NLRC4

Summary

Gene Symbol: NLRC4
Description: NLR family CARD domain containing 4
Alias: AIFEC, CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, FCAS4, IPAF, NLR family CARD domain-containing protein 4, CARD, LRR, and NACHT-containing protein, ICE-protease activating factor, NOD-like receptor C4, caspase recruitment domain family, member 12, caspase recruitment domain-containing protein 12, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
Species: human

Top Publications

  1. ncbi Nucleotide binding to CARD12 and its role in CARD12-mediated caspase-1 activation
    Chafen Lu
    Millennium Pharmaceuticals, Inc, 35 Landsdowne Street, Cambridge, MA 02139, USA
    Biochem Biophys Res Commun 331:1114-9. 2005
  2. ncbi Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1
    Jean Marie Bruey
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Cell 129:45-56. 2007
  3. doi Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection
    Alessandra Pontillo
    Laboratory of Medical Investigation in Dermatology and Immunodeficiency, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Acquir Immune Defic Syndr 59:121-5. 2012
  4. ncbi Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia
    Wei neng Fu
    Department of Haematology Oncology, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    Oncogene 22:451-5. 2003
  5. ncbi Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1
    J L Poyet
    Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 276:28309-13. 2001
  6. ncbi NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    Laetitia Agostini
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Immunity 20:319-25. 2004
  7. ncbi Multiple roles of CLAN (caspase-associated recruitment domain, leucine-rich repeat, and NAIP CIIA HET-E, and TP1-containing protein) in the mammalian innate immune response
    Jason S Damiano
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Immunol 173:6338-45. 2004
  8. ncbi Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis
    Subhashini Sadasivam
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India
    Oncogene 24:627-36. 2005
  9. doi Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death
    Yatender Kumar
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research CSIR, Uppal Road, Hyderabad 500007, India
    Biochem J 427:91-104. 2010
  10. doi The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
    Yue Zhao
    Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    Nature 477:596-600. 2011

Research Grants

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
  2. Gabriel Nunez; Fiscal Year: 2015
  3. Molecular mechanisms of pathogen recognition by the Nod-like receptor NLRC4
    Fayyaz S Sutterwala; Fiscal Year: 2012
  4. Gabriel Nunez; Fiscal Year: 2016
  5. Samithamby Jeyaseelan; Fiscal Year: 2016
  6. Shawn J Skerrett; Fiscal Year: 2016
  7. Sanjay Batra; Fiscal Year: 2016
  8. Role of caspases in Legionella pneumophila pulmonary infection
    Amal O Amer; Fiscal Year: 2013
  9. Igor E Brodsky; Fiscal Year: 2014
  10. How can caspases control intracellular pulmonary pathogens
    Amal O Amer; Fiscal Year: 2010

Detail Information

Publications201 found, 100 shown here

  1. ncbi Nucleotide binding to CARD12 and its role in CARD12-mediated caspase-1 activation
    Chafen Lu
    Millennium Pharmaceuticals, Inc, 35 Landsdowne Street, Cambridge, MA 02139, USA
    Biochem Biophys Res Commun 331:1114-9. 2005
    b>CARD12 (Ipaf/Clan) is an important regulator of caspase-1 activation. It belongs to the family of the nucleotide-binding site and leucine-rich repeat (NBS-LRR) proteins...
  2. ncbi Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1
    Jean Marie Bruey
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Cell 129:45-56. 2007
    ..The findings reveal an interaction of host defense and apoptosis machinery...
  3. doi Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection
    Alessandra Pontillo
    Laboratory of Medical Investigation in Dermatology and Immunodeficiency, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    J Acquir Immune Defic Syndr 59:121-5. 2012
    ..Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects and 158 healthy controls...
  4. ncbi Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia
    Wei neng Fu
    Department of Haematology Oncology, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    Oncogene 22:451-5. 2003
    ..This study suggests that Apaf-1 DNA promoter methylation might contribute to the inactivation of Apaf-1 expression. However, Apaf-1 protein levels might also be controlled at post-transcription level...
  5. ncbi Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1
    J L Poyet
    Center for Apoptosis Research and the Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 276:28309-13. 2001
    ..Here we describe the identification of a human Apaf-1-related protein, named Ipaf that contains an NH2-terminal CARD domain, a central nucleotide-binding domain, and a COOH-terminal regulatory ..
  6. ncbi NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    Laetitia Agostini
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Immunity 20:319-25. 2004
    ..Macrophages from Muckle-Wells patients spontaneously secrete active IL-1beta. Increased inflammasome activity is therefore likely to be the molecular basis of the symptoms associated with NALP3-dependent autoinflammatory disorders...
  7. ncbi Multiple roles of CLAN (caspase-associated recruitment domain, leucine-rich repeat, and NAIP CIIA HET-E, and TP1-containing protein) in the mammalian innate immune response
    Jason S Damiano
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Immunol 173:6338-45. 2004
    ..Caspase-associated recruitment domain, leucine-rich repeat, and NACHT-containing protein (CLAN), also known as ICE protease-activating factor, belongs to a branch of the NACHT family that contains proteins ..
  8. ncbi Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis
    Subhashini Sadasivam
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India
    Oncogene 24:627-36. 2005
    ..Here we show that Ipaf, a human CED-4 homologue and an activator of caspase-1, is induced by p53...
  9. doi Interaction with Sug1 enables Ipaf ubiquitination leading to caspase 8 activation and cell death
    Yatender Kumar
    Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research CSIR, Uppal Road, Hyderabad 500007, India
    Biochem J 427:91-104. 2010
    ..on interacting proteins, and Ipaf [ICE (interleukin-1beta-converting enzyme)-protease activating factor] {NLRC4 [NLR (Nod-like receptor) family CARD (caspase activation and recruitment domain)-containing 4]} an inflammasome ..
  10. doi The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
    Yue Zhao
    Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
    Nature 477:596-600. 2011
    ..The inflammasome assembled by the NOD-like receptor (NLR) protein NLRC4 responds to bacterial flagellin and a conserved type III secretion system (TTSS) rod component...
  11. pmc Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin
    Els F Halff
    Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands
    J Biol Chem 287:38460-72. 2012
    The NOD-like receptors NAIP5 and NLRC4 play an essential role in the innate immune response to the bacterial tail protein flagellin...
  12. ncbi Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis
    Subhash Thalappilly
    Centre for Cellular and Molecular Biology, Hyderabad, India
    FEBS J 273:2766-78. 2006
    ..We analyzed the role of ICE protease-activating factor (Ipaf), an activator of caspase 1 in p53-dependent apoptosis...
  13. ncbi A recombinant, chimeric enzyme with a novel mechanism of action leading to greater potency and selectivity than tissue-type plasminogen activator
    J H Robinson
    Department of Biotechnology, SmithKline Beecham Pharmaceuticals, Surrey, England, UK
    Circulation 86:548-52. 1992
    ..active center acylation with a novel inverse acylating agent, 4'-amidinophenyl-4-chloroanthranilic acid (AP-CLAN). An acylated (CLAN-) hybrid was cleared from the bloodstream of guinea pigs at 0.35 +/- 0.02 ml/min...
  14. ncbi Arsenic-related skin lesions and glutathione S-transferase P1 A1578G (Ile105Val) polymorphism in two ethnic clans exposed to indoor combustion of high arsenic coal in one village
    Guo Fang Lin
    Laboratory of Toxicology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Pharmacogenet Genomics 16:863-71. 2006
    ..This study aimed to investigate the cluster of arsenism cases and the possible relevant factors including GSTP1 polymorphism in two clans of different ethnic origin living in one village for generations...
  15. ncbi Purification and characterization of phytocystatins from kiwifruit cortex and seeds
    Maysoon Rassam
    Gene Technologies, The Horticultural and Food Research Institute of New Zealand, PB 92169, Auckland, New Zealand
    Phytochemistry 65:19-30. 2004
    ..chinensis. The predominant cortex cystatin, KCPI1, inhibited clan CA, family C1 (papain family) cysteine proteinases (papain, chymopapain, bromelain, ficin, human cathepsins B, H ..
  16. ncbi Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease
    D P Dickinson
    Medical College of Georgia, School of Dentistry, Department of Oral Biology, and Maxillofacial Pathology, Augusta 30912, USA
    Crit Rev Oral Biol Med 13:238-75. 2002
    ..In mammals, two of the major clans represented in the genome are: the CA clan, whose members share a structure and evolutionary history with papain; and the CD clan, which includes the ..
  17. pmc Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model
    Samuel G Melendez-Lopez
    Department of Pathology, University of California, San Diego, San Diego, California 92103 8416, USA
    Eukaryot Cell 6:1130-6. 2007
    ..Arginine was strongly preferred at P2, an unusual specificity among clan CA proteinases. A new vinyl sulfone inhibitor, WRR483, was synthesized based on this specificity to target EhCP1...
  18. doi Kininogens: More than cysteine protease inhibitors and kinin precursors
    Gilles Lalmanach
    INSERM U618, Protéases et Vectorisation Pulmonaires, IFR 135 Imagerie Fonctionnelle, Universite Francois Rabelais, Tours, France
    Biochimie 92:1568-79. 2010
    ..Kininogens are multifunctional glycosylated molecules related to cystatins (clan IH, family I25)...
  19. ncbi Social evolution in the Hallstatt--La Tène period
    Vaclav Smrcka
    Charles University in Prague, First Faculty of Medicine, Institute for History of Medicine and Foreign Languages, Prague, Czech Republic
    Acta Univ Carol Med Monogr 156:27-56. 2009
    ..Not only are the ruler and his "court" put in the graves, but also all the members of the clan. We suppose that the new social group of priests, who gained a high social prestige both in wartime and in ..
  20. pmc Genome-wide structural and evolutionary analysis of the P450 monooxygenase genes (P450ome) in the white rot fungus Phanerochaete chrysosporium: evidence for gene duplications and extensive gene clustering
    Harshavardhan Doddapaneni
    Environmental Genetics and Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0056, USA
    BMC Genomics 6:92. 2005
    ..In order to understand the functional diversity and the evolutionary mechanisms and significance of these hemeproteins, here we report a genome-wide structural and evolutionary analysis of the P450ome of this fungus...
  21. pmc Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection
    Anwari Akhter
    Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, OH, USA
    PLoS Pathog 5:e1000361. 2009
    ..Most inbred mouse strains are restrictive to L. pneumophila infection except for the A/J, Nlrc4(-/-) (Ipaf(-/-)), and caspase-1(-/-) derived macrophages. Particularly, caspase-1 activation is detected during L...
  22. ncbi Identification of Asp-130 as the catalytic nucleophile in the main alpha-galactosidase from Phanerochaete chrysosporium, a family 27 glycosyl hydrolase
    D O Hart
    Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada
    Biochemistry 39:9826-36. 2000
    ..J. 316, 695-696]. This family, together with the family 36 alpha-galactosidases, forms glycosyl hydrolase clan GH-D, a superfamily of alpha-galactosidases, alpha-N-acetylgalactosaminidases, and isomaltodextranases which are ..
  23. pmc Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4
    Anne Fortier
    Department of Biochemistry, McGill University, McIntyre Medical Building, 3655 Promenade Sir William Osler, Room 907, Montreal, Quebec, Canada H3G 1Y6
    Infect Immun 77:4794-805. 2009
    ..pneumophila. Moreover, macrophages doubly heterozygous (Naip5AJ/WT Irf8R294C/WT or Nlrc4-/+ Irf8R294C/WT) for combined loss-of-function mutations in Irf8 and in either Naip5 or Nlrc4 are highly ..
  24. pmc Mutagenic definition of a papain-like catalytic triad, sufficiency of the N-terminal domain for single-site core catalytic enzyme acylation, and C-terminal domain for augmentative metal activation of a eukaryotic phytochelatin synthase
    Nataliya D Romanyuk
    Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Plant Physiol 141:858-69. 2006
    ..that the N-terminal half of AtPCS1 and its equivalents from other sources have the hallmarks of a papain-like, Clan CA Cys protease...
  25. pmc Regulation of cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells by convergence of distinct beta1 and beta3 integrin pathways
    Mark S Filla
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    Invest Ophthalmol Vis Sci 50:5723-31. 2009
    To determine the beta1/beta3 integrin-mediated pathways that regulate cross-linked actin network (CLAN) formation in human trabecular meshwork (HTM) cells...
  26. pmc IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus
    Daniel Sojka
    Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic and Faculty of Biological Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic
    Int J Parasitol 37:713-24. 2007
    ..from the hard tick Ixodes ricinus (termed IrAE), which we believe is the first such characterisation of a clan CD family C13 cysteine peptidase (protease) in arthropods...
  27. pmc Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila
    Christopher L Case
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Infect Immun 77:1981-91. 2009
    ..pathway involving the host nucleotide-binding domain and leucine-rich repeat-containing protein Ipaf (NLRC4)...
  28. ncbi Crystal structure of aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli and conformational change of methionine 260 involved in substrate recognition
    Kiyoshi Ito
    Graduate School of Biomedical Sciences, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    J Biol Chem 281:33664-76. 2006
    Aminopeptidase N from Escherichia coli is a broad specificity zinc exopeptidase belonging to aminopeptidase clan MA, family M1. The structures of the ligand-free form and the enzyme-bestatin complex were determined at 1.5- and 1...
  29. doi Matrix metalloproteinases: fold and function of their catalytic domains
    Cynthia Tallant
    Proteolysis Lab, Molecular Biology Institute of Barcelona, CSIC, Barcelona Science Park, Helix Building, c Baldiri Reixac, 15 21, E 08028 Barcelona, Spain
    Biochim Biophys Acta 1803:20-8. 2010
    ..The catalytic domains of 13 MMPs have been structurally analyzed so far and they belong to the "metzincin" clan of metalloendopeptidases...
  30. ncbi Potential applications of smart clothing solutions in health care and personal protection
    Harriet Meinander
    Tampere University of Technology, SmartWearLab, Sinitaival 6, FIN 33720 Tampere, Finland
    Stud Health Technol Inform 108:278-85. 2004
    ..Clothing Area Network--Clan" is a research project aiming to develop a technical concept and technology needed in enabling both wired and ..
  31. pmc cDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components
    A Colige
    Laboratory of Connective Tissues Biology, University of Liege, Belgium
    Proc Natl Acad Sci U S A 94:2374-9. 1997
    ..The protein contained zinc-binding sequences of the clan MB of metallopeptidases that includes procollagen C-proteinase/BMP-1...
  32. ncbi Structural and functional characterization of binding sites in metallocarboxypeptidases based on Optimal Docking Area analysis
    Daniel Fernandez
    Institut de Biotecnologia i Biomedicina, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
    Proteins 68:131-44. 2007
    The metallocarboxypeptidases (MCPs) belonging to the clan MC were studied by the Optimal Docking Area (ODA) method to evaluate protein-protein binding sites and to provide a basis for the identification of binding partners for this class ..
  33. ncbi The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation
    Mohamed Lamkanfi
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    J Immunol 178:8022-7. 2007
    Similar to Ipaf and caspase-1, the Nod-like receptor protein Naip5 restricts intracellular proliferation of Legionella pneumophila, the causative agent of a severe form of pneumonia known as Legionnaires' disease...
  34. ncbi A role for Nod-like receptors in autophagy induced by Shigella infection
    Toshihiko Suzuki
    Division of Bacterial Pathogenesis, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    Autophagy 4:73-5. 2008
    ..we presented evidence that caspase-1 activation and IL-1beta processing induced by Shigella are mediated through Ipaf, a cytosolic pattern-recognition receptor of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR)..
  35. ncbi [The active site of human glucocerebrosidase: structural predictions and experimental validations]
    Sylvie Fabrega
    INSERM U458, Hopital Robert Debre, 48, bd Serurier, 75019 Paris
    J Soc Biol 196:151-60. 2002
    ..Glucocerebrosidase belongs to the clan GH-A of glycoside hydrolases, a large group of enzymes which function with retention of the anomeric configuration ..
  36. ncbi A study on the social structure and dispersal patterns of hamadryas baboons living in a commensal group at Taif, Saudi Arabia
    Akio Mori
    Primate Research Institute, Kyoto University, Kanrin, Inuyama, Aichi, 484 8506, Japan
    Primates 48:179-89. 2007
    ..one male unit (OMU), the band, and the troop--have been observed at all sites studied, but a fourth--the clan--has been observed at only one site, Erer-Gota, Ethiopia, during a longitudinal check of the dispersion of ..
  37. pmc On the origins of arrestin and rhodopsin
    Carlos E Alvarez
    Center for Molecular and Human Genetics, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    BMC Evol Biol 8:222. 2008
    ..We conducted phylogenetic studies to reconstruct the history of arrestins. Those findings, in turn, led us to investigate the origin of the photosensory GPCR rhodopsin...
  38. ncbi Post-translational modifications of the basic peroxidase isoenzyme from Zinnia elegans
    Carlos Gabaldón
    Department of Plant Biology, University of Murcia, 30100, Murcia, Spain
    Plant Mol Biol 65:43-61. 2007
    ..suggested that the processing of the N-terminal pro-peptide of ZePrxs is performed by a peptidase from the SB clan (S8 family, subfamily A) of serine-type proteases...
  39. pmc Ov-APR-1, an aspartic protease from the carcinogenic liver fluke, Opisthorchis viverrini: functional expression, immunolocalization and subsite specificity
    Sutas Suttiprapa
    Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
    Int J Biochem Cell Biol 41:1148-56. 2009
    ..viverrini. Phylogenetic analysis indicated that Ov-APR-1 is cathepsin D-like, conforming with Clan AA, Family A1 of the MEROPS classification...
  40. ncbi Intervention and prevention of hereditary hemolytic disorders in India: a case study of two ethnic communities of Sundargarh district in Orissa
    R S Balgir
    Division of Human Genetics, Regional Medical Research Center, Indian Council of Medical Research, Opposite Kalinga Hospital, Chandrasekharpur, Bhubaneswar 751 023, Orissa
    J Assoc Physicians India 56:851-8. 2008
    ..For sustainability, imparting of relevant training to local paramedical staff, and to undertake periodic follow up for evaluation, intervention and clinical management through local PHCs/hospitals...
  41. ncbi Crystal structure of a dodecameric tetrahedral-shaped aminopeptidase
    Santina Russo
    Departement fur Chemie und Biochemie, University of Berne, Freiestrasse 3, CH 3012 Bern, Switzerland
    J Biol Chem 279:51275-81. 2004
    ..The monomer has a typical clan MH fold, as found for example in Aeromonas proteolytica aminopeptidase, containing a dinuclear zinc active center...
  42. ncbi Human tissue kallikreins: physiologic roles and applications in cancer
    Carla A Borgono
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5 Canada
    Mol Cancer Res 2:257-80. 2004
    Tissue kallikreins are members of the S1 family (clan SA) of trypsin-like serine proteases and are present in at least six mammalian orders...
  43. ncbi Cysteine proteases of malaria parasites
    Philip J Rosenthal
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, Box 0811, San Francisco, CA 94143, USA
    Int J Parasitol 34:1489-99. 2004
    ..The best characterised Plasmodium cysteine proteases are the falcipains, a family of papain-family (clan CA) enzymes...
  44. ncbi Comparative molecular analysis of two asparaginyl endopeptidases and encoding genes from Fasciola gigantica
    Poom Adisakwattana
    Faculty of Allied Health Sciences, Thammasat University, Pathumthani, Thailand
    Mol Biochem Parasitol 156:102-16. 2007
    In this study we describe the first cysteine proteinases of the MEROPS Clan CD family C13 in Fasciola gigantica...
  45. pmc Leishmania subtilisin is a maturase for the trypanothione reductase system and contributes to disease pathology
    Ryan K Swenerton
    Department of Pathology, Sandler Center for Drug Discovery, University of California, San Francisco, California 94158, USA
    J Biol Chem 285:31120-9. 2010
    ..The subtilisin protease (SUB; Clan SB, family S8) of Leishmania donovani was cloned and found to possess a unique catalytic triad...
  46. pmc Characteristics of traditional birth attendants and their beliefs and practices in the Offot Clan, Nigeria
    S M Itina
    St Luke s Hospital, Anua, Akwa Ibom State, Nigeria
    Bull World Health Organ 75:563-7. 1997
    This article presents the findings of a survey of a group of 52 traditional birth attendants (TBAs) in a clan in south-eastern Nigeria...
  47. pmc Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family
    Vasilis Vasiliou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Hum Genomics 2:329-35. 2006
    The NAD(P)H:quinone acceptor oxidoreductase (NQO) gene family belongs to the flavoprotein clan and, in the human genome, consists of two genes (NQO1 and NQO2)...
  48. ncbi Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
    Luigi Franchi
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Immunol 7:576-82. 2006
    ..b>Ipaf, a cytosolic pattern-recognition receptor in the family of nucleotide-binding oligomerization domain-leucine-rich ..
  49. ncbi The crystal structure of human cytosolic beta-glucosidase unravels the substrate aglycone specificity of a family 1 glycoside hydrolase
    Sandra Tribolo
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    J Mol Biol 370:964-75. 2007
    ..As for all the clan of GH-A enzymes, the two catalytic glutamate residues are located on strand 4 (the acid/base Glu165) and on strand ..
  50. doi Autosomal recessive hyponatremia due to isolated salt wasting in sweat associated with a mutation in the active site of Carbonic Anhydrase 12
    Emad Muhammad
    Department of Virology and Developmental Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, 84105, Israel
    Hum Genet 129:397-405. 2011
    ..Three affected individuals from a small Bedouin clan presented with failure to thrive, hyponatremic dehydration and hyperkalemia with isolated sweat salt wasting...
  51. pmc X-ray structure of human acid-beta-glucosidase, the defective enzyme in Gaucher disease
    Hay Dvir
    1 Departments of Structural Biology and Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
    EMBO Rep 4:704-9. 2003
    ..catalytic domain consists of a (beta/alpha)(8) TIM barrel, as expected for a member of the glucosidase hydrolase A clan. The distance between the catalytic residues E235 and E340 is consistent with a catalytic mechanism of retention...
  52. ncbi Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase
    Sherwin Wilk
    Department of Pharmacology, Box 1215, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Arch Biochem Biophys 407:176-83. 2002
    ..DAP is a member of the M18 family of the MH clan of cocatalytic metallopeptidases. The human and mouse enzymes have been cloned...
  53. doi Interplay between acid phosphatase and cysteine proteases in mediating vitellin degradation during early embryogenesis of Periplaneta americana
    Danielle M P Oliveira
    Laboratorio de Entomologia Medica, Programa de Parasitologia e Biologia Celular, Instituto de Biofisica Carlos Chagas Filho, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Cidade Universitaria, Rio de Janeiro, RJ, Brazil
    J Insect Physiol 54:883-91. 2008
    ..In parallel, two classes of proteases were detected and located within yolk granules: a clan CA-cysteine protease, which was inhibited by E-64, insensitive to CA 074 and activated by acidic pH at day 3; and a ..
  54. pmc On the relevance of the Met-turn methionine in metzincins
    Cynthia Tallant
    Proteolysis Laboratory, Department of Structural Biology, Molecular Biology Institute of Barcelona, Consejo Superior de Investigaciones Cientificas, Barcelona Science Park, Helix Building, c Baldiri Reixac, 15 21, E 08028 Barcelona, Spain
    J Biol Chem 285:13951-7. 2010
    The metzincins are a clan of metallopeptidases consisting of families that share a series of structural elements...
  55. ncbi The gene repertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptors
    Thóra K Bjarnadóttir
    Department of Neuroscience, Uppsala University, BMC, Box 593, 751 24, Uppsala, Sweden
    Gene 362:70-84. 2005
    Glutamate receptors (also known as clan C) are one of the main groups of GPCRs with many subgroup linked through complex evolutionary relationships...
  56. ncbi One-male units and clans in a colony of hamadryas baboons (Papio hamadryas hamadryas): effect of male number and clan cohesion on feeding success
    Fernando Colmenares
    Departamento de Psicobiologia, Facultad de Psicologia, Universidad Complutense de Madrid, Campus de Somosaguas, Madrid, Spain
    Am J Primatol 68:21-37. 2006
    ..This paper examines the effect of male number and rivalry between males within a clan on their ability to compete for access to a clumped food resource...
  57. pmc Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death
    Samuel H McCall
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina, USA
    J Bone Miner Res 23:30-40. 2008
    ..We provide evidence for the functional expression in osteoblasts of NLRP3, a member of the NLR family of cytosolic receptors that has been implicated in the initiation of programmed cell death...
  58. pmc Structural basis of murein peptide specificity of a gamma-D-glutamyl-l-diamino acid endopeptidase
    Qingping Xu
    Joint Center for Structural Genomics, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA
    Structure 17:303-13. 2009
    ..The NlpC/P60 domain is a primitive, papain-like peptidase in the CA clan of cysteine peptidases with a Cys126/His176/His188 catalytic triad and a conserved catalytic core...
  59. ncbi ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection
    Joao H F Pedra
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 179:4783-91. 2007
    ..phagocytophilum. The NLR family member IPAF/NLRC4, but not NALP3/NLRP3, was partially required for IFN-gamma production in response to A. phagocytophilum...
  60. ncbi Incest in Palau: "Delemumuu undressed"
    Stevenson Kuartei
    Ministry of Health, Republic of Palau
    Pac Health Dialog 12:84-91. 2005
    ..It is the level of kebliil where incest is defined and could differ from clan to clan...
  61. doi Cysteine peptidase expression in Trichomonas vaginalis isolates displaying high- and low-virulence phenotypes
    Jose Batista De Jesus
    Departamento de Ciencias Naturais, Universidade Federal de Sao Joao del Rei, Sao Joao Del Rei, MG, Brazil
    J Proteome Res 8:1555-64. 2009
    ..Seven of the eight CPs identified belong to Clan CA, family C1, cathepsin L-like CP, and one belongs to Clan CD, family C13, asparaginyl endopeptidase-like CP...
  62. ncbi Transcriptional activation by the sexual pheromone and wounding: a new gene family from Volvox encoding modular proteins with (hydroxy)proline-rich and metalloproteinase homology domains
    A Hallmann
    Lehrstuhl Biochemie I, Universitat Regensburg, Universitätstr 31, D 93053 Regensburg, Germany
    Plant J 26:583-93. 2001
    ..Sequence comparisons suggest that the VMPs are members of the MB clan of zinc-dependent matrix metalloproteinases, although the putative zinc binding site of all VMPs is QEXXHXXGXXH ..
  63. ncbi Structural aspects of the metzincin clan of metalloendopeptidases
    F Xavier Gomis-Ruth
    Institut de Biologia Molecular de Barcelona, CID CSICC Jordi Girona, 18 26 08034 Barcelona, Spain
    Mol Biotechnol 24:157-202. 2003
    ..All these structural features identify the metzincin clan of metalloendopeptidases...
  64. ncbi Identification of acceptor substrate binding subsites +2 and +3 in the amylomaltase from Thermus thermophilus HB8
    Thijs Kaper
    Centre for Carbohydrate Bioprocessing TNO, University of Groningen, 9751 NN Haren, The Netherlands
    Biochemistry 46:5261-9. 2007
    Glycoside hydrolase family 77 (GH77) belongs to the alpha-amylase superfamily (Clan H) together with GH13 and GH70...
  65. doi Minimal motif peptide structure of metzincin clan zinc peptidases in micelles
    Akira Onoda
    Faculty of Science, Department of Chemistry, Tokyo University of Science, Kagurazaka 1 3, Shinjuku ku, Tokyo 162 8601, Japan
    J Pept Sci 15:832-41. 2009
    ..In this study, we focused our attention on the zinc-binding motif of the metzincin clan family, HEXXHXXGXXH; this family contains the general zinc-binding sequence His-Glu-Xaa-Xaa-His (HEXXH) and the ..
  66. pmc Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila
    Kristina A Archer
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Infect Immun 78:2477-87. 2010
    ..Rip2 and Naip5/NLRC4 signaling was found to contribute to the innate immune response generated against L. pneumophila in the lung...
  67. pmc Dexamethasone-associated cross-linked actin network formation in human trabecular meshwork cells involves β3 integrin signaling
    Mark S Filla
    Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison, USA
    Invest Ophthalmol Vis Sci 52:2952-9. 2011
    ....
  68. ncbi "When the obvious brother is not there": political and cultural contexts of the orphan challenge in northern Uganda
    Christopher Oleke
    Centre for International Health University of Bergen, Armauer Hansens Building, N 5021 Bergen, Norway
    Soc Sci Med 61:2628-38. 2005
    ..but rather by marginalised widows, grandmothers or other single women receiving little support from the paternal clan. This transition is partly linked to an abrupt discontinuation of the Langi 'widow inheritance' (laku) practice...
  69. pmc The cytochrome P450 (CYP) gene superfamily in Daphnia pulex
    William S Baldwin
    Clemson University, Biological Sciences, Institute of Environmental Toxicology, Pendleton, SC, USA
    BMC Genomics 10:169. 2009
    ..The latter form a critical component of detoxification systems...
  70. ncbi Role of loop structures of neuropsin in the activity of serine protease and regulated secretion
    Takuya Oka
    Division of Structural Cell Biology and Division of Structural Biology, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara, Japan
    J Biol Chem 277:14724-30. 2002
    Neuropsin involved in neural plasticity in adult mouse brain is a member of the S1 (clan SA) family of serine proteases and forms characteristic surface loops surrounding the substrate-binding site (Kishi, T., Kato, M., Shimizu, T...
  71. ncbi The many selves of social insects
    David C Queller
    Department of Ecology and Evolutionary Biology, Mail Stop 170, Rice University, Post Office Box 1892, Houston, TX 77251 1892, USA
    Science 296:311-3. 2002
    ..Transfer of these odors within the colony obscures separate clan identities...
  72. pmc Expression and characterization of cathepsin P
    Robert W Mason
    Department of Biomedical Research, Alfred I duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE 19803, USA
    Biochem J 378:657-63. 2004
    The mouse genome contains a family of clan C1A proteases that appear to be restricted to rodents within Eutherian (placental) mammals. mRNA analysis has shown that these genes are expressed exclusively in placenta...
  73. pmc Structure of a class II TrmH tRNA-modifying enzyme from Aquifex aeolicus
    Elizabeth Pleshe
    Department of Chemistry and Biochemistry, University of Colorado, Campus Box 215, Boulder, CO 80309 0215, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 61:722-8. 2005
    ..The protein reveals a fold typical of members of the SpoU clan of proteins, a subfamily of the alpha/beta-knot superfamily, with alpha-helical extensions at the N- and C-termini ..
  74. ncbi Probing nature's knots: the folding pathway of a knotted homodimeric protein
    Anna L Mallam
    Chemistry Department, Cambridge, UK
    J Mol Biol 359:1420-36. 2006
    ..Members of the alpha/beta-knot clan form deep trefoil knots in their native backbone structure, a topological feature that is currently unexplained in ..
  75. doi The carbohydrate-binding module family 20--diversity, structure, and function
    Camilla Christiansen
    VKR Research Centre Pro Active Plants, Department of Plant Biology and Biotechnology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark
    FEBS J 276:5006-29. 2009
    ..The clear evolutionary relatedness of CBM20s to CBM21s, CBM48s and CBM53s suggests a common clan hosting most of the known SBDs...
  76. doi Structure, expression and function of Allomyces arbuscula CDP II (metacaspase) gene
    Mukti Ojha
    Department of Biochemistry, University of Geneva, Sciences II, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    Gene 457:25-34. 2010
    ..shown that the protein belongs to a newly described member of caspase superfamily protein, the metacaspase, a CD clan of C14 family cysteine protease, we hence-forth name it as AMca 2 (Allomyces metacaspase 2)...
  77. doi Arthropod CYPomes illustrate the tempo and mode in P450 evolution
    R Feyereisen
    UMR1301 INRA CNRS Universite de Nice Sophia Antipolis, 400 Route des Chappes, 06903 Sophia Antipolis, France
    Biochim Biophys Acta 1814:19-28. 2011
    ..Mitochondrial clan P450s are a monophyletic group of genes that has seen several blooms in insects, but apparently not in vertebrates.
  78. pmc Neighborhood rough set reduction-based gene selection and prioritization for gene expression profile analysis and molecular cancer classification
    Mei Ling Hou
    Intelligent Computing Laboratory, Hefei Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, Anhui, China
    J Biomed Biotechnol 2010:726413. 2010
    ..Comparison with other methods such as PAM, ClaNC, Kruskal-Wallis rank sum test, and Relief-F, our method shows that only few top-ranked genes could achieve higher ..
  79. doi Consolidation of glycosyl hydrolase family 30: a dual domain 4/7 hydrolase family consisting of two structurally distinct groups
    Franz J St John
    University of Maryland, School of Pharmacy, Department of Pharmaceutical Sciences, Baltimore, MD, USA
    FEBS Lett 584:4435-41. 2010
    ..For this CAZy family of Clan A enzymes the dual domain fold is conserved, suggesting that it may be a requirement for evolved function...
  80. doi Snake venom metalloproteinases: structure, function and relevance to the mammalian ADAM/ADAMTS family proteins
    Soichi Takeda
    Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Fujishiro dai, Suita, Osaka, Japan
    Biochim Biophys Acta 1824:164-76. 2012
    ..and ADAMTS (ADAM with thrombospondin type-1 motif) family of proteins and, together with them, constitute the M12B clan of metalloendopeptidases...
  81. ncbi N3 call types produced long-term by a killer whale of the northern resident community under controlled conditions: Characteristics, variation, and behavioral context
    Juliette S Nash
    Dept of Mar and Env Sci, Univ of San Diego, 5998 Alcala Park, San Diego, CA 92110
    J Acoust Soc Am 130:2358. 2011
    A-Clan of the Northern Resident killer whale (Orcinus orca) community produces a dialect of discrete stereotyped vocalizations, including N3, a call found in all pods of the clan...
  82. pmc A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans
    Jeffrey Tomalka
    Center for Global Health and Diseases, Case Western Reserve University, School of Medicine, Cleveland, Ohio, United States of America
    PLoS Pathog 7:e1002379. 2011
    ..Here we show that mucosal expression of NLRP3 and NLRC4 is induced by Candida infection, and up-regulation of these molecules is impaired in NLRP3 and NLRC4 deficient ..
  83. doi Biochemical regulation of the inflammasome
    Jennifer K Dowling
    Inflammation Research Group, School of Biochemistry and Immunology, Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland
    Crit Rev Biochem Mol Biol 47:424-43. 2012
    ..Here, we review current knowledge surrounding the biochemical regulation of the NLRP1, NLRP3, NLRC4, AIM2 and IFI16 inflammasomes.
  84. doi The recombinant prepro region of TvCP4 is an inhibitor of cathepsin L-like cysteine proteinases of Trichomonas vaginalis that inhibits trichomonal haemolysis
    Rosa Elena Cárdenas-Guerra
    Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional CINVESTAV IPN, Av IPN 2508, Col San Pedro Zacatenco, Delg Gustavo A Madero, CP 07360 Mexico, DF, Mexico
    Int J Biochem Cell Biol 59:73-83. 2015
    ..TvCP4 contains the prepro fragment and the catalytic triad that is typical of the papain-like CP family of clan CA...
  85. pmc AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3
    Adam Denes
    Laboratory of Molecular Neuroendocrinology, Institute of Experimental Medicine, Budapest, 1083, Hungary Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom and
    Proc Natl Acad Sci U S A 112:4050-5. 2015
    ..Here, using a rodent model of stroke, we show that the NLRC4 (NLR family, CARD domain containing 4) and AIM2 (absent in melanoma 2) inflammasomes contribute to brain injury...
  86. pmc Regulation and Function of the Nucleotide Binding Domain Leucine-Rich Repeat-Containing Receptor, Pyrin Domain-Containing-3 Inflammasome in Lung Disease
    Seonmin Lee
    1 Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Am J Respir Cell Mol Biol 54:151-60. 2016
    ..e., NLR family, pyrin domain containing [NLRP] 1, NLRP3, and NLR family, caspase recruitment domain containing-4 [NLRC4]) as well as the pyrin and hemopoietic expression, interferon-inducibility, nuclear localization domain-containing ..
  87. pmc The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation
    Xiaowei Wang
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Infect Immun 84:1796-805. 2016
    ..loop 2 of sialostatin L2, an anti-inflammatory tick protein, binds to annexin A2 and impairs the formation of the NLRC4 inflammasome during infection with the rickettsial agent Anaplasma phagocytophilum Macrophages deficient in ..
  88. pmc Involvement of the NLRC4-Inflammasome in Diabetic Nephropathy
    Fang Yuan
    Department of Nephrology, The Second Xiangya Hospital, Research Institute of Nephrology, Central South University, Changsha, Hunan China
    PLoS ONE 11:e0164135. 2016
    ..In an effort to understand other IL-1β activating mechanism during DN development, we examined the role of the NLRC4-inflammasome in DN and found that NLRC4 is a parallel mechanism, in addition to the NLRP3-inflammasome, to induce ..
  89. ncbi Association of Inflammasome Components in Background Liver with Poor Prognosis After Curatively-resected Hepatocellular Carcinoma
    Fuminori Sonohara
    Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Anticancer Res 37:293-300. 2017
    ..Inflammasomes are multiprotein complexes that evoke key inflammatory cascades. The present study evaluated the influence of inflammasome component expression in non-tumorous tissue on postsurgical hepatocellular carcinoma (HCC) prognosis...
  90. ncbi Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis
    B J Geddes
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Biochem Biophys Res Commun 284:77-82. 2001
    ..A novel human member of this family, called CARD12, was identified that induces apoptosis when expressed in cells...
  91. pmc Vocal clans in sperm whales (Physeter macrocephalus)
    L E Rendell
    Department of Biology, Dalhousie University, Halifax, Nova Scotia B3H 4J1, Canada
    Proc Biol Sci 270:225-31. 2003
    ..Units seem to form groups preferentially with other units of their own clan. We suggest that this is a rare example of sympatric cultural variation on an oceanic scale...
  92. ncbi Functional conservation of a natural cysteine peptidase inhibitor in protozoan and bacterial pathogens
    S J Sanderson
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Joseph Black Building, Glasgow G12 8QQ, UK
    FEBS Lett 542:12-6. 2003
    ..Recombinant forms of each ICP inhibit protozoan and mammalian clan CA, family C1 cysteine peptidases but do not inhibit the clan CD cysteine peptidase caspase 3, the serine peptidase ..
  93. ncbi Gingipains, the major cysteine proteinases and virulence factors of Porphyromonas gingivalis: structure, function and assembly of multidomain protein complexes
    Jan Potempa
    Department of Microbiology, Faculty of Biotechnology, Jagiellonian University, 30 387 Krakow, Poland
    Curr Protein Pept Sci 4:397-407. 2003
    ..evolutionary related to other highly specific proteinases including clostripain, caspases, legumains and separase (clan CD of cysteine peptidases)...
  94. ncbi PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1
    Yetao Wang
    Center for the Development of Molecular Target Drugs, Cancer Research Institute, Kanazawa University, Kanazawa 920 0934, Japan
    Int Immunol 16:777-86. 2004
    ..IL-1beta maturation, and it does so in the presence and absence of constitutively active mutants of CARD12 and PYPAF1, which are enhancers of these processes. Thus, PYNOD is a novel regulator of apoptosis and inflammation.
  95. doi The fourth level of social structure in a multi-level society: ecological and social functions of clans in hamadryas baboons
    Amy L Schreier
    Department of Evolutionary Anthropology, Duke University, Durham, North Carolina 27708, USA
    Am J Primatol 71:948-55. 2009
    ..All band fissions occurred along clan lines, and most takeovers involved the transfer of females within the same clan...
  96. pmc The structure of DinB from Geobacillus stearothermophilus: a representative of a unique four-helix-bundle superfamily
    David R Cooper
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 66:219-24. 2010
    ..The structural similarities of these diverse proteins suggest that a new Pfam clan encompassing the families that share this fold should be created...
  97. pmc Crystal structure and mutational analysis of aminoacylhistidine dipeptidase from Vibrio alginolyticus reveal a new architecture of M20 metallopeptidases
    Chin Yuan Chang
    Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 30010, Taiwan
    J Biol Chem 285:39500-10. 2010
    ..4.13.3) belong to the family of M20 metallopeptidases from the metallopeptidase H clan that catalyze a broad range of dipeptide and tripeptide substrates, including L-carnosine and L-homocarnosine...
  98. pmc Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog
    Theodoros Goulas
    Proteolysis Lab, Department of Structural Biology, Molecular Biology Institute of Barcelona, Consejo Superior de Investigaciones Cientificas, Barcelona Science Park, Helix Building, E 08028 Barcelona, Spain
    Proc Natl Acad Sci U S A 108:1856-61. 2011
    ..is active against several protein substrates and its structure reveals a new family prototype within the metzincin clan of metallopeptidases...
  99. pmc Structural and kinetic insights reveal that the amino acid pair Gln-228/Asn-254 modulates the transfructosylating specificity of Schwanniomyces occidentalis β-fructofuranosidase, an enzyme that produces prebiotics
    Miguel Alvaro-Benito
    Centro de Biologia Molecular Severo Ochoa, Departamento de Biologia Molecular, Universidad Autónoma de Madrid Consejo Superior de Investigaciones, Cantoblanco, 28049 Madrid, Spain
    J Biol Chem 287:19674-86. 2012
    ..The results contribute to an understanding of the molecular basis regulating specificity among GH-J clan members, which represent an interesting target for rational design of enzymes, showing redesigned activities to ..
  100. pmc Spontaneous formation of IpaB ion channels in host cell membranes reveals how Shigella induces pyroptosis in macrophages
    L Senerovic
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Chariteplatz 1, D 10117 Berlin, Germany
    Cell Death Dis 3:e384. 2012
    ..These data may explain how S. flexneri uses secreted IpaB to escape phagosome and kill the host cells during infection and, may be extended to homologs from other medically important enteropathogenic bacteria...
  101. doi Caregiving of children with intellectual disabilities in China--an examination of affiliate stigma and the cultural thesis
    M Y L Chiu
    Department of Social Work, National University of Singapore, Singapore
    J Intellect Disabil Res 57:1117-29. 2013
    ..There is little literature on caregivers in China, where familial and clan responsibility rather than individual effort is emphasised, and where communal support, while treasured, is often ..

Research Grants58

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. Gabriel Nunez; Fiscal Year: 2015
    ..NLR family members including NOD1, NOD2, NLRC4 and NLRP3 are intracellular proteins that are involved in the recognition of microbial components and activation ..
  3. Molecular mechanisms of pathogen recognition by the Nod-like receptor NLRC4
    Fayyaz S Sutterwala; Fiscal Year: 2012
    ..aeruginosa are required. In this proposal we will examine the role of the NOD-like receptor (NLR) family member NLRC4 in recognition and response to infection with P. aeruginosa...
  4. Gabriel Nunez; Fiscal Year: 2016
    ..The activation of caspase-1 is controlled by members of the intracellular NOD-like receptor (NLR) family including NLRC4 and NLRP3...
  5. Samithamby Jeyaseelan; Fiscal Year: 2016
    ..We have previously shown the NLR family CARD domain containing 4 (NLRC4;IPAF) as a new sensor to K...
  6. Shawn J Skerrett; Fiscal Year: 2016
    ..This aim will test the hypothesis that muted function of the NLRC4 inflammasome underlies the susceptibility of human AM to parasitism by Lp...
  7. Sanjay Batra; Fiscal Year: 2016
    ..and human alveolar macrophages as well as murine lungs;3) as compared to other NLRs (NOD1, NOD2, NLRP1, NLRP3, and NLRC4), NLRP12 activation leads to much higher production of IL-1[unreadable], IL-18 and IL-17 in murine lungs following ..
  8. Role of caspases in Legionella pneumophila pulmonary infection
    Amal O Amer; Fiscal Year: 2013
    ..pneumophila with the exception of mice lacking Ipaf, caspase-1 or harboring a mutant Naip5 gene...
  9. Igor E Brodsky; Fiscal Year: 2014
    ..Activation of inflammasomes by Salmonella involves sensing of bacterial flagellin by NLRC4, and sensing of an unknown bacterial signal by NLRP3...
  10. How can caspases control intracellular pulmonary pathogens
    Amal O Amer; Fiscal Year: 2010
    ..Whereas most mouse strains are resistant to Legionella with the exception of the A/J, caspase-1-/- and Ipaf-/- mice...
  11. Edward A Miao; Fiscal Year: 2016
    ..Some NLRs, including NLRP3 and NLRC4, form inflammasomes that recruit and activate Caspase-1, a protease that subsequently cleaves the inflammatory ..
  12. Pulmonary Pathogen-Recognition Pathways in Melioidosis
    TIMOTHY EOIN WEST; Fiscal Year: 2013
    ..innate and adaptive immunity;and 3) to determine the related role of the cytosolic ICE-protease-activating factor (IPAF)/caspase-1 signaling axis in melioidosis. In performing these studies, Dr. West will be closely supervised by Dr...
  13. Russell E Vance; Fiscal Year: 2016
    ..To address these questions, our studies have focused on a sub-family of inflammasomes called the Naip/Nlrc4 inflammasomes...
  14. Yeast-based HTS Assay Technologies for Proteases
    John C Reed; Fiscal Year: 2012
    ..in which compounds will be identified and optimized that selectively inhibit the upstream Caspase-1 activator NLRC4 (Ipaf1;CLAN), a component of innate immunity and critical regulator of host responses to intracellular bacterial ..
  15. Craig R Roy; Fiscal Year: 2015
    ..Host pattern recognition system controlled by the adapter proteins MyD88, Rip2, NLRC4, and Naip5 have been shown to trigger innate immune responses to L. pneumophila...
  16. Listeria-based vaccines engineered to modulate the innate immune system
    Daniel A Portnoy; Fiscal Year: 2011
    ..inflammasome, while another strain secretes an ActA-flagellin (ActA-Fla) fusion protein and activates a NLRC4-dependent inflammasome...
  17. Control of intestinal microflora and inflammation by immune sensing of flagellin
    Janelle S Ayres; Fiscal Year: 2012
    ..mouse mutants deficient for the function of two flagellin-sensing proteins of the innate immune response, Naip5 and Ipaf, were found to be resistant to colitis compared to wild type mice...
  18. The role of NALPs in innate immunity
    Fayyaz S Sutterwala; Fiscal Year: 2010
    ..2) Determining how NALPS and IPAF can direct the activity of caspase-1 towards cytokine processing and/or cell death...
  19. ANDREW T KENT; Fiscal Year: 2015
    ..Here we will look at two members of this family of receptors, NLRC4 (also known as IPAF) and NAIP5, which are known to synergize with ASC for pro-inflammatory signaling in response ..
  20. Zuni MI/CRA Project
    Kamilla L Venner; Fiscal Year: 2010
    ..tribal communication norms, and CRA is particularly well suited to make use of the extended family and unique clan structure of reservation life...
  21. Organizational Culture's Impact Across the Nursing Home Industry
    Jane Banaszak Holl; Fiscal Year: 2009
    ..four scale variables that measure the intensity of four types of values defined by the CVF: market, hierarchical, clan and adhocratic values, where clan- oriented values are those most strongly associated with the culture change ..
  22. Role of Ipaf in Inflammation and Host Defense
    Gabriel Nunez; Fiscal Year: 2009
    ..b>Ipaf is another NOD family member highly related to NOD1 and NOD2...
  23. Development of a High-Throughput Assay for Human Desumoylating Enzymes [SENPs]
    Guy Salvesen; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The human peptidase clan CE is defined by seven proteases with a common fold and catalytic mechanism, commonly known as SENPs (sentrin specific proteases - sentrin being an alternative ..
  24. CHILDES 91: WORKSHOP ON AUTOMATED TRANSCRIPT ANALYSIS
    Catherine Snow; Fiscal Year: 1991
    ..in CHAT, the system transcription manual), and c) a set of programs for manipulating and analyzing transcript data (CLAN, which stands for Child Language Analysis)...
  25. Arthritis Research Conference 2005
    Gregg Silverman; Fiscal Year: 2005
    ..abstract_text> ..
  26. RHEUMATIC DISEASES CORE CENTER
    Gregg Silverman; Fiscal Year: 2006
    ..An Administrative Core (PI-G.J. Silverman, Center Director) will provide overall direction and supervision to all Center programs through an Executive Committee, which will be assisted by an Outside Advisory Committee. ..
  27. alpha4beta1 Intergrin Signaling In Immunity And Arthritis
    GREGG JOSHUA SILVERMAN; Fiscal Year: 2010
    ..Collectively, this work will provide insight into the role of the ct4-paxillin interaction in inflammation and immunity, and whether this interaction is a potential bona fide therapeutic target for arthritis. ..
  28. Cell Death and Antibody-Mediated Protection from Autoimmunity
    GREGG JOSHUA SILVERMAN; Fiscal Year: 2010
    ....
  29. Mechanisms to Induce Protective Natural Autoimmunity
    Gregg Silverman; Fiscal Year: 2004
    ..abstract_text> ..
  30. B CELL SUPERANTIGENS AND IMMUNE REGULATION
    Gregg Silverman; Fiscal Year: 2008
    ..In addition, these studies will lead to a better understanding of the immunobiologic activities of a virulence factor from one of the most important causes of life-threatening infection in the US. ..
  31. Arthritis Research Conference 2007
    Gregg Silverman; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  32. Ipaf signaling in innate immunity
    EDWARD MIAO; Fiscal Year: 2008
    ..In this proposal we will focus on Ipaf, a Nod/Nalp family member. Ipaf activates NF-KappaB and Caspase 1 in immune cells...
  33. CONTROLS FOR ASSOCIATION STUDIES OF ALCOHOLISM
    Kenneth Kidd; Fiscal Year: 2009
    ..Indications of the importance to alcoholism of different genetic variants and of which haplotypes may harbor cryptic but functionally relevant variation will result from these studies. ..
  34. Autophagy in Tuberculosis
    VOJO P DERETIC; Fiscal Year: 2011
    ..Our studies will provide novel pharmacological and immunological approaches in treatment and prophylaxis of tuberculosis, with strong implications for immunity and infectious diseases in general. ..
  35. MECHANISM OF INTERFERON ACTION
    CHARLES SAMUEL; Fiscal Year: 2009
    ..Furthermore, elucidation of the actions of IFN at the molecular level is of importance in view of potential applications of interferon in the clinic. ..
  36. PEPTIDE SYNTHESIZER
    Sherwin Wilk; Fiscal Year: 2001
    ..The instrument will be operated and maintained by Dr. Imre Wolf, an accomplished peptide chemist and instrumentation specialist who has operated the Mount Sinai Core facility Milligen peptide synthesizer. ..
  37. Induction of breast cancer in MMTVneu mice
    William Baldwin; Fiscal Year: 2002
    ..Overall, the purpose of this study is to examine 4-nonylphenol's effects on breast cancer growth and its mechanism of action on the mammary tumor. ..
  38. BIOSYNTHESIS OF BETA LACTAM ANTIBIOTICS
    Craig Townsend; Fiscal Year: 2003
    ..These insights will be extended to examination of beta- lactam formation in the prephytotoxin tabtoxin. ..
  39. EVALUATION OF FALCIPAIN AS AN ANTIMALARIAL DRUG TARGET
    Philip Rosenthal; Fiscal Year: 2003
    ..This evaluation is also likely to identify specific falcipain inhibitors with potent antimalarial activity that will be ready for initial testing against human malaria. ..
  40. Nod1: An Apaf-like Activator of Apoptosis and NF-kB
    Naohiro Inohara; Fiscal Year: 2005
    ..We propose three Specific Aims to understand the biochemical mechanism by which bacterial LPS and Nod1 interact and to determine the role of Nod1 in the response to bacterial LPS in vivo. ..
  41. Falcipain Cysteine Proteases of Malaria Parasites
    Philip Rosenthal; Fiscal Year: 2005
    ..Experiments designed to accomplish these aims should improve our understanding of the biology of malaria parasites and aid in the characterization of falcipains as potential drug targets. ..
  42. Hyperacidification and Pseudomonas infections in CF
    Vojo Deretic; Fiscal Year: 2006
    ..abstract_text> ..
  43. BRAIN ENDOPEPTIDASES AND NEUROPEPTIDE METABOLISM
    Sherwin Wilk; Fiscal Year: 2001
    ....
  44. 400 MHz NMR Spectrometer for Shared Use
    Craig Townsend; Fiscal Year: 2004
    ..9) investigation of the hypothesis that aromatic amino acids are required to specify a distinct conformational state by NMR spin relaxation techniques, to elucidate important parameters for protein design. ..
  45. The Type III Pathway of Yersinia Pestis
    Olaf Schneewind; Fiscal Year: 2004
    ..Together these studies are also aimed at identifying molecular targets for drug therapies, an important area of research to aid in the defense against biological warfare and bioterrorist deployment of the select agent Y. pestis. ..
  46. Innate Immune Detection of Intracellular Pathogens
    RUSSELL VANCE; Fiscal Year: 2005
    ....
  47. Modulation of Host Cell Functions by Coxiella burnetii
    Craig R Roy; Fiscal Year: 2010
    ..These studies will elucidate pathogenic determinants that allow host cell infection by Coxiella and reveal intracellular infection strategies employed by this important pathogen. ..
  48. Pseudomonas in Cystic Fibrosis-Regulation of Mucoidy
    Vojo Deretic; Fiscal Year: 2006
    ..These studies are expected to improve our understanding of respiratory pathogenesis in CF, and lead to new treatments of presently incurable lung infections associated with this disease...
  49. Interaction of Yersinia with dendritic cells
    Igor Brodsky; Fiscal Year: 2007
    ..This knowledge will be important in the development of future strategies against human pathogens. ..
  50. DEVELOPING AN ISRAELI VERSION OF THE HRS/SHARE PROJECT
    Howard Litwin; Fiscal Year: 2006
    ..abstract_text> ..
  51. Innate immune resistance to intracellular bacterial pathogens
    RUSSELL VANCE; Fiscal Year: 2007
    ..Naip5 exhibits homology to a large family of cytosolic pathogen-detector proteins that also includes Ipaf, Nods and Nalps...
  52. Archiving the Data from the First Wave of SHARE-Israel
    Howard Litwin; Fiscal Year: 2007
    ..The data address key economic and social factors that contribute to health among people 50 years of age and older, providing unique opportunities for cross-national comparisons. [unreadable] [unreadable] [unreadable] [unreadable]..
  53. LINKAGE DISEQUILIBRIUM AND HUMAN GENETIC STUDIES
    Kenneth Kidd; Fiscal Year: 2008
    ..The data will be made publicly available through ALFRED, an existing Web-accessible database. ..
  54. Mechanism of M. tuberculosis Phagosome Maturation Arrest
    Vojo Deretic; Fiscal Year: 2008
    ..tuberculosis and provide a foundation for new interventions potentially combating both active disease and latent infection. ..
  55. LcrV Plague Vaccine with Altered Immune Modulatory Properties
    Olaf Schneewind; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  56. Clinical & Molecular Studies of Drug Resistant Malaria
    Philip Rosenthal; Fiscal Year: 2008
    ..abstract_text> ..
  57. Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies
    Philip Rosenthal; Fiscal Year: 2008
    ..abstract_text> ..