NFKB2

Summary

Gene Symbol: NFKB2
Description: nuclear factor kappa B subunit 2
Alias: CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p100, p49/p100, p52, nuclear factor NF-kappa-B p100 subunit, DNA-binding factor KBF2, NFKB, p52/p100 subunit, lymphocyte translocation chromosome 10 protein, nuclear factor Kappa-B, subunit 2, nuclear factor NF-kappa-B p52 subunit, nuclear factor of Kappa light chain gene enhancer in B cells 2, nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100), oncogene Lyt-10, transcription factor NFKB2
Species: human

Top Publications

  1. pmc The cytoplasmic domain of the HIV-1 glycoprotein gp41 induces NF-κB activation through TGF-β-activated kinase 1
    Thomas S Postler
    New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, MA 01772 9102, USA
    Cell Host Microbe 11:181-93. 2012
  2. pmc Follicular dendritic cells and human immunodeficiency virus type 1 transcription in CD4+ T cells
    Tyler C Thacker
    Department of Chemistry and Biochemistry, Room C 211A BNSN, Brigham Young University, Provo, UT 84602, USA
    J Virol 83:150-8. 2009
  3. ncbi Hiv-1 Tat can substantially enhance the capacity of NIK to induce IkappaB degradation
    X Li
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Biochem Biophys Res Commun 286:587-94. 2001
  4. ncbi Extracellular HIV type 1 Tat protein induces CD69 expression through NF-kappaB activation: possible correlation with cell surface Tat-binding proteins
    M V Blazquez
    Departamento de Fisiología e Immunología, Universidad de Cordoba, Cordoba, Spain
    AIDS Res Hum Retroviruses 15:1209-18. 1999
  5. pmc Expression of MIS in the testis is downregulated by tumor necrosis factor alpha through the negative regulation of SF-1 transactivation by NF-kappa B
    Cheol Yi Hong
    Hormone Research Center, Chonnam National University, Gwangju 500 757, Republic of Korea
    Mol Cell Biol 23:6000-12. 2003
  6. pmc LMP1-augmented kappa intron enhancer activity contributes to upregulation expression of Ig kappa light chain via NF-kappaB and AP-1 pathways in nasopharyngeal carcinoma cells
    Haidan Liu
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Xiangya Road 110, Changsha, Hunan 410078, PR China
    Mol Cancer 8:92. 2009
  7. pmc Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line
    Masaya Higuchi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    J Virol 81:11900-7. 2007
  8. ncbi T cell activation-induced and HIV tat-enhanced CD95(APO-1/Fas) ligand transcription involves NF-kappaB
    M Li-Weber
    Tumor Immunology Program, German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Immunol 30:661-70. 2000
  9. ncbi The human immunodeficiency virus-1 Tat protein activates human umbilical vein endothelial cell E-selectin expression via an NF-kappa B-dependent mechanism
    Adela Cota-Gomez
    Webb Waring Institute for Cancer, Aging and Antioxidant Research, The Department of Microbiology, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:14390-9. 2002
  10. pmc HIV-1 Tat protein alter the tight junction integrity and function of retinal pigment epithelium: an in vitro study
    Ling Bai
    Key Laboratory of Ophthalmology, Ministry of Education Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, PR China
    BMC Infect Dis 8:77. 2008

Scientific Experts

Detail Information

Publications202 found, 100 shown here

  1. pmc The cytoplasmic domain of the HIV-1 glycoprotein gp41 induces NF-κB activation through TGF-β-activated kinase 1
    Thomas S Postler
    New England Primate Research Center, Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, MA 01772 9102, USA
    Cell Host Microbe 11:181-93. 2012
    ..These findings demonstrate an evolutionarily conserved role for gp41CD in activating NF-κB to promote infection...
  2. pmc Follicular dendritic cells and human immunodeficiency virus type 1 transcription in CD4+ T cells
    Tyler C Thacker
    Department of Chemistry and Biochemistry, Room C 211A BNSN, Brigham Young University, Provo, UT 84602, USA
    J Virol 83:150-8. 2009
    ..Therefore, in addition to providing an important reservoir of infectious virus, FDCs increase HIV production, contributing to a tissue microenvironment that is highly conducive to HIV transmission and expression...
  3. ncbi Hiv-1 Tat can substantially enhance the capacity of NIK to induce IkappaB degradation
    X Li
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Biochem Biophys Res Commun 286:587-94. 2001
    ..We propose a model to explain these collective experimental findings...
  4. ncbi Extracellular HIV type 1 Tat protein induces CD69 expression through NF-kappaB activation: possible correlation with cell surface Tat-binding proteins
    M V Blazquez
    Departamento de Fisiología e Immunología, Universidad de Cordoba, Cordoba, Spain
    AIDS Res Hum Retroviruses 15:1209-18. 1999
    ....
  5. pmc Expression of MIS in the testis is downregulated by tumor necrosis factor alpha through the negative regulation of SF-1 transactivation by NF-kappa B
    Cheol Yi Hong
    Hormone Research Center, Chonnam National University, Gwangju 500 757, Republic of Korea
    Mol Cell Biol 23:6000-12. 2003
    ..These results may identify, for the first time, the responsible substance and its action mechanism underlying the repression of MIS expression by meiotic germ cells in the testis...
  6. pmc LMP1-augmented kappa intron enhancer activity contributes to upregulation expression of Ig kappa light chain via NF-kappaB and AP-1 pathways in nasopharyngeal carcinoma cells
    Haidan Liu
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Xiangya Road 110, Changsha, Hunan 410078, PR China
    Mol Cancer 8:92. 2009
    ....
  7. pmc Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line
    Masaya Higuchi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    J Virol 81:11900-7. 2007
    ..In this study, we demonstrate that Tax1 but not Tax2 interacts with NF-kappaB2/p100 and activates it by inducing the cleavage of p100 into the active transcription factor p52...
  8. ncbi T cell activation-induced and HIV tat-enhanced CD95(APO-1/Fas) ligand transcription involves NF-kappaB
    M Li-Weber
    Tumor Immunology Program, German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Immunol 30:661-70. 2000
    ..Our studies provide evidence that Tat-enhanced CD95L expression is regulated at least in part by the NF-kappaB sites of the promoter...
  9. ncbi The human immunodeficiency virus-1 Tat protein activates human umbilical vein endothelial cell E-selectin expression via an NF-kappa B-dependent mechanism
    Adela Cota-Gomez
    Webb Waring Institute for Cancer, Aging and Antioxidant Research, The Department of Microbiology, School of Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:14390-9. 2002
    ..A super-repressor adenovirus (AdIkappaBalphaSR) that constitutively sequesters IkappaB in the cytoplasm as well as cycloheximide or actinomycin D inhibited Tat- or TNF-mediated kappaB translocation and E-selectin up-regulation...
  10. pmc HIV-1 Tat protein alter the tight junction integrity and function of retinal pigment epithelium: an in vitro study
    Ling Bai
    Key Laboratory of Ophthalmology, Ministry of Education Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, PR China
    BMC Infect Dis 8:77. 2008
    ..This study is to determine the effects of HIV-1 Tat proteins on the barrier function and tight-junction protein expression of retinal pigment epithelial cell (RPE)...
  11. pmc Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription
    J Liu
    Department of Internal Medicine, Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor 48109 0650
    J Virol 66:3883-7. 1992
    ..These findings suggest that the combination of p49(100) and p65 NF-kappa B can act in concert with the tat-I gene product to stimulate the synthesis of HIV RNA...
  12. pmc A Tat-induced auto-up-regulatory loop for superactivation of the human immunodeficiency virus type 1 promoter
    D K Biswas
    Division of Cell Growth and Regulation, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Virol 69:7437-44. 1995
    ..Thereby, multidrug modalities for transcription of HIV are proposed for virus suppression...
  13. pmc In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor
    K T Jeang
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 67:6224-33. 1993
    ..These experiments extend previous genetic experiments and suggest a direct interaction between Tat and Sp1 during transactivation...
  14. pmc HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state
    M O Westendorp
    Division of Immunogenetics, German Cancer Research Center, Heidelberg
    EMBO J 14:546-54. 1995
    ..abstract truncated at 250 words)..
  15. pmc The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein
    G Scala
    Department of Biochemistry and Biomedical Technology, Medical School, University Federico II, Naples, Italy
    J Exp Med 179:961-71. 1994
    ..These results suggest that TAT protein may play a role in the pathogenesis of some HIV1-associated diseases by modulating the expression of host cellular genes...
  16. pmc Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells
    M O Westendorp
    Division of Immunogenetics, Tumorimmunology Program, German Cancer Research Center, Heidelberg
    J Virol 68:4177-85. 1994
    ..Furthermore, it might contribute to the hypergammaglobulinemia or, together with other cytokines found to be dysregulated, the T-helper cell dysfunctions observed in AIDS patients...
  17. ncbi Differential effects of I kappa B molecules on Tat-mediated transactivation of HIV-1 LTR
    E Harhaj
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center 17033, USA
    Virology 216:284-7. 1996
    ..While I kappa B alpha, I kappa B beta, and p100 potently inhibit Tat-mediated transactivation, p105 fails to inhibit, but even moderately synergizes, the action of ..
  18. ncbi Iron chelation decreases human immunodeficiency virus-1 Tat potentiated tumor necrosis factor-induced NF-kappa B activation in Jurkat cells
    V A Shatrov
    CJF 94 11 INSERM Cytokines et Immunité Antitumorale, Institut Gustave Roussy, Villejuif, France
    Eur Cytokine Netw 8:37-43. 1997
    ..in the presence of iron ions play a major role in HIV-1 Tat enhancement of TNF-induced NF-kappa B activation and that iron chelation may protect Jurkat T cells, at least in part, against oxidative stress induced by Tat...
  19. pmc Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 A resolution
    P Cramer
    European Molecular Biology Laboratory EMBL, Grenoble Outstation, c o ILL, BP 156, 38042 Grenoble Cedex 9, France
    EMBO J 16:7078-90. 1997
    The crystal structure of human NF-kappaB p52 in its specific complex with the natural kappaB DNA binding site MHC H-2 has been solved at 2.1 A resolution...
  20. ncbi Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-kappaB factors
    M Ott
    The Picower Institute for Medical Research, Manhasset, NY 11030, USA
    J Immunol 160:2872-80. 1998
    ..The effect of Tat101 on CD28REs in the IL-8 promoter and the subsequent up-regulation of IL-8 secretion is likely to contribute to the immune dysregulation observed during HIV-1 infection...
  21. ncbi HIV-1 Tat elongates the G1 phase and indirectly promotes HIV-1 gene expression in cells of glial origin
    M Kundu
    Center for NeuroVirology and NeuroOncology, Allegheny University of the Health Sciences, Philadelphia, Pennsylvania 19102, USA
    J Biol Chem 273:8130-6. 1998
    ..The significance of these findings relates to the current hypothesis that indirect effects of HIV-1 infection of the CNS may contribute to the neurological complications associated with AIDS dementia complex...
  22. pmc Human immunodeficiency virus type 1 tat protein activates transcription factor NF-kappaB through the cellular interferon-inducible, double-stranded RNA-dependent protein kinase, PKR
    F Demarchi
    Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, 34012 Trieste, Italy
    J Virol 73:7080-6. 1999
    ..Activation of NF-kappaB by Tat required integrity of the basic domain of Tat; previous studies have indicated that this domain is necessary for specific Tat-PKR interaction...
  23. ncbi Human immunodeficiency virus type 1 Tat protein stimulates inducible nitric oxide synthase expression and nitric oxide production in microglial cultures
    E Polazzi
    Laboratory of Pathophysiology, Istituto Superiore di Sanita, Rome, Italy
    J Neuropathol Exp Neurol 58:825-31. 1999
    ..Furthermore, the NO-dependent damage may be exacerbated by the presence of IFN-gamma, which is likely to occur in pathological conditions characterized by glial activation and inflammatory cell infiltration...
  24. ncbi Human immunodeficiency virus-1-tat induces matrix metalloproteinase-9 in monocytes through protein tyrosine phosphatase-mediated activation of nuclear transcription factor NF-kappaB
    A Kumar
    Cytokine Research Section, Department of Molecular Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe St Box 143, Houston, TX 77030, USA
    FEBS Lett 462:140-4. 1999
    ..These results suggest that HIV-tat induces MMP-9 in human monocytes through activation of PTPase and NF-kappaB...
  25. ncbi Differential requirement for p56lck in HIV-tat versus TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis
    S K Manna
    Cytokine Research Section, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 164:5156-66. 2000
    ..Overall, our results demonstrate that p56lck plays a critical role in the activation of NF-kappa B, AP-1, JNK, and apoptosis by HIV-tat protein but has minimal or no role in activation of these responses by TNF...
  26. pmc Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway
    A Badou
    Laboratoire d Immuno Virologie EA3038, Universite Paul Sabatier, 31062 Toulouse Cedex, France
    J Virol 74:10551-62. 2000
    ..This production of IL-10 induced by Tat could participate in the progression of HIV infection to AIDS...
  27. ncbi Altered outward-rectifying K(+) current reveals microglial activation induced by HIV-1 Tat protein
    S Visentin
    Laboratory of Pathophysiology, Istituto Superiore di Sanita, V le Regina Elena 299, 00161 Rome, Italy
    Glia 33:181-90. 2001
    ..We propose that such effect of Tat could be part of the process of microglial activation known to take place in the brain of persons with neuro-AIDS...
  28. ncbi Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures
    M Patrizio
    Neurobiology Section, Laboratory of Pathophysiology, Istituto Superiore di Sanita, Rome, Italy
    J Neurochem 77:399-407. 2001
    ....
  29. ncbi Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex
    Tomoshige Kino
    Pediatric and Reproductive Endocrinology Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:2396-405. 2002
    ..Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 coactivators and the P-TEFb complex...
  30. pmc Human immunodeficiency virus type 1 (HIV-1) tat induces nitric-oxide synthase in human astroglia
    Xiaojuan Liu
    Department of Oral Biology, University of Nebraska Medical Center, Lincoln, Nebraska 68583, USA
    J Biol Chem 277:39312-9. 2002
    ..This study illustrates a novel role for HIV-1 tat in inducing the expression of iNOS in human astrocytes that may participate in the pathogenesis of HIV-associated dementia...
  31. ncbi B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50
    A Neri
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Cell 67:1075-87. 1991
    ..The lyt-10 gene defines a new subfamily (rel/poly-G/ankyrin) of NF-kappa B-rel transcription factors with potential for oncogenic activation in human cancer...
  32. ncbi Heterogeneous chromosomal aberrations generate 3' truncations of the NFKB2/lyt-10 gene in lymphoid malignancies
    A Migliazza
    Laboratorio di Ematologia Sperimentale e Genetica Molecolare, Istituto di Scienze Mediche, Universita di Milano, Ospedale Maggiore IRCCS, Italy
    Blood 84:3850-60. 1994
    The NFKB2(lyt-10) gene codes for a protein that is a member of the NK-kappa B/rel family of transcription factors containing a DNA-binding rel domain and a carboxy-terminal ankyrin-like domain...
  33. ncbi Rearrangement and altered expression of the NFKB-2 gene in human cutaneous T-lymphoma cells
    S Thakur
    Center for Advanced Biotechnology and Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry, New Jersey, Piscataway 08854
    Oncogene 9:2335-44. 1994
    ..DNA sequence predicted the presence of a truncated 80 kD NFKB-2 precursor protein (p80HT), instead of the normal p100 protein. No wild-type allele was identified...
  34. ncbi Structural alterations of the NF-kappa B transcription factor lyt-10 in lymphoid malignancies
    N S Fracchiolla
    Laboratorio di Ematologia Sperimentale e Genetica Molecolare, Istituto di Scienze Mediche, Milan, Italy
    Oncogene 8:2839-45. 1993
    ..This gene, called lyt-10 (NFKB2/p52), is a member of the NF-kappa B family of transcription factors and displays a high degree of homology with ..
  35. pmc Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes
    K Conant
    Laboratory of Molecular Medicine and Neuroscience, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    J Virol 70:1384-9. 1996
    ..These effects include Tat's ability to upregulate the synthesis of specific cytokines and to act as a growth factor...
  36. ncbi The NF-kappa B and I kappa B proteins: new discoveries and insights
    A S Baldwin
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599, USA
    Annu Rev Immunol 14:649-83. 1996
    ....
  37. ncbi The involvement of the candidate proto-oncogene NFKB2/lyt-10 in lymphoid malignancies
    A Neri
    Laboratorio di Ematologia Sperimentale e Genetica Molecolare, Universita di Milano, Ospedale Maggiore IRCCS, Milan, Italy
    Leuk Lymphoma 23:43-8. 1996
    ..Two subunits, NF-kappa B1p50 and NF-kappa B2p52, coded respectively by the NFKB1 and NFKB2 genes, may only have DNA binding activity...
  38. ncbi New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases
    F Chen
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA lfd32cdc gov
    Clin Chem 45:7-17. 1999
    ..Therefore, development of modulatory strategies targeting this transcription factor may provide a novel therapeutic tool for the treatment or prevention of various diseases...
  39. ncbi Transcriptional regulatory effects of lymphoma-associated NFKB2/lyt10 protooncogenes
    K E Kim
    Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry Robert Wood Johnson Medical School, Piscataway, New Jersey, NJ 08854, USA
    Oncogene 19:1334-45. 2000
    C-terminal truncations of the NFKB2 p100 gene product have been observed in a number of cases of human cutaneous T cell lymphomas, as well as human B-cell lymphomas and myelomas...
  40. ncbi NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100
    G Xiao
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Mol Cell 7:401-9. 2001
    Processing of the nf(kappa)b2 gene product p100 to generate p52 is an important step in NF-kappaB regulation...
  41. ncbi NF-kappa B2 p100 is a pro-apoptotic protein with anti-oncogenic function
    Yongqing Wang
    Department of Biochemistry and Molecular Biology, Medical College of Ohio, 3035 Arlington Avenue, Toledo, OH 43614, USA
    Nat Cell Biol 4:888-93. 2002
    ..The only NF-kappa B family member known to be mutated in human cancer is NF-kappa B2 p100 (ref. 2), a factor with I kappa B activity...
  42. ncbi U50,488 inhibits HIV-1 Tat-induced monocyte chemoattractant protein-1 (CCL2) production by human astrocytes
    Wen S Sheng
    Neuroimmunology Laboratory, Minneapolis Medical Research Foundation, 914 South 8th Street, Minneapolis, MN 55404, USA
    Biochem Pharmacol 65:9-14. 2003
    ..These findings suggest that KOR ligands could have an anti-inflammatory effect in the CNS and thereby be beneficial in the treatment of HIV-1-associated brain disease...
  43. pmc p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1
    Sonia Rocha
    School of Life Sciences, Division of Gene Expression and Regulation, University of Dundee, Scotland, United Kingdom
    Mol Cell Biol 23:4713-27. 2003
    ..was dependent on the proximal NF-kappaB binding site of the cyclin D1 promoter, which has been shown to bind the p52 NF-kappaB subunit...
  44. ncbi Identification and characterization of p100HB, a new mutant form of p100/NF-kappa B2
    Emmanuel Derudder
    Oncogenèse, Differenciation et Transduction du Signal, UPR 9079 du CNRS, Institut Andre Lwoff, 7, rue Guy Moquet, 94801 Villejuif, France
    Biochem Biophys Res Commun 308:744-9. 2003
    b>P100, which is encoded by NF-kappa B2, inhibits Rel dimers. It can also be processed into p52, one of the DNA binding sub-units of NF-kappa B/Rel factors...
  45. ncbi Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100
    Guoliang Qing
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, 604 Allison Rd, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:9765-8. 2005
    Processing of NF-kappaB2 precursor protein p100 to generate p52 is tightly controlled, which is important for proper function of NF-kappaB...
  46. ncbi Stabilization of basally translated NF-kappaB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100
    Guoliang Qing
    Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:40578-82. 2005
    The non-canonical pathway based on processing of NF-kappaB2 precursor protein p100 to generate p52 plays a critical role in controlling B cell function and lymphoid organogenesis...
  47. ncbi beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870
    Chunyang Liang
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, P O Box 850, Hershey, Pennsylvania 17033, USA
    Cell Signal 18:1309-17. 2006
    Processing of the NF-kappaB2 precursor protein p100 is a major step in noncanonical NF-kappaB signaling. This signaling step requires the NF-kappaB inducing kinase (NIK) and its downstream kinase, IkappaB kinase alpha (IKKalpha)...
  48. pmc Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation
    Nagalakshmi Nadiminty
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Proc Natl Acad Sci U S A 103:7264-9. 2006
    Activation of the noncanonical NF-kappaB signaling pathway involved in the proteolytic processing of NF-kappaB p100 to p52 is tightly regulated, and overproduction of p52 leads to lymphocyte hyperplasia and transformation...
  49. pmc The role of NF-{kappa}B-1 and NF-{kappa}B-2-mediated resistance to apoptosis in lymphomas
    Leon Bernal-Mizrachi
    Division of Molecular Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:9220-5. 2006
    ..These findings demonstrate an important role of both NF-kappaB pathways in mediating resistance to apoptosis and distinctive antiapoptotic downstream target gene profiles responsible for this effect...
  50. pmc Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit
    Katie Schumm
    College of Life Sciences, Division of Gene Regulation and Expression, University of Dundee, Dundee, UK
    EMBO J 25:4820-32. 2006
    The p52/p100 nuclear factor kappa B (NF-kappaB) subunit (NF-kappaB2) is aberrantly expressed in many tumour types and has been implicated as a regulator of cell proliferation...
  51. pmc A fourth IkappaB protein within the NF-kappaB signaling module
    Soumen Basak
    Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 128:369-81. 2007
    ..We report here the characterization of a fourth inhibitor, nfkappab2/p100, that forms two distinct inhibitory complexes with RelA, one of which mediates developmental NF-kappaB activation...
  52. pmc A cell cycle regulatory network controlling NF-kappaB subunit activity and function
    Benjamin Barré
    Division of Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
    EMBO J 26:4841-55. 2007
    ..Akt is inactivated, while Chk1 phosphorylates RelA and associates with IKKalpha, inhibiting the processing of the p100 (NF-kappaB2) subunit, which also plays a critical role in the regulation of these genes...
  53. doi Regulation and function of NF-kappaB transcription factors in the immune system
    Sivakumar Vallabhapurapu
    Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, Cancer Center, University of California, San Diego, California 93093, USA
    Annu Rev Immunol 27:693-733. 2009
    ..including RelA, c-Rel, RelB, NF-kappaB1 (p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), plays a central role in the immune system by regulating several processes ranging from the development and ..
  54. pmc Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma
    Luca Busino
    NYU Cancer Institute, New York University School of Medicine, 522 First Avenue, SRB 1107, New York, New York 10016, USA
    Nat Cell Biol 14:375-85. 2012
    ..Using differential purifications and mass spectrometry, we identified p100, an inhibitor of NF-κB signalling, as an interactor of Fbxw7α...
  55. pmc Transcriptional regulation of NF-kappa B2: evidence for kappa B-mediated positive and negative autoregulation
    S Liptay
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109 0650
    Mol Cell Biol 14:7695-703. 1994
    ..In contrast to other family members, we find that kappa B elements in the NFKB2 promoter can also mediate transcriptional repression in the absence of NF-kappa B...
  56. pmc Reciprocal modulatory interaction between human immunodeficiency virus type 1 Tat and transcription factor NFAT1
    F Macian
    Department of Pathology, Harvard Medical School, and Center for Blood Research, Boston, Massachusetts 02115, USA
    Mol Cell Biol 19:3645-53. 1999
    ..We discuss the potentially opposing roles of NFAT1 and another family member, NFAT2, in regulating gene transcription of HIV-1 and endogenous cytokine genes...
  57. pmc The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell line U-87 MG: role of SP-1, AP-1, and NF-kappaB consensus sites
    S P Lim
    Institute of Molecular and Cell Biology, Singapore 117609, Singapore
    J Virol 74:1632-40. 2000
    ..We postulate that a Tat-mediated increase in SP1 binding activities augments the binding of AP1 and NF-kappaB, leading to synergistic activation of the MCP-1 promoter...
  58. ncbi HIV type 1 Tat inhibits tumor necrosis factor alpha-induced repression of tumor necrosis factor receptor p55 and amplifies tumor necrosis factor alpha activity in stably tat-transfected HeLa Cells
    C Chiao
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health and Science, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    AIDS Res Hum Retroviruses 17:1125-32. 2001
    ..Our results indicate that HIV-1 Tat may inhibit TNF-alpha-induced repression of TNFR p55 and thereby amplify TNF-alpha activity in these stably transfected cells...
  59. pmc Chronic human immunodeficiency virus type 1 infection stimulates distinct NF-kappa B/rel DNA binding activities in myelomonoblastic cells
    A Roulston
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Virol 67:5235-46. 1993
    ..sequence but do not cross-react with NF-kappa B subunit-specific antisera directed against NFKB1 (p105 or p50), NFKB2 (p100 or p52), RelA (p65), or c-rel...
  60. ncbi Nuclear factor-kappaB signature of inflammatory breast cancer by cDNA microarray validated by quantitative real-time reverse transcription-PCR, immunohistochemistry, and nuclear factor-kappaB DNA-binding
    Steven J Van Laere
    Translational Cancer Research Group Laboratory of Pathology, University of Antwerp and Oncology Center, General Hospital Sint Augustinus, Wilrijk, Belgium
    Clin Cancer Res 12:3249-56. 2006
    ..This led to the hypothesis that NF-kappaB contributes to the phenotype of IBC. The aim of the present study was to further investigate the role of NF-kappaB in IBC...
  61. ncbi Normal structure of NFKB2, C-REL and BCL-3 gene loci in lymphoproliferative and myeloproliferative disorders
    G Munzert
    Abteilung Innere Medizin III, Universitat Ulm, Germany
    Leuk Lymphoma 38:395-400. 2000
    ..Our results demonstrate that structural alterations of NFkappaB2, c-rel and bcl-3 genes at the Southern Blotting level are rare events that do not contribute to lymphoid or myeloid transformation in the majority of NHL or cMPS patients...
  62. pmc Classical and/or alternative NF-kappaB pathway activation in multiple myeloma
    Yulia N Demchenko
    Genetics Branch, National Cancer Institute, Bethesda, MD, USA
    Blood 115:3541-52. 2010
    ..First, only one mutation (NFKB2) selectively activates the alternative pathway, whereas several mutations (CYLD, NFKB1, and TACI) selectively ..
  63. pmc Cytomegalovirus-induced embryopathology: mouse submandibular salivary gland epithelial-mesenchymal ontogeny as a model
    Michael Melnick
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, CA 90089 0641, USA
    BMC Dev Biol 6:42. 2006
    ..In this study, we chose to model the vulnerability by investigating the cell and molecular pathogenesis of CMV infected mouse embryonic submandibular salivary glands (SMGs)...
  64. ncbi Trophoblast giant cells express NF-kappa B2 during early mouse development
    A Muggia
    Dipartimento di Genetica e Biologia dei Microrganismi dell Università di Milano, Italy
    Dev Genet 25:23-30. 1999
    ..the NF-kappa B family could play a role in early mammalian development, we have analyzed the expression of nfkb1, nfkb2, c-Rel, RelA, RelB, and bcl-3 from 6.5- to 10.5-day mouse embryo implantation sites...
  65. pmc Combined genome-wide expression profiling and targeted RNA interference in primary mouse macrophages reveals perturbation of transcriptional networks associated with interferon signalling
    Paul Lacaze
    Division of Pathway Medicine, The University of Edinburgh, The Chancellor s Building, College of Medicine, Edinburgh, UK
    BMC Genomics 10:372. 2009
    ..Genome-wide changes in transcript abundance caused by siRNA activity were measured using exon-level microarrays in the presence or absence of IFNgamma...
  66. ncbi Chromosomal localization of the genes encoding the p50/p105 subunits of NF-kappa B (NFKB2) and the I kappa B/MAD-3 (NFKBI) inhibitor of NF-kappa B to 4q24 and 14q13, respectively
    M M Le Beau
    Section of Hematology Oncology, University of Chicago, Illinois 60637
    Genomics 14:529-31. 1992
    ..to determine the chromosomal organization of members of the REL/NFKB family, as well as their inhibitors, we localized the NFKBp50/p105 (NFKB2) and I kappa B/MAD-3 (NFKBI) genes to human chromosome bands 4q24 and 14q13, respectively.
  67. ncbi The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-kappa B and I kappa B-gamma: implications for NF-kappa B-mediated signal transduction
    E Heron
    Vitamins and Fine Chemicals Division, F Hoffmann La Roche Limited, Basel, Switzerland
    Genomics 30:493-505. 1995
    ..NFKB1 spans 156 kb and has 24 exons with introns varying between 40,000 and 323 bp in length. Although NFKB2, which encodes p100 and p52, also has 24 exons and has a comparable exon-intron structure, it is 20 times shorter (..
  68. ncbi Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2
    V Iotsova
    Department of Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000, USA
    Nat Med 3:1285-9. 1997
    The nfkb1 and nfkb2 genes encode closely related products regulating immune and inflammatory responses. Their role during development and differentiation remains unclear...
  69. pmc Identification of cis and trans-acting transcriptional regulators in chondroinduced fibroblasts from the pre-phenotypic gene expression profile
    Karen E Yates
    Department of Orthopedic Surgery, Orthopedic Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Gene 377:77-87. 2006
    ..of mRNAs showed increased gene expression of both types of transcription factors in chondroinduced hDFs, including NFKB2 (290% of control), RELA (160%), and GATA2 (190%)...
  70. doi Comparative genome profiling across subtypes of low-grade B-cell lymphoma identifies type-specific and common aberrations that target genes with a role in B-cell neoplasia
    Bibiana I Ferreira
    Molecular Cytogenetics Group, Centro Nacional Investigaciones Oncologicas CNIO, Melchor Fernandez Almagro, 3, 28029 Madrid, Spain
    Haematologica 93:670-9. 2008
    ..Our objective was to search for genomic features that allow a better molecular identification of the different types of lymphoma studied...
  71. doi Increased levels of NOTCH1, NF-kappaB, and other interconnected transcription factors characterize primitive sets of hematopoietic stem cells
    Rodrigo Alexandre Panepucci
    Department of Clinical Medicine of the Faculty of Medicine of Ribeirao Preto USP, Center for Cell Therapy and Regional Blood Center, Araraquara, Sao Paulo, Brazil
    Stem Cells Dev 19:321-32. 2010
    ..to primitive hematopoiesis and self-renewal, such as RUNX1, GATA3, USF1, TAL1, HOXA9, HOXB4, NOTCH1, RELB, and NFKB2 were evaluated by real-time PCR and were all significantly positively correlated...
  72. doi Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells
    Simone Reuter
    Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Hopital Kirchberg, Luxembourg, Luxembourg
    Ann N Y Acad Sci 1171:436-47. 2009
    ..CARD4, CCL2, CD40, CSF2, F2R, ICAM1, IKBKB, IKBKE, IL1A, IL1B, IL6, IL8, IRAK2, MALT1, MAP3K1, MYD88, NFKB1, NFKB2, NFKBIA, PPM1A, RAF1, RELB, STAT1, TLR3, TNF, TNFalphaIP3, TNFSF10, and TICAM1), whereas 10 mRNAs were induced (..
  73. ncbi Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes
    Daisuke Matsubara
    Department of Human Pathology, School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer Sci 96:844-57. 2005
    ..progression: S100A2 induced RUNX3 and REPRIMO; S100A4 induced EZRIN, RUNX1 and WISP1; S100A2 repressed EGFR, NFKB2 and RELA2; and S100A4 repressed ANXA10 and IL1RN...
  74. ncbi Transcriptional profiling of the nuclear factor-kappaB pathway identifies a subgroup of primary lymphoma of the central nervous system with low BCL10 expression
    Cornelius Courts
    Department of Neuropathology, University Hospital of Cologne, Cologne, Germany
    J Neuropathol Exp Neurol 66:230-7. 2007
    ..PCNSLs, whereas that of BAX, BCLXL, BCL2, MALT1, CARD9, CARD10, CARD11, CARD14, CCND2, cFLIP, RELA, RELB, NFKB1, NFKB2, and IRF4 was higher...
  75. pmc Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma
    Christina M Annunziata
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Cell 12:115-30. 2007
    ..often associated with genetic or epigenetic alteration of NIK, TRAF3, CYLD, BIRC2/BIRC3, CD40, NFKB1, or NFKB2. These data demonstrate that addiction to the NF-kappaB pathway is frequent in myeloma and suggest that IKKbeta ..
  76. pmc Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma
    Jonathan J Keats
    Comprehensive Cancer Center, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Cancer Cell 12:131-44. 2007
    ..report mutations in ten genes causing the inactivation of TRAF2, TRAF3, CYLD, cIAP1/cIAP2 and activation of NFKB1, NFKB2, CD40, LTBR, TACI, and NIK that result primarily in constitutive activation of the noncanonical NF-kappaB pathway, ..
  77. pmc NF-kappaB2 (p100) limits TNF-alpha-induced osteoclastogenesis
    Sakae Tanaka
    Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Clin Invest 119:2879-81. 2009
    ..of p100 in osteoclast precursors, and TNF-alpha-induced osteoclast formation was markedly increased in Nfkb2-/- mice...
  78. ncbi Constitutive expression of lymphoma-associated NFKB-2/Lyt-10 proteins is tumorigenic in murine fibroblasts
    P Ciana
    Istituto di Scienze Mediche, Universita di Milano, Ospedale Maggiore IRCCS Milan, Italy
    Oncogene 14:1805-10. 1997
    ..Such mutant NFKB-2 proteins have lost the ability to repress transcription that is typical of NFKB-2 subunit p52, and function as constitutive transcriptional activators...
  79. pmc Refined physical map of the human PAX2/HOX11/NFKB2 cancer gene region at 10q24 and relocalization of the HPV6AI1 viral integration site to 14q13.3-q21.1
    Sheryl M Gough
    Cancer Genetics Research Group, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    BMC Genomics 4:9. 2003
    ....
  80. doi Role of NFKB2 on the early myeloid differentiation of CD34+ hematopoietic stem/progenitor cells
    Greice Andreotti De Molfetta
    Center for Cell Therapy, Blood Center of the University of Sao Paulo, Rua Tenente Catao Roxo 2501, 14051 140 Ribeirão Preto SP, Brazil
    Differentiation 80:195-203. 2010
    ..Among those we found transcripts for NFKB2, RELB, IL1B, LTB, LTBR, TNFRSF4, TGFB1, and IKBKA. Also, the inhibitor NFKBIA (IKBA) was more expressed at 12h...
  81. ncbi Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization
    S Mathew
    Laboratory of Cancer Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    Oncogene 8:191-3. 1993
    ..The map position of lyt-10, inferred from its isolation from a t(10;14)(q24;q32) translocation, has been confirmed. NF-kappa Bp65 has now been mapped to 11q13, a site of frequent involvement in aberration in multiple tumor types...
  82. pmc Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2
    H Ishikawa
    The Department of Oncology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000, USA
    J Exp Med 186:999-1014. 1997
    The nfkb2 gene encodes the p100 precursor which produces the p52 protein after proteolytic cleavage of its COOH-terminal domain...
  83. doi Melatonin improves inflammation processes in liver of senescence-accelerated prone male mice (SAMP8)
    Sara Cuesta
    Department Physiology, Medical School, University Complutense of Madrid, Avenida Complutense s n, Madrid, Spain
    Exp Gerontol 45:950-6. 2010
    ..The parameters studied have been the mRNA expression of TNF-α, iNOS, IL-1β, HO-1, HO-2, MCP1, NFkB1, NFkB2, NFkB protein or NKAP and IL-10...
  84. ncbi Integration of human papillomavirus type 6a DNA in a tonsillar carcinoma: chromosomal localization and nucleotide sequence of the genomic target region
    T Kahn
    Deutsches Krebsforschungszentrum, Angewandte Tumorvirologie, Heidelberg, Germany
    Cancer Res 54:1305-12. 1994
    ..In addition it contains the site of breakpoints affecting protooncogenes Hox11 and Lyt10. Other genes related to cell division and DNA repair have also been mapped to this chromosomal band...
  85. ncbi Temporal and subunit-specific modulations of the Rel/NF-kappaB transcription factors through CD28 costimulation
    B Kahn-Perles
    Unité de Cancérologie Expérimentale, U119 INSERM, 27 Boulevard Lei Roure, 13009 Marseille, France
    J Biol Chem 272:21774-83. 1997
    ..stimulation specifically induces, at maximal T cell proliferation phase, sustained nuclear overexpression of NFKB2 p52 and c-Rel subunits which might rely on long-lasting processing of p100 precursor for p52 and increased ..
  86. pmc Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein
    Soizic Bourteele
    Friedrich Loeffler Institut, Federal Research Institute for Animals Health, Institute of Immunology Tübingen, Germany
    Cell Microbiol 9:2202-17. 2007
    ..Additionally, we investigated the role of NF-kappaB after prion infection of Nfkb1(-/-), Nfkb2(-/-) and Bcl3(-/-) mice and central nervous system-specific p65-deleted mice revealing an accelerated prion ..
  87. pmc Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis
    Oscar L Volger
    Department of Medical Biochemistry, Room K1 114, Academic Medical Center, University of Amsterdam, Meibergdreef 15, NL 1105 AZ, Amsterdam, The Netherlands
    Am J Pathol 171:326-37. 2007
    ..endothelial protein expression between early (fractalkine/CX3CL1, IP10/CCL10, TBX18) or advanced (BAX, NFKB2) stages of atherosclerosis and versus their plaque-free controls...
  88. ncbi Molecular characteristics of liver metastases from uveal melanoma
    Tal Meir
    Department of Ophthalmology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Invest Ophthalmol Vis Sci 48:4890-6. 2007
    ..This study was conducted to obtain insight into the molecular pathways that underlie the development of UM metastasis and thus to identify potential novel therapeutic pathways for this disease...
  89. pmc NF-kappa B genes have a major role in inflammatory breast cancer
    Florence Lerebours
    Centre Rene Huguenin, FNCLCC, 35 rue Dailly, 92210, St Cloud, France
    BMC Cancer 8:41. 2008
    ..Given the role of NF-kappaB-related genes in cell proliferation, invasiveness, angiogenesis and inflammation, we postulated that they might be deregulated in IBC...
  90. ncbi The genome-wide expression profile of Nelumbinis semen on lipopolysaccharide-stimulated BV-2 microglial cells
    Sung Hwa Sohn
    Department of Physiology, College of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea
    Biol Pharm Bull 32:1012-20. 2009
    ..that mitogen activated protein kinase (MAPK) signaling pathway-related genes such as Fgfr3, Fgf12, Rasal2, Nfkb2, Map2k5, Mapk1, Map3k7, and NFatc2 were down-regulated in LPS activated BV-2 cells by pretreatment with NS...
  91. pmc Disruption of SM22 promotes inflammation after artery injury via nuclear factor kappaB activation
    Jianbin Shen
    Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA
    Circ Res 106:1351-62. 2010
    ..Abolishing SM22 in apolipoprotein E knockout mice accelerates atherogenesis. However, it is unclear whether SM22 disruption independently promotes arterial inflammation...
  92. ncbi Two novel functions associated with the Rel oncoproteins: DNA replication and cell-specific transcriptional activation
    H Ishikawa
    Department of Viral Oncology, Kyoto University, Japan
    Oncogene 8:2889-96. 1993
    ..This activity is common to v-Rel, c-Rel, p52 (p49/lyt10), RelA (p65) and the p50 subunit of NF-kappa B...
  93. ncbi Gene and protein expression profiling of human cerebral endothelial cells activated with tumor necrosis factor-alpha
    Bo Franzén
    Gene and Protein Technology, Molecular Sciences, Local Discovery Research Area, CNS and Pain Control, AstraZeneca R and D, Sodertalje, Sweden
    Brain Res Mol Brain Res 115:130-46. 2003
    ..However, nuclear factors NFkB1 and NFkB2, plasminogen activator inhibitor 1 and cofilin 1 are examples of cerebral specific responses...
  94. doi Comparison of expression profiles induced by dust mite in airway epithelia reveals a common pathway
    A B Vroling
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Allergy 63:461-7. 2008
    ..Airway epithelial cells have shown to be active participants in the defense against pathogens by producing signaling and other regulatory molecules in response to the encounter...
  95. ncbi Isolation of a cDNA encoding the chicken p50B/p97 (Lyt-10) transcription factor
    T Ikeda
    National Institute of Animal Health, Ibaraki, Japan
    Gene 138:193-6. 1994
    ..Expression of this gene is highest in the chicken spleen...
  96. ncbi NF-kappa B precursor p100 inhibits nuclear translocation and DNA binding of NF-kappa B/rel-factors
    M Naumann
    Max Planck Institut fur Molekulare Genetik, Otto Warburg Laboratorium, Berlin Dahlem
    Oncogene 8:2275-81. 1993
    The NF-kappa B precursor p100 (lyt-10, p97, p98) generates after proteolytic processing a 52 kDa subunit, which can bind to kappa B-motifs...
  97. pmc NF-kappa B p100 (Lyt-10) is a component of H2TF1 and can function as an I kappa B-like molecule
    R I Scheinman
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill 27599
    Mol Cell Biol 13:6089-101. 1993
    ..We show here that NF-kappa B p100 is a component of the previously identified DNA-binding activity H2TF1. In addition, we show that p100 is localized in the cytoplasm in HeLa cells, where it is associated with c-Rel, ..
  98. pmc Transdominant mutants of I kappa B alpha block Tat-tumor necrosis factor synergistic activation of human immunodeficiency virus type 1 gene expression and virus multiplication
    P Beauparlant
    Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    J Virol 70:5777-85. 1996
    ..These experiments suggest a strategy that may contribute to inhibition of HIV-1 gene expression by interfering with the NF-kappa B/Rel signaling pathway...
  99. ncbi Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines
    Naohito Saito
    Department of Molecular Virology, Graduate School of Medicine, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8519, Japan
    J Biol Chem 278:46565-75. 2003
    ..One originates in CTAR2, operates through the canonical NEMO-dependent pathway, and induces NFKB2 p100 production; the second signal originates in CTAR1, utilizes NIK and IKK1, and induces the processing of p100...
  100. ncbi Epstein-Barr virus-encoded latent infection membrane protein 1 regulates the processing of p100 NF-kappaB2 to p52 via an IKKgamma/NEMO-independent signalling pathway
    Aristides G Eliopoulos
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham Medical School, Birmingham B15 2TA, UK
    Oncogene 22:7557-69. 2003
    ..In this study, we show that LMP1 also promotes the proteasome-mediated proteolysis of p100 NF-kappaB2 resulting in the generation of active p52, which translocates to the nucleus in complex with the p65 and ..
  101. ncbi Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase
    Ruthie E Amir
    Department of Biochemistry and the Rappaport Family Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Oncogene 23:2540-7. 2004
    Processing of the NF-kappa B2 precursor p100 to the mature p52 subunit is regulated via a unique pathway...

Research Grants10

  1. CHRISTOPHE P NICOT; Fiscal Year: 2014
    ..The Nfkb2 gene is frequently involved in chromosomal translocations associated with human cutaneous T-cell lymphomas...
  2. Chemoresistance and Motility: Role of Mutant p53 and NF-kB2 in Cancer
    Sumitra Deb; Fiscal Year: 2011
    ..Results obtained from this study should lead to identification of a subset of lung tumors co- expressing NFkB2 and mutant p53 that could be targeted by inhibitors of NF-kB pathway to prevent tumor progression.
  3. Specificity of the Ubiquitin System in Lymphoid Malignancies
    Luca Busino; Fiscal Year: 2013
    ..myeloma cells, Fbxw7 functions as a pro-survival gene by promoting the degradation of the NF-?B inhibitor, Nfkb2 (p100)...
  4. Molecular Basis of iNKT Cell Ontogeny and Function
    Sebastian Joyce; Fiscal Year: 2010
    ..This function of NF-kB is largely dependent on NFkB1 (cell autonomous), to a lesser extent on NFkB2, and RelB (cell extrinsic) activities...
  5. Molecular Mechanisms Mediating NF-kB2/p100 Processing
    Shao Cong Sun; Fiscal Year: 2007
    Signal-induced processing of the nfkb2 gene product, pl00, is a critical mechanism of NF-kB regulation. The full-length pl00 functions as a potent inhibitor of NF-kB, sequestering various NF-kB members in the cytoplasm...
  6. Cytokines in Health and Disease: 15th Annual Meeting of the International Cytokin
    STEPHEN SMALE; Fiscal Year: 2008
    ..abstract_text> ..
  7. MOLECULAR TARGETS OF NITRIC OXIDE IN CARDIAC TRANSPLANTS
    GALEN PIEPER; Fiscal Year: 2004
    ..These studies will provide a novel mechanism to explain the pathogenesis of dyskinesis and graft failure during cardiac transplant rejection. ..
  8. TRANSCRIPTIONAL REGULATORS OF CHONDROINDUCTION BY DBP
    Karen Yates; Fiscal Year: 2004
    ..We will determine which DBP-regulated transcription factors are necessary and/or sufficient for postnatal chondrogenesis. This proposed work would have a high impact of design of strategies for repair and/or regeneration of cartilage. ..
  9. WNT PROTEINS IN ADULT, AGED AND OSTEOARTHRITIC CARTILAGE
    Karen Yates; Fiscal Year: 2005
    ..This work will also provide a solid foundation for future research on Wnts in cartilage biology. ..
  10. iNOS Posttranslational Regulation in Cardiac Rejection
    GALEN PIEPER; Fiscal Year: 2009
    ..A better understanding of this molecular process may lead to better strategies to prevent injury cardiac cells in these patients. ..