NFE2L1

Summary

Gene Symbol: NFE2L1
Description: nuclear factor, erythroid 2 like 1
Alias: LCR-F1, NRF1, TCF11, nuclear factor erythroid 2-related factor 1, NF-E2-related factor 1, NFE2-related factor 1, TCF-11, locus control region-factor 1, nuclear factor, erythroid derived 2, like 1, transcription factor 11 (basic leucine zipper type), transcription factor HBZ17, transcription factor LCR-F1
Species: human

Top Publications

  1. pmc Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast
    J Y Chan
    Department of Laboratory Medicine, University of California, San Francisco 94143 0724
    Proc Natl Acad Sci U S A 90:11371-5. 1993
  2. pmc Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice
    J Y Chan
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    EMBO J 17:1779-87. 1998
  3. ncbi Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function
    Weiping Wang
    Department of Laboratory Medicine and Pathology, University of California, Irvine, California 92697, USA
    J Biol Chem 281:19676-87. 2006
  4. ncbi The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription
    Weiping Wang
    Department of Pathology, University of California, Irvine, Irvine, California 92697, USA
    J Biol Chem 282:24670-8. 2007
  5. pmc Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells
    Senthil K Radhakrishnan
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Mol Cell 38:17-28. 2010
  6. doi Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop
    Janos Steffen
    Institut für Biochemie CC2, Charite Universitatsmedizin Berlin, Oudenarder Strasse 16, 13347 Berlin, Germany
    Mol Cell 40:147-58. 2010
  7. pmc Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration
    Candy S Lee
    Department of Laboratory Medicine and Pathology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 108:8408-13. 2011
  8. doi A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells
    James M McKim
    CeeTox Inc, Kalamazoo, Michigan 49008, USA
    Cutan Ocul Toxicol 29:171-92. 2010
  9. ncbi R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes
    W Shen
    Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Diabetologia 51:165-74. 2008
  10. pmc Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1
    Heping Yang
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Keck School of Medicine USC, Los Angeles, California 90033, USA
    Mol Cell Biol 25:5933-46. 2005

Research Grants

  1. GLOBIN GENE EXPRESSION DURING DEVELOPMENT
    Tim Townes; Fiscal Year: 2002
  2. NRF1 IN OXIDATIVE STRESS
    Jefferson Chan; Fiscal Year: 2003
  3. UBALDO EMILIO MARTINEZ OUTSCHOORN; Fiscal Year: 2016
  4. Nisha Jain Garg; Fiscal Year: 2016
  5. David A Sinclair; Fiscal Year: 2016
  6. Subburaman Mohan; Fiscal Year: 2015
  7. Claude A Piantadosi; Fiscal Year: 2016
  8. REGULATION OF CYCLIN D1 EXPRESSION
    Richard G Pestell; Fiscal Year: 2010
  9. MATTHEW THOMAS HURD; Fiscal Year: 2014
  10. THOMAS K BLACKWELL; Fiscal Year: 2015

Detail Information

Publications277 found, 100 shown here

  1. pmc Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast
    J Y Chan
    Department of Laboratory Medicine, University of California, San Francisco 94143 0724
    Proc Natl Acad Sci U S A 90:11371-5. 1993
    ..activators and have used it to identify a human basic leucine-zipper transcription factor that we have designated Nrf1 for NF-E2-related factor 1...
  2. pmc Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice
    J Y Chan
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    EMBO J 17:1779-87. 1998
    ..To determine the function of Nrf-1, targeted disruption of the Nrf-1 gene was carried out. Homozygous Nrf-1 mutant mice are anemic due to a non-cell autonomous defect in definitive erythropoiesis and die in utero...
  3. ncbi Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function
    Weiping Wang
    Department of Laboratory Medicine and Pathology, University of California, Irvine, California 92697, USA
    J Biol Chem 281:19676-87. 2006
    ..response elements involves members of the CNC (Cap 'n' Collar) family of basic leucine zipper proteins including Nrf1 and Nrf2. Nrf2 activity is regulated by Keap1-mediated compartmentalization in the cell...
  4. ncbi The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription
    Weiping Wang
    Department of Pathology, University of California, Irvine, Irvine, California 92697, USA
    J Biol Chem 282:24670-8. 2007
    ..Activation through the ARE involves members of the CNC-subfamily of basic leucine zipper proteins including Nrf1 and Nrf2...
  5. pmc Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells
    Senthil K Radhakrishnan
    Division of Biology, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA
    Mol Cell 38:17-28. 2010
    ..Here, we report that nuclear factor erythroid-derived 2-related factor 1 (Nrf1), a transcription factor of the cap "n" collar basic leucine zipper family, but not the related Nrf2, is necessary ..
  6. doi Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop
    Janos Steffen
    Institut für Biochemie CC2, Charite Universitatsmedizin Berlin, Oudenarder Strasse 16, 13347 Berlin, Germany
    Mol Cell 40:147-58. 2010
    ..Here, we report the identification of the transcription factor TCF11 (long isoform of Nrf1) as a key regulator for 26S proteasome formation in human cells to compensate for reduced ..
  7. pmc Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration
    Candy S Lee
    Department of Laboratory Medicine and Pathology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 108:8408-13. 2011
    ..Nuclear factor E2-related factor 1 (Nrf1) transcription factor has been shown to regulate expression of antioxidant and cytoprotective genes...
  8. doi A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells
    James M McKim
    CeeTox Inc, Kalamazoo, Michigan 49008, USA
    Cutan Ocul Toxicol 29:171-92. 2010
    ..Three signaling pathways (Keap1/Nrf 2/ARE/EpRE, ARNT/AhR/XRE, and Nrf1/MTF/MRE) that are known to be activated by sensitizing agents were monitored by measuring the relative abundance of ..
  9. ncbi R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes
    W Shen
    Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Diabetologia 51:165-74. 2008
    ..We examined the effect of two mitochondrial nutrients, R-alpha-lipoic acid (LA) and acetyl-L-carnitine (ALC), as well as their combined effect, on mitochondrial biogenesis in 3T3-L1 adipocytes...
  10. pmc Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1
    Heping Yang
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Keck School of Medicine USC, Los Angeles, California 90033, USA
    Mol Cell Biol 25:5933-46. 2005
    Glutamate-cysteine ligase catalytic subunit (GCLC) is regulated transcriptionally by Nrf1 and Nrf2. tert-Butylhydroquinone (TBH) induces human GCLC via Nrf2-mediated trans activation of the antioxidant-responsive element (ARE)...
  11. ncbi A new activating role for CO in cardiac mitochondrial biogenesis
    Hagit B Suliman
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Sci 120:299-308. 2007
    ..Mitochondrial biogenesis is activated by gene and protein expression of the nuclear respiratory factor 1 (NRF1) and NRF2, of peroxisome proliferator-activated receptor gamma co-activator-1alpha, and of mitochondrial ..
  12. ncbi hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2
    M G Marini
    Istituto di Clinica e Biologia dell Età Evolutiva, Universita di Cagliari, Cagliari 09121, Italy
    J Biol Chem 272:16490-7. 1997
    ..addition to homodimers, hMAF can also form high affinity heterodimers with two members of the NFE2/CNC-bZip family (Nrf1 and Nrf2) but not with a third family member, p45-NFE2...
  13. pmc NOS isoform-specific regulation of basal but not exercise-induced mitochondrial biogenesis in mouse skeletal muscle
    G D Wadley
    Department of Physiology, University of Melbourne, Parkville, Victoria, 3010, Australia
    J Physiol 585:253-62. 2007
    ..The basal mitochondrial biogenesis markers NRF1, NRF2alpha and mtTFA mRNA were significantly (P< 0...
  14. doi Interferon-stimulated gene ISG12b1 inhibits adipogenic differentiation and mitochondrial biogenesis in 3T3-L1 cells
    Bing Li
    Department of Animal Sciences, The Ohio State University, Columbus, Ohio 43210, USA
    Endocrinology 150:1217-24. 2009
    ..DNA content and gene expression of mitochondrial transcription factor A (mtTFA), nuclear respiratory factor 1 (NRF1), and cytochrome oxidase II, suggesting an inhibitory role of ISG12b1 in mitochondrial biogenesis and function...
  15. pmc Distinct Nrf1/2-independent mechanisms mediate As 3+-induced glutamate-cysteine ligase subunit gene expression in murine hepatocytes
    James A Thompson
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Free Radic Biol Med 46:1614-25. 2009
    ..of Gclc and Gclm was also differentially regulated by the MAPK signaling pathways and occurred independent of the Nrf1/2 transcription factors...
  16. pmc Regionalized pathology correlates with augmentation of mtDNA copy numbers in a patient with myoclonic epilepsy with ragged-red fibers (MERRF-syndrome)
    Anja Brinckmann
    Department of Neuropediatrics, Charite University Medical School, Berlin, Germany
    PLoS ONE 5:e13513. 2010
    ..we further determined the quantity of mitochondrial proteins (COX subunits II and IV), transcription factors (NRF1 and TFAM), and VDAC1 (Porin) as a marker for the mitochondrial mass...
  17. ncbi Thioredoxin1 upregulates mitochondrial proteins related to oxidative phosphorylation and TCA cycle in the heart
    Tetsuro Ago
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, UMDNJ, New Jersey Medical School, Newark, 07103, USA
    Antioxid Redox Signal 8:1635-50. 2006
    ..analysis showed that upregulated genes frequently contained binding sites for nuclear respiratory factor 1 (NRF1)...
  18. pmc Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis
    Josep A Villena
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:1418-23. 2007
    ..important for mitochondrial function, parallel to other factors controlling mitochondrial gene expression, such as NRF1 and NRF2/GABPA...
  19. doi Nrf3-deficient mice are not protected against acute lung and adipose tissue damages induced by butylated hydroxytoluene
    Gregory Chevillard
    Lady Davis Institute for Medical Research, Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    FEBS Lett 584:923-8. 2010
    ..In the lung, transcript levels of the transcription factors Nrf1, Nrf2 and Nrf3 were differentially regulated by BHT treatment...
  20. pmc Nrf1 is critical for redox balance and survival of liver cells during development
    Linyun Chen
    Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    Mol Cell Biol 23:4673-86. 2003
    The Nrf1 transcription factor belongs to the CNC subfamily of basic leucine zipper proteins. Knockout of Nrf1 is lethal in mouse embryos, but nothing is known about the cell types that absolutely require its function during development...
  21. ncbi Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress
    Laura Leung
    Department of Pathology, University of California, Irvine, Irvine, California 92697, USA
    J Biol Chem 278:48021-9. 2003
    b>Nrf1 and Nrf2 are members of the CNC family of bZIP transcription factors that exhibit structural similarities, and they are co-expressed in a wide range of tissues during development...
  22. pmc MCRS2 represses the transactivation activities of Nrf1
    Jia Long Wu
    IBMS, Academia Sinica, Taipei 11529, Taiwan, ROC
    BMC Cell Biol 10:9. 2009
    b>Nrf1 [p45 nuclear factor-erythroid 2 (p45 NF-E2)-related factor 1], a member of the CNC-bZIP (CNC basic region leucine zipper) family, is known to be a transcriptional activator by dimerization with distinct partners, such as Maf, FosB, c-..
  23. doi Prolonged Nrf1 overexpression triggers adipocyte inflammation and insulin resistance
    Florence H van Tienen
    Department of Genetics and Cell Biology, Maastricht University, Maastricht, The Netherlands
    J Cell Biochem 111:1575-85. 2010
    ..Although Pgc1α is regarded as the main regulator of mitochondrial function, downstream Nrf1 is the key regulator of mitochondrial biogenesis...
  24. pmc Nuclear respiratory factor 1 controls myocyte enhancer factor 2A transcription to provide a mechanism for coordinate expression of respiratory chain subunits
    Bindu Ramachandran
    Diabetes Research Laboratory, Department of Medicine, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 283:11935-46. 2008
    Nuclear respiratory factors NRF1 and NRF2 regulate the expression of nuclear genes encoding heme biosynthetic enzymes, proteins required for mitochondrial genome transcription and protein import, and numerous respiratory chain subunits...
  25. ncbi Isolation of a bi-directional promoter directing expression of the mouse GABPalpha and ATP synthase coupling factor 6 genes
    Y Chinenov
    Department of Biochemistry, University of Missouri at Columbia, MO, Columbia 65212, USA
    Gene 261:311-20. 2000
    ..cDNA sequence including sites for GABP (-86, -104, -169, -257, and -994), YY1 (-57), Sp1 (-242 and -226), and NRF1 (-5). No 'TATA' motif was identified near either the GABPalpha or ATPsynCF6 transcription start sites...
  26. ncbi Expression of transcription factors during megakaryocytic differentiation of CD34+ cells from human cord blood induced by thrombopoietin
    K Terui
    Department of Pediatrics, Hirosaki University School of Medicine, Japan
    Tohoku J Exp Med 192:259-73. 2000
    ..GATA-1 and GATA-2, a GATA-binding factor, EVI-1, the large subunit of NF-E2 factor, p45 and the related factors, Nrf1, Nrf2, Nrf3, BACH1, BACH2, and the small subunit of NF-E2, MAFK and MAFG has been examined in human megakaryocytic ..
  27. ncbi A common set of gene regulatory networks links metabolism and growth inhibition
    Hugh Cam
    Department of Pathology, MSB 504, New York University School of Medicine and New York University Cancer Institute, 550 First Avenue, New York, NY 10016, USA
    Mol Cell 16:399-411. 2004
    ..Motif-finding algorithms predicted the existence of nuclear respiratory factor-1 (NRF1) binding sites in E2F target promoters, and genome-wide factor binding analysis confirmed our predictions...
  28. ncbi In vivo, nucleoside reverse-transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes in the absence of depletion of mitochondrial DNA
    Patrick W G Mallon
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, NSW 2010, Australia
    J Infect Dis 191:1686-96. 2005
    ..The effects of this mitochondrial dysfunction on lipid metabolism, at a molecular level in vivo, have not been described...
  29. pmc Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes
    Kyle J Gaulton
    Department of Genetics, University of North Carolina at Chapel Hill, North Carolina, USA
    Diabetes 57:3136-44. 2008
    ..We used a candidate gene-based approach to identify single nucleotide polymorphism (SNP) variants in 222 candidate genes that influence susceptibility to type 2 diabetes...
  30. pmc Metabolic network topology reveals transcriptional regulatory signatures of type 2 diabetes
    Aleksej Zelezniak
    Department of Systems Biology, Technical University of Denmark, Center for Microbial Biotechnology, Lyngby, Denmark
    PLoS Comput Biol 6:e1000729. 2010
    ..The identified transcription factors include members of the CREB, NRF1 and PPAR family, among others, and represent regulatory targets for further experimental analysis...
  31. doi Association between polymorphisms in RAPGEF1, TP53, NRF1 and type 2 diabetes in Chinese Han population
    Lili Qu
    Central Laboratory of Nanjing First Hospital affiliated to Nanjing Medical University, 68 Changle Road, Nanjing, Jiangsu, China
    Diabetes Res Clin Pract 91:171-6. 2011
    ..The aim of the present study was to investigate the association between the polymorphisms of RAPGEF1, TP53 and NRF1 and the risk of type 2 diabetes in the Chinese Han population...
  32. pmc Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms
    Yoshiki Tsuchiya
    Laboratory for Genetic Cord, Graduate School of Life and Medical Sciences, Doshisha University, 1 3 Tatara Miyakodani, Kyotanabe 610 0394, Japan
    Mol Cell Biol 31:4500-12. 2011
    A growing body of evidence suggests that Nrf1 is an inducible transcription factor that maintains cellular homeostasis...
  33. doi An overview of transcriptional regulation in response to toxicological insult
    Paul Jennings
    Division of Physiology, Department of Physiology and Medical Physics, Innsbruck Medical University, Fritz Pregl Strasse 3 1, 6020 Innsbruck, Austria
    Arch Toxicol 87:49-72. 2013
    ..Primary among the response pathways involved are NFE2L2 (Nrf2), NFE2L1 (Nrf1), p53, heat shock factor and the unfolded protein response...
  34. pmc Natural antioxidants exhibit chemopreventive characteristics through the regulation of CNC b-Zip transcription factors in estrogen-induced breast carcinogenesis
    Anwesha Chatterjee
    Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri Kansas City, Kansas City, MO, 64108, USA
    J Biochem Mol Toxicol 28:529-38. 2014
    ..mRNA and protein expression levels of CNC b-zip transcription factors nuclear factor erythroid 2-related factor 1 (Nrf1), nuclear factor erythroid 2 related factor 2 (Nrf2), nuclear factor erythroid 2 related factor 3 (Nrf3), and Nrf2-..
  35. doi Body mass index associated to rs2021966 ENPP1 polymorphism increases the risk for gestational diabetes mellitus
    Federica Tarquini
    Department of Surgical and Biomedical Sciences, Section of Obstetrics and Gynecology, University of Perugia, Perugia, Italy
    Gynecol Endocrinol 31:83-6. 2015
    ..SNPs for ENPP1, NRF1, VEGFA, CEBPA, and PIK3R1 were analyzed by SNP genotyping...
  36. pmc Long-Term Gestational Hypoxia Modulates Expression of Key Genes Governing Mitochondrial Function in the Perirenal Adipose of the Late Gestation Sheep Fetus
    Dean A Myers
    Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Reprod Sci 22:654-63. 2015
    ..Long-term hypoxia increased (P < .05) perirenal eNOS and phospho-eNOS, messenger RNA (mRNA) for NRF1, NRF-2, mtTFA as well as COX-I, COX-II, and COX-IV mRNA...
  37. doi The Neuroprotective Effect of Glycyrrhizic Acid on an Experimental Model of Focal Cerebral Ischemia in Rats
    Tarik Akman
    Department of Neurosurgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey
    Inflammation 38:1581-8. 2015
    ..Malondialdehyde (MDA), superoxide dismutase (SOD), and nuclear respiratory factor-1 (NRF1) levels were analyzed biochemically on the right cerebral hemisphere, while ischemic histopathological studies were ..
  38. pmc Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging
    Mary Mohrin
    Program in Metabolic Biology, Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA
    Science 347:1374-7. 2015
    ..branch of the mitochondrial unfolded protein response (UPR(mt)), which is mediated by the interplay of SIRT7 and NRF1 and is coupled to cellular energy metabolism and proliferation...
  39. pmc The Protective Effects of Salidroside from Exhaustive Exercise-Induced Heart Injury by Enhancing the PGC-1 α -NRF1/NRF2 Pathway and Mitochondrial Respiratory Function in Rats
    Zheng Ping
    Department of Cardiology, Geriatric Cardiovascular Disease Research and Treatment Center, No 252 Hospital of PLA, Baoding 071000, China
    Oxid Med Cell Longev 2015:876825. 2015
    To test the hypothesis that salidroside (SAL) can protect heart from exhaustive exercise-induced injury by enhancing mitochondrial respiratory function and mitochondrial biogenesis key signaling pathway PGC-1α-NRF1/NRF2 in rats.
  40. doi Acute Carnosine Administration Increases Respiratory Chain Complexes and Citric Acid Cycle Enzyme Activities in Cerebral Cortex of Young Rats
    Levy W Macedo
    Laboratório de Erros Inatos do Metabolismo, Universidade do Extremo Sul Catarinense, Criciuma, SC, Brazil
    Mol Neurobiol 53:5582-90. 2016
    ..RT-PCR (RT-qPCR) data on mRNA levels of mitochondrial biogenesis-related proteins (nuclear respiratory factor 1 (Nrf1), peroxisome proliferator-activated receptor-γ coactivator 1-α (Ppargc1α), and mitochondrial transcription ..
  41. doi Oleuropein induces mitochondrial biogenesis and decreases reactive oxygen species generation in cultured avian muscle cells, possibly via an up-regulation of peroxisome proliferator-activated receptor γ coactivator-1α
    Motoi Kikusato
    Animal Nutrition, Life Sciences, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi, Japan
    Anim Sci J 87:1371-1378. 2016
    ..as well as peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), nuclear respiratory factor-1 (NRF1), mitochondrial transcription factor A (TFAM) and ATP5a1 (a component of mitochondrial adenosine triphosphate ..
  42. doi Nuclear Factor Erythroid-2 Like 1 (NFE2L1): Structure, function and regulation
    Hyun Min Kim
    Department of Laboratory Medicine and Pathology, University of California, Irvine, D440 Medical Sciences, Irvine, CA 92697, USA
    Gene 584:17-25. 2016
    Nrf1 (also referred to as NFE2L1) is a member of the CNC-bZIP family of transcription factors that are characterized by a highly conserved CNC-domain, and a basic-leucine zipper domain required for dimerization and DNA binding...
  43. pmc Akt3 knockdown induces mitochondrial dysfunction in human cancer cells
    Minjee Kim
    Department of Biochemistry, College of Medicine, Dong A University, Busan 607 714, Republic of Korea Institute of Convergence Bio Health, Dong A University, Busan 607 714, Republic of Korea
    Acta Biochim Biophys Sin (Shanghai) 48:447-53. 2016
    ..increased in the Akt1- and Akt3-knockdown cells, and this increase was accompanied by an increase in TFAM and NRF1. Akt2 knockdown did not cause a similar effect...
  44. pmc The Role of Nuclear Factor-E2-Related Factor 1 in the Oxidative Stress Response in MC3T3-E1 Osteoblastic Cells
    So Young Park
    Department of Internal Medicine, Cheil General Hospital and Women s Healthcare Center, Dankook University College of Medicine, Seoul, Korea
    Endocrinol Metab (Seoul) 31:336-42. 2016
    ..Nuclear factor-E2-related factor 1 (NFE2L1, Nrf1) is known to regulate the expression of a number of genes involved in oxidative stress and inflammation...
  45. pmc A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease
    J Carlos Villaescusa
    Laboratory of Molecular Neurobiology, DBRM, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic Psychiatric Stem Cell Group, Neurogenetics Unit, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
    EMBO J 35:1963-78. 2016
    ..genes, such as Onecut2 to inhibit lateral fates during embryogenesis, Pitx3 to promote mDAn development, and Nfe2l1 to protect from oxidative stress...
  46. doi Magnesium and calcium-enriched deep-sea water promotes mitochondrial biogenesis by AMPK-activated signals pathway in 3T3-L1 preadipocytes
    Byung Geun Ha
    Biomedical Research Institute, Kyungpook National University Hospital, Daegu, South Korea
    Biomed Pharmacother 83:477-484. 2016
    ..Quantitative real-time PCR revealed that BDSW enhances expression of PGC1-α, NRF1, and TFAM genes...
  47. doi Nrf1 can be processed and activated in a proteasome-independent manner
    Janakiram R Vangala
    Department of Pathology, Virginia Commonwealth University, Richmond, VA 23298, USA
    Curr Biol 26:R834-5. 2016
    In response to proteasome inhibition, the transcription factor Nrf1 facilitates de novo synthesis of proteasomes by inducing proteasome subunit (PSM) genes [1,2]...
  48. pmc Reply to Vangala et al.: Complete inhibition of the proteasome reduces new proteasome production by causing Nrf1 aggregation
    Zhe Sha
    Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Curr Biol 26:R836-7. 2016
    ..adaptation of cells to proteasome inhibition is the induction of new proteasomes via the transcription factor Nrf1 [1,2], which is produced as a precursor bound to the endoplasmic reticulum (ER) through its amino terminus...
  49. pmc Dietary Probiotic Bacillus subtilis Strain fmbj Increases Antioxidant Capacity and Oxidative Stability of Chicken Breast Meat during Storage
    Wen Kai Bai
    College of Animal Science and Technology, Nanjing Agricultural University, Xuanwu District, Nanjing, People s Republic of China
    PLoS ONE 11:e0167339. 2016
    ..GSH), mRNA expression of antioxidant genes (Nrf2, HO-1, SOD, CAT, GSH-Px) and mitochondrial function genes (avUCP, NRF1, NRF2, TFAM, PGC-1α), oxidative damage index (MDA, ROS, PC, 8-OHdG), and MMP level in chicken breast meat as ..
  50. ncbi The gene (NFE2L1) for human NRF-1, an activator involved in nuclear-mitochondrial interactions, maps to 7q32
    V Tiranti
    Division of Biochemistry and Genetics, C Besta National Neurological Institute, Milan, Italy
    Genomics 27:555-7. 1995
  51. ncbi The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development
    S C Farmer
    Department of Biochemistry and Molecular Genetics, School of Medicine, University of Alabama at Birmingham, 35294, USA
    Genes Dev 11:786-98. 1997
    ..LCR-F1 and the related bZIP transcription factors NF-E2 p45 and NRF2 must compensate for each other in globin gene regulation...
  52. ncbi Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone oxidoreductase1 gene
    S Dhakshinamoorthy
    Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 275:40134-41. 2000
    ..The nuclear transcription factor Nrf2 and Nrf1 bind to the ARE and positively regulate expression and induction of the NQO1 and GST Ya genes...
  53. pmc 4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling
    Hongqiao Zhang
    Department of Environmental Health Science, School of Public Health, University of Alabama at Birmingham, USA
    Am J Respir Cell Mol Biol 34:174-81. 2006
    ..HNE-increased nuclear content of Nrf1, Nrf2, and c-Jun in L2 cells was partially blocked by inhibition of either ERK1/2 or p38MAPK and completely blocked ..
  54. pmc The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation
    Yiguo Zhang
    Biomedical Research Center, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Biochem J 408:161-72. 2007
    b>Nrf1 (nuclear factor-erythroid 2 p45 subunit-related factor 1) is negatively controlled by its NTD (N-terminal domain) that lies between amino acids 1 and 124...
  55. pmc Mitochondrial DNA content, an inaccurate biomarker of mitochondrial alteration in human immunodeficiency virus-related lipodystrophy
    Min Ji Kim
    INSERM, U582, Paris, F 75013 France
    Antimicrob Agents Chemother 52:1670-6. 2008
    ..However, the expression of the known transcription factors of mitochondrial biogenesis (TFAM, NRF1, GABPA, PPARGC1A, PPARGC1B, and PPRC1) was normal or decreased...
  56. doi Interaction of USF1/USF2 and alpha-Pal/Nrf1 to Fmr-1 promoter increases in mouse brain during aging
    S Prasad
    Biochemistry and Molecular Biology Lab, CAS in Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India
    Biochem Biophys Res Commun 376:347-51. 2008
    ..mechanism is linked to aging, we have studied interaction of the transcription factors USF1/USF2 and alpha-Pal/Nrf1 to E-box and GC-box, respectively, in Fmr-1 promoter in the brain of young, adult, and old mouse using ..
  57. doi Targeted disruption of nuclear factor erythroid-derived 2-like 1 in osteoblasts reduces bone size and bone formation in mice
    Jonghyun Kim
    Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, Loma Linda University, Loma Linda, CA 92357, USA
    Physiol Genomics 40:100-10. 2010
    Previous in vitro studies found that nuclear factor erythroid-derived 2-like 1 (NFE2L1) was involved in mediating ascorbic acid-induced osterix expression and osteoblast differentiation via binding to the antioxidant response element of ..
  58. doi Dynamic regulation of mitochondrial network and oxidative functions during 3T3-L1 fat cell differentiation
    Pierre Henri Ducluzeau
    INSERM U694, Univerité d Angers, CHU Angers, 4 rue Larrey, Angers, France
    J Physiol Biochem 67:285-96. 2011
    ..to uncoupled respiration with a tendency towards decreased membrane potential, with no variation of mtTFA and NRF1 gene expression...
  59. pmc The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia
    Nikolai L Chepelev
    Department of Biology, Carleton University, Ottawa, Ontario, Canada
    PLoS ONE 6:e29167. 2011
    b>Nrf1 (nuclear factor-erythroid 2 p45 subunit-related factor 1) is a transcription factor mediating cellular responses to xenobiotic and pro-oxidant stress...
  60. pmc Defects of mtDNA replication impaired mitochondrial biogenesis during Trypanosoma cruzi infection in human cardiomyocytes and chagasic patients: the role of Nrf1/2 and antioxidant response
    Xianxiu Wan
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    J Am Heart Assoc 1:e003855. 2012
    ....
  61. pmc Curcumin protects human keratinocytes against inorganic arsenite-induced acute cytotoxicity through an NRF2-dependent mechanism
    Rui Zhao
    Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang, Liaoning 110001, China
    Oxid Med Cell Longev 2013:412576. 2013
    ..High concentration of curcumin (20 μM) also increased protein expression of long isoforms of NRF1. Treatment with low concentrations of curcumin (2...
  62. doi Triiodothyronine induces lipid oxidation and mitochondrial biogenesis in rat Harderian gland
    A Santillo
    Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Universita degli Studi di Napoli, Via Vivaldi, 43, 81100 Caserta, Italy
    J Endocrinol 219:69-78. 2013
    ..Indeed, hypothyroid status did not modify the expression of mitochondrial biogenesis genes such as Ppargc1a, Nrf1 and Tfam, whereas T3 treatment increased the expression level of these genes.
  63. doi Regulation of the biogenesis of OXPHOS complexes in cell transition from replicating to quiescent state: involvement of PKA and effect of hydroxytyrosol
    Anna Signorile
    Department of Basic Medical Sciences, Neurosciences and Sense organs, University of Bari Aldo Moro, Bari 70124, Italy Electronic address
    Biochim Biophys Acta 1843:675-84. 2014
    ..receptor gamma coactivator 1-alpha (PGC-1α) and the down-stream nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factors (TFAM)...
  64. pmc Dietary fucoxanthin increases metabolic rate and upregulated mRNA expressions of the PGC-1alpha network, mitochondrial biogenesis and fusion genes in white adipose tissues of mice
    Meng Ting Wu
    Department of Biochemical Science and Technology, National Taiwan University, No 1, Sec 4, Roosevelt Road, Taipei 10617, Taiwan
    Mar Drugs 12:964-82. 2014
    ..Mitochondrial biogenic genes, nuclear respiratory factor 1 (NRF1) and NRF2, were increased in eWAT by FX...
  65. doi Identification of novel transcription factors in osteoclast differentiation using genome-wide analysis of open chromatin determined by DNase-seq
    Kazuki Inoue
    Division of Integrative Pathophysiology, Proteo Science Center, Graduate School of Medicine, Ehime University, Ehime, Japan Department of Biological Resources, Integrated Center for Sciences, Ehime University, Ehime, Japan
    J Bone Miner Res 29:1823-32. 2014
    ..Jun, CREB1, FOS, ATF2, and ATF4, but also novel transcription factors for osteoclastogenesis such as Zscan10, Atf1, Nrf1, and Srebf2. siRNA knockdown of these identified novel transcription factors impaired osteoclastogenesis...
  66. doi Delphinidin inhibits VEGF induced-mitochondrial biogenesis and Akt activation in endothelial cells
    Lucie Duluc
    LUNAM, INSERM U1063, F 49100 Angers, France UFR médecine, Universite d Angers, Rue Haute de Reculee, F 49045 Angers, France Electronic address
    Int J Biochem Cell Biol 53:9-14. 2014
    ..Delphinidin increased mRNA expression of several mitochondrial biogenesis factors, including NRF1, ERRα, Tfam, Tfb2m and PolG but did not affect neither mitochondrial respiration, DNA content nor enzyme ..
  67. pmc Direct interaction between the WD40 repeat protein WDR-23 and SKN-1/Nrf inhibits binding to target DNA
    Chi K Leung
    Department of Biology and Genetics Institute, University of Florida, Gainesville, Florida, USA
    Mol Cell Biol 34:3156-67. 2014
    ..Two of these SKN-1 motifs are highly conserved in human Nrf1 and Nrf2 and two directly interact with target DNA...
  68. pmc The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression
    Yiguo Zhang
    The Laboratory of Cell Biochemistry and Gene Regulation, College of Medical Bioengineering and Faculty of Life Sciences, Chongqing University, Shapingba District, Chongqing, China
    PLoS ONE 9:e109159. 2014
    The C-terminal domain (CTD, aa 686-741) of nuclear factor-erythroid 2 p45-related factor 1 (Nrf1) shares 53% amino acid sequence identity with the equivalent Neh3 domain of Nrf2, a homologous transcription factor...
  69. pmc Inducible nitric oxide synthase (iNOS) regulatory region variation in non-human primates
    Morteza Roodgar
    Graduate Group of Comparative Pathology, School of Veterinary Medicine, University of California, Davis, United States Molecular Anthropology Laboratory, Department of Anthropology, University of California, Davis, United States California National Primate Research Center CNPRC, University of California, Davis, United States Electronic address
    Infect Genet Evol 31:236-44. 2015
    ..to iNOS regulation: AP-1, C/EBPB, CREB, GATA-1, GATA-3, NF-AT, NF-AT5, NF-κB, KLF4, Oct-1, PEA3, SMAD3, and TCF11. Additionally, we found evidence of interspecies variation in binding sites for several regulatory elements linked ..
  70. doi FSH and bFGF regulate the expression of genes involved in Sertoli cell energetic metabolism
    Mariana Regueira
    Centro de Investigaciones Endocrinológicas Dr César Bergadá, CONICET FEI División de Endocrinología, Hospital de Ninos Ricardo Gutierrez, Gallo 1330, C1425EDF Buenos Aires, Argentina
    Gen Comp Endocrinol 222:124-33. 2015
    ..LCAD, MCAD), and of genes involved in mitochondrial biogenesis such as: nuclear respiratory factors 1 and 2 (NRF1, NRF2) and transcription factor A (Tfam), was analyzed...
  71. doi The Infertility of Repeat-Breeder Cows During Summer Is Associated with Decreased Mitochondrial DNA and Increased Expression of Mitochondrial and Apoptotic Genes in Oocytes
    Roberta Machado Ferreira
    Departamento de Reprodução Animal, Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo, Sao Paulo, Sao Paulo, Brazil Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos da Universidade de São Paulo, Pirassununga, Sao Paulo, Brazil
    Biol Reprod 94:66. 2016
    ..used to evaluate mtDNA amounts as well as the expression levels of genes associated with the mitochondria (MT-CO1, NRF1, POLG, POLG2, PPARGC1A, and TFAM), apoptosis (BAX, BCL2, and ITM2B), and oocyte maturation (BMP15, FGF8, FGF10, ..
  72. doi Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis
    Jung Woo Kang
    School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi Do, Korea
    J Pineal Res 60:383-93. 2016
    ..Parkin; peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α); nuclear respiratory factor 1 (NRF1); and transcription factor A, mitochondrial (TFAM)...
  73. pmc DNA methylation-mediated transcription factors regulate Piwil1 expression during chicken spermatogenesis
    Lingling Qiu
    College of Animal Science and Technology, Yangzhou University, Jiangsu 225009, China
    J Reprod Dev 62:367-72. 2016
    ..that methylation of the -148 CpG site, which is the predicted binding site for the transcription factors TCF3 and NRF1, was differentially methylated in different spermatogenic cells...
  74. doi Early Stress History Alters Serum Insulin-Like Growth Factor-1 and Impairs Muscle Mitochondrial Function in Adult Male Rats
    S Ghosh
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai, Maharashtra, India
    J Neuroendocrinol 28:. 2016
    ..Furthermore, the expression of several genes involved in mitochondrial function, such as Ppargc1a, Nrf1, Tfam, Cat, Sesn3 and Ucp3, was reduced in skeletal muscle...
  75. ncbi TCF11/Nrf1-Mediated Induction of Proteasome Expression Prevents Cytotoxicity by Rotenone
    Franziska Sotzny
    1 Charité Universitätsmedizin Berlin, Institut fur Biochemie, Berlin, Germany
    Antioxid Redox Signal 25:870-885. 2016
    ..We have previously shown that the transcription factor TCF11/Nrf1 induces antioxidant response element-mediated upregulation of UPS components in response to proteotoxic ..
  76. doi Methylene blue improves sensorimotor phenotype and decreases anxiety in parallel with activating brain mitochondria biogenesis in mid-age mice
    Artem P Gureev
    Department of Genetics, Cytology and Bioengineering, Voronezh State University, Voronezh, Russia
    Neurosci Res 113:19-27. 2016
    ..The expression of several genes relevant to mitochondria biogenesis, bioenergetics, and antioxidant defense (NRF1, MTCOX1, TFAM, and SOD2) was greatly suppressed in aged mice; it was restored by MB treatment...
  77. pmc Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases
    Mark Preciados
    Department of Environmental and Occupational Health, Florida International University, Miami, FL 33199, USA
    Int J Mol Sci 17:. 2016
    ..Effects on EEDs-modified estrogen and nuclear respiratory factor 1 (NRF1) signaling genes with exposure to natural estrogen, pharmacological estrogen-ethinyl estradiol, PCBs, phthalates, ..
  78. pmc Identification of a Nuclear Respiratory Factor 1 Recognition Motif in the Apolipoprotein E Variant APOE4 linked to Alzheimer's Disease
    Anne Urfer-Buchwalder
    Selonterra LLC, 1025 Alameda de las Pulgas, Suite 126, Belmont CA 94002, USA
    Sci Rep 7:40668. 2017
    ..search predicts that the T to C transition in rs429358 generates a binding motif for nuclear respiratory factor NRF1. This site appears to be part of a binding site cluster for this transcription factor on exon 4 of APOE...
  79. doi A rich medium-chain triacylglycerol diet benefits adiposity but has adverse effects on the markers of hepatic lipogenesis and beta-oxidation
    Carolina Maria de Oliveira Chamma
    Laboratory of Morphometry, Metabolism and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
    Food Funct . 2017
    ..HF-MCT100% group had raised markers of beta-oxidation (UCP3 and MCAD) and mitochondrial biogenesis (PGC1-alpha and NRF1)...
  80. pmc Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling
    Liming Yu
    Department of Cardiovascular Surgery, General Hospital of Shenyang Military Area Command, 83 Wenhua Road, Shenyang, Liaoning 110016, China
    Sci Rep 7:41337. 2017
    ..Importantly, melatonin also activated AMPK-PGC-1α-SIRT3 signaling and increased SOD2, NRF1 and TFAM expressions...
  81. pmc Hypoxia reduces testosterone synthesis in mouse Leydig cells by inhibiting NRF1-activated StAR expression
    Xueting Wang
    Department of Biochemistry, Institute for Nautical Medicine, Nantong University, China
    Oncotarget . 2017
    ..Hypoxic exposure caused a significant decrease of NRF1. Software analysis reported that the promoter region of steroidogenic acute regulatory protein (StAR) contained ..
  82. pmc Isolation of cDNA encoding the human NF-E2 protein
    J Y Chan
    Department of Laboratory Medicine, University of California, San Francisco 94143 0724
    Proc Natl Acad Sci U S A 90:11366-70. 1993
    ..Comparison to the related protein, Nrf1, revealed significant homologies at isolated regions, particularly within the basic domain, suggesting that NF-E2 ..
  83. ncbi Nrf2 regulates thromboxane synthase gene expression in human lung cells
    Masahiro Yaekashiwa
    Division of Hematology, Department of Internal Medicine, University of Texas Houston, Houston, Texas 77030, USA
    DNA Cell Biol 22:479-87. 2003
    ..25% of the wild-type promoter activity. Ecotopic expression of NF-E2 related factors showed that Nrf2, but not Nrf1, Nrf3, or Bach1, activated TXAS promoter in a dose-dependent manner...
  84. ncbi Identification and characterization of the human Cdc2l2 gene promoter
    Yongmei Feng
    Department of Pathology, Arizona Cancer Center, University of Arizona, 1515 N Campbell Ave, Tucson, AZ 85724, USA
    Gene 330:75-84. 2004
    ..sites were found to be present in this region, such as two Ets-1, one cAMP-responsive element (CRE) and one TCF11/LCR-F1/Nrf1 binding sites...
  85. pmc Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia
    Zhenrong Xu
    Department of Pathology, University of California, D440 Medical Sciences, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 102:4120-5. 2005
    Knockout studies have shown that the transcription factor Nrf1 is essential for embryonic development...
  86. pmc A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication
    Man Lung Yeung
    Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Biol Chem 284:19463-73. 2009
    ..Twenty-two of these mRNAs were secondarily verified for their contributions to HIV-1 replication. Five mRNAs, NRF1, STXBP2, NCOA3, PRDM2, and EXOSC5, were studied for their effect on steps of the HIV-1 life cycle...
  87. pmc Impaired PGC-1alpha function in muscle in Huntington's disease
    Rajnish K Chaturvedi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, NY 10065, USA
    Hum Mol Genet 18:3048-65. 2009
    ..Oxygen consumption, PGC-1alpha, NRF1 and response to GPA were significantly reduced in myoblasts from HD patients...
  88. pmc Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans
    Kristoffer Sølvsten Burgdorf
    Hagedorn Research Institute, Copenhagen, Denmark
    PLoS ONE 6:e15813. 2011
    A study of 222 candidate genes in type 2 diabetes reported association of variants in RAPGEF1, ENPP1, TP53, NRF1, SLC2A2, SLC2A4 and FOXC2 with type 2 diabetes in 4,805 Finnish individuals...
  89. pmc Estrogen receptor mediates a distinct mitochondrial unfolded protein response
    Luena Papa
    Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Sci 124:1396-402. 2011
    ..estrogen receptor (ER) activity, which further upregulates the transcription of the mitochondrial regulator NRF1 and the IMS protease OMI (officially known as HTRA2)...
  90. pmc Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst
    Kartik Shankar
    Arkansas Children s Nutrition Center, 15 Children s Way, Slot 512 20B, Little Rock, Arkansas 72202, USA
    Endocrinology 152:4158-70. 2011
    ..proinflammatory genes (CCL4 and CCL5) increased and expression of antioxidant (GPx3) and mitochondrial (TFAM and NRF1) genes decreased in the obese embryos...
  91. pmc Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia
    Eugene Khandros
    Cell and Molecular Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 119:5265-75. 2012
    ..coordinated induction of most proteasome subunits that was mediated by the stress-response transcription factor Nrf1. In isolated thalassemic cells, short-term proteasome inhibition blocked the degradation of free α-globin...
  92. pmc Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability
    Diane H Oh
    Department of Laboratory Medicine and Pathology, University of California at Irvine, USA
    FEBS J 279:4121-30. 2012
    Nuclear factor erythroid-derived 2-related factor 1 (Nrf1) regulates cellular stress response genes, and has also been suggested to play a role in other cellular processes...
  93. doi Dynamic mobilization of PGC-1α mediates mitochondrial biogenesis for the protection of RGC-5 cells by resveratrol during serum deprivation
    Shida Chen
    Division of Glaucoma, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54S Xianlie Road, 510060 Guangzhou, China
    Apoptosis 18:786-99. 2013
    ..PGC-1α; instead, resveratrol facilitated PGC-1α translocation from the cytoplasm to the nucleus and up-regulated NRF1 and TFAM, which were blocked by nicotinamide...
  94. doi Short exposure to a diet rich in both fat and sugar or sugar alone impairs place, but not object recognition memory in rats
    Jessica E Beilharz
    School of Medical Sciences, University of New South Wales, Australia
    Brain Behav Immun 37:134-41. 2014
    ..hippocampal inflammation (TNF-α and IL-1β mRNA) and oxidative stress, as indicated by an upregulation of NRF1 mRNA compared to control rats...
  95. pmc Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97
    Zhe Sha
    Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Curr Biol 24:1573-83. 2014
    ..In response to these inhibitors, cells enhance the expression of proteasome subunits by the transcription factor Nrf1. Here, we investigate the mechanisms by which decreased proteasome function triggers production of new proteasomes ..
  96. pmc CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion
    Hongzhi Zheng
    1 The First Affiliated Hospital, China Medical University, Shenyang, China
    Antioxid Redox Signal 22:819-31. 2015
    ..We investigated both the in vitro and in vivo effects of deficiency of nuclear factor-erythroid 2-related factor 1 (Nrf1) in β-cells on β-cell function and glucose homeostasis.
  97. pmc Effects of discontinuing a high-fat diet on mitochondrial proteins and 6-hydroxydopamine-induced dopamine depletion in rats
    Delin Ma
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
    Brain Res 1613:49-58. 2015
    ..Proteins related to mitochondrial function (such as AMPK, PGC-1α), and to proteasomal function (such as TCF11/Nrf1) were influenced by diet intervention, or by 6-OHDA lesion...
  98. doi Discovery of an NRF1-specific inducer from a large-scale chemical library using a direct NRF1-protein monitoring system
    Tadayuki Tsujita
    Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Genes Cells 20:563-77. 2015
    b>NRF1 (NF-E2-p45-related factor 1) plays an important role in the regulation of genes encoding proteasome subunits, a cystine transporter, and lipid-metabolizing enzymes...
  99. doi The Effect of Coumaric Acid on Ischemia-Reperfusion Injury of Sciatic Nerve in Rats
    Mustafa Guven
    Department of Neurosurgery, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey
    Inflammation 38:2124-32. 2015
    ..A significant decrease in MDA, an increase in NRF1 levels, and increase in SOD activity were observed in the groups which received coumaric acid and ..
  100. doi Distinct profiles of human embryonic stem cell metabolism and mitochondria identified by oxygen
    Jarmon G Lees
    School of BiosciencesUniversity of Melbourne, Parkville 3010, Victoria, AustraliaMenzies Institute of Medical ResearchUniversity of Tasmania, Hobart 7000, Tasmania, Australia
    Reproduction 150:367-82. 2015
    ..culture, MEL2 hES cells displayed reduced mtDNA content, mitochondrial mass and expression of metabolic genes TFAM, NRF1, PPARa and MT-ND4...
  101. doi [CNC proteins in physiology and pathology]
    Agnieszka Gęgotek
    Zakład Chemii Nieorganicznej i Analitycznej, Uniwersytet Medyczny w Białymstoku
    Postepy Hig Med Dosw (Online) 69:729-43. 2015
    CNC proteins consist of Bach1, Bach2 and 4 homologous transcription factors: Nrf1, Nrf2, Nrf3 and p45NF-E2. Transcription factors belonging to this group of proteins play a crucial role in protection of cells against oxidative stress...

Research Grants27

  1. GLOBIN GENE EXPRESSION DURING DEVELOPMENT
    Tim Townes; Fiscal Year: 2002
    ..The investigator has recently described a new erythroid-specific transcription factor, LCR-F1, that modulates globin gene expression. ..
  2. NRF1 IN OXIDATIVE STRESS
    Jefferson Chan; Fiscal Year: 2003
    ..Since these same pathways are affected in cancer cells, it is hoped that these studies will also contribute to a better understanding of malignancy and provide insights into novel therapeutics. ..
  3. UBALDO EMILIO MARTINEZ OUTSCHOORN; Fiscal Year: 2016
    ..with high OXPHOS metabolism via upregulation of monocarboxylate transporter 1 (MCT1), nuclear respiration factor 1 (NRF1) and mitoNEET and stromal cells with low OXPHOS metabolism and high catabolism via upregulation of monocarboxylate ..
  4. Nisha Jain Garg; Fiscal Year: 2016
    ..cells, and establish an environment conducive to fibrosis, (2) Test the hypothesis that PARP-1/PAR deregulates Nrf1/2 pathway and play a key role in chronic oxidative/inflammatory state of chagasic heart, and (3) Test the ..
  5. David A Sinclair; Fiscal Year: 2016
    ..to a novel SIRT1-mediated pathway that does not involve the canonical factors PGC- 1[unreadable]/[unreadable] or NRF1/2...
  6. Subburaman Mohan; Fiscal Year: 2015
    ....
  7. Claude A Piantadosi; Fiscal Year: 2016
    ..Our Specific Aims are: Aim 1: Determine whether Nfe2l2 and NRF1 induction of lung mitochondrial biogenesis in murine S...
  8. REGULATION OF CYCLIN D1 EXPRESSION
    Richard G Pestell; Fiscal Year: 2010
    ..Cyclin D1 inhibits mitochondrial metabolism. Cyclin D1 phosphorylates and inactivates a transcription factor NRF1 that in turn regulates mitochondrial gene expression...
  9. MATTHEW THOMAS HURD; Fiscal Year: 2014
    ..g. Nrf1) and in Aim 2 will be analyzed to tes the possible role of acetylation at K158 (or K149) in regulating MYC ..
  10. THOMAS K BLACKWELL; Fiscal Year: 2015
    ..elegans that the transcription factor SKN-1 (mammalian Nrf1/2/3) is also central to the UPR...
  11. Jefferson Y Chan; Fiscal Year: 2014
    ..Members of the CNC subfamily of basic-leucine zipper transcription factors including Nrf1 and Nrf2 have been implicated to mediate ARE function...
  12. Jefferson Y Chan; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Nrf1 and Nrf2 are members of the CNC family of bZIP transcription factors that exhibit structural similarities, and both are expressed in a wide range of tissues...
  13. Understanding and targeting Nrf1-mediated proteasome recovery pathway in cancer
    SENTHIL KUMAR RADHAKRISHNAN; Fiscal Year: 2012
    ..Preliminary studies indicated that this response was mediated by the transcription factor Nrf1 (also called Nfe2l1) and that knockdown of this factor sensitized cancer cells to proteasome inhibitor treatments...
  14. MKK3 is a Mediator of Sepsis and Lung Injury in the Elderly
    Praveen Mannam; Fiscal Year: 2013
    ..In the process, we found that MKK3 modulates key pathways associated with aging such as Nrf1, Sirt1, mitochondrial health and mitophagy...
  15. C/EBP Regulation of Dentinogenesis
    John Harrison; Fiscal Year: 2009
    ..electron microscopy, and immunohistochemical localization of endogenous C/EBP and its dimerization partner Nrf1. 2) To assess cell autonomy of the odontoblast phenotype using ex vivo dental pulp cultures and heterologous pulp ..
  16. Investigation of the Function and Regulationof Peroxiredoxins Prdx1 and Prdx6 in
    SHELLEY PHELAN; Fiscal Year: 2009
    ..lines for binding activity of candidate regulatory transcription factors (Sp1, AP1, Egr1, SRF, E2F, c-myc, p53, Nrf1 and Nrf2) and binding to putative binding sites in the Prdx1 and Prdx6 promoters...
  17. GAMMA GCS REGULATION--REGULATORY/CATALYTIC SUBUNIT GENES
    R Mulcahy; Fiscal Year: 2002
    ..dimeric transcription factors composed of small Maf proteins and various other bZIP family members, including Nrf1, Nrf2, Fos and Jun...
  18. STRUCTURE AND FUNCTION OF THE LCR-F1 GENE
    SUSAN FARMER; Fiscal Year: 1999
    ..research project is to characterize the structure and function of the gene for a transcription factor, locus control region factor 1 (LCR-F1)...
  19. Nrf1 function by conditional knockout
    Jefferson Chan; Fiscal Year: 2003
    This grant proposal is in response to PAR-98-087, and is linked to K08-DK02603, which focuses on the role of Nrf1 in oxidative stress...
  20. Role of P-gp in perivascular HIV-1 sanctuary and HAART
    Debasis Mondal; Fiscal Year: 2007
    ..The proposed studies are expected to provide exploratory new information on existence of a perivascular endothelial barrier that may compromise the effectiveness of Pis and allow development of an HTV-1 sanctuary. ..
  21. REGULATION OF HEPATIC GLUTATHIONE SYNTHESIS
    Shelly Lu; Fiscal Year: 2008
    ..Our ultimate goal is to utilize this information to improve the treatment and prevent complications that may result from altered hepatic GSH synthesis. [unreadable] [unreadable]..
  22. MAT1A NULL MOUSE: MODEL FOR ALCOHOLIC TISSUE INJURY
    Shelly Lu; Fiscal Year: 2007
    ....
  23. MOLECULAR ANALYSIS OF TRISTETRAPROLIN FUNCTION
    Thomas Blackwell; Fiscal Year: 2005
    ..abstract_text> ..
  24. FUNCTIONS OF A CONSERVED GERMLINE HELICASE IN C.ELEGANS
    Thomas Blackwell; Fiscal Year: 2005
    ..At the same time, they will elucidate post-transcriptional gene regulation mechanisms that may be of conserved importance during gametogenesis, and possibly for proliferation or survival of other stem cell types. ..
  25. Gene Expression in Prediabetes: Potential Role of PGC-1
    MARY PATTI; Fiscal Year: 2006
    ..abstract_text> ..
  26. ALTERED METHIONINE METABOLISM IN ALCOHOLIC LIVER INJURY
    Shelly Lu; Fiscal Year: 2005
    ....