NFIA

Summary

Gene Symbol: NFIA
Description: nuclear factor I/A
Alias: CTF, NF-I/A, NF1-A, NFI-A, NFI-L, CCAAT-box-binding transcription factor, TGGCA-binding protein, nuclear factor 1 A-type
Species: human

Top Publications

  1. ncbi Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A
    Yun Lu Lin
    Department of Life Science, National Dong Hwa University, Hualien 97401, Taiwan
    Biochem Biophys Res Commun 350:430-6. 2006
  2. ncbi Emx and Nfi genes regulate cortical development and axon guidance in the telencephalon
    Michael Piper
    The University of Queensland, Queensland Brain Institute and The School of Biomedical Sciences, Brisbane 4074, Australia
    Novartis Found Symp 288:230-242; discussion 242-5, 276-81. 2007
  3. pmc Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum
    L das Neves
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA
    Proc Natl Acad Sci U S A 96:11946-51. 1999
  4. doi Expression of nuclear factor one A and -B in the olfactory bulb
    Celine Plachez
    The University of Maryland, Baltimore, School of Medicine, Baltimore, Maryland 21201 1559, USA
    J Comp Neurol 520:3135-49. 2012
  5. ncbi Comparative chromosomal studies of E. caballus (ECA) and E. przewalskii (EPR) in a female F1 hybrid
    E Ahrens
    Department of Animal Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Anim Breed Genet 122:97-102. 2005
  6. pmc Evidence that nuclear factor IA inhibits repair after white matter injury
    Stephen P J Fancy
    Departments of Pediatrics and Neurosurgery, Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine and Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
    Ann Neurol 72:224-33. 2012
  7. ncbi MicroRNAs function on a new level
    Ryan M O'Connell
    University of Utah
    Blood 119:3875-6. 2012
  8. pmc Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis
    Peng Kang
    Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 74:79-94. 2012
  9. ncbi Imaging, anatomical, and molecular analysis of callosal formation in the developing human fetal brain
    Tianbo Ren
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:191-204. 2006
  10. doi Adiponectin, adiponectin receptors, and epigenetic regulation of adipogenesis
    T Kadowaki
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cold Spring Harb Symp Quant Biol 76:257-65. 2011

Research Grants

  1. Transcriptional regulation of pontine development
    E Litwack; Fiscal Year: 2009
  2. Role of NFI in type II Cell Function
    CINDY BACHURSKI; Fiscal Year: 2006
  3. Fate of Aggrecan-Expressing Progenitors in Gliogenesis
    Miriam Domowicz; Fiscal Year: 2004
  4. Mapping Gene Networks in Colon Cancer
    Norman H Lee; Fiscal Year: 2010

Scientific Experts

  • T Kadowaki
  • Jean Spence
  • Fady M Mikhail
  • Udo Koehler
  • Carlos A Scrideli
  • Christine E Campbell
  • Norman Lee
  • Miriam Domowicz
  • Yong W Wong
  • Pontus C Holm
  • F B Berry
  • Shigehiro Osada
  • Chih Ping Chen
  • Richard M Gronostajski
  • Linda J Richards
  • Michael Piper
  • Celine Plachez
  • Wei Wang
  • E Litwack
  • CINDY BACHURSKI
  • Benjamin Deneen
  • E David Litwack
  • Randal X Moldrich
  • Sharon Mason
  • George Steele-Perkins
  • Charlotta Lindwall
  • Tianbo Ren
  • Daniel L Kilpatrick
  • Jeannine Lacroix
  • Eleonora Porcu
  • Marylyn D Ritchie
  • Lachlan Harris
  • Heon Jeong Lee
  • Tiziana Franceschetti
  • Laura A Genovesi
  • Kathryn M Tsang
  • Eric J Benner
  • Kathleen Cato
  • Yee Hsieh Evelyn Heng
  • Chunyu Liu
  • Andrew A Hicks
  • Stephen P J Fancy
  • Tiffany A Greenwood
  • Ryan M O'Connell
  • Yongming Huang
  • John R Kelsoe
  • Peng Kang
  • Meggie Finley
  • Stacey M Glasgow
  • Peter P Pramstaller
  • Albert Gründer
  • Erin N Smith
  • Wenhua Wei
  • Hironori Waki
  • Yu Chih Hsu
  • Lakshmi Subramanian
  • Timothy L Bailey
  • Anindita Sarkar
  • Shubha Tole
  • Kenneth G Butz
  • Sika Zheng
  • Hae Ri Song
  • Linda Marie Starnes
  • LAURA A PEREZ-CASELLAS
  • Asli Kumbasar
  • Miranda Brun
  • Laura J Scott
  • Guy Barry
  • James E Crandall
  • Joyce E Royland
  • Jiangyang Zhang
  • Susumu Mori
  • Cindy J Bachurski
  • Irene Bozzoni
  • Weining Lu
  • R M Gronostajski
  • Katrin Driller
  • Alessandro Fatica
  • Maria Laura De Marchis
  • Clara Nervi
  • Yun Lu Lin
  • Stephen L Kinsman
  • E Ahrens
  • Hua Xu
  • Francesco Fazi
  • Albrecht E Sippel
  • P Christoph Champ
  • Tianzhi Shu
  • Sebastian Bender
  • Dominik Sturm

Detail Information

Publications67

  1. ncbi Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A
    Yun Lu Lin
    Department of Life Science, National Dong Hwa University, Hualien 97401, Taiwan
    Biochem Biophys Res Commun 350:430-6. 2006
    ..In conclusion, our results indicated that NF1-A transcription factor plays an important role in the transcriptional activation of the TR2 gene expression via the PACE-C in the minimal promoter region...
  2. ncbi Emx and Nfi genes regulate cortical development and axon guidance in the telencephalon
    Michael Piper
    The University of Queensland, Queensland Brain Institute and The School of Biomedical Sciences, Brisbane 4074, Australia
    Novartis Found Symp 288:230-242; discussion 242-5, 276-81. 2007
    ..The Nfi gene family is made up of four members, Nfia, Nfib, Nfic and Nfix...
  3. pmc Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum
    L das Neves
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA
    Proc Natl Acad Sci U S A 96:11946-51. 1999
    ..We showed previously that the four murine NFI genes (Nfia, Nfib, Nfic, and Nfix) are expressed in unique but overlapping patterns during mouse development and in adult ..
  4. doi Expression of nuclear factor one A and -B in the olfactory bulb
    Celine Plachez
    The University of Maryland, Baltimore, School of Medicine, Baltimore, Maryland 21201 1559, USA
    J Comp Neurol 520:3135-49. 2012
    The nuclear factor one (NFI) family of transcription factors consists of four members in vertebrates, NFIA, NFIB, NFIC, and NFIX, which share a highly conserved N-terminal DNA-binding domain...
  5. ncbi Comparative chromosomal studies of E. caballus (ECA) and E. przewalskii (EPR) in a female F1 hybrid
    E Ahrens
    Department of Animal Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    J Anim Breed Genet 122:97-102. 2005
    ..However, nuclear factor I (NFIA) and immunoglobulin lambda (IGL@), primarily assigned to ECA 5q, mapped to ECA 7 and EPR 6 respectively...
  6. pmc Evidence that nuclear factor IA inhibits repair after white matter injury
    Stephen P J Fancy
    Departments of Pediatrics and Neurosurgery, Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine and Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA, USA
    Ann Neurol 72:224-33. 2012
    ..Here we have investigated the role of the transcription factor nuclear factor IA (NFIA) in oligodendrocyte progenitor differentiation during developmental and regenerative myelination.
  7. ncbi MicroRNAs function on a new level
    Ryan M O'Connell
    University of Utah
    Blood 119:3875-6. 2012
    ..The authors provide evidence that miR-223 binds to specific sites within the promoter of its target gene Nfia and represses transcription by influencing epigenetic events...
  8. pmc Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis
    Peng Kang
    Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 74:79-94. 2012
    ..b>NFIA is a transcription factor that plays a crucial role in the onset of gliogenesis; we found that its induction is ..
  9. ncbi Imaging, anatomical, and molecular analysis of callosal formation in the developing human fetal brain
    Tianbo Ren
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:191-204. 2006
    ..we have identified that molecules involved in mouse callosal development, including Slit, Robo, Netrin1, DCC, Nfia, Emx1, and GAP-43, are all expressed in human fetal brain...
  10. doi Adiponectin, adiponectin receptors, and epigenetic regulation of adipogenesis
    T Kadowaki
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cold Spring Harb Symp Quant Biol 76:257-65. 2011
    ..PPARγ and CCAAT-enhancer binding proteins (C/EBPs) on the top list, consistent with their crucial roles in adipogenic transcription, and also revealed NFIA and NFIB to be important regulators of proper adipocyte differentiation.
  11. ncbi The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord
    Benjamin Deneen
    Division of Biology 216 76, California Institute of Technology, 1201 East California Boulevard, Pasadena, California 91125, USA
    Neuron 52:953-68. 2006
    ..b>NFIA is both necessary and sufficient for GLAST induction in the VZ...
  12. pmc A genome-wide survey of transgenerational genetic effects in autism
    Kathryn M Tsang
    Department of Psychiatry and Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e76978. 2013
    ..candidate genes including: PCDH9, FOXP1, GABRB3, NRXN1, RELN, MACROD2, FHIT, RORA, CNTN4, CNTNAP2, FAM135B, LAMA1, NFIA, NLGN4X, RAPGEF4, and SDK1...
  13. pmc The transcription factor gene Nfib is essential for both lung maturation and brain development
    George Steele-Perkins
    State University of New York at Buffalo, Dept of Biochemistry, 140 Farber Hall, 3435 Main St, Buffalo, NY 14214 3000, USA
    Mol Cell Biol 25:685-98. 2005
    ..We showed previously that Nfia-deficient mice exhibit agenesis of the corpus callosum and other forebrain defects, whereas Nfic-deficient mice ..
  14. doi A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder
    Heon Jeong Lee
    Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea
    J Affect Disord 145:200-7. 2013
    ..The use of subphenotypes may be an effective approach for genetic studies of complex diseases. Manic episodes with a seasonal pattern may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically...
  15. pmc miR-29 promotes murine osteoclastogenesis by regulating osteoclast commitment and migration
    Tiziana Franceschetti
    From the Center for Molecular Medicine and
    J Biol Chem 288:33347-60. 2013
    ..Moreover, miR-29 targets RNAs associated with the macrophage lineage: Gpr85 (G protein-coupled receptor 85), Nfia (nuclear factor I/A), and Cd93...
  16. pmc A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function
    Eleonora Porcu
    Istituto di Ricerca Genetica e Biomedica IRGB, Consiglio Nazionale delle Ricerche, c o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy
    PLoS Genet 9:e1003266. 2013
    ..Here we report 26 independent associations, including several novel loci for TSH (PDE10A, VEGFA, IGFBP5, NFIA, SOX9, PRDM11, FGF7, INSR, ABO, MIR1179, NRG1, MBIP, ITPK1, SASH1, GLIS3) and FT4 (LHX3, FOXE1, AADAT, NETO1/FBXO15,..
  17. doi Computational prediction of the polyQ and CAG repeat spinocerebellar ataxia network based on sequence identity to untranslated regions
    Jean L Spence
    Omnitron Biosciences, USA
    Gene 509:273-81. 2012
    ..UGUUU repeats were identified as an abundant motif in the SCA network and PAXIP1, CELF2, CREBBP, EBF1, PLEKHG4, SRSF4, C5orf42, NFIA, STK24, and YWHAG were identified as statistically significant proteins in the polyQ and PPP2R2B network.
  18. pmc Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk
    Marylyn D Ritchie
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA
    Circulation 127:1377-85. 2013
    ..ECG QRS duration, a measure of cardiac intraventricular conduction, varies ≈2-fold in individuals without cardiac disease. Slow conduction may promote re-entrant arrhythmias...
  19. pmc Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4
    Eric J Benner
    George and Jean Brumley Neonatal Perinatal Research Institute, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Nature 497:369-73. 2013
    ..by Thbs4 via direct Notch1 receptor binding and endocytosis to activate downstream signals, including increased Nfia transcription factor expression important for glia production...
  20. pmc Heterozygosity for nuclear factor one x affects hippocampal-dependent behaviour in mice
    Lachlan Harris
    The School of Biomedical Sciences, The University of Queensland, Brisbane, Australia
    PLoS ONE 8:e65478. 2013
    ..of the hippocampus is the Nuclear factor one (Nfi) family, which encodes four site-specific transcription factors, NFIA, NFIB, NFIC and NFIX...
  21. pmc Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups
    Laura A Genovesi
    Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia
    Proc Natl Acad Sci U S A 110:E4325-34. 2013
    ..mechanisms of action of subnetworks and used an in vivo model to confirm a role for a highly ranked candidate gene, Nfia, in promoting MB formation...
  22. pmc Oncolytic effects of parvovirus H-1 in medulloblastoma are associated with repression of master regulators of early neurogenesis
    Jeannine Lacroix
    Division of Tumor Virology, Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, Heidelberg, Germany Department of Pediatric Hematology, Oncology and Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg, Germany
    Int J Cancer 134:703-16. 2014
    ..of key regulators of early neurogenesis shown to confer poor prognosis in MB such as ZIC1, FOXG1B, MYC, and NFIA. In MB cell lines with genomic amplification of MYC, expression of MYC was the single gene most significantly ..
  23. doi Reverse flow injection analysis method for catalytic spectrophotometric determination of iron in estuarine and coastal waters: a comparison with normal flow injection analysis
    Yongming Huang
    State Key Laboratory of Marine Environmental Science, Environmental Science Research Center, Xiamen University, Xiamen 361005, China
    Talanta 93:86-93. 2012
    ..The method detection limit was 0.40 nmol L(-1), lower than half of that of normal flow injection analysis (nFIA) method. The sample throughput was 10h(-1) with triplicate determination, compared with 4h(-1) for nFIA-DPD method...
  24. pmc Molecular regulation of the developing commissural plate
    Randal X Moldrich
    Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia
    J Comp Neurol 518:3645-61. 2010
    ..Disruption of the dorsal domains occurred in strains with commissural defects such as Emx2 and Nfia knockout mice but commissural plate patterning was normal in other acallosal strains such as Satb2(-/-)...
  25. pmc Astrocyte precursor response to embryonic brain injury
    Miriam S Domowicz
    Department of Pediatrics, The University of Chicago Medical Center, 5841 S Maryland Avenue, MC 5058, Chicago, IL 60637, USA
    Brain Res 1389:35-49. 2011
    ..Increased expression of NFIA, SOX9 and GLAST at the wound site and in the ventricular zone (VZ) of the injured tecta indicated an astroglial ..
  26. doi NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1
    Michael Piper
    Queensland Brain Institute, The University of Queensland, Brisbane, Australia
    J Neurosci 30:9127-39. 2010
    ..Nuclear factor I A (Nfia), a gene known to regulate spinal cord and neocortical development, has recently been implicated as acting ..
  27. pmc NMDA-induced neuronal survival is mediated through nuclear factor I-A in mice
    Sika Zheng
    Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Clin Invest 120:2446-56. 2010
    ..Additional evidence of the neuroprotective effects of NFI-A was provided by the observations that Nfia(-/-) neurons were highly sensitive to NMDA-induced excitotoxicity and were more susceptible to developmental cell ..
  28. doi A novel 1p31.3p32.2 deletion involving the NFIA gene detected by array CGH in a patient with macrocephaly and hypoplasia of the corpus callosum
    Udo Koehler
    Medizinisch Genetisches Zentrum München, Bayerstr 3 5, 80335, Munich, Germany
    Eur J Pediatr 169:463-8. 2010
    ..To our knowledge, there have been six cases documented to date. Five of these cases, where the NFIA gene is involved, show complex central nervous system malformations and in some cases urinary tract defects...
  29. pmc Nuclear factor IA is expressed in astrocytomas and is associated with improved survival
    Hae Ri Song
    Departments of Neurosurgery and Neurology, New York University, School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Neuro Oncol 12:122-32. 2010
    Nuclear factor IA (NFIA) is a transcription factor that specifies glial cell identity and promotes astrocyte differentiation during embryonic development. Its expression and function in gliomas are not known...
  30. pmc Mesenchymal nuclear factor I B regulates cell proliferation and epithelial differentiation during lung maturation
    Yu Chih Hsu
    Department of Biochemistry, Developmental Genomics Group, Center of Excellence in Bioinformatics and Life Science, State University of New York at Buffalo, 701 Ellicott St Buffalo, NY 14203, USA
    Dev Biol 354:242-52. 2011
    The Nuclear factor I (NFI) transcription factor family consists of four genes (Nfia, Nfib, Nfic and Nfix) that regulate the development of multiple organ systems in mice and humans...
  31. pmc Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus
    Lakshmi Subramanian
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    Proc Natl Acad Sci U S A 108:E265-74. 2011
    ..Lhx2 overexpression was also able to override and suppress the activation of the GFAP promoter by Nfia, a Notch-regulated transcription factor that is required for gliogenesis...
  32. pmc Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes
    Erin N Smith
    Scripps Genomic Medicine and Scripps Translational Science Institute, La Jolla, California, United States of America
    PLoS Genet 7:e1002134. 2011
    ....
  33. pmc Characterisation of genome-wide association epistasis signals for serum uric acid in human population isolates
    Wenhua Wei
    MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom
    PLoS ONE 6:e23836. 2011
    ..However, SLC2A9 was found interacting with multiple loci across the genome, with NFIA-SLC2A9 and SLC2A9-ESRRAP2 being significant based on a threshold derived for interactions between GWA significant ..
  34. pmc Global mapping of cell type-specific open chromatin by FAIRE-seq reveals the regulatory role of the NFI family in adipocyte differentiation
    Hironori Waki
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    PLoS Genet 7:e1002311. 2011
    ..Overexpression of NFIA in 3T3-L1 cells resulted in robust induction of these genes and lipid droplet formation without differentiation ..
  35. doi Chromosome 1p32-p31 deletion syndrome: prenatal diagnosis by array comparative genomic hybridization using uncultured amniocytes and association with NFIA haploinsufficiency, ventriculomegaly, corpus callosum hypogenesis, abnormal external genitalia, and
    Chih Ping Chen
    Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
    Taiwan J Obstet Gynecol 50:345-52. 2011
    To present prenatal diagnosis of chromosome 1p32-p31 deletion syndrome with NFIA haploinsufficiency, ventriculomegaly, corpus callosum hypogenesis, abnormal external genitalia, and intrauterine growth restriction and to review the ..
  36. doi Clinically relevant single gene or intragenic deletions encompassing critical neurodevelopmental genes in patients with developmental delay, mental retardation, and/or autism spectrum disorders
    Fady M Mikhail
    Department of Genetics, University of Alabama at Birmingham, 35294, USA
    Am J Med Genet A 155:2386-96. 2011
    ..These genes belong to four functional categories, including neuronal transcription factor genes (NFIA at 1p31.3, MEF2C at 5q14.3, andCAMAT1at 1p36.23p36.31), neuron-specific splicing factor genes (RBFOX1 at 16p13.2p13...
  37. ncbi Genomic organization, splice products and mouse chromosomal localization of genes for transcription factor Nuclear Factor One
    Albert Gründer
    Institut für Biologie III Genetik, Albert Ludwigs Universitat, Schaenzlestrasse 1, D 79104, Freiburg, Germany
    Gene 304:171-81. 2003
    Transcription factor Nuclear Factor One (NFI) proteins are derived from a small family of four vertebrate genes (NFIA, B, C and X), all of which produce a fair number of protein variants by alternative splicing...
  38. doi Targets of the nuclear factor I regulon involved in early and late development of postmitotic cerebellar granule neurons
    Wei Wang
    Department of Cellular and Molecular Physiology and Program in Neuroscience, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Neurosci Res 88:258-65. 2010
    ..Consistent with this, synapsin I was greatly reduced within the internal granule cell layer of P17 Nfia-null mice...
  39. doi NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls beta-globin and G-CSF receptor expression
    Linda Marie Starnes
    Department of Histology and Medical Embryology, University La Sapienza, Rome, Italy
    Blood 114:1753-63. 2009
    ..Altogether, these results indicate that, in early hematopoiesis, the NFI-A expression level acts as a novel factor channeling HPCs into either the E or G lineage...
  40. doi Nuclear factor I regulates brain fatty acid-binding protein and glial fibrillary acidic protein gene expression in malignant glioma cell lines
    Miranda Brun
    Department of Oncology, Cross Cancer Institute, University of Alberta, Alberta, Canada
    J Mol Biol 391:282-300. 2009
    ..We show by gel shifts that all four members of the NFI family (NFIA, NFIB, NFIC, and NFIX) bind to B-FABP and GFAP NFI consensus sites...
  41. ncbi A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis
    Francesco Fazi
    Department of Histology and Medical Embryology, University of Rome La Sapienza and San Raffaele Biomedical Science Park of Rome, Via di Castel Romano 100, 00128, Rome, Italy
    Cell 123:819-31. 2005
    ..Altogether, our data indicate that miR-223 plays a crucial role during granulopoiesis and point to the NFI-A repression as an important molecular pathway mediating gene reprogramming in this cell lineage...
  42. ncbi Organization of gene structure and expression of nuclear factor 1 family in rat
    Shigehiro Osada
    Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    DNA Seq 16:151-5. 2005
    The nuclear factor 1 (NF1) family proteins are encoded by four different genes (Nfia, Nfib, Nfic and Nfix) and regulate gene expression and DNA replication...
  43. pmc FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner
    Fred B Berry
    Department of Ophthalmology, University of Alberta, Edmonton, AB, Canada
    Mol Cell Biol 25:1415-24. 2005
    ....
  44. pmc Distributions of Z-DNA and nuclear factor I in human chromosome 22: a model for coupled transcriptional regulation
    P Christoph Champ
    Department of Biochemistry and Biophysics, ALS 2011, Oregon State University, Corvallis, OR 97331, USA
    Nucleic Acids Res 32:6501-10. 2004
    ..2001) Cell, 106, 309-318]. The results from this study will facilitate the design of experimental studies to test the generality of this mechanism for other genes in the cell...
  45. ncbi A role for nuclear factor I in the intrinsic control of cerebellar granule neuron gene expression
    Wei Wang
    University of Massachusetts Medical School, Department of Molecular and Cellular Physiology, 55 Lake Ave N, Worcester, MA 01655, USA
    J Biol Chem 279:53491-7. 2004
    ..Furthermore, analyses of gene knockout mice revealed that Nfia is specifically required for normal expression of the GABRA6 gene in cerebellar granule neurons...
  46. ncbi NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene
    Hua Xu
    Department of Pediatrics, Steele Memorial Children s Research Center, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Am J Physiol Gastrointest Liver Physiol 288:G175-81. 2005
    ..This study has thus identified a new target gene in the small intestinal epithelium that is directly regulated by NF1 transcriptional factor(s)...
  47. pmc Essential role for NFI-C/CTF transcription-replication factor in tooth root development
    George Steele-Perkins
    Lerner Research Institute, Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Mol Cell Biol 23:1075-84. 2003
    ..Four genes encoding nuclear factor I (NFI) transcription-replication proteins are present in the mouse genome: Nfia, Nfib, Nfic, and NFIX: In order to elucidate its physiological role(s), we disrupted the Nfic gene in mice...
  48. ncbi Abnormal development of forebrain midline glia and commissural projections in Nfia knock-out mice
    Tianzhi Shu
    Department of Anatomy and Neurobiology, and the Program in Neuroscience, The University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 23:203-12. 2003
    ..1997; for review, see Gronostajski, 2000). All four NFI genes are expressed in embryonic mouse brain, with Nfia, Nfib, and Nfix being expressed highly in developing cortex (Chaudhry et al., 1997)...
  49. ncbi Exon structure of the nuclear factor I DNA-binding domain from C. elegans to mammals
    C F Fletcher
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Mamm Genome 10:390-6. 1999
    ..elegans NFI genes. The four murine NFI genes are on Chrs 4 (Nfia and Nfib), 8 (Nfix), and 10 (Nfic), suggesting early duplication of the genes and dispersal throughout the genome...
  50. ncbi CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription
    P Leahy
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4935, USA
    J Biol Chem 274:8813-22. 1999
    ..NFI-A combines with dexamethasone or thyroid hormone in an additive manner to stimulate PEPCK gene transcription. We conclude that CBP coordinates the action of the multiple factors known to control transcription of the PEPCK gene...
  51. ncbi Expression patterns of the four nuclear factor I genes during mouse embryogenesis indicate a potential role in development
    A Z Chaudhry
    Department of Cancer Biology, Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    Dev Dyn 208:313-25. 1997
    ..We have isolated cDNAs from all four murine NFI genes (gene designations Nfia, Nfib, Nfic, and Nfix), assessed the embryonic and postnatal expression patterns of the NFI genes, and determined ..
  52. ncbi Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH
    F Qian
    Institut fur Biologie III, Universitat Freiburg, Germany
    Genomics 28:66-73. 1995
    ..position of NFI genes in the human genome, we isolated partial cDNA sequences derived from four independent genes: NFIA, NFIB, NFIC, and NFIX...
  53. ncbi Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon
    Pontus C Holm
    Institute for Stem Cell Research, National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg Munich, Germany
    Mol Cell Neurosci 34:99-119. 2007
    ..Pax6-deficient cortex the expression levels of various transcription factors involved in neurogenesis (like Satb2, Nfia, AP-2gamma, NeuroD6, Ngn2, Tbr2, Bhlhb5) and the retinoic acid signalling molecule Rlbp1 were reduced...
  54. pmc Nuclear factor I X deficiency causes brain malformation and severe skeletal defects
    Katrin Driller
    Institut fur Biologie III, Fakultat fur Biologie, Albert Ludwigs Universitat Freiburg, Schanzlestrasse 1, D 79104 Freiburg, Germany
    Mol Cell Biol 27:3855-3867. 2007
    The transcription factor family of nuclear factor I (NFI) proteins is encoded by four closely related genes: Nfia, Nfib, Nfic, and Nfix...
  55. doi Absence of the transcription factor Nfib delays the formation of the basilar pontine and other mossy fiber nuclei
    Asli Kumbasar
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Comp Neurol 513:98-112. 2009
    ..While the mossy fiber nuclei of the caudal medulla do form, they also exhibit a developmental delay. Nfia and Nfix null mice exhibit no apparent pontine phenotype, implying specificity in the action of NFI family members...
  56. doi Nuclear factor one transcription factors in CNS development
    Sharon Mason
    Queensland Brain Institute, The University of Queensland, Building 79, St Lucia, 4072, Australia
    Mol Neurobiol 39:10-23. 2009
    ..b>Nfia null mice display a striking brain phenotype including agenesis of the corpus callosum and malformation of midline ..
  57. pmc Nuclear factor I transcription factors regulate IGF binding protein 5 gene transcription in human osteoblasts
    LAURA A PEREZ-CASELLAS
    Jerry L Pettis Memorial Veterans Affairs Medical Center, Loma Linda, CA 92357, USA
    Biochim Biophys Acta 1789:78-87. 2009
    ..Nfix was less active and Nfia and Nfic were inhibitory...
  58. doi Gene expression profiles following exposure to a developmental neurotoxicant, Aroclor 1254: pathway analysis for possible mode(s) of action
    Joyce E Royland
    Cellular and Molecular Toxicology Branch, Neurotoxicology Division, NHEERL, ORD, U S Environmental Protection Agency, Research Triangle Park, NC, USA
    Toxicol Appl Pharmacol 231:179-96. 2008
    ..Ryr2, Trio, Fert2, Ptk2b), axonal guidance (Lum, Mxd3, Akap11, Gucy1b3), aryl hydrocarbon receptor signaling (Nfia, Col1a2), and transcripts involved in cell proliferation (Gspt2, Cdkn1c, Ptk2b) and differentiation (Ifitm31, Hpca, ..
  59. pmc The transcription factor Nfix is essential for normal brain development
    Christine E Campbell
    Dept of Biochemistry and New York State Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, 3435 Main St, Buffalo, NY 14214, USA
    BMC Dev Biol 8:52. 2008
    ..We showed previously that Nfia-deficient mice exhibit agenesis of the corpus callosum and other forebrain defects; Nfib-deficient mice have ..
  60. doi Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by oligonucleotide microarray and real-time quantitative PCR
    Carlos A Scrideli
    Department of Pediatrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Neurooncol 88:281-91. 2008
    ..00001 for CDKN2C, CKS2, EEF1A1, EMP3, PDPN, BNIP2, CA12, CD34, CDC42EP4, PPIE, SNAI2, GDF15 and MMP23b; and NFIA (P: 0.0001), GPS1 (P: 0.0003), LAMA1 (P: 0.002), STIM1 (P: 0.006), and TASP1 (P: 0.01)...
  61. doi Nuclear factor I gene expression in the developing forebrain
    Celine Plachez
    University of Maryland, Baltimore, School of Medicine, Baltimore, Maryland, USA
    J Comp Neurol 508:385-401. 2008
    Three members of the Nuclear Factor I (Nfi) gene family of transcription factors; Nfia, Nfib, and Nfix are highly expressed in the developing mouse brain...
  62. ncbi Cross-talk of expression quantitative trait loci within 2 interacting blood pressure quantitative trait loci
    Norman H Lee
    Department of Pharmacology and Physiology, George Washington University, Washington, DC, USA
    Hypertension 50:1126-33. 2007
    ..The results uncovered an interaction between 2 transcription factor genes, Dmrta2 and Nfia. Furthermore, the "biological signature" elicited by these 2 transcription factors was differential between the ..
  63. ncbi Nuclear factor I coordinates multiple phases of cerebellar granule cell development via regulation of cell adhesion molecules
    Wei Wang
    Department of Cellular and Molecular Physiology and Program in Neuroscience, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Neurosci 27:6115-27. 2007
    ..In postnatal day 17 Nfia-deficient mice, parallel fibers were greatly diminished and disoriented, CGN dendrite formation was dramatically ..
  64. pmc NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects
    Weining Lu
    Genetics Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 3:e80. 2007
    ..related CNS malformations and in some cases urinary tract defects, and also haploinsufficiency for the NFIA transcription factor gene due to chromosomal translocation or deletion...
  65. pmc Gene expression analysis of nuclear factor I-A deficient mice indicates delayed brain maturation
    Yong Wee Wong
    Zentrum fur Molekulare Neurobiologie Hamburg, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Genome Biol 8:R72. 2007
    ..Previous studies have shown that disruption of the Nfia gene in mice leads to perinatal lethality, corpus callosum agenesis, and hydrocephalus.
  66. ncbi Isolation of complementary DNAs encoding a cerebellum-enriched nuclear factor I family that activates transcription from the mouse myelin basic protein promoter
    T Inoue
    Division of Behavior and Neurobiology, National Institute for Basic Biology, Okazaki, Japan
    J Biol Chem 265:19065-70. 1990
    ..NFI-B is highly enriched in the cerebellum, in contrast with a ubiquitous NFI, CTF/NF-I. NFI-B proteins translated in vitro could bind to the MBP NFI site...
  67. pmc Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry
    Laura J Scott
    Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 106:7501-6. 2009
    ..37, P = 0.042). Although these results are promising, analysis of additional samples will be required to confirm that variant(s) in these regions influence BP risk...

Research Grants4

  1. Transcriptional regulation of pontine development
    E Litwack; Fiscal Year: 2009
    ..Mice lacking the Nfia gene exhibit a moderate reduction in BP size...
  2. Role of NFI in type II Cell Function
    CINDY BACHURSKI; Fiscal Year: 2006
    ..All NFI family members are expressed in adult Type II cells, however genetic inactivation of Nfib, but not Nfia, causes neonatal death by respiratory failure due to a block in lung maturation...
  3. Fate of Aggrecan-Expressing Progenitors in Gliogenesis
    Miriam Domowicz; Fiscal Year: 2004
    ..abstract_text> ..
  4. Mapping Gene Networks in Colon Cancer
    Norman H Lee; Fiscal Year: 2010
    ....