nNOS

Summary

Gene Symbol: nNOS
Description: nitric oxide synthase 1
Alias: IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS, nitric oxide synthase, brain, NOS type I, constitutive NOS, neuronal NOS, nitric oxide synthase 1 (neuronal), peptidyl-cysteine S-nitrosylase NOS1
Species: human

Top Publications

  1. ncbi Mechanisms and structural determinants of HIV-1 coat protein, gp41-induced neurotoxicity
    D C Adamson
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 19:64-71. 1999
  2. ncbi The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney
    M Kakoki
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 281:R91-7. 2001
  3. ncbi Interactions between inducible nitric oxide synthase and heme oxygenase-1 in glomerulonephritis
    Prasun K Datta
    Division of Nephrology, Department of Medicine, UMDNJ Robert Wood Johnson Medical School, P O Box 19, MEB 412, New Brunswick, NJ, USA
    Kidney Int 61:847-50. 2002
  4. doi The effect of a promoter polymorphism on the transcription of nitric oxide synthase 1 and its relevance to Parkinson's disease
    Terrie Rife
    James Madison University Biology Department, Harrisonburg, VA 22807, USA
    J Neurosci Res 87:2319-25. 2009
  5. ncbi Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase
    M T Corasaniti
    Faculty of Pharmacy, University of Reggio Calabria, Cantanzaro, Italy
    Neurodegeneration 4:315-21. 1995
  6. doi Genetic association analysis of functional polymorphisms in neuronal nitric oxide synthase 1 gene (NOS1) and mood disorders and fluvoxamine response in major depressive disorder in the Japanese population
    Takenori Okumura
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    Neuropsychobiology 61:57-63. 2010
  7. ncbi 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide
    Tiesong Shang
    Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, 53226, USA
    J Biol Chem 279:19099-112. 2004
  8. pmc Nitric oxide synthase 1 as a potential modifier gene of decline in lung function in patients with cystic fibrosis
    J Texereau
    Service de Physiologie Explorations Fonctionnelles, Hopital Cochin, AP HP, Universite Paris 5, Paris, France
    Thorax 59:156-8. 2004
  9. ncbi Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41
    D C Adamson
    Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Pathology 2 210, Baltimore, MD 21287, USA
    Science 274:1917-21. 1996
  10. ncbi Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytes
    Euan A Ashley
    University Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK
    Circulation 105:3011-6. 2002

Research Grants

  1. Tsung Ung W Woo; Fiscal Year: 2014
  2. Nitric Oxide and gastric motility in female diabetics
    Pandu R Gangula; Fiscal Year: 2010
  3. Thomas S Kilduff; Fiscal Year: 2016
  4. Neurochemical and metabolic regulation in the visual cortex
    MARGARET TT WONG-RILEY; Fiscal Year: 2013
  5. SANTINA AGNES ZANELLI; Fiscal Year: 2014
  6. Pankaj J Pasricha; Fiscal Year: 2016
  7. Cardiovascular Regulation in Hindlimb Unweighted Rats
    Eileen M Hasser; Fiscal Year: 2010
  8. NO-mediated neuroprotection against alcohol toxicity
    Nicholas J Pantazis; Fiscal Year: 2010
  9. Daniel J Bonthius; Fiscal Year: 2016
  10. Calcium Permeable AMPA Receptors: Signaling, Toxicity and Control
    Edward B Ziff; Fiscal Year: 2013

Detail Information

Publications386 found, 100 shown here

  1. ncbi Mechanisms and structural determinants of HIV-1 coat protein, gp41-induced neurotoxicity
    D C Adamson
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 19:64-71. 1999
    ..Using primary mixed cortical cultures from neuronal nitric oxide synthase (NOS) null (nNOS-/-) mice and immunological NOS null (iNOS-/-) mice, we establish iNOS-derived NO as a major mediator of gp41 ..
  2. ncbi The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney
    M Kakoki
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 281:R91-7. 2001
    ..Subsequent infusion of the nonspecific NOS inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME; 50 mg. kg(-1)...
  3. ncbi Interactions between inducible nitric oxide synthase and heme oxygenase-1 in glomerulonephritis
    Prasun K Datta
    Division of Nephrology, Department of Medicine, UMDNJ Robert Wood Johnson Medical School, P O Box 19, MEB 412, New Brunswick, NJ, USA
    Kidney Int 61:847-50. 2002
    ..These observations prompted us to explore regulatory interactions between iNOS and HO-1 in anti-GBM nephritis...
  4. doi The effect of a promoter polymorphism on the transcription of nitric oxide synthase 1 and its relevance to Parkinson's disease
    Terrie Rife
    James Madison University Biology Department, Harrisonburg, VA 22807, USA
    J Neurosci Res 87:2319-25. 2009
    ..These data suggest that if smaller polymorphism size contributes to the higher NOS1 levels in PD patients, an as yet unknown transcriptional mechanism is required...
  5. ncbi Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase
    M T Corasaniti
    Faculty of Pharmacy, University of Reggio Calabria, Cantanzaro, Italy
    Neurodegeneration 4:315-21. 1995
    ..1-10 microM). In conclusion, the present data suggest that death of human CHP100 neuroblastoma cells in culture produced by gp120 involves NO and PGE2 production...
  6. doi Genetic association analysis of functional polymorphisms in neuronal nitric oxide synthase 1 gene (NOS1) and mood disorders and fluvoxamine response in major depressive disorder in the Japanese population
    Takenori Okumura
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
    Neuropsychobiology 61:57-63. 2010
    ..several lines of evidence support an association between abnormalities in neuronal nitric oxide synthases (nNOS) and mood disorders...
  7. ncbi 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide
    Tiesong Shang
    Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, Milwaukee, 53226, USA
    J Biol Chem 279:19099-112. 2004
    ..Depletion of BH(4) decreased the active, dimeric form of neuronal nitric-oxide synthase (nNOS). MPP(+)-mediated "uncoupling" of nNOS decreased *NO and increased superoxide formation...
  8. pmc Nitric oxide synthase 1 as a potential modifier gene of decline in lung function in patients with cystic fibrosis
    J Texereau
    Service de Physiologie Explorations Fonctionnelles, Hopital Cochin, AP HP, Universite Paris 5, Paris, France
    Thorax 59:156-8. 2004
    ....
  9. ncbi Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41
    D C Adamson
    Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Pathology 2 210, Baltimore, MD 21287, USA
    Science 274:1917-21. 1996
    ..Thus, gp41-induced NO formation may contribute to the severe cognitive dysfunction associated with HIV-1 infection...
  10. ncbi Cardiac nitric oxide synthase 1 regulates basal and beta-adrenergic contractility in murine ventricular myocytes
    Euan A Ashley
    University Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK
    Circulation 105:3011-6. 2002
    ..Here, we investigated the role of a type 1 NO synthase isoform (NOS1), which has been recently localized to the cardiac sarcoplasmic reticulum, in the regulation of basal and beta-adrenergic myocardial contraction...
  11. ncbi Transcription of different exons 1 of the human neuronal nitric oxide synthase gene is dynamically regulated in a cell- and stimulus-specific manner
    Jean Paul Boissel
    Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D 55131 Mainz, Germany
    Biol Chem 384:351-62. 2003
    An extensive screening of the human neuronal nitric oxide synthase (nNOS) mRNAs in various human tissues and cell lines unraveled an extreme complexity in the transcription of this gene...
  12. ncbi Nitric oxide synthase 1 is partly compensating for nitric oxide synthase 3 deficiency in nitric oxide synthase 3 knock-out mice and is elevated in murine and human cirrhosis
    Erwin Biecker
    Department of Clinical Pharmacology, University of Berne, Murtenstrasse, Switzerland
    Liver Int 24:345-53. 2004
    The role of endothelial nitric oxide synthase 3 (NOS-3) in the hyperdynamic circulation associated with cirrhosis is established but not that of the neuronal (NOS-1) isoform...
  13. ncbi Transcription of human neuronal nitric oxide synthase mRNAs derived from different first exons is partly controlled by exon 1-specific promoter sequences
    Matthias Bros
    Department of Dermatology, Johannes Gutenberg University, D 55101 Mainz, Germany
    Genomics 87:463-73. 2006
    ..These data demonstrate that expression of the different exon 1-related splice variants of NOS1 mRNA is controlled directly (at least in part) by the associated 5' flanking sequences...
  14. doi Metabolic profile and nitric oxide synthase expression of skeletal muscle fibers are altered in patients with type 1 diabetes
    K Fritzsche
    Institute of Anatomy, University of Leipzig, Germany
    Exp Clin Endocrinol Diabetes 116:606-13. 2008
    ..muscle fiber composition, fiber-specific glycolytic and oxidative enzyme capacity and nitric oxide synthase (NOS) expression in skeletal muscle of patients with type 1 diabetes (T1D) compared to individuals with normal glucose ..
  15. pmc Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme
    D S Bredt
    Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 87:682-5. 1990
    ..The purified enzyme migrates as a single 150-kDa band on SDS/PAGE, and the native enzyme appears to be a monomer...
  16. ncbi Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy
    J E Brenman
    Department of Physiology, University of California, San Francisco School of Medicine 94143 0444, USA
    Cell 82:743-52. 1995
    Nitric oxide (NO) is synthesized in skeletal muscle by neuronal-type NO synthase (nNOS), which is localized to sarcolemma of fast-twitch fibers. Synthesis of NO in active muscle opposes contractile force...
  17. ncbi CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95
    S R Jaffrey
    The Johns Hopkins University School of Medicine, Department of Neuroscience, Pharmacology and Molecular Sciences, Baltimore, Maryland 21205, USA
    Neuron 20:115-24. 1998
    Nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS) is important for N-methyl-D-aspartate (NMDA) receptor-dependent neurotransmitter release, neurotoxicity, and cyclic GMP elevations...
  18. ncbi Binding of dynein light chain (PIN) to neuronal nitric oxide synthase in the absence of inhibition
    I Rodriguez-Crespo
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas, Universidad Complutense, Madrid, 28040, Spain
    Arch Biochem Biophys 359:297-304. 1998
    ..in a rat hippocampal cDNA library using the yeast two-hybrid system and various neuronal nitric oxide synthase (nNOS) fragments as bait, was reported to be an inhibitor of nNOS (Science 274, 774-778, 1996)...
  19. pmc Nitric oxide synthase in cardiac sarcoplasmic reticulum
    K Y Xu
    Department of Medicine, Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 96:657-62. 1999
    ..Immunoelectron microscopy demonstrated labeling of cardiac SR vesicles by using anti-neuronal NOS (nNOS), but not anti-endothelial NOS (eNOS) or anti-inducible NOS (iNOS) antibodies, whereas skeletal muscle SR ..
  20. ncbi Interaction of neuronal nitric-oxide synthase and phosphofructokinase-M
    B L Firestein
    Department of Physiology, UCSF, San Francisco, California 94143 0444, USA
    J Biol Chem 274:10545-50. 1999
    Neurons that express neuronal nitric-oxide synthase (nNOS) are resistant to NO-induced neurotoxicity; however, the mechanism by which these neurons are protected is not clear...
  21. ncbi Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex
    B J Hillier
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Science 284:812-5. 1999
    The PDZ protein interaction domain of neuronal nitric oxide synthase (nNOS) can heterodimerize with the PDZ domains of postsynaptic density protein 95 and syntrophin through interactions that are not mediated by recognition of a typical ..
  22. ncbi PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain
    K S Christopherson
    Department of Physiology, and Program in Biomedical Sciences, University of California, San Francisco, California 94143 0444, USA
    J Biol Chem 274:27467-73. 1999
    ..glutamate receptors, suggesting that there is a specific link between these receptors and neuronal NO synthase (nNOS). Here, we find that PSD-95 assembles a postsynaptic protein complex containing nNOS and NMDA receptors...
  23. ncbi Formation of a native-like beta-hairpin finger structure of a peptide from the extended PDZ domain of neuronal nitric oxide synthase in aqueous solution
    P Wang
    Department of Biochemistry, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, P R China
    Eur J Biochem 267:3116-22. 2000
    Neuronal nitric oxide synthase (nNOS) is targeted to the cell membrane via interactions of its extended PDZ domain with PDZ domains of membrane-associated proteins including PSD-95 and alpha1-syntrophin...
  24. ncbi AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation
    Z P Chen
    St Vincent s Institute of Medical Research, St Vincent s Hospital, Fitzroy, Victoria 3065, Australia
    Am J Physiol Endocrinol Metab 279:E1202-6. 2000
    ....
  25. ncbi Exhaled nitric oxide in patients with asthma: association with NOS1 genotype
    M E Wechsler
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 162:2043-7. 2000
    ....
  26. pmc Single-nucleotide promoter polymorphism alters transcription of neuronal nitric oxide synthase exon 1c in infantile hypertrophic pyloric stenosis
    Dieter Saur
    Department of Internal Medicine II, Technical University of Munich, Ismaningerstrasse 22, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 101:1662-7. 2004
    ..and gastric-outlet obstruction, is associated with altered expression of neuronal nitric oxide synthase (nNOS)...
  27. ncbi NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity
    Fuminori Saitoh
    Department of Neuroplasticity Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Biol Chem 279:29461-8. 2004
    Targeting of neuronal nitric-oxide synthase (nNOS) to appropriate sites in a cell is mediated by interactions with its PDZ domain and plays an important role in specifying the sites of reaction of nitric oxide (NO) in the central nervous ..
  28. ncbi Skeletal muscle nNOS mu protein content is increased by exercise training in humans
    Glenn K McConell
    Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Am J Physiol Regul Integr Comp Physiol 293:R821-8. 2007
    The major isoform of nitric oxide synthase (NOS) in skeletal muscle is the splice variant of neuronal NOS, termed nNOS mu. Exercise training increases nNOS mu protein levels in rat skeletal muscle, but data in humans are conflicting...
  29. pmc IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency
    Dawn L DeMeo
    Brigham and Women s Hospital, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 38:114-20. 2008
    ..Haplotype analysis of IL10 SNPs suggested the strongest association with IL10 promoter SNPs. IL10 is likely an important modifier gene for the development of COPD in individuals with severe AAT deficiency...
  30. pmc Sarcolemma-localized nNOS is required to maintain activity after mild exercise
    Yvonne M Kobayashi
    Howard Hughes Medical Institute, University of Iowa, Roy J and Lucille A Carver College of Medicine, 4283 Carver Biomedical Research Building, 285 Newton Road, Iowa City, Iowa 52242 1101, USA
    Nature 456:511-5. 2008
    ..in specific force production by muscle, and that sarcolemma-localized signalling by neuronal nitric oxide synthase (nNOS) in skeletal muscle is required to maintain activity after mild exercise...
  31. doi Diminished NO generation by injured endothelium and loss of macula densa nNOS may contribute to sustained acute kidney injury after ischemia-reperfusion
    Osun Kwon
    Dept of Medicine, Div of Nephrology, Penn State Milton S Hershey Medical Ctr, Penn State College of Medicine, 500 University Dr, Hershey, PA 17033 0850, USA
    Am J Physiol Renal Physiol 296:F25-33. 2009
    ..No differences were observed in the inducible NOS staining pattern between the two groups. Neuronal NOS staining was rarely observed in the macula densae of subjects but was prominent in control tissues...
  32. pmc Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children
    M T Salam
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Allergy 66:412-9. 2011
    ..The aims of the study were to evaluate the role of genetic variations in nitric oxide synthases and arginases on FeNO in children and to assess the influence of asthma and respiratory allergy on these genetic associations...
  33. doi Neuronal nitric oxide synthase regulates endothelial inflammation
    Subhadeep Chakrabarti
    Departments of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada
    J Leukoc Biol 91:947-56. 2012
    ..However, recent data suggest an important role for nNOS in the endothelium, although little is known about factors regulating this novel eNOS...
  34. ncbi Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains
    J E Brenman
    Department of Physiology, School of Medicine, University of California at San Fancisco, California 94143, USA
    Cell 84:757-67. 1996
    Neuronal nitric oxide synthase (nNOS) is concentrated at synaptic junctions in brain and motor endplates in skeletal muscle...
  35. ncbi Interaction of neuronal nitric-oxide synthase with caveolin-3 in skeletal muscle. Identification of a novel caveolin scaffolding/inhibitory domain
    V J Venema
    Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912
    J Biol Chem 272:28187-90. 1997
    Neuronal nitric-oxide synthase (nNOS) has been shown previously to interact with alpha1-syntrophin in the dystrophin complex of skeletal muscle...
  36. ncbi NOS1 polymorphism is associated with atopy but not exhaled nitric oxide levels in healthy children
    May Ali
    Department of Paediatrics, University of Western Australia, Perth, Australia
    Pediatr Allergy Immunol 14:261-5. 2003
    ..3% vs. 13.6%, respectively, p = 0.03). This suggests that variations in the NOS1 gene may contribute to atopy without this relationship being reflected by FENO...
  37. ncbi Nitric oxide synthase polymorphisms and asthma phenotypes in Chinese children
    T F Leung
    Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
    Clin Exp Allergy 35:1288-94. 2005
    ..Single nucleotide polymorphisms (SNPs) in nitric oxide synthase (NOS) genes have been associated with atopy and exhaled NO concentrations in Caucasians...
  38. doi Neuronal nitric oxide synthase regulates basal microvascular tone in humans in vivo
    Michael D Seddon
    Department of Cardiology, King s College London School of Medicine, 125 Coldharbour Ln, London SE5 9NU, United Kingdom
    Circulation 117:1991-6. 2008
    ..These effects have been attributed to NO production by the endothelial NO synthase (eNOS); however, recent evidence suggests that a neuronal NO synthase (nNOS) may also be expressed in arterial vessels.
  39. ncbi Differential expression of nitric oxide synthases (NOS 1-3) in human skeletal muscle following exercise countermeasure during 12 weeks of bed rest
    Jana Rudnick
    Department of Anatomy, Campus Benjamin Franklin, Charite University Medicine Berlin, Germany
    FASEB J 18:1228-30. 2004
    ..linked to muscle activity, we investigated altered expression of the three major isoforms of nitric oxide synthase (NOS 1-3) at cellular compartments during prolonged HDT BR without (control group) and with resistance exercise ..
  40. pmc Neuronal nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo
    Dean L Kellogg
    Division of Geriatrics and Gerontology, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    J Physiol 586:847-57. 2008
    ..We hypothesized that neuronal NOS (nNOS, NOS I) effects cutaneous vasodilatation during whole-body heat stress, but not during local skin warming...
  41. doi Effects of neuronal nitric oxide synthase on human coronary artery diameter and blood flow in vivo
    Michael Seddon
    King s College London British Heart Foundation Centre, Cardiovascular Division, Department of Cardiology, London, UK
    Circulation 119:2656-62. 2009
    ..reported that human forearm basal microvascular tone in vivo is tonically regulated by neuronal NO synthase (nNOS), in contrast to an acetylcholine-stimulated reduction in tone, which is eNOS dependent...
  42. pmc Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor alpha, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain
    P Koka
    Department of Neurology, University of California, School of Medicine, Los Angeles 90024, USA
    J Exp Med 182:941-51. 1995
    ....
  43. ncbi Human immunodeficiency virus-1-infected macrophages induce inducible nitric oxide synthase and nitric oxide (NO) production in astrocytes: astrocytic NO as a possible mediator of neural damage in acquired immunodeficiency syndrome
    K Hori
    Division of Cytokine Biology and the Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA
    Blood 93:1843-50. 1999
    ..It also leads us to speculate that neurologic damage observed in HIV disease may ensue from prolonged, high level production of NO...
  44. ncbi Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor. Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation
    R Golser
    Institut fur Pharmakologie und Toxikologie, Karl Franzens Universitat Graz, Universitatsplatz 2, A 8010 Graz, Austria
    J Biol Chem 275:5291-6. 2000
    ..310-329) we studied the interaction of the receptor with purified eNOS and neuronal nitric-oxide synthase (type I) (nNOS). The peptide inhibited formation of L-citrulline by eNOS and nNOS with IC(50) values of 10.6 +/- 0.4 microM and 7...
  45. pmc Inhibition of rat colon contractility by prostacyclin (IP-) receptor agonists: involvement of NANC neurotransmission
    Y M Qian
    Department of Pharmacology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT
    Br J Pharmacol 115:163-71. 1995
    ..3. A transmitter role for nitric oxide was investigated. The nitric oxide synthase (NOS) inhibitor N omega-nitro-L-arginine methyl ester (L-NAME, 100 microM) inhibited the actions of both cicaprost (10 ..
  46. pmc Comparison of effects of chronic and acute administration of NG-nitro-L-arginine methyl ester to the rat on inhibition of nitric oxide-mediated responses
    C E Bryant
    William Harvey Research Institute, Medical College of Saint Bartholomew s Hospital, London
    Br J Pharmacol 114:1673-9. 1995
    ..The resistance of peripheral neuronal NO responses to chronic treatment with L-NAME indicates that selective inhibition of different isoforms of NOS may be achieved in vivo.
  47. pmc The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity
    B Zingarelli
    Division of Critical Care Medicine, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Br J Pharmacol 120:357-66. 1997
    ..both the inducible isoforms of nitric oxide synthase (iNOS) and cyclo-oxygenase (COX-2) are induced, inhibition of NOS also results in inhibition of arachidonic acid metabolism...
  48. pmc Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids
    T A Swierkosz
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 114:1335-42. 1995
    ..b>NOS activity was assessed by measuring the accumulation of nitrite using the Griess reaction...
  49. ncbi Two distinct populations of neurons expressing nitric oxide synthase mRNA in the female rat preoptic area: site specific changes induced by sex steroids
    T Ishihara
    Department of Obstetrics and Gynecology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
    J Nippon Med Sch 68:328-34. 2001
    ..in the basal forebrain of gonadectomized juvenile female rats visualized neuronal nitric oxide synthase (nNOS) mRNA in two distinct cellular populations, one in the organum vasculosum of the lamina terminals (OVLT) and the ..
  50. pmc Involvement of tyrosine kinase in the induction of cyclo-oxygenase and nitric oxide synthase by endotoxin in cultured cells
    P Akarasereenont
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 113:1522-8. 1994
    1. Cyclo-oxygenase (COX) and nitric oxide synthase (NOS) are two enzymes which have distinct cytokine-inducible isoforms (COX-2 and iNOS). Many cytokine receptors have an intracellular tyrosine kinase domain...
  51. ncbi Inducible nitric oxide synthase in vascular smooth muscle cells from prehypertensive spontaneously hypertensive rats
    A Singh
    MRC Multidisciplinary Research Group on Hypertension, , , , Canada
    Am J Hypertens 9:867-77. 1996
    ..Inhibitors of NOS, NG-monomethyl-L-arginine (L-NMMA) and N omega-nitro-L-arginine methyl ester (L-NAME), did not block the induction ..
  52. pmc Glibenclamide-induced inhibition of the expression of inducible nitric oxide synthase in cultured macrophages and in the anaesthetized rat
    C C Wu
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 114:1273-81. 1995
    ..In contrast, the degree of inhibition of nitrite formation caused by the nitric oxide synthase (NOS) inhibitor N omega-nitro-L-arginine methyl ester (L-NAME) was similar when this agent was given up to 10 h after ..
  53. pmc Involvement of nitric oxide in the endothelium-dependent relaxation induced by hydrogen peroxide in the rabbit aorta
    A Zembowicz
    Department of Pharmacology, Copernicus Academy of Medicine, , Poland
    Br J Pharmacol 110:151-8. 1993
    ..methyl ester (L-NAME, 30 microM) or NG-monomethyl-L-arginine (300 microM), inhibitors of nitric oxide synthase (NOS), in a manner that was reversible by L-, but not by D-arginine (2mM)...
  54. pmc Regulation of prostaglandin production by nitric oxide; an in vivo analysis
    D Salvemini
    G D Searle, Department of Molecular Pharmacology, St Louis, MO 63167, USA
    Br J Pharmacol 114:1171-8. 1995
    ..2. The induced enzymes were inhibited in vivo with selective COX and NOS inhibitors...
  55. pmc Group B Streptococcus and E. coli LPS-induced NO-dependent hyporesponsiveness to noradrenaline in isolated intrapulmonary arteries of neonatal piglets
    E Villamor
    Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 115:261-6. 1995
    ..NOS activity determined by the conversion of radiolabelled L-arginine to citrulline, but did not modify the constitutive NOS activity. This NOS induction was abolished by coincubation with dexamethasone (3 X 10-6 M).6...
  56. pmc Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy
    A Tomlinson
    Department of Experimental Pathology, William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 113:693-8. 1994
    1. The profiles of cyclo-oxygenase (COX) and nitric oxide synthase (NOS) isoforms were determined in the rat carrageenin-induced pleurisy model of acute inflammation. 2...
  57. ncbi Reduction of myocardial infarct size by inhibition of inducible nitric oxide synthase
    D Wang
    Department of Medicine, and Heart and Vascular Institute, Henry Ford Hospital, Detroit, Michigan 48202-2689, USA
    Am J Hypertens 12:174-82. 1999
    ..whether iNOS activity contributed to myocardial damage (eg, infarct size), we administered the first dose of the NOS inhibitors 24 h before LAD occlusion and then a second dose after surgery...
  58. pmc An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus
    A Gibson
    Smooth Muscle Pharmacology Group, King s College London
    Br J Pharmacol 107:715-21. 1992
    ..The relaxations were unaffected by the nitric oxide synthase (NOS) inhibitor, L-NG-nitro-arginine (10 microM) (L-NOARG). 3...
  59. pmc Inhibition of nitric oxide synthesis in vascular smooth muscle by retinoids
    K Hirokawa
    Department of Clinical Pharmacology, Royal Postgraduate Medical School, London
    Br J Pharmacol 113:1448-54. 1994
    1. These studies examine the effect of retinoids on interleukin 1 beta (IL-1 beta)-induced nitric oxide synthase (NOS) activity in cultured rat aortic vascular smooth muscle (VSM) cells and isolated rat aortic rings. 2...
  60. ncbi Endothelin and blood pressure regulation in the female rat: studies in normal pregnancy and with nitric oxide synthase inhibition-induced hypertension
    L G Thaete
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Northwestern University Medical School, Evanston Northwestern Healthcare, IL 60201, USA
    Hypertens Pregnancy 19:233-47. 2000
    ..ET) in blood pressure regulation in normal pregnant and nonpregnant rats and with nitric oxide synthase (NOS) inhibition...
  61. pmc Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock
    C Szabo
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 108:786-92. 1993
    ..enhanced formation of nitric oxide (NO) and the relative importance of the constitutive and inducible NO synthase (NOS) for the development of immediate (within 60 min) and delayed (at 180 min) vascular hyporeactivity to noradrenaline ..
  62. pmc Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects
    P K Moore
    Biomedical Sciences Division, King s College, University of London
    Br J Pharmacol 110:219-24. 1993
    ..induced antinociception in the mouse was correlated with inhibition of brain (cerebellum) nitric oxide synthase (NOS) activity. Maximum antinociceptive activity and NOS inhibition was detected 18-30 min following i.p. administration...
  63. ncbi Vasoactive hormones induce nitric oxide synthase mRNA expression and nitric oxide production in human endothelial cells and monocytes
    M Schena
    Department of Medicine and Experimental Oncology, University of Turin, Italy
    Am J Hypertens 12:388-97. 1999
    Isoform-2 nitric oxide synthase (NOS-2) mRNA expression and nitric oxide (NO) production are induced in endothelial cells and monocytes by cytokines such as gammaIFN and LPS...
  64. pmc Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles
    R C Babbedge
    Biomedical Sciences Division, King s College, University of London
    Br J Pharmacol 110:225-8. 1993
    1. 7-Nitro indazole (7-NI) produces potent inhibition of rat cerebellar nitric oxide synthase (NOS) with an IC50 of 0.9 +/- 0.1 microM (n = 6). NOS activity is dependent on the presence of both exogenous CaCl2 and NADPH...
  65. pmc Relaxin-induced increased coronary flow through stimulation of nitric oxide production
    T Bani Sacchi
    Department of Human Anatomy and Histology, University of Florence, Italy
    Br J Pharmacol 116:1589-94. 1995
    ..nitrite in the perfusates induced by RLX was significantly reduced by pretreatment with the nitric oxide synthase (NOS) inhibitor, NG-monomethyl-L-arginine (L-NMMA, 10(-4) M). 4...
  66. pmc Neuronal nitric oxide synthase expression is induced in neocortical astrocytes after spreading depression
    A O Caggiano
    Department of Neurology, University of Chicago, IL 60637, USA
    J Cereb Blood Flow Metab 18:75-87. 1998
    ..Immunohistochemical, computer-based image analyses and Western blotting show that the number of neuronal NOS (nNOS)-positive cells in the somatosensory cortex was significantly increased at 6 hours and 3 days after SD (P ..
  67. pmc Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock
    C Thiemermann
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 110:177-82. 1993
    1. This study investigates the role of tumour necrosis factor (TNF) in the induction of nitric oxide synthase (NOS) by bacterial endotoxin (lipopolysaccharide; LPS) in a rat model of endotoxin shock. 2...
  68. ncbi Effect of salt loading on nitric oxide synthase expression in normotensive rats
    Z Ni
    Department of Medicine, University of California, Irvine, USA
    Am J Hypertens 14:155-63. 2001
    ..of 48-h or 3-week duration was studied on immunodetectable endothelial (eNOS), inducible (iNOS), and neuronal (nNOS) NOS expressions of relevant organs in male Sprague-Dawley rats...
  69. ncbi Effect of imidapril on myocardial remodeling in L-NAME-induced hypertensive rats is associated with gene expression of NOS and ACE mRNA
    N Kobayashi
    Department of Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Am J Hypertens 13:199-207. 2000
    ..inhibitors on these myocardial remodelings are associated with local gene expression of nitric oxide synthase (NOS) and ACE mRNA in the LV...
  70. ncbi [Reduced neuronal nitric oxide synthetase and c-protein kinase levels in Alzheimer's disease]
    L Gargiulo
    , , ,
    Rev Neurol 30:301-3. 2000
    ..RESULTS: Lower levels of neuronal constitutive NOS (37% +/- 2.5 and 52% +/- 3...
  71. ncbi Effect of reduction of nitric oxide on plasma and kidney tissue angiotensin II levels
    G E Garcia
    Division of Nephrology-Hypertension, Veterans Affairs Medical Center and University of California, San Diego School of Medicine, La Jolla 92161, USA
    Am J Hypertens 10:1103-8. 1997
    Nitric oxide synthase (NOS) blockade increases blood pressure (BP) and modifies glomerular and tubular function. Angiotensin II (AII) blockade restores glomerular and tubular function but does not lower BP...
  72. ncbi Benidipine stimulates nitric oxide synthase and improves coronary circulation in hypertensive rats
    N Kobayashi
    Department of Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Am J Hypertens 12:483-91. 1999
    ..only by lessening the endothelial damage by the reduction of blood pressure levels, but also by the stimulation of NOS activity and eNOS mRNA, and this increased NOS activity and eNOS mRNA expression may play a role in the ..
  73. ncbi The influence of nitric oxide on tumour vascular tone
    G M Tozer
    Tumour Microcirculation Group, CRC Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, England
    Acta Oncol 34:373-7. 1995
    ..Phenylephrine itself induced an oscillatory change in tumour perfusion pressure. The nitric oxide synthase (NOS) inhibitor N omega-nitro-L-arginine (L-NNA) caused a dose-dependent increase in vascular resistance in ex vivo ..
  74. pmc Effect of 7-nitro indazole on neurotransmission in the rat vas deferens: mechanisms unrelated to inhibition of nitric oxide synthase
    H S Allawi
    Pharmacology Group, King s College University of London
    Br J Pharmacol 113:282-8. 1994
    1. The effect of the nitric oxide synthase (NOS) inhibitor, 7-nitro indazole (7-NI), on sympathetic and purinergic neurotransmission in the rat isolated vas deferens preparation has been studied. 2...
  75. pmc Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity
    G J Southan
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 114:510-6. 1995
    ..3. Ethyl-TU and isopropyl-TU are 4-6 times more potent than MeArg in inhibiting the constitutive NOS activity in homogenates of bovine aortic endothelial cells (eNOS) and are more potent pressor agents than ..
  76. pmc Effect of nitric oxide synthase inhibition on long-term potentiation at associational-commissural and mossy fibre synapses on CA3 pyramidal neurones
    P J Nicolarakis
    Department of Physiology, University of Sydney, Australia
    Br J Pharmacol 111:521-4. 1994
    1. The sensitivity of long-term potentiation (LTP) to nitric oxide synthase (NOS) inhibition was determined for two synaptic input systems onto CA3 pyramidal neurones the LTP of which display differential sensitivity to N-methyl-D-..
  77. ncbi Nitric oxide synthetase inhibition hinders facilitation of active avoidance learning by nicotine in rats
    O Yilmaz
    Ege University Center for Brain Research and School of Medicine, Department of Physiology, Izmir, Turkey
    Behav Pharmacol 11:505-10. 2000
    ..therefore tested active avoidance performance in rats given L-Nomega-nitroarginine (L-NA) to inhibit NO synthetase (NOS) prior to nicotine administration. Male Sprague-Dawley rats received L-NA (30 or 50 mg/kg), nicotine (0...
  78. ncbi The water extract of Jagamchotang protects the ischemia/reperfusion-induced cytotoxicity of rat neonatal myocardial cells via generation of nitric oxide
    J Oh
    Department of Anatomy, Wonkwang University School of Medicine, Iksan, Chonbuk, South Korea
    Immunopharmacol Immunotoxicol 22:297-315. 2000
    ..NG-monomethyi-L-argine (NGMMA), a specific inhibitor of nitric oxide synthase (NOS), significantly blocks the protective effects of Jagamchotang on the cells after ischemia/reperfusion...
  79. ncbi Nitric oxide synthase activity in renal cortex and medulla of normotensive and spontaneously hypertensive rats
    E Nava
    , Facultad de Medicina, Universidad de Murcia, Spain
    Am J Hypertens 9:1236-9. 1996
    ..We have measured the activity of NO synthase (NOS) in the renal medulla, renal cortex, heart, and aorta from normotensive Wistar Kyoto rats (WKY) and spontaneously ..
  80. ncbi Erythrocytes may synthesize their own nitric oxide
    B C Jubelin
    Department of Surgery, Tulane University Medical Center, New Orleans, Louisiana 70112, USA
    Am J Hypertens 9:1214-9. 1996
    ..The myenteric neurons are also positive for neuronal NOS (NOS1), calmodulin, and neuropeptide Y, indicating that they are NO-producing neurons...
  81. ncbi [Hemodynamic effects of sub-chronic NO synthase inhibition in conscious dogs: role of EDRF/NO in muscular exertion]
    L Puybasset
    , ,
    Arch Mal Coeur Vaiss 88:1217-21. 1995
    Acute and chronic administration of nitric oxide (NO) synthase (NOS) inhibitors increase mean arterial blood pressure (MAP) in rats but their hemodynamic effects in other species remain unknown...
  82. ncbi Lack of involvement of neuronal nitric oxide synthase in the pathogenesis of a transgenic mouse model of familial amyotrophic lateral sclerosis
    F Facchinetti
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Neuroscience 90:1483-92. 1999
    ..Together, these results do not support a significant role for neuronal-derived nitric oxide in the pathogenesis of familial amyotrophic lateral sclerosis transgenic mice...
  83. pmc Contribution of K+ channels and ouabain-sensitive mechanisms to the endothelium-dependent relaxations of horse penile small arteries
    D Prieto
    Departamento de Fisiologia, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 123:1609-20. 1998
    ..relaxations were abolished by mechanical endothelial cell removal, attenuated by the nitric oxide (NO) synthase (NOS) inhibitor, NG-nitro-L-arginine (L-NOARG, 100 microM) and unchanged by indomethacin (3 microM)...
  84. pmc Release by ultraviolet B (u.v.B) radiation of nitric oxide (NO) from human keratinocytes: a potential role for nitric oxide in erythema production
    G Deliconstantinos
    Department of Physiology, University of Athens Medical School, Greece
    Br J Pharmacol 114:1257-65. 1995
    ..In this study we attempted to determine whether human keratinocytes possess a nitric oxide (NO) synthase (NOS), if this enzyme could be activated to release NO following exposure to ultraviolet B (u.v...
  85. ncbi Chronic estrogen treatment in female transgenic (mRen2)27 hypertensive rats augments endothelium-derived nitric oxide release
    P Li
    The Hypertension Center, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina 27157-1032, USA
    Am J Hypertens 10:662-70. 1997
    ..E2 treatment augmented the contraction response to NOS inhibition in both Tg(+) and Tg(-) rats, resulting in a response in Tg(+) rats that was no different from Tg(-) ..
  86. ncbi Nitrergic proprioceptive afferents originating from quadriceps femoris muscle are related to monosynaptic Ia-motoneuron stretch reflex circuit in the dog
    Jozef Marsala
    Institute of Neurobiology, Slovak Academy of Sciences, Kosice, Slovak Republic
    Cell Mol Neurobiol 26:1387-412. 2006
    ....
  87. ncbi Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets
    Om P Mishra
    Department of Pediatrics, Drexel University College of Medicine and St Christopher s Hospital for Children, Philadelphia, PA 19129, USA
    Neurosci Lett 401:81-5. 2006
    ..activity in the cerebral cortex of newborn piglets is mediated by NO derived from neuronal nitric oxide synthase (nNOS)...
  88. ncbi Neuronal nitric oxide synthase activity in the paraventricular nucleus buffers central endothelin-1- induced pressor response and vasopressin secretion
    Noreen F Rossi
    Department of Medicine, Wayne State University School of Medicine and John D Dingell VA Medical Center, Detroit, Michigan 48201, USA
    J Cardiovasc Pharmacol 44:S283-8. 2004
    ..The present studies were designed to test the hypothesis that decreasing neuronal nitric oxide synthase (nNOS) activity within the PVN will potentiate ET-1-induced increases in arterial pressure and alter plasma AVP secretion...
  89. ncbi Nitric oxide-mediated mechanism of neuronal nitric oxide synthase and inducible nitric oxide synthase expression during hypoxia in the cerebral cortex of newborn piglets
    O P Mishra
    Department of Pediatrics, Drexel University College of Medicine, and St Christopher s Hospital for Children, Philadelphia, PA 19129, USA
    Neuroscience 140:857-63. 2006
    ..that during hypoxia nitric oxide-mediated up-regulation of nitric oxide synthases will continue the perpetual cycle of nitric oxide generation-->NOS up-regulation-->nitric oxide generation resulting in hypoxic neuronal death.
  90. pmc Inhibition of neuronal nitric oxide synthase in ovine model of acute lung injury
    Perenlei Enkhbaatar
    Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 37:208-14. 2009
    ..In this study, we have tested the hypothesis that inhibition of neuronal nitric oxide synthase could ameliorate the severity of acute lung injury using our well-established ovine model of cutaneous burn and smoke inhalation...
  91. ncbi Cyclooxygenase-2 mediates increased renal renin content induced by low-sodium diet
    P Harding
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Mich 48202, USA
    Hypertension 29:297-302. 1997
    ..regulating renal renin content by using mice in which the neuronal nitric oxide synthase gene has been disrupted (nNOS-/-) compared with its two progenitor strains, the 129/SvEv and the C57BL/6, to determine if the absence of neuronal ..
  92. ncbi [Role of endothelial nitric oxide synthases in the contractile response to angiotensin II of the aorta in rats. Wistar Kyoto and hypertensive rats]
    A Zerrouk
    Institut Henri Beaufour Research Labs, Les Ulis
    Arch Mal Coeur Vaiss 87:1001-4. 1994
    ..NO is produced through the conversion of L-arginine to L-citruline by NO synthases (NOS) which exist at least in two isoforms...
  93. ncbi Ultrastructural localization of neuronal nitric oxide synthase in the laterodorsal tegmental nucleus of wild-type and knockout mice
    F Rothe
    Institute of Medical Neurobiology, University of Magdeburg, Germany
    Neuroscience 94:193-201. 1999
    ..The splice isoform a is located predominantly at the membranes of the endoplasmic reticulum...
  94. pmc Dexamethasone worsens nitric oxide inhibition-induced hypertension and renal dysfunction
    C Qiu
    Department of Physiology, Robert C. Byrd Health Sciences Center of West Virginia University, Morgantown 26506-9229, USA
    Am J Hypertens 13:1097-102. 2000
    ..that in the conscious chronically L-NAME-treated (approximately =10 mg/kg/24 h) hypertensive rats, acute systemic NOS inhibition elicited a further increase in blood pressure (BP), indicating partial restoration of NO production...
  95. ncbi alpha-Tocopherol increased nitric oxide synthase activity in blood vessels of spontaneously hypertensive rats
    M A Newaz
    Faculty of Medicine, International Islamic University, Malaysia, Kuantan
    Am J Hypertens 12:839-44. 1999
    ..protection provided by different doses of alpha-tocopherol was compared by determining nitric oxide synthase (NOS) activity in blood vessels of spontaneously hypertensive rats (SHR) treated with alpha-tocopherol...
  96. pmc Vascular and perivascular nitric oxide release and transport: biochemical pathways of neuronal nitric oxide synthase (NOS1) and endothelial nitric oxide synthase (NOS3)
    Kejing Chen
    Department of Biomedical Engineering, 613 Traylor Building, 720 Rutland Avenue, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Free Radic Biol Med 42:811-22. 2007
    ..pathways of enzymatic NO synthesis and the availability of NOS isozymes to quantify the NO production by neuronal NOS (NOS1) and endothelial NOS (NOS3)...
  97. pmc Up-regulation of the peroxiredoxin-6 related metabolism of reactive oxygen species in skeletal muscle of mice lacking neuronal nitric oxide synthase
    Luis Da Silva-Azevedo
    Department of Physiology, Charite Campus Benjamin Franklin, Arnimallee 22, Berlin Dahlem, Germany
    J Physiol 587:655-68. 2009
    Although neuronal nitric oxide synthase (nNOS) plays a substantial role in skeletal muscle physiology, nNOS-knockout mice manifest an only mild phenotypic malfunction in this tissue...
  98. ncbi Nitric oxide in the control of renal hemodynamics and excretory function
    D S Majid
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Am J Hypertens 14:74S-82S. 2001
    ..We also demonstrated that a constant rate infusion of a NO donor in dogs pretreated with a NOS inhibitor resulted in increases in sodium excretion but failed to restore the slope of the relation between ..
  99. ncbi Central depressor action of nitric oxide is deficient in genetic hypertension
    C L Cabrera
    University of Michigan, Ann Arbor 48109-0622, USA
    Am J Hypertens 9:237-41. 1996
    Inhibition of NO synthase (NOS) in the central nervous system (CNS) causes a pressor response. This observation indicates that NO is normally produced at CNS site(s) where it has a tonic blood pressure lowering effect...
  100. doi Coupling between neuronal nitric oxide synthase and glutamate receptor 6-mediated c-Jun N-terminal kinase signaling pathway via S-nitrosylation contributes to ischemia neuronal death
    H M Yu
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou 221002, Jiangsu, People s Republic of China
    Neuroscience 155:1120-32. 2008
    ..by the demonstration that, in cerebral neurons, NO mainly generates from neuronal nitric oxide synthase (nNOS) during the early stages of reperfusion...
  101. doi Relative contribution of eNOS and nNOS to endothelium-dependent vasodilation in the mouse aorta
    Luciano S A Capettini
    Department of Physiology and Biophysics, ICB, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Eur J Pharmacol 643:260-6. 2010
    ..However, we have recently shown that neuronal nitric oxide synthase (nNOS)-derived H(2)O(2) is also an endothelium-dependent relaxing factor in the mouse aorta...

Research Grants71

  1. Tsung Ung W Woo; Fiscal Year: 2014
    ..stress, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) and neuronal nitric oxide synthase (nNOS), and the catalytic and modulatory subunits of the antioxidant enzyme glutamate cysteine ligase in homogenized PFC...
  2. Nitric Oxide and gastric motility in female diabetics
    Pandu R Gangula; Fiscal Year: 2010
    ..Recent studies have implicated a role for dysregulation of neuronal nitric oxide synthase (nNOS) in myenteric neurons and we surmised that gender differences in nitrergic control of gastric motility may possibly ..
  3. Thomas S Kilduff; Fiscal Year: 2016
    ..period, we identified a population of cells in the cerebral cortex that express the neuronal nitric oxide synthase (nNos) within which the transcription factor Fos is expressed specifically during recovery sleep (RS) after sleep ..
  4. Neurochemical and metabolic regulation in the visual cortex
    MARGARET TT WONG-RILEY; Fiscal Year: 2013
    ..They will also provide the basis for future gene therapy for visual deficits resulting from faulty energy metabolism. ..
  5. SANTINA AGNES ZANELLI; Fiscal Year: 2014
    ..In preliminary experiments, we found that pharmacologic inhibition of neuronal nitric oxide synthase (nNOS) prevents hypoxia-reoxygenation seizures in immature rodents...
  6. Pankaj J Pasricha; Fiscal Year: 2016
    ..of transplanting CNS-derived NSC (CNS-NSC) in mice with a genetic deletion of the neuronal nitric oxide synthase (nNOS) enzyme, we have shown that CNS-NSC can successfully engraft and differentiate into nNOS expressing neurons, can ..
  7. Cardiovascular Regulation in Hindlimb Unweighted Rats
    Eileen M Hasser; Fiscal Year: 2010
    ..SPECIFIC AIM 2: Examine central mechanisms within the paraventricular nucleus (PVN) of the hypothalamus that are altered by cardiovascular deconditioning. ..
  8. NO-mediated neuroprotection against alcohol toxicity
    Nicholas J Pantazis; Fiscal Year: 2010
    ..Our experiments will utilize a mouse strain carrying a null mutation for neuronal nitric oxide synthase (nNOS-/-), thus these animals lack NO-mediated neuroprotection...
  9. Daniel J Bonthius; Fiscal Year: 2016
    ..Over-expression of the gene encoding neuronal nitric oxide synthase (nNOS), which produces NO within neurons, protects neurons against alcohol-induced death...
  10. Calcium Permeable AMPA Receptors: Signaling, Toxicity and Control
    Edward B Ziff; Fiscal Year: 2013
    ..We have shown that Ca2+-permeable AMPARs, like the NMDAR, can activate neuronal nitric oxide synthase (nNOS)...
  11. Novel candidate mechanisms of fragile X syndrome
    KENNETH YU CHUNG KWAN; Fiscal Year: 2012
    ..I propose to study the molecular underpinnings of fragile X syndrome. This work will have implications for potential therapies for fragile X syndrome, as well as autism spectrum disorder. ..
  12. KENNETH YU CHUNG KWAN; Fiscal Year: 2015
    ..The proposed studies have implications for current approaches to study of FXS and have the potential to uncover novel molecular pathways of not only FXS but also ASD. ..
  13. Role of cortical interneurons in synchronization of brain electroencephalogram
    Dmitry Gerashchenko; Fiscal Year: 2013
    ..in our laboratory found that changes in SWA parallel the changes in the activity of neuronal nitric oxide synthase (nNOS)-immunoreactive cells in the cortex in three mammalian species...
  14. nNOS-containing striatal interneurons and methamphetamine-induced neurotoxicity
    ASHLEY NICOLE FRICKS-GLEASON; Fiscal Year: 2013
    ..suggests that the generation of NO arises as a consequence of the activation of neuronal nitric oxide synthase (nNOS) located post-synaptic to the DA nerve terminal, in a subpopulation of striatal interneurons...
  15. Mechanisms and Regulation of Inducible Nitric Oxide Synthase
    JOSEPH EDWARD SABAT; Fiscal Year: 2010
    ..There are several known physiological functions of NO generated by iNOS and its two constitutive isofrms (nNOS and eNOS) including regulation of vascular tone, neurotransmission, cell signaling, and combating infection...
  16. Structural/Functional Modularity in Nitric Oxide Synthase
    Linda J Roman; Fiscal Year: 2012
    ..For example, sequence inserts in the constitutive NOS enzymes (nNOS and eNOS) confer regulatory properties that do not exist in the inducible isoform (iNOS)...
  17. James Patrick Gonzalez; Fiscal Year: 2015
    ..this project, modulation of the nitric oxide (NO) pathway, specifically related to neuronal nitric oxide synthase (nNOS), will be examined in DMD carrier models to understand both the cell type requirement of functional pathway members ..
  18. Thomas L Pallone; Fiscal Year: 2014
    ..which CaV subclasses are suppressed by NO and which NOS isoforms generate NO in the DVR wall of rats and eNOS / nNOS null mice. The relevant signaling pathways involved will be delineated...
  19. Richard B Silverman; Fiscal Year: 2016
    ..The successes we have had in the design of selective neuronal nitric oxide synthase (nNOS) inhibitors during the last funding period will be the springboard for future design and synthesis efforts, using ..
  20. NITRIC OXIDE SYNTHASE: ENZYMOLOGY AND METABOLIC ROLE
    Owen Griffith; Fiscal Year: 2004
    ..Three NOS isoforms have been identified, including endothelial (eNOS; or type III), neuronal (nNOS; or, type I) and inducible (iNOS; or, type II) NOS...
  21. Aqueous humor dynamics studies in vivo and in vitro
    PAUL LEON KAUFMAN; Fiscal Year: 2010
    ..To simulate the dramatically reduced levels of nitric oxide synthase (NOS) in the anterior segment in glaucoma, a short-term equivalent of nitrergic denervation will be created in monkeys ..
  22. Oxygen/Nitrogen Stress in Acetaminophen Hepatotoxicity
    Jack A Hinson; Fiscal Year: 2013
    ..The ultimate goal is to develop new approaches to treat acetaminophen poisoning in humans. ..
  23. Dual AAV Vectors for Duchenne Muscular Dystrophy Therapy
    Dongsheng Duan; Fiscal Year: 2012
    ..that the 6 kb minigene can fully restore muscle force, this minigene cannot restore neuronal nitric oxide synthase (nNOS) to the sarcolemma. The loss of sarcolemmal nNOS leads to functional ischemia in mdx mice and DMD patients...
  24. John A Auchampach; Fiscal Year: 2016
    ..NOS isoforms (eNOS, nNOS or iNOS) and their signaling pathways activated by the EETs will be identified...
  25. Kathryn Hinchee-Rodriguez; Fiscal Year: 2016
    ..In skeletal muscle, NO is produced by neuronal nitric oxide synthase (nNOS), the tissue's primary NOS isoform...
  26. Todd D Gould; Fiscal Year: 2014
    ..This application proposes experiments in the context of endophenotype strategies that will reveal molecular mechanisms whereby lithium acts to exert its therapeutics effects. ..
  27. Perioperative Stroke and Cerebral Conditioning in the Female
    Stephanie J Murphy; Fiscal Year: 2010
    ..In Aim 4, we hypothesize that IsoPC suppresses neuronal nitric oxide synthase (nNOS) activity and consequent peroxynitrite (ONOO) formation, and that the sexually dimorphic response to nNOS-derived ..
  28. Radical Intermediates of Nitric Oxide Synthase &Myocardial Ischemia Reperfusion
    Ah Lim Tsai; Fiscal Year: 2013
    ..Our recent studies disclosed very different radical intermediate profile and regulation mechanism in eNOS and nNOS catalysis...
  29. Golgi-associated NO-cGMP Signaling Defect in Muscular Dystrophy
    Gail D Thomas; Fiscal Year: 2013
    ..The demonstration that transgenic expression of nNOS in mdx mouse muscle ameliorates the dystrophic phenotype has focused attention on this signaling protein...
  30. Xin Yu; Fiscal Year: 2014
    ..Recent studies have indicated the role of neuronal NOS (nNOS) in regulating EC coupling, with several aspects of nNOS modulation of myocardial contractility and its ..
  31. Signaling Mechanisms of the Dystrophin-Glycoprotein Complex
    Andrea Arnett; Fiscal Year: 2012
    ..Some of these proteins, including syntrophin and neuronal nitric oxide synthase (nNOS), have documented signaling properties and may play important signaling roles in muscle tissue...
  32. Direct effect of cholesterol on glucose-stimulated insulin secretion
    Mingming Hao; Fiscal Year: 2010
    ..I also show that the function of two proteins critically involved in GSIS, neuronal nitric oxide synthase (nNOS) and glucokinase (GK), depends on cholesterol-enriched membrane microdomains on the insulin granules...
  33. Inhibition of NO Dependent Splanchnic Hyperemia Improves CFS/POTS
    ANTHONY JAMES OCON; Fiscal Year: 2012
    ..We hypothesize that CFS/POTS is caused by either increased neuronal NOS activity (nNOS, NOS-1) or increased inducible NOS (INOS, NOS-2), that there is evidence for increased NOS ..
  34. Nitric Oxide Synthase Isoforms in the Kidney
    Jennifer S Pollock; Fiscal Year: 2010
    ..It was previously shown that the inner medullary collecting duct has the highest nitric oxide synthase (NOS) activity in the rat kidney. All three NOS isoforms are expressed in the collecting duct...
  35. Regulation of Syntrophin Function
    Stanley C Froehner; Fiscal Year: 2013
    ..Syntrophin-associated signaling proteins include ion and water channels, neuronal nitric oxide synthase (nNOS), protein and lipid kinases, transporters and G-protein coupled receptors...
  36. Hypothermia for Cardiac Arrest: Optimizing Akt-Nitric Oxide Synthase Signaling
    DAVID GUSTAV BEISER; Fiscal Year: 2012
    ..Test whether hypothermia protection can be reproduced by NOS substrate/cofactor repletion strategies...
  37. DeWayne Townsend; Fiscal Year: 2014
    ..2) To determine the mechanistic link between neuronal nitric oxide synthase (nNOS) and dystrophin in the auto-regulatory control of blood flow in the heart...
  38. Role of neuronal nitric oxide in neuroplasticity-associated gene expression
    EDUARDO FRANCISCO GALLO; Fiscal Year: 2010
    ..Production of nitric oxide (NO) by the neuronal isoform of nitric oxide synthase (nNOS) has emerged as a key player in NMDAR signaling...
  39. NOS1/NOS3 Functional Effects on Cardiac Myocyte Function
    Mark T Ziolo; Fiscal Year: 2010
    ..provided by applicant): Cardiac myocytes constitutively express enzymes termed neuronal nitric oxide synthase (nNOS, NOS1) and endothelial nitric oxide synthase (eNOS, NOS3)...
  40. Small molecular weight eNOS inhibitors for the treatment of pancreatic cancer
    CHRISTOPHER COUNTER; Fiscal Year: 2012
    ..To this end, we discovered eNOS, one of three proteins in the Nitric Oxide Synthase family (composed of eNOS, nNOS and iNOS) that generate nitric oxide (NO), mediates oncogenic KRAS tumorigenesis...
  41. Zvonimir S Katusic; Fiscal Year: 2016
    ..studies will be followed by in vivo testing of the proposed hypothesis in genetically modified mice including eNOS, nNOS-, and iNOS-deficient mice, [unreadable]1 or [unreadable]1 isoform of soluble guanylate cyclase-deficient mice, and ..
  42. REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANE
    Christopher S Wilcox; Fiscal Year: 2012
    ..Specific Aim II will investigate the hypothesis that neuronal nitric oxide synthase (nNOS)- derived NO generated during macula densa (MD) solute reabsorption activates COX-2 dependent signaling pathway ..
  43. Age Differences of Brain Circuits Mediating Morphine Effect &Morphine Tolerance
    Dusica Bajic; Fiscal Year: 2011
    ..In the second aim, the involvement of the neuronal isoform of nitric oxide synthase (nNOS) in tolerance will be investigated...
  44. ANDREA GRACE HOHMANN; Fiscal Year: 2014
    ..IC87201 disrupts the functional protein-protein interaction involving PDZ domains (neuronal nitric oxide synthase, nNOS and postsynaptic density protein 95, PSD95) required for NMDA receptor signaling...
  45. THOMAS LEWIS POULOS; Fiscal Year: 2016
    ..Mammals have 3 NOS isoforms: eNOS (endothelial NOS, regulates blood pressure), nNOS (neuronal NOS, neural signaling), and iNOS (inducible NOS, immune system)...
  46. Changjian Feng; Fiscal Year: 2016
    ..Three NOS isoforms, iNOS, eNOS and nNOS (inducible, endothelial, and neuronal NOS), achieve their key biological functions by tight regulation of interdomain electron transfer (IET) process via ..
  47. MICROVASCULAR PERMEABILITY OF THE CEREBRAL CIRCULATION
    WILLIAM MAYHAN; Fiscal Year: 2000
    ..Adapted from Investigator's Abstract): The central hypothesis of this project is that nitric oxide synthase (eNOS, nNOS and iNOS) and cyclooxygenase (COX-2) play a critical role in regulating basal and agonist-induced increases in ..
  48. Neuronal nitric oxide synthase in early critical fetal brain injury from hypoxia
    Sidhartha Tan; Fiscal Year: 2010
    ..Our previous research has identified new novel designer drugs aimed at neuronal nitric oxide synthase (nNOS) that prevent motor deficits in our animal model in pilot studies...
  49. Role of cGKII in AMPA Receptor Transport
    Edward B Ziff; Fiscal Year: 2013
    ..cGKII is under the control of the NMDA receptor through NMDAR activation of nNOS, leading to the production of nitric oxide, activation of soluble guanylate cyclase and production of cGMP, which ..
  50. MOLECULAR MECHANISMS OF ESTROGENS VASCULAR ACTIONS
    Kenneth Clark; Fiscal Year: 2003
    ..However, it is not currently clear how this occurs or if, in addition to eNOS, neuronal nitric oxide synthase (nNOS) or inducible nitric oxide synthase (iNOS) are also important in maintaining the sustained vasodilatory response ..
  51. NEURONAL NITRIC OXIDE SYNTHASE IN NEUROPATHIC PAIN
    Zhigang Luo; Fiscal Year: 2001
    ..data indicate a correlation between increased mRNA levels in sensory neurons of neuronal nitric oxide synthase (nNOS), an enzyme that catalyzes the production of nitric oxide (NO), and the development of neuropathic pain (allodynia) ..
  52. Paco S Herson; Fiscal Year: 2016
    ..is of most direct importance, that (iii) the novel nitrosylation mechanisms contributes to ischemic damage by prolonging T286 phosphorylation, and that (iv) NR2B-binding enables efficient nitrosylation via localizing CaMKII near nNOS.
  53. Frank Porreca; Fiscal Year: 2014
    ..stimuli known to promote migraine attack in humans or after a CSD event? (Aim 2);and third, what are the roles of nNOS and CGRP in promoting enhanced sensitivity to migraine triggers, and/or CSD events and excitation of dural ..
  54. Tetrahydrobiopterin and pain
    Clifford J Woolf; Fiscal Year: 2012
    ..b>nNOS is upregulated in association with the increase in BH4 and we will test if BH4 produces pain by producing an ..
  55. The Roles of nNOS, Ontogeny, and Gender in Cocaine Sensitization
    Mara A Balda; Fiscal Year: 2010
    ..Specifically, we found that nNOS KO mice are less sensitive to the psychomotor, rewarding, and neurotoxic effects of psycho stimulants...
  56. Jonathan H Fox; Fiscal Year: 2015
    ..We have also demonstrated elevated iron in an inducible mutant huntingtin expressing cell line and shown that nNOS inhibition reverses this...
  57. Hyperbaric Oxygen: A Novel Approach to Treatment of Chronic Pain
    RAYMOND MARK QUOCK; Fiscal Year: 2013
    ..of the antiallodynic response to single and repeated HBO2 treatments;and 2) characterize HBO2-induced changes in nNOS expression and determine the anatomical relationship between brainstem nNOS expression, GABA and descending ..
  58. Genes and Hormonal Fetal Antecedents to Sex Differencs in the Brain in Depression
    Jill M Goldstein; Fiscal Year: 2011
    ..with HPA circuitry development and MOD (cortiocotropin releasing hormone (CRH), BDNF, GABA, GLU, neuronal NO (nNOS), estrogen receptors (ER)a and p, and arginine vasopressin (AVP))...
  59. Anti-CD47 mAb Therapy to Improve Kidney Transplantation
    PAMELA ANN TOY-MANNING; Fiscal Year: 2011
    ..Current work indicates that enhancing the beneficial, low levels of nitric oxide (NO) produced by eNOS and nNOS can dramatically improve IRI and transplant outcomes...
  60. Effects of Advanced EA on Hypertension: Role of nNOS-NO in the Dorsal Medulla
    Sheng Xing Ma; Fiscal Year: 2010
    ..Expression of neuronal nitric oxide (NO) synthase (nNOS) is predominantly reduced in the gracile nucleus and NTS regions in DS rats, and decreased nNOS expression in the ..
  61. CHRISTINE BAYLIS; Fiscal Year: 2015
    ..to reduction in renal L-Arg synthesis and also reductions in endothelial arginine transport;alterations in the neuronal NOS (nNOS) isoforms in the kidney cortex which predispose to CKD progression...
  62. Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for Cerebr
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012
    ..treatments on the brain microcirculation will be assessed by intravital microscopy and the expression of eNOS, nNOS, iNOS and HO-1will be determined...
  63. Isoform specific effects of the autoinhibitory element and the C-terminus of nitr
    JOHN SALERNO; Fiscal Year: 2009
    ..Primary control of eNOS and nNOS is exerted through regulation of electron flux from NADPH to the oxygenase active site...
  64. Cardiovascular Response to Glutamate Nitric Oxide
    WILLIAM TALMAN; Fiscal Year: 2006
    ..in the nucleus tractus solitarii (NTS) of rats and have identified strong associations between glutamate and nNOS and between each of the receptor types and nNOS in NTS...
  65. Polymorphisms of Neural NOS and the Asthma Phenotype
    Michael Wechsler; Fiscal Year: 2005
    ..as the nitric oxide synthases, and allelic variations of NOS1, the gene for neural nitric oxide synthase (type I NOS) on chromosome l2q, have been identified and associated with asthma...