norepinephrine transporter

Summary

Gene Symbol: norepinephrine transporter
Description: solute carrier family 6 member 2
Alias: NAT1, NET, NET1, SLC6A5, sodium-dependent noradrenaline transporter, neurotransmitter transporter, norepinephrine transporter, solute carrier family 6 (neurotransmitter transporter), member 2, solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2, solute carrier family 6 member 5
Species: human

Top Publications

  1. pmc Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders
    H J Kim
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gut 53:829-37. 2004
  2. pmc The NH(2)-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells
    H H Gu
    Department of Pharmacology, Yale University, New Haven, CT 06510, USA
    Mol Biol Cell 12:3797-807. 2001
  3. ncbi Roles of transmembrane domain 2 and the first intracellular loop in human noradrenaline transporter function: pharmacological and SCAM analysis
    Sonja Sucic
    School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia
    J Neurochem 94:1620-30. 2005
  4. ncbi Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter
    T Pacholczyk
    Section of Molecular Neurobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510
    Nature 350:350-4. 1991
  5. ncbi Molecular cloning and organization of the coding region of the human norepinephrine transporter gene
    P Porzgen
    Institute of Pharmacology and Toxicology, University of Bonn, Germany
    Biochem Biophys Res Commun 215:1145-50. 1995
  6. ncbi Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter
    M Bruss
    Institut fur Pharmakologie und Toxikologie, Universitat Bonn, Germany
    Hum Genet 91:278-80. 1993
  7. ncbi The human noradrenaline transporter gene contains multiple polyadenylation sites and two alternatively spliced C-terminal exons
    P Porzgen
    Institut für Pharmakologie und Toxikologie der Universität Bonn, Reuterstrasse 2b, D 53113 Bonn, Germany
    Biochim Biophys Acta 1398:365-70. 1998
  8. ncbi Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1
    G E Torres
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 30:121-34. 2001
  9. ncbi The norepinephrine transporter gene and attention-deficit hyperactivity disorder
    Cathy L Barr
    Department of Psychiatry and Division of Cellular and Molecular Biology, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet 114:255-9. 2002
  10. ncbi Determinants within the C-terminus of the human norepinephrine transporter dictate transporter trafficking, stability, and activity
    Patricia A Bauman
    Department of Pharmacology and Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, TN 37232 6420, USA
    Arch Biochem Biophys 404:80-91. 2002

Research Grants

  1. Hot Flushes and SNPs of the Norepinephrine and Serotonin Transporter Genes
    ISTVAN JOZSEF MERCHENTHALER; Fiscal Year: 2012
  2. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2012
  3. Gamma-Synuclein-Mediated Regulation of Norepinephrine Transporter
    Anita Sidhu; Fiscal Year: 2010
  4. The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue
    ROBERT STANLEY SHERWIN; Fiscal Year: 2012
  5. Michael D Gershon; Fiscal Year: 2016
  6. MAARTEN E REITH; Fiscal Year: 2016
  7. DAVID HERLIE ROBERTSON; Fiscal Year: 2016
  8. Subramaniam Ananthan; Fiscal Year: 2014
  9. Neurobiological Correlates of Stress and Norepinephrine Transporter
    Meng Yang Zhu; Fiscal Year: 2012
  10. Imaging Adrenergic Stimulation of Brown Adipose Tissue
    Jogeshwar Mukherjee; Fiscal Year: 2012

Detail Information

Publications271 found, 100 shown here

  1. pmc Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders
    H J Kim
    Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Gut 53:829-37. 2004
    ..Our aims were: (1) to compare the prevalence of polymorphisms of alpha 2 (alpha(2)) adrenoceptors, norepinephrine transporter, and serotonin transporter protein (soluble carrier protein member 4 (SLC6A4)) promoter in patients with ..
  2. pmc The NH(2)-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells
    H H Gu
    Department of Pharmacology, Yale University, New Haven, CT 06510, USA
    Mol Biol Cell 12:3797-807. 2001
    ..cells, dopamine transporter (DAT) was detected predominantly in the apical plasma membrane, whereas norepinephrine transporter (NET) was found in the basolateral membrane, despite 67% overall amino acid sequence identity...
  3. ncbi Roles of transmembrane domain 2 and the first intracellular loop in human noradrenaline transporter function: pharmacological and SCAM analysis
    Sonja Sucic
    School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia
    J Neurochem 94:1620-30. 2005
    ..It was first necessary to establish a suitable background NET for SCAM...
  4. ncbi Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter
    T Pacholczyk
    Section of Molecular Neurobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510
    Nature 350:350-4. 1991
    ..identity with the Na+/gamma-aminobutyric acid transporter, thus identifying a new gene family for neurotransmitter transporter proteins...
  5. ncbi Molecular cloning and organization of the coding region of the human norepinephrine transporter gene
    P Porzgen
    Institute of Pharmacology and Toxicology, University of Bonn, Germany
    Biochem Biophys Res Commun 215:1145-50. 1995
    ..The organization of the gene is highly homologous to other known neurotransmitter transporter genes...
  6. ncbi Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter
    M Bruss
    Institut fur Pharmakologie und Toxikologie, Universitat Bonn, Germany
    Hum Genet 91:278-80. 1993
    ..2. In addition, evidence is presented for an intron-exon structure of the gene...
  7. ncbi The human noradrenaline transporter gene contains multiple polyadenylation sites and two alternatively spliced C-terminal exons
    P Porzgen
    Institut für Pharmakologie und Toxikologie der Universität Bonn, Reuterstrasse 2b, D 53113 Bonn, Germany
    Biochim Biophys Acta 1398:365-70. 1998
    ....
  8. ncbi Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1
    G E Torres
    Howard Hughes Medical Institute, Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 30:121-34. 2001
    ..These findings indicate a role for PDZ-mediated protein interactions in the localization, expression, and function of monoamine transporters...
  9. ncbi The norepinephrine transporter gene and attention-deficit hyperactivity disorder
    Cathy L Barr
    Department of Psychiatry and Division of Cellular and Molecular Biology, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Med Genet 114:255-9. 2002
    ..This study tested the gene for the norepinephrine transporter (NET1) as a susceptibility factor in ADHD using three polymorphisms located in exon 9, intron 9, and ..
  10. ncbi Determinants within the C-terminus of the human norepinephrine transporter dictate transporter trafficking, stability, and activity
    Patricia A Bauman
    Department of Pharmacology and Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, TN 37232 6420, USA
    Arch Biochem Biophys 404:80-91. 2002
    The function of the human norepinephrine transporter (hNET) depends on its presence at the cell surface...
  11. pmc Functional consequences of homo- but not hetero-oligomerization between transporters for the biogenic amine neurotransmitters
    A M Kocabas
    Department of Biochemistry and Molecular Biology, UAMS, Little Rock, Arkansas 72205, USA
    J Neurochem 85:1513-20. 2003
    Before this study, the human norepinephrine transporter (hNET) was the only member of the biogenic amine neurotransmitter transporter family that had not been demonstrated to be a functional homo-oligomer...
  12. ncbi A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters
    Maureen K Hahn
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 8548, USA
    J Neurosci 23:4470-8. 2003
    The norepinephrine transporter (NET) mediates reuptake of norepinephrine released from neurons, and, as such, it is an important regulator of noradrenergic neurotransmission...
  13. ncbi Association between norepinephrine transporter gene polymorphism and major depression
    Seung Ho Ryu
    Department of Psychiatry, Konkuk University College of Medicine, Seoul, Korea
    Neuropsychobiology 49:174-7. 2004
    ..It is suggested that the dysfunction of the norepinephrine transporter (NET) may be related to major depression...
  14. ncbi Association of norepinephrine transporter gene with methylphenidate response
    Li Yang
    Institute of Mental Health, Peking University, China
    J Am Acad Child Adolesc Psychiatry 43:1154-8. 2004
    This study aimed to explore the association between alleles of the norepinephrine transporter gene and the methylphenidate response.
  15. ncbi Prediction of antidepressant response to milnacipran by norepinephrine transporter gene polymorphisms
    Keizo Yoshida
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, USA
    Am J Psychiatry 161:1575-80. 2004
    ..The purpose of the present study was to determine whether norepinephrine transporter gene (NET) and serotonin transporter gene (5-HTT) polymorphisms are associated with the antidepressant ..
  16. ncbi Functional importance of the C-terminus of the human norepinephrine transporter
    Felix Distelmaier
    Institute of Pharmacology and Toxicology, University of Bonn, D 53113 Bonn, Germany
    J Neurochem 91:537-46. 2004
    Three C-terminal variants of the human norepinephrine transporter (hNET) are known: the wild-type hNET in which exon 14 encodes the last seven amino acids and two variants with either three or 18 amino acids encoded by an alternatively ..
  17. ncbi Positive association between T-182C polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a japanese population
    Kazuyuki Inoue
    Department of Pharmaceutical Science, Akita University Hospital, Akita, Japan
    Neuropsychobiology 50:301-4. 2004
    ..system appears to have a major impact on the symptomatology in major depressive disorder and the human norepinephrine transporter (NET) gene is one of the key candidates for genetic studies in major depressive disorder...
  18. ncbi Support for association between ADHD and two candidate genes: NET1 and DRD1
    Aaron J Bobb
    Child Psychiatry Branch, NIMH, NIH, Bethesda, Maryland 20892 1600, USA
    Am J Med Genet B Neuropsychiatr Genet 134:67-72. 2005
    ..Multiple candidate genes have been studied in ADHD, including the norepinephrine transporter (NET1) and dopamine D1 receptor (DRD1)...
  19. pmc C-terminal region regulates the functional expression of human noradrenaline transporter splice variants
    Chiharu Sogawa
    Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8525, Japan
    Biochem J 401:185-95. 2007
    The NET [noradrenaline (norepinephrine) transporter], an Na+/Cl--dependent neurotransmitter transporter, has several isoforms produced by alternative splicing in the C-terminal region, each differing in expression and function...
  20. pmc A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder
    Chun Hyung Kim
    Molecular Neurobiology, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 103:19164-9. 2006
    The norepinephrine transporter critically regulates both neurotransmission and homeostasis of norepinephrine in the nervous system...
  21. ncbi Response to methylphenidate in adults with ADHD is associated with a polymorphism in SLC6A3 (DAT1)
    J Sandra Kooij
    PsyQ, Psycho Medical Programs, The Hague, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:201-8. 2008
    ..conditions, and polymorphisms in the genes encoding the dopamine transporter, SLC6A3 (DAT1), the norepinephrine transporter, SLC6A2 (NET), and the dopamine receptor D4, DRD4...
  22. ncbi Norepinephrine transporter and catecholamine-O-methyltransferase gene variants and attention-deficit/hyperactivity disorder symptoms in adults
    W Retz
    Institute for Forensic Psychology and Psychiatry, Saarland University Hospital, Homburg, Germany
    J Neural Transm (Vienna) 115:323-9. 2008
    ..version of the WRAADDS, WRI) with haplotypes of the catechol-O-methyltransferase (COMT) and the norepinephrine transporter (SLC6A2) genes...
  23. doi Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1412-8. 2008
    ..Among the 102 available SNPs covering previously studied candidate genes, two SNPs within the norepinephrine transporter gene (NET, SLC6A2) were significant at P < or = 1 x 10(-2)...
  24. doi A haplotype of the norepinephrine transporter (Net) gene Slc6a2 is associated with clinical response to atomoxetine in attention-deficit hyperactivity disorder (ADHD)
    Nicolas Ramoz
    INSERM U675, IFR02, Faculty Xavier Bichat, University of Paris, Paris, France
    Neuropsychopharmacology 34:2135-42. 2009
    Atomoxetine is a specific inhibitor of the norepinephrine transporter (NET) that has demonstrated efficacy in the treatment of children with attention-deficit hyperactivity disorder (ADHD)...
  25. doi Lack of association between response of OROS-methylphenidate and norepinephrine transporter (SLC6A2) polymorphism in Korean ADHD
    Sung Hee Lee
    Department of Pharmacology, Yonsei University, Seoul, Republic of Korea
    Psychiatry Res 186:338-44. 2011
    ..between the five common polymorphisms (rs2242446, rs5568, rs5569, rs998424, and rs1616905) in the norepinephrine transporter (NET) gene and the OROS-methylphenidate response in a medication-naïve Korean attention-deficit ..
  26. pmc Possible association of norepinephrine transporter -3081(A/T) polymorphism with methylphenidate response in attention deficit hyperactivity disorder
    Boong Nyun Kim
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
    Behav Brain Funct 6:57. 2010
    ..Methylphenidate (MPH) has been shown to block the norepinephrine transporter (NET), and genetic investigations have demonstrated that the norepinephrine transporter gene (SLC6A2) is ..
  27. pmc The 1287 G/A polymorphism of the norepinephrine transporter gene (NET) is involved in commission errors in Korean children with attention deficit hyperactivity disorder
    Dong Ho Song
    Department of Child and Adolescent Psychiatry and Institute of Behavioral Science in Medicine, Severance Children s Hospital, Yonsei University College of Medicine, Seoul, South Korea
    Behav Brain Funct 7:12. 2011
    Previous evidence supports the role of noradrenergic systems in ADHD, and norepinephrine transporter (NET) is critical in regulating the noradrenergic system...
  28. doi No evidence for association between a functional promoter variant of the Norepinephrine Transporter gene SLC6A2 and ADHD in a family-based sample
    T J Renner
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Germany
    Atten Defic Hyperact Disord 3:285-9. 2011
    ..The norepinephrine transporter facilitates the reuptake of norepinephrine and dopamine in the prefrontal cortex and represents the main ..
  29. ncbi No evidence of linkage or association between the norepinephrine transporter (NET) gene polymorphisms and ADHD in the Irish population
    Brian McEvoy
    Am J Med Genet 114:665-6. 2002
  30. ncbi Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies
    B Bottalico
    Department of Obstetrics and Gynecology, Lund University Hospital, Klinikgatan, 221 85, Lund, Scania, Sweden
    Placenta 25:518-29. 2004
    ..we used in situ hybridization and real-time PCR to study the gene expression of monoamine transporters, such as NET, SERT, VMAT2, EMT and OCT1/2, in normal as well as in pre-eclamptic placentae...
  31. ncbi Noradrenaline transporter and its turnover rate are decreased in blood lymphocytes of patients with major depression
    S Mata
    Servicio de Psiquiatria, Hospital Vargas, Caracas, Venezuela
    J Neuroimmunol 170:134-40. 2005
    ....
  32. ncbi Further evidence of association between two NET single-nucleotide polymorphisms with ADHD
    J W Kim
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mol Psychiatry 13:624-30. 2008
    The norepinephrine transporter (NET) gene is an attractive candidate gene for attention-deficit hyperactivity disorder (ADHD)...
  33. doi No evidence of an association between norepinephrine transporter gene polymorphisms and attention deficit hyperactivity disorder: a family-based and case-control association study in a Korean sample
    Soo Churl Cho
    Department of Child and Adolescent Psychiatry, College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Neuropsychobiology 57:131-8. 2008
    ..Previous studies have demonstrated that the norepinephrine transporter gene (SLC6A2) is associated with ADHD...
  34. doi Functional gene variation in the human norepinephrine transporter: association with attention deficit hyperactivity disorder
    Chun Hyung Kim
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, 115 Mill St, Belmont, MA 02478, USA
    Ann N Y Acad Sci 1129:256-60. 2008
    The norepinephrine (NE) transporter (NET) is responsible for the re-uptake of NE into presynaptic nerve terminals, thus critically regulating noradrenergic signaling and homeostasis...
  35. pmc SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families
    S H Kollins
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1580-8. 2008
    ..errors and SNPs in the DRD2 gene (rs2075654, rs1079596), and between reaction time variability and a SNP in the NET gene (rs3785155)...
  36. doi Association studies of -3081(A/T) polymorphism of norepinephrine transporter gene with attention deficit/hyperactivity disorder in Korean population
    Yoosook Joung
    Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Am J Med Genet B Neuropsychiatr Genet 153:691-4. 2010
    ..It is revealed that the norepinephrine transporter gene (SLC6A2) is a possible candidate gene directly related to ADHD...
  37. pmc A candidate gene analysis of methylphenidate response in attention-deficit/hyperactivity disorder
    James J McGough
    Semel Institute for Neuroscience and Human Behavior and David Geffen School of Medicine, University of California, Los Angeles, USA
    J Am Acad Child Adolesc Psychiatry 48:1155-64. 2009
    ..This study examines the potential role of candidate genes in moderating treatment effects of methylphenidate (MPH) in attention-deficit/hyperactivity disorder (ADHD)...
  38. ncbi Alterations in angiotensin II release and vascular reactivity in hypertensive men: a pilot study
    S Gasic
    Department of Medicine III, Institute of Medical and Laboratory Diagnostics, University of Vienna, Austria
    Am J Hypertens 12:1055-62. 1999
    ..2+/-5.8 years) and 12 normotensive (N; 29.1+/-4.6 years) men in two separate trials. Net transfemoral balance of AII and of ET-1 was calculated from the respective Arterio-Venous (A-V) differences in ..
  39. ncbi Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group
    S Hulley
    University of California, San Francisco 94143, USA
    JAMA 280:605-13. 1998
    ..99; 95% confidence interval [CI], 0.80-1.22). The lack of an overall effect occurred despite a net 11% lower low-density lipoprotein cholesterol level and 10% higher high-density lipoprotein cholesterol level in ..
  40. ncbi Age-related changes in interstitial norepinephrine. A microdialysis study in spontaneously hypertensive rats
    A Cabassi
    Institute of Clinical Medicine and Nephrology, University of Parma Medical School, Italy
    Am J Hypertens 9:878-83. 1996
    ..0 pg/mL v 541.4 pg/mL; P < .001) and a blunted response to TYR challenge. The net output, estimated by subtracting basal values, was 86.0 pg NE/h in SHR as compared to 212.5 pg NE/ h in WKY (P = ...
  41. ncbi Regional adipose tissue metabolism in postmenopausal women after treatment with exogenous sex steroids
    U B Lindberg
    Department of Obstetrics and Gynecology, Medicine I, Sahlgrenska Hospital, , Sweden
    Horm Metab Res 22:345-51. 1990
    ..ethinyl estradiol (EE) was investigated given orally alone and in combination with 10 mg norethisterone acetate (NET). This combination is reminiscent of an old high dose oral contraceptive...
  42. pmc Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators, PDR1 and PDR3
    L S Kean
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Cell Biol 138:255-70. 1997
    ..in both mutant strains increased four- to fivefold relative to the parent Tpe+ strain, indicating that the net inward flux of endogenous phosphatidylethanolamine as well as M-C6-NBD-PE was decreased...
  43. ncbi Ketone body utilization for lipogenesis in the perfused liver of the obese Zucker rat
    M J Azain
    Cardiovascular Biology, Oklahoma Medical Research Foundation, Oklahoma City
    Horm Metab Res 22:561-5. 1990
    ..5 mumols in the lean rat livers and 42.0 mumoles in the obese (P less than 0.025). The net increase was 35 mumoles incorporated, whereas the net decrease in ketogenesis was 284 mumoles...
  44. ncbi Stereochemical determinants of the nature and consequences of drug metabolism
    J Caldwell
    Department of Pharmacology and Toxicology, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK
    J Chromatogr A 694:39-48. 1995
    ..There now an enormous number of examples of each of these possibilities. The net result of the interaction of the stereoselectivities of these various processes can obscure the fact that one (or ..
  45. ncbi Xanthine oxidase and xanthine dehydrogenase from an estivating land snail
    M Hermes Lima
    Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada
    Z Naturforsch C 50:685-94. 1995
    ..Compared with hepatopancreas catalase, XO activity is probably too low to contribute significantly to the net generation of oxyradicals, and hence to peroxidative damage...
  46. ncbi Removal of endotoxins by affinity sorbents
    F B Anspach
    GBF-National Research Centre for Biotechnology, Braunschweig, Germany
    J Chromatogr A 711:81-92. 1995
    ..Endotoxin removal from protein solutions depended on the net charge of the desired protein. Lysozyme as a model for positively charged proteins enhanced endotoxin removal...
  47. pmc Assessment of renal dopaminergic system activity in the nitric oxide-deprived hypertensive rat model
    P Soares da Silva
    Institute of Pharmacology and Therapeutics, Faculty of Medicine, Porto, Portugal
    Br J Pharmacol 114:1403-13. 1995
    ..The application of the Michaelis-Menten equation to the net transport of newly-formed dopamine allowed the identification of a saturable (carrier-mediated transfer) and a non-..
  48. pmc Influence of physician specialty on adoption and relinquishment of calcium channel blockers and other treatments for myocardial infarction
    S R Majumdar
    Division of General Internal Medicine, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Gen Intern Med 16:351-9. 2001
    ..66 to 1.31). From 1992--1993 to 1995--1996, the use of CCBs in patients with AMI decreased from 24% to 10%, the net result of physicians starting CCBs less often and discontinuing them more often...
  49. ncbi Capillary electrophoretic separation of cationic porphyrins
    D W Dixon
    Department of Chemistry, Georgia State University, Atlanta 30303, USA
    J Chromatogr A 802:367-80. 1998
    ..b>Net charge, molecular mass and molecular shape all contribute to the differential retention of cationic porphyrins ..
  50. pmc Effects of selective ETB-receptor stimulation on arterial, venous and capillary functions in cat skeletal muscle
    U Ekelund
    Department of Physiology and Biophysics, University and University Hospital of Lund, Sweden
    Br J Pharmacol 112:887-94. 1994
    ..increase, and the constrictor response with a sustained decrease, in capillary pressure, the latter causing net transcapillary fluid absorption...
  51. ncbi Estimation of trunk muscle forces and spinal loads during fatiguing repetitive trunk exertions
    P J Sparto
    Biomedical Engineering Center, Ohio State University, Columbus, USA
    Spine (Phila Pa 1976) 23:2563-73. 1998
    ..repetitive isokinetic trunk extension endurance tests at two load levels and two repetition rates, while their net muscular torque output and trunk muscular activity were measured...
  52. ncbi Effect of streptolysin-O-on rat hepatic acetyl coenzyme-A: arylamine N-acetyltransferase and cytochrome P-450 2B 1/2 activities ex vivo
    R K Drobitch
    Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI, 48202, USA
    Immunopharmacol Immunotoxicol 20:159-71. 1998
    ..of rats on cytochrome P-450-catalyzed tolbutamide hydroxylation and NAT activities toward PA (a substrate for NAT1), and p-aminobenzoic acid (a substrate for NAT2) was examined ex vivo. Subacute SLO (SIGMA Chemical Company, St...
  53. ncbi Spatial and temporal performance of the miniface (free air CO2 enrichment) system on Bog Ecosystems in northern and Central Europe
    F Miglietta
    IATA-CNR, Institute of Agrometeorology and Environmental Analysis, National Research Council, P. le delle Cascine 18, 50144 Firenze, Italy
    Environ Monit Assess 66:107-27. 2001
    ..at five climatically different sites across Europe, the effects of elevated CO2 and N deposition on the net exchange of CO2 and CH4 between bogs and the atmosphere, and to study the effects of elevated CO2 and N deposition ..
  54. doi Regulation of the neuronal norepinephrine transporter by endothelin-1 and -3 in the rat anterior and posterior hypothalamus
    Sandra I Hope
    Cátedra de Fisiología e Instituto de Química y Metabolismo del Fármaco, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Neurochem Int 53:207-13. 2008
    ..Neither endothelin-1 nor endothelin-3 modified neuronal norepinephrine transporter K(d) in the studied hypothalamic regions...
  55. ncbi Cold-acclimation-induced protein hypertrophy in channel catfish and green sunfish
    J Kent
    Department of Physiology and Biophysics, University of Illinois, Urbana 61801
    J Comp Physiol B 158:185-98. 1988
    ..However, sunfish showed a net increase in total liver protein content and an increase in protein concentration...
  56. ncbi Regression of atherosclerosis. A role for calcium antagonists
    M L Armstrong
    Cardiovascular Center, University of Iowa College of Medicine, Iowa City 52242
    Am J Hypertens 4:503S-511S. 1991
    The key processes responsible for plaque in atherosclerosis are cholesterol accumulation, caused by increased net uptake of atherogenic lipoproteins; cell proliferation and recruitment, caused by mitogenic and chemotactic activity; ..
  57. pmc Effects of tenoxicam and aspirin on the metabolism of proteoglycans and hyaluronan in normal and osteoarthritic human articular cartilage
    D H Manicourt
    Saint Luc University Hospital, University of Louvain, Brussels, Belgium
    Br J Pharmacol 113:1113-20. 1994
    ..PG metabolism whereas it reduced HA synthesis in a dose-dependent manner and did not change or even increased the net loss of [3H]-HA...
  58. ncbi Diltiazem inhibition of sodium-induced calcium release. Effects on energy metabolism of heart mitochondria
    M A Matlib
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, OH 45267-0575
    Am J Hypertens 4:435S-441S. 1991
    ..process was not blocked, the progressive inhibition of sodium-induced calcium release by diltiazem resulted in a net gain of calcium by mitochondria in vitro, suggesting that a similar effect in vivo may increase intramitochondrial ..
  59. pmc A cost-benefit analysis of a California county's back injury prevention program
    L Shi
    Department of Health Administration, School of Public Health, University of South Carolina, Columbia 29208
    Public Health Rep 108:204-11. 1993
    ..Cost-benefit analysis showed the net benefit of introducing back injury prevention program was $161,108, and the return on investment is 179 percent...
  60. pmc Ca2+ increase and Ca(2+)-influx in human tracheal smooth muscle cells: role of Ca2+ pools controlled by sarco-endoplasmic reticulum Ca(2+)-ATPase 2 isoform
    Y Amrani
    INSERM U 425, , Illkirch, France
    Br J Pharmacol 115:1204-10. 1995
    ..b>Net increases of 60 +/- 9, 150 +/- 22 and 210 +/- 27 nM were obtained after 1, 3 and 5 min, respectively. 3...
  61. pmc A community-based study of subclinical flavivirus infections in children in an area of Tamil Nadu, India, where Japanese encephalitis is endemic
    A Gajanana
    Centre for Research in Medical Entomology, Chinna Chokkikulam, Madurai, India
    Bull World Health Organ 73:237-44. 1995
    ..The average net annual increase of 16...
  62. pmc Cross-linking myosin subfragment 1 Cys-697 and Cys-707 modifies ATP and actin binding site interactions
    K Kirshenbaum
    Department of Biochemistry, University of the Pacific School of Dentistry, San Francisco, California 94115 2399
    Biophys J 65:1121-9. 1993
    ..actin affinity of pPDM-S1 is over 6,000-fold lower than that of S1, and the absolute value of the product of the net effective electric charges at the acto-S1 interface is reduced from 8.1 esu2 for S1 to 1.6 esu2 for pPDM-S1...
  63. ncbi Pharmacoeconomics: what is it and where is it going?
    J S McCombs
    University of Southern California School of Pharmacy, Pharmaceutical Economics and Policy, Los Angeles 90033, USA
    Am J Hypertens 11:112S-119S; discussion 135S-137S. 1998
    ..analysis, which compares the clinical effects of alternative therapies (mortality, morbidity) to their net costs...
  64. pmc Decision analysis model of prolonged oral anticoagulant treatment in factor V Leiden carriers with first episode of deep vein thrombosis
    F P Sarasin
    Medical Clinics, Hospital Cantonal, University of Geneva Medical School, Switzerland
    BMJ 316:95-9. 1998
    ..CONCLUSION: The lack of evidence of a net clinical benefit of prolonged oral anticoagulation, at least beyond 1 year, among patients recovering from acute ..
  65. pmc Influenza immunization in a managed care organization
    A M Baker
    Center for Clinical Effectiveness, Henry Ford Health System, Detroit, Mich 48202, USA
    J Gen Intern Med 13:469-75. 1998
    ..The cost-effectiveness analysis estimated that in a nonepidemic year, the net savings per 100 reminders sent would be $659 for the personalized postcard intervention and $735 for the tailored ..
  66. ncbi Levonorgestrel and norethindrone alter insulin action on skeletal muscle of the female rat
    S R Hager
    Department of Medicine, Medical College of Wisconsin, Milwaukee
    Horm Metab Res 22:265-8. 1990
    ..01) but the net suppression below baseline was similar in the control and steroid-treated groups...
  67. ncbi [Tuberculosis and radiologic diagnosis 100 years after W. C. Roentgen]
    R Felix
    Strahlenklinik und Poliklinik, Virchow-Klinikum,
    Pneumologie 49:657-62. 1995
    ..Digital radiography and digital net-work allow for x-rays at the lowest dose, improved comparison in the follow-up, as well as for "online"-evaluation ..
  68. ncbi Should the gap be filled between guidelines and actual practice for management of low back pain in primary care? The Quebec experience
    M Rossignol
    Centre for Clinical Epidemiology and Community Studies, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    Spine (Phila Pa 1976) 21:2893-8; discussion 2898-9. 1996
    ..A prospective cohort study...
  69. ncbi New angiotensin converting enzyme inhibitors. Their role in the management of hypertension
    J H Laragh
    Cardiovascular Center, New York Hospital-Cornell Medical Center, New York City 10021
    Am J Hypertens 3:257S-265S. 1990
    ..The net effect is improved blood flow and reduced cardiac work...
  70. ncbi [Observation of Pseudomonas aeruginosa biofilm with confocal laser scanning microscope]
    T Watanabe
    Department of Urology, Okayama University Medical School
    Kansenshogaku Zasshi 69:114-22. 1995
    ..5, pH 7.5, pH 9.5). Only extracellular matrix was stained as a net-like structure for FITC-ConA and only bacteria for acridine orange and safranine...
  71. ncbi Interrelation between cyanophycin synthesis, L-arginine catabolism and photosynthesis in the cyanobacterium Synechocystis sp. strain PCC 6803
    D P Stephan
    Biologie 1 Morphologie der Pflanzen und Feinbau der Zelle, , Germany
    Z Naturforsch C 55:927-42. 2000
    ..Thus, net cyanophycin accumulation in Synechocystis PCC 6803 is regulated by the relative concentration of L-arginine to the ..
  72. ncbi Energy-dependent flip of fluorescence-labeled phospholipids is regulated by nutrient starvation and transcription factors, PDR1 and PDR3
    P K Hanson
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 276:9861-7. 2001
    ..The net intracellular accumulation reflects the sum of their inwardly and outwardly directed transbilayer translocation ..
  73. ncbi Beyond blood pressure control. Effect of antihypertensive therapy on cardiovascular risk factors
    M H Maxwell
    UCLA School of Medicine, Los Angeles, CA 90024
    Am J Hypertens 1:366S-371S. 1988
    ..and beta-blockers may be partially offsetting the beneficial effects of blood pressure reduction, with the net result being a failure of these agents to reduce the risk of CHD...
  74. ncbi Absorption of short-chain fatty acids across ruminal epithelium of sheep
    T Kramer
    University of Leipzig, Department of Veterinary Biochemistry, Germany
    J Comp Physiol B 166:262-9. 1996
    ..1 mmol.l-1) or mucosal nitrate (40 mmol.l-1) markedly reduced propionate net flux (in vitro)...
  75. ncbi Effects of endotoxins from Bacteroides intermedius and Escherichia coli on human monocytes in vitro
    B Johne
    Institute of Microbiology, Dental Faculty, University of Oslo, Norway
    Acta Pathol Microbiol Immunol Scand C 95:241-50. 1987
    ..on different aspects of human monocytes vary considerably; they also suggest that the balance between stimulatory and suppressive properties of a particular endotoxin may influence its net effect on mononuclear phagocyte functions.
  76. ncbi Modulation of DNA and protein adducts in smokers by genetic polymorphisms in GSTM1,GSTT1, NAT1 and NAT2
    R W Godschalk
    Department of Health Risk Analysis and Toxicology, Maastricht University, Maastricht, The Netherlands
    Pharmacogenetics 11:389-98. 2001
    ..Genetic polymorphisms in glutathione S-transferase M1 (GSTM1), T1 (GSTT1) and N-acetyl-transferase 1 (NAT1) and 2 (NAT2) were assessed by polymerase chain reaction-based methods...
  77. ncbi Norepinephrine transporter mRNA expression after coitus in the rabbit brainstem
    J Bao
    Division of Reproductive Sciences, Oregon Regional Primate Research Center, Oregon Health and Science University, Beaverton 97006, USA
    Chin J Physiol 44:103-10. 2001
    ..tyrosine hydroxylase (TH, the rate-limiting enzyme for NE synthesis) and/or decreasing the activity of norepinephrine transporter (NET, the key protein for NE re-uptake)...
  78. ncbi Energy metabolism in potoroine marsupials
    I R Wallis
    Department of Biochemistry, Microbiology and Nutrition, University of New England, Armidale, NSW, Australia
    J Comp Physiol B 162:478-87. 1992
    ..kg-0.75.day-1) were 479, 494 and 345 for P. tridactylus, B. penicillata and A. rufescens, respectively. The net availability of metabolisable energy was about 0.70 in the three species...
  79. ncbi Gestational changes in electrolyte transport, electrical activity, and permeability of the porcine placenta
    G E Rice
    Department of Physiology, Monash University, Clayton, Australia
    J Comp Physiol B 161:189-98. 1991
    ..b>Net transmural transport of 22Na and 36Cl across sections of porcine allantochorion-endometrium (ALCE), amniochorion-..
  80. ncbi A comparative study of costs for dental services and dentists' income in the United States and Norway
    L A Heloe
    Institute of Community Dentistry, University of Oslo, Norway
    Community Dent Oral Epidemiol 22:65-70. 1994
    ..4%. A higher percentage of Norwegian adults see a dentist annually as compared to US adults. In 1984, the mean net income of dentists in private practice was $66,940 in the US and $27,125 in Norway; this is respectively 5 and 1 3/..
  81. ncbi Development of an indicator to evaluate the impact, on a community-based Aedes aegypti control intervention, of improved cleaning of water-storage containers by householders
    A S Chan
    Department of International Health, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Ann Trop Med Parasitol 92:317-29. 1998
    ..and fourth-instar larvae in washbasins by taking five dips (quick immersions to a standard depth) with a hand-held net was found to be sufficient for estimating the true population size of that same cohort...
  82. ncbi Reduced 125I-meta-iodobenzylguanidine uptake and norepinephrine transporter density in the hearts of mice with MPTP-induced parkinsonism
    Nobuyoshi Fukumitsu
    Proton Medical Research Center, University of Tsukuba, Ibaragi, Japan
    Nucl Med Biol 33:37-42. 2006
    ..Cardiac concentrations of norepinephrine transporter (NET) were measured in three groups of twenty 15-week-old C57BL6 mice receiving these same treatments...
  83. ncbi Heat increment of feeding and its thermoregulatory benefit in the muskrat (Ondatra zibethicus)
    R A Macarthur
    Department of Zoology, University of Manitoba, Winnipeg, Canada
    J Comp Physiol B 164:141-6. 1994
    ..Our data did not support the hypothesis that heat increment of feeding retards body cooling in water. Net body temperature decline in water was actually higher in fed animals than in fasted controls...
  84. ncbi A prospective, one-year study on the effects of two long acting injectable contraceptives (depot-medroxyprogesterone acetate and norethisterone oenanthate) on serum and lipoprotein lipids
    L Enk
    Department of Obstetrics and Gynecology, Sahlgrenska Hospital, , Sweden
    Horm Metab Res 24:85-9. 1992
    ..administered progestins (depot medroxyprogesterone acetate, DMPA, 150 mg/12 weeks and norethisterone oenanthate, NET, 200 mg/8 weeks respectively) were given to women seeking contraceptive advice...
  85. ncbi Predictors of breast cancer screening in a panel study of African American women
    B A Husaini
    Center for Health Research, Tennessee State University, Nashville 37209, USA
    Women Health 34:35-51. 2001
    ..In contrast, depression significantly reduces the odds of getting a mammogram. Family histories of breast cancer and church participation have no effect on rates of mammography net of other factors.
  86. pmc Global eradication of poliomyelitis: benefit-cost analysis
    K J Bart
    Office of International Health, Department of Health, and Human Services DHHS Rockville, MD 20878, USA
    Bull World Health Organ 74:35-45. 1996
    ..The base case examined the net costs and benefits during the period 1986-2040; the model assumed differential costs for oral poliovirus vaccine (..
  87. pmc Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR
    W Xie
    Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Genes Dev 14:3014-23. 2000
    ..activation of multiple CYP gene classes by certain xenobiotics, but also reveal the existence of a metabolic safety net that confers a second layer of protection to the harmful effects of toxic compounds and at the same time increases ..
  88. ncbi Outcome measures in split mouth caries trials and their statistical evaluation
    P J Riordan
    Dental Services, Dental School, University of Western Australia, Perth
    Community Dent Oral Epidemiol 22:192-7. 1994
    ..the outcome measures used in split mouth trials have been material retention, (per cent) effectiveness and net gain...
  89. ncbi Assessment of joint review of radiologic studies by a primary care physician and a radiologist
    B C Knollmann
    Department of Medicine, Georgetown University Medical Center, Washington, DC, USA
    J Gen Intern Med 11:608-12. 1996
    ..The cost for extra physician time was $5,499. Thus, the review process incurred a net cost of $3,532...
  90. pmc Conditional immortalization of human thyroid epithelial cells: a tool for analysis of oncogene action
    D Wynford-Thomas
    Department of Pathology, University of Wales, College of Medicine, Health Park, Cardiff, United Kingdom
    Mol Cell Biol 10:5365-77. 1990
    ..Interestingly, this was associated with a marked reduction in net growth rate. At the restrictive temperature, induction of mutant ras caused rapid cell death...
  91. pmc Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro
    B Driessen
    , Abteilung Pharmakologie, Aachen, Germany
    Br J Pharmacol 108:806-11. 1993
    ..The interaction with the noradrenaline transporter is stereoselective. The principal metabolite O-desmethyltramadol shows in addition to noradrenaline uptake inhibition, opioid inhibition of noradrenaline release...
  92. ncbi Active calcium ion transport Xenopus laevis skin
    S M Guirguis
    Biological Sciences Department, California State Polytechnic University, Pomona 91768, USA
    J Comp Physiol B 167:328-34. 1997
    ..Efflux is relatively constant at external concentrations between 0.016 and 0.6 mmol.l-1; net flux which is negative below 0.125 mmol.l-1 becomes positive above this external [Ca2+]...
  93. ncbi Sleep-disordered breathing and cardiovascular disease: epidemiologic evidence for a relationship
    T Young
    University of Wisconsin-Madison, 53705, USA
    Sleep 23:S122-6. 2000
    ..g., from inadequate control of confounders and improper comparison groups), and the net magnitude of competing biases undoubtedly varies from study to study...
  94. pmc "I can't afford that!": dilemmas in the care of the uninsured and underinsured
    S Weiner
    Section of General Internal Medicine, Department of Medicine, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612-7323, USA
    J Gen Intern Med 16:412-8. 2001
    ..face when patients cannot pay for needed medical services: (1) whether to refer the individual to a safety net provider, such as a public clinic; (2) whether to forgo indicated tests and therapies because of cost; and (3) ..
  95. ncbi Imaging the norepinephrine transporter in humans with (S,S)-[11C]O-methyl reboxetine and PET: problems and progress
    Jean Logan
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Nucl Med Biol 34:667-79. 2007
    ..with the PET radiotracer (S,S)-[(11)C]O-methyl reboxetine ([(11)C](S,S)-MRB), a ligand targeting the norepinephrine transporter (NET), are reported...
  96. pmc Risk of vaccine-associated paralytic poliomyelitis in Latin America, 1989-91
    J K Andrus
    Expanded Programme on Immunization, WHO Regional Office for South East Asia, New Delhi, India
    Bull World Health Organ 73:33-40. 1995
    ..4 million doses administered in England and Wales (1985-91) and with one case per 2.5 million net doses distributed in the USA (1980-89)...
  97. pmc Anti-inflammatory and analgesic activity of the bradykinin antagonist, icatibant (Hoe 140), against an extract from Porphyromonas gingivalis
    T Griesbacher
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Br J Pharmacol 112:1004-6. 1994
    ..1 and 1.0 mg) caused a dose-dependent oedema of the hind paws. The net increase of the paw volume 60 min after the injection was 23 +/- 5% and 77 +/- 12%, respectively...
  98. ncbi Entomological evaluation of the Gambia's National Impregnated Bednet Programme
    M C Thomson
    Medical Research Council Laboratories, Fajara, Banjul, The Gambia
    Ann Trop Med Parasitol 89:229-41. 1995
    ..in area II, where the treated village was relatively isolated and 74% of the population slept under a treated net. Anopheles gambiae s.l...
  99. ncbi Applications of new liquid chromatography-tandem mass spectrometry technologies for drug development support
    L Yang
    Schering-Plough Research Institute, Kenilworth, NJ 07033-1300, USA
    J Chromatogr A 926:43-55. 2001
    ..5 to 0.35 min, resulting in a net acquisition time of 11 s. Four simulated validation runs with standard and quality control solutions were analyzed...
  100. pmc Nutritional status of Brazilian children: trends from 1975 to 1989
    C A Monteiro
    Department of Nutrition, School of Public Health, , Brazil
    Bull World Health Organ 70:657-66. 1992
    ..Trends in family income indicate extraordinary economic gains in the 1970s, some losses in the 1980s, and a modest net gain over the period 1975-89...
  101. ncbi Effect of fluoride in amalgam on secondary caries incidence
    L Skartveit
    Department of Oral Radiology, University of Bergen, Norway
    Community Dent Oral Epidemiol 22:122-5. 1994
    ..I. 24.4%, 57.1%) and the net gain 10.3% (95% C.I. 4.75%, 16.3%). The relative risk was 0.570 (95% C.I. 0.444%, 0.731%)...

Research Grants63

  1. Hot Flushes and SNPs of the Norepinephrine and Serotonin Transporter Genes
    ISTVAN JOZSEF MERCHENTHALER; Fiscal Year: 2012
    ..response is due to single nucleotide polymorphisms of the serotonin transporter (SERT) and/or the norepinephrine transporter (NET) genes...
  2. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2012
    ..metabolism (apolipoprotein E), neurotransmitter metabolism (dopamine transporter, dopamine D4 receptor, norepinephrine transporter, monoamine oxidase, catechol O-methyltransferase, NMDA receptor, 5-HT1A receptor), and methylation ..
  3. Gamma-Synuclein-Mediated Regulation of Norepinephrine Transporter
    Anita Sidhu; Fiscal Year: 2010
    ..We have shown that .-Syn can modulate the function and trafficking of the NE transporter [NET], through interactions with the microtubule [MT] cytoskeleton...
  4. The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue
    ROBERT STANLEY SHERWIN; Fiscal Year: 2012
    ..of the sympathetic nervous system, and image the norepinephrine recycling component, designated the norepinephrine transporter (NET)...
  5. Michael D Gershon; Fiscal Year: 2016
    ..which are among the first to born in the ENS, are transiently catecholaminergic (TC) and express the norepinephrine transporter (NET). Genetic NET deletion (NETKO) interferes with development of enteric serotonergic neurons...
  6. MAARTEN E REITH; Fiscal Year: 2016
    ..Other biogenic amine transporters are the serotonin transporter (SERT) and the norepinephrine transporter (NET), targets for many different antidepressant drugs...
  7. DAVID HERLIE ROBERTSON; Fiscal Year: 2016
    ..as (1) familial dysautonomia (2) dopamine beta-hydroxylase deficiency, (3) baroreflex failure, and (4) norepinephrine transporter deficiency...
  8. Subramaniam Ananthan; Fiscal Year: 2014
    ..Selected promising ligands will be evaluated against serotonin transporter (SERT) and norepinephrine transporter (NET) to ascertain their transporter target selectivity...
  9. Neurobiological Correlates of Stress and Norepinephrine Transporter
    Meng Yang Zhu; Fiscal Year: 2012
    ..These hormones affect many brain areas functionally and structurally. Norepinephrine transporter is a key protein in the brain and is related to the function of the noradrenergic system which controls ..
  10. Imaging Adrenergic Stimulation of Brown Adipose Tissue
    Jogeshwar Mukherjee; Fiscal Year: 2012
    ..of BAT using the rodent model by using a [unreadable]3-adrenoreceptor agonist, CL 316243 and the norepinephrine transporter (NET) blocker, tomoxetine...
  11. Structural and Mechanistic Characterization of Neurotransmitter Reuptake Inhibiti
    DANENG WANG; Fiscal Year: 2012
    ..These proteins include the serotonin transporter (SERT), norepinephrine transporter (NET) and dopamine transporter (DAT)...
  12. The Norepinephrine Transporter as a Novel Target for a Bone Anabolic Treatment
    Florent Elefteriou; Fiscal Year: 2013
    ..Anti-depressants, depending on their selectivity, target the serotonin transporter (SERT) or the norepinephrine transporter (NET) in neurons...
  13. Development of transporter targeted platinum drugs for neuroblastoma
    Richard D Mamelok; Fiscal Year: 2012
    ..Neuroblastoma has a high level of expression of the norepinephrine transporter (NET), an influx transporter responsible for accumulating norepinephrine in neuroendocrine cells...
  14. Mechanism of drug addiction
    Howard H Gu; Fiscal Year: 2013
    ..has 3 high affinity targets in the brain, dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET)...
  15. PET Imaging Tracers to Quantify Norepinephrine Transporter in the Brain
    John M Gerdes; Fiscal Year: 2010
    ..The norepinephrine transporter (NET) is an integral membrane protein responsible for transport of NE into the presynaptic terminal...
  16. Sammanda Ramamoorthy; Fiscal Year: 2016
    ..three major placental drug transporters: P-glycoprotein (P-gp), the serotonin transporter (SERT) and the norepinephrine transporter (NET);2) assess the functional activity of placental transporters across gestation using placental ..
  17. Youngho Seo; Fiscal Year: 2016
    ..MIBG is taken up by sympathetic neurons via a specific norepinephrine transporter (NET) and 90% of all neuroblastoma tumors are MIBG-avid...
  18. Spinal Noradrenergic Sprouting after Nerve Injury
    James Eisenach; Fiscal Year: 2012
    ..spinal acetylcholine release for analgesia after nerve injury, this pathway could be augmented by norepinephrine transporter and cholinesterase inhibitors...
  19. Thalamic Processes of Self Control in Cocaine Dependence
    Chiang Shan Ray Li; Fiscal Year: 2010
    ..resonance imaging (fMRI) during a stop signal task (SST) and positron tomography (PET) imaging of the norepinephrine transporter (NET) to examine the thalamic processes of self control in PCD...
  20. New PET ligands for brain serotonin transporter in neuropsychiatric disorders
    Nashwa Jarkas; Fiscal Year: 2012
    ..containing candidates in transfected cells stably expressing the human dopamine transporter (DAT), norepinephrine transporter (NET), or SERT, and (3) microPET studies defining time-activity curves (TAC) for specific and ..
  21. CELLULAR TARGETS FOR ABUSABLE DRUGS IN HUMAN PLACENTA
    Vadivel Ganapathy; Fiscal Year: 1999
    ..Human placenta expresses the serotonin transporter and the norepinephrine transporter, both of which are targets for cocaine and/or amphetamines...
  22. REGULATION OF THE HUMAN NOREPINEPHRINE TRANSPORTER
    Gregory Ordway; Fiscal Year: 2002
    DESCRIPTION (from applicant's abstract): The human norepinephrine transporter (hNET) is a high affinity binding site for many psychotherapeutic compounds, including those with antidepressant efficacy (e.g. tricyclic antidepressants)...
  23. Neurobehavioral Analysis of Norepinephrine Transporter Variants
    Maureen K Hahn; Fiscal Year: 2010
    ..The application will provide novel training in the area of transgene expression of norepinephrine transporter genetic variants in primary noradrenergic neuronal culture and genetically altered mice, including use ..
  24. Genetic polymorphisms in 5'-UTR of human NAT1 and NAT2
    Anwar Husain; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): This project will characterize the minimal promoter region of human NAT1 and NAT2 and study effects of genetic polymorphisms on expression in human mammary cells...
  25. Guang Ping Gao; Fiscal Year: 2016
    ..NAA is synthesized in the mitochondria of neurons by N-acetyltransferase (NAT1) and hydrolyzed in oligodendrocytes (OLs) by ASPA...
  26. MECHANISMS OF SYMPATHETIC NEURON SPECIFICATION
    Maya Sieber Blum; Fiscal Year: 2004
    ..receptor, p75NTR and the neurotrophin-3 (NT-3)-selective receptor, TrkC, sympathetic neurons express the norepinephrine transporter (NET), tyrosine hydroxylase (TH), dopamine-~-hydroxylase (DBH), the nerve growth factor-selective ..
  27. Mechanism of mitotic exit in budding yeast
    Raymond Deshaies; Fiscal Year: 2009
    ..exit from mitosis is the activation of Cdc14, which is achieved by its release from the nucleolar anchor protein Net1. Thus, a key to understanding how cells exit mitosis is to understand how Cdc14 is mobilized from the nucleolus at ..
  28. ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISM
    Stephen Schwartz; Fiscal Year: 2001
    ..EPHX), cytochrome p450 2E1 (CYP2E1), alcohol dehydrogenase type 3 (ADH3), N-acetyltransferase types 1 and 2 (NAT1, NAT2), and NAD(P)H:quinone oxidoreductase (NQ01)...
  29. Pharmacogenetics of sulfamethoxazole in HIV/AIDS patients
    Danxin Wang; Fiscal Year: 2009
    ..Several pathways determine SMX hypersensitivity: Metabolic inactivation by N-acetyltransferases 1 and 2 (NAT1 and NAT2);metabolic oxidation to toxic hydroxylamine derivatives by CYP2C9 and other (extra-) hepatic enzymes;..
  30. GENE-ENVIRONMENT EFFECTS AND COLON ADENOMAS
    Henry Lin; Fiscal Year: 2000
    ..The project will characterize polymorphic genes for NAT1, NAT2, GSTM1, GSTM3, GSTT1, PGHS-1, PGHS-2, and cPLA2 in all subjects...
  31. ALPHA-2 ADRENERGIC CONTROL OF COLONIC FUNCTION IN IBS
    Michael Camilleri; Fiscal Year: 2007
    ..of gut function; and 3) polymorphisms of the alpha2A-and alpha2c adrenoreceptor genes or mutations in norepinephrine transporter (NET) protein influence the physiological (motor and sensory) responses to clonidine...
  32. GENETIC DETERMINATES OF HUMAN COLON NEOPLASIA
    Georgia Wiesner; Fiscal Year: 2003
    ..of affected sibling pairs demonstrates linkage to any of the candidate gene loci APC, COX2, sPLA2, and DNMT, or NAT1/2 for which colon neoplasia susceptibility variants have been identified in murine models or in restricted human ..
  33. Use of Chronoamperometry to Measure Extracellular 5 HT
    Alan Frazer; Fiscal Year: 2005
    ..and mechanisms underlying antidepressant-induced down-regulation of the serotonin transporter (SERT) and norepinephrine transporter (NET). These proteins are the key cellular targets for drugs used in the treatment of depression...
  34. Proteomic /Genetic Approaches to Monoamine Transporters
    Gonzalo Torres; Fiscal Year: 2007
    ..genes encode closely related plasma membrane transporter proteins: the dopamine transporter (DAT), the norepinephrine transporter (NET), and the serotonin transporter (SEPT)...
  35. Crystallization of neurotransmitter transporter homologs
    Da Neng Wang; Fiscal Year: 2007
    ..transporters include the Na+/CI-dependent, serotonin transporter (SERT), dopamine transporter (DAT) and norepinephrine transporter (NET), all members of the neurotransmitter- sodium symporter (NSS) family...
  36. Nanodosing: A path to higher sensitivity and lower toxicity pharmaceuticals
    JAMES KRONAUGE; Fiscal Year: 2009
    ..MIP will produce clinical trial material and conduct human testing of the radioactive drug substance for safety and superiority compared to conventional iobenguane I 123 in normal healthy volunteers. ..
  37. NET - Selective Ligands for the Treatment of Depression
    Kenneth Johnson; Fiscal Year: 2004
    ..Selective ligands for the norepinephrine transporter (NET) such as desipramine are quite effective in some patient populations, but their use is often ..
  38. BRAIN DAT/5-HTT DYSREGULATION IN HUMAN COCAINE USERS
    KARLEY LITTLE; Fiscal Year: 1999
    ..Because the norepinephrine transporter (NET is only subtly different from the DAT, understanding its regulation may shed light on the ..
  39. PHARMACOGENETIC DETERMINANTS OF FETAL SOMATIC MUTATION
    Marjorie Romkes; Fiscal Year: 2002
    ..involved in the metabolism of chemicals found in cigarette smoke, specifically CYP1A1, CYP2E1, GSTM1, GSTT1, NAT1*, and NAT2*...
  40. PHARMACOLOGIC PROBES IN NEURALLY-MEDIATED SYNCOPE
    Italo Biaggioni; Fiscal Year: 2003
    ..to enhancing such responses, using alpha2 receptor antagonism with yohimbine or inhibition of the norepinephrine transporter with desimipramine...
  41. Population Study of Rectal Cancer in Blacks and Whites
    Robert Sandler; Fiscal Year: 2005
    ..The study will focus on the known alleles of the N-acetyltransferase genes (NAT1 and NAT2) and manganese superoxide dismutase (MnSOD) genes using DNA obtained from blood samples...
  42. A Proteomic Analysis of the Norepinephrine Transporter
    Uhna Sung; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The norepinephrine transporter (NET) terminates noradrenergic signals by clearing released NE from extracellular synapses...
  43. COHORT STUDY OF GENETIC MARKERS IN COLON CANCER
    David Hunter; Fiscal Year: 2005
    ..They hypothesize that "fast acetylator" NAT2 genotype, a recently described defect in NAT1, homozygous deletions in the GSTM1 gene, and the "extensive metabolizer" CYP1A1 genotypes are associated with ..
  44. Identification of Novel D1 Selective Agonists
    Ming Liu; Fiscal Year: 2001
    ..receptors, namely, dopamine D2; serotonin 5HT2a; a-adrenergic 2a and 2b; b-adrenergic 1 and 2; and norepinephrine transporter. The choice of multiple receptors rather than the conventional single target approach is intended to ..
  45. QUANTIFICATION OF HEART BETA ADRENERGIC RECEPTORS
    Raymond Muzic; Fiscal Year: 2002
    ..nonspecific uptake, radioactive metabolites in the myocardium, and possibly uptake related to the norepinephrine transporter. Therefore, quantitative assessment of beta-AR specific binding and of beta-AR concentration requires a ..
  46. Real-Time Norepinephrine Transporter Kinetics
    Joel Schwartz; Fiscal Year: 2002
    ..Therapeutic agents for the treatment of depression inhibit norepinephrine transporter (NET) and serotonin transporter (SERT) activities, elevating the concentration of these transmitters in ..
  47. Gene-gene interaction in nasopharyngeal carcinoma
    YIN YAO; Fiscal Year: 2005
    ..function of 5 CYP genes (CYP1A1, CYP1A2, CYP2D6, CYP2E1, CYP1B1) and a few other polymorphisms (GSTM1, GSTT1, NQO1, NAT1 and NAT2) contribute to the development of NPC and to test for the interaction with high risk genotypes and ..
  48. Development of NET-Selective Piperidine-Based PET Ligand
    Anna Liisa Brownell; Fiscal Year: 2006
    ..such as depression, we have a unique opportunity to advance improved PET ligands targeted to the norepinephrine transporter (NET)...
  49. NEUROPEPTIDES AND CARDIOVASCULAR REGULATION
    VIRGINIA BROOKS; Fiscal Year: 2002
    ..activity of sympathetic postganglionic neurons by altering expression of tyrosine hydroxylase and the norepinephrine transporter. 5) If the balance between the sympathoexcitatory and sympathoinhibitory effects of NaCl is disrupted, ..
  50. Piperidine Derivatives as Radiotracers for Serotonin Transporters
    Gilles Tamagnan; Fiscal Year: 2004
    ..of 4-phenyl piperidine will favor binding to 5-HTT relative to dopamine transporter (DAT) and norepinephrine transporter (NET); and 2) elimination of the C6-C7 bridge of the tropane (to yield piperidine analogs) will reduce ..
  51. Synthesis of Selective Dopamine Uptake Inhibitors
    Shaine Cararas; Fiscal Year: 2006
    ..All compounds prepared in this study will be evaluated for dopamine, serotonin and norepinephrine transporter affinity as well as for their ability to inhibit dopamine uptake...
  52. PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISM
    David Hein; Fiscal Year: 2009
    ..likely to initiate breast cancer in those individuals with rapid and/or slow acetylator N-acetyltransferase- 1 (NAT1) and - 2 (NAT2) acetylator genotypes...
  53. The Role of Net1 in the Structure of the Nucleolus
    JAMES LIPFORD; Fiscal Year: 2004
    ..The goals of this project are to characterize the nature of the interaction of Net1 with the nucleolus and to determine the role of Net1 in nucleolar structure...
  54. Molecular Genetics of NAT1 and NAT2 in Prostate Cancer
    Nicholas Lang; Fiscal Year: 2005
    ..regions (a fragment of DNA involved in controlling gene expression) along with the coding and 3'UTR regions of NAT1 and 2 will be examined and all mutations/polymorphisms will be mapped...
  55. Regulation of the Norepinephrine Transporter by Signaling Pathways
    SABRINA DOUGHTY; Fiscal Year: 2009
    ..The high affinity transporter, NET, is the primary mechanism by which noradrenergic synaptic transmission is terminated4'5...
  56. GENE-ENVIRONMENT INTERACTIONS: THE ODYSSEY COHORT
    Sandra Hoffman; Fiscal Year: 2003
    ..and hormones (MTHFR, VDR, CYP17, CYP1B1, COMT, CYP3A4 ); 2) metabolize carcinogens (ADH, GSTM1, GSTT1, GSTP1, NAT1 and NAT2, NOS, CYP1A1, CYP1B1, EH); and 3) control DNA repair processes (XRCC1, XRCC3, XPD)...
  57. HEART IMAGING AGENTS--STRUCTURAL MECHANISTICS STUDY
    David Raffel; Fiscal Year: 2004
    ..All of these agents are avidly taken up into cardiac sympathetic nerves by the neuronal norepinephrine transporter (NET) and subsequently stored in vesicles by the vesicular monoamine transporter (VMAT)...
  58. Cocaine effects on norepinephrine in amygdala
    Carla Rudoy; Fiscal Year: 2007
    ..In addition, it has been previously determined that chronic cocaine self-administration upregulates norepinephrine transporter in the bed nucleus of the stria terminalis (BNST), an area rich in noradrenergic fibers, indicating that ..
  59. HEART IMAGING AGENTS--STRUCTURAL MECHANISTICS STUDY
    David Raffel; Fiscal Year: 2001
    ..All of these agents are avidly taken up into cardiac sympathetic nerves by the neuronal norepinephrine transporter (NET) and subsequently stored in vesicles by the vesicular monoamine transporter (VMAT)...
  60. Radiotracer R and D in Nuclear Medicine and Neuroscience
    Yu Shin Ding; Fiscal Year: 2006
    ..other labeled reboxetine derivatives as the first promising lead compounds for PET imaging of the brain norepinephrine transporter (NET)...
  61. Analysis of an ADHD Whole Genome Association Scan
    Stephen Faraone; Fiscal Year: 2007
    ..All genotype data generated by the GAIN whole genome association scan will be made available to the scientific community by GAIN as soon as the genotypes are completed. [unreadable] [unreadable] [unreadable]..
  62. Searching for ADHD Susceptibility Genes
    Stephen V Faraone; Fiscal Year: 2010
    ..That, in turn, should facilitate the search for newer, more effective treatments for the disorder. ..