NPM1

Summary

Gene Symbol: NPM1
Description: nucleophosmin
Alias: B23, NPM, nucleophosmin, nucleolar protein NO38, nucleophosmin (nucleolar phosphoprotein B23, numatrin), nucleophosmin/nucleoplasmin family, member 1, testicular tissue protein Li 128
Species: human

Top Publications

  1. ncbi Tryptophans 286 and 288 in the C-terminal region of protein B23.1 are important for its nucleolar localization
    Yuki Nishimura
    Department of Sustainable Resource Science, Faculty of Bioresources, Mie University, 1515 Kamihama, Tsu, Mie 514 8507, Japan
    Biosci Biotechnol Biochem 66:2239-42. 2002
  2. ncbi Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation
    Sari Kurki
    Haartman Institute and Molecular Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, P O Box 63, FIN 00014 Helsinki, Helsinki, Finland
    Cancer Cell 5:465-75. 2004
  3. ncbi Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication
    M Okuda
    Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Ohio 45267, USA
    Cell 103:127-40. 2000
  4. pmc Depletion of nucleophosmin leads to distortion of nucleolar and nuclear structures in HeLa cells
    Mohammed Abdullahel Amin
    Department of Biotechnology, Graduate School of Engineering, Osaka University, 2 1 Yamadaoka, Suita 565 0871, Osaka, Japan
    Biochem J 415:345-51. 2008
  5. pmc IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis
    Felicitas Thol
    Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Haematologica 95:1668-74. 2010
  6. pmc Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study
    Peter Paschka
    Division of Hematology and Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Clin Oncol 26:4595-602. 2008
  7. ncbi Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
    Christian Thiede
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Fetscherstrasse 74, 01307 Dresden, Germany
    Blood 107:4011-20. 2006
  8. ncbi Cellular proteins and HIV-1 Rev function
    Modem Suhasini
    Department of Immunology and Microbiology, Wayne State University, Detroit, MI, USA
    Curr HIV Res 7:91-100. 2009
  9. ncbi Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia
    N I Noguera
    Department of Biopathology, University of Tor Vergata, Rome, Italy
    Leukemia 19:1479-82. 2005
  10. ncbi Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
    Susanne Schnittger
    Department of Internal Medicine III, University Hospital Grosshadern, Ludwig Maximilian s University, Munich, Germany
    Blood 106:3733-9. 2005

Research Grants

  1. NUCLEAR PROTEINS AND REGULATION OF LYMPHOCYTE GROWTH
    Nili Feuerstein; Fiscal Year: 1993
  2. Hesham M Amin; Fiscal Year: 2015
  3. The Role of NPM-ALK Signaling in Tumor Cell Metabolism
    SCOTT RP MCDONNELL; Fiscal Year: 2012
  4. Novel role of STAT3 in NPM/ALK-induced oncogenesis
    Mariusz A Wasik; Fiscal Year: 2013
  5. Jay L Hess; Fiscal Year: 2015
  6. The Role of DNMT3B in the DNA Methylation of Cancer Cells
    LUCY ANN GODLEY; Fiscal Year: 2012
  7. Proteomic biomarkers of ALK+ lymphoma
    Megan S Lim; Fiscal Year: 2013
  8. ROCK II-mediated regulation of centrosome duplication / centrosome amplification
    Kenji Fukasawa; Fiscal Year: 2013
  9. Role of leukemia-associated protein MLF1 in apoptotic cell death
    ALAN ALI POURPAK; Fiscal Year: 2011
  10. Nucleophosmin and ribosomal dysfunction in hematologic diseases
    Pier Paolo Pandolfi; Fiscal Year: 2010

Detail Information

Publications255 found, 100 shown here

  1. ncbi Tryptophans 286 and 288 in the C-terminal region of protein B23.1 are important for its nucleolar localization
    Yuki Nishimura
    Department of Sustainable Resource Science, Faculty of Bioresources, Mie University, 1515 Kamihama, Tsu, Mie 514 8507, Japan
    Biosci Biotechnol Biochem 66:2239-42. 2002
    Nucleolar protein B23 can shuttle between the nucleolus and cytoplasm. However, the mechanism involved in the protein moving and staying in the nucleolus is not fully understood...
  2. ncbi Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation
    Sari Kurki
    Haartman Institute and Molecular Cancer Biology Research Program, Biomedicum Helsinki, University of Helsinki, P O Box 63, FIN 00014 Helsinki, Helsinki, Finland
    Cancer Cell 5:465-75. 2004
    b>Nucleophosmin (NPM, B23) is an abundant nucleolar phosphoprotein involved in ribosome biogenesis, and interacts with tumor suppressor proteins p53 and Rb...
  3. ncbi Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication
    M Okuda
    Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Ohio 45267, USA
    Cell 103:127-40. 2000
    ..We identified nucleophosmin (NPM/B23) as a substrate of CDK2/cyclin E in centrosome duplication...
  4. pmc Depletion of nucleophosmin leads to distortion of nucleolar and nuclear structures in HeLa cells
    Mohammed Abdullahel Amin
    Department of Biotechnology, Graduate School of Engineering, Osaka University, 2 1 Yamadaoka, Suita 565 0871, Osaka, Japan
    Biochem J 415:345-51. 2008
    NPM (nucleophosmin; also known as B23) is an abundantly and ubiquitously expressed multifunctional nucleolar phosphoprotein, which is involved in numerous cellular processes, including ribosome biogenesis, protein chaperoning and ..
  5. pmc IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis
    Felicitas Thol
    Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
    Haematologica 95:1668-74. 2010
    ..However, little is known about the incidence and prognostic impact of IDH1 and IDH2 mutations in myelodysplastic syndromes...
  6. pmc Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study
    Peter Paschka
    Division of Hematology and Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    J Clin Oncol 26:4595-602. 2008
    ..for the presence of FLT3 internal tandem duplications (FLT3-ITD), FLT3 tyrosine kinase domain mutations (FLT3-TKD), MLL partial tandem duplications (MLL-PTD), NPM1 and CEBPA mutations, and for the expression levels of ERG and BAALC.
  7. ncbi Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
    Christian Thiede
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Fetscherstrasse 74, 01307 Dresden, Germany
    Blood 107:4011-20. 2006
    Mutations of the nucleophosmin (NPM1) gene have recently been described in patients with acute myeloid leukemia (AML)...
  8. ncbi Cellular proteins and HIV-1 Rev function
    Modem Suhasini
    Department of Immunology and Microbiology, Wayne State University, Detroit, MI, USA
    Curr HIV Res 7:91-100. 2009
    ..Therefore, we will here focus on other Rev cofactors (eIF5a, hRIP, Sam68, RNA helicases, etc) and the role they play in Rev/RRE function and HIV-1 replication...
  9. ncbi Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia
    N I Noguera
    Department of Biopathology, University of Tor Vergata, Rome, Italy
    Leukemia 19:1479-82. 2005
    Mutations in the Nucleophosmin (NPM1) gene have been recently described to occur in about one-third of acute myeloid leukemias (AML) and represent the most frequent genetic alteration currently known in this subset...
  10. ncbi Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
    Susanne Schnittger
    Department of Internal Medicine III, University Hospital Grosshadern, Ludwig Maximilian s University, Munich, Germany
    Blood 106:3733-9. 2005
    b>Nucleophosmin (NPM1) exon-12 gene mutations are the hallmark of a large acute myelogenous leukemia (AML) subgroup with normal karyotype, but their prognostic value in this AML subset has not yet been determined...
  11. doi HIV-1 infection induces acetylation of NPM1 that facilitates Tat localization and enhances viral transactivation
    Shrikanth S Gadad
    Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India
    J Mol Biol 410:997-1007. 2011
    ..Previous studies from our group have established the role of the human histone chaperone nucleophosmin (NPM1) in the acetylation-dependent chromatin transcription. NPM1 is known to interact with HIV-Tat...
  12. pmc Nucleophosmin interacts with FOXM1 and modulates the level and localization of FOXM1 in human cancer cells
    Uppoor G Bhat
    Department of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 286:41425-33. 2011
    ..factor FOXM1 that is overexpressed in a majority of human cancers interacts with multifunctional protein NPM, which is also overexpressed in a variety of human tumors...
  13. pmc Structure of nucleophosmin DNA-binding domain and analysis of its complex with a G-quadruplex sequence from the c-MYC promoter
    Angelo Gallo
    Magnetic Resonance Center, Department of Chemistry, University of Florence, 50019 Sesto Fiorentino, Italy
    J Biol Chem 287:26539-48. 2012
    b>Nucleophosmin (NPM1) is a nucleocytoplasmic shuttling protein, mainly localized at nucleoli, that plays a key role in several cellular functions, including ribosome maturation and export, centrosome duplication, and response to stress ..
  14. ncbi Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance
    Myriam Alcalay
    IFOM IEO Campus, Via Adamello 16, 20139, Milan, Italy
    Blood 106:899-902. 2005
    ..one third of acute myeloid leukemias (AMLs) are characterized by aberrant cytoplasmic localization of nucleophosmin (NPMc+ AML), consequent to mutations in the NPM putative nucleolar localization signal...
  15. ncbi The leukemia-associated cytoplasmic nucleophosmin mutant is an oncogene with paradoxical functions: Arf inactivation and induction of cellular senescence
    K Cheng
    Cancer Biology and Genetics Program, Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Oncogene 26:7391-400. 2007
    Mutations leading to aberrant cytoplasmic localization of Nucleophosmin 1 (NPM1) have been recently identified as the most frequent genetic alteration in acute myelogenous leukemia...
  16. doi GAGE, an antiapoptotic protein binds and modulates the expression of nucleophosmin/B23 and interferon regulatory factor 1
    Rupinder K Kular
    Davee Department of Neurology, Northwestern University, Chicago, Illinois 60610, USA
    J Interferon Cytokine Res 29:645-55. 2009
    ..Furthermore, GAGE interacted with a multifunctional protein nucleophosmin (NPM)/B23 and increased its abundance by stabilizing the protein...
  17. ncbi Negative regulation of p53 by nucleophosmin antagonizes stress-induced apoptosis in human normal and malignant hematopoietic cells
    June Li
    Division of Experimental Hematology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Leuk Res 29:1415-23. 2005
    b>Nucleophosmin (NPM) is a multifunctional protein frequently overexpressed in actively proliferating cells including tumor and stem cells...
  18. doi RNA aptamers interfering with nucleophosmin oligomerization induce apoptosis of cancer cells
    Y Jian
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Oncogene 28:4201-11. 2009
    b>Nucleophosmin (NPM) is a multifunctional protein involved in both proliferation and apoptosis. Importantly, NPM negatively regulates p53 and is frequently overexpressed in a wide variety of cancers...
  19. doi Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor
    Katharina Wagner
    Department of Hematology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    J Clin Oncol 28:2356-64. 2010
    ....
  20. doi Structural basis and specificity of human otubain 1-mediated deubiquitination
    Mariola J Edelmann
    Henry Wellcome Building for Molecular Physiology, Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX37BN, UK
    Biochem J 418:379-90. 2009
    ....
  21. ncbi Ras-dependent recruitment of c-Myc for transcriptional activation of nucleophosmin/B23 in highly malignant U1 bladder cancer cells
    Chun Wei Yeh
    Cancer Biochemistry Laboratory, Department of Pharmacology, College of Medicine, Chang Gung University, 259 Wen Hwa 1st Road, Kwei San, Tao Yuan 333, Taiwan, R O C
    Mol Pharmacol 70:1443-53. 2006
    ..Higher expression of Ras, c-Myc, and nucleophosmin/B23 and greater c-Myc transactivation and nucleophosmin/B23 promoter activities were detected in U1 cells ..
  22. doi Recruitment of phosphorylated NPM1 to sites of DNA damage through RNF8-dependent ubiquitin conjugates
    Ayaka Koike
    Department of Translational Oncology, St Marianna University Graduate School of Medicine, Kawasaki, Japan
    Cancer Res 70:6746-56. 2010
    ..Here, we report a new role for the nucleophosmin protein NPM1 in these mechanisms...
  23. ncbi Lack of nucleophosmin mutation in patients with myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities
    Masayuki Shiseki
    Department of Hematology, Tokyo Women s Medical University, Tokyo, Japan
    Leuk Lymphoma 48:2141-4. 2007
    b>Nucleophosmin (NPM1) gene exon 12 mutations are frequently present in patients with acute myeloid leukemia (AML) with normal karyotype...
  24. ncbi Analysis of NPM1 gene mutations in Chinese adults with acute myeloid leukemia
    Lingzhi Yan
    Department of Hematology, First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou, PR China
    Int J Hematol 86:143-6. 2007
    Many European groups have recently described that mutations at exon-12 of the nucleophosmin (NPM1) gene are the most frequent genetic lesion in patients with acute myeloid leukemia (AML), especially in the presence of a normal karyotype...
  25. doi Multilineage dysplasia has no impact on biologic, clinicopathologic, and prognostic features of AML with mutated nucleophosmin (NPM1)
    Brunangelo Falini
    Institute of Hematology, University of Perugia, Perugia, Italy
    Blood 115:3776-86. 2010
    b>NPM1-mutated acute myeloid leukemia (AML) is a provisional entity in the 2008 World Health Organization (WHO) classification of myeloid neoplasms. The significance of multilineage dysplasia (MLD) in NPM1-mutated AML is unclear...
  26. doi Immunophenotype of acute myeloid leukemia with NPM mutations: prognostic impact of the leukemic compartment size
    J Nomdedeu
    Department of Hematology and Laboratory, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni M Claret 167, 08025 Barcelona, Spain
    Leuk Res 35:163-8. 2011
    b>NPM mutations are the most common genetic abnormalities found in non-promyelocytic AML...
  27. pmc Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation
    Mikael S Lindström
    Department of Radiation Oncology, University of North Carolina School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7512, USA
    J Biol Chem 283:15568-76. 2008
    B23 (NPM/nucleophosmin) is a multifunctional nucleolar protein and a member of the nucleoplasmin superfamily of acidic histone chaperones...
  28. doi Folding mechanism of the C-terminal domain of nucleophosmin: residual structure in the denatured state and its pathophysiological significance
    Flavio Scaloni
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Scienze Biochimiche A Rossi Fanelli, Universita di Roma La Sapienza, Rome, Italy
    FASEB J 23:2360-5. 2009
    b>Nucleophosmin (NPM1) is a ubiquitously expressed protein and is one of the most abundant proteins found in the nucleolus...
  29. pmc Deciphering the folding transition state structure and denatured state properties of nucleophosmin C-terminal domain
    Flavio Scaloni
    Istituto Pasteur Fondazione Cenci Bolognetti and Istituto di Biologia e Patologia Molecolari del Consiglio Nazionale delle Ricerche, Dipartimento di Scienze Biochimiche A Rossi Fanelli, Universita di Roma La Sapienza, Rome, Italy
    Proc Natl Acad Sci U S A 107:5447-52. 2010
    b>Nucleophosmin (NPM1), one of the most abundant nucleolar proteins, is a frequent target of oncogenic mutations in acute myeloid leukaemia (AML)...
  30. doi Akt2 and nucleophosmin/B23 function as an oncogenic unit in human lung cancer cells
    Chung Kwon Kim
    Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440 746, Korea Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440 746, Korea
    Exp Cell Res 317:966-75. 2011
    ..in notable inhibition of cell poliferation, soft agar growth, and invasion, accompanying by a decrease of nucleophosmin/B23 protein...
  31. doi Nucleophosmin delocalization in thyroid tumour cells
    Annalisa Pianta
    Dipartimento di Scienze e Tecnologie Biomediche, Universita di Udine, Piazzale Kolbe 1, 33100 Udine, Italy
    Endocr Pathol 22:18-23. 2011
    b>Nucleophosmin (NPM) is a multifunctional nucleolar protein that, depending on the context, can act as oncogene or tumour suppressor. Mutations of the NPM1 gene induce delocalization of NPM in acute myeloid leukaemia...
  32. doi The multifunctional protein nucleophosmin (NPM1) is a human linker histone H1 chaperone
    Shrikanth S Gadad
    Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, India
    Biochemistry 50:2780-9. 2011
    ..Our in vitro data show that the multifunctional histone chaperone NPM1 interacts with linker histone H1 through its first acidic stretch (residues 120-132)...
  33. pmc Knockdown of NPM1 by RNA interference inhibits cells proliferation and induces apoptosis in leukemic cell line
    Feng Xian Qin
    Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Department of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China
    Int J Med Sci 8:287-94. 2011
    b>Nucleophosmin (NPM1) is an abundant and ubiquitously expressed phosphoprotein that is known to influence solid tumors progression. However, little is known about the role of NPM1 in leukemia...
  34. doi Nucleophosmin mutation in Southeast Asian acute myeloid leukemia: eight novel variants, FLT3 coexistence and prognostic impact of NPM1/FLT3 mutations
    Chetsada Boonthimat
    Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Haematologica 93:1565-9. 2008
    b>NPM1 mutations were investigated in 400 Southeast Asian leukemia patients and were detectable in 105 cases (26.25%) of acute myeloid leukemia but in no cases of acute lymphoid leukemia or chronic myeloid leukemia...
  35. ncbi Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
    Brunangelo Falini
    Institute of Hematology, University of Perugia, Perugia, Italy
    N Engl J Med 352:254-66. 2005
    b>Nucleophosmin (NPM), a nucleocytoplasmic shuttling protein with prominent nucleolar localization, regulates the ARF-p53 tumor-suppressor pathway. Translocations involving the NPM gene cause cytoplasmic dislocation of the NPM protein.
  36. pmc A multiprotein binding interface in an intrinsically disordered region of the tumor suppressor protein interferon regulatory factor-1
    Vikram Narayan
    CRUK Interferon and Cell Signalling Group, Cell Signalling Unit, Edinburgh Cancer Research UK Centre, University of Edinburgh, Edinburgh EH4 2XR, United Kingdom
    J Biol Chem 286:14291-303. 2011
    ..Based on their function as known transcriptional regulators, a selection of the Mf2 domain-binding proteins (NPM1, TRIM28, and YB-1) have been validated using in vitro and cell-based assays...
  37. doi Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1
    Ramesh Balusu
    The University of Kansas Medical Center, KS City, KS, USA
    Blood 118:3096-106. 2011
    b>Nucleophosmin 1 (NPM1) is an oligomeric, nucleolar phosphoprotein that functions as a molecular chaperone for both proteins and nucleic acids. NPM1 is mutated in approximately one-third of patients with AML...
  38. ncbi Functional domains of the HIV-1 rev gene required for trans-regulation and subcellular localization
    L K Venkatesh
    Institute for Molecular Virology, St Louis University School of Medicine, Missouri 63110
    Virology 176:39-47. 1990
    ....
  39. doi Interaction with checkpoint kinase 1 modulates the recruitment of nucleophosmin to chromatin
    Songbi Chen
    Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7DN, United Kingdom
    J Proteome Res 8:4693-704. 2009
    ..Purified Chk1 and NPM were shown to interact in vitro and strong in vivo interactions were implied from immunoprecipitation analysis of ..
  40. ncbi Nucleolar protein B23 stimulates nuclear import of the HIV-1 Rev protein and NLS-conjugated albumin
    A Szebeni
    Department of Biochemistry, University of Mississippi Medical Center, Jackson 39216, USA
    Biochemistry 36:3941-9. 1997
    Nucleolar phosphoprotein B23 is a putative ribosome assembly factor with a relatively high affinity for peptides containing sequences of nuclear localization signals (NLSs) of the SV40 T-antigen type [Szebeni, A., Herrera, J. E...
  41. ncbi Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processing
    Pheruza Tarapore
    Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0521, USA
    FEBS Lett 580:399-409. 2006
    b>Nucleophosmin (NPM) is a multifunctional phosphoprotein, being involved in ribosome assembly, pre-ribosomal RNA processing, DNA duplication, nucleocytoplasmic protein trafficking, and centrosome duplication...
  42. pmc Denaturing high-performance liquid chromatography: a valid approach for identifying NPM1 mutations in acute myeloid leukemia
    Giovanni Roti
    Laboratory of Cytogenetics and Molecular Genetics, University of Perugia, Italy
    J Mol Diagn 8:254-9. 2006
    ..direct sequencing we previously identified six different heterozygous mutants within exon 12 encoding the nucleophosmin C-terminus...
  43. ncbi Rapid screening and sensitive detection of NPM1 (nucleophosmin) exon 12 mutations in acute myeloid leukaemia
    S Scholl
    Department of Internal Medicine II Oncology and Haematology, Friedrich Schiller University, Jena, Germany
    Leuk Res 31:1205-11. 2007
    b>Nucleophosmin mutations of exon 12 (NPM1 mutations) represent the most frequent molecular aberration that can be found in patients with acute myeloid leukaemia (AML) and can be detected in about 35% of AML patients...
  44. ncbi Nucleolin modulates the subcellular localization of GDNF-inducible zinc finger protein 1 and its roles in transcription and cell proliferation
    Atsushi Dambara
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Exp Cell Res 313:3755-66. 2007
    ..Finally, we found that knockdown of GZF1 and nucleolin expression markedly impaired cell proliferation. These findings suggest that the physiological functions of GZF1 may be regulated by the protein's association with nucleolin...
  45. pmc APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process
    Carlo Vascotto
    Department of Biomedical Sciences and Technologies, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Mol Cell Biol 29:1834-54. 2009
    ..In particular, a novel interaction between nucleophosmin (NPM1) and APE1 was characterized...
  46. pmc Nucleophosmin is essential for ribosomal protein L5 nuclear export
    Yue Yu
    Department of Internal Medicine, Division of Molecular Oncology, Siteman Cancer Center, Washington University School of Medicine, Campus Box 8069, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Mol Cell Biol 26:3798-809. 2006
    b>Nucleophosmin (NPM/B23) is a key regulator in the regulation of a number of processes including centrosome duplication, maintenance of genomic integrity, and ribosome biogenesis...
  47. pmc The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing
    Markus Haindl
    Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    EMBO Rep 9:273-9. 2008
    ..Here, we show that the nucleolar SUMO-specific protease SENP3 is associated with nucleophosmin (NPM1), a crucial factor in ribosome biogenesis...
  48. ncbi Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth
    W Y Chan
    Protein Studies Program, Oklahoma Medical Research Foundation, Oklahoma City 73104
    Biochemistry 28:1033-9. 1989
    ..The cluster consists of 26 Asp/Glu and 1 Phe and Ala. Comparison of human nucleophosmin and Xenopus nucleolar protein NO38 shows 64.3% sequence identity...
  49. ncbi The roles of nucleolar structure and function in the subcellular location of the HIV-1 Rev protein
    M Dundr
    Department of Biochemistry, University of Mississippi Medical Center, Jackson 39216, USA
    J Cell Sci 108:2811-23. 1995
    ..Previous studies demonstrated that the Rev protein forms a specific complex in vitro with protein B23 which is suggested to be a nucleolar receptor and/or carrier for the Rev protein...
  50. ncbi Spatial association of HIV-1 tat protein and the nucleolar transport protein B23 in stably transfected Jurkat T-cells
    W A Marasco
    Division of Human Retrovirology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts
    Arch Virol 139:133-54. 1994
    ..Two nucleocytoplasmic shuttle proteins C23/nucleolin and B23 and a third nucleolar antigen that was detected by monoclonal antibody MAb 1277 were also examined...
  51. pmc Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)
    J Fujimoto
    Department of Oncology, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 93:4181-6. 1996
    ..protein p80 was shown to be generated by fusion of a protein-tyrosine kinase and a nucleolar protein B23/nucleophosmin (NPM)...
  52. pmc Nucleolar protein B23 has molecular chaperone activities
    A Szebeni
    Department of Biochemistry, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Protein Sci 8:905-12. 1999
    Protein B23 is an abundant, multifunctional nucleolar phosphoprotein whose activities are proposed to play a role in ribosome assembly. Szebeni et al...
  53. ncbi In vivo interaction of nucleophosmin/B23 and protein C23 during cell cycle progression in HeLa cells
    H T Liu
    Department of Pharmacology, College of Medicine, Chang Gung University, Kwei San, Tao Yuan, Taiwan
    Cancer Lett 144:45-54. 1999
    By using the cross-linking reagent, DSP, efforts were made to identify the protein(s) that interact with nucleophosmin/B23...
  54. ncbi Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication
    Y Tokuyama
    Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0521, USA
    J Biol Chem 276:21529-37. 2001
    ..We have recently found that nucleophosmin (NPM/B23), a phosphoprotein primarily found in nucleolus, associates with unduplicated centrosomes and is a ..
  55. ncbi B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1
    Hong Zhang
    Kinexus Bioinformatics Corp, Vancouver, British Columbia V6T 1Z3
    J Biol Chem 279:35726-34. 2004
    ..treatment revealed that a novel mitosis-specific phosphorylation event occurred in the nucleolar protein B23/nucleophosmin at a conserved Ser-4 residue...
  56. ncbi Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia
    Tatsuya Suzuki
    Department of Infectious Diseases, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Blood 106:2854-61. 2005
    Recently, somatic mutations of the nucleophosmin gene (NPM1), which alter the subcellular localization of the product, have been reported in acute myeloid leukemia (AML)...
  57. pmc Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription
    V Swaminathan
    Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Jakkur, Bangalore, India
    Mol Cell Biol 25:7534-45. 2005
    ..Here, we report that the human histone chaperone nucleophosmin interacts with the core histones H3, H2B, and H4 but that this histone interaction is not sufficient to confer ..
  58. ncbi Myeloid leukemia-associated nucleophosmin mutants perturb p53-dependent and independent activities of the Arf tumor suppressor protein
    Willem den Besten
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cell Cycle 4:1593-8. 2005
    b>Nucleophosmin (NPM or B23) plays key roles in ribosome biogenesis, centrosome duplication, and maintenance of genomic integrity...
  59. ncbi NPM1 mutations in myelodysplastic syndromes and acute myeloid leukemia with normal karyotype
    Yue Zhang
    State Key Laboratory of Experiment Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, PR China
    Leuk Res 31:109-11. 2007
    Mutations at exon 12 of the nucleophosmin (NPM1) gene are the most frequent acquired molecular abnormalities in adult and pediatric acute myeloid leukaemia (AML) with normal karyotype...
  60. pmc Specificity protein 1-dependent p53-mediated suppression of human manganese superoxide dismutase gene expression
    Sanjit Kumar Dhar
    Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 281:21698-709. 2006
    ..We also identified nucleophosmin (NPM), an RNA-binding protein, as an important co-activator of NF-kappaB in the induction of MnSOD by cytokine ..
  61. pmc The incidence and clinical significance of nucleophosmin mutations in childhood AML
    Patrick Brown
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Blood 110:979-85. 2007
    Frameshift mutations in exon 12 of the nucleophosmin gene (NPM1) result in aberrant cytoplasmic localization of the NPM protein (NPMc(+)) and occur in 25% to 35% of adult acute myeloid leukemia (AML)...
  62. ncbi Born to be exported: COOH-terminal nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutants
    Niccolò Bolli
    Section of Hematology and Immunology, University of Perugia, Perugia, Italy
    Cancer Res 67:6230-7. 2007
    ..export signal (NES) motif and loss of tryptophans (W) 288 and 290 (or 290 only) at the COOH terminus of nucleophosmin (NPM) are both crucial for NPM aberrant cytoplasmic accumulation in acute myelogenous leukemia (AML) carrying ..
  63. ncbi Release of angiopoietin-1 by primary human acute myelogenous leukemia cells is associated with mutations of nucleophosmin, increased by bone marrow stromal cells and possibly antagonized by high systemic angiopoietin-2 levels
    K J Hatfield
    Section of Hematology, Institute of Medicine, University of Bergen, Bergen, Norway
    Leukemia 22:287-93. 2008
    ..by characterizing whether the differences in angiopoietin expression in AML patients can be related to nucleophosmin (NPM1) mutations...
  64. doi Mutations of NPM1 gene in de novo acute myeloid leukaemia: determination of incidence, distribution pattern and identification of two novel mutations in Indian population
    Firoz Ahmad
    Research and Development Division, SRL Ranbaxy Ltd, Andheri E, Mumbai 400093, India
    Hematol Oncol 27:90-7. 2009
    Mutations in the nucleophosmin (NPM1) gene have been recently described to occur in about one-third of acute myeloid leukaemias (AMLs) and represent the most frequent genetic alteration currently known in this subset, specially in those ..
  65. doi Non-A type nucleophosmin 1 gene mutation predicts poor clinical outcome in de novo adult acute myeloid leukemia: differential clinical importance of NPM1 mutation according to subtype
    Youngil Koh
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Int J Hematol 90:1-5. 2009
    Mutations of nucleophosmin gene (NPM1) are known to be related to good prognosis in AML patients lacking FLT3 internal tandem duplication (FLT3-ITD)...
  66. pmc Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element
    C Fankhauser
    Department of Biochemistry, University of Geneva, Switzerland
    Mol Cell Biol 11:2567-75. 1991
    ..A single, tightly associated Rev-binding protein was identified; this protein is the mammalian nucleolar protein B23. The interaction between HIV Rev and B23 is very specific, as it was observed in complex cell extracts...
  67. ncbi The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1
    N Yoneda-Kato
    Department of Experimental Oncology, St Jude Children s Research Hospital
    Oncogene 12:265-75. 1996
    ..associated with myelodysplastic syndrome and acute myeloid leukemia (AML) was found to rearrange part of the nucleophosmin (NPM) gene on chromosome 5 with sequences from a novel gene on chromosome 3...
  68. ncbi C23 interacts with B23, a putative nucleolar-localization-signal-binding protein
    Y P Li
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    Eur J Biochem 237:153-8. 1996
    ..with other proteins were studied with the two-hybrid system which identified nucleolar protein B23 (nucleophosmin) as being associated with C23...
  69. ncbi Expression of nucleophosmin/B23 in normal and neoplastic colorectal mucosa
    Y Nozawa
    Department of Pathology, Erasmus University Rotterdam, The Netherlands
    J Pathol 178:48-52. 1996
    b>Nucleophosmin/B23 is a 38 kD molecular phosphoprotein involved in ribosome assembly and transport...
  70. ncbi Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone
    M Okuwaki
    Laboratory of Cellular Biochemistry, RIKEN The Institute of Physical and Chemical Research, Wako, Japan
    FEBS Lett 506:272-6. 2001
    We previously identified and purified a nucleolar phosphoprotein, nucleophosmin/B23, as a stimulatory factor for replication from the adenovirus chromatin...
  71. pmc The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtype
    Mitsuru Okuwaki
    Department of Infection Biology, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennohdai, Tsukuba 305 8575, Japan
    Mol Biol Cell 13:2016-30. 2002
    b>Nucleophosmin/B23 is a nucleolar phosphoprotein. It has been shown that B23 binds to nucleic acids, digests RNA, and is localized in nucleolar granular components from which preribosomal particles are transported to cytoplasm...
  72. ncbi Nucleophosmin regulates the stability and transcriptional activity of p53
    Emanuela Colombo
    European Institute of Oncology, Department of Experimental Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Nat Cell Biol 4:529-33. 2002
    b>Nucleophosmin (NPM) is a ubiquitously expressed nucleolar phosphoprotein that continuously shuttles between the nucleus and cytoplasm...
  73. ncbi UV stimulation of nucleophosmin/B23 expression is an immediate-early gene response induced by damaged DNA
    Ming H Wu
    Graduate Institute of Pharmacology, National Yang Ming University, Taipei 112, Taiwan, Republic of China
    J Biol Chem 277:48234-40. 2002
    b>Nucleophosmin/B23 (NPM/B23), a nucleolar protein, was rapidly up-regulated after UV irradiation (at 254 nm; 30 J/m(2)) in NIH 3T3 cells and HeLa/S3 cells...
  74. ncbi Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation
    Koji Itahana
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell 12:1151-64. 2003
    ..Here we show that ARF interacts with B23, a multifunctional nucleolar protein involved in ribosome biogenesis, and promotes its polyubiquitination and ..
  75. ncbi PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli
    Véronique S Meder
    UPR 9003 du Centre National de la Recherche Scientifique, Laboratoire conventionné avec le Commissariat à l Energie Atomique, Universite Louis Pasteur, Ecole Superieure de Biotechnologie de Strasbourg, Illkirch, France
    J Cell Sci 118:211-22. 2005
    ..PARP-2 is enriched within the whole nucleolus and partially colocalizes with the nucleolar factor nucleophosmin/B23...
  76. pmc Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function
    Chandrashekhar Korgaonkar
    Department of Pharmacology, The University of Iowa, College of Medicine, Iowa City, IA 52242, USA
    Mol Cell Biol 25:1258-71. 2005
    ..provide evidence that it is sequestered and held inactive in that compartment by a nucleolar phosphoprotein, nucleophosmin (NPM)...
  77. ncbi Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype
    Giovanni Cazzaniga
    Centro Ricerca Tettamanti, Clinica Pediatrica University of Milano Bicocca, Ospedale San Gerardo, 20052 Monza, Italy
    Blood 106:1419-22. 2005
    b>Nucleophosmin (NPM) is a nucleocytoplasmic shuttling protein involved in leukemia-associated chromosomal translocations, and it regulates the alternate reading frame (ARF)-p53 tumor-suppressor pathway...
  78. ncbi Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication
    Wei Wang
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute NIH, Bethesda, MD 20892, USA
    Nat Cell Biol 7:823-30. 2005
    ..Here, we discover that nucleophosmin (NPM) may be a Ran-Crm1 substrate that controls centrosome duplication...
  79. ncbi Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype
    Nicolas Boissel
    Service d hématologie adulte, Hopital Saint Louis, Paris, France
    Blood 106:3618-20. 2005
    Mutation of the nucleophosmin (NPM) gene has been reported as the most frequent mutation in acute myeloid leukemia (AML), especially in the presence of a normal karyotype...
  80. ncbi Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML
    Brunangelo Falini
    Institute of Hematology, University of Perugia, 06122 Perugia, Italy
    Blood 107:4514-23. 2006
    We recently identified aberrant cytoplasmic expression of nucleophosmin (NPM) as the immunohistochemical marker of a large subgroup of acute myeloid leukemia (AML) (about one-third of adult AML) that is characterized by normal karyotype ..
  81. ncbi Nucleolar protein B23 interacts with Japanese encephalitis virus core protein and participates in viral replication
    Yoshimi Tsuda
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    Microbiol Immunol 50:225-34. 2006
    ..In this study, we identified a nucleolar phosphoprotein B23 as a protein binding with the core protein of JEV but not with that of dengue virus...
  82. ncbi Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability
    Takeharu Enomoto
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, NC 27599 7512, USA
    J Biol Chem 281:18463-72. 2006
    ..the tumor suppressor p14(ARF) (ARF) has been shown to interact functionally with the nucleolar protein B23/NPM (B23) and inhibit rRNA biogenesis. However, the molecular basis of the ARF-B23 interaction is hitherto unclear...
  83. ncbi DNA damage, p14ARF, nucleophosmin (NPM/B23), and cancer
    Ruth A Gjerset
    Sidney Kimmel Cancer Center, 10835 Road to the Cure previously Altman Row, San Diego, CA 92121, USA
    J Mol Histol 37:239-51. 2006
    ..Recently, Nucleophosmin (NPM, B23, NO38 and numatrin), a multifunctional nucleolar protein, has emerged as a p14ARF binding protein ..
  84. ncbi Effects of interphase and mitotic phosphorylation on the mobility and location of nucleolar protein B23
    Sandeep S Negi
    Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Cell Sci 119:3676-85. 2006
    B23 (or nucleophosmin, NPM) is a multifunctional protein involved in ribosome biogenesis, control of centrosome duplication and in sensing cellular stress...
  85. ncbi Different types of NPM1 mutations in children and adults: evidence for an effect of patient age on the prevalence of the TCTG-tandem duplication in NPM1-exon 12
    C Thiede
    Leukemia 21:366-7. 2007
  86. pmc Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation
    Hsuan Liu
    Cancer Biochemistry Laboratory, Department of Pharmacology, Chang Gung University, 259 Wen Hwa 1st Road, Kwei San, Tao Yuan 333, Taiwan, Republic of China
    EMBO Rep 8:394-400. 2007
    b>Nucleophosmin (NPM) is an important nucleolar phosphoprotein with pleiotropic functions in various cellular processes...
  87. ncbi Absence of nucleophosmin 1 (NPM1) gene mutations in common solid cancers
    Eun Goo Jeong
    Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea
    APMIS 115:341-6. 2007
    b>Nucleophosmin is a nucleolar phosphoprotein that shuttles between nucleus and cytoplasm. Recent reports demonstrated that exon 12 of the nucleophosmin 1 (NPM1) gene was frequently mutated in acute myelogenous leukemias (AMLs)...
  88. pmc Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival
    Xia Liu
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:9679-84. 2007
    b>Nucleophosmin/B23 is a major multifunctional nucleolar phosphoprotein that plays a critical role in ribosome biogenesis and cell proliferation. Arf tumor suppressor binds B23 and enhances its sumoylation...
  89. ncbi Physical and functional interaction between a nucleolar protein nucleophosmin/B23 and adenovirus basic core proteins
    Mohammad Abdus Samad
    Graduate School of Comprehensive Human Sciences and Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennohdai, Tsukuba, Japan
    FEBS Lett 581:3283-8. 2007
    We identified nucleophosmin/B23 as a component of template-activating factor-III that stimulates the DNA replication from the adenovirus DNA complexed with viral basic core proteins...
  90. ncbi Aberrant cytoplasmic expression of C-terminal-truncated NPM leukaemic mutant is dictated by tryptophans loss and a new NES motif
    B Falini
    Leukemia 21:2052-4; author reply 2054; discussion 2055-6. 2007
  91. ncbi Association of nucleophosmin negatively regulates CXCR4-mediated G protein activation and chemotaxis
    Wenbo Zhang
    Department of Pathology, Medical College of Georgia, Augusta, GA 30912, USA
    Mol Pharmacol 72:1310-21. 2007
    ..Analysis of CXCR4 immune complexes identified nucleophosmin (NPM), which was confirmed by reciprocal coimmunoprecipitation for NPM...
  92. ncbi Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface
    Hyung Ho Lee
    Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    Proteins 69:672-8. 2007
  93. ncbi Ebp1 association with nucleophosmin/B23 is essential for regulating cell proliferation and suppressing apoptosis
    Masashi Okada
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:36744-54. 2007
    Ebp1 and NPM/B23 are essential for cell proliferation and survival. Ebp1 possesses p42 and p48 isoforms. Whereas p42 exclusively resides in the cytoplasm, p48 localizes in both the cytoplasm and the nucleolus...
  94. ncbi Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas
    A Colomba
    INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    Oncogene 27:2728-36. 2008
    The majority of anaplastic large cell lymphomas (ALCLs) express the nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) fusion protein, which is oncogenic due to its constitutive tyrosine kinase activity...
  95. ncbi Influence of nucleophosmin/B23 on DNA binding and transcriptional activity of the androgen receptor in prostate cancer cell
    L Leotoing
    UMR 6547 CNRS Université Blaise Pascal Clermont Ferrand II, Aubiere Cedex, France
    Oncogene 27:2858-67. 2008
    ..AR functions are modulated by a variety of co-factors amongst which we identified the nucleophosmin (NPM/B23), a member of the histone chaperone family...
  96. doi DR negativity is a distinctive feature of M1/M2 AML cases with NPM1 mutation
    Meilani Syampurnawati
    International Center for Medical Research and Treatment ICMRT, Graduate School of Medicine, Kobe University, Chuo Ku, Kobe 650 0017, Japan
    Leuk Res 32:1141-3. 2008
    ..observation of a higher incidence of FLT3-ITD in DR(-) M1/M2 AML than in DR(+) M1/M2 led to an investigation of NPM1 mutation in the same samples, since DR(-) AML and AML with NPM1 mutation share such characteristics as normal ..
  97. doi NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia
    Brunangelo Falini
    Institute of Hematology, University of Perugia, Perugia, Italy
    Haematologica 93:439-42. 2008
    Acute myeloid leukemia carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc(+) acute myeloid leukemia) represents one-third of adult AML (50-60% of all acute myeloid leukemia with normal karyotype) and shows distinct biological, ..
  98. doi Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples
    Ke Hung Tsui
    Chang Gung Bioinformatics Center, Department of Urology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kwei Shan, Taiwan, China
    Acta Pharmacol Sin 29:364-70. 2008
    To investigate the possible correlation of nucleophosmin/B23 expression with bladder carcinoma recurrence.
  99. doi p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation
    Maria Emanuela Cuomo
    Cancer Research UK, Centre for Cell and Molecular Biology, The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, SW3 6JB London, UK
    Nat Cell Biol 10:723-30. 2008
    ..We have identified NPM1 as a substrate for CDK6 activated by the Kaposi's sarcoma herpesvirus (KSHV) D-type cyclin and shown that p53-..
  100. doi Nucleophosmin mutations in Chinese adults with acute myelogenous leukemia
    Guo Rui Ruan
    Peking University Institute of Hematology and People s Hospital, Beijing, China
    Ann Hematol 88:159-66. 2009
    Recently, mutations in the nucleophosmin (NPM1) gene were detected in 50-60% of adult acute myelogenous leukemia (AML) patients, mainly with a normal karyotype...

Research Grants57

  1. NUCLEAR PROTEINS AND REGULATION OF LYMPHOCYTE GROWTH
    Nili Feuerstein; Fiscal Year: 1993
    ....
  2. Hesham M Amin; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Nucleophosmin-anaplastic lymphoma kinase-expressing anaplastic large-cell lymphoma (NPM-ALK+ ALCL) is an aggressive type of T-cell lymphoma...
  3. The Role of NPM-ALK Signaling in Tumor Cell Metabolism
    SCOTT RP MCDONNELL; Fiscal Year: 2012
    ..is the chromosomal translocation t (2;5)(p23;q35) resulting in the aberrant expression of the fusion protein nucleophosmin - anaplastic lymphoma kinase (NPM-ALK)...
  4. Novel role of STAT3 in NPM/ALK-induced oncogenesis
    Mariusz A Wasik; Fiscal Year: 2013
    ..ALK is aberrantly expressed (most frequently as the NPM/ALK fusion protein) and/or activated in a subset of human T-cell and B-cell lymphomas, inflammatory myofibroblastic ..
  5. Jay L Hess; Fiscal Year: 2015
    ..a histone H3 lysine 4 specific methyltransferase (involved in approximately 10% of all AML cases), mutation of nucleophosmin (NPM1), resulting in its re-localization to the cytoplasm (NPMc+)(approximately 35% of AML cases) or ..
  6. The Role of DNMT3B in the DNA Methylation of Cancer Cells
    LUCY ANN GODLEY; Fiscal Year: 2012
    ..characterizing the interactions between DNMT3B/DNMT3B7 and three exciting interacting proteins, ZNF445, CHTF18, and NPM. Our proposed studies address the mechanism by which epigenetic alterations originate within cancer cells...
  7. Proteomic biomarkers of ALK+ lymphoma
    Megan S Lim; Fiscal Year: 2013
    ..The t(2;5)(p23;q35) chromosomal aberration resulting in overexpression of a chimeric oncogene, nucleophosmin-anaplastic lymphoma kinase (NPM/ALK) is the most common translocation found in these tumors...
  8. ROCK II-mediated regulation of centrosome duplication / centrosome amplification
    Kenji Fukasawa; Fiscal Year: 2013
    ..and acts as a key regulatory protein for the initiation of centrosome duplication in association with nucleophosmin (NPM/B23)...
  9. Role of leukemia-associated protein MLF1 in apoptotic cell death
    ALAN ALI POURPAK; Fiscal Year: 2011
    ..Myeloid leukemia factor 1 (MLF1) was first identified as a fusion partner with nucleophosmin (NPM), expressed as the chimeric protein NPM-MLF1, in a subset of patients with myelodysplastic syndrome (MDS) ..
  10. Nucleophosmin and ribosomal dysfunction in hematologic diseases
    Pier Paolo Pandolfi; Fiscal Year: 2010
    ..We have previously identified the NPM1 gene as a strong candidate gene responsible for disease progression in MDS patients with deletion of 5q, the ..
  11. Kapil Bhalla; Fiscal Year: 2016
    ..Approximately 30% of AML carry a heterozygous mutation in the nucleophosmin 1 (NPM1), which results in the cytoplasmic dislocation of the mutant NPM1 (mtNPM1)...
  12. FUSION PROTEINS IN THE MOLECULAR PATHOGENESIS OF APL
    Pier Paolo Pandolfi; Fiscal Year: 2009
    ..associated with reciprocal translocations always involving the RARalpha locus that variably fuses to the PML, PLZF, NPM, NuMA or STAT5b genes (referred to as X genes)...
  13. JORDAN JAMES WRIGHT; Fiscal Year: 2014
    ..I describe preliminary studies in which I have found that secretion of one of the MIDY mutants, proinsulin-G(B23)V, is actually rescued by co-expression with an increasing concentration of wild- type (WT) proinsulin - even as WT ..
  14. Experimental Therapeutics of Leukemia
    John C Byrd; Fiscal Year: 2013
    ..This project will study the impact of select prognostic gene (FLT3 ITD, MLL PTD, NPM1, WT-1, CEBPA, KIT) mutations, aberrant gene (BAALC, ERG, FLT3, MN1 and EVI1) expression, and mRNA/miRNA expression ..
  15. In vivo functional characterization of Myelodysplasia/Myeloid Leukemia Factor
    JAMIE OLIVIA DYER; Fiscal Year: 2013
    ..1;q34) chromosomal translocation produces a fusion protein consisting of the nucleolar phosphoprotein nucleophosmin (NPM) and myelodysplasia/myeloid leukemia factor 1 (MLF1), which is associated with the formation of ..
  16. Aging and sensitivity to traffic-generated air pollutants in male and female mice
    Caleb E Finch; Fiscal Year: 2012
    ..young rodents show glial inflammatory changes with defined exposure to traffic-generated nano-sized PM (nPM) (Zanchi et al 2010;Kleinman et al 2008)...
  17. Role of MAP kinases in anaplastic large cell lymphoma
    Youli Zu; Fiscal Year: 2009
    ..ALCL have an abnormal chromosome translocation t(2;5)(p23;q35), which results in a fusion gene composed of nucleophosmin (NPM) and a truncated tyrosine kinase, named anaplastic lymphoma kinase (ALK)...
  18. Multiplex Detection of Mutations in Leukemia Patients
    Emmanuel Labourier; Fiscal Year: 2010
    ..This resulted in the launch of an RUO diagnostic kit for the detection of NPM1 mutations (Signature(R) NPM1 Mutations)...
  19. Harold I Saavedra; Fiscal Year: 2014
    ..amplification and mammary tumor initiation by through a classical pathway involving Cdk4 phosphorylation of NPM, and through an alternative pathway involving ectopically-expressed Nek2...
  20. Signal Transduction in Lymphoma
    Christopher Carpenter; Fiscal Year: 2006
    ..ALK is usually activated by a 2:5 chromosomal translocation that produces a fusion with nucleophosmin (NPM), called NPM-ALK...
  21. NPM-ALK & CD30 Signaling in Anaplastic Cell Lymphoma
    Henry Koon; Fiscal Year: 2007
    ..and 50-60% of ALCL are characterized by the t (2;5) translocation which produces a fusion protein between Nucleophosmin on chromosome 5 and Anaplastic Lymphoma Kinase (ALK) on chromosome 2...
  22. Ralph Scully; Fiscal Year: 2014
    ..basis of H2AX/MDC1-mediated HR/SCR, by analyzing a new MDC1-interacting protein complex involving TRIP12 and nucleophosmin (NPM1), which we have recently identified...
  23. Steven C Borkan; Fiscal Year: 2016
    ..We hypothesize that interaction between conformationally active Bax and nucleophosmin (NPM), a recently described Bax chaperone, is required to form cytosolic complexes that translocate Bax to ..
  24. INTEGRATION OF ONCOGENIC SIGNALS BY THE NUCLEOLAR ARF-NPM NETWORK
    Jason Weber; Fiscal Year: 2012
    ..Numerous labs, including ours, have identified the nucleophosmin (NPM) proto-oncogene as a nucleolar binding partner of ARF...
  25. Air Pollution and vulnerability to Alzheimer-like neurodegeneration in mice
    Caleb E Finch; Fiscal Year: 2012
    ..Corresponding rodent models with defined exposure to traffic-generated nano-sized particulate material (nPM) have shown glial inflammatory changes...
  26. Function of Nucleophosmin/B23 in Centrosome Duplication
    Kenji Fukasawa; Fiscal Year: 2006
    ..We have recently found that nucleophosmin (NPM)/B23 is a key centrosomal target of CDK2 in the initiation of centrosome duplication...
  27. Nursing Practice Models in Long-Term Care Facilities
    Christine Mueller; Fiscal Year: 2003
    ..and provide nurse administrators in LTC facilities a decision making tool to characterize and diagnose their NPM and modify aspects of the NPM to improve resident, staff and organizational outcomes...
  28. Molecular characterization of normal cytogenetics AML in older patients
    Guido Marcucci; Fiscal Year: 2009
    ..internal tandem duplication of the FLT3 gene, partial tandem duplication of the MLL gene, mutations in the NPM1 and CEBPA genes high expression of the ERG and BAALC genes...
  29. Analysis of APL-Fusion Retinoic Acid Receptor Proteins
    Shuo Dong; Fiscal Year: 2006
    ..also have been described in APL patients: t(11;17), t(5;17), t(11;17) and del(17), which produce PLZF-RARalpha, NPM-RARalpha, NuMA-RARalpha and STAT5b-RARalpha fusion proteins, respectively...
  30. Characterization of p53-independent ARF pathway
    Jason Weber; Fiscal Year: 2007
    ..In search of p53-independent ARF targets, we isolated a novel ARF binding protein, nucleophosmin (NPM)...
  31. NPM/MLF1 IN LEUKEMIA AND NORMAL DEVELOPMENT
    Stephan Morris; Fiscal Year: 2002
    ..syndrome (MDS) and acute myeloid leukemia (AML) creates a fusion product in which the amino-terminus of nucleophosmin (NPM), a nucleolar shuttle protein, is linked to the novel protein myelodysplasia/myeloid leukemia factor 1 (..
  32. NPM ALK mediated transformation of T lymphocytes
    David Levy; Fiscal Year: 2006
    ..provided by applicant) The overall goal of this application is to study the molecular and biological role of the NPM-ALK fusion product derived from the translocation 1(2;5) characteristic of anaplastic large cell lymphomas (ALCL)...
  33. X-RAR alpha proteins: Molecualr Pathogenesis of Acute Promyelocytic Leukemia
    Pier Paolo Pandolfi; Fiscal Year: 2010
    ..which involve the RARa locus on chromosome 17 which variably translocates and fuses to the PML, PLZF, NPM or NuMA genes (for brevity referred to as X genes/proteins)...
  34. NOVEL TRANSLOCATION PRODUCT IN APL
    ROBERT REDNER; Fiscal Year: 1999
    ..We show that this translocation links 5' elements of the nucleolar protein nucleophosmin (NPM) to 3' elements of RARa...
  35. Structure and Function of Histone Chaperones
    CHRISTOPHER AKEY; Fiscal Year: 2007
    ..Somatic members of the Np-family are nucleolar proteins (NO38, B23, ANO39 and Mp62) which may help remodel r-chromatin during ribosome biogenesis...
  36. Characterization of a Novel Translocation Product in APL
    ROBERT REDNER; Fiscal Year: 2009
    ..This translocation generates an in-frame fusion of the N-terminal 117 amino acids of nucleophosmin (NPM) with the C-terminal 403 amino acids of the retinoic acid receptor alpha (RARa)...
  37. PML, PLZF, NPM AND NUMA IN THE PATHOGENESIS OF APL
    Pier Paolo Pandolfi; Fiscal Year: 2005
    ..is associated with reciprocal tranlocations always involving the RARa locus which variably fuses to the PML, PLZF, NPM or NuMA genes (referred to as X genes)...
  38. ESTROGEN INDUCED PROGRESSION IN BREAST CANCER
    Robert Clarke; Fiscal Year: 2001
    ..Using 2-D gel analysis, the applicant has identified nucleophosmin (NPM) as a protein associated with acquired E2-independence...
  39. NPM-ALK AND ALK IN LYMPHOMA AND NORMAL DEVELOPMENT
    Stephan Morris; Fiscal Year: 2006
    ..abstract_text> ..
  40. Study the Preventing Effect of IKKalpha on Tumor Develo*
    Yinling Hu; Fiscal Year: 2006
    ..and TNFalpha, and the genomic instability, such as deregulating expression of multiple genes, including nucleophosmin (NPM) and 14-3-3sigma that are involved in chromosome duplication, DNA repair, and cell cycle control...
  41. The Role of Merlin Phosphorylation on its Tumor Suppressive Activity
    Keqiang Ye; Fiscal Year: 2010
    ..abstract_text> ..
  42. A New Antioxidant Prevents Toxicity of HIV Proteins with Methamphetamine
    Nuran Ercal; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  43. Role of Jak3 in Anaplastic Large Cell Lymphoma
    HESHAM AMIN; Fiscal Year: 2008
    ..The direct aim of the proposed studies is to validate Jak3 as a therapeutic target in patients afflicted with this dreadful disease. [unreadable] [unreadable] [unreadable]..
  44. FLT3 GENOTYPES IN ACUTE MYELOID LEUKEMIA
    Susan Whitman; Fiscal Year: 2006
    ..abstract_text> ..
  45. (m) TOR signaling in EBV-associated lymphomas
    Mariusz Wasik; Fiscal Year: 2007
    ..role of TOR signaling in cell transformation of the lymphoma cells These studies may result in novel diagnostic and therapeutic approaches to the EBV-associated lymphomas in HIV/AIDS and other patients. ..
  46. FHIT Gene Therapy in Cancer Prevention and Treatment
    Carlo M Croce; Fiscal Year: 2011
    ..abstract_text> ..
  47. Quantitative RT-PCR: Prediction Lymphoma Transformation
    Kojo Elenitoba Johnson; Fiscal Year: 2005
    ....
  48. Tumor-reactive IgG in the diagnosis of ovarian cancer
    Douglas Taylor; Fiscal Year: 2005
    ..Ultimately, antigenic proteins, linked with histologic type and stage of disease, will be combined into the development of protein arrays to screen for circulating reactive IgG as an early diagnostic test. ..
  49. Computer Directed Photodynamic Therapy of Prostate Ca
    Jerzy Jankun; Fiscal Year: 2005
    ....
  50. 8P22 ALTERATIONS, IN PROSTATE, BREAST AND ESOPHAGEAL CA
    Carlo Croce; Fiscal Year: 2004
    ..We will also determine whether Fez1 loss of function makes cancer cells more resistant to chemotherapeutic drugs. Finally, we will determine whether FHIT and Fez1 are collaborating tumor suppressor genes ..
  51. Arsenic Trioxide Down-Regulates STAT3 Activity in AML
    Meir Wetzler; Fiscal Year: 2004
    ..In addition, we will attempt to identify the mode by which ATO controls the activity of STAT3 and how this effect alters the gene profile patterns and induces apoptosis. ..
  52. ARP--GENE TARGET OF THE ALL1 GENE IN ACUTE LEUKEMIAS
    Carlo Croce; Fiscal Year: 2002
    ..Acute lymphoblastic and acute myelogenous leukemias will be investigated for the expression, rearrangements and mutations of ALL-1 target genes. ..
  53. Jak/STAT signaling in human T-cell lymphomas
    Mariusz A Wasik; Fiscal Year: 2010
    ....
  54. ALL Fusion Proteins: Associated with Multi-protein Complexes and Role in Transcri
    Carlo M Croce; Fiscal Year: 2010
    ..abstract_text> ..