nestin

Summary

Gene Symbol: nestin
Description: nestin
Alias: Nbla00170, nestin
Species: human

Top Publications

  1. ncbi Distribution of nestin immunoreactivity in the normal adult human forebrain
    Huaiyu Gu
    Department of Neurobiology and Anatomy, Sun Yat Sen University of Medical Sciences, 74 Zhongshan 2nd Road, Guangzhou 510089, PR China
    Brain Res 943:174-80. 2002
  2. pmc Novel nuclear export signal-interacting protein, NESI, critical for the assembly of hepatitis delta virus
    Yun Hsin Wang
    Institute of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, No 1, Jen Ai Road, First Section, Taipei 100, Taiwan
    J Virol 79:8113-20. 2005
  3. ncbi Feasibility study of Nestorone-ethinylestradiol vaginal contraceptive ring for emergency contraception
    Horatio B Croxatto
    Instituto Chileno de Medicina Reproductiva, Jose Ramon Gutierrez 295, Apt 3, Santiago, Chile
    Contraception 73:46-52. 2006
  4. ncbi Nighttime eating: a descriptive study
    Martina de Zwaan
    Department of Psychosomatic Medicine and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Int J Eat Disord 39:224-32. 2006
  5. pmc A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death
    Cecilia M Sahlgren
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finlandand
    EMBO J 25:4808-19. 2006
  6. ncbi Tissue-specific muscle, neural and liver stem/progenitor cells reside in the bone marrow, respond to an SDF-1 gradient and are mobilized into peripheral blood during stress and tissue injury
    Magda Kucia
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202 3270, USA
    Blood Cells Mol Dis 32:52-7. 2004
  7. doi Expression and distribution patterns of the stem cell marker, nestin, and the stem cell renewal factor, BMI-1, in normal human nasal mucosa and nasal polyps
    Tae Hoon Kim
    Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, Korea University, Seoul, South Korea
    Acta Otolaryngol 129:996-1001. 2009
  8. ncbi Analysis of VEGF, Flt-1, Flk-1, nestin and MMP-9 in relation to astrocytoma pathogenesis and progression
    A Hlobilkova
    Institute of pathology and Laboratory of Molecualr Pathology, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, Olomouc, CZ 775 15, Czech Republic
    Neoplasma 56:284-90. 2009
  9. doi Nestin-positive stem cells in neurofibromas from patients with neurofibromatosis type 1-tumorigenic or incidental?
    Marinya Pongpudpunth
    Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, MA 02118, USA
    Am J Dermatopathol 32:574-7. 2010
  10. pmc Isolation of mineralizing Nestin+ Nkx6.1+ vascular muscular cells from the adult human spinal cord
    Daria Mamaeva
    CNRS UPR 1142, Institute of Human Genetics, 141, rue de la Cardonille, 34396 Montpellier Cedex 05, France
    BMC Neurosci 12:99. 2011

Research Grants

  1. Lizabeth A Allison; Fiscal Year: 2015
  2. Development of Small Molecule Crm-1 Inhibitor for Pancreatic Cancer Therapy
    Ramzi M Mohammad; Fiscal Year: 2013
  3. Alberto J Espay; Fiscal Year: 2015
  4. REGULATION OF NUCLEAR PORE COMPLEX ASSEMBLY
    Susan R Wente; Fiscal Year: 2011
  5. Zijie Sun; Fiscal Year: 2015
  6. Carol Prives; Fiscal Year: 2016
  7. Role of Ubp-M and H2A deubiquitination in chromatin and cellular function
    Hengbin Wang; Fiscal Year: 2012
  8. REGINE SITRUK WARE; Fiscal Year: 2016
  9. Mechanism and regulation of LULL 1-directed NE enrichment of TorsinA
    ABIGAIL BUCHWALTER VANDERHEYDEN; Fiscal Year: 2011
  10. Investigation of influenza virulence mediated by the NS1A protein
    DIANA NOAH; Fiscal Year: 2007

Detail Information

Publications253 found, 100 shown here

  1. ncbi Distribution of nestin immunoreactivity in the normal adult human forebrain
    Huaiyu Gu
    Department of Neurobiology and Anatomy, Sun Yat Sen University of Medical Sciences, 74 Zhongshan 2nd Road, Guangzhou 510089, PR China
    Brain Res 943:174-80. 2002
    The distribution of nestin immunoreactivity was studied in the whole normal adult human forebrains using new anti-human nestin mouse monoclonal and rabbit polyclonal antiserum...
  2. pmc Novel nuclear export signal-interacting protein, NESI, critical for the assembly of hepatitis delta virus
    Yun Hsin Wang
    Institute of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, No 1, Jen Ai Road, First Section, Taipei 100, Taiwan
    J Virol 79:8113-20. 2005
    ..These data indicate a critical role of NESI in the assembly of HDV through interaction with HDAg-L...
  3. ncbi Feasibility study of Nestorone-ethinylestradiol vaginal contraceptive ring for emergency contraception
    Horatio B Croxatto
    Instituto Chileno de Medicina Reproductiva, Jose Ramon Gutierrez 295, Apt 3, Santiago, Chile
    Contraception 73:46-52. 2006
    ..Here, we report a Phase I clinical trial to determine the usefulness of this ring for emergency contraception. To that end, we tested the ability of this ring to interfere with ovulation when it is inserted during the follicular phase...
  4. ncbi Nighttime eating: a descriptive study
    Martina de Zwaan
    Department of Psychosomatic Medicine and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Int J Eat Disord 39:224-32. 2006
    ..Researchers have cogently argued for consideration of wide ranges including "subsyndromal" cases before reifying diagnostic constructs prematurely...
  5. pmc A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death
    Cecilia M Sahlgren
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finlandand
    EMBO J 25:4808-19. 2006
    The intermediate filament protein, nestin, has been implicated as an organizer of survival-determining signaling molecules...
  6. ncbi Tissue-specific muscle, neural and liver stem/progenitor cells reside in the bone marrow, respond to an SDF-1 gradient and are mobilized into peripheral blood during stress and tissue injury
    Magda Kucia
    Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202 3270, USA
    Blood Cells Mol Dis 32:52-7. 2004
    ..of this concept, we report here that mRNA of several early markers for muscle (Myf-5, Myo-D), neural (GFAP, nestin) and liver (CK19, fetoprotein) is detectable in circulating (adherent cell-depleted) peripheral blood mononuclear ..
  7. doi Expression and distribution patterns of the stem cell marker, nestin, and the stem cell renewal factor, BMI-1, in normal human nasal mucosa and nasal polyps
    Tae Hoon Kim
    Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, Korea University, Seoul, South Korea
    Acta Otolaryngol 129:996-1001. 2009
    These results suggest that nestin and BMI-1 are candidates for stem cell markers and renewal factors in human nasal mucosa, may contribute to tissue homeostasis and differentiation in the epithelium and submucosal glands of normal nasal ..
  8. ncbi Analysis of VEGF, Flt-1, Flk-1, nestin and MMP-9 in relation to astrocytoma pathogenesis and progression
    A Hlobilkova
    Institute of pathology and Laboratory of Molecualr Pathology, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, Olomouc, CZ 775 15, Czech Republic
    Neoplasma 56:284-90. 2009
    ..vascular endothelial growth factor (VEGF), VEGF receptors (Flk-1, and Flt-1), the intermediate filamental protein nestin which plays a role in central nervous system development, and MMP-9, which belongs the family of matrix ..
  9. doi Nestin-positive stem cells in neurofibromas from patients with neurofibromatosis type 1-tumorigenic or incidental?
    Marinya Pongpudpunth
    Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, MA 02118, USA
    Am J Dermatopathol 32:574-7. 2010
    ..Recently, we found discrete foci of melanin deposits but diffuse positivity with MART-1/MelanA in a neurofibroma from a patient with neurofibromatosis type 1 (NF1)...
  10. pmc Isolation of mineralizing Nestin+ Nkx6.1+ vascular muscular cells from the adult human spinal cord
    Daria Mamaeva
    CNRS UPR 1142, Institute of Human Genetics, 141, rue de la Cardonille, 34396 Montpellier Cedex 05, France
    BMC Neurosci 12:99. 2011
    ..We previously isolated Nestin+ Sox2+ neural multipotential cells from the adult human spinal cord using the neurosphere method (i.e...
  11. ncbi Multipotential nestin and Isl-1 positive mesenchymal stem cells isolated from human pancreatic islets
    Michael Eberhardt
    Division for Endocrinology, Diabetes and Clinical Nutrition, Department of Research, University Hospital Basel, Switzerland
    Biochem Biophys Res Commun 345:1167-76. 2006
    Mesenchymal cells in the developing pancreas express the neural stem cell marker nestin and the transcription factor islet-1 (Isl-1)...
  12. ncbi Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilaments
    J Dahlstrand
    Department of Molecular Genetics, Karolinska Institute, Stockholm, Sweden
    J Cell Sci 103:589-97. 1992
    ..gene expression accompany this transition out of the precursor state: transcription of the intermediate filament nestin is replaced by that of the neurofilaments...
  13. ncbi Identification of major cell classes in the developing mammalian nervous system
    S Hockfield
    J Neurosci 5:3310-28. 1985
    ..In addition, we report a marker for another cell class present in the developing nervous system, the endothelial cells that give rise to the CNS vasculature...
  14. pmc Heterogeneity of neural progenitor cells revealed by enhancers in the nestin gene
    P J Yaworsky
    Molecular Neuroscience Program, Samuel C Johnson Medical Research Center, Scottsdale, Arizona, 85259, USA
    Dev Biol 205:309-21. 1999
    ..each requiring the cooperation of at least two independent regulatory sites, within the second intron of the rat nestin gene...
  15. ncbi Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase
    C M Sahlgren
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, FIN 20521 Turku, Finland
    J Biol Chem 276:16456-63. 2001
    The intermediate filament protein nestin is expressed during early stages of development in the central nervous system and in muscle tissues...
  16. pmc Cdk5 regulates the organization of Nestin and its association with p35
    Cecilia M Sahlgren
    Department of Biology, Abo Akademi University, BioCity, Finland
    Mol Cell Biol 23:5090-106. 2003
    The intermediate filament protein nestin is characterized by its specific expression during the development of neuronal and myogenic tissues...
  17. ncbi Nestin is a potential mediator of malignancy in human neuroblastoma cells
    Sharon K Thomas
    Laboratory of Neurobiology, Department of Biological Sciences, Fordham University, 441 East Fordham Road, Bronx, NY 10458, USA
    J Biol Chem 279:27994-9. 2004
    ..Likewise, overexpression of the intermediate filament nestin, a neuroectodermal stem cell marker, is linked to increased aggressiveness in several nervous system tumors...
  18. ncbi Nestin expression--a property of multi-lineage progenitor cells?
    C Wiese
    In Vitro Differentiation Group, Institute of Plant Genetics and Crop Plant Research IPK Gatersleben, Corrensstrasse 3, 06466, Gatersleben, Germany
    Cell Mol Life Sci 61:2510-22. 2004
    ..In this review, we describe what is currently known about nestin, an intermediate filament first identified in neuroepithelial stem cells...
  19. ncbi Nestin expression by newly formed human blood vessels
    J Mokry
    Department of Histology and Embryology, Charles University in Prague, Medical Faculty in Hradec Kralove, Czech Republic
    Stem Cells Dev 13:658-64. 2004
    b>Nestin is a type VI intermediate filament protein originally described in neural stem cells. Here we report that immature endothelial cells generated in the course of angiogenesis express nestin...
  20. ncbi Nestin immunoreactivity of Purkinje cells in Creutzfeldt-Jakob disease
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    J Neurol Sci 246:131-7. 2006
    b>Nestin, an intermediate filament protein, is mainly expressed in neural progenitor/stem cells in the central nervous system. Recently, we reported that nestin is expressed in Purkinje cells in patients with Creutzfeldt-Jakob disease (CJD)...
  21. ncbi Identification of neovasculature using nestin in colorectal cancer
    Nobuhisa Teranishi
    Department of Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Int J Oncol 30:593-603. 2007
    ..However, this marker detects not only newly formed, but also pre-existing large blood vessels. Nestin, a class VI intermediate filament protein, has recently received attention as a marker for detecting newly formed ..
  22. pmc Roles for the stem cell associated intermediate filament Nestin in prostate cancer migration and metastasis
    Wolfram Kleeberger
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Res 67:9199-206. 2007
    The intermediate filament protein Nestin identifies stem/progenitor cells in adult tissues, but the function of Nestin is poorly understood. We investigated Nestin expression and function in common lethal cancers...
  23. pmc Nestin expression correlates with nerve and retroperitoneal tissue invasion in pancreatic cancer
    Masao Kawamoto
    Surgery for Organ and Biological Regulation Department of Surgery I, Graduate School of Medicine, Nippon Medical School, Tokyo 113 8603, Japan
    Hum Pathol 40:189-98. 2009
    b>Nestin was first described as an intermediate filament protein expressed in neuroepithelial stem cells. Nestin expression has also been reported in brain tumors, schwannomas, gastrointestinal stromal tumors, and melanomas...
  24. doi Expression of nestin in lymph node metastasis and lymphangiogenesis in non-small cell lung cancer patients
    Zhenguang Chen
    Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong 510080, P R China
    Hum Pathol 41:737-44. 2010
    Stem cell marker nestin has been reported to be activated in various neoplasms, and its expression is correlated with poor prognosis. However, nestin expression in non-small cell lung cancer still remains unclear...
  25. doi Neuroepithelial stem cell marker nestin regulates the migration, invasion and growth of human gliomas
    Toshiyuki Ishiwata
    Department of Pathology, Nippon Medical School, Bunkyo ku, Tokyo 113 8602, Japan
    Oncol Rep 26:91-9. 2011
    b>Nestin, a class VI intermediate filament protein, was originally described as a neuronal stem cell marker during central nervous system development...
  26. ncbi Nestin and caveolin-1 in the diagnosis of GISTs
    Simona Enache
    Victor Babes National Institute, Bucharest, Romania
    Rom J Morphol Embryol 53:41-6. 2012
    ..Recently, it was reported that nestin and caveolin-1 are also expressed in some human sarcomas, GISTs included...
  27. doi Stem cell marker nestin is critical for TGF-β1-mediated tumor progression in pancreatic cancer
    Huei Ting Su
    Institute of Biomedical Sciences, National Sun Yat Sen University, Kaohsiung, Taiwan 80424
    Mol Cancer Res 11:768-79. 2013
    The stem cell marker nestin is an intermediate filament protein that plays an important role in cell integrity, migration, and differentiation...
  28. ncbi Intermediate filament nestin expressions in human cord blood monocytes (HCMNCs)
    Y Ha
    Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea
    Acta Neurochir (Wien) 145:483-7. 2003
    b>Nestin is an intermediate protein and a well-known specific neural stem cell antigen. Some bone marrow stem cells can generate not only blood cells but also neurons and glial cells under specific culture conditions...
  29. ncbi Expression of nestin in Purkinje cells in patients with Creutzfeldt-Jakob disease
    Yuji Mizuno
    Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Neurosci Lett 352:109-12. 2003
    b>Nestin is one of the intermediate filament proteins and mainly expressed during the development of the central nervous system...
  30. ncbi Expression of nestin in rat and human glomerular podocytes
    M Ishizaki
    Department of Pathology I, Nippon Medical School, Tokyo, Japan
    J Submicrosc Cytol Pathol 38:193-200. 2006
    b>Nestin is a neuroepithelial precursor cell marker expressed in a variety of human cell types during development. However, no information exists on the expression of nestin in mature glomeruli as well as during the glomerular development...
  31. doi Expression of nestin mRNA is a differentiation marker in thyroid tumors
    Hiroya Yamada
    Department of Laboratory Medicine, Osaka University Medical School, 2 2 D2, Yamadaoka, Suita, Osaka 565 0871, Japan
    Cancer Lett 280:61-4. 2009
    b>Nestin is a maker that identifies stem cells in some adult tissues, and its expression is believed to relate to malignancy in cancer cells...
  32. ncbi The stem cell marker nestin predicts poor prognosis in human melanoma
    Franca Piras
    Department of Cytomorphology, University of Cagliari, Cittadella Universitaria, Monserrato CA, Italy
    Oncol Rep 23:17-24. 2010
    ..b>Nestin and CD133 have been described as markers of melanocytic stem cells...
  33. ncbi Transplantation of clonal neural precursor cells derived from adult human brain establishes functional peripheral myelin in the rat spinal cord
    Y Akiyama
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, 060 8543, Japan
    Exp Neurol 167:27-39. 2001
    ..Sections of removed brain indicated that nestin-positive cells were found predominantly in the subventricular zone around the anterior horns of the lateral ..
  34. ncbi Nestin promoter/enhancer directs transgene expression to precursors of adult generated periglomerular neurons
    Robert D Beech
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor, New Haven, CT 06508, USA
    J Comp Neurol 475:128-41. 2004
    ..In the present study, we used the nestin promoter and enhancer to direct expression of the tetracycline transactivator (tTA)...
  35. ncbi Angiogenic endothelium-specific nestin expression is enhanced by the first intron of the nestin gene
    Masanori Aihara
    Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
    Lab Invest 84:1581-92. 2004
    b>Nestin is a member of intermediate filaments abundantly expressed in neural stem cells and glioblastomas. The nestin gene has four exons and three introns, and neural cell-specific expression is regulated by the second intron...
  36. ncbi Granular cell tumours of the gastrointestinal tract: expression of nestin and clinicopathological evaluation of 11 patients
    J R Parfitt
    Department of Pathology, London Health Sciences Centre, University of Western Ontario, London, Canada
    Histopathology 48:424-30. 2006
    ..b>Nestin is a recently identified intermediate filament protein that is expressed in neuroectodermal stem cells and ..
  37. pmc Yeast heat shock mRNAs are exported through a distinct pathway defined by Rip1p
    C A Saavedra
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Genes Dev 11:2845-56. 1997
    ....
  38. pmc Structural heterogeneity of the Fe(2+)-N epsilon (HisF8) bond in various hemoglobin and myoglobin derivatives probed by the Raman-active iron histidine stretching mode
    H Gilch
    Institute of Experimental Physics, University of Bremen, Germany
    Biophys J 65:1470-85. 1993
    ..Quaternary and tertiary transitions of the protein alter the population of these substates thus giving rise to a redistribution of the VFe-HiS sublines which shifts the corresponding peak frequency to higher values...
  39. ncbi The exclusion of non-English-speaking persons from research
    S M Frayne
    Section of General Internal Medicine, Boston University School of Medicine, MA, USA
    J Gen Intern Med 11:39-43. 1996
    ....
  40. ncbi Nocturnal eating: prevalence and features in 120 insomniac referrals
    R Manni
    Neurological Institute C. Mondino, University of Pavia, Italy
    Sleep 20:734-8. 1997
    ..g. associated with sleepwalking, restless legs syndrome, obstructive sleep apnea, etc.) and with eating disorders such as daytime binge eating...
  41. ncbi Antagonistic effects of NES and NLS motifs determine S. cerevisiae Rna1p subcellular distribution
    W Feng
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Cell Sci 112:339-47. 1999
    ..The data support the hypothesis that Rna1p exists on both sides of the nuclear membrane, perhaps regulating the Ran-GTP/Ran-GDP gradient, participating in a complete RanGTPase nuclear cycle or serving a novel function...
  42. ncbi Neurological soft signs in schizophrenia: assessment and correlates
    F Mohr
    Hospital Haar, Germany
    Eur Arch Psychiatry Clin Neurosci 246:240-8. 1996
    ..This close association of psychomotor and cognitive dysfunctions may be seen as related to the frequently discussed dysfunctions of the prefrontal cortex or the neurointegrative deficit postulated by Meehl...
  43. ncbi Body water handling in response to hypertonic-saline induced diuresis in fasting northern elephant seal pups (Mirounga angustirostris)
    Rudy M Ortiz
    Department of Biology, University of California, CA 95064, Santa Cruz, USA
    Comp Biochem Physiol A Mol Integr Physiol 134:423-8. 2003
    ..This water recycling mechanism may allow pups to avoid negative perturbations in body water as they initiate feeding in a marine environment following the fast...
  44. ncbi Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta
    B R Henderson
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, England
    J Mol Biol 274:693-707. 1997
    ..The series of interactions we describe provide a novel pathway for the import of Rev across the nuclear pore complex, and a mechanism for its release into the nucleoplasm...
  45. pmc Presence of a functional but dispensable nuclear export signal in the HTLV-2 Tax protein
    Sébastien A Chevalier
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, Paris, France
    Retrovirology 2:70. 2005
    ..We have recently demonstrated that Tax1 and Tax2 display different subcellular localization and that residues 90-100 are critical for this process. We investigate in the present report, whether Tax2 also possesses a functional NES...
  46. pmc A nuclear export signal in Kap95p is required for both recycling the import factor and interaction with the nucleoporin GLFG repeat regions of Nup116p and Nup100p
    M K Iovine
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 137:797-811. 1997
    ..This finding highlights an important role for a subfamily of GLFG nucleoporins in nuclear export processes...
  47. ncbi The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export
    M Neville
    Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02254, USA
    Curr Biol 7:767-75. 1997
    ..Crm1p has recently been shown to contribute to nuclear export in vertebrate systems. Here, we have studied this mechanism of nuclear to cytoplasmic transport...
  48. ncbi Contraceptive vaginal rings releasing Nestorone and ethinylestradiol: a 1-year dose-finding trial
    Irving Sivin
    Center for Biomedical Research, Population Council, New York, NY 10021, USA
    Contraception 71:122-9. 2005
    ..Clinical performance and adverse event profiles indicate that each of these 1-year NES/EE rings, used on a 21-day-in and 7-day-out regimen, provided women effective, acceptable and safe long-acting contraception under their own control...
  49. ncbi Serum Nestorone and ethinyl estradiol levels, and ovulation inhibition in women using three different dosage combinations of a Nestorone progestogen-ethinyl estradiol contraceptive vaginal ring on a bleeding-signaled regimen
    Ian S Fraser
    Department of Obstetrics and Gynaecology, University of Sydney, Sydney NSW 2006, Australia
    Contraception 72:40-5. 2005
    ....
  50. ncbi Clinical performance and menstrual bleeding patterns with three dosage combinations of a Nestorone progestogen/ethinyl estradiol contraceptive vaginal ring used on a bleeding-signaled regimen
    Edith Weisberg
    Sydney Center for Reproductive Health Research, Research Division of FPA Health, NSW 2131, Australia
    Contraception 72:46-52. 2005
    ..Ring removal times were signaled by menstrual events. Bleeding patterns, adverse events, patterns of use and continuation rates were the principal parameters evaluated...
  51. ncbi Opportunity for change in the future roles for the health library and information professional: meeting the challenges in NHS Scotland
    Gerry Maclean
    Knowledge Services Group, NHS Education for Scotland, 1st Floor, Clifton House, Clifton Place, Glasgow G3 7LD, UK
    Health Info Libr J 23:32-8. 2006
    ..The Knowledge Services Group also supports the national development of library services to NHS Scotland...
  52. ncbi Longitudinal study on potential neurotoxic effects of aluminium: I. Assessment of exposure and neurobehavioural performance of Al welders in the train and truck construction industry over 4 years
    E Kiesswetter
    Institute for Occupational Physiology, University of Dortmund, Ardeystr 67, 44139 Dortmund, Germany
    Int Arch Occup Environ Health 81:41-67. 2007
    ....
  53. ncbi The safety of intravenous diuretics alone versus diuretics plus parenteral vasoactive therapies in hospitalized patients with acutely decompensated heart failure: a propensity score and instrumental variable analysis using the Acutely Decompensated Heart
    Maria Rosa Costanzo
    Midwest Heart Foundation, Lombard, IL, USA
    Am Heart J 154:267-77. 2007
    ..Significant concerns have been expressed regarding risks and benefits of individual therapies, especially nesiritide (NES), but few studies have compared the relative safety of varied intravenous therapies on clinical outcomes...
  54. doi Relative progestational and androgenic activity of four progestins used for male hormonal contraception assessed in vitro in relation to their ability to suppress LH secretion in the castrate male rat
    Barbara J Attardi
    BIOQUAL, Inc Division of Reproductive Endocrinology and Toxicology, 9600 Medical Center Dr, Rockville, MD 20850, USA
    Mol Cell Endocrinol 328:16-21. 2010
    ..2mg/kg/day; and NES and CPA showed no or minimal LH suppression at doses up to 3.2mg/kg/day. We concluded, therefore, that suppression of LH is correlated with androgenic, rather than progestational, potency of the synthetic progestins...
  55. ncbi New progestagens for contraceptive use
    Regine Sitruk-Ware
    Rockefeller University and Population Council, New York, NY, USA
    Hum Reprod Update 12:169-78. 2006
    ..Given their pharmacological properties, it is likely that the new progestins may have neutral effects on metabolic or vascular risks. However, this hypothesis must be confirmed in large clinical trials...
  56. ncbi Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors
    A Kiss
    Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Avenue, Saint Louis, MO 63108, USA
    Virology 314:591-600. 2003
    ..These results suggest a physiological role for hNup98 in modulating Rev-dependent RNA export during HIV infection...
  57. ncbi The value of provocation methods in patients suspected of having non-epileptic seizures
    N Dericioglu
    Department of Neurology, Hacettepe University Hospital, Ankara, Turkey
    Seizure 8:152-6. 1999
    ..We claim that not all patients suspected of having NES need long-term video-EEG monitoring and almost half (54.2%) of the cases can be eliminated by seizure induction with some provocative techniques...
  58. ncbi Night eating syndrome and nocturnal snacking: association with obesity, binge eating and psychological distress
    S L Colles
    Centre for Obesity Research and Education, The Alfred Hospital, Monash University, Melbourne, Victoria, Australia
    Int J Obes (Lond) 31:1722-30. 2007
    ..This study aimed to investigate the clinical significance of NES and nocturnal snacking by exploring the relationship between NES and (1) obesity, (2) binge eating disorder (BED) and (3) psychological distress...
  59. pmc Drosophila lysophospholipid acyltransferases are specifically required for germ cell development
    Josefa Steinhauer
    Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Mol Biol Cell 20:5224-35. 2009
    ..Our findings suggest that lysophospholipid acyltransferase activity is essential for germline development and could provide a mechanistic explanation for the etiology of the human MBOAT1 mutation...
  60. ncbi Night eating syndrome is associated with depression, low self-esteem, reduced daytime hunger, and less weight loss in obese outpatients
    M E Gluck
    New York Obesity Research Center and Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
    Obes Res 9:264-7. 2001
    ..The objective of this study was to assess the relationship between the night eating syndrome (NES), measures of depression and self-esteem, test meal intake, and weight loss in obese participants...
  61. doi A comparison of personality disorder characteristics of patients with nonepileptic psychogenic pseudoseizures with those of patients with epilepsy
    Cynthia L Harden
    Comprehensive Epilepsy Center, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Epilepsy Behav 14:481-3. 2009
    ....
  62. ncbi Hospital CEOs, CFOs, and nurse executives: opportunities for a new alliance
    R B Dwore
    University of Utah, USA
    J Healthc Manag 43:136-51; discussion 152-4. 1998
    ..Together, CEOs, CFOs, and NEs can successfully take hospitals into the future by leading them in ongoing learning and change...
  63. pmc Nuclear import of Upf3p is mediated by importin-alpha/-beta and export to the cytoplasm is required for a functional nonsense-mediated mRNA decay pathway in yeast
    Renee L Shirley
    Laboratories of Genetics and Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 161:1465-82. 2002
    ..To explain these results, we suggest that the mutations in NES-A that impair nuclear export cause additional defects in the function of Upf3p that are not rectified by restoration of export alone...
  64. ncbi Carboxyl-terminal basic amino acids in the X domain are essential for the nuclear import of phospholipase C delta1
    Masashi Okada
    Department of Life Science, Faculty of Science, Himeji Institute of Technology, Harima Science Garden City, Hyogo 678 1297, Japan
    Genes Cells 7:985-96. 2002
    ..Since nucleocytoplasmic shuttling of a molecule is generally regulated by a balance between its NES and the nuclear localization signal (NLS), we examined whether PLCdelta1 contains an NLS sequence...
  65. pmc Binge eating disorder and night eating syndrome in adults with type 2 diabetes
    Kelly C Allison
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market Street, Suite 3021, Philadelphia, PA 19104 3309, USA
    Obesity (Silver Spring) 15:1287-93. 2007
    ..To determine the prevalence of binge eating disorder (BED) and night eating syndrome (NES) among applicants to the Look AHEAD (Action for Health in Diabetes) study...
  66. pmc Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cells
    Maria Lombardi
    Dipartimento di Patologia Generale, Il Università di Napoli, 80138 Naples, Italy
    J Cell Biol 182:327-40. 2008
    ..In conclusion, estradiol-induced AKT-dependent phosphorylation of FKHR drives its association with ERalpha, thereby triggering complex export from the nucleus necessary for initiation of DNA synthesis and S phase entry...
  67. ncbi The peer review pilot project: a potential system to support GP appraisal in NHS Scotland?
    Jill Murie
    NHS Education for Scotland, Glasgow, UK
    Educ Prim Care 20:34-40. 2009
    ..A comparative review of different systems in other countries suggests further research is necessary to provide greater evidence of feasibility, acceptability and educational benefit of such a system in the UK...
  68. doi Mechanisms of malarial anaemia: potential involvement of the Plasmodium falciparum low molecular weight rhoptry-associated proteins
    Nancy W Awah
    Wenner Gren Institute, Department of Immunology, Svante Arrhenius väg 20C, Stockholm University, SE 10 691 Stockholm, Sweden
    Acta Trop 112:295-302. 2009
    ..These observations could therefore have implications in the design, development and deployment of future therapeutic interventions against malaria...
  69. ncbi Effect of differently induced plasma norepinephrine increments on norepinephrine sulfate formation
    Gunther Strobel
    Dept of Sports Medicine, Free University of Berlin, Clayallee 225C, 14195 Berlin, Germany
    Life Sci 71:55-65. 2002
    ..Secondly, plasma NE may be a useful additional marker for NES release...
  70. ncbi Immunoglobulin responses of northern elephant and Pacific harbor seals naturally infected with Otostrongylus circumlitus
    Jocelyn G Elson-Riggins
    Department of Biology, University of California, Riverside, California 92521, USA
    J Wildl Dis 40:466-75. 2004
    ..The banding patterns suggest that O. circumlitus nematodes die and disintegrate in PHS and NES and that NES of 1 yr and older and most PHS respond differently to the ES glands than 2- to 9-mo-old NES...
  71. ncbi Activation of transcription factor AP-1 and mitogen-activated protein kinases in aniline-induced splenic toxicity
    M Firoze Khan
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Toxicol Appl Pharmacol 210:86-93. 2006
    ..The observed sequence of events subsequent to aniline exposure could regulate genes that lead to fibrogenic and/or tumorigenic response in the spleen...
  72. ncbi Nucleocytoplasmic shuttling of phospholipase C-delta1: a link to Ca2+
    Hitoshi Yagisawa
    Graduate School of Life Science, University of Hyogo, Harima Science Garden City, Hyogo 678 1297, Japan
    J Cell Biochem 97:233-43. 2006
    ..The consequence of the nuclear accumulation of PLC is also discussed...
  73. ncbi Factor structure of the Neurological Evaluation Scale in a predominantly African American sample of patients with schizophrenia, unaffected relatives, and non-psychiatric controls
    Michael T Compton
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 49 Jesse Hill Jr Drive, S E, Atlanta, GA 30303, USA
    Schizophr Res 84:365-77. 2006
    ..This study aimed to identify latent factors of the most widely used scale to measure neurological soft signs, the Neurological Evaluation Scale (NES), in a sample of schizophrenia patients, their relatives, and non-psychiatric controls...
  74. ncbi MMPI-2 profiles of persons with multiple chemical sensitivity
    Laurence M Binder
    Oregon Health and Sciences University, Beaverton, OR, USA
    Clin Neuropsychol 20:848-57. 2006
    ..We conclude that MMPI-2 data, obtained from people seeking financial compensation, indicate that there is a strong psychological component to MCS symptoms...
  75. ncbi Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice
    M V Schmidt
    Max Planck Institute of Psychiatry, RG Molecular Stress Physiology, Kraepelinstr 2 10, 80804 Munich, Germany
    Eur J Neurosci 24:2291-8. 2006
    ....
  76. pmc Nuclear export of human papillomavirus type 31 E1 is regulated by Cdk2 phosphorylation and required for viral genome maintenance
    Amelie Fradet-Turcotte
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
    J Virol 84:11747-60. 2010
    ..On the basis of these results, we propose that nuclear export of E1 is required, at least in part, to limit accumulation of this viral helicase in the nucleus in order to prevent its detrimental effect on cellular proliferation...
  77. pmc Nucleocytoplasmic distribution and dynamics of the autophagosome marker EGFP-LC3
    Kimberly R Drake
    Department of Molecular Physiology and Biophysics, Vanderbilt School of Medicine, Nashville, Tennessee, United States of America
    PLoS ONE 5:e9806. 2010
    ..Instead, incorporation of soluble EGFP-LC3 into large macromolecular complexes within both the cytoplasm and nucleus may prevent its rapid equilibrium between the two compartments...
  78. pmc A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus
    F Stutz
    Department of Biology, Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02254, USA
    Mol Cell Biol 16:7144-50. 1996
    ..The results suggest that Rev and cellular mediators of RNA export can interact with multiple components of the nuclear pore complex during transport, analogous to the proposed mode of action of the nuclear protein import receptor...
  79. pmc Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1
    H P Bogerd
    Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Virol 72:8627-35. 1998
    ..In addition, these data identify a novel and highly potent inhibitor of leucine-rich NES-dependent nuclear export...
  80. ncbi Non-epileptic seizures of the elderly
    Christoph Kellinghaus
    Department of Neurology, The Cleveland Clinic Foundation, Ohio, USA
    J Neurol 251:704-9. 2004
    ..To characterize non-epileptic seizures (NES) in the elderly and compare their features with NES of a younger control group...
  81. ncbi [Changes of electroencephalographic background patterns and serum neuron specific enolase levels in neonates with hypoxic-ischemic encephalopathy]
    Hong Qing Dai
    Department of Pediatrics, People s Hospital of Wugang, Wugang, Hunan 422400, China
    Zhongguo Dang Dai Er Ke Za Zhi 11:173-6. 2009
    ....
  82. ncbi Nuclear export of proteins in plants: AtXPO1 is the export receptor for leucine-rich nuclear export signals in Arabidopsis thaliana
    D Haasen
    University of Freiburg, Institute for Biology II, Cell Biology, Schänzlestr 1, D 79104 Freiburg, Germany
    Plant J 20:695-705. 1999
    ..In BY-2 protoplasts the NES of AtRanBP1a is functionally indistinguishable from the Rev NES. Our results demonstrate that the machinery for the nuclear export of proteins is functionally conserved in plants...
  83. ncbi Multiple strategies of schistosomes to meet their requirements in the intermediate snail host
    M de Jong-Brink
    Research Institute Neurosciences, Vrije Universiteit, Faculty of Biology, Amsterdam, The Netherlands
    Parasitology 123:S129-41. 2001
    ..The physiological changes in the snail host are obviously of vital importance for the parasites, since they make use of different strategies to bring them about...
  84. doi Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration
    Leen Hulshagen
    Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Belgium
    J Neurosci 28:4015-27. 2008
    ..These anomalies of myelinated axons were already present in juvenile mice but aggravated in adulthood. Together, loss of CNS peroxisomal metabolism both affects myelin sheaths and axonal integrity possibly via independent pathways...
  85. ncbi Ovarian function during use of vaginal rings delivering three different doses of Nestorone
    V Brache
    PROFAMILIA, Santo Domingo, Dominican Republic
    Contraception 63:257-61. 2001
    ..We conclude that the 50 and 75 microg/day NES rings provide adequate ovulation inhibition without hypoestrogenism, while the 100 microg/day ring may deliver an unnecessarily high dose...
  86. ncbi Chronic ischemic monomelic neuropathy from critical limb ischemia
    D H Weinberg
    Department of Neurology, Tufts University School of Medicine, St Elizabeth s Medical Center, Boston, MA 02135, USA
    Neurology 57:1008-12. 2001
    ..To describe the peripheral neuropathy resulting from chronic and critical arterial leg ischemia...
  87. ncbi A nuclear export signal prevents Saccharomyces cerevisiae Hsp70 Ssb1p from stimulating nuclear localization signal-directed nuclear transport
    N Shulga
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    J Biol Chem 274:16501-7. 1999
    ..We conclude that the differential function of Ssa1p and Ssb1p in nuclear transport is due to the NES-directed export of the Ssb1p and not to functional differences in their ATPase or peptide binding domains...
  88. pmc The NES-Crm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiae
    M Neville
    Howard Hughes Medical Institute, Department of Biology, MS008 Brandeis University, Waltham, MA 02454, USA
    EMBO J 18:3746-56. 1999
    ..cerevisiae. We conclude that Crm1p structure and function is conserved from S.cerevisiae to man...
  89. ncbi Nuclear envelope associated protein that binds telomeric DNAs
    O I Podgornaya
    Institute of Cytology RAS, St Petersburg, Russia
    Mol Reprod Dev 57:16-25. 2000
    ..This is the first clear evidence of a protein, which could be responsible for the attachment of telomeres to the nuclear membrane...
  90. ncbi A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation
    Y Zhang
    Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, and Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, NC 27599 7295, USA
    Science 292:1910-5. 2001
    ..Serine-15-phosphorylated p53 induced by ultraviolet irradiation was not exported. Thus, DNA damage-induced phosphorylation may achieve optimal p53 activation by inhibiting both MDM2 binding to, and the nuclear export of, p53...
  91. pmc A masked NES in INI1/hSNF5 mediates hCRM1-dependent nuclear export: implications for tumorigenesis
    Errol Craig
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
    EMBO J 21:31-42. 2002
    ..These observations demonstrate that INI1 has a masked NES that mediates regulated hCRM1/exportin1-dependent nuclear export and we propose that mutations that cause deregulated nuclear export of the protein could lead to tumorigenesis...
  92. ncbi Satisfactory completion of dental vocational training in Scotland: a system of assessment
    L Prescott-Clements
    NHS Education for Scotland, The Lister, 11 Hill Square, Edinburgh EH8 9DR
    Br Dent J . 2003
    ..During the life of this project the argument for introducing assessment of DVT and General Professional Training (GPT) has become ever stronger...
  93. ncbi Neurological soft signs in adolescents with first episode psychosis
    Arantzazu Zabala
    Unidad de Adolescentes, Departamento de Psiquiatria, Hospital General Universitario Gregorio Maranon, C Ibiza 43, 28009 Madrid, Spain
    Eur Psychiatry 21:283-7. 2006
    ..We did not find a clear pattern of NSS that distinguished schizophrenia from other psychoses...
  94. ncbi Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury
    Seiji Okada
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nat Med 12:829-34. 2006
    ..These results suggest that Stat3 is a key regulator of reactive astrocytes in the healing process after SCI, providing a potential target for intervention in the treatment of CNS injury...
  95. ncbi A paradigm for facilitating pharmacotherapy at a distance: sertraline treatment of the night eating syndrome
    Albert J Stunkard
    Department of Psychiatry Weight and Eating Disorders Program, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Clin Psychiatry 67:1568-72. 2006
    ..To test a novel method of facilitating pharmacotherapy at a distance and assess the effectiveness of sertraline for the treatment of night eating syndrome (NES)...
  96. doi Differential regulation of CuZnSOD expression in rat brain by acute and/or chronic stress
    DRAGANA FILIPOVIC
    Laboratory of Molecular Biology and Endocrinology, Institute of Nuclear Sciences Vinca, P O Box 522 090, 11000, Belgrade, Serbia
    Cell Mol Neurobiol 29:673-81. 2009
    ..The results suggest that different stress models exert a different degree of influence on mRNA and protein level of CuZnSOD in both brain structures as well as serum corticosterone...
  97. doi [Immunohistochemical demonstration of mutant nucleophosmin in acute myeloid leukemia: biological and clinical features related to NPMc expression]
    Judit Bedekovics
    Debreceni Egyetem, Orvos és Egészségtudományi Centrum, Patológiai Intézet, Debrecen
    Orv Hetil 150:1031-5. 2009
    ..These results are in agreement with previous studies. In conclusion, immunohistochemistry is well applicable for the identification of NPM mutated AML in the daily hematopathology practice...
  98. doi Nestin expression in glial and neuronal progenitors of the developing human spinal ganglia
    Katarina Vukojevic
    Department of Anatomy, Histology and Embryology, School of Medicine, University of Split, 21000 Split, Croatia
    Gene Expr Patterns 10:144-51. 2010
    Expression of the neural crest marker nestin was studied in glial and neuronal progenitors of developing human spinal ganglia using immunohistochemistry in 10 conceptuses, 5-10 weeks old...
  99. doi Nocturnal eating predicts tooth loss among adults: results from the Danish MONICA study
    Jennifer D Lundgren
    Department of Psychology, University of Missouri Kansas City, 4825 Troost Avenue, Ste 124, Kansas City, MO 64110, United States
    Eat Behav 11:170-4. 2010
    ..0001). In sum, nocturnal eating contributes to tooth loss. Treatment providers should encourage good oral health care practices to reduce the risk of tooth loss associated with nocturnal eating...
  100. doi The efficiency of electrical stimulation to counteract the negative effects of β-agonists on meat tenderness of feedlot cattle
    M Hope-Jones
    Department of Animal and Wildlife Sciences, University of Pretoria, Pretoria, 0002, South Africa
    Meat Sci 86:699-705. 2010
    ..ES can therefore be implemented to improve meat tenderness in zilpaterol supplemented steers, although steers without zilpaterol will still have an advantage in final tenderness...
  101. doi Subcellular sites of the signal transduction and degradation of phytochrome A
    Gabriela Toledo-Ortiz
    Department of Botany, Graduate School of Science, Kyoto University, Kyoto, 606 8502 Japan
    Plant Cell Physiol 51:1648-60. 2010
    ..In addition, a detailed time course analysis of phyA-GFP and phyA-GFP-NLS responses revealed that they were almost indistinguishable, raising the question of the physiological relevance of phyA cytoplasmic retention in darkness...

Research Grants57

  1. Lizabeth A Allison; Fiscal Year: 2015
    ....
  2. Development of Small Molecule Crm-1 Inhibitor for Pancreatic Cancer Therapy
    Ramzi M Mohammad; Fiscal Year: 2013
    ..Our newly developed KPT-SINE's are highly specific, orally active drugs with excellent pharmacokinetic parameters and hold promise against deadly pancreatic cancer. ..
  3. Alberto J Espay; Fiscal Year: 2015
    ..Ultimately, the candidate will be equipped to become a successful independent investigator, advancing the knowledge and management of a largely neglected but promising group of disorders. ..
  4. REGULATION OF NUCLEAR PORE COMPLEX ASSEMBLY
    Susan R Wente; Fiscal Year: 2011
    ..Knowledge of how nuclear pore complexes are assembled and function will be important for finding therapeutic strategies to regulate nuclear transport in disease states and moderate viral proliferation/pathogenesis. ..
  5. Zijie Sun; Fiscal Year: 2015
    ..Insights into new diagnostic markers, therapeutic targets and approaches for prostate cancer and other tumors are expected. ..
  6. Carol Prives; Fiscal Year: 2016
    ..We will elucidate the mechanism by which MdmX increases Mdm2 and Wip1 expression, via increasing p53 binding to their promoters. Finally we will validate our findings in cells from MdmX null mice. ..
  7. Role of Ubp-M and H2A deubiquitination in chromatin and cellular function
    Hengbin Wang; Fiscal Year: 2012
    ..However, due to the amount of work in this application and the uncertain outcome of these experiments, we did not list these experiments as a Specific Aim. ..
  8. REGINE SITRUK WARE; Fiscal Year: 2016
    ..SA2: Unravel molecular mechanism(s) by which adjudin-IMB disrupts adhesion protein complexes at the apical ectoplasmic specialization. SA3: Complete toxicity program to prepare for clinical use in men. ..
  9. Mechanism and regulation of LULL 1-directed NE enrichment of TorsinA
    ABIGAIL BUCHWALTER VANDERHEYDEN; Fiscal Year: 2011
    ..In accordance with the mission of the NIH, the main goal of these Aims is to understand the cellular function of a disease-associated protein in order to gain an understanding of the molecular mechanism of a disease. ..
  10. Investigation of influenza virulence mediated by the NS1A protein
    DIANA NOAH; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  11. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    Alice Sheridan; Fiscal Year: 2005
    ..A better understanding of these events may allow us to develop therapies to better treat these incapacitating and costly diseases. ..
  12. VALIDITY OF COMPUTERIZED TESTS IN OCCUPATIONAL SETTINGS
    Roberta White; Fiscal Year: 1993
    ....
  13. Akt Intracellular Localization in Thyroid Cancer
    Matthew Ringel; Fiscal Year: 2009
    ..abstract_text> ..
  14. Regulation of the Spindle Checkpoint Protein Bub1p
    YANIRA GONZALEZ; Fiscal Year: 2009
    ..Taken together, these studies will provide insight in how the intracellular localization and function of Bublp is regulated. ..
  15. Nematode UNC-98 functions in focal adhensions and nuclei
    GUY BENIAN; Fiscal Year: 2009
    ..abstract_text> ..
  16. Heparan sulfate in neural development
    Yu Yamaguchi; Fiscal Year: 2007
    ..We will perform histological, cell biological, and physiological analyses to determine the physiological role of HS in CNS synapses. ..
  17. CIITA and MHC II Transcription
    BORIS PETERLIN; Fiscal Year: 2007
    ..Collectively, these studies will reveal the normal physiology of CIITA, why it oligomerizes and shuttles, and create new tools to manipulate the immune response in health and disease. ..
  18. Regulation of Homeodomain Nuclear Translocation
    Christopher Bonin; Fiscal Year: 2002
    ..We also believe that the characterization of factors required for regulating subcellular localization of Exd may lead to the identification of other proteins that rely on this process for their regulation. ..
  19. Mechanism of Constitutive NF-kappa B Activity
    Shigeki Miyamoto; Fiscal Year: 2007
    ..They may also reveal N-NES-mediated nuclear export of IkappaBalpha as a rational therapeutic target to generally disrupt constitutive NF-kappaB activation to induce cell death or chemo/radiosensitization in human cancer. ..
  20. Intracellular Localization of HIV-1 RNAs by Rev&Matrix
    Michael Green; Fiscal Year: 2005
    ..Finally, our results suggest a novel method for inhibiting the activity of any mRNA. This "mRNA nuclear entrapment" strategy will be developed and tested using HIV-1 replication as a model system. ..
  21. STABILITY OF INDIVIDUAL DIFFERENCES
    DUANE ALWIN; Fiscal Year: 2000
    ..Estimates of these components will be obtained using structural equation analysis of latent growth curves employing a variety of different model specifications. ..
  22. AR intracellular trafficking in prostate cancer
    Zhou Wang; Fiscal Year: 2009
    ..5. Characterize the role of HSP90 in NES-AR action. We will test if HSP90 directly interacts with NES-AR and/or influences the nuclear export machinery. ..
  23. The Prevalence of two eating disorders
    Albert Stunkard; Fiscal Year: 2003
    ..This information will be gathered upon subjects' entry into the Look AHEAD trial and again at six months and one year into treatment to assess the stability of the diagnosis. ..
  24. THE NIGHT EATING SYNDROME
    Albert Stunkard; Fiscal Year: 2005
    ..She will develop a manual for the treatment of the NES in consultation with the Beck Institute and will test its efficacy. ..
  25. CLINICAL AND EXPERIMENTAL STUDY OF HUMAN OBESITY
    Albert Stunkard; Fiscal Year: 2002
    ..Our ultimate objective is to identify behaviors that contribute to adiposity and that might be modified in programs of prevention and treatment. ..
  26. COMMON FEATURES OF REV LIKE VIRAL REGULATORY PROTIENS
    Thomas Hope; Fiscal Year: 2001
    ..This basic knowledge may lay the groundwork for novel therapeutic approaches targeting Rev function. ..
  27. REGULATION OF APOPTOSIS
    Sally Kornbluth; Fiscal Year: 2006
    ..Moreover, we will characterize additional Crk interactors (including those interacting with the Crk N-terminal SH3 domain) to further reconstruct the pathway from Crk to cell death effectors. ..
  28. Cell Cycle Regulation of Mcm Localization
    MULUYE LIKU; Fiscal Year: 2007
    ..To investigate these possibilities, I will pursue the following specific aims: Aim 1: Determine whether and how Cdc28 regulates Mcm nuclear import Aim 2: Determine whether and how Cdc28 regulates Mcm nuclear export ..
  29. Treatments for Psychogenic Nonepileptic Seizures (NES)
    W LaFrance; Fiscal Year: 2007
    ..abstract_text> ..
  30. Effectiveness of Guided Self-Help for Binge Eating
    Ruth Striegel Moore; Fiscal Year: 2007
    ..The proposed study will answer the question whether CBT- GSH is an effective early step intervention for the treatment of binge eating disorders. ..
  31. Psychosocial Determinants of Nutrient Intake in Girls
    Ruth Striegel Moore; Fiscal Year: 2004
    ..Adult weight was also measured. Results from our secondary analyses will be useful for interventions aimed at improving nutritional health. ..
  32. EDUCATIONAL SOFTWARE FOR CELL & MOLECULAR BIOLOGY
    JONATHAN MERRIL; Fiscal Year: 1992
    ....
  33. Control of menstrual bleeding disturbances in women
    Ian Fraser; Fiscal Year: 2006
    ..This study aims to explore these possibilities in large scale clinical studies, scientific study of vascular and molecular changes in endometrium and with the exploration of molecular mechanisms in mice. ..
  34. Nuclear Import Pathways for HPV Macromolecules
    JUNONA F MOROIANU; Fiscal Year: 2010
    ..Overall, the studies proposed in this renewal application will continue to advance our understanding of major nuclear import pathways relevant to the papillomavirus infection and pathogenesis. ..
  35. Xenobiotics, Lipid Peroxidation and Autoimmunity
    M Firoze Khan; Fiscal Year: 2006
    ..abstract_text> ..
  36. A Telephone Intervention for Dementia Caregivers
    Geoffrey Tremont; Fiscal Year: 2004
    ..It is hypothesized that the intervention will result in reduced caregiver burden and emotional distress, as well as improved quality of life and family functioning and increased use of community resources. ..
  37. IL3,IL5, and GM-CSF Signaling and Asthma
    Christian Schindler; Fiscal Year: 2004
    ..Specifically we propose to: 1. Further characterize StIP1. 2. Functionally characterize the STAT four-bundle-helix. 3. Explore the role of Stat5 signal decay in primary leukocytes. ..
  38. Thyroid Hormone Receptor Isoforms & Coactivators In Vivo
    Roy Weiss; Fiscal Year: 2005
    ..Such information would generate important leads in understanding the specific mechanistic aspects of TH action. ..
  39. 14-3-3 PROTEIN FUNCTION IN CELL GROWTH AND MOTILITY
    ANTHONY MUSLIN; Fiscal Year: 2001
    ..The expectation is that the results of these experiments will establish the importance of the 14-3-3 signaling molecules in cell growth regulation and development. ..
  40. PSYCHOTHERAPY AND MEDICATION FOR BINGE EATING DISORDER
    Michael Devlin; Fiscal Year: 2001
    ..Treatment will take place over a period of five months, and patients will be followed for two years after treatment. ..
  41. Redox control of Nrf2/ARE by thioredoxin and GSH
    Jason Hansen; Fiscal Year: 2005
    ..The roles of GSH and cytosolic and nuclear TRX during NRF2 activation and binding will provide an essential foundation for future developmental toxicology. ..
  42. OSTEOCLASTIC PHOSPHOTYROSYL PHOSPHATASE AND RESORPTION
    KIN HING LAU; Fiscal Year: 2002
    ....
  43. IFN-Is at the interface of Innate and Adapative Immunity
    Christian W Schindler; Fiscal Year: 2010
    ..2. Determine the unique role Stat2 exhibits in regulating MHC-II expression in macrophages 3. Explore the role SUMOylation may play in regulating the kinetics of IFN stimulated STATs. ..
  44. COLUMBIA UNIVERSITY ASTHMA AND ALLERGY CLINICAL RESEARCH
    Christian Schindler; Fiscal Year: 2005
    ..The Scientific Core will provide technical expertise and assistance in murine models of asthma and allergic immune responses. The Administrative Core will assist in organizing the Center?s activities. ..
  45. SPLENIC TOXICITY OF ANILINE
    M Firoze Khan; Fiscal Year: 2010
    ..These studies will elucidate the mechanisms of aniline-induced splenic toxicity, and will be important in devising strategies to prevent toxicity, and in risk assessment of aniline and other structurally-related aromatic amines. ..
  46. IMMUNOLOGICAL DISEASE MECHANISMS
    Sankar Ghosh; Fiscal Year: 2006
    ..These accomplishments more than fulfill the promises made in our initial application to establish an NlAlD training program in immunology. In the next five years we expect to consolidate and expand on these gains. ..
  47. Cognitive Studies of Temporal Lobe Function in Man
    Guila Glosser; Fiscal Year: 2003
    ..b) To assess the usefulness of presurgical fMRI activation measures during an allocentric spatial memory task for predicting memory performance following ATL. ..
  48. GENETIC MODEL FOR THE ROLE OF NEUROGENESIS IN ANTIDEPRESSANT RESPONSE
    ROBERT BEECH; Fiscal Year: 2007
    ..This, in turn, should allow for a more rational search for new medications for the treatment of depression, and potentially other mental illnesses as well. [unreadable] [unreadable] [unreadable]..
  49. CHOC Human Embryonic Stem Cell Culture Training Course
    Philip Schwartz; Fiscal Year: 2008
    ..The courses are held annually in the Spring at the National Human Neural Stem Cell Resource of the Neuroscience Laboratories at the Children's Hospital of Orange County Research Institute. [unreadable] [unreadable] [unreadable]..
  50. Epo-dependent JAK2 Signaling in Painful Neuropathy
    WENDY CAMPANA; Fiscal Year: 2006
    ..The experiments will provide new information on the basic mechanisms of nerve injury and pain, and there from, new rationale for development of novel neuroprotective strategies for preventing chronic neuropathic pain. ..
  51. MAP Kinase and AKT Signaling in Congestive Heart Failure
    ANTHONY MUSLIN; Fiscal Year: 2009
    ..Our findings will help to identify specific signaling mechanisms involved in the regulation of cardiac myocyte growth and metabolism. ..
  52. FLUORESCENCE-ACTIVATED CELL SORTER
    Christian Schindler; Fiscal Year: 2004
    ..abstract_text> ..
  53. Nuclear cofactors in Human Thyroid Disease
    Roy Weiss; Fiscal Year: 2007
    ..3) Determine the cause for hypersensitivity to TH. This will allow clinicians to better identify factors influencing thyroid function. ..
  54. DOXYCYCLINE FOR BLEEDING IN PROGESTIN ONLY CONTRACEPTORS
    David Archer; Fiscal Year: 2006
    ..If successful, DOX treatment could become an important adjuvant for treatment of this and possibly other inflammatory disorders effecting reproductive tract tissues. ..
  55. Regulation of Notch signaling by NKAP
    VIRGINIA SHAPIRO; Fiscal Year: 2008
    ..This proposal will focus on understanding how NKAP, a negative regulator of Notch signaling, affects lymphocyte development, activation and effector function. [unreadable] [unreadable] [unreadable]..
  56. RGS PROTEIN FUNCTION IN CARDIAC PHYSIOLOGY
    ANTHONY MUSLIN; Fiscal Year: 2008
    ..These experiments will help define the role of RGS proteins in the pathogenesis of cardiac hypertrophy and contractile dysfunction and may provide important information for the development of novel therapeutic agents. ..