NFE2L2

Summary

Gene Symbol: NFE2L2
Description: nuclear factor, erythroid 2 like 2
Alias: HEBP1, NRF2, nuclear factor erythroid 2-related factor 2, nuclear factor erythroid-derived 2-like 2
Species: human

Top Publications

  1. ncbi Regulatory motifs for CREB-binding protein and Nfe2l2 transcription factors in the upstream enhancer of the mitochondrial uncoupling protein 1 gene
    Jong S Rim
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 277:34589-600. 2002
  2. pmc Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2
    Jingbo Pi
    Laboratory of Comparative Carcinogenesis, NCI at NIEHS, NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 45:651-8. 2008
  3. pmc Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta(12,14)-prostaglandin J(2) requires Nrf2
    Simona Bancos
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Cell Immunol 262:18-27. 2010
  4. pmc Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
    Akira Kobayashi
    Center for Tsukuba Advanced Research Alliance, Institute of Basic Medical Sciences, and JST ERATO Environmental Response Project, University of Tsukuba, Tsukuba 305 8575, Japan
    Mol Cell Biol 24:7130-9. 2004
  5. doi Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
    Tsutomu Ohta
    Center for Medical Genomics, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Cancer Res 68:1303-9. 2008
  6. pmc Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    K Itoh
    Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305 8577, Japan
    Genes Dev 13:76-86. 1999
  7. pmc Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
    Donna D Zhang
    Department of Biochemistry, University of Missouri Columbia, M121 Medical Sciences Building, Columbia, MO 65212, USA
    Mol Cell Biol 24:10941-53. 2004
  8. pmc The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
    Truyen Nguyen
    Schering Plough Research Institute, Summit, New Jersey 07901, USA
    J Biol Chem 284:13291-5. 2009
  9. pmc Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
    Xiao Jun Wang
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85721, USA
    Carcinogenesis 29:1235-43. 2008
  10. ncbi Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
    Nobunao Wakabayashi
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
    Nat Genet 35:238-45. 2003

Research Grants

  1. Myocardial salvage via coordinated induction of endogenous cardiac antioxidants
    Yunbo Li; Fiscal Year: 2010
  2. Quercitrin functions as an antioxidant and protects UV-induced carcinogenesis
    Zhuo Zhang; Fiscal Year: 2012
  3. Role of Nrf2 signaling in modulating ethanol-induced teratogenesis
    Shao Yu Chen; Fiscal Year: 2012
  4. Marta Margeta; Fiscal Year: 2015
  5. Enhancing Nrf2 by Sulforaphane Treatment in COPD
    Robert A Wise; Fiscal Year: 2012
  6. Mustafa F Lokhandwala; Fiscal Year: 2016
  7. Mechanisms of Embryo Response to Oxidative Stress
    Mark E Hahn; Fiscal Year: 2013
  8. Thu H Le; Fiscal Year: 2015
  9. Novel strategy to mitigate and treat radiation combined infection injury by targe
    Shyam Biswal; Fiscal Year: 2012
  10. Pulmonary effects of biomass fuel indoor PM from rural India
    Shyam Biswal; Fiscal Year: 2013

Detail Information

Publications321 found, 100 shown here

  1. ncbi Regulatory motifs for CREB-binding protein and Nfe2l2 transcription factors in the upstream enhancer of the mitochondrial uncoupling protein 1 gene
    Jong S Rim
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 277:34589-600. 2002
    ..Co-transfections with an Nfe2l2 expression vector and a luciferase reporter construct of the Ucp1 enhancer region provide additional evidence that ..
  2. pmc Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2
    Jingbo Pi
    Laboratory of Comparative Carcinogenesis, NCI at NIEHS, NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 45:651-8. 2008
    ..Transcription factor Nrf2-mediated antioxidant response represents a critical cellular defense mechanism, and emerging data suggest that ..
  3. pmc Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta(12,14)-prostaglandin J(2) requires Nrf2
    Simona Bancos
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Cell Immunol 262:18-27. 2010
    ..Using siRNA directed against the transcription factor Nrf2 and B cells isolated from Nrf2-deficient mice, we show that HO-1 induction by 15d-PGJ(2) is dependent on Nrf2...
  4. pmc Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
    Akira Kobayashi
    Center for Tsukuba Advanced Research Alliance, Institute of Basic Medical Sciences, and JST ERATO Environmental Response Project, University of Tsukuba, Tsukuba 305 8575, Japan
    Mol Cell Biol 24:7130-9. 2004
    Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying enzymes and antioxidant stress proteins in response to electrophilic agents and oxidative stress...
  5. doi Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
    Tsutomu Ohta
    Center for Medical Genomics, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Cancer Res 68:1303-9. 2008
    Oxidative and electrophilic stresses are sensed by Keap1, which activates Nrf2 to achieve cytoprotection by regulating the expression of drug-metabolizing and antioxidative stress enzymes/proteins...
  6. pmc Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    K Itoh
    Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305 8577, Japan
    Genes Dev 13:76-86. 1999
    Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated induction of phase II detoxifying and oxidative stress enzyme genes...
  7. pmc Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
    Donna D Zhang
    Department of Biochemistry, University of Missouri Columbia, M121 Medical Sciences Building, Columbia, MO 65212, USA
    Mol Cell Biol 24:10941-53. 2004
    The bZIP transcription factor Nrf2 controls a genetic program that protects cells from oxidative damage and maintains cellular redox homeostasis...
  8. pmc The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
    Truyen Nguyen
    Schering Plough Research Institute, Summit, New Jersey 07901, USA
    J Biol Chem 284:13291-5. 2009
    A major mechanism in the cellular defense against oxidative or electrophilic stress is activation of the Nrf2-antioxidant response element signaling pathway, which controls the expression of genes whose protein products are involved in ..
  9. pmc Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
    Xiao Jun Wang
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85721, USA
    Carcinogenesis 29:1235-43. 2008
    ..Here, we report that inhibition of NF-E2-related factor 2 (Nrf2) may be a promising strategy to combat chemoresistance...
  10. ncbi Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
    Nobunao Wakabayashi
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
    Nat Genet 35:238-45. 2003
    Transcription factor Nrf2 (encoded by Nfe2l2) regulates a battery of detoxifying and antioxidant genes, and Keap1 represses Nrf2 function...
  11. pmc Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
    Donna D Zhang
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65212, USA
    Mol Cell Biol 23:8137-51. 2003
    ..The bZIP transcription factor Nrf2 has emerged as a key regulator of this cancer-preventive genetic program...
  12. pmc Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region
    P Moi
    Istituto di Clinica e Biologia dell Età Evolutiva, Universita di Cagliari, Italy
    Proc Natl Acad Sci U S A 91:9926-30. 1994
    ..Here, we report the characterization of one of the clones isolated. The gene, which we named Nrf2 (NF-E2-related factor 2), is encoded within a 2...
  13. pmc Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
    Tatsuhiro Shibata
    Cancer Genomics Project, Pathology Division, Center for Medical Genomics, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Proc Natl Acad Sci U S A 105:13568-73. 2008
    The nuclear factor E2-related factor 2 (Nrf2) is a master transcriptional activator of genes encoding numerous cytoprotective enzymes that are induced in response to environmental and endogenously derived oxidative/electrophilic agents...
  14. ncbi Mechanistic studies of the Nrf2-Keap1 signaling pathway
    Donna D Zhang
    Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, USA
    Drug Metab Rev 38:769-89. 2006
    ..cellular defense mechanisms against oxidative stress or electrophiles is mediated by the transcription factor Nrf2. Under the basal condition, Nrf2-dependent transcription is repressed by a negative regulator Keap1...
  15. pmc BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase
    Manabu Furukawa
    Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Mol Cell Biol 25:162-71. 2005
    ..we report that the human BTB-Kelch protein Keap1, a negative regulator of the antioxidative transcription factor Nrf2, binds to CUL3 and Nrf2 via its BTB and Kelch domains, respectively...
  16. ncbi Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival
    Mi Kyoung Kwak
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Biol Chem 278:8135-45. 2003
    ..putative molecular sensor for inducers is Keap1, a sulfhydryl-rich protein that sequesters the transcription factor Nrf2 in the cytoplasm...
  17. doi The NRF2 gene variant, -653G/A, is associated with nephritis in childhood-onset systemic lupus erythematosus
    E J Córdova
    Instituto Nacional de Medicina Genomica, Mexico City, Mexico
    Lupus 19:1237-42. 2010
    ..Kidney malfunction, an aggressive characteristic of this disease, is not present in all affected individuals. The Nrf2-Keap1 pathway is important in protecting against oxidative stress and inflammation...
  18. pmc Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex
    Liam Baird
    Jacqui Wood Cancer Centre, Division of Cancer Research, Medical Research Institute, University of Dundee, Dundee DD1 9SY, United Kingdom
    Proc Natl Acad Sci U S A 110:15259-64. 2013
    The transcription factor NF-E2 p45-related factor 2 (Nrf2), a master regulator of cytoprotective genes, is controlled by dimeric Kelch-like ECH associated protein 1 (Keap1), a substrate adaptor protein for Cullin3/RING-box protein 1 ..
  19. doi Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease
    Masaru Suzuki
    First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    Am J Respir Cell Mol Biol 39:673-82. 2008
    ..are one of the sources of various antioxidant and detoxification enzymes for which NF-E2-related factor 2 (Nrf2) is a key transcriptional factor...
  20. ncbi Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation
    Fei Hong
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85721, USA
    J Biol Chem 280:31768-75. 2005
    Activation of the transcription factor Nrf2 regulates expression of phase II enzymes and other adaptive responses to electrophile and oxidant stress...
  21. pmc Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
    Aimee L Eggler
    Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, IL 60607, USA
    Proc Natl Acad Sci U S A 102:10070-5. 2005
    ..sensor protein Kelch-like ECH-associated protein 1 (Keap1) and the transcription factor NF-E2-related factor 2 (Nrf2). Under basal conditions, Keap1 sequesters Nrf2 in the cytoplasm by binding to its Neh2 domain...
  22. ncbi Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone oxidoreductase1 gene
    S Dhakshinamoorthy
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 275:40134-41. 2000
    ..The nuclear transcription factor Nrf2 and Nrf1 bind to the ARE and positively regulate expression and induction of the NQO1 and GST Ya genes...
  23. ncbi Lipoteichoic acid induces HO-1 expression via the TLR2/MyD88/c-Src/NADPH oxidase pathway and Nrf2 in human tracheal smooth muscle cells
    I Ta Lee
    Department of Physiology and Pharmacology
    J Immunol 181:5098-110. 2008
    ..scavenger (N-acetyl-l-cysteine) or by transfection with small interfering RNAs of Src and NF-E2-related factor 2 (Nrf2)...
  24. ncbi Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease
    Lauren M Aleksunes
    Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269 3092, USA
    Toxicol Pathol 35:459-73. 2007
    Transcription factor NF-E2-related factor 2 (Nrf2) belongs to the basic region-leucine zipper family and is activated in response to electrophiles and reactive oxygen species...
  25. doi Role of a fetal defence mechanism against oxidative stress in the aetiology of preeclampsia
    Christoph Jan Wruck
    Department of Anatomy and Cell Biology, RWTH Aachen University, Aachen, Germany
    Histopathology 55:102-6. 2009
    ..The aim of this study was to elucidate the placental defence mechanisms employed against oxidative stress and, in particular, the specific role of nuclear factor erythroid 2-related factor 2 (Nrf2).
  26. pmc Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features
    Luisa M Solis
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 16:3743-53. 2010
    To understand the role of nuclear factor erythroid-2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) in non-small cell lung cancer (NSCLC), we studied their expression in a large series of tumors with annotated ..
  27. pmc CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation
    Hyo Jin Kang
    Departments of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    J Biol Chem 285:21258-68. 2010
    ..cells respond to this damage by increased transcription of cytoprotective phase II genes, which are regulated by NRF2. Previously, it has been shown that NRF2 protein levels increase after oxidative stress because its negative ..
  28. pmc Multiple nuclear localization signals function in the nuclear import of the transcription factor Nrf2
    Melanie Theodore
    School of Medicine, Meharry Medical College, Nashville, TN 37208 3599, USA
    J Biol Chem 283:8984-94. 2008
    Nuclear factor erythroid 2-related factor 2 (Nrf2) mediates the transcriptional response of cells to oxidative stress and is translocated into the nucleus following, or concomitant with, its activation by electrophiles or reactive oxygen ..
  29. pmc KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response
    Zheng Sun
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
    Mol Cell Biol 31:1800-11. 2011
    The transcription factor Nrf2 has emerged as a master regulator of cellular redox homeostasis...
  30. doi The role of Nrf2 in migration and invasion of human glioma cell U251
    Hao Pan
    Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, People s Republic of China
    World Neurosurg 80:363-70. 2013
    NF-E2-related factor 2 (Nrf2) is a transcription factor that is related to tumor cell multidrug resistance and proliferation. Here we studied the involvement of Nrf2 in the migration and invasion of human U251 glioma cells.
  31. pmc Nrf2 activates augmenter of liver regeneration (ALR) via antioxidant response element and links oxidative stress to liver regeneration
    Rania Dayoub
    Department of Pediatrics and Juvenile Medicine, University of Regensburg Hospital, Germany
    Mol Med 19:237-44. 2013
    ..can be impaired by permanent oxidative stress and activation of nuclear factor erythroid 2-related factor 2 (Nrf2), known to regulate the cellular antioxidant response, and has been shown to improve the process of liver ..
  32. pmc Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine
    Hong Quan Duong
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
    Int J Oncol 44:959-69. 2014
    ..The effect of PIK-75 on the level and activity of NRF2 was characterized using various assays including reporter gene, quantitative PCR, DNA-binding and western blot ..
  33. ncbi Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene
    S Dhakshinamoorthy
    Department of Pharmacology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, TX 77030, USA
    Oncogene 20:3906-17. 2001
    Antioxidant response element (ARE) and nuclear transcription factor Nrf2 are known to regulate expression and coordinated induction of NQO1 and other detoxifying enzyme genes in response to antioxidants and xenobiotics...
  34. ncbi Role of the Nrf2-antioxidant system in cytotoxicity mediated by anticancer cisplatin: implication to cancer cell resistance
    Jeong Min Cho
    College of Pharmacy, Yeungnam University, Gyeongsangbuk do, South Korea
    Cancer Lett 260:96-108. 2008
    ..In the present study, the potential involvement of the transcription factor Nrf2 in determination of cisplatin cytotoxicity has been investigated...
  35. doi Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
    Tatsuhiro Shibata
    Cancer Genomics Project, National Cancer Center Research Institute, Tokyo, Japan Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 135:1358-1368, 1368.e1-4. 2008
    ..We attempted to examine whether deregulation of Nrf2, a master transcriptional factor of various cytoprotective genes against oxidative stress, plays a role in the ..
  36. doi Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer
    Shinsuke Homma
    Department of Respiratory Medicine, University of Tsukuba, Tsukuba, Japan
    Clin Cancer Res 15:3423-32. 2009
    NF-E2-related factor 2 (Nrf2), a key transcription regulator for antioxidant and detoxification enzymes, is abundantly expressed in cancer cells...
  37. pmc A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62
    Alexandria Lau
    Department of Pharmacology and Toxicology, University of Arizona, 1703 East Mabel Street, Tucson, AZ 85721 0207, USA
    Mol Cell Biol 30:3275-85. 2010
    ..The Nrf2-Keap1 pathway functions as a critical regulator of the cell's defense mechanism against oxidative stress by ..
  38. pmc MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism
    Muhua Yang
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Breast Cancer Res Treat 129:983-91. 2011
    NF-E2-related factor 2 (Nrf2) is an important transcription factor involved in antioxidant response. Nrf2 binds antioxidant response elements (ARE) within promoters of genes encoding detoxification enzymes (e.g...
  39. pmc Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia
    Nisreen Kweider
    Department of Anatomy and Cell Biology, RWTH Aachen University, 52074 Aachen, Germany
    J Biol Chem 286:42863-72. 2011
    ..Here, we show that VEGF activated Nrf2, the main regulating factor of the intracellular redox balance, in the cytotrophic cell line BeWo...
  40. pmc Polymorphisms in the transcription factor NRF2 and forearm vasodilator responses in humans
    Ewa D Marczak
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Pharmacogenet Genomics 22:620-8. 2012
    ..As NRF2 is a key transcription factor in antioxidant defense, we aimed to determine whether polymorphisms within the promoter region of the gene encoding NRF2 (NFE2L2) would significantly modify vasodilator responses in humans.
  41. pmc Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance
    Suryakant K Niture
    Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Free Radic Biol Med 57:119-31. 2013
    Nuclear transcription factor Nrf2 binds with the antioxidant-response element (ARE) in the promoter regions of cytoprotective genes, leading to their increased expression and cellular protection...
  42. doi Reactive oxygen species regulate FSH-induced expression of vascular endothelial growth factor via Nrf2 and HIF1α signaling in human epithelial ovarian cancer
    Zhenbo Zhang
    Department of Obstetrics and Gynecology, Shanghai Jiao Tong University, Affiliated First People s Hospital, Shanghai, PR China
    Oncol Rep 29:1429-34. 2013
    ..demonstrated that FSH induces reactive oxygen species (ROS) production and activates Nrf2 signaling...
  43. ncbi Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid
    Rentian Feng
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 280:27888-95. 2005
    ..Further studies indicated that chlorogenic acid could stimulate the nuclear translocation of Nrf2 (NF-E2-related factor) as well as subsequent induction of GSTA1 antioxidant response element (ARE)-mediated GST ..
  44. doi Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2
    Yanlin Zhang
    Research Center of Occupational Medicine, Third Hospital of Peking University, Peking, PR China
    Free Radic Res 42:362-71. 2008
    ..The induction of HO-1 and NQO1 by CHL was accompanied with the accumulation of transcription factor Nrf2 in nucleus and the activation of PI3K/Akt signalling pathway...
  45. doi Heme induces heme oxygenase 1 via Nrf2: role in the homeostatic macrophage response to intraplaque hemorrhage
    Joseph J Boyle
    Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Arterioscler Thromb Vasc Biol 31:2685-91. 2011
    ..These may be atheroprotective in view of raised heme oxygenase 1 (HO-1), CD163, and interleukin-10 expression and suppressed oxidative stress...
  46. ncbi Elevated peroxiredoxin 1, but not NF-E2-related factor 2, is an independent prognostic factor for disease recurrence and reduced survival in stage I non-small cell lung cancer
    Joo Heon Kim
    Department of Cell Stress Biology, Roswell Park Cancer Institute, State University of New York at Buffalo, Buffalo, New York, USA
    Clin Cancer Res 13:3875-82. 2007
    ..We recently cloned the prx1 promoter and found that NF-E2-related factor 2 (Nrf2) is a key transcription factor for prx1 up-regulation...
  47. ncbi The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm
    Laurie M Zipper
    Department of Pharmacology, University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53792, USA
    J Biol Chem 277:36544-52. 2002
    ..of phase II detoxification enzymes and antioxidant proteins is mediated by the Cap'N'Collar transcription factor, Nrf2, which is sequestered in the cytoplasm by the actin-binding protein Keap1...
  48. pmc DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
    Casey M Clements
    Department of Microbiology Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7295, USA
    Proc Natl Acad Sci U S A 103:15091-6. 2006
    ..This deficit is attributed to a loss of Nrf2 (nuclear factor erythroid 2-related factor), a master regulator of antioxidant transcriptional responses...
  49. doi NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
    John D Hayes
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Trends Biochem Sci 34:176-88. 2009
    Transcription factor nuclear factor-erythroid 2-related factor 2 (NRF2) controls cellular adaptation to oxidants and electrophiles by inducing antioxidant and detoxification genes in response to redox stress...
  50. ncbi Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1
    Truyen Nguyen
    Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 280:32485-92. 2005
    b>Nrf2 regulates the expression of genes encoding antioxidant proteins involved in cellular redox homeostasis...
  51. doi Polymeric black tea polyphenols induce phase II enzymes via Nrf2 in mouse liver and lungs
    Rachana Patel
    Advanced Centre for Treatment, Research, and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai 410 208, India
    Free Radic Biol Med 44:1897-911. 2008
    ..PBP extract induced transcriptional up-regulation of phase II enzymes in liver and lungs by increasing Nrf2-mediated antioxidant-responsive element (ARE) binding...
  52. pmc The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation
    Paul Nioi
    Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Mol Cell Biol 25:10895-906. 2005
    b>Nrf2 is a transcription factor critical for the maintenance of cellular redox homeostasis. We have previously found that Nrf2 is a labile protein, and its activation in cells under stress involves mechanisms leading to its stabilization...
  53. pmc Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling
    Shih Ching Lo
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    EMBO J 25:3605-17. 2006
    Keap1 is a BTB-Kelch substrate adaptor protein that regulates steady-state levels of Nrf2, a bZIP transcription factor, in response to oxidative stress...
  54. pmc Prevention of diabetic complications by activation of Nrf2: diabetic cardiomyopathy and nephropathy
    Bing Li
    Department of Nephrology, Second Hospital of Jilin University, Changchun 130042, China
    Exp Diabetes Res 2012:216512. 2012
    ..Transcription factor, NFE2-related factor 2 (Nrf2), is a master regulator of cellular detoxification response and redox status, and also provides a protective action ..
  55. doi Prolonged cigarette smoke exposure decreases heme oxygenase-1 and alters Nrf2 and Bach1 expression in human macrophages: roles of the MAP kinases ERK(1/2) and JNK
    D Goven
    INSERM U700, Universite Paris 7, Faculté de Médecine Denis Diderot site Bichat, Paris, France
    FEBS Lett 583:3508-18. 2009
    ..expression described in smoking-induced severe emphysema, via the nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1)-BTB and CNC homology 1, basic leucine zipper transcription factor 1 (..
  56. ncbi Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrin
    Ying Shan
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    FASEB J 20:2651-3. 2006
    ..Here we report that CoPP up-regulates HO-1 via Bach1 and Nrf2 in human liver cells...
  57. doi Activation of transcription factor Nrf2 by hepatitis C virus induces the cell-survival pathway
    Dylan Burdette
    Department of Microbiology and Immunology, H M Bligh Cancer Research Laboratories, Rosalind Franklin University of Medicine and Science, Chicago Medical School, North Chicago, IL 60064, USA
    J Gen Virol 91:681-90. 2010
    ..The transcription factor Nrf2 is known to be activated in response to oxidative stress, but the mechanism of its activation is not clearly ..
  58. pmc Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene
    Y Wang
    The Johns Hopkins Oncology Center, Bunting Blaustein Cancer Research Building, Room 551, 1650 Orleans Street, Baltimore, MD 21231, U S A
    Biochem J 355:45-9. 2001
    ..Mutations that interrupt either the leucine zipper of Nrf-2 or the coiled-coil region of PMF-1 are demonstrated to alter the ability of these factors to interact, thus their ability to regulate the transcription of the SSAT gene is lost...
  59. ncbi Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate
    Mee Hyang Kweon
    Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 281:33761-72. 2006
    ..Because we found that A549 cells constitutively overexpress HO-1 and its associated transcription factor Nrf2, we tested an hypothesis that EGCG resistance in these cells may be linked with Nrf2-mediated HO-1 overexpression...
  60. pmc Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes
    Stuart A Rushworth
    School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, United Kingdom
    J Immunol 181:6730-7. 2008
    ..The transcription factor NF-E2-related factor 2 (Nrf2) regulates innate immune responses in various experimental disease models...
  61. pmc Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression
    Yanlin Wang
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Oncology Center, Bunting Blaustein Cancer Research Building, Room 551, 1650 Orleans Street, Baltimore, MD 21231, U S A
    Biochem J 366:79-86. 2002
    ..Since CSN 7 does not contain a DNA-binding domain, its effects on transcription must occur in conjunction with binding to other proteins. The results presented here demonstrate that PMF-1 and Nrf-2 can act as protein partners of CSN 7...
  62. doi Erythropoietin induces nuclear translocation of Nrf2 and heme oxygenase-1 expression in SH-SY5Y cells
    Kursad Genc
    Health Sciences Institute, Dokuz Eylul University, Inciralti, Izmir, Turkey
    Cell Biochem Funct 28:197-201. 2010
    ..investigated whether Epo affects the transcription and activation of nuclear factor erythroid 2-related factor 2 (Nrf2), which is a key transcription factor of the cellular anti-oxidant defense system, and mRNA expression of its ..
  63. pmc Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils
    Rajesh K Thimmulappa
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Antioxid Redox Signal 9:1963-70. 2007
    Sepsis is characterized by an inappropriate host immune-inflammatory response and sustained oxidative damage. Nrf2, a bZIP oxidant-responsive transcription factor, regulates a battery of cytoprotective genes including antioxidants and ..
  64. ncbi Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells
    Tomonori Hosoya
    Environmental Response Project ERATO Japan Science and Technology Agency, Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, 305 8575, Japan
    J Biol Chem 280:27244-50. 2005
    The Nrf2-Keap1 system coordinately regulates cytoprotective gene expression via the antioxidant responsive element (ARE)...
  65. ncbi Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells
    Richard M Ogborne
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, CB1 9NL, UK
    Arterioscler Thromb Vasc Biol 25:2100-5. 2005
    ..This study examined the effects of ALA on HO-1 expression in human monocytic cells...
  66. pmc BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress
    Jianyong Zhang
    Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305 8577, Japan
    Mol Cell Biol 26:7942-52. 2006
    NF-E2-related factor 2 (Nrf2) regulates antioxidant-responsive element-mediated induction of cytoprotective genes in response to oxidative stress...
  67. pmc Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif
    Wenge Li
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Biochim Biophys Acta 1783:1847-56. 2008
    b>Nrf2 is the key transcription factor regulating the antioxidant response. When exposed to oxidative stress, Nrf2 translocates to cell nucleus and forms heterodimer with small Maf proteins (sMaf)...
  68. ncbi Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes
    R Venugopal
    Department of Pharmacology, Baylor College of Medicine, Texas 77030 3498, USA
    Oncogene 17:3145-56. 1998
    ..In the present report, we demonstrate that nuclear transcription factors Nrf2 and Nrf1 associate with Jun (c-Jun, Jun-B and Jun-D) proteins to upregulate ARE-mediated expression and coordinated ..
  69. ncbi Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK
    T Nguyen
    Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 275:15466-73. 2000
    ..Recent studies using knockout mice suggest that NF-E2-related factor 2 (Nrf2), along with small Maf proteins, binds and activates the ARE...
  70. pmc The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase
    Sara B Cullinan
    The Leonard and Madlyn Abramson Family Cancer Research Institute and Cancer Center, Department of Cancer Biology, University of Pennsylvania Cancer Center, 454 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Mol Cell Biol 24:8477-86. 2004
    The Nrf2 transcription factor promotes survival following cellular insults that trigger oxidative damage. Nrf2 activity is opposed by the BTB/POZ domain protein Keap1...
  71. ncbi Nuclear import and export signals in control of Nrf2
    Abhinav K Jain
    Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA
    J Biol Chem 280:29158-68. 2005
    b>Nrf2 binds to the antioxidant response element and regulates expression and antioxidant induction of a battery of chemopreventive genes...
  72. ncbi Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway
    Donna D Zhang
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
    J Biol Chem 280:30091-9. 2005
    ..Keap1 targets its substrate, the Nrf2 transcription factor, for ubiquitination and subsequent degradation by the 26 S proteasome...
  73. ncbi Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C
    Stuart A Rushworth
    Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, United Kingdom
    J Immunol 175:4408-15. 2005
    ..genes, contains antioxidant-response elements (AREs) that can bind the transcription factor NF-E2-related factor 2 (Nrf2). At present, the role of Nrf2 in LPS-induced HO-1 expression in monocytic cells has not been investigated...
  74. ncbi Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
    Balasundaram Padmanabhan
    RIKEN Genomic Sciences Center, Tsurumi, Yokohama 230 0045, Japan
    Mol Cell 21:689-700. 2006
    b>Nrf2 regulates the cellular oxidative stress response, whereas Keap1 represses Nrf2 through its molecular interaction...
  75. ncbi Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain
    Wenge Li
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 281:27251-63. 2006
    NF-E2-related factor 2 (Nrf2) is the key transcription factor regulating the antioxidant response...
  76. pmc Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2
    Zheng Sun
    Department of Pharmacology and Toxicology, University of Arizona, 1703 East Mabel Street, Tucson, AZ 85721, USA
    Mol Cell Biol 27:6334-49. 2007
    The transcription factor Nrf2 regulates cellular redox homeostasis. Under basal conditions, Keap1 recruits Nrf2 into the Cul3-containing E3 ubiquitin ligase complex for ubiquitin conjugation and subsequent proteasomal degradation...
  77. ncbi Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer
    Chi Chen Hong
    Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 16:1784-94. 2007
    ..Using unconditional logistic regression, genetic variations in Nrf2 (11108C>T), NQO1 (609C>T), NOS3 (894G>T), and HO-1 [(GT)(n) dinucleotide length polymorphism] were not ..
  78. ncbi Molecular basis distinguishing the DNA binding profile of Nrf2-Maf heterodimer from that of Maf homodimer
    Momoko Kimura
    Graduate School of Comprehensive Human Sciences and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8572, Japan
    J Biol Chem 282:33681-90. 2007
    b>Nrf2-small Maf heterodimer activates the transcription of many cytoprotective genes through the antioxidant response element and serves as a key factor in xenobiotic and oxidative stress responses...
  79. ncbi Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells
    Aruna Kode
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Box 850, 601 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 294:L478-88. 2008
    Nuclear erythroid-related factor 2 (Nrf2), a redox-sensitive transcription factor, is involved in transcriptional regulation of many antioxidant genes, including glutamate-cysteine ligase (GCL)...
  80. pmc Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1
    Deepti Malhotra
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Room E7624, 615 North Wolfe St, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 178:592-604. 2008
    ..b>NRF2, a redox-sensitive transcription factor, dissociates from its inhibitor, KEAP1, to induce antioxidant expression ..
  81. pmc Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response
    Zheng Sun
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, USA
    PLoS ONE 4:e6588. 2009
    The bZIP transcription factor Nrf2 has emerged as a pivotal regulator of intracellular redox homeostasis by controlling the expression of many endogenous antioxidants and phase II detoxification enzymes...
  82. pmc Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes
    Tomonaga Ichikawa
    Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, USA
    PLoS ONE 4:e8391. 2009
    Targeting Nrf2 signaling appears to be an attractive approach for the treatment of maladaptive cardiac remodeling and dysfunction; however, pharmacological modulation of the Nrf2 pathway in the cardiovascular system remains to be ..
  83. pmc The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy
    Tao Jiang
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona, USA
    Diabetes 59:850-60. 2010
    ..b>Nrf2 is the primary transcription factor that controls the antioxidant response essential for maintaining cellular redox ..
  84. pmc Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease
    Malin von Otter
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Bla Straket 15, 413 45 Gothenburg, Sweden
    BMC Med Genet 11:36. 2010
    ..Here, we hypothesize that variation in NFE2L2 and KEAP1, the genes encoding the two major regulators of the phase II response, may affect the risk of Parkinson'..
  85. pmc Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer
    Yuan Yao
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Breast Cancer Res Treat 124:585-91. 2010
    ..Induction of NF-E2-related factor 2 (NRF2)-dependent detoxifying enzymes (e.g...
  86. doi Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution
    Keiko Taguchi
    Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai 980 8575, Japan
    Genes Cells 16:123-40. 2011
    The Keap1–Nrf2 regulatory pathway plays a central role in the protection of cells against oxidative and xenobiotic damage...
  87. pmc PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function
    Jianglin Ma
    Department of Radiation Oncology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA
    Mol Cell Biol 32:1506-17. 2012
    ..with KEAP1, an oxidative stress sensor that binds and represses the master antioxidant transcription factor NRF2. PALB2 shares with NRF2 a highly conserved ETGE-type KEAP1 binding motif and can effectively compete with NRF2 for ..
  88. doi NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: implications for tumor growth retardation and docetaxel sensitivity
    Sarala Manandhar
    College of Pharmacy, Yeungnam University, Gyeongsangbuk do 712 749, Republic of Korea
    Free Radic Biol Med 52:1773-85. 2012
    NF-E2-related factor 2 (NRF2) is a transcription factor that regulates the expression of various antioxidant and detoxifying enzymes...
  89. pmc Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2)
    Wen Li
    Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China
    J Biol Chem 287:20922-30. 2012
    The Nrf2 (nuclear erythroid 2 p45-related factor-2) signaling pathway is known to play a pivotal role in a variety of oxidative stress-related human disorders...
  90. doi Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene
    Qiaoqiao Wang
    Department of Oncology, Department of Breast Surgery, Breast Cancer Institute, Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai 200032, China
    Acta Biochim Biophys Sin (Shanghai) 45:179-87. 2013
    ..The activity of BRCA1 promoter is regulated by transcriptional factors. The transcription factor Nrf2 (Nuclear factor-erythroid-2p45-related factor 2) is a potent transcriptional activator and plays a central role in ..
  91. pmc Regulation of Nrf2-an update
    Suryakant K Niture
    Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Free Radic Biol Med 66:36-44. 2014
    b>Nrf2:INrf2 (Keap1) are cellular sensors of oxidative and electrophilic stress...
  92. ncbi Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation
    C H He
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 276:20858-65. 2001
    b>Nrf2 regulates expression of genes encoding enzymes with antioxidant (e.g. heme oxygenase-1 (HO-1)) or xenobiotic detoxification (e.g...
  93. ncbi Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells
    R Tirumalai
    Department of Environmental Health Sciences, Division of Toxicological Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205 2179, USA
    Toxicol Lett 132:27-36. 2002
    ..Western blot analysis revealed the increased level of the transcription factor, Nrf2 in the nuclear extract from acrolein treated cells...
  94. ncbi Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
    H C Huang
    Schering Plough Research Institute, Kenilworth, New Jersey 07033, USA
    J Biol Chem 277:42769-74. 2002
    b>Nrf2, a basic leucine zipper transcription factor, is an essential activator of the coordinated transcription of genes encoding antioxidant enzymes and phase II detoxifying enzymes through the regulatory sequence termed antioxidant ..
  95. ncbi Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium
    Daniel Stewart
    Department of Molecular Genetics, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    J Biol Chem 278:2396-402. 2003
    b>Nrf2 mediates inducer-dependent activation of the heme oxygenase-1 (HO-1) gene (Alam, J., Stewart, D., Touchard, C., Boinapally, S., Choi, A. M., and Cook, J. L. (1999) J. Biol. Chem...
  96. ncbi Transcriptional regulation of the heme oxygenase-1 gene via the stress response element pathway
    J Alam
    Department of Molecular Genetics, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Curr Pharm Des 9:2499-511. 2003
    ..and to a lesser extent of the human gene, has identified a common mechanism the stress response element (StRE)/Nrf2 transcription factor pathway for gene regulation in response to a diverse array of HO-1 inducers including the ..
  97. ncbi Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein kinase cascades and synergistic stimulatory effect of Raf and CREB-binding protein
    Guoxiang Shen
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 279:23052-60. 2004
    Transcription factor NF-E2-related factor 2 (Nrf2) regulates the induction of Phase II detoxifying enzymes as well as anti-oxidative enzymes...
  98. ncbi Identification of polymorphisms in the promoter region of the human NRF2 gene
    Tae Yamamoto
    Graduate School of Comprehensive Human Sciences, Majors of Medical Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8577, Japan
    Biochem Biophys Res Commun 321:72-9. 2004
    Transcription factor Nrf2 regulates the basal and inducible expression of detoxifying and antioxidant genes. Recent studies using nrf2-null mice suggest that Nrf2 dysfunction might be involved in the pathogenesis of human diseases...
  99. ncbi Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells
    Jiang Li
    School of Pharmacy, University of Wisconsin at Madison, Madison, Wisconsin 53705, USA
    Toxicol Sci 83:313-28. 2005
    Recent studies indicate that NF-E2 related factor 2 (Nrf2) is a substrate for the ubiquitin-proteasome pathway...
  100. ncbi Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants
    Saravanakumar Dhakshinamoorthy
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 280:16891-900. 2005
    The antioxidant response element (ARE) and Nrf2 are known to regulate the expression and coordinated induction of genes encoding detoxifying enzymes including NAD(P)H:quinone oxidoreductase1 (NQO1) in response to antioxidants...
  101. ncbi Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif
    Wenge Li
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 280:28430-8. 2005
    Basic leucine zipper (bZIP) protein Nrf2 is a key transcription factor mediating the antioxidant response. Under homeostatic conditions Nrf2 is anchored to cysteine-rich Keap1 and sequestered in the cytoplasm...

Research Grants94

  1. Myocardial salvage via coordinated induction of endogenous cardiac antioxidants
    Yunbo Li; Fiscal Year: 2010
    ..Recently, Nrf2 is found to be a central regulator of cytoprotective gene expression in animal tissues, including liver and lung...
  2. Quercitrin functions as an antioxidant and protects UV-induced carcinogenesis
    Zhuo Zhang; Fiscal Year: 2012
    ..In addition, quercitrin stimulated the activation of NF-E2-related factor (Nrf2) and GST ARE- luciferase activity. Comet assays showed that quercitrin could block DNA damage induced by UVB...
  3. Role of Nrf2 signaling in modulating ethanol-induced teratogenesis
    Shao Yu Chen; Fiscal Year: 2012
    ..As a necessary prerequisite to reaching this goal, in this application, we propose to investigate the role of Nrf2 signaling in modulating ethanol-induced teratogenesis...
  4. Marta Margeta; Fiscal Year: 2015
    ..The specific objective of this application is to elucidate molecular mechanisms underlying synaptic function of Nrf2, the transcriptional regulator of inducible antioxidant response that is a key determinant of neuronal ..
  5. Enhancing Nrf2 by Sulforaphane Treatment in COPD
    Robert A Wise; Fiscal Year: 2012
    ..exposed to cigarette smoke have impairment of antioxidant defenses which are caused by a defect in activity of Nrf2, a prolific regulator of anti-oxidant enzymes, glutathione homeostasis, and cytoprotective proteins...
  6. Mustafa F Lokhandwala; Fiscal Year: 2016
    ..Conversely, redox sensitive transcription factor Nrf2 activates a highly regulated defense system against oxidative stress which involves transcriptional activation of ..
  7. Mechanisms of Embryo Response to Oxidative Stress
    Mark E Hahn; Fiscal Year: 2013
    ..In adult animals, oxidants initiate an anti-oxidant response by activating NF-E2-related factor 2 (NRF2) and related proteins, which bind to the anti-oxidant response element and activate transcription of genes such as ..
  8. Thu H Le; Fiscal Year: 2015
    ..We have identified the null variant of the GSTM1 gene, a member of the Nrf2 antioxidant pathway, as a modifier of hypertensive kidney disease progression...
  9. Novel strategy to mitigate and treat radiation combined infection injury by targe
    Shyam Biswal; Fiscal Year: 2012
    ..Our studies have shown that redox sensitive transcription factor, nuclear factor-erythroid 2 p45-related factor 2 (NRF2) protects against inflammatory disorders caused by environmental oxidants and bacterial infection by inhibiting ..
  10. Pulmonary effects of biomass fuel indoor PM from rural India
    Shyam Biswal; Fiscal Year: 2013
    ..hypothesis that antioxidants such as sulforaphane present in the diet can cause chemoprotection by activating the Nrf2 pathway to counteract oxidative stress and inflammation and protect against the pulmonary asthmatic response ..
  11. Ula V Jurkunas; Fiscal Year: 2016
    ..ARE), we investigated levels of the main ARE- binding transcription factor, nuclear factor-E2-related factor-2 (Nrf2). We detected a decrease in Nrf2 protein level in FECD endothelium...
  12. Regulation of the Expression of G[alpha]i2 by Reactive Oxygen Species
    Ifeanyi J Arinze; Fiscal Year: 2012
    ..To extend preliminary studies showing that G1i2 is up-regulated by ROS through the Nrf2/Keap1 pathway, a pathway that underlies cells'response to oxidative stress, two specific aims are proposed...
  13. Murugappan Ramanathan; Fiscal Year: 2015
    ..exposure (particulate matter and allergens) on oxidative stress based sinonasal inflammation regulated by the Nrf2 anti- oxidant pathway. Dr...
  14. SYLVAIN DORE; Fiscal Year: 2016
    ..prompted us to focus our attention on Korean Ginseng and test the hypothesis that the transcriptional factor Nrf2 could participate in the overall Ginseng's neuroprotective function...
  15. Antioxidant Defense Mechanisms: Nrf2/Keap1 Signaling in Aging Heart
    RAJASEKARAN NAMAKKAL SOORAPPAN; Fiscal Year: 2013
    ..findings indicate that exercise escalates antioxidant function through nuclear erythroid-2 p45 related factor-2 (Nrf2)...
  16. Paradoxical roles of Nrf2 activation in arsenic-induced beta-cell dysfunction
    Jingbo Pi; Fiscal Year: 2012
    ..cell dysfunction in diabetes, this project proposes that in response to arsenic exposure, transcription factor Nrf2-mediated adaptive induction of endogenous antioxidant enzymes plays paradoxical roles in ?-cell function...
  17. Zeljko Vujaskovic; Fiscal Year: 2016
    ..widely available medical countermeasure to mitigate and/or treat radiation-induced pulmonary injury by utilizing a Nrf2 activator, trifluoromethyl-2'-methoxychalone (TMC) developed at Johns Hopkins University (JHU)...
  18. SHELLY CHI LOO LU; Fiscal Year: 2016
    ..the expression of hepatic GSH synthetic enzymes is reduced markedly due to displacement of transcription factor Nrf2 by MafG and c-Maf from binding to the anti-oxidant response element (ARE) that is important in positive regulation ..
  19. ANIL KUMAR JAISWAL; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): INrf2:Nrf2 acts as a sensor for oxidative/electrophilic stress...
  20. Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
    Stuart A Lipton; Fiscal Year: 2013
    ..which crosses the blood-brain-barrier to exert effects by up-regulating endogenous anti-oxidant enzymes via the Nrf2 transcriptional pathway...
  21. Bhagavatula Moorthy; Fiscal Year: 2016
    ..in this application is that specific single nucleotide polymorphisms (SNPs) in the genes for NF-E2-related factor (Nrf2) and/or NADPH quinone reductase (NQO1) contribute to ALI/ARDS by attenuating the expression of pulmonary and ..
  22. Transcription Factor Cross-Talk in Developmental Toxicity
    LARISSA WILLIAMS; Fiscal Year: 2012
    ..transcription factors -- the aryl hydrocarbon receptor (AHR) and nuclear factor erythroid 2-related factor 2 (NRF2)...
  23. Cardiovascular Effects of Ultrafine Particles in Genetically Susceptible Subjects
    Mark W Frampton; Fiscal Year: 2010
    ..We will study 3 groups of 12 subjects each, with differing genotypes as follows: 1) GSTM1 null, 2) Nrf2 -617A/C, and 3) "wild type" for both genes (GSTM1+ and Nrf2 -617C/C)...
  24. BRIGID JENSEN; Fiscal Year: 2014
    ..b>Nrf2 is the transcription factor responsible for the EAR...
  25. DAVID MARSHALL GUIDOT; Fiscal Year: 2014
    ..Activation of the ARE is mediated by the nuclear transcription factor Nrf2, a zinc-finger protein that turns on a genetic program that stimulates the production of multiple anti-oxidants ..
  26. Yuqing Eugene Chen; Fiscal Year: 2014
    ..FA exerted anti-proliferative and pro-apoptotic effects in vascular smooth muscle cells (VSMC) via activation of Nrf2 with an increase in Nrf2 stability in vitro...
  27. Reactive Oxygen Species in Coronary Collateral Growth
    William M Chilian; Fiscal Year: 2013
    ..Determine the cell type where reducing oxidative stress by over expressing Nrf2 in the JCR rat (a model of reduced coronary collateral growth and oxidative stress) will restore collateral growth...
  28. Translational Control of Oxidative Stress in Myocardial Infarction
    Qin M Chen; Fiscal Year: 2010
    ..A master switch controlling the expression of these genes is the transcription factor Nrf2. We found that 2 to 4 cycles of 5 min ischemia and 5 min reperfusion cause elevation of Nrf2 protein in the ..
  29. EPIGENETIC AGING OF THE OXIDATIVE STRESS RESPONSE IN THE MOUSE RPE
    Zeljka Smit McBride; Fiscal Year: 2010
    ..The set includes Er1, Err1, Foxo3a, Nrf2, Pgc11, Prdx3, p66/Shc1, Sirt1, Sod2, Txn2, Txnrd2, and 14-3-38...
  30. Rodney W Johnson; Fiscal Year: 2015
    ..The specific hypothesis is that dysfunctional Nuclear factor E2-related factor 2 (Nrf2) signaling is responsible for microglial cell priming and increased basal inflammation in the senescent brain and ..
  31. Antioxidant activities of freeze dried acai berry (Euterpe Oleracea)extracts
    Gregory M Raner; Fiscal Year: 2013
    ..that initiate production of reactive chemical species, including reactive oxygen species (ROS), and (2) induce the Nrf2-dependent transcriptional pathway, activating an entire battery of anti-oxidant genes...
  32. Therapeutic potential of ARE-mediated gene expression in Huntington's disease
    KARI RENE HOYT; Fiscal Year: 2010
    ..To this end, we have generated a novel transgenic mouse strain where the are transcription factors Nrf2 and MafK are driven in a tetracycline-inducible manner within forebrain neurons or glia...
  33. Heinrich Jasper; Fiscal Year: 2015
    ..The preliminary data on which this proposal is based indicate a key role of the Nrf2 transcription factor, which has previously been mostly associated with antioxidant and detoxification programs...
  34. Samina Salim; Fiscal Year: 2015
    ..oxidative stress, involvement of PKC, p38 and calpain pathways as well as involvement of transcription factors (Nrf2, Sp-1) in an RGS2 dependent regulation of Glo1 and Gsr1 levels will be studied...
  35. Mechanisms that Regulate Neonatal Lung Heme Oxygenase in Hyperoxia
    Phyllis A Dennery; Fiscal Year: 2013
    ..the regulation of genes with antioxidant response elements (ARE) through pathways involving p38 MAP kinase and NrF2. Overall, the predominance of nuclear or cytoplasmic forms of HO-1 could greatly alter the response to an oxidative ..
  36. Ozone Cardiovascular Effects in Genetically Susceptible People
    MARK WALTER FRAMPTON; Fiscal Year: 2012
    ..conferring reduced function in glutathione transferase M1 (GSTM1) or nuclear factor erythroid 2- related factor 2 (Nrf2), key regulators of antioxidant defenses, will show increased susceptibility...
  37. Development of small molecules targeting Nrf2 pathway for treatment of Colitis
    Graham P Allaway; Fiscal Year: 2013
    ..The transcription factor Nrf2 has emerged as a central player in regulating antioxidant defenses and innate immune response...
  38. Raghu Vemuganti; Fiscal Year: 2014
    ..NOX2 and thus curtails reactive oxygen species (ROS) formation, and TBHQ that potentiates the transcription factor Nrf2 which is upstream to many antioxidant genes and thus efficiently neutralizes ROS...
  39. Scott M Plafker; Fiscal Year: 2015
    ..Paramount among these protective proteins is Nrf2, the master anti-oxidant transcription factor...
  40. Michelle Hernandez; Fiscal Year: 2014
    ..antioxidant enzymes (NQO1, GSTP1, HO-1) are regulated by the master transcription factor NF-E2- related factor 2 (NRF2)...
  41. Redox Mechanisms of Chemoprevention in Lung by Selenium Supplementation
    ROBYN POERSCHKE; Fiscal Year: 2010
    ..lung cancer, we propose to test the hypothesis that distinct selenocompounds alter redox status, with ARE/Nrf2 activation and TrxRI and GPx2 playing a role in redox modulation with the following aims: Aim 1: Determine the ..
  42. Shuji Kishi; Fiscal Year: 2014
    ..antioxidant response regulatory element (ARE) through binding of the transcription factor NF-E2-related factor 2 (Nrf2)...
  43. Nrf2 as a Master Regulator in Liver Disease Prevention and Therapy
    Curtis D Klaassen; Fiscal Year: 2012
    ..Nuclear factor 2-related factor 2 (Nrf2), a transcription factor expressed in both hepatocytes and immune cells, is a key factor in anti-oxidative and anti-..
  44. Frank R Sharp; Fiscal Year: 2016
    ..factors, there is a potential for therapeutic intervention Recent studies of mutant mice show that knockout of the Nrf2 (Nuclear factor erythroid-derived 2-like 2) gene results in loss of brain myelin with a vacuolar ..
  45. Jerzy W Kupiec-Weglinski; Fiscal Year: 2016
    ..Our corollary hypothesis states that Nrf2, a bZIP transcriptional factor that regulates stress response/regulates cell redox balance, controls dysregulated ..
  46. Homogenous HTS Assays to Screen for Inhibitors of Keap1-Nrf2 Interaction
    Longqin Hu; Fiscal Year: 2010
    Keap1-Nrf2-antioxidant response element (ARE) system regulates cellular defense mechanisms that protect cells from oxidative stress...
  47. Jefferson Y Chan; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Nrf1 and Nrf2 are members of the CNC family of bZIP transcription factors that exhibit structural similarities, and both are expressed in a wide range of tissues...
  48. Yongke Lu; Fiscal Year: 2014
    ..We hypothesize that CYP2E1-mediated ROS activates redox sensitive nuclear factor-eythroid 2-related factor 2 (Nrf2), and Nrf2 upregulates CYP2A5, which may metabolize ethanol and increase oxidative stress which contributes to ..
  49. Antioxidants and Antiinflammatory in Colorectal Cancer
    Ah Ng Tony Kong; Fiscal Year: 2012
    ..In addition, we obtained preliminary data that using the Nrf2-/- mice, of which Nrf2 is known to be a transcriptional factor that plays critical role in cytoprotection against ..
  50. Michael Aschner; Fiscal Year: 2016
    ..We hypothesize that under conditions of MeHg-induced oxidative stress, Nrf2 coordinates the upregulation of cytoprotective genes that combat MeHg- induced oxidative injury, and that genetic ..
  51. Nrf2 Protein Translation in Oxidative Stress
    Qin M Chen; Fiscal Year: 2010
    ..switch controlling the expression of Phase II antioxidant and detoxification enzymes is the transcription factor Nrf2. We found that oxidants cause rapid translation of endogenous Nrf2 protein...
  52. Autophagy, p62 and the Nrf2 Intersect to Protect Against Tau Toxicity
    Gail V W Johnson; Fiscal Year: 2013
    ..proposal is on determining the role of autophagy in the selective clearance of pathological tau and the role of the Nrf2 pathway in regulating this process...
  53. Paradoxical Roles of Reactive Oxygen Species in Pancreatic Beta-Cell Function
    Jingbo Pi; Fiscal Year: 2009
    ..to modulate insulin secretion;(ii) Test the hypothesis that antioxidant response mediated by transcription factor Nrf2 enhances cellular ROS scavenging activity and thus negatively regulates GSIS...
  54. SOLOMON FIIFI OFORI-ACQUAH; Fiscal Year: 2016
    ..NQO1 expression is regulated by the redox-sensitive transcription factor NF-E2 related factor 2 (Nrf2)...
  55. Developing Nrf2 as a target for treatment of corticosteroid resistance in COPD
    Robert A Wise; Fiscal Year: 2012
    ..Nuclear factor erythroid 2-related factor 2 (Nrf2) a bZIP transcription factor, protects from oxidative stress by upregulating a robust cytoprotective response that ..
  56. Pleiotropic Transcription Factors As Target For Intracerebral Hemorrhage Treatmen
    Jaroslaw A Aronowski; Fiscal Year: 2012
    ..Here, we propose that nuclear factor-erythroid E2-related factor 2 (Nrf2), a pleiotropic protein that regulates transcription of a battery of key cytoprotective, detoxifying, and ..
  57. KATHARINE LIANG; Fiscal Year: 2015
    ..These experiments will be conducted using a Nrf2-deficient mouse that exhibits an age-related retinopathy similar to AMD in humans...
  58. Shyam Biswal; Fiscal Year: 2014
    ..Nuclear factor erythroid-2 related factor-2 (Nrf2) is a redox-sensitive transcription factor that regulates the expression of electrophile/ xenobiotic detoxification ..
  59. Ah Ng Tony Kong; Fiscal Year: 2015
    ..that: (i) As TRAMP PCa progresses, there is a progressive loss of the anti-oxidative stress transcription factor Nrf2 and Nrf2-target genes phase II detoxifying and antioxidant enzymes;(ii) Treatment with PEITC resulted in the re-..
  60. Human NRF2 Promoter Functional Polymorphisms and Acute Lung Injury
    Sekhar P Reddy; Fiscal Year: 2012
    ..Through a genetic linkage analysis, we have first identified Nrf2 transcription factor as an important candidate gene that regulates hyperoxic lung injury (HLI)...
  61. Ah Ng Tony Kong; Fiscal Year: 2015
    ..effect of ?-TmT on the formation and growth of LNCaP tumors in the SCID mice;(iii) IHC of re-expression of Nrf2 and anti-oxidative stress/antioxidant genes in ?-TmT-treated TRAMP prostate tumors;(iv) Induction of Nrf2-ARE-..
  62. James T Handa; Fiscal Year: 2016
    ..Nuclear factor- erythroid 2-related factor 2 (Nrf2), a basic leucine zipper redox-sensitive transcription factor, regulates the inducible expression of antioxidant ..
  63. Donna D Zhang; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): The transcription factor Nrf2 has emerged as a master regulator of a cellular protective mechanism by upregulating antioxidant response element (ARE)-bearing genes encoding antioxidant enzymes, ..
  64. Prevention of oxidative stress decreases persistence of drug tolerant M. Tubercu
    Randall J Basaraba; Fiscal Year: 2010
    ..therapeutically the antioxidant defenses regulated by the host transcription factor nuclear redox factor2 (Nrf2) in Mtb-infected guinea pigs, conventional anti-tuberculosis drug therapy will be more effective against persistent,..
  65. Jonathan S Weissman; Fiscal Year: 2016
    ..The gene hits include known C. elegans FOXO regulators, regulators of other longevity proteins such as TOR and NRF2, and new genes as well...
  66. RAJASEKARAN NAMAKKAL SOORAPPAN; Fiscal Year: 2016
    ..We now demonstrate that constitutive activation of nuclear erythroid-2 like factor-2 (Nrf2) signaling is a potential mechanism for Reductive Stress (RS) and PAC in these pathogenic processes...
  67. Ah Ng Tony Kong; Fiscal Year: 2016
    ..NFkB;an analog of CUR dibenzoylmethane, inhibits adenomas in APCmin mice, and CRC in AOM-DSS mice;(3) CUR regulate Nrf2-dependent genes in the intestine using Nrf2 KO mice;(4) As TRAMP mouse PCa progresses, there is a loss of the anti-..
  68. ZOLTAN ISTVAN UNGVARI; Fiscal Year: 2014
    ..NF-E2-related factor 2 (Nrf2) is a transcription factor, that regulates the expression of numerous ROS detoxifying and antioxidant genes...
  69. Gregory M Vercellotti; Fiscal Year: 2015
    ..Determine whether upregulation of Nrf2, a transcriptional regulator of anti-oxidant defenses, will induce proteins that remove and detoxify heme and ..
  70. Srinivasan V Narayanan; Fiscal Year: 2014
    ..Nuclear factor erythoid-2 related factor (Nrf2) is a transcriptin factor involved in protecting the cell from the damaging effects of oxidative stress...
  71. Zhen Jane Wang; Fiscal Year: 2016
    ..response to an angiotensin converting enzyme inhibitor (Ramipril), a nuclear factor erythroid 2-related factor 2 (Nrf2) pathway activator (Sulforaphane), and a transketolase activator (Thiamine) using the HP probes, with particular ..
  72. Viranuj Sueblinvong; Fiscal Year: 2016
    ..We have novel evidence that this pathophysiological sequence begins with a dampening of signaling by Nrf2, the transcription factor required to activate the anti-oxidant response element (ARE)...
  73. WALLACE SIU HUNG CHICK; Fiscal Year: 2016
    ..for multi-stress resistance, levels of reactive oxygen species under stress, pluripotency, expression levels of Nrf2 and other antioxidant genes, and their capability of maintaining stress-resistance after differentiation into other ..
  74. Steven S An; Fiscal Year: 2015
    ..In support of this paradigm, we have demonstrated that mice, with a deletion of a transcription factor (Nrf2) that regulates several antioxidant genes, are more susceptible to oxidative stress and airway hyperresponsiveness, ..
  75. Jian Wang; Fiscal Year: 2016
    ..demonstrated that the flavanol (-)-epicatechin given orally reduces ischemic stroke damage through activation of Nrf2, a transcription factor that regulates the expression of endogenous antioxidant enzymes in the brain...
  76. Serrine S Lau; Fiscal Year: 2014
    ..Furthermore, at this therapeutic dose, aTRA induces Nrf2-responsive antioxidant HO-1 and NQO1 genes, as well as nuclear retinoic acid receptors RAR?, RAR?2, RAR?2, and ..
  77. Pharmacokinetic and Pharmacogenomic Determinants of Cisplatin Kidney Injury
    Melanie S Joy; Fiscal Year: 2013
    ..g. GSTP1 and GSTA1, and g-glutamyl transferase1, e.g. GGT1), and the NRF2/NFE2L2 transcription factor are important determinants of cisplatin exposure and nephrotoxicity...
  78. Brian M Polster; Fiscal Year: 2016
    ..We predict that drugs that induce the Nrf2/antioxidant response element pathway will potently synergize with idebenone by 1) upregulating NQO1 and by 2) ..
  79. Dennis B Lubahn; Fiscal Year: 2014
    ..The 5 key pathways to be examined are the (anti)oxidant (Nrf2/Keap1 and NADPH oxidase) pathways and their interactions with the NF-kappaB-, estrogen-, and hedgehog-signaling ..
  80. JEFFREY W HARPER; Fiscal Year: 2016
    ..and physiological pathways with an initial focus on a BACH1, a signal-dependent transcriptional repressor of NRF2-dependent genes and a novel substrate of SCFFBXL17 discovered via our proteomics platform...
  81. Activation of the Cancer Preventive Nrf2-ARE Pathway by Seaweed
    Hendrik Luesch; Fiscal Year: 2009
    ..enzymes are commonly regulated by the antioxidant response element (ARE) which is activated by transcription factor Nrf2. The activation of the Nrf2-ARE pathway is a valid cancer preventive strategy, and sulforaphane, a constituent of ..
  82. Investigating Nrf2 Phosphorylation in the Mechanism of Cancer Prevention Agents
    AIMEE EGGLER; Fiscal Year: 2009
    Many chemopreventive agents activate the Nrf2 transcription factor, leading to upregulation of cytoprotective enzymes and Nrf2-dependent protection against tumorigenesis...
  83. 3D Skin Model to Test Toxic and Sensitizing Potentials of Environmental Chemicals
    Akira Takashima; Fiscal Year: 2010
    ..will construct a KC biosensor clone by engineering the Pam 212 KC line to express the GFP gene under the control of Nrf2 (a transcription factor capable of triggering the Keep1-Nrf2-ARE cell survival response to environmental stresses)...
  84. Role of Nrf2 during cholestsis and gallstone formation
    ANGELA SLITT; Fiscal Year: 2009
    ..broad objective of this proposal is to understand how the transcription factor Nuclear Factor-E2-related factor 2 (Nrf2) regulates cholesterol and bile acid metabolism and disposition during cholestasis and during exposure to a high ..
  85. Molecular mechanisms of cytochrome P4501A regulation by hyperoxia
    Bhagavatula Moorthy; Fiscal Year: 2010
    ..2. To test the hypothesis that mice lacking the gene encoding AHR, nrf2 or NQO1 will be more susceptible to hyperoxic lung injury, and that these mice will be rescued by pre-treatment ..
  86. The Unfolded Protein Response in Human Airway and Alveolar Epithelial Cells
    Salim Merali; Fiscal Year: 2010
    ..stress termed the unfolded protein response (UPR) and that the UPR-related transcription factors, ATF-4 and Nrf2, proteins which regulate anti-oxidant gene expression, are up-regulated by CS in cultured airway epithelial cells...
  87. The Unfolded Protein Response in Subjects with COPD
    Steven Kelsen; Fiscal Year: 2009
    ..kinase) and its signaling pathway which up-regulates expression of the master anti-oxidant transcription factors, Nrf2 and ATF-4...
  88. Renal salvage via Nrf2-dependent antioxidative/anti-inflammatory enzymes
    Hong Zhu; Fiscal Year: 2009
    ..Recently, NF-E2-related factor 2 (Nrf2) has been found to be a critical transcription factor in regulation of antioxidative/anti-inflammatory gene ..
  89. BIOCHEMISTY OF HYPERTHERMIC CELLULAR INACTIVATION
    Michael Freeman; Fiscal Year: 2005
    ..Degradation of these proteins by the proteasome can result in accumulation of Nrf2; a transcription factor that regulates the GLCLC antioxidant element, ARE4 and which apparently undergoes ubiquitin ..