NETO2

Summary

Gene Symbol: NETO2
Description: neuropilin and tolloid like 2
Alias: BTCL2, NEOT2, neuropilin and tolloid-like protein 2, brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2, neuropilin (NRP) and tolloid (TLL)-like 2
Species: human

Top Publications

  1. ncbi A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain
    Heidi Stohr
    Institut fur Humangenetik, Biozentrum, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Gene 286:223-31. 2002
  2. pmc Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking
    Nengyin Sheng
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A . 2017
  3. doi Pharmacological Modulation of GluK1 and GluK2 by NETO1, NETO2, and PSD95
    Baolin Li
    1 Neuroscience Discovery, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana
    Assay Drug Dev Technol 14:131-43. 2016
  4. doi Neto2 Influences on Kainate Receptor Pharmacology and Function
    Liwei Han
    Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 119:141-8. 2016
  5. pmc Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1
    Nengyin Sheng
    Deparment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States
    elife 4:. 2015
  6. pmc Upregulation of NETO2 expression correlates with tumor progression and poor prognosis in colorectal carcinoma
    Liang Hu
    Anal Colorectal Surgery Institute, 150th Hospital of PLA, Luoyang, China
    BMC Cancer 15:1006. 2015
  7. pmc Kainate receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanism
    Patricia M G E Brown
    Integrated Program in Neurosciences, McGill University, Montreal, Quebec, Canada, H3G 0B1
    J Physiol 594:1821-40. 2016
  8. pmc Identification of critical functional determinants of kainate receptor modulation by auxiliary protein Neto2
    Theanne N Griffith
    Department of Pharmacology, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Chicago, IL, 60611, USA
    J Physiol 593:4815-33. 2015
  9. pmc The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors
    Janet L Fisher
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC, 29208, USA Electronic address
    Neuropharmacology 99:471-80. 2015
  10. doi Synaptic Targeting of Kainate Receptors
    Jon Palacios-Filardo
    Instituto de Neurociencias CSIC UMH, 03550 San Juan de Alicante, Spain
    Cereb Cortex 26:1464-72. 2016

Research Grants

  1. Susumu Tomita; Fiscal Year: 2014
  2. Single Channel Properties and Structure of Glutamate Receptors
    James R Howe; Fiscal Year: 2012
  3. Genomic analysis of RNA binding protein target specificity
    JEREMY ROBERT SANFORD; Fiscal Year: 2010

Patents

  1. Primers for synthesizing full length cDNA clones and their use
  2. Compositions and methods for the treatment of immune related diseases

Scientific Experts

  • Susumu Tomita
  • Christine E Horak
  • Jeremy Sanford
  • Janet L Fisher
  • James R Howe
  • Man Tang
  • Nengyin Sheng
  • Michael W Salter
  • Roderick R McInnes
  • Bryan A Copits
  • Geoffrey T Swanson
  • Christoph Straub
  • Wei Zhang
  • Liwei Han
  • Baolin Li
  • Roger A Nicoll
  • Patricia M G E Brown
  • Jon Palacios-Filardo
  • Liang Hu
  • Theanne N Griffith
  • Megan S Wyeth
  • Caitlin Rippey
  • Evgueni A Ivakine
  • Kenneth A Pelkey
  • Chris J McBain
  • Vivek Mahadevan
  • David Ng
  • Evgueni Ivakine
  • Monica L Calicchio
  • Yun Stone Shi
  • Philip C Biggin
  • Juan Lerma
  • He Wang
  • Yuewei Qian
  • Elizabeth Rex
  • David Bleakman
  • Maria Musgaard
  • Derek Bowie
  • Mark R P Aurousseau
  • Ann Marie Ogden
  • Darryl S Pickering
  • M Isabel Aller
  • Kirk W Johnson
  • Chen Ye Qi
  • Yun S Shi
  • Chun fang Gao
  • Richa Madan Lomash
  • Yan Xia Zhai
  • Dan Feng
  • Jian Cai
  • Katherine W Roche
  • Hai yang Chen
  • Yu Zhang
  • Hui Gong
  • Hao Fu
  • Qing Ping Cai
  • Guang Zhen Yang
  • Ronald S Petralia
  • Heidi Stohr
  • Niklas Krumm
  • Bradley P Coe
  • Michelle Y Huang
  • Molly Gasperini
  • Jon M McClellan
  • Jake Ormond
  • Matt Brodsky
  • Ming K Lee
  • Tom Walsh
  • Mary Claire King
  • Melanie A Woodin
  • Eric Delpire
  • Suleyman Gulsuner
  • Jonathan Sebat
  • Sarah Pierce
  • Alex S Nord
  • Jessica C Pressey
  • Brooke A Acton
  • Cailyn Spurrell
  • Shanti Frausto
  • John S Robbins
  • Fannie St-Gelais
  • Jonathan C Trinidad
  • Harry P Kozakewich
  • Alma L Burlingame
  • Tucker Collins
  • Kwang S Kim
  • Akio Sumioka
  • Chad P Grabner
  • Megumi Morimoto-Tomita
  • Bernhard H F Weber

Detail Information

Publications25

  1. ncbi A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain
    Heidi Stohr
    Institut fur Humangenetik, Biozentrum, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Gene 286:223-31. 2002
    ..deduced amino acid sequence of a non-annotated nucleotide sequence in the GenBank database, therefore designated NETO2. Both NETO1 and NETO2 share an identical and unique domain structure thus representing a novel subfamily of CUB- ..
  2. pmc Amino-terminal domains of kainate receptors determine the differential dependence on Neto auxiliary subunits for trafficking
    Nengyin Sheng
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A . 2017
    ..contrast to GluK1, traffics to the neuronal surface and synapse efficiently and the auxiliary subunits Neto1 and Neto2 caused no further enhancement of these two trafficking processes...
  3. doi Pharmacological Modulation of GluK1 and GluK2 by NETO1, NETO2, and PSD95
    Baolin Li
    1 Neuroscience Discovery, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana
    Assay Drug Dev Technol 14:131-43. 2016
    ..GluK1 and GluK2 and the modifying proteins neuropilin- and tolloid-like 1 (NETO1), neuropilin- and tolloid-like 2 (NETO2), and postsynaptic density protein 95 (PSD95) is likely to produce distinct GluK1 and GluK2 pharmacology in ..
  4. doi Neto2 Influences on Kainate Receptor Pharmacology and Function
    Liwei Han
    Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 119:141-8. 2016
    Neuropilin tolloid-like protein 2 (Neto2) is an auxiliary subunit of kainate receptors (KARs)...
  5. pmc Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1
    Nengyin Sheng
    Deparment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States
    elife 4:. 2015
    ..Both Neto1 and Neto2 profoundly increase GluK1 surface expression and also drive GluK1 to synapses...
  6. pmc Upregulation of NETO2 expression correlates with tumor progression and poor prognosis in colorectal carcinoma
    Liang Hu
    Anal Colorectal Surgery Institute, 150th Hospital of PLA, Luoyang, China
    BMC Cancer 15:1006. 2015
    Neuropilin and tolloid-like 2 (NETO2) has been found to be overexpressed in different human cancers, but its expression pattern and clinical relevance in colorectal carcinoma (CRC) remains unknown.
  7. pmc Kainate receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanism
    Patricia M G E Brown
    Integrated Program in Neurosciences, McGill University, Montreal, Quebec, Canada, H3G 0B1
    J Physiol 594:1821-40. 2016
    Kainate receptor heteromerization and auxiliary subunits, Neto1 and Neto2, attenuate polyamine ion-channel block by facilitating blocker permeation...
  8. pmc Identification of critical functional determinants of kainate receptor modulation by auxiliary protein Neto2
    Theanne N Griffith
    Department of Pharmacology, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Chicago, IL, 60611, USA
    J Physiol 593:4815-33. 2015
    ..KARs associate with the auxiliary proteins neuropilin- and tolloid-like 1 and 2 (Neto1 and Neto2), which act as allosteric modulators of receptor function impacting all biophysical properties of these receptors ..
  9. pmc The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors
    Janet L Fisher
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC, 29208, USA Electronic address
    Neuropharmacology 99:471-80. 2015
    ..These receptors are also modulated by co-assembly with the auxiliary subunits Neto1 and Neto2. To determine the impact of variation in subunit composition on the functional interaction between kainate ..
  10. doi Synaptic Targeting of Kainate Receptors
    Jon Palacios-Filardo
    Instituto de Neurociencias CSIC UMH, 03550 San Juan de Alicante, Spain
    Cereb Cortex 26:1464-72. 2016
    ..We found that the GluK5 KAR subunit and the ancillary proteins, Neto1 and Neto2, are not expressed by hippocampal neurons in culture...
  11. pmc Neto auxiliary protein interactions regulate kainate and NMDA receptor subunit localization at mossy fiber-CA3 pyramidal cell synapses
    Megan S Wyeth
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, msc 3715, Bethesda, Maryland 20892, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, MSC 8027, Bethesda, Maryland 20892, Program in Neurosciences and Mental Health, Hospital for Sick Children, and Department of Physiology, University of Toronto, Toronto, Ontario M5G 1X8, Canada, and Lady Davis Research Institute, Jewish General Hospital and Departments of Human Genetics and Biochemistry, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Neurosci 34:622-8. 2014
    Neto1 and Neto2 auxiliary subunits coassemble with NMDA receptors (NMDARs) and kainate receptors (KARs) to modulate their function...
  12. pmc Neto2 is a KCC2 interacting protein required for neuronal Cl- regulation in hippocampal neurons
    Evgueni A Ivakine
    Program in Developmental and Stem Cell Biology, Hospital for Sick Children Research Institute, Toronto, ON, Canada M5G 1X8
    Proc Natl Acad Sci U S A 110:3561-6. 2013
    ..we show that KCC2 is critically regulated by the single-pass transmembrane protein neuropilin and tolloid like-2 (Neto2)...
  13. pmc Formation of chimeric genes by copy-number variation as a mutational mechanism in schizophrenia
    Caitlin Rippey
    Departments of Medicine and of Genome Sciences, University of Washington, Seattle, WA 98195, USA Electronic address
    Am J Hum Genet 93:697-710. 2013
    ..MATK and ZFR2, a 58 kb duplication disrupted PLEKHD1 and SLC39A9, a 121 kb duplication disrupted DNAJA2 and NETO2, and a 150 kb deletion disrupted MAP3K3 and DDX42...
  14. pmc Modulation of homomeric and heteromeric kainate receptors by the auxiliary subunit Neto1
    Janet L Fisher
    J L Fisher USC School of Medicine, Department of Pharmacology, Physiology and Neuroscience, 6439 Garners Ferry Road, Columbia, SC 29209, USA
    J Physiol 591:4711-24. 2013
    ..The neuropilin and tolloid-like 1 and 2 proteins (Neto1 and Neto2) have been recently identified as auxiliary subunits for kainate-type glutamate receptors...
  15. pmc Neto2 interacts with the scaffolding protein GRIP and regulates synaptic abundance of kainate receptors
    Man Tang
    Program in Developmental and Stem Cell Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    PLoS ONE 7:e51433. 2012
    ..We have previously identified the single-pass transmembrane proteins, Neto1 and Neto2, to be associated with native KARs...
  16. pmc The auxiliary subunits Neto1 and Neto2 reduce voltage-dependent inhibition of recombinant kainate receptors
    Janet L Fisher
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, South Carolina 29208, USA
    J Neurosci 32:12928-33. 2012
    ..In neurons, kainate receptors can associate with the auxiliary subunits Neto1 or Neto2. These transmembrane proteins alter the trafficking, channel kinetics, and pharmacology of the receptors in a ..
  17. pmc Dancing partners at the synapse: auxiliary subunits that shape kainate receptor function
    Bryan A Copits
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nat Rev Neurosci 13:675-86. 2012
    ..Recently, however, the neuropilin and tolloid-like 1 (NETO1) and NETO2 proteins were identified as auxiliary kainate receptor subunits that shape both the biophysical properties and ..
  18. pmc Neto1 and Neto2: auxiliary subunits that determine key properties of native kainate receptors
    Susumu Tomita
    Program in Cellular Neuroscience, Neurodegeneration and Repair CNNR, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Physiol 590:2217-23. 2012
    ..New research has identified Neto1 and Neto2 as KAR auxiliary subunits that determine unique properties of synaptic KARs, including their slow kinetics and ..
  19. pmc Neto1 is an auxiliary subunit of native synaptic kainate receptors
    Man Tang
    Program in Developmental and Stem Cell Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Neurosci 31:10009-18. 2011
    ..In contrast, the loss of Neto2, which also localizes to stratum lucidum and interacts with KARs, had no effect on KAR synaptic abundance or MF-..
  20. pmc Neto2 modulation of kainate receptors with different subunit compositions
    Christoph Straub
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 31:8078-82. 2011
    ..We recently identified Neuropilin and Tolloid like-2 (Neto2) as a novel accessory subunit of kainate receptors and showed that Neto2 modulates the gating kinetics of GluK2 ..
  21. pmc Synaptic targeting and functional modulation of GluK1 kainate receptors by the auxiliary neuropilin and tolloid-like (NETO) proteins
    Bryan A Copits
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 31:7334-40. 2011
    ..The neuropilin and tolloid-like proteins (NETO) 1 and NETO2, two closely related CUB domain-containing integral membrane proteins, were identified recently as auxiliary ..
  22. pmc Identification of signaling systems in proliferating and involuting phase infantile hemangiomas by genome-wide transcriptional profiling
    Monica L Calicchio
    Department of Pathology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Am J Pathol 174:1638-49. 2009
    ..JAG1), and notch-4 (NOTCH4), as well as genes involved in neural and vascular patterning, such as neuropilin-2 (NETO2), a plexin domain containing receptor (plexinC1), and an ephrin receptor (EPHB3)...
  23. pmc A transmembrane accessory subunit that modulates kainate-type glutamate receptors
    Wei Zhang
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuron 61:385-96. 2009
    ..Using a proteomic screen, we have identified NETO2, a brain-specific protein of unknown function, as an interactor with kainate-type glutamate receptors...
  24. pmc Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF
    Jeremy R Sanford
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    PLoS ONE 3:e3369. 2008
    ..of SF2/ASF regulates the splicing and polysome association of transcripts derived from the SFRS1, PABC1, NETO2 and ENSA genes...
  25. ncbi Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2
    Christine E Horak
    Women s Cancer Section, Laboratory of Molecular Pharmacology, National Cancer Institute NIH, 37 Convent Drive, Bethesda, MD 20892, USA
    Cancer Res 67:7238-46. 2007
    ..Nine genes, MET, PTN, SMO, FZD1, L1CAM, MMP2, NETO2, CTGF, and EDG2, were down-regulated by wild-type but not by mutant Nm23-H1 expression...

Research Grants3

  1. Susumu Tomita; Fiscal Year: 2014
    ..We have recently identified a novel transmembrane protein, NETO2 that interacts with the kainate receptor, using an unbiased proteomic screen...
  2. Single Channel Properties and Structure of Glutamate Receptors
    James R Howe; Fiscal Year: 2012
    ..the prior funding period, we demonstrated that the kainate subtype of iGluRs also have auxiliary subunits (NETO1, NETO2) that modulate receptor kinetics...
  3. Genomic analysis of RNA binding protein target specificity
    JEREMY ROBERT SANFORD; Fiscal Year: 2010
    ..2) Determine the genomic landscape of cis-acting RNA elements recognized by SR proteins. (3) Functionally validate SR protein cis-acting RNA elements. ..

Patents2

  1. Primers for synthesizing full length cDNA clones and their use
    Patent Number: EP1396543-A2; Date:2004-03-10
  2. Compositions and methods for the treatment of immune related diseases
    Patent Number: WO0140465-A2; Date:2001-06-07