neuropilin 1

Summary

Gene Symbol: neuropilin 1
Description: neuropilin 1
Alias: BDCA4, CD304, NP1, NRP, VEGF165R, neuropilin-1, transmembrane receptor, vascular endothelial cell growth factor 165 receptor
Species: human

Top Publications

  1. ncbi Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting
    Qi Pan
    Department of Tumor Biology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 282:24049-56. 2007
  2. ncbi Neuropilin is a receptor for the axonal chemorepellent Semaphorin III
    Z He
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Cell 90:739-51. 1997
  3. ncbi Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors
    T Takahashi
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Cell 99:59-69. 1999
  4. pmc Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas
    Caroline Pellet-Many
    Centre for Cardiovascular Science and Medicine, Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK
    Biochem J 435:609-18. 2011
  5. pmc Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma
    Matija Snuderl
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell 152:1065-76. 2013
  6. ncbi Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration
    Ling Wang
    Department of Pathology, Beth Israel Deaconess Medical Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:48848-60. 2003
  7. ncbi Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2
    Matilde Murga
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 105:1992-9. 2005
  8. doi microRNA-320a inhibits tumor invasion by targeting neuropilin 1 and is associated with liver metastasis in colorectal cancer
    Yujun Zhang
    Institute of Clinical Molecular Biology, Department of Gastroenterology, Peking University, People s Hospital, Beijing 100044, PR China
    Oncol Rep 27:685-94. 2012
  9. pmc Neuropilin-1 modulates p53/caspases axis to promote endothelial cell survival
    Ling Wang
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 2:e1161. 2007
  10. pmc Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis
    Stephen D Robinson
    Adhesion and Angiogenesis Laboratory, Tumour Biology Centre, Institute of Cancer, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Biol Chem 284:33966-81. 2009

Research Grants

  1. ANNE CHRISTINE EICHMANN; Fiscal Year: 2015
  2. MUC1 enhances Neuropilin-1 signaling in pancreatic ductal adenocarcinoma
    Pinku Mukherjee; Fiscal Year: 2013
  3. Joseph H McCarty; Fiscal Year: 2016
  4. Tobias Meyer; Fiscal Year: 2014
  5. Fox Transcription Factors in Vascular Development
    Tsutomu Kume; Fiscal Year: 2012
  6. Susan J Fisher; Fiscal Year: 2016
  7. Michael Simons; Fiscal Year: 2016
  8. Signaling Mechanisms mediating effects of Semaphorin3A
    Zhigang He; Fiscal Year: 2005
  9. Effects of Semaphorin 3A on Stroke Recovery
    Klaus van Leyen; Fiscal Year: 2013
  10. MECHANISMS OF BREAST CARCINOMA SURVIVAL
    Arthur M Mercurio; Fiscal Year: 2010

Detail Information

Publications208 found, 100 shown here

  1. ncbi Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting
    Qi Pan
    Department of Tumor Biology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 282:24049-56. 2007
    ..VEGFR2 complex. Additionally, we show that VEGFR2 enhances VEGF(165), but not VEGF(121) binding to NRP1. We propose a new model for NRP1 interactions with various VEGF isoforms...
  2. ncbi Neuropilin is a receptor for the axonal chemorepellent Semaphorin III
    Z He
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Cell 90:739-51. 1997
    ..These results provide evidence that neuropilin is a receptor or a component of a receptor complex that mediates the effects of Sema III on these axons...
  3. ncbi Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors
    T Takahashi
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Cell 99:59-69. 1999
    ..Sema3A treatment leads to the redistribution of growth cone NP-1 and plexin into clusters. Thus, physiologic Sema3A receptors consist of NP-1/plexin complexes...
  4. pmc Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas
    Caroline Pellet-Many
    Centre for Cardiovascular Science and Medicine, Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, UK
    Biochem J 435:609-18. 2011
    ..These results indicate a role for NRP1 and NRP1 glycosylation in mediating PDGF-induced VSMC migration, possibly by acting as a co-receptor for PDGFRα and via selective mobilization of a novel p130Cas tyrosine phosphorylation pathway...
  5. pmc Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma
    Matija Snuderl
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell 152:1065-76. 2013
    ..Moreover, high expression of PlGF receptor neuropilin 1 (Nrp1) correlates with poor overall survival in patients...
  6. ncbi Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration
    Ling Wang
    Department of Pathology, Beth Israel Deaconess Medical Center, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:48848-60. 2003
    Neuropilin-1 (NRP-1) has been found to be expressed by endothelial cells and tumor cells as an isoform-specific receptor for vascular permeability factor/vascular endothelial growth factor (VEGF)...
  7. ncbi Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2
    Matilde Murga
    Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 105:1992-9. 2005
    Neuropilin-1 (NRP-1) is a type 1 membrane protein that binds the axon guidance factors belonging to the class-3 semaforin family...
  8. doi microRNA-320a inhibits tumor invasion by targeting neuropilin 1 and is associated with liver metastasis in colorectal cancer
    Yujun Zhang
    Institute of Clinical Molecular Biology, Department of Gastroenterology, Peking University, People s Hospital, Beijing 100044, PR China
    Oncol Rep 27:685-94. 2012
    ..miR-320a directly binds to the 3'UTR of neuropilin 1 (NRP-1), a protein that functions as a co-receptor of vascular epithelial growth factor...
  9. pmc Neuropilin-1 modulates p53/caspases axis to promote endothelial cell survival
    Ling Wang
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS ONE 2:e1161. 2007
    ..Here, we seek to define the function of NRP-1 in VPF/VEGF-induced survival signaling in EC and to elucidate the concomitant molecular signaling events that are ..
  10. pmc Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis
    Stephen D Robinson
    Adhesion and Angiogenesis Laboratory, Tumour Biology Centre, Institute of Cancer, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Biol Chem 284:33966-81. 2009
    ..Our data suggest that beta3 integrin may, in part, negatively regulate VEGF signaling by sequestering NRP1 and preventing it from interacting with VEGFR2...
  11. doi Neuropilin-1 is upregulated in hepatocellular carcinoma and contributes to tumour growth and vascular remodelling
    Mathieu Berge
    Institut des Vaisseaux et du Sang, Hopital Lariboisiere, Universite Paris 7, France
    J Hepatol 55:866-75. 2011
    ..Recent studies revealed an important role of NRP1 in angiogenesis and malignant progression of many cancers. The role of NRP1 in the development of hepatocellular carcinoma (HCC) is not completely understood...
  12. doi Neuropilin-1 is expressed by breast cancer stem-like cells and is linked to NF-κB activation and tumor sphere formation
    Yelena Glinka
    Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, ON, Canada M5B 1W8
    Biochem Biophys Res Commun 425:775-80. 2012
    ..We conclude that Nrp1 plays a key role in mammosphere formation and this activity is linked to NF-κB activation. Thus, Nrp1 might be a target for therapy against breast CSCs, and the anticancer drug tranilast suppresses its expression...
  13. doi The VEGF receptor, neuropilin-1, represents a promising novel target for chronic lymphocytic leukemia patients
    Agnieszka Piechnik
    Department of Experimental Hematooncology, Medical University of Lublin, Lublin, Poland
    Int J Cancer 133:1489-96. 2013
    ..In conclusion, NRP1 might represent an interesting link between angiogenesis and tolerance mechanisms and represents interesting target for therapy...
  14. doi Neuropilin-1 and neuropilin-2 expression in the adenoma-carcinoma sequence of colorectal cancer
    Carolyn A Staton
    Microcirculation Research Group, CR UK YCR Sheffield Cancer Research Centre, Department of Oncology, Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK
    Histopathology 62:908-15. 2013
    ..However, the precise role of NRP1 and NRP2 in the adenoma-carcinoma sequence (ACS) of colorectal cancer remains unclear, and we aimed to determine this in surgical specimens comprising the ACS...
  15. doi NRP-1 expression in bladder cancer and its implications for tumor progression
    Wen Cheng
    Department of Urology, Nanjing Jinling Hospital, Nanjing University School of Medicine, No 305, Zhongshandong Road, Nanjing, 210002, China
    Tumour Biol 35:6089-94. 2014
    Neuropilin-1 (NRP-1) overexpression has been reported in a variety of human cancers. However, the role of NRP-1 in bladder cancer (BC) remains unclear...
  16. pmc Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling
    Yasunori Shintani
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    EMBO J 25:3045-55. 2006
    ..These findings indicate that GAG modification of NRP1 plays a critical role in modulating VEGF signaling, and may provide new insights into physiological and pathological angiogenesis...
  17. ncbi Snake venom vascular endothelial growth factors (VEGFs) exhibit potent activity through their specific recognition of KDR (VEGF receptor 2)
    Yasuo Yamazaki
    Department of Biochemistry, Meiji Pharmaceutical University, 2 522 1, Noshio, Kiyose, Tokyo 204 8588, Japan
    J Biol Chem 278:51985-8. 2003
    ..Our data clearly indicate that snake venom VEGFs act through the specific activation of KDR and show potent effects. Snake venom VEGFs are a highly specific ligand to KDR and form a new group of the VEGF family...
  18. ncbi Cellular expression and hormonal regulation of neuropilin-1 and -2 messenger ribonucleic Acid in the human and rhesus macaque endometrium
    Ariane Germeyer
    Department of Gynecology and Obstetrics, Stanford University School of Medicine, 300 Pasteur Drive, HH 333, Stanford, California 94305 5317, USA
    J Clin Endocrinol Metab 90:1783-90. 2005
    ..The findings extend our understanding of VEGF action in the primate endometrium...
  19. ncbi Myeloid leukemias express a broad spectrum of VEGF receptors including neuropilin-1 (NRP-1) and NRP-2
    Anja Vales
    Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria
    Leuk Lymphoma 48:1997-2007. 2007
    ..We have examined the expression of five VEGF receptors (VEGR1/Flt-1, VEGFR2/KDR, Flt-4, neuropilin-1 = NRP-1, NRP-2) in leukemic cells obtained from patients with acute myeloid leukemia (n = 28), chronic myeloid leukemia (..
  20. pmc Neuropilin-1 identifies endothelial precursors in human and murine embryonic stem cells before CD34 expression
    Thomas Cimato
    National Human Genome Research Institute, and National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    Circulation 119:2170-8. 2009
    ..The objective of our study was to identify a single population of endothelial precursors with common identifying features from both human and murine embryonic stem cells...
  21. ncbi Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms
    M Rossignol
    Department of Surgical Research, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Genomics 70:211-22. 2000
    ..Five of the exons are identical in size in the two genes, suggesting that they arose by gene duplication. Both NRP genes are characterized by multiple alternatively spliced variants. Two NRP2 isoforms, NRP2a and NRP2b, were cloned...
  22. doi Vascular endothelial growth factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast growth factor-2
    David I R Holmes
    Centre for Cardiovascular Biology and Medicine, BHF Laboratories, Department of Medicine, University College London, 5 University Street, London, United Kingdom
    Cell Signal 20:569-79. 2008
    ..These findings support a role for NP-1 in mediating synergistic effects between VEGF-A(165) and FGF-2, which may occur in part through a contribution of NP-1 to KDR stability...
  23. ncbi Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells
    Robin E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Cancer Res 63:5230-3. 2003
    Neuropilin-1 (NP1), in conjunction with plexins, promotes axon repulsion by binding to semaphorin 3A (SEMA3A)...
  24. ncbi Correlation of neuropilin-1 overexpression to survival in acute myeloid leukemia
    M Kreuter
    Department of Medicine Hematology and Oncology, University of Muenster, Muenster, Germany
    Leukemia 20:1950-4. 2006
    Neuropilin-1 (NRP-1), a vascular endothelial growth factors and semaphorin receptor functioning as mediator of angiogenesis and neuronal guidance, is expressed by various solid tumors...
  25. doi Neuropilin-1 is not a marker of human Foxp3+ Treg
    Pierre Milpied
    CNRS UMR 8147, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Hopital Necker, Paris, France
    Eur J Immunol 39:1466-71. 2009
    ..Neuropilin-1 (Nrp-1), a membrane protein primarily involved in the nervous system, was identified as a specific marker of murine Treg,..
  26. doi Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta
    Yelena Glinka
    Department of Laboratory Medicine and Keenan Research Center in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5B 1W8
    Carcinogenesis 32:613-21. 2011
    Neuropilin (Nrp)-1 and Nrp-2 are multifunctional proteins frequently expressed by cancer cells and contribute to tumor progression by mechanisms that are not well understood...
  27. pmc Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A
    V Castellani
    Laboratoire de Neurogenèse et Morphogenèse dans le Développement et chez l Adulte, UMR CNRS 6156, Universite de la Mediterranee, IBDM, Parc Scientifique de Luminy, 13288 Marseille Cedex 9, France
    EMBO J 21:6348-57. 2002
    ..A pathological L1 missense mutation located in this sequence specifically disrupts both L1-NP-1 complex formation and Sema3A reversion, suggesting that the cross-talk between L1 and Sema3A might participate in human brain development...
  28. ncbi Anti-chemorepulsive effects of vascular endothelial growth factor and placental growth factor-2 in dorsal root ganglion neurons are mediated via neuropilin-1 and cyclooxygenase-derived prostanoid production
    Lili Cheng
    Department of Medicine, The Rayne Institute, University College London, 5 University Street, London WC1E 6JJ, United Kingdom
    J Biol Chem 279:30654-61. 2004
    ..These findings support a specific role for NP-1 in mediating neurotrophic actions of VEGF family members and also identify a novel role for prostanoids in the inhibition of neuronal chemorepulsion...
  29. ncbi Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2
    David C West
    School of Biological Sciences, Biosciences Building, University of Liverpool, Liverpool, L69 7ZB, United Kingdom
    J Biol Chem 280:13457-64. 2005
    ..Npn-1 was also found to potentiate the growth stimulatory activity of FGF-2 on human umbilical vein endothelial cells, indicating that Npn-1 may not just bind but also regulate the activity of heparin-binding proteins...
  30. ncbi Neuron restrictive silencer factor NRSF/REST is a transcriptional repressor of neuropilin-1 and diminishes the ability of semaphorin 3A to inhibit keratinocyte migration
    Peter Kurschat
    Department of Surgery, Vascular Biology Program, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:2721-9. 2006
    ..It was concluded that NRSF is a transcription factor that silences NRP1 expression and thereby diminishes the Sema3A mediated inhibition of HaCaT keratinocyte migration...
  31. pmc Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A
    Masashi Narazaki
    Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive 12N226, Bethesda, MD 20892 1907
    Blood 107:3892-901. 2006
    ..These results demonstrate that preferential receptor binding and internalization by a ligand are mechanisms by which the common receptor Npn-1 can play an essential role in prioritizing conflicting signals...
  32. ncbi Interaction of vascular endothelial growth factor 165 with neuropilin-1 protects rheumatoid synoviocytes from apoptotic death by regulating Bcl-2 expression and Bax translocation
    Wan Uk Kim
    Department of Internal Medicine, Division of Rheumatology, School of Medicine, Catholic University of Korea, Seoul, Korea
    J Immunol 177:5727-35. 2006
    ....
  33. pmc Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A
    Masashi Narazaki
    The Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1907, USA
    Blood 111:4126-36. 2008
    ..with NRPs selects the specific signal transducer, plexins for semaphorins or VEGF receptors for VEGF, and promotes NRP internalization, which effectively shuts down receptor-mediated signaling by a second ligand...
  34. doi VEGF-A165 induces human aortic smooth muscle cell migration by activating neuropilin-1-VEGFR1-PI3K axis
    Snigdha Banerjee
    Stem Cell Research Laboratory, Cancer Research Unit, VA Medical Center, Kansas City, Missouri 64128, USA
    Biochemistry 47:3345-51. 2008
    ..smooth muscle cells (hAOSMCs), and this induction is mediated through a molecular cross-talk of neuropilin-1 (NRP-1), VEGFR1 (Flt-1), and phosphoinositide 3-kinase (PI3K)/Akt signaling kinase...
  35. pmc Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells
    Emely Castro-Rivera
    Departments of Internal Medicine, Hamon Center for Therapeutic Oncology Research Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Cancer Res 68:8295-303. 2008
    ..We conclude that SEMA3B is a potential tumor suppressor that induces apoptosis in SEMA3B-inactivated tumor cells through the Np-1 receptor by inactivating the Akt signaling pathway. CA118384..
  36. doi Advanced glycation end-products suppress neuropilin-1 expression in podocytes
    Tzvetanka Bondeva
    Klinik fur Innere Medizin III, Friedrich Schiller University, Jena, Germany
    Kidney Int 75:605-16. 2009
    ..The decreased migration could lead to adherence of uncovered areas of the glomerular basement membrane to Bowman's capsule contributing to focal glomerulosclerosis...
  37. doi Neuropilin-1 and neuropilin-2 are differentially expressed in human proteinuric nephropathies and cytokine-stimulated proximal tubular cells
    Herbert Schramek
    Department of Internal Medicine IV, Nephrology and Hypertension, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Lab Invest 89:1304-16. 2009
    ..This is the first report suggesting a differential role of NRP1 and NRP2 in renal fibrogenesis, and TGF-beta1, IL-1beta, and OSM represent the first ligands known to stimulate NRP2 expression in mammalian cells...
  38. ncbi PGF isoforms, PLGF-1 and PGF-2 and the PGF receptor, neuropilin, in human breast cancer: prognostic significance
    Astrid Escudero-Esparza
    Department of Surgery, Cardiff School of Medicine, Cardiff University, Cardiff, UK
    Oncol Rep 23:537-44. 2010
    ..Our study shows that PLGF isoforms PLGF-1 and PGF-2 and indeed their receptor neuopilin, have an aberrant pattern of expression and that high levels of the PLGF-1 and neuropilin are linked to a poor prognosis...
  39. ncbi Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III
    H Chen
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Neuron 19:547-59. 1997
    ..They also suggest that the specificity of action of different members of this subfamily may be determined by the complement of neuropilins expressed by responsive cells...
  40. ncbi Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    S Soker
    Department of Surgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 92:735-45. 1998
    ..This isoform-specific VEGF receptor (VEGF165R) is identical to human neuropilin-1, a receptor for the collapsin/semaphorin family that mediates neuronal cell ..
  41. ncbi Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity
    R J Giger
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    Neuron 21:1079-92. 1998
    ..These results provide insight into how interactions between neuropilins and secreted semaphorins function to coordinate repulsive axon guidance during neurodevelopment...
  42. ncbi Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins
    H Chen
    Department of Anatomy, Howard Hughes Medical Institute, University of California, San Francisco 94143, USA
    Neuron 21:1283-90. 1998
    ....
  43. ncbi Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors
    T Takahashi
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Neurosci 1:487-93. 1998
    ..SemA and SemE seem to have a newly discovered protein antagonist capacity at NP-1 receptors, whereas they act as agonists at receptors containing NP-2...
  44. ncbi Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively
    M Rossignol
    Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    Genomics 57:459-60. 1999
  45. ncbi Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1
    T Makinen
    Molecular Cancer Biology Laboratory, Haartman Institute, University of Helsinki, FIN 00014 Helsinki, Finland
    J Biol Chem 274:21217-22. 1999
    ....
  46. ncbi Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1
    H Cai
    Howard Hughes Medical Institutes, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 19:6519-27. 1999
    ..We suggest that NIP and GIPC may participate in regulation of Npn-1-mediated signaling as a molecular adapter that couples Npn-1 to membrane trafficking machinery in the dynamic axon growth cone...
  47. ncbi Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates
    L Tamagnone
    Institute for Cancer Research and Treatment, University of Torino, Candiolo, Italy
    Cell 99:71-80. 1999
    ..We conclude that plexins are receptors for multiple (and perhaps all) classes of semaphorins, either alone or in combination with neuropilins, and trigger a novel signal transduction pathway controlling cell repulsion...
  48. pmc Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity
    M L Gagnon
    Departments of Surgical Research, Pathology, and Urology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:2573-8. 2000
    Neuropilin-1 (NRP1) is a 130-kDa transmembrane receptor for semaphorins, mediators of neuronal guidance, and for vascular endothelial growth factor 165 (VEGF(165)), an angiogenesis factor. A 2...
  49. ncbi Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]
    Z Gluzman-Poltorak
    Department of Biology, Technion, Israel Institute of Technology, Haifa 32000, Israel
    J Biol Chem 275:18040-5. 2000
    ..Nevertheless, it is possible that VEGF-induced np-2-mediated signaling will take place only in the presence of other VEGF receptors such as VEGF receptor-1 or VEGF receptor-2...
  50. ncbi Plexina1 autoinhibition by the plexin sema domain
    T Takahashi
    Department of Neurology and, Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 29:429-39. 2001
    Semaphorin 3A (Sema3A) binds to neuropilin-1 (NP1) and activates the transmembrane Plexin to transduce a repulsive axon guidance signal...
  51. ncbi Vascular endothelial growth factor receptor-2 and neuropilin-1 form a receptor complex that is responsible for the differential signaling potency of VEGF(165) and VEGF(121)
    G B Whitaker
    Department of Cardiovascular Research, Procter and Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason Montgomery Road, Mason, Ohio 45040, USA
    J Biol Chem 276:25520-31. 2001
    ..Taken together, these data suggest a receptor-clustering role for Npn-1, as opposed to Npn-1 behaving as an affinity-converting subunit...
  52. ncbi A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response
    Rafaele Tordjman
    Institut Cochin, Departement d Hematologie, INSERM U567, CNRS UMR 8104, Paris, France
    Nat Immunol 3:477-82. 2002
    ..These data suggest that neuropilin-1 mediates interactions between DCs and T cells that are essential for initiation of the primary immune response and show parallels between the nervous and immune systems...
  53. ncbi Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain
    Roni Mamluk
    Department of Surgical Research, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:24818-25. 2002
    ....
  54. ncbi Neuropilin-1 is differentially expressed in myoepithelial cells and vascular smooth muscle cells in preneoplastic and neoplastic human breast: a possible marker for the progression of breast cancer
    John M Stephenson
    Cancer Research Unit, V A Medical Center, and Department of Internal Medicine, Division of Hematology and Oncology, University of Kansas Medical Center, Kansas City, MO, USA
    Int J Cancer 101:409-14. 2002
    The expression and distribution of neuropilin-1 (NRP-1) was examined in the samples of normal human breast tissues and in non-neoplastic and neoplastic areas of breast tissue removed for carcinoma using RT-PCR as well as conventional and ..
  55. ncbi Crystal structure of the human neuropilin-1 b1 domain
    Christian C Lee
    The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Structure 11:99-108. 2003
    ..The nature of the cell adhesion binding site of the b1 domain can be visualized in context of the structure...
  56. ncbi Characterization of the neuropilin-1 promoter; gene expression is mediated by the transcription factor Sp1
    Mireille Rossignol
    Institute of Signaling, Developmental Biology, and Cancer Research, CNRS UMR 6543, Centre Antoine Lacassagne, 06189 Nice, France
    J Cell Biochem 88:744-57. 2003
    ..It was concluded that NRP1 expression is regulated by the cooperation of several regulatory elements including AP-1, Sp1, and a CCAAT box...
  57. ncbi Differential expression of neuropilin-1 in malignant and benign prostatic stromal tissue
    Peter J VanVeldhuizen
    Cancer Research Unit, V A Medical Center, Research Division, Kansas City, MO 64128, USA
    Oncol Rep 10:1067-71. 2003
    Neuropilin-1 (NRP-1), a co-receptor for VEGF165, is overexpressed in various prostate cancer cell lines and in advanced prostate tumors. However, distribution of the NRP-1 in prostate tumors has not yet been evaluated...
  58. ncbi Aberrant expression of neuropilin-1 and -2 in human pancreatic cancer cells
    Kimi Fukahi
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of California, Irvine, California, USA
    Clin Cancer Res 10:581-90. 2004
    ..Neuropilin (Np)-1 and -2 are coreceptors for vascular endothelial growth factor (VEGF). This study was designed to assess their role in pancreatic ductal adenocarcinoma (PDAC)...
  59. ncbi Vascular endothelial growth factor (VEGF) receptor neuropilin-1's distribution in astrocytic tumors
    H Broholm
    Laboratory of Neuropathology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej, Denmark
    APMIS 112:257-63. 2004
    ..The results suggest a correlation between neuropilin-1 and vascularity in human astrocytic tumors and a possible role for neuropilin-1 as a receptor for VEGF-induced angiogenesis...
  60. ncbi Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability
    Patrice M Becker
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 96:1257-65. 2005
    ..These data support a critical role for Npn-1 in regulating endothelial barrier dysfunction in response to VEGF and suggest that activation of distinct receptor complexes may determine specificity of cellular response to VEGF...
  61. pmc Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells
    J S Wey
    Department of Surgical Oncology, Unit 444, The University of Texas, MD Anderson Cancer Center, PO Box 301402, Houston, TX 77230 1402, USA
    Br J Cancer 93:233-41. 2005
    Neuropilin-1 (NRP-1) is a novel co-receptor for vascular endothelial growth factor (VEGF). Neuropilin-1 is expressed in pancreatic cancer, but not in nonmalignant pancreatic tissue...
  62. ncbi Tuftsin binds neuropilin-1 through a sequence similar to that encoded by exon 8 of vascular endothelial growth factor
    Mathew A von Wronski
    Ernst Felder Laboratories, Bracco Research USA, 305 College Road East, Princeton, NJ 08540, USA
    J Biol Chem 281:5702-10. 2006
    ..Given the overlap between processes involving neuropilin-1 and tuftsin, we propose that at least some of the previously reported effects of tuftsin are mediated through neuropilin-1...
  63. ncbi Characterization of a bicyclic peptide neuropilin-1 (NP-1) antagonist (EG3287) reveals importance of vascular endothelial growth factor exon 8 for NP-1 binding and role of NP-1 in KDR signaling
    Haiyan Jia
    Centre for Cardiovascular Biology and Medicine, Department of Medicine and Ark Therapeutics Limited, The Rayne Institute, University College London, London WC1E 6JJ, United Kingdom
    J Biol Chem 281:13493-502. 2006
    ..The results also identify a key role for the C-terminal exon 8 domain in VEGF-A165 binding to NP-1...
  64. pmc Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry
    David Ghez
    CNRS UMR 8147, Universite Paris V, Assistance Publique Hopitaux de Paris, Hopital Necker, 161 rue de Sevres, 75743 Paris Cedex 15, France
    J Virol 80:6844-54. 2006
    ..These data show that NRP1 is involved in HTLV-1 and HTLV-2 entry, suggesting that the HTLV receptor has a multicomponent nature...
  65. pmc Immunolocalization and expression of vascular endothelial growth factor receptors (VEGFRs) and neuropilins (NRPs) on keratinocytes in human epidermis
    Xiao Yong Man
    Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, P R China
    Mol Med 12:127-36. 2006
    ..VEGF receptors (VEGFRs, including VEGFR-1, VEGFR-2, and VEGFR-3) and neuropilins (NRPs, including NRP-1 and NRP-2) are high-affinity receptors for VEGF and are typically considered to be specific for endothelial cells...
  66. ncbi Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth
    Qi Pan
    Tumor Biology and Angiogenesis, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Cancer Cell 11:53-67. 2007
    ..We propose that blocking NRP1 function inhibits vascular remodeling, rendering vessels more susceptible to anti-VEGF therapy...
  67. pmc Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions
    Yves Lepelletier
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 8147, Universite Rene Descartes Paris V, Hopital Necker, 75743 Paris, France
    Proc Natl Acad Sci U S A 104:5545-50. 2007
    ..In conclusion, we show here that NP-1/Sema-3A-mediated interactions participate in the control of human thymocyte development...
  68. pmc Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway
    B Hu
    University of Pittsburgh Cancer Institute and Department of Pathology, Pittsburgh, PA 15213 1863, USA
    Oncogene 26:5577-86. 2007
    ....
  69. ncbi Neuropilin-1 promotes unlimited growth of ovarian cancer by evading contact inhibition
    Tsukasa Baba
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, 54 Shogoinkawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Gynecol Oncol 105:703-11. 2007
    Neuropilin-1 (NRP-1) is a receptor for both semaphorin and vascular endothelial growth factor and is up-regulated in a variety of human cancers...
  70. ncbi Neuropilin-1 interacts with integrin beta1 and modulates pancreatic cancer cell growth, survival and invasion
    Mitsuharu Fukasawa
    Department of Medicine, Pharmacology and Toxicology, and the Norris Cotton Comprehensive Cancer Center, Hanover, New Hampshire New Hampshire, USA
    Cancer Biol Ther 6:1173-80. 2007
    ..Thus, Np-1 confers a growth and survival advantage to PANC-1 cells, and interacts with integrin beta1 to coordinate signaling events that promote cell adherence and invasiveness...
  71. ncbi Hepatocyte growth factor-mediated cell invasion in pancreatic cancer cells is dependent on neuropilin-1
    Arikira Matsushita
    Department of Medicine, Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Cancer Res 67:10309-16. 2007
    ..These findings indicate that Np-1 is required for efficient activation of c-Met-dependent pathways that promote cell invasiveness...
  72. ncbi Neuropilin-1 and neuropilin-2 act as coreceptors, potentiating proangiogenic activity
    Eric Sulpice
    Institut des Vaisseaux et du Sang, Centre de Recherche Cardiovasculaire Lariboisière Inserm U 689 Université Paris VII AP HP Lariboisière, Paris, France
    Blood 111:2036-45. 2008
    ..Our results suggest that, in endothelial cells, both NRP1 and NRP2 function as proangiogenic coreceptors, potentiating the activity of at least 2 major proangiogenic cytokines, VEGF-A(165) and HGF...
  73. pmc Neuropilin-1-VEGFR-2 complexing requires the PDZ-binding domain of neuropilin-1
    Claudia Prahst
    Joint Research Division Vascular Biology of the Medical Faculty Mannheim CBTM, University of Heidelberg
    J Biol Chem 283:25110-4. 2008
    ..Taken together, the experiments have identified a novel mechanism of NP-1 interaction with VEGFR-2, which involves the cytoplasmic domain of NP-1...
  74. pmc Chondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathway
    Paul Frankel
    Department of Medicine, Centre for Cardiovascular Biology and Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
    EMBO Rep 9:983-9. 2008
    b>Neuropilin 1 (NRP1), a non-tyrosine kinase receptor for vascular endothelial growth factor and class 3 Semaphorins, is highly expressed in many human tumour cell lines, but its function is poorly understood...
  75. pmc Neuropilin-1 upholds dedifferentiation and propagation phenotypes of renal cell carcinoma cells by activating Akt and sonic hedgehog axes
    Ying Cao
    Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Cancer Res 68:8667-72. 2008
    Expression of neuropilin-1 (NRP-1) has been shown in many cancer cells, but its molecular effect on tumorigenesis is largely unknown...
  76. pmc HTLV-1 uses HSPG and neuropilin-1 for entry by molecular mimicry of VEGF165
    Sophie Lambert
    Centre National de la Recherche Scientifique Unite Mixte de Recherche, INSERM U, Universite Paris Descartes, Institut Cochin, France
    Blood 113:5176-85. 2009
    ..Previously, our laboratories demonstrated that heparan sulfate proteoglycans (HSPGs) and neuropilin-1 (NRP-1), a receptor of VEGF(165), are essential for HTLV-1 entry...
  77. pmc C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration
    Tambet Teesalu
    Vascular Mapping Center, The Burnham Institute for Medical Research at University of California, Santa Barbara, CA 93106 9610, USA
    Proc Natl Acad Sci U S A 106:16157-62. 2009
    ..Affinity chromatography showed that the CendR peptides bind to neuropilin-1 (NRP-1) on the target cells...
  78. doi The role of neuropilins in cell signalling
    Ian C Zachary
    Centre for Cardiovascular Science and Medicine, University College London, 5 University Street, London WC1E 6JJ, UK
    Biochem Soc Trans 37:1171-8. 2009
    ..Growing evidence indicates, however, that NRP1 plays a selective role in signalling at least in part via its C-terminal domain and interaction with intracellular binding partners...
  79. pmc Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells
    Shumin Zhang
    Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
    Mol Cancer 9:9. 2010
    ..Mcl-1 overexpression has been associated with progression in leukemia and some solid tumors including prostate cancer (PCa). However, the regulatory mechanism for Mcl-1 expression in PCa cells remains elusive...
  80. pmc Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells
    Sheng Cao
    Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 120:2379-94. 2010
    ..Here, we found that in two rat models of liver fibrosis, the axonal guidance molecule neuropilin-1 (NRP-1) was upregulated in activated HSCs, which exhibit the highly motile myofibroblast phenotype...
  81. pmc Neuropilin-1 mediates divergent R-Smad signaling and the myofibroblast phenotype
    Ying Cao
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 285:31840-8. 2010
    ..Recently, neuropilin-1 (NRP-1) was reported to bind and activate the latent form of TGF-β1 (LAP-TGF-β1)...
  82. pmc Butyrate suppresses expression of neuropilin I in colorectal cell lines through inhibition of Sp1 transactivation
    Danny C W Yu
    Department of Oncology, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK
    Mol Cancer 9:276. 2010
    Neuropilin is a transmembrane receptor for vascular endothelial growth factor (VEGF) and is expressed in normal endothelial cells and upregulated in cancer cells...
  83. pmc Targeting neuropilin-1 in human leukemia and lymphoma
    Katja Karjalainen
    David H Koch Center, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Blood 117:920-7. 2011
    ..pathway, and we next identified the corresponding receptor as the transmembrane glycoprotein neuropilin-1 (NRP-1)...
  84. pmc Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells
    Ian M Evans
    UCL Division of Medicine, 5 University Street, London WC1E 6JJ, United Kingdom
    Mol Cell Biol 31:1174-85. 2011
    ....
  85. doi Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output
    Kurt Ballmer-Hofer
    Biomolecular Research, Molecular Cell Biology, Paul Scherrer Institute, Villigen, Switzerland
    Blood 118:816-26. 2011
    ..3 receptor tyrosine kinases (RTKs), VEGFR-1, -2, and -3, and by binding to coreceptors such as neuropilin-1 (NRP-1)...
  86. pmc VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation
    Birger Herzog
    BHF Laboratories, University College London, London WC1E 6JJ, UK
    Mol Biol Cell 22:2766-76. 2011
    ..Identification of key residues essential for VEGF binding and biological functions provides the basis for a rational design of antagonists of VEGF binding to NRP1...
  87. pmc The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins
    Alessandro Fantin
    UCL Institute of Ophthalmology, University College London, London EC1V 9EL, UK
    Development 138:4185-91. 2011
    b>Neuropilin 1 (NRP1) is a transmembrane glycoprotein that is essential for blood vessel development in vertebrates...
  88. doi Role of neuropilin-1 and its expression in Egyptian acute myeloid and acute lymphoid leukemia patients
    Sarah Younan
    Department of Clinical and Chemical Pathology, Kasr El Aini Hospital, Cairo University, El Saraya Street, Infront of El Manial Palace, Cairo 11451, Egypt
    Leuk Res 36:169-73. 2012
    ..Their expression is thought to be correlated with tumor angiogenesis and progression. In this study, we analyzed NRP-1 expression level in 40 acute leukemia patients [20 acute myeloid leukemia (AML) and 20 acute lymphoblastic ..
  89. doi Neuropilin-1 expression in cancer and development
    Adrian M Jubb
    Department of Pathology, Genentech Inc, South San Francisco, CA 94080, USA
    J Pathol 226:50-60. 2012
    Neuropilin (NRP)-1 is a co-receptor for vascular endothelial growth factor (VEGF)...
  90. doi Neuropilin-1 identifies a subset of bone marrow Gr1- monocytes that can induce tumor vessel normalization and inhibit tumor growth
    Alessandro Carrer
    Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    Cancer Res 72:6371-81. 2012
    ..We conclude that NEMs represent a novel, unique population of myeloid cells that, once inoculated into a tumor, induce tumor vessel normalization and inhibit tumor growth...
  91. ncbi The expression and significance of neuropilin-1 (NRP-1) on glioma cell lines and glioma tissues
    Lukui Chen
    Department of Neurosurgery, Zhongda Hospital Southeast University, Nanjing, 210009, China
    J Biomed Nanotechnol 9:559-63. 2013
    We detected the expressions of neuropilin-1 (NRP-1) on glioma cell lines and glioma tissues by neuropilin-1 monoclonal antibody (NRP-1 MAb)...
  92. pmc The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis
    Anthony Lanahan
    Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, USA
    Dev Cell 25:156-68. 2013
    b>Neuropilin 1 (NRP1) plays an important but ill-defined role in VEGF-A signaling and vascular morphogenesis...
  93. doi Neuropilin-1 expression promotes invasiveness of melanoma cells through vascular endothelial growth factor receptor-2-dependent and -independent mechanisms
    Federica Ruffini
    Laboratory of Molecular Oncology, Istituto Dermopatico dell Immacolata IRCCS, I 00167 Rome, Italy
    Int J Oncol 43:297-306. 2013
    ..vascular endothelial growth factor-A (VEGF-A) and expresses its receptors VEGFR-1, VEGFR-2 and neuropilin-1 (NRP‑1), a co-receptor for VEGF-A that amplifies the signalling through VEGFR-2...
  94. doi miR-320 regulates tumor angiogenesis driven by vascular endothelial cells in oral cancer by silencing neuropilin 1
    Yi Ying Wu
    Graduate Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan
    Angiogenesis 17:247-60. 2014
    ..b>Neuropilin 1 (NRP1), an important regulator of angiogenesis, was found to be a target of miR-320...
  95. pmc Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis
    Alessandro Fantin
    UCL Institute of Ophthalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK
    Development 141:556-62. 2014
    b>Neuropilin 1 (NRP1) is a receptor for class 3 semaphorins and vascular endothelial growth factor (VEGF) A and is essential for cardiovascular development...
  96. pmc MicroRNA-338 inhibits growth, invasion and metastasis of gastric cancer by targeting NRP1 expression
    Yang Peng
    Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
    PLoS ONE 9:e94422. 2014
    ..miR-338 can decrease migratory, invasive, proliferative and apoptotic behaviors, as well as gastric cancer EMT, by attenuating the expression of NRP1. ..
  97. pmc Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis
    Alexander A Parikh
    Departments of Surgical Oncology and Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Am J Pathol 164:2139-51. 2004
    Neuropilin-1 (NRP-1), a recently identified co-receptor for vascular endothelial growth factor, is expressed by several nongastrointestinal tumor types and enhances prostate cancer angiogenesis and growth in preclinical models...
  98. ncbi Breast cancer cells secreted platelet-derived growth factor-induced motility of vascular smooth muscle cells is mediated through neuropilin-1
    Snigdha Banerjee
    Cancer Research Unit, VA Medical Center, Kansas City, Missouri 64128, USA
    Mol Carcinog 45:871-80. 2006
    ..PDGF significantly upregulates neuropilin-1 (NRP-1) mRNA expression and protein production in aortic smooth muscle cells (AOSMCs) and depletion of NRP-1 production ..
  99. pmc Neuropilin, you gotta let me know: should I stay or should I go?
    Quenten Schwarz
    UCL Institute of Ophthalmology, London, UK
    Cell Adh Migr 4:61-6. 2010
    ..Here, we review how the developmental functions of the neuropilins are influenced by such different contexts...
  100. ncbi The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1
    G Fuh
    Department of Protein Engineering, Genentech Inc, South San Francisco, California 94080, USA
    J Biol Chem 275:26690-5. 2000
    ..Furthermore, Flt-1 may function as a negative regulator of angiogenesis by competing for NP-1...
  101. doi Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells
    S H Hsieh
    Institute of Oral Medicine, National Cheng Kung University, College of Medicine, Tainan, Taiwan
    Oncogene 27:3746-53. 2008
    ..These findings show, for the first time, that Gal-1 can directly bind to NRP1 on endothelial cells, and can promote the NRP1/VEGFR-2-mediated signaling pathway as well as NRP1-mediated biological activities...

Research Grants62

  1. ANNE CHRISTINE EICHMANN; Fiscal Year: 2015
    ..We will investigate the role of Neuropilin 1 and 2 (Nrp1, 2), co-receptors for vascular endothelial growth factors (VEGFs) and class III Semaphorins (Sema3),..
  2. MUC1 enhances Neuropilin-1 signaling in pancreatic ductal adenocarcinoma
    Pinku Mukherjee; Fiscal Year: 2013
    ..recently found that pancreatic cancer cells and tumors expressing high MUC1 have increased levels of neuropilin-1 (NRP-1), a co-receptor of VEGFA as compared to PDA with no or low MUC1...
  3. Joseph H McCarty; Fiscal Year: 2016
    ..Characterizing these pathways will be an important first step toward designing new therapies to target invasive cells. ..
  4. Tobias Meyer; Fiscal Year: 2014
    ..Using high-throughput RNAi screening, we identified Neuropilins (Nrp) 1 and 2 as novel, specific regulators of vertebrate Hh signaling...
  5. Fox Transcription Factors in Vascular Development
    Tsutomu Kume; Fiscal Year: 2012
    ..VEGF-A signaling activates the Notch-Delta like 4 (Dll4) pathway and induces expression of Neuropilin 1 (Nrp1), a co-receptor for VEGF-A, to promote the arterial program...
  6. Susan J Fisher; Fiscal Year: 2016
    ..g., a subset of the dysregulated molecules could be circulating biomarkers and/or therapeutic targets for improving placental function, which our data suggest is possible. ..
  7. Michael Simons; Fiscal Year: 2016
    ..vascular structures with arterial identity as defined by expression of key markers such ephrin 82 and neuropilin 1 followed by acquisition of the media and adventitia...
  8. Signaling Mechanisms mediating effects of Semaphorin3A
    Zhigang He; Fiscal Year: 2005
    ....
  9. Effects of Semaphorin 3A on Stroke Recovery
    Klaus van Leyen; Fiscal Year: 2013
    ..In Aim 2, we study the expression of Sema3A and its receptor Neuropilin 1 (NRP1), in a mouse model of middle cerebral artery occlusion (MCAO)...
  10. MECHANISMS OF BREAST CARCINOMA SURVIVAL
    Arthur M Mercurio; Fiscal Year: 2010
    ..For this reason, a rigorous understanding of the mechanisms used in this signaling and its relevance to breast cancer is essential. ..
  11. Peter Y Lwigale; Fiscal Year: 2016
    ....
  12. Computational Design of Small Molecule Drugs Inhibiting the Zinc Finger Transcrip
    David Sherris; Fiscal Year: 2010
    ..Work from this project will further advance our knowledge on zinc finger protein transcription factor/DNA interactions and may thus open the door to a whole new range of therapeutic agents. ..
  13. GERARD ANTHONY LUTTY; Fiscal Year: 2014
    ....
  14. Karl Degenhardt; Fiscal Year: 2014
    ..The data obtained in the course of the proposed research will provide insights into normal and abnormal pulmonary venous patterning, semaphorin signaling, and the genetic roots of congenital heart disease. ..
  15. Lois Smith; Fiscal Year: 2014
    ..Neuronal guidance cues, Semaphorins (Sema) and their receptor Neuropilin (Nrp) might be shared with vessels to direct this misguided growth. Nrp-1 binds opposing factors Sema3A and VEGF...
  16. Vijay H Shah; Fiscal Year: 2016
    ..Our preliminary data demonstrate that protein levels of the proteoglycan neuropilin-1 (NRP) are increased in both humans and animals with alcohol and non-alcohol induced liver fibrosis and promotes FN ..
  17. High-throughput screen to identify modulators of CendR-mediated cellular uptake
    Erkki Ruoslahti; Fiscal Year: 2013
    ..The screens may also yield antagonists of the CendR system, which could be useful in inhibiting the transport of toxins and infectious agents through the CendR transport system. ..
  18. Neuropilin and semaphorin, anti-angiogenesis activities and mechanisms
    Michael Klagsbrun; Fiscal Year: 2009
    ..This proposal focuses on identifying potentially novel angiogenesis inhibitors based on neuropilin (NRP) and semaphorin (SEMA) structure and function...
  19. Kazuki Sugahara; Fiscal Year: 2016
    ..motif and a CendR motif (R/KXXR/K) that mediates tissue and cell penetration through binding to neuropilin-1 (NRP-1)...
  20. Role of Interleukin-16 in asthma
    David Center; Fiscal Year: 2009
    ..Demonstrating the function of IL-16 responsive T regulatory cells by introducing them in vivo in a mouse model of antigen-induced inflammation. ..
  21. ROLE OF VEGF AND NRP 1 IN ESTROGEN INDUCED ANGIOGENESIS
    Sushanta Banerjee; Fiscal Year: 2002
    ..positive angiogenic factor, called the vascular endothelial growth factor (VEGF) and its co-receptor neuropilin-1 (NRP-1) in the cellular and molecular sequence of events by which estrogens produce tumor angiogenesis in the rat ..
  22. Debabrata Mukhopadhyay; Fiscal Year: 2016
    ..Nonetheless, our preliminary data suggest a novel function of VEGF on tumor cells via NRP-1 and that leads to generate a new hypothesis that VEGF/NRP-1 axis can play an important role to maintain the tumor ..
  23. Karen J Colley; Fiscal Year: 2015
    ..recent identification of two of these polyST substrates, SynCAM 1, a synaptic adhesion molecule, and neuropilin-2 (NRP-2), a semaphorin and VEGF co-receptor, suggests that the roles of polySia may be more extensive than previously ..
  24. Volkmar Heinrich; Fiscal Year: 2015
    ..this application puts forward the paradigm that serial linkages of the form extracellular ligand - transmembrane receptor - cytoskeletal anchor - cortical actin represent functional units that act as key biophysical switchboards ..
  25. Samuel L Pfaff; Fiscal Year: 2014
    ..This grant aims to establish sufficient preliminary data to justify further investigation of VEGF as a feasible and novel treatment for CMT2D. ..
  26. Thomas L Clemens; Fiscal Year: 2016
    ..These functions were accomplished by the actions of multiple related ligands that activated a common transmembrane receptor protein...
  27. Relating GPCRs by biased ligands for enhanced therapeutic efficacy
    MICHAEL JAMES KEISER; Fiscal Year: 2013
    ..Aim 1: To predict and test new arrestin-biased ligands. Biased ligands are thought to stabilize transmembrane receptor conformational ensembles to preferentially activate a signaling pathway;in practice however we must more ..
  28. Steven L Gonias; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Low density lipoprotein receptor-related protein-1 (LRP-1) is a transmembrane receptor that mediates the endocytosis of over forty distinct ligands and other plasma membrane proteins...
  29. DAVID PAUL TURNER; Fiscal Year: 2014
    ..RAGE is an oncogenic transmembrane receptor which promotes inflammatory responses...
  30. Louis B Justement; Fiscal Year: 2014
    ..TLT2 is a transmembrane receptor that is expressed on neutrophils, monocytes/macrophages and B cells...
  31. MOLECULAR GENETICS OF CNS DEVELOPMENT
    KAI G ZINN; Fiscal Year: 2013
    ..neuronal cell surface/signal transduction proteins that we have been studying for many years: the transmembrane receptor tyrosine phosphatases (RPTPs)...
  32. Iris Z Jaffe; Fiscal Year: 2016
    ..is known to promote vascular cell proliferation, monocyte chemotaxis, and inflammation by binding to the transmembrane receptor, fms-like tyrosine kinase (Flt-1)...
  33. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Quentin J Baca; Fiscal Year: 2010
    ..David Golan's lab studying transmembrane receptor mobility. This will be the subject of his PhD thesis work...
  34. Xi He; Fiscal Year: 2016
    ..One is a member of the Frizzled (Fz) family of serpentine receptors, while the other is a single transmembrane receptor belonging to the LDL receptor related protein (LRP) family, LRP5 or LRP6...
  35. Role of CD3delta in T-lymphocyte function
    Batu Erman; Fiscal Year: 2011
    ..The TCR is a transmembrane receptor which has multiple signaling subunits...
  36. Robert J Lefkowitz; Fiscal Year: 2016
    ..provided by applicant): All aspects of cardiovascular function are regulated by receptors of the seven transmembrane receptor (7TMR) family...
  37. Paul Feinstein; Fiscal Year: 2014
    ..The mammalian genome consists of ~1500 OR genes;these genes belong to the seven-transmembrane receptor superfamily...
  38. Role of APP-related Proteins During Neuronal Migration
    Philip F Copenhaver; Fiscal Year: 2010
    ..A variety of studies in vitro have indicated that APP can act as a transmembrane receptor capable of regulating neuronal migration and outgrowth via several candidate intracellular signaling ..
  39. Effects of Sema3A-Nrp1 signaling on tumor cell extravastion and metastasis
    LISETTE MARIE ACEVEDO; Fiscal Year: 2013
    ..Understanding how mediators of vascular permeability can affect tumor extravasation and metastasis is required to design novel approaches to control metastatic disease. ..
  40. NITRIC OXIDE INTERACTION WITH INSECT NITROPHORINS
    FRANCES ANN WALKER; Fiscal Year: 2012
    ..Specific aims for the next grant period are: 1) To investigate NP4 and the native terminus-containing constructs of NP1, NP2 and NP3 or their X1A mutants, in which the recombinantly-produced proteins'Met0s are cleaved...
  41. Robert B Abramovitch; Fiscal Year: 2014
    ..bacterium and drives Mtb to realign its gene expression and physiology to support a non-replicative, persistent (NRP) state...
  42. Pasi A Janne; Fiscal Year: 2016
    ..RET is transmembrane receptor tyrosine kinase that is normally expressed in cells derived from neural crest and the urogenital tract...
  43. L Darryl Quarles; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Pkd1 encodes PC1, a transmembrane receptor-like protein, and Pkd2 encodes PC2, a calcium channel, which interact to form functional polycystin complexes that are widely expressed in many tissues and ..
  44. Sarah J Ratcliffe; Fiscal Year: 2016
    ..Trial results will impact ILCOR and NRP guidelines...
  45. Richard B Cooley; Fiscal Year: 2014
    ..One such conserved c-di-GMP sensing system is the LapD/LapG system. LapD is a transmembrane receptor that regulates the activity of the periplasmic cysteine protease LapG by sensing cytoplasmic c-di-GMP ..
  46. Neurotrophin Protection of Hypoxic Ischemic Brain Injury
    Mir Ahamed Hossain; Fiscal Year: 2013
    ..of HI brain injury based on our new and exciting findings during the last funding period that neuronal pentraxin I (NP1), a member of a subfamily of "long pentraxins", is induced in HI brain injury...
  47. MYCOBACTERIUM TUBERCULOSIS REPLICATION AND PROLIFERATION
    Murty V Madiraju; Fiscal Year: 2012
    ..to virulence of Mtb is its intrinsic slow growth rate and the ability to maintain a non-replicative persistent (NRP) state...
  48. Development of Animal Models of Anti-MuSK Myasthenia
    David P Richman; Fiscal Year: 2011
    ..characterized by fatigable weakness, muscle wasting and circulating antibodies (Abs) to MuSK, a transmembrane receptor kinase crucial to the formation of this synapse...
  49. Targeting the Fn14-Rac1 signaling pathway in invasive gliomas
    Nhan L Tran; Fiscal Year: 2012
    ..Preliminary studies demonstrate that the transmembrane receptor, Fn14, is upregulated with glioma progression;Fn14 expression correlates inversely with poor patient ..
  50. Small Molecule Inhibitors of Malate Synthase against M. Tuberculosis
    Pavel A Petukhov; Fiscal Year: 2010
    ..in relapse rates lies in the specific targeting of proteins that are essential to the non-replicating persistence (NRP) of Mycobacterium tuberculosis. One such target is malate synthase (MS)...
  51. Role of Macrophage Migration Inhibitory Factor in Osteoclastogenesis
    Sun Kyeong Lee; Fiscal Year: 2013
    ..Hypotheses to be tested in this application are: 1) MIF signals cooperatively through the CD74 and CD44 transmembrane receptor proteins to regulate osteoclastogenesis, 2) MIF decreases the number of osteoclast precursor cells and/or ..
  52. Parvovirus RNA Processing and Gene Expression Strategies
    David J Pintel; Fiscal Year: 2013
    ..of canines (MVC) contains a potent internal polyadenylation site, and we have recently discovered that the MVC NP1 protein is essential for the accumulation in the cytoplasm of partially-processed MVC capsid gene mRNAs that retain ..
  53. Canonical Wnt Signaling by the Proteolytc Processing of LRP6
    BRANDON RICHARD BEAGLE; Fiscal Year: 2010
    ..Low-density lipoprotein (LDL) receptor-related protein 6 (LRP6) is a single pass transmembrane receptor that functions as a required co-receptor in the Wnt canonical pathway and whose inhibition in the pathway ..
  54. Wnt/beta-catenin signaling: phosphorylation regulation of Wnt receptor-Axin inter
    Xi He; Fiscal Year: 2013
    ..One is a member of the Frizzled (Fz) family of serpentine receptors, and the other is a single-pass transmembrane receptor of the LDL receptor related protein (LRP) family, LRP5 or LRP6...
  55. NARP AND GLUTAMATE RECEPTOR CLUSTERING
    Paul F Worley; Fiscal Year: 2012
    ..which supports our studies of Narp (Neuronal activity-regulated pentraxin) and related neural pentraxins including NP1 and NPR...
  56. Regulation of Mycobacterium tuberculosis proliferation
    Murty Madiraju; Fiscal Year: 2009
    ..rn virulence factor. with membranes and the ability of DnaA to initiate replication depends, promote NRP state in vivo are largely unknown. Our proposal focuses on DNA replication...
  57. Role of FHL-mediated formate metabolism in Mycobacterium tuberculosis persistence
    Thomas C Zahrt; Fiscal Year: 2013
    ..tuberculosis into an altered physiological state of nonreplicating persistence (NRP)...
  58. Lucia R Languino; Fiscal Year: 2015
    ..in the second specific aim, with emphasis on dynamic redistribution of b1 integrins by Trop-2, a transmembrane receptor that is up-regulated in prostate cancer, in specialized subcellular microdomains of prostate cancer cells...
  59. Functions and mechanisms of M. tuberculosis S/T kinases
    THOMAS C ALBER; Fiscal Year: 2012
    ..This research has four specific aims: 1. Define the basis for signaling through Mtb transmembrane receptor kinases. 2. Discover networks of kinase cross-phosphorylation and regulation. 3...
  60. Kris Steinbrecher; Fiscal Year: 2014
    ..applicant): Guanylin and uroguanylin are peptides that are expressed at mucosal surfaces and bind to the transmembrane receptor guanylate cyclase C (GC-C)...
  61. STEPHANIE CHEE YEE TJEN-A-LOOI; Fiscal Year: 2016
    ..to the midbrain ventrolateral periaqueductal gray (vlPAG) to the medullary midline nucleus raphe'pallidus (NRP) and then the rostral ventrolateral medulla (rVLM) where the activity of premotor sympathetic neurons is inhibited ..
  62. Biosynthesis of Antifungal Lipopeptides from Filamentous Fungi
    Yi Tang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Nonribsomal peptide (NRP) natural products biosynthesized by nonribosomal peptide synthetases (NRPSs) are among the most important therapeutics known to mankind, including penicillin, vancomycin and ..