NK10

Summary

Gene Symbol: NK10
Description: ZFP90 zinc finger protein
Alias: FIK, NK10, ZNF756, zfp-90, zinc finger protein 90 homolog, FOXP3-interacting KRAB domain-containing protein, zinc finger protein 476, zinc finger protein 756
Species: human

Top Publications

  1. pmc Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure
    Jairam R Lingappa
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e28632. 2011
  2. pmc Large-scale East-Asian eQTL mapping reveals novel candidate genes for LD mapping and the genomic landscape of transcriptional effects of sequence variants
    Maiko Narahara
    Statistical Genetics, Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 9:e100924. 2014
  3. pmc CDH1 rs9929218 variant at 16q22.1 contributes to colorectal cancer susceptibility
    Peng Han
    Department of Colorectal Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, 150040, China
    Oncotarget 7:47278-47286. 2016
  4. doi 16q22.1 microdeletion detected by array-CGH in a family with mental retardation and lobular breast cancer
    Chiara Palka Bayard de Volo
    Department of Pediatrics, G D Annunzio University, Chieti, Italy
    Gene 498:328-31. 2012
  5. doi Identification of the bacteriocin subtilosin A and loss of purL results in its high-level production in Bacillus amyloliquefaciens
    Quanli Liu
    The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China
    Res Microbiol 163:470-8. 2012
  6. ncbi Developmentally regulated mouse gene NK10 encodes a zinc finger repressor protein with differential DNA-binding domains
    R Lange
    Institut fur Genetik, Universitat zu Koln, Germany
    DNA Cell Biol 14:971-81. 1995
  7. ncbi Biological activity of mammalian transcriptional repressors
    G Thiel
    Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical School, Homburg, Germany
    Biol Chem 382:891-902. 2001
  8. ncbi Effect of general and epidural anaesthesia on thyroid hormones and immunity in neonates
    A Gasparoni
    Research Laboratories, Policlinico San Matteo, IRCCS, Pavia, Italy
    Paediatr Anaesth 12:59-64. 2002
  9. ncbi Spastic paraplegia, optic atrophy, and neuropathy is linked to chromosome 11q13
    Lucia I Macedo-Souza
    Department of Biology, Institute of Biological Sciences and Center for Study of Human Genome, University of Sao Paulo, Brazil
    Ann Neurol 57:730-7. 2005
  10. pmc Gene modulation associated with inhibition of liver regeneration in hepatitis B virus X transgenic mice
    Malgorzata Sidorkiewicz
    INSERM Institut National de la Sante et de la Recherche Medicale U845, CHU Necker, 156 rue de Vaugirard, Paris 75015, France
    World J Gastroenterol 14:574-81. 2008

Scientific Experts

  • Quanli Liu
  • J Lingappa
  • Chiara Palka
  • A Sicilia
  • J L McClay
  • Luis G Carvajal-Carmona
  • Peng Han
  • Maiko Narahara
  • Chiara Palka Bayard de Volo
  • Leo Hata
  • Yan A Wang
  • Malgorzata Sidorkiewicz
  • Lucia I Macedo-Souza
  • Youling Yan
  • Guiyou Liu
  • Xiaobo Li
  • Jing Zou
  • Xin Lu
  • Guangyu Wang
  • Minmin Cao
  • Koichiro Higasa
  • Fumihiko Matsuda
  • Yasuharu Tabara
  • A Gasparoni
  • Kenichi Matsubara
  • Takahisa Kawaguchi
  • Miho Ishii
  • Seiji Nakamura
  • Ryo Yamada
  • Liborio Stuppia
  • G Thiel
  • Laura Bernardini
  • Ivana Antonucci
  • Giuseppe Calabrese
  • Francesco Chiarelli
  • Donatella Fantasia
  • Domenico Angelucci
  • Melissa Alfonsi
  • Robert Zori
  • Valentina Gatta
  • Antonio Novelli
  • Yoshihiro Kuwabara
  • Hideyuki Kinoshita
  • Shinji Yasuno
  • Takeya Minami
  • Kazuhiro Nakao
  • Koichiro Kuwahara
  • Kenji Ueshima
  • Masao Murakami
  • Satoru Usami
  • Yuko Yamada
  • Yasuaki Nakagawa
  • Chinatsu Yamada
  • Toshio Nishikimi
  • Masataka Fujiwara
  • Kazuwa Nakao
  • Zhao L Fei
  • Jian W Zheng
  • Jian Fei
  • Zhi Y Zhang
  • Zhu G Wang
  • Wan T Chen
  • Xin Q Jiang
  • Carlo Giannini
  • Jean Philippe Jais
  • Patrick Soussan
  • Serban Morosan
  • Nicolas Brezillon
  • Guilherme Tralhao
  • Dina Kremsdorf
  • Oona Delpuech
  • Alessandra Starling
  • Simone C Amorim
  • Angelina M M Lino
  • Silvana Santos
  • Agnes Nishimura
  • Karina Lezirovitz
  • Fernando Kok
  • Mayana Zatz
  • G Rondini
  • M Autelli
  • G Chirico
  • A Bartoli
  • E Polito
  • L Ciardelli
  • A M Castellazzi
  • D De Amici
  • R Bottino
  • K Bach
  • G Cibelli

Detail Information

Publications16

  1. pmc Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure
    Jairam R Lingappa
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e28632. 2011
    ..To minimize misclassification of HIV-1 risk, we quantified HIV-1 exposure, using data including plasma HIV-1 concentrations, gender, and condom use...
  2. pmc Large-scale East-Asian eQTL mapping reveals novel candidate genes for LD mapping and the genomic landscape of transcriptional effects of sequence variants
    Maiko Narahara
    Statistical Genetics, Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    PLoS ONE 9:e100924. 2014
    ..2E-11) for Parkinson's disease. We identified four genes (P<2.0E-14) that might be related to three diseases and two hematological traits; each expression is regulated by trans-eQTLs on a different chromosome than the gene. ..
  3. pmc CDH1 rs9929218 variant at 16q22.1 contributes to colorectal cancer susceptibility
    Peng Han
    Department of Colorectal Surgery, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, 150040, China
    Oncotarget 7:47278-47286. 2016
    ..2 and MCOLN2 by both cis-effect and trans-effect. In summary, our analysis highlights significant association between rs9929218 polymorphism and CRC susceptibility...
  4. doi 16q22.1 microdeletion detected by array-CGH in a family with mental retardation and lobular breast cancer
    Chiara Palka Bayard de Volo
    Department of Pediatrics, G D Annunzio University, Chieti, Italy
    Gene 498:328-31. 2012
    ..Furthermore, we suggest that the deletion of the CDH1, a tumor suppressor gene, involved in hereditary diffuse gastric cancer (HDGC) and LBC predisposed the mother to the carcinoma...
  5. doi Identification of the bacteriocin subtilosin A and loss of purL results in its high-level production in Bacillus amyloliquefaciens
    Quanli Liu
    The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China
    Res Microbiol 163:470-8. 2012
    A mini-Tn10 transposon mutagenesis library of strain Bacillus amyloliquefaciens BAhja NK10 was constructed and one mutant, L4, exhibiting markedly enhanced antagonistic activity against Micrococcus luteus, was screened and possessed an ..
  6. ncbi Developmentally regulated mouse gene NK10 encodes a zinc finger repressor protein with differential DNA-binding domains
    R Lange
    Institut fur Genetik, Universitat zu Koln, Germany
    DNA Cell Biol 14:971-81. 1995
    ..The NK10 KRAB domains exhibit repressing activity when tested in GAL4 fusion protein assays...
  7. ncbi Biological activity of mammalian transcriptional repressors
    G Thiel
    Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical School, Homburg, Germany
    Biol Chem 382:891-902. 2001
    ..The repressors studied were: REST, the thyroid hormone receptors alpha and beta, the zinc finger protein NK10 containing a 'krüppel-associated box' (KRAB), repressor domains derived from the proteins Egr-1, Oct2A and Dr1 ..
  8. ncbi Effect of general and epidural anaesthesia on thyroid hormones and immunity in neonates
    A Gasparoni
    Research Laboratories, Policlinico San Matteo, IRCCS, Pavia, Italy
    Paediatr Anaesth 12:59-64. 2002
    ..The aim of this study was to verify if variations of thyroid hormones related to circumstances of delivery and mode of maternal anaesthesia can contribute to neonatal neutrophil respiratory burst and natural killer cell activity...
  9. ncbi Spastic paraplegia, optic atrophy, and neuropathy is linked to chromosome 11q13
    Lucia I Macedo-Souza
    Department of Biology, Institute of Biological Sciences and Center for Study of Human Genome, University of Sao Paulo, Brazil
    Ann Neurol 57:730-7. 2005
    ..8Mb and has more than 100 genes and expressed sequences. We propose the acronym SPOAN (spastic paraplegia, optic atrophy, and neuropathy) for this complex syndrome...
  10. pmc Gene modulation associated with inhibition of liver regeneration in hepatitis B virus X transgenic mice
    Malgorzata Sidorkiewicz
    INSERM Institut National de la Sante et de la Recherche Medicale U845, CHU Necker, 156 rue de Vaugirard, Paris 75015, France
    World J Gastroenterol 14:574-81. 2008
    ..To analyze the modulation of gene expression profile associated with inhibition of liver regeneration in hepatitis B X (HBx)-expressing transgenic mice...
  11. doi Immediate efficacy of diode laser application in the treatment of dentine hypersensitivity in periodontal maintenance patients: a randomized clinical trial
    Alberto Sicilia
    Clinica Sicilia, Oviedo, Spain
    J Clin Periodontol 36:650-60. 2009
    To evaluate the immediate efficacy in the reduction of dentine hypersensitivity (DH) when applying an 810 nm diode laser (DL), and a 10% potassium nitrate bioadhesive gel (NK10%).
  12. pmc Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia
    Joseph L McClay
    Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 0533, USA
    Neuropsychopharmacology 36:616-26. 2011
    ..This study has generated several novel candidate genes for antipsychotic response. However, our findings will require replication and functional validation. To facilitate replication efforts, we provide all GWAS p-values for download...
  13. doi Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes
    Leo Hata
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    J Mol Cell Cardiol 50:972-81. 2011
    ..Collectively, these results suggest that Zfp90 functions as a negative regulator of NRSF and contributes to genetic remodeling during the development of cardiac dysfunction...
  14. doi Construction of novel conditional transgenic vectors for molecular therapy based on the Tet-On system and flanked with insulators in a single plasmid
    Yan A Wang
    Department of Oral and Maxillofacial Surgery, Ninth People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P R China
    Mol Med Report 2:799-803. 2009
    ..expression, the most powerful repressor domain containing a 'kruppel-associated box' of the zinc finger protein NK10 was used and fused to TetR in one of the two vectors...
  15. pmc Fine-mapping of colorectal cancer susceptibility loci at 8q23.3, 16q22.1 and 19q13.11: refinement of association signals and use of in silico analysis to suggest functional variation and unexpected candidate target genes
    Luis G Carvajal-Carmona
    Wellcome Trust Centre for Human Genetics and Department of Clinical Pharmacology, University of Oxford, Oxford, UK
    Hum Mol Genet 20:2879-88. 2011
    ..In addition, caution should be exercised when assigning functionality to candidate genes in regions discovered through GWA analysis...