 3 commonly used BNP assays, clinical phenotype, disease prevalence, overall survival, and diagnostic test ..
  73. doi Impact of obesity on plasma B-type natriuretic peptide levels in Japanese community-based subjects
    Megumi Koizumi
    Division of Cardiovascular Medicine, Department of Internal Medicine, Akita University Faculty of Medicine, 1 1 1 Hondo, Akita City, Akita, 010 8543, Japan
    Heart Vessels 27:287-94. 2012
    The plasma B-type natriuretic peptide (BNP) concentration was recently shown to be inversely correlated with body mass index (BMI)...
  74. doi Steady-state B-type natriuretic peptide levels in patients with atrial fibrillation of various clinical backgrounds
    Tsuneaki Sadanaga
    Division of Cardiology, Ueki Hospital, Iwano 285 29, Ueki, Kumamoto, 861 0136, Japan
    Heart Vessels 27:280-6. 2012
    ..Steady-state B-type natriuretic peptide levels of various clinical backgrounds were presented. Contributions of BNP elevation by clinical variables were somewhat different in different population...
  75. doi N-terminal pro-brain natriuretic Peptide is a more useful predictor of cardiovascular disease risk than C-reactive protein in older men with and without pre-existing cardiovascular disease
    S Goya Wannamethee
    Department of Primary Care and Population Health, UCL Medical School, University College London, Royal Free Campus, Rowland Hill Street, London, United Kingdom
    J Am Coll Cardiol 58:56-64. 2011
    ..We aimed to compare the predictive capabilities of N-terminal pro-brain natriuretic peptide (NT-proBNP) and C-reactive protein (CRP) for risk of cardiovascular disease (CVD) in older men with and without pre-existing CVD...
  76. doi Predicting mortality and hospital admission in patients with COPD: significance of NT pro-BNP, clinical and echocardiographic assessment
    Chris P Gale
    Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, UK
    J Cardiovasc Med (Hagerstown) 12:613-8. 2011
    To quantify the ability of N-terminal pro-brain natriuretic peptide (NT pro-BNP) to predict mortality and hospitalization in patients with chronic obstructive airways disease (COPD).
  77. pmc Relation of obesity to circulating B-type natriuretic peptide concentrations in blacks: the Jackson Heart Study
    Ervin R Fox
    University of Mississippi Medical Center, Division of Cardiovascular Diseases, 2500 N State St, Jackson, MS 39216, USA
    Circulation 124:1021-7. 2011
    Lower plasma B-type natriuretic peptide (BNP) concentrations in obese individuals ("natriuretic handicap") may play a role in the pathogenesis of obesity-related hypertension...
  78. doi Use of brain natriuretic peptide to detect previously unknown left ventricular dysfunction in patients with acute exacerbation of chronic obstructive pulmonary disease
    K Gariani
    Division of General Internal Medicine, Geneva University Hospital, Gabrielle Perret Gentil 6, 1211 Geneva 14, CH
    Swiss Med Wkly 141:w13298. 2011
    ..Their timely identification is challenging as both conditions share similar clinical presentations...
  79. pmc Brain natriuretic peptide predicts functional outcome in ischemic stroke
    Natalia S Rost
    J Philip Kistler Stroke Research Center, Massachusetts General Hospital, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
    Stroke 43:441-5. 2012
    Elevated serum levels of brain natriuretic peptide (BNP) have been associated with cardioembolic stroke and increased poststroke mortality...
  80. doi Amino-terminal pro-brain natriuretic peptide as a predictor of outcome in patients admitted to intensive care. A prospective observational study
    Lina De Geer
    Division of Anaesthesiology, Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden
    Eur J Anaesthesiol 29:275-9. 2012
    ..Amino-terminal pro-brain-type natriuretic peptide is known to predict outcome in patients with heart failure, but its role in an intensive care setting is not yet fully established...
  81. doi Genetic variation in the natriuretic peptide system, circulating natriuretic peptide levels, and blood pressure: an ambulatory blood pressure study
    Jørgen L Jeppesen
    Department of Medicine, Copenhagen University Hospital Glostrup, Denmark
    Am J Hypertens 25:1095-100. 2012
    ..It is unknown if determining an individual's BP by 24-h ambulatory BP measurements (ABPMs) will influence the effect of NP gene variations on BP levels...
  82. ncbi Determination of the B-type natriuretic peptide level as a criterion for abnormalities in Japanese individuals in routine clinical practice: the J-ABS Multi-Center Study (Japan Abnormal BNP Standard)
    Makoto Kawai
    Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Japan
    Intern Med 52:171-7. 2013
    The present study was undertaken to establish a useful range for the B-type natriuretic peptide (BNP) level, with the ultimate goal of determining a cut-off BNP level that will make it possible to identify patients with clinically ..
  83. pmc B-type natriuretic peptides and mortality after stroke: a systematic review and meta-analysis
    Teresa García-Berrocoso
    From the Neurovascular Research Laboratory T G B, D G, A B, J M, Vall d Hebron Institute of Research, Universitat Autonoma de Barcelona, Spain Department of Neurology T E, Kliniken Südostbayern Klinikum Traunstein, Germany Department of Psychiatry and Psychotherapy T E, Technische Universitat Munchen, Germany Department of Cardiology J K J, Odense University, Denmark Stroke Medicine J C S, Lincoln County Hospital, University of Nottingham, UK Department of Stroke Medicine K S, Kawasaki Medical School, Kurashiki City, Okayama, Japan Department of Emergency Medicine A S, School of Medicine, Duzce University, Turkey Department of Neurology X C, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China and Centre for Clinical Brain Sciences W N W, University of Edinburgh, UK
    Neurology 81:1976-85. 2013
    To measure the association of B-type natriuretic peptide (BNP) and N-terminal fragment of BNP (NT-proBNP) with all-cause mortality after stroke, and to evaluate the additional predictive value of BNP/NT-proBNP over clinical information.
  84. ncbi N-terminal pro-brain natriuretic peptide (NT-proBNP) in Type 2 diabetes with left ventricular dysfunction
    Ji Youn Kim
    Division of Endocrinology and Metabolism, Department of Medicine, Seoul, Korea
    Diabetes Res Clin Pract 77:S238-42. 2007
    ..001). NT-proBNP levels significantly differed among three groups according to urinary albumin excretion (P=0.031). These results suggest that NT-proBNP could be used to identify any impairment of left ventricular function in diabetes...
  85. ncbi Hypoxia, via stabilization of the hypoxia-inducible factor HIF-1alpha, is a direct and sufficient stimulus for brain-type natriuretic peptide induction
    Alexander Weidemann
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Krankenhausstr 12, 91054 Erlangen, Germany
    Biochem J 409:233-42. 2008
    b>BNP (brain-type natriuretic peptide) is a cardiac hormone with systemic haemodynamic effects as well as local cytoprotective and antiproliferative properties...
  86. doi B-type natriuretic peptide is predictive of hospitalization in community-dwelling elderly without heart diseases
    Yuji Shimizu
    Department of Medicine and Geriatrics, Kochi Medical School, Nankoku Shi, Kochi, Japan
    Geriatr Gerontol Int 9:148-54. 2009
    To examine prospectively the relationship between plasma B-type natriuretic peptide (BNP) levels in community-dwelling elderly and their hospitalization.
  87. doi Correlates of NT-proBNP concentration in patients with essential hypertension in absence of congestive heart failure
    Keizo Toda
    Department of Pathology, Hyogo Prefecture Amagasaki Hospital, Hyogo, Japan
    J Clin Lab Anal 24:12-6. 2010
    ..Its role in the evaluation of patients with essential hypertension (EHT) is less clear. We examined the relationship between NT-proBNP concentrations and various clinical characteristics in hypertensive patients without HF...
  88. pmc Hyperinsulinemia correlates with low levels of plasma B-type natriuretic peptide in Japanese men irrespective of fat distribution
    Hideaki Nakatsuji
    Department of Metabolic Medicine, Osaka University, Suita, Osaka, Japan
    Cardiovasc Diabetol 11:22. 2012
    B-type natriuretic peptide (BNP), a member of the natriuretic peptide family, is a cardiac-derived secretory hormone with natriuretic, diuretic, and vasorelaxant activities...
  89. ncbi Elevated plasma N-terminal pro-brain natriuretic peptide levels in acute ischemic stroke
    Kenan Iltumur
    Department of Cardiology, Dicle University Medical Faculty, Diyarbakir, Turkey
    Am Heart J 151:1115-22. 2006
    B-type natriuretic peptide (BNP) is a neurohormone secreted mainly in the cardiac ventricles in response to volume expansion and pressure overload...
  90. pmc Plasmatic B-type natriuretic peptide and C-reactive protein in hyperacute stroke as markers of CT-evidence of brain edema
    Pedro J Modrego
    Dept of Neurology Miguel Servet University Hospital Zaragoza Spain
    Int J Med Sci 5:18-23. 2008
    ..The purpose of this work is to investigate whether elevation of these proteins at baseline predicts CT-evidence of brain edema...
  91. doi Effect of beta-blockade and ACE inhibition on B-type natriuretic peptides in stable patients with systolic heart failure
    Jens Rosenberg
    Cardiology Department, Frederiksberg University Hospital, Nordre Fasanvej 57, 2000 Frederiksberg, Denmark
    Cardiovasc Drugs Ther 22:305-11. 2008
    The long-term effect of beta-blockade on the plasma levels of natriuretic peptides BNP and its N-terminal counterpart, NT-proBNP, as risk markers in heart failure (HF) is obscure.
  92. ncbi Brain natriuretic peptide and endothelin-1 in the pathogenesis of polyhydramnios-oligohydramnios in monochorionic twins
    Rekha Bajoria
    Academic Unit of Obstetrics and Gynaecology, St Mary s Hospital for Women and Children, University of Manchester, Manchester, United Kingdom
    Am J Obstet Gynecol 189:189-94. 2003
    ..We investigated the association between amniotic fluid levels of human brain natriuretic peptide, endothelin-1, and abnormal amniotic fluid volume in monochorionic twins with and without chronic twin-twin transfusion syndrome...
  93. doi The plasma level of brain natriuretic peptide is increased in malnourished hemodialysis patients
    Charles Chazot
    Centre de Rein Artificiel, Tassin, France
    Blood Purif 28:187-92. 2009
    In hemodialysis (HD) patients, the plasma brain natriuretic peptide (BNP) level is associated with left ventricular dysfunction and patients' survival...
  94. ncbi Daily dialyses decrease plasma levels of brain natriuretic peptide (BNP), a biomarker of left ventricular dysfunction
    Ingegerd Odar-Cederlof
    Division of Nephrology, Karolinska University Hospital, Stockholm, Sweden
    Hemodial Int 10:394-8. 2006
    Brain natriuretic peptide or B-type natriuretic peptide (BNP) is a sensitive marker of heart disease...
  95. ncbi Atrial and brain natriuretic peptide and endothelin-1 concentration in patients with idiopathic arterial hypertension: the dependence on the selected morphological parameters
    Robert Irzmanski
    Department of Internal Diseases and Cardiological Rehabilitation, University Hospital, Medical University of Lodz, Lodz, Poland
    Clin Exp Hypertens 29:149-64. 2007
    The aim of the work was to study the maintenance of atrial and brain natriuretic peptide (ANP, BNP) and endothelin-1 (ET-1) in patients with idiopathic arterial hypertension and the relationships between cardiac morphological parameters ..
  96. ncbi Atrial natriuretic factor and brain natriuretic peptide gene expression in the spontaneous hypertensive rat during postnatal development
    M L Kuroski de Bold
    Department of Pathology, University of Ottawa Heart Institute, Ottawa Civic Hospital, ON, Canada
    Am J Hypertens 11:1006-18. 1998
    The increase in natriuretic peptides (NP), atrial natriuretic factor (ANF), and brain natriuretic peptide (BNP) production and release by cardiocytes that occurs in hypertension has been considered to be a compensatory mechanism against ..
  97. ncbi The impact of B-type natriuretic peptide in addition to troponin I, creatine kinase-MB, and myoglobin on the risk stratification of emergency department chest pain patients with potential acute coronary syndrome
    Aaron M Brown
    Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Emerg Med 49:153-63. 2007
    ..b>BNP is increased during myocardial ischemia and is associated with adverse outcomes...
  98. doi B-type natriuretic peptide as a marker for sepsis-induced myocardial depression in intensive care patients
    Felix Post
    Department of Medicine II, Johannes Gutenberg University of Mainz, Germany
    Crit Care Med 36:3030-7. 2008
    ..In this context, B-type natriuretic peptide (BNP) has been shown to be a neurohumoral marker for left ventricular dysfunction, because myocardial strain and ..
  99. ncbi Mitral annular motion as a surrogate for left ventricular function: correlation with brain natriuretic peptide levels
    Mohamed Fahmy Elnoamany
    Menofiya University, Egypt
    Eur J Echocardiogr 7:187-98. 2006
    ..Brain natriuretic peptide (BNP) levels have been shown to be elevated in patients with symptomatic LV dysfunction (Dys) and correlate to the ..
  100. ncbi Dissociation of cardiac hypertrophy, myosin heavy chain isoform expression, and natriuretic peptide production in DOCA-salt rats
    N Yokota
    University of Ottawa Heart Institute Research Centre, Ottawa Civic Hospital, Ontario, Canada
    Am J Hypertens 8:301-10. 1995
    ..chain (MHC) isoform expression, and production of atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) before and after the development of DOCA-salt hypertension...
  101. ncbi Increased plasma levels and blunted effects of brain natriuretic peptide in rats with congestive heart failure
    A Hoffman
    National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    Am J Hypertens 4:597-601. 1991
    The hemodynamic and renal effects of brain natriuretic peptide (BNP) were studied in conscious rats with experimental congestive heart failure (CHF) produced by an aortocaval fistula...

Research Grants65

  1. EXPRESSION AND REGULATION OF ATRIAL NATRIURETIC FACTOR
    David Gardner; Fiscal Year: 2002
    ..Atrial natriuretic peptide (ANP) is preferentially expressed in the cardiac atria while brain natriuretic peptide (BNP) expression shows a more equivalent distribution in atrial and ventricular myocytes...
  2. ENDOCRINE REGULATION OF CARDIAC HORMONE EXPRESSION
    CHRISTOPHER GLEMBOTSKI; Fiscal Year: 1999
    ..pressure and volume is critically dependent on a number of hormones including ANF (atrial natriuretic factor) and BNP (brain natriuretic peptide)...
  3. Yasuhiro Ikeda; Fiscal Year: 2014
    ..B-type natriuretic peptide (BNP) is a cardiac hormone which controls intravascular volume and arterial pressure to maintain the integrity of ..
  4. Polypeptide Hormone Receptor Recognition and Activation
    KENAN GARCIA; Fiscal Year: 2007
    ..of the NP system as a therapeutic target was validated in 2001 by the introduction of Brain Natriuretic Peptide (BNP) into the clinic (Natrecor(r)), as the first new treatment for congestive heart failure in 15 years...
  5. Genetic Determinants of Hypertensive Heart Disease in CRI
    Daniel L Dries; Fiscal Year: 2011
    ..to synthesis and release of natriuretic peptides (atrial natriuretic peptide [ANP], brain natriuretic peptide [BNP], and C-type natriuretic peptide [CNP]) in response to pressure or volume overload...
  6. FACTORS DETERMINING INTRAOCULAR PRESSURE
    Simon John; Fiscal Year: 2001
    ..If a genetic deficiency of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) can cause increased IOP. 2...
  7. Identifiction of the natriuretic peptide receptor kinase
    LINCOLN POTTER; Fiscal Year: 2009
    ..Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are released from the heart in response to elevated blood pressure...
  8. Joseph R Lakowicz; Fiscal Year: 2015
    ..goals for myoglobin, and are within a factor of 10 of the sensitivity needed for B-type natriuretic peptide (BNP) and cardiac troponin I (cTnl), without using biochemical amplification steps...
  9. Emmanuel S Buys; Fiscal Year: 2016
    ..with the cGMP-elevating compounds sildenafil (a phosphodiesterase (PDE) 5-antagonist), brain natriuretic peptide (BNP, a peptide activator of membrane bound guanylate cyclase (pGC)), and cinaciguat (an sGC-activator) on AqH outflow, ..
  10. Ravi Karra; Fiscal Year: 2016
    ..Our preliminar work has identified brain natriuretic peptide (nppb) as a secreted factor that is spatiotemporally related to heart regeneration...
  11. The cardiac protease corin in natriuretic peptide processing and hypertension
    Qingyu Wu; Fiscal Year: 2012
    ..Corin also cleaved pro-B-type natriuretic peptide (BNP) in vitro...
  12. Rapid homogeneous antibody-based detection of proteins
    Tomasz Heyduk; Fiscal Year: 2010
    ..be to develop molecular pincer assays for six markers of cardiac disease (troponin I, B-type natriuretic peptide (BNP), myoglobin, creatine kinase (CK-MB), C-reactive protein (CRP), and D-dimer) for research market...
  13. Pharmacogenetics of the B-type Natriuretic Peptide Pathway
    David E Lanfear; Fiscal Year: 2012
    ..The overall program will not only define functional predictive variants, but will advance the candidate's career while setting the ground work for follow-up studies of pharmacogenetically directed BNP therapy. (End of Abstract)
  14. Testing a Measurement Model of Acute Dyspnea
    Mark Parshall; Fiscal Year: 2005
    ..vital capacity and forced expiratory volume in the 1st sec) on three consecutive days; b-type natriuretic peptide (BNP) will be analyzed at study entry and exit...
  15. CARDIOVASCULAR STRESS OF SLEEP APNEA AND HEART FAILURE
    Alan Schwartz; Fiscal Year: 2005
    ..and insulin), (b) an important biomarker of acute and chronic cardiovascular stress (B-type natriuretic peptide, BNP), (c) cardiac tissue, and in (d) cardiac and CNS gene expression...
  16. LV Function Assessment Core Lab for IMMEDIATE Trial
    James Udelson; Fiscal Year: 2006
    ..perfusion imaging; b) better preserved LV function by gated SPECT imaging; and c) lower brain natriuretic peptide (BNP) levels...
  17. Determinants of Brain Natriuretic Peptide in Diabetes
    ALAIN GERALD BERTONI; Fiscal Year: 2010
    ..Cardiac myocytes release proBNP, which is cleaved into the active BNP and inactive NT-proBNP, which is more stable in blood...
  18. Myocardial Fibrosis in Heart Failure in the Elderly
    Eddy Barasch; Fiscal Year: 2004
    ..leading to diastolic (D) dysfunction and heart failure (HF), as well as increases in brain natriuretic peptide (BNP) which are predictive of outcome...
  19. Novel Insights into the Pathogenesis of Light Chain Cardiac Amyloidosis
    Flora Sam; Fiscal Year: 2011
    ..with clinical outcomes, disease progression (as determined by diastolic dysfunction on echocardiography) and BNP levels...
  20. Role of natriuretic peptides in the ductus arteriosus
    JOHN JEFFREY REESE; Fiscal Year: 2013
    ..Infants with patent ductus arteriosus (PDA) have increased ANP and BNP levels due to cardiac overload. NP levels normalize soon after PDA treatment...
  21. PREVALENCE OF ASYMPTOMATIC VENTRICULAR DYSFUNCTION
    Richard Rodeheffer; Fiscal Year: 2004
    ..both systolic and diastolic LVD are associated with elevated plasma concentrations of brain natriuretic peptide (BNP), a peptide secreted by the heart in response to increased cardiac filling pressure, that may serve as a marker to ..
  22. Novel Markers of Anthracycline-induced Myocardial Damage
    Charles L Shapiro; Fiscal Year: 2011
    ..in left ventricular ejection function (LVEF) and assess myocardial tissue damage by CMR and measure EPCs, troponins/BNP at pretreatment, after one cycle of anthracycline therapy, 4-6 weeks after completing anthracycline treatment in 30 ..
  23. Gene Therapy with Cardiotropic Vectors for the Treatment of Heart Failure
    Roger J Hajjar; Fiscal Year: 2013
    ..These novel cardiotropic vectors, which are also known as Bio Nano Particles (BNP), are based on recombinant adeno-associated virus technology which exhibit very high cardiac tropisms...
  24. Roger J Hajjar; Fiscal Year: 2014
    ..We have developed novel cardiotropic chimerics of AAV (which are also known as Bio Nano Particles (BNP) that more specifically target the heart and escape the inherent immunity in patients...
  25. Intensive glycemic control for congestive heart failure exacerbation
    KATHLEEN MARIE DUNGAN; Fiscal Year: 2012
    ..variability [BPV] and catecholamine levels), physiologic parameters, such as plasma volume, cardiac index, and BNP, quality of life, and finally the effects on adiponectin isomers, which are important adipokines important for ..
  26. Gene Based Therapy for Congestive Heart Failure
    Daniel Sigg; Fiscal Year: 2012
    ..We have proposed to use of these novel chimeric vectors, which are also known as Bio Nano Particles (BNP), to directly target I-1 in experimental models of heart failure...
  27. John C Burnett; Fiscal Year: 2016
    ..1: Establish that proBNP is a circulating hormone secreted by the normal human heart that is processed to mature BNP in the circulation. Establish that the processing of circulating proBNP by corin is impaired in CHF...
  28. Glycemic control and variability in congestive heart failure exacerbation
    Kathleen Dungan; Fiscal Year: 2009
    ..Specifically, the study will examine heart rate variability, markers of inflammation, endothelial function, BNP, oxidative stress, disease severity, and quality of life scores in patients with CHF exacerbation...
  29. Pediatric Heart Network North Carolina Consortium
    Jennifer S Li; Fiscal Year: 2010
    ..by tissue Doppler echocardiography;3) amount of myocardial scarring assessed by MRI;4) neurohormonal activation, BNP;biomarkers of collagen synthesis, procollagen I and III peptides;and 5) renin angiotensin aldosterone system ..
  30. Treatment of Functional Impairment in Heart Failure Patients with Depression
    Kenneth E Freedland; Fiscal Year: 2012
    ..quality of life, as well as medical history, left ventricular function via echocardiography, biomarkers including BNP and CRP, 6-minute walk test performance, physical activity via actigraphy, and anxiety...
  31. Paul J Mills; Fiscal Year: 2014
    ..We will enroll 522 high-risk (defined as BNP >100pg/ml) ACC/AHA Stage B patients, study them at intake, and every 6 months for an average of 30 months...
  32. ANP Receptor: Molecular approach of signaling mechanisms
    Kailash N Pandey; Fiscal Year: 2013
    ..whereby malregulation of receptor-mediated cardiac hormones;atrial and brain natriuretic peptides (ANP, BNP) bioactivity could result in abnormalities of fluid volume regulation and blood pressure homeostasis...
  33. Horng H Chen; Fiscal Year: 2016
    ..CD-NP was designed by the applicants to exploit characteristics of CNP so that CD-NP would be less hypotensive than BNP and possess renal enhancing, cardiac preload reducing and RAAS suppressing actions by integrating the C-terminus of ..
  34. GROWTH AND DEATH OF VASCULAR SMOOTH MUSCLE CELLS
    Chiming Wei; Fiscal Year: 2002
    DESCRIPTION (Adapted from Applicant's Abstract): The natriuretic peptides (NPS) include ANP, BNP and CNP. The NPS mediate their actions via generation of the second messenger cGMP following activation of biological receptors...
  35. NATRIURETIC PEPTIDES AND THE LUNG
    Nicholas Hill; Fiscal Year: 2000
    ..At the present time, 3 main NPs are known to exist; atrial (ANP), brain (BNP) and C-type natriuretic peptides (CNP)...
  36. Maha Abdellatif; Fiscal Year: 2016
    ..g. ANF, BNP, alpha skeletal actin, collagen, etc...
  37. PITCH HF (CCC) Lead Application
    Marc J Semigran; Fiscal Year: 2013
    ..Class II-IV HF with LVSD (LVEF <40%);and either: an episode of decompensated HF within 12 months, or plasma BNP level e300 pg/ml or NT-proBNP e1800pg/ml measured within 3 months...
  38. PITCH HF (DCC)
    Flora Sandra Siami; Fiscal Year: 2013
    ..Class II-IV HF with LVSD (LVEF <40%);and either: an episode of decompensated HF within 12 months, or plasma BNP level e300 pg/ml or NT-proBNP e1800pg/ml measured within 3 months...
  39. Cassandra L Fraser; Fiscal Year: 2016
    ..This objective will be accomplished by pursuing the following specific aims: 1) BNP dyes will be chemically modified for broad range emission color tuning and oxygen sensitivity modulation;imaging ..
  40. BIBHASH CHANDRA PARIA; Fiscal Year: 2014
    ..CNP is the third member of the natriuretic peptide (NP) family which also includes atrial- and brain-NPs (ANP and BNP). All NPs act via two types of guanylyl cyclase (GC) receptors, GC-A and GC-B...
  41. JASON BECKER; Fiscal Year: 2016
    ..our zebrafish model and a mouse model of HCM, discovered that the cardiac natriuretic peptide genes, nppa and nppb, were robustly induced in both HCM models...
  42. Physiologic effects of natriuretic peptide genetic variation
    Thomas J Wang; Fiscal Year: 2013
    ..In preliminary work, we have identified a common genetic variant at the NPPA/NPPB locus associated with resting NP concentrations and blood pressure...
  43. Chirag R Parikh; Fiscal Year: 2016
    ..urine and plasma biomarkers of kidney injury, such as urine IL-18, urine and plasma NGAL, urine albumin, plasma BNP, and plasma cystatin C...
  44. Robin Shandas; Fiscal Year: 2016
    ..we will biologically phenotype these patients using an established circulating marker of cardiac failure (BNP and NTproBNP) and emerging circulating biomarkers of cardiac failure (micro RNAs)...
  45. Molecular Mechanisms of Pulmonary Hypertension in COPD
    Ferhaan Ahmad; Fiscal Year: 2010
    ..the Lung Tissue Research Consortium (LTRC) from (1) subjects with COPD and a DLCO <30% of predicted and plasma BNP >40 pg/ml (associated with secondary PH) and (2) subjects with COPD and a DLCO >70% of predicted and plasma ..
  46. Horng H Chen; Fiscal Year: 2016
    ..Aim 3: Define in hospitalized decompensated CHF patients with CRS, the renal actions of low dose intravenous infusion of BNP in the presence and absence of acute PDE V inhibition in improving renal function.
  47. Amil M Shah; Fiscal Year: 2016
    ..by combining novel measures of systolic dysfunction with soluble biomarkers of myocardial stress (NT-pro-BNP) and injury (high sensitivity troponin T) to develop parsimonious risk prediction models for incident HFpEF and for ..
  48. Improving Self Management and Outcomes in Heart Failure Patients with Diabetes
    Sandra B Dunbar; Fiscal Year: 2010
    ..patient outcomes (HF and DM knowledge, self efficacy, and self care behaviors, Quality of Life, and biomarkers of BNP and HgA1c), and health care utilization (rates of readmissions, ED visits and provider contacts at 90 days;LOS, and ..
  49. 2-D Diffusion Assay on Polymer Brush for POC Cardiac Infarction Diagnosis
    Ashutosh Chilkoti; Fiscal Year: 2013
    ..preprocessing, will be multiplexed to detect cardiac troponin (cTnI) and the brain natriuretic pro-polypeptide (pro-BNP) on the same chip, and will provide quantitative read-out of analyte concentration, thereby providing a new ..
  50. Margaret M Redfield; Fiscal Year: 2016
    ..Strategies Evaluation);a randomized, double- blind, placebo-controlled trial of subcutaneous (SQ) administration of BNP added to standard therapy at hospital dismissal and continued for 30 days in patients admitted for acute heart ..
  51. Fatigue After Myocardial Infarction in Older Adults
    Patricia Crane; Fiscal Year: 2005
    ..the association between fatigue and 10 variables - age, comorbidities, beta-blockers, cardiac function (heart rate, BNP), biological factors (anemia, IL-6), sleep, depression, and social support - differ in women and men...
  52. NON-STANDARD BASE PAIRS AS BIOMEDICAL RESEARCH TOOLS
    Steven Benner; Fiscal Year: 2004
    DESCRIPTION (verbatim from the applicant's abstract): The goal of this research, chosen by the BNP Panel from a palette of science presented in the previous submission, is "to contribute to a fine-grained understanding of interactions" ..
  53. LEFT VENTRICULAR REMODELING IN AORTIC INSUFFICIENCY
    Michael Pasque; Fiscal Year: 2009
    ..Follow-up studies will be correlated with onset of symptoms, plasma BNP levels, and referral for aortic valve replacement...
  54. ATP Regulation of Membrane Guanylate Cyclase
    Teresa Duda; Fiscal Year: 2003
    Atrial natriuretic peptide family is composed of three members--ANF, BNP and CNP. These are the most hypotensive agents known to date. They work through their receptors, which are also membrane guanylate cyclases...
  55. KLF15 as a regulator of cardiomyocyte biology
    Sudeshna Fisch; Fiscal Year: 2006
    ..Adenoviral overexpression of KLF15 in neonatal rat ventricular myocytes potently inhibits the expression of ANP/BNP, and induces that of GLUT4...
  56. ISOLATED DIASTOLIC DYSFUNCTION
    MARGARET REDFIELD; Fiscal Year: 2008
    ....
  57. Regulation of the Atrial Natriuretic Peptide Receptor
    LINCOLN POTTER; Fiscal Year: 2005
    ..In response to increased blood pressure, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are secreted from the heart and stimulate vasorelaxation and fluid loss. On the other hand...
  58. Cyclic GMP And Ventricular Function In Heart Failure
    MARGARET REDFIELD; Fiscal Year: 2003
    ..abstract_text> ..
  59. Regulation of heme uptake in intestinal epithelial cells
    Aliye Uc; Fiscal Year: 2007
    ..heme uptake pathways will have a great impact in understanding disorders associated with iron overload (hereditary hemochromatosis, iron overload secondary to blood transfusions) and nutritional iron deficiency [unreadable] [unreadable]..
  60. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2010
    ..The goal of this application is to fully characterize pancreatic involvement in our novel CF pig model and to better understand the pathophysiological mechanisms leading to PI in CF. ..
  61. Regulation of Heme Uptake and Transport in Caco-2 Cells
    Aliye Uc; Fiscal Year: 2007
    ..g. hereditary hemochromatosis, iron overload secondary to blood transfusions) and explore the role of intestinal epithelial cell bi-directional heme movement on the regulation of iron stores. ..
  62. ACTION - A CHF Trial Investigating Outcomes of Exercise
    Gregg Fonarow; Fiscal Year: 2006
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  63. Cardiac Troponin Testing for Myocardial Infarction
    Fred Apple; Fiscal Year: 2001
    ..abstract_text> ..