Genomes and Genes
Gene Symbol: nestin
Alias: Nbla00170, nestin
Publications253 found, 100 shown here
- Distribution of nestin immunoreactivity in the normal adult human forebrainHuaiyu Gu
Department of Neurobiology and Anatomy, Sun Yat Sen University of Medical Sciences, 74 Zhongshan 2nd Road, Guangzhou 510089, PR China
Brain Res 943:174-80. 2002The distribution of nestin immunoreactivity was studied in the whole normal adult human forebrains using new anti-human nestin mouse monoclonal and rabbit polyclonal antiserum...
- Novel nuclear export signal-interacting protein, NESI, critical for the assembly of hepatitis delta virusYun Hsin Wang
Institute of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, No 1, Jen Ai Road, First Section, Taipei 100, Taiwan
J Virol 79:8113-20. 2005..These data indicate a critical role of NESI in the assembly of HDV through interaction with HDAg-L...
- Feasibility study of Nestorone-ethinylestradiol vaginal contraceptive ring for emergency contraceptionHoratio B Croxatto
Instituto Chileno de Medicina Reproductiva, Jose Ramon Gutierrez 295, Apt 3, Santiago, Chile
Contraception 73:46-52. 2006..Here, we report a Phase I clinical trial to determine the usefulness of this ring for emergency contraception. To that end, we tested the ability of this ring to interfere with ovulation when it is inserted during the follicular phase...
- Nighttime eating: a descriptive studyMartina de Zwaan
Department of Psychosomatic Medicine and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
Int J Eat Disord 39:224-32. 2006..Researchers have cogently argued for consideration of wide ranges including "subsyndromal" cases before reifying diagnostic constructs prematurely...
- A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell deathCecilia M Sahlgren
Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finlandand
EMBO J 25:4808-19. 2006The intermediate filament protein, nestin, has been implicated as an organizer of survival-determining signaling molecules...
- Tissue-specific muscle, neural and liver stem/progenitor cells reside in the bone marrow, respond to an SDF-1 gradient and are mobilized into peripheral blood during stress and tissue injuryMagda Kucia
Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202 3270, USA
Blood Cells Mol Dis 32:52-7. 2004..of this concept, we report here that mRNA of several early markers for muscle (Myf-5, Myo-D), neural (GFAP, nestin) and liver (CK19, fetoprotein) is detectable in circulating (adherent cell-depleted) peripheral blood mononuclear ..
- Expression and distribution patterns of the stem cell marker, nestin, and the stem cell renewal factor, BMI-1, in normal human nasal mucosa and nasal polypsTae Hoon Kim
Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, Korea University, Seoul, South Korea
Acta Otolaryngol 129:996-1001. 2009These results suggest that nestin and BMI-1 are candidates for stem cell markers and renewal factors in human nasal mucosa, may contribute to tissue homeostasis and differentiation in the epithelium and submucosal glands of normal nasal ..
- Analysis of VEGF, Flt-1, Flk-1, nestin and MMP-9 in relation to astrocytoma pathogenesis and progressionA Hlobilkova
Institute of pathology and Laboratory of Molecualr Pathology, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, Olomouc, CZ 775 15, Czech Republic
Neoplasma 56:284-90. 2009..vascular endothelial growth factor (VEGF), VEGF receptors (Flk-1, and Flt-1), the intermediate filamental protein nestin which plays a role in central nervous system development, and MMP-9, which belongs the family of matrix ..
- Nestin-positive stem cells in neurofibromas from patients with neurofibromatosis type 1-tumorigenic or incidental?Marinya Pongpudpunth
Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, MA 02118, USA
Am J Dermatopathol 32:574-7. 2010..Recently, we found discrete foci of melanin deposits but diffuse positivity with MART-1/MelanA in a neurofibroma from a patient with neurofibromatosis type 1 (NF1)...
- Isolation of mineralizing Nestin+ Nkx6.1+ vascular muscular cells from the adult human spinal cordDaria Mamaeva
CNRS UPR 1142, Institute of Human Genetics, 141, rue de la Cardonille, 34396 Montpellier Cedex 05, France
BMC Neurosci 12:99. 2011..We previously isolated Nestin+ Sox2+ neural multipotential cells from the adult human spinal cord using the neurosphere method (i.e...
- Multipotential nestin and Isl-1 positive mesenchymal stem cells isolated from human pancreatic isletsMichael Eberhardt
Division for Endocrinology, Diabetes and Clinical Nutrition, Department of Research, University Hospital Basel, Switzerland
Biochem Biophys Res Commun 345:1167-76. 2006Mesenchymal cells in the developing pancreas express the neural stem cell marker nestin and the transcription factor islet-1 (Isl-1)...
- Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilamentsJ Dahlstrand
Department of Molecular Genetics, Karolinska Institute, Stockholm, Sweden
J Cell Sci 103:589-97. 1992..gene expression accompany this transition out of the precursor state: transcription of the intermediate filament nestin is replaced by that of the neurofilaments...
- Identification of major cell classes in the developing mammalian nervous systemS Hockfield
J Neurosci 5:3310-28. 1985..In addition, we report a marker for another cell class present in the developing nervous system, the endothelial cells that give rise to the CNS vasculature...
- Heterogeneity of neural progenitor cells revealed by enhancers in the nestin geneP J Yaworsky
Molecular Neuroscience Program, Samuel C Johnson Medical Research Center, Scottsdale, Arizona, 85259, USA
Dev Biol 205:309-21. 1999..each requiring the cooperation of at least two independent regulatory sites, within the second intron of the rat nestin gene...
- Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinaseC M Sahlgren
Turku Centre for Biotechnology, University of Turku and Abo Akademi University, FIN 20521 Turku, Finland
J Biol Chem 276:16456-63. 2001The intermediate filament protein nestin is expressed during early stages of development in the central nervous system and in muscle tissues...
- Cdk5 regulates the organization of Nestin and its association with p35Cecilia M Sahlgren
Department of Biology, Abo Akademi University, BioCity, Finland
Mol Cell Biol 23:5090-106. 2003The intermediate filament protein nestin is characterized by its specific expression during the development of neuronal and myogenic tissues...
- Nestin is a potential mediator of malignancy in human neuroblastoma cellsSharon K Thomas
Laboratory of Neurobiology, Department of Biological Sciences, Fordham University, 441 East Fordham Road, Bronx, NY 10458, USA
J Biol Chem 279:27994-9. 2004..Likewise, overexpression of the intermediate filament nestin, a neuroectodermal stem cell marker, is linked to increased aggressiveness in several nervous system tumors...
- Nestin expression--a property of multi-lineage progenitor cells?C Wiese
In Vitro Differentiation Group, Institute of Plant Genetics and Crop Plant Research IPK Gatersleben, Corrensstrasse 3, 06466, Gatersleben, Germany
Cell Mol Life Sci 61:2510-22. 2004..In this review, we describe what is currently known about nestin, an intermediate filament first identified in neuroepithelial stem cells...
- Nestin expression by newly formed human blood vesselsJ Mokry
Department of Histology and Embryology, Charles University in Prague, Medical Faculty in Hradec Kralove, Czech Republic
Stem Cells Dev 13:658-64. 2004b>Nestin is a type VI intermediate filament protein originally described in neural stem cells. Here we report that immature endothelial cells generated in the course of angiogenesis express nestin...
- Nestin immunoreactivity of Purkinje cells in Creutzfeldt-Jakob diseaseYuji Mizuno
Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
J Neurol Sci 246:131-7. 2006b>Nestin, an intermediate filament protein, is mainly expressed in neural progenitor/stem cells in the central nervous system. Recently, we reported that nestin is expressed in Purkinje cells in patients with Creutzfeldt-Jakob disease (CJD)...
- Identification of neovasculature using nestin in colorectal cancerNobuhisa Teranishi
Department of Surgery for Organ Function and Biological Regulation, Graduate School of Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Int J Oncol 30:593-603. 2007..However, this marker detects not only newly formed, but also pre-existing large blood vessels. Nestin, a class VI intermediate filament protein, has recently received attention as a marker for detecting newly formed ..
- Roles for the stem cell associated intermediate filament Nestin in prostate cancer migration and metastasisWolfram Kleeberger
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
Cancer Res 67:9199-206. 2007The intermediate filament protein Nestin identifies stem/progenitor cells in adult tissues, but the function of Nestin is poorly understood. We investigated Nestin expression and function in common lethal cancers...
- Nestin expression correlates with nerve and retroperitoneal tissue invasion in pancreatic cancerMasao Kawamoto
Surgery for Organ and Biological Regulation Department of Surgery I, Graduate School of Medicine, Nippon Medical School, Tokyo 113 8603, Japan
Hum Pathol 40:189-98. 2009b>Nestin was first described as an intermediate filament protein expressed in neuroepithelial stem cells. Nestin expression has also been reported in brain tumors, schwannomas, gastrointestinal stromal tumors, and melanomas...
- Expression of nestin in lymph node metastasis and lymphangiogenesis in non-small cell lung cancer patientsZhenguang Chen
Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong 510080, P R China
Hum Pathol 41:737-44. 2010Stem cell marker nestin has been reported to be activated in various neoplasms, and its expression is correlated with poor prognosis. However, nestin expression in non-small cell lung cancer still remains unclear...
- Neuroepithelial stem cell marker nestin regulates the migration, invasion and growth of human gliomasToshiyuki Ishiwata
Department of Pathology, Nippon Medical School, Bunkyo ku, Tokyo 113 8602, Japan
Oncol Rep 26:91-9. 2011b>Nestin, a class VI intermediate filament protein, was originally described as a neuronal stem cell marker during central nervous system development...
- Nestin and caveolin-1 in the diagnosis of GISTsSimona Enache
Victor Babes National Institute, Bucharest, Romania
Rom J Morphol Embryol 53:41-6. 2012..Recently, it was reported that nestin and caveolin-1 are also expressed in some human sarcomas, GISTs included...
- Stem cell marker nestin is critical for TGF-β1-mediated tumor progression in pancreatic cancerHuei Ting Su
Institute of Biomedical Sciences, National Sun Yat Sen University, Kaohsiung, Taiwan 80424
Mol Cancer Res 11:768-79. 2013The stem cell marker nestin is an intermediate filament protein that plays an important role in cell integrity, migration, and differentiation...
- Intermediate filament nestin expressions in human cord blood monocytes (HCMNCs)Y Ha
Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea
Acta Neurochir (Wien) 145:483-7. 2003b>Nestin is an intermediate protein and a well-known specific neural stem cell antigen. Some bone marrow stem cells can generate not only blood cells but also neurons and glial cells under specific culture conditions...
- Expression of nestin in Purkinje cells in patients with Creutzfeldt-Jakob diseaseYuji Mizuno
Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
Neurosci Lett 352:109-12. 2003b>Nestin is one of the intermediate filament proteins and mainly expressed during the development of the central nervous system...
- Expression of nestin in rat and human glomerular podocytesM Ishizaki
Department of Pathology I, Nippon Medical School, Tokyo, Japan
J Submicrosc Cytol Pathol 38:193-200. 2006b>Nestin is a neuroepithelial precursor cell marker expressed in a variety of human cell types during development. However, no information exists on the expression of nestin in mature glomeruli as well as during the glomerular development...
- Expression of nestin mRNA is a differentiation marker in thyroid tumorsHiroya Yamada
Department of Laboratory Medicine, Osaka University Medical School, 2 2 D2, Yamadaoka, Suita, Osaka 565 0871, Japan
Cancer Lett 280:61-4. 2009b>Nestin is a maker that identifies stem cells in some adult tissues, and its expression is believed to relate to malignancy in cancer cells...
- The stem cell marker nestin predicts poor prognosis in human melanomaFranca Piras
Department of Cytomorphology, University of Cagliari, Cittadella Universitaria, Monserrato CA, Italy
Oncol Rep 23:17-24. 2010..b>Nestin and CD133 have been described as markers of melanocytic stem cells...
- Transplantation of clonal neural precursor cells derived from adult human brain establishes functional peripheral myelin in the rat spinal cordY Akiyama
Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, 060 8543, Japan
Exp Neurol 167:27-39. 2001..Sections of removed brain indicated that nestin-positive cells were found predominantly in the subventricular zone around the anterior horns of the lateral ..
- Nestin promoter/enhancer directs transgene expression to precursors of adult generated periglomerular neuronsRobert D Beech
Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor, New Haven, CT 06508, USA
J Comp Neurol 475:128-41. 2004..In the present study, we used the nestin promoter and enhancer to direct expression of the tetracycline transactivator (tTA)...
- Angiogenic endothelium-specific nestin expression is enhanced by the first intron of the nestin geneMasanori Aihara
Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
Lab Invest 84:1581-92. 2004b>Nestin is a member of intermediate filaments abundantly expressed in neural stem cells and glioblastomas. The nestin gene has four exons and three introns, and neural cell-specific expression is regulated by the second intron...
- Granular cell tumours of the gastrointestinal tract: expression of nestin and clinicopathological evaluation of 11 patientsJ R Parfitt
Department of Pathology, London Health Sciences Centre, University of Western Ontario, London, Canada
Histopathology 48:424-30. 2006..b>Nestin is a recently identified intermediate filament protein that is expressed in neuroectodermal stem cells and ..
- Yeast heat shock mRNAs are exported through a distinct pathway defined by Rip1pC A Saavedra
Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Genes Dev 11:2845-56. 1997....
- Structural heterogeneity of the Fe(2+)-N epsilon (HisF8) bond in various hemoglobin and myoglobin derivatives probed by the Raman-active iron histidine stretching modeH Gilch
Institute of Experimental Physics, University of Bremen, Germany
Biophys J 65:1470-85. 1993..Quaternary and tertiary transitions of the protein alter the population of these substates thus giving rise to a redistribution of the VFe-HiS sublines which shifts the corresponding peak frequency to higher values...
- The exclusion of non-English-speaking persons from researchS M Frayne
Section of General Internal Medicine, Boston University School of Medicine, MA, USA
J Gen Intern Med 11:39-43. 1996....
- Nocturnal eating: prevalence and features in 120 insomniac referralsR Manni
Neurological Institute C. Mondino, University of Pavia, Italy
Sleep 20:734-8. 1997..g. associated with sleepwalking, restless legs syndrome, obstructive sleep apnea, etc.) and with eating disorders such as daytime binge eating...
- Antagonistic effects of NES and NLS motifs determine S. cerevisiae Rna1p subcellular distributionW Feng
Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Cell Sci 112:339-47. 1999..The data support the hypothesis that Rna1p exists on both sides of the nuclear membrane, perhaps regulating the Ran-GTP/Ran-GDP gradient, participating in a complete RanGTPase nuclear cycle or serving a novel function...
- Neurological soft signs in schizophrenia: assessment and correlatesF Mohr
Hospital Haar, Germany
Eur Arch Psychiatry Clin Neurosci 246:240-8. 1996..This close association of psychomotor and cognitive dysfunctions may be seen as related to the frequently discussed dysfunctions of the prefrontal cortex or the neurointegrative deficit postulated by Meehl...
- Body water handling in response to hypertonic-saline induced diuresis in fasting northern elephant seal pups (Mirounga angustirostris)Rudy M Ortiz
Department of Biology, University of California, CA 95064, Santa Cruz, USA
Comp Biochem Physiol A Mol Integr Physiol 134:423-8. 2003..This water recycling mechanism may allow pups to avoid negative perturbations in body water as they initiate feeding in a marine environment following the fast...
- Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-betaB R Henderson
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, England
J Mol Biol 274:693-707. 1997..The series of interactions we describe provide a novel pathway for the import of Rev across the nuclear pore complex, and a mechanism for its release into the nucleoplasm...
- Presence of a functional but dispensable nuclear export signal in the HTLV-2 Tax proteinSébastien A Chevalier
Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, Paris, France
Retrovirology 2:70. 2005..We have recently demonstrated that Tax1 and Tax2 display different subcellular localization and that residues 90-100 are critical for this process. We investigate in the present report, whether Tax2 also possesses a functional NES...
- A nuclear export signal in Kap95p is required for both recycling the import factor and interaction with the nucleoporin GLFG repeat regions of Nup116p and Nup100pM K Iovine
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Cell Biol 137:797-811. 1997..This finding highlights an important role for a subfamily of GLFG nucleoporins in nuclear export processes...
- The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear exportM Neville
Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02254, USA
Curr Biol 7:767-75. 1997..Crm1p has recently been shown to contribute to nuclear export in vertebrate systems. Here, we have studied this mechanism of nuclear to cytoplasmic transport...
- Contraceptive vaginal rings releasing Nestorone and ethinylestradiol: a 1-year dose-finding trialIrving Sivin
Center for Biomedical Research, Population Council, New York, NY 10021, USA
Contraception 71:122-9. 2005..Clinical performance and adverse event profiles indicate that each of these 1-year NES/EE rings, used on a 21-day-in and 7-day-out regimen, provided women effective, acceptable and safe long-acting contraception under their own control...
- Serum Nestorone and ethinyl estradiol levels, and ovulation inhibition in women using three different dosage combinations of a Nestorone progestogen-ethinyl estradiol contraceptive vaginal ring on a bleeding-signaled regimenIan S Fraser
Department of Obstetrics and Gynaecology, University of Sydney, Sydney NSW 2006, Australia
Contraception 72:40-5. 2005....
- Clinical performance and menstrual bleeding patterns with three dosage combinations of a Nestorone progestogen/ethinyl estradiol contraceptive vaginal ring used on a bleeding-signaled regimenEdith Weisberg
Sydney Center for Reproductive Health Research, Research Division of FPA Health, NSW 2131, Australia
Contraception 72:46-52. 2005..Ring removal times were signaled by menstrual events. Bleeding patterns, adverse events, patterns of use and continuation rates were the principal parameters evaluated...
- Opportunity for change in the future roles for the health library and information professional: meeting the challenges in NHS ScotlandGerry Maclean
Knowledge Services Group, NHS Education for Scotland, 1st Floor, Clifton House, Clifton Place, Glasgow G3 7LD, UK
Health Info Libr J 23:32-8. 2006..The Knowledge Services Group also supports the national development of library services to NHS Scotland...
- Longitudinal study on potential neurotoxic effects of aluminium: I. Assessment of exposure and neurobehavioural performance of Al welders in the train and truck construction industry over 4 yearsE Kiesswetter
Institute for Occupational Physiology, University of Dortmund, Ardeystr 67, 44139 Dortmund, Germany
Int Arch Occup Environ Health 81:41-67. 2007....
- The safety of intravenous diuretics alone versus diuretics plus parenteral vasoactive therapies in hospitalized patients with acutely decompensated heart failure: a propensity score and instrumental variable analysis using the Acutely Decompensated Heart Maria Rosa Costanzo
Midwest Heart Foundation, Lombard, IL, USA
Am Heart J 154:267-77. 2007..Significant concerns have been expressed regarding risks and benefits of individual therapies, especially nesiritide (NES), but few studies have compared the relative safety of varied intravenous therapies on clinical outcomes...
- Relative progestational and androgenic activity of four progestins used for male hormonal contraception assessed in vitro in relation to their ability to suppress LH secretion in the castrate male ratBarbara J Attardi
BIOQUAL, Inc Division of Reproductive Endocrinology and Toxicology, 9600 Medical Center Dr, Rockville, MD 20850, USA
Mol Cell Endocrinol 328:16-21. 2010..2mg/kg/day; and NES and CPA showed no or minimal LH suppression at doses up to 3.2mg/kg/day. We concluded, therefore, that suppression of LH is correlated with androgenic, rather than progestational, potency of the synthetic progestins...
- New progestagens for contraceptive useRegine Sitruk-Ware
Rockefeller University and Population Council, New York, NY, USA
Hum Reprod Update 12:169-78. 2006..Given their pharmacological properties, it is likely that the new progestins may have neutral effects on metabolic or vascular risks. However, this hypothesis must be confirmed in large clinical trials...
- Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactorsA Kiss
Institute for Molecular Virology, Saint Louis University School of Medicine, 3681 Park Avenue, Saint Louis, MO 63108, USA
Virology 314:591-600. 2003..These results suggest a physiological role for hNup98 in modulating Rev-dependent RNA export during HIV infection...
- The value of provocation methods in patients suspected of having non-epileptic seizuresN Dericioglu
Department of Neurology, Hacettepe University Hospital, Ankara, Turkey
Seizure 8:152-6. 1999..We claim that not all patients suspected of having NES need long-term video-EEG monitoring and almost half (54.2%) of the cases can be eliminated by seizure induction with some provocative techniques...
- Night eating syndrome and nocturnal snacking: association with obesity, binge eating and psychological distressS L Colles
Centre for Obesity Research and Education, The Alfred Hospital, Monash University, Melbourne, Victoria, Australia
Int J Obes (Lond) 31:1722-30. 2007..This study aimed to investigate the clinical significance of NES and nocturnal snacking by exploring the relationship between NES and (1) obesity, (2) binge eating disorder (BED) and (3) psychological distress...
- Drosophila lysophospholipid acyltransferases are specifically required for germ cell developmentJosefa Steinhauer
Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
Mol Biol Cell 20:5224-35. 2009..Our findings suggest that lysophospholipid acyltransferase activity is essential for germline development and could provide a mechanistic explanation for the etiology of the human MBOAT1 mutation...
- Night eating syndrome is associated with depression, low self-esteem, reduced daytime hunger, and less weight loss in obese outpatientsM E Gluck
New York Obesity Research Center and Department of Medicine, St Luke s Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York 10025, USA
Obes Res 9:264-7. 2001..The objective of this study was to assess the relationship between the night eating syndrome (NES), measures of depression and self-esteem, test meal intake, and weight loss in obese participants...
- A comparison of personality disorder characteristics of patients with nonepileptic psychogenic pseudoseizures with those of patients with epilepsyCynthia L Harden
Comprehensive Epilepsy Center, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Epilepsy Behav 14:481-3. 2009....
- Hospital CEOs, CFOs, and nurse executives: opportunities for a new allianceR B Dwore
University of Utah, USA
J Healthc Manag 43:136-51; discussion 152-4. 1998..Together, CEOs, CFOs, and NEs can successfully take hospitals into the future by leading them in ongoing learning and change...
- Nuclear import of Upf3p is mediated by importin-alpha/-beta and export to the cytoplasm is required for a functional nonsense-mediated mRNA decay pathway in yeastRenee L Shirley
Laboratories of Genetics and Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706, USA
Genetics 161:1465-82. 2002..To explain these results, we suggest that the mutations in NES-A that impair nuclear export cause additional defects in the function of Upf3p that are not rectified by restoration of export alone...
- Carboxyl-terminal basic amino acids in the X domain are essential for the nuclear import of phospholipase C delta1Masashi Okada
Department of Life Science, Faculty of Science, Himeji Institute of Technology, Harima Science Garden City, Hyogo 678 1297, Japan
Genes Cells 7:985-96. 2002..Since nucleocytoplasmic shuttling of a molecule is generally regulated by a balance between its NES and the nuclear localization signal (NLS), we examined whether PLCdelta1 contains an NLS sequence...
- Binge eating disorder and night eating syndrome in adults with type 2 diabetesKelly C Allison
Department of Psychiatry, University of Pennsylvania School of Medicine, 3535 Market Street, Suite 3021, Philadelphia, PA 19104 3309, USA
Obesity (Silver Spring) 15:1287-93. 2007..To determine the prevalence of binge eating disorder (BED) and night eating syndrome (NES) among applicants to the Look AHEAD (Action for Health in Diabetes) study...
- Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cellsMaria Lombardi
Dipartimento di Patologia Generale, Il Università di Napoli, 80138 Naples, Italy
J Cell Biol 182:327-40. 2008..In conclusion, estradiol-induced AKT-dependent phosphorylation of FKHR drives its association with ERalpha, thereby triggering complex export from the nucleus necessary for initiation of DNA synthesis and S phase entry...
- The peer review pilot project: a potential system to support GP appraisal in NHS Scotland?Jill Murie
NHS Education for Scotland, Glasgow, UK
Educ Prim Care 20:34-40. 2009..A comparative review of different systems in other countries suggests further research is necessary to provide greater evidence of feasibility, acceptability and educational benefit of such a system in the UK...
- Mechanisms of malarial anaemia: potential involvement of the Plasmodium falciparum low molecular weight rhoptry-associated proteinsNancy W Awah
Wenner Gren Institute, Department of Immunology, Svante Arrhenius väg 20C, Stockholm University, SE 10 691 Stockholm, Sweden
Acta Trop 112:295-302. 2009..These observations could therefore have implications in the design, development and deployment of future therapeutic interventions against malaria...
- Effect of differently induced plasma norepinephrine increments on norepinephrine sulfate formationGunther Strobel
Dept of Sports Medicine, Free University of Berlin, Clayallee 225C, 14195 Berlin, Germany
Life Sci 71:55-65. 2002..Secondly, plasma NE may be a useful additional marker for NES release...
- Immunoglobulin responses of northern elephant and Pacific harbor seals naturally infected with Otostrongylus circumlitusJocelyn G Elson-Riggins
Department of Biology, University of California, Riverside, California 92521, USA
J Wildl Dis 40:466-75. 2004..The banding patterns suggest that O. circumlitus nematodes die and disintegrate in PHS and NES and that NES of 1 yr and older and most PHS respond differently to the ES glands than 2- to 9-mo-old NES...
- Activation of transcription factor AP-1 and mitogen-activated protein kinases in aniline-induced splenic toxicityM Firoze Khan
Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
Toxicol Appl Pharmacol 210:86-93. 2006..The observed sequence of events subsequent to aniline exposure could regulate genes that lead to fibrogenic and/or tumorigenic response in the spleen...
- Nucleocytoplasmic shuttling of phospholipase C-delta1: a link to Ca2+Hitoshi Yagisawa
Graduate School of Life Science, University of Hyogo, Harima Science Garden City, Hyogo 678 1297, Japan
J Cell Biochem 97:233-43. 2006..The consequence of the nuclear accumulation of PLC is also discussed...
- Factor structure of the Neurological Evaluation Scale in a predominantly African American sample of patients with schizophrenia, unaffected relatives, and non-psychiatric controlsMichael T Compton
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 49 Jesse Hill Jr Drive, S E, Atlanta, GA 30303, USA
Schizophr Res 84:365-77. 2006..This study aimed to identify latent factors of the most widely used scale to measure neurological soft signs, the Neurological Evaluation Scale (NES), in a sample of schizophrenia patients, their relatives, and non-psychiatric controls...
- MMPI-2 profiles of persons with multiple chemical sensitivityLaurence M Binder
Oregon Health and Sciences University, Beaverton, OR, USA
Clin Neuropsychol 20:848-57. 2006..We conclude that MMPI-2 data, obtained from people seeking financial compensation, indicate that there is a strong psychological component to MCS symptoms...
- Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout miceM V Schmidt
Max Planck Institute of Psychiatry, RG Molecular Stress Physiology, Kraepelinstr 2 10, 80804 Munich, Germany
Eur J Neurosci 24:2291-8. 2006....
- Nuclear export of human papillomavirus type 31 E1 is regulated by Cdk2 phosphorylation and required for viral genome maintenanceAmelie Fradet-Turcotte
Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
J Virol 84:11747-60. 2010..On the basis of these results, we propose that nuclear export of E1 is required, at least in part, to limit accumulation of this viral helicase in the nucleus in order to prevent its detrimental effect on cellular proliferation...
- Nucleocytoplasmic distribution and dynamics of the autophagosome marker EGFP-LC3Kimberly R Drake
Department of Molecular Physiology and Biophysics, Vanderbilt School of Medicine, Nashville, Tennessee, United States of America
PLoS ONE 5:e9806. 2010..Instead, incorporation of soluble EGFP-LC3 into large macromolecular complexes within both the cytoplasm and nucleus may prevent its rapid equilibrium between the two compartments...
- A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleusF Stutz
Department of Biology, Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02254, USA
Mol Cell Biol 16:7144-50. 1996..The results suggest that Rev and cellular mediators of RNA export can interact with multiple components of the nuclear pore complex during transport, analogous to the proposed mode of action of the nuclear protein import receptor...
- Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1H P Bogerd
Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
J Virol 72:8627-35. 1998..In addition, these data identify a novel and highly potent inhibitor of leucine-rich NES-dependent nuclear export...
- Non-epileptic seizures of the elderlyChristoph Kellinghaus
Department of Neurology, The Cleveland Clinic Foundation, Ohio, USA
J Neurol 251:704-9. 2004..To characterize non-epileptic seizures (NES) in the elderly and compare their features with NES of a younger control group...
- [Changes of electroencephalographic background patterns and serum neuron specific enolase levels in neonates with hypoxic-ischemic encephalopathy]Hong Qing Dai
Department of Pediatrics, People s Hospital of Wugang, Wugang, Hunan 422400, China
Zhongguo Dang Dai Er Ke Za Zhi 11:173-6. 2009....
- Nuclear export of proteins in plants: AtXPO1 is the export receptor for leucine-rich nuclear export signals in Arabidopsis thalianaD Haasen
University of Freiburg, Institute for Biology II, Cell Biology, Schänzlestr 1, D 79104 Freiburg, Germany
Plant J 20:695-705. 1999..In BY-2 protoplasts the NES of AtRanBP1a is functionally indistinguishable from the Rev NES. Our results demonstrate that the machinery for the nuclear export of proteins is functionally conserved in plants...
- Multiple strategies of schistosomes to meet their requirements in the intermediate snail hostM de Jong-Brink
Research Institute Neurosciences, Vrije Universiteit, Faculty of Biology, Amsterdam, The Netherlands
Parasitology 123:S129-41. 2001..The physiological changes in the snail host are obviously of vital importance for the parasites, since they make use of different strategies to bring them about...
- Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degenerationLeen Hulshagen
Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Belgium
J Neurosci 28:4015-27. 2008..These anomalies of myelinated axons were already present in juvenile mice but aggravated in adulthood. Together, loss of CNS peroxisomal metabolism both affects myelin sheaths and axonal integrity possibly via independent pathways...
- Ovarian function during use of vaginal rings delivering three different doses of NestoroneV Brache
PROFAMILIA, Santo Domingo, Dominican Republic
Contraception 63:257-61. 2001..We conclude that the 50 and 75 microg/day NES rings provide adequate ovulation inhibition without hypoestrogenism, while the 100 microg/day ring may deliver an unnecessarily high dose...
- Chronic ischemic monomelic neuropathy from critical limb ischemiaD H Weinberg
Department of Neurology, Tufts University School of Medicine, St Elizabeth s Medical Center, Boston, MA 02135, USA
Neurology 57:1008-12. 2001..To describe the peripheral neuropathy resulting from chronic and critical arterial leg ischemia...
- A nuclear export signal prevents Saccharomyces cerevisiae Hsp70 Ssb1p from stimulating nuclear localization signal-directed nuclear transportN Shulga
Department of Biology, University of Rochester, Rochester, New York 14627, USA
J Biol Chem 274:16501-7. 1999..We conclude that the differential function of Ssa1p and Ssb1p in nuclear transport is due to the NES-directed export of the Ssb1p and not to functional differences in their ATPase or peptide binding domains...
- The NES-Crm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiaeM Neville
Howard Hughes Medical Institute, Department of Biology, MS008 Brandeis University, Waltham, MA 02454, USA
EMBO J 18:3746-56. 1999..cerevisiae. We conclude that Crm1p structure and function is conserved from S.cerevisiae to man...
- Nuclear envelope associated protein that binds telomeric DNAsO I Podgornaya
Institute of Cytology RAS, St Petersburg, Russia
Mol Reprod Dev 57:16-25. 2000..This is the first clear evidence of a protein, which could be responsible for the attachment of telomeres to the nuclear membrane...
- A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylationY Zhang
Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics, and Program in Molecular Biology and Biotechnology, University of North Carolina at Chapel Hill, NC 27599 7295, USA
Science 292:1910-5. 2001..Serine-15-phosphorylated p53 induced by ultraviolet irradiation was not exported. Thus, DNA damage-induced phosphorylation may achieve optimal p53 activation by inhibiting both MDM2 binding to, and the nuclear export of, p53...
- A masked NES in INI1/hSNF5 mediates hCRM1-dependent nuclear export: implications for tumorigenesisErrol Craig
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
EMBO J 21:31-42. 2002..These observations demonstrate that INI1 has a masked NES that mediates regulated hCRM1/exportin1-dependent nuclear export and we propose that mutations that cause deregulated nuclear export of the protein could lead to tumorigenesis...
- Satisfactory completion of dental vocational training in Scotland: a system of assessmentL Prescott-Clements
NHS Education for Scotland, The Lister, 11 Hill Square, Edinburgh EH8 9DR
Br Dent J . 2003..During the life of this project the argument for introducing assessment of DVT and General Professional Training (GPT) has become ever stronger...
- Neurological soft signs in adolescents with first episode psychosisArantzazu Zabala
Unidad de Adolescentes, Departamento de Psiquiatria, Hospital General Universitario Gregorio Maranon, C Ibiza 43, 28009 Madrid, Spain
Eur Psychiatry 21:283-7. 2006..We did not find a clear pattern of NSS that distinguished schizophrenia from other psychoses...
- Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injurySeiji Okada
Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Nat Med 12:829-34. 2006..These results suggest that Stat3 is a key regulator of reactive astrocytes in the healing process after SCI, providing a potential target for intervention in the treatment of CNS injury...
- A paradigm for facilitating pharmacotherapy at a distance: sertraline treatment of the night eating syndromeAlbert J Stunkard
Department of Psychiatry Weight and Eating Disorders Program, University of Pennsylvania School of Medicine, Philadelphia, USA
J Clin Psychiatry 67:1568-72. 2006..To test a novel method of facilitating pharmacotherapy at a distance and assess the effectiveness of sertraline for the treatment of night eating syndrome (NES)...
- Differential regulation of CuZnSOD expression in rat brain by acute and/or chronic stressDRAGANA FILIPOVIC
Laboratory of Molecular Biology and Endocrinology, Institute of Nuclear Sciences Vinca, P O Box 522 090, 11000, Belgrade, Serbia
Cell Mol Neurobiol 29:673-81. 2009..The results suggest that different stress models exert a different degree of influence on mRNA and protein level of CuZnSOD in both brain structures as well as serum corticosterone...
- [Immunohistochemical demonstration of mutant nucleophosmin in acute myeloid leukemia: biological and clinical features related to NPMc expression]Judit Bedekovics
Debreceni Egyetem, Orvos és Egészségtudományi Centrum, Patológiai Intézet, Debrecen
Orv Hetil 150:1031-5. 2009..These results are in agreement with previous studies. In conclusion, immunohistochemistry is well applicable for the identification of NPM mutated AML in the daily hematopathology practice...
- Nestin expression in glial and neuronal progenitors of the developing human spinal gangliaKatarina Vukojevic
Department of Anatomy, Histology and Embryology, School of Medicine, University of Split, 21000 Split, Croatia
Gene Expr Patterns 10:144-51. 2010Expression of the neural crest marker nestin was studied in glial and neuronal progenitors of developing human spinal ganglia using immunohistochemistry in 10 conceptuses, 5-10 weeks old...
- Nocturnal eating predicts tooth loss among adults: results from the Danish MONICA studyJennifer D Lundgren
Department of Psychology, University of Missouri Kansas City, 4825 Troost Avenue, Ste 124, Kansas City, MO 64110, United States
Eat Behav 11:170-4. 2010..0001). In sum, nocturnal eating contributes to tooth loss. Treatment providers should encourage good oral health care practices to reduce the risk of tooth loss associated with nocturnal eating...
- The efficiency of electrical stimulation to counteract the negative effects of β-agonists on meat tenderness of feedlot cattleM Hope-Jones
Department of Animal and Wildlife Sciences, University of Pretoria, Pretoria, 0002, South Africa
Meat Sci 86:699-705. 2010..ES can therefore be implemented to improve meat tenderness in zilpaterol supplemented steers, although steers without zilpaterol will still have an advantage in final tenderness...
- Subcellular sites of the signal transduction and degradation of phytochrome AGabriela Toledo-Ortiz
Department of Botany, Graduate School of Science, Kyoto University, Kyoto, 606 8502 Japan
Plant Cell Physiol 51:1648-60. 2010..In addition, a detailed time course analysis of phyA-GFP and phyA-GFP-NLS responses revealed that they were almost indistinguishable, raising the question of the physiological relevance of phyA cytoplasmic retention in darkness...
- Lizabeth A Allison; Fiscal Year: 2015....
- Development of Small Molecule Crm-1 Inhibitor for Pancreatic Cancer TherapyRamzi M Mohammad; Fiscal Year: 2013..Our newly developed KPT-SINE's are highly specific, orally active drugs with excellent pharmacokinetic parameters and hold promise against deadly pancreatic cancer. ..
- Alberto J Espay; Fiscal Year: 2015..Ultimately, the candidate will be equipped to become a successful independent investigator, advancing the knowledge and management of a largely neglected but promising group of disorders. ..
- REGULATION OF NUCLEAR PORE COMPLEX ASSEMBLYSusan R Wente; Fiscal Year: 2011..Knowledge of how nuclear pore complexes are assembled and function will be important for finding therapeutic strategies to regulate nuclear transport in disease states and moderate viral proliferation/pathogenesis. ..
- Zijie Sun; Fiscal Year: 2015..Insights into new diagnostic markers, therapeutic targets and approaches for prostate cancer and other tumors are expected. ..
- Carol Prives; Fiscal Year: 2016..We will elucidate the mechanism by which MdmX increases Mdm2 and Wip1 expression, via increasing p53 binding to their promoters. Finally we will validate our findings in cells from MdmX null mice. ..
- Role of Ubp-M and H2A deubiquitination in chromatin and cellular functionHengbin Wang; Fiscal Year: 2012..However, due to the amount of work in this application and the uncertain outcome of these experiments, we did not list these experiments as a Specific Aim. ..
- REGINE SITRUK WARE; Fiscal Year: 2016..SA2: Unravel molecular mechanism(s) by which adjudin-IMB disrupts adhesion protein complexes at the apical ectoplasmic specialization. SA3: Complete toxicity program to prepare for clinical use in men. ..
- Mechanism and regulation of LULL 1-directed NE enrichment of TorsinAABIGAIL BUCHWALTER VANDERHEYDEN; Fiscal Year: 2011..In accordance with the mission of the NIH, the main goal of these Aims is to understand the cellular function of a disease-associated protein in order to gain an understanding of the molecular mechanism of a disease. ..
- Investigation of influenza virulence mediated by the NS1A proteinDIANA NOAH; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATHAlice Sheridan; Fiscal Year: 2005..A better understanding of these events may allow us to develop therapies to better treat these incapacitating and costly diseases. ..
- VALIDITY OF COMPUTERIZED TESTS IN OCCUPATIONAL SETTINGSRoberta White; Fiscal Year: 1993....
- Akt Intracellular Localization in Thyroid CancerMatthew Ringel; Fiscal Year: 2009..abstract_text> ..
- Regulation of the Spindle Checkpoint Protein Bub1pYANIRA GONZALEZ; Fiscal Year: 2009..Taken together, these studies will provide insight in how the intracellular localization and function of Bublp is regulated. ..
- Nematode UNC-98 functions in focal adhensions and nucleiGUY BENIAN; Fiscal Year: 2009..abstract_text> ..
- Heparan sulfate in neural developmentYu Yamaguchi; Fiscal Year: 2007..We will perform histological, cell biological, and physiological analyses to determine the physiological role of HS in CNS synapses. ..
- CIITA and MHC II TranscriptionBORIS PETERLIN; Fiscal Year: 2007..Collectively, these studies will reveal the normal physiology of CIITA, why it oligomerizes and shuttles, and create new tools to manipulate the immune response in health and disease. ..
- Regulation of Homeodomain Nuclear TranslocationChristopher Bonin; Fiscal Year: 2002..We also believe that the characterization of factors required for regulating subcellular localization of Exd may lead to the identification of other proteins that rely on this process for their regulation. ..
- Mechanism of Constitutive NF-kappa B ActivityShigeki Miyamoto; Fiscal Year: 2007..They may also reveal N-NES-mediated nuclear export of IkappaBalpha as a rational therapeutic target to generally disrupt constitutive NF-kappaB activation to induce cell death or chemo/radiosensitization in human cancer. ..
- Intracellular Localization of HIV-1 RNAs by Rev&MatrixMichael Green; Fiscal Year: 2005..Finally, our results suggest a novel method for inhibiting the activity of any mRNA. This "mRNA nuclear entrapment" strategy will be developed and tested using HIV-1 replication as a model system. ..
- STABILITY OF INDIVIDUAL DIFFERENCESDUANE ALWIN; Fiscal Year: 2000..Estimates of these components will be obtained using structural equation analysis of latent growth curves employing a variety of different model specifications. ..
- AR intracellular trafficking in prostate cancerZhou Wang; Fiscal Year: 2009..5. Characterize the role of HSP90 in NES-AR action. We will test if HSP90 directly interacts with NES-AR and/or influences the nuclear export machinery. ..
- The Prevalence of two eating disordersAlbert Stunkard; Fiscal Year: 2003..This information will be gathered upon subjects' entry into the Look AHEAD trial and again at six months and one year into treatment to assess the stability of the diagnosis. ..
- THE NIGHT EATING SYNDROMEAlbert Stunkard; Fiscal Year: 2005..She will develop a manual for the treatment of the NES in consultation with the Beck Institute and will test its efficacy. ..
- CLINICAL AND EXPERIMENTAL STUDY OF HUMAN OBESITYAlbert Stunkard; Fiscal Year: 2002..Our ultimate objective is to identify behaviors that contribute to adiposity and that might be modified in programs of prevention and treatment. ..
- COMMON FEATURES OF REV LIKE VIRAL REGULATORY PROTIENSThomas Hope; Fiscal Year: 2001..This basic knowledge may lay the groundwork for novel therapeutic approaches targeting Rev function. ..
- REGULATION OF APOPTOSISSally Kornbluth; Fiscal Year: 2006..Moreover, we will characterize additional Crk interactors (including those interacting with the Crk N-terminal SH3 domain) to further reconstruct the pathway from Crk to cell death effectors. ..
- Cell Cycle Regulation of Mcm LocalizationMULUYE LIKU; Fiscal Year: 2007..To investigate these possibilities, I will pursue the following specific aims: Aim 1: Determine whether and how Cdc28 regulates Mcm nuclear import Aim 2: Determine whether and how Cdc28 regulates Mcm nuclear export ..
- Treatments for Psychogenic Nonepileptic Seizures (NES)W LaFrance; Fiscal Year: 2007..abstract_text> ..
- Effectiveness of Guided Self-Help for Binge EatingRuth Striegel Moore; Fiscal Year: 2007..The proposed study will answer the question whether CBT- GSH is an effective early step intervention for the treatment of binge eating disorders. ..
- Psychosocial Determinants of Nutrient Intake in GirlsRuth Striegel Moore; Fiscal Year: 2004..Adult weight was also measured. Results from our secondary analyses will be useful for interventions aimed at improving nutritional health. ..
- EDUCATIONAL SOFTWARE FOR CELL & MOLECULAR BIOLOGYJONATHAN MERRIL; Fiscal Year: 1992....
- Control of menstrual bleeding disturbances in womenIan Fraser; Fiscal Year: 2006..This study aims to explore these possibilities in large scale clinical studies, scientific study of vascular and molecular changes in endometrium and with the exploration of molecular mechanisms in mice. ..
- Nuclear Import Pathways for HPV MacromoleculesJUNONA F MOROIANU; Fiscal Year: 2010..Overall, the studies proposed in this renewal application will continue to advance our understanding of major nuclear import pathways relevant to the papillomavirus infection and pathogenesis. ..
- Xenobiotics, Lipid Peroxidation and AutoimmunityM Firoze Khan; Fiscal Year: 2006..abstract_text> ..
- A Telephone Intervention for Dementia CaregiversGeoffrey Tremont; Fiscal Year: 2004..It is hypothesized that the intervention will result in reduced caregiver burden and emotional distress, as well as improved quality of life and family functioning and increased use of community resources. ..
- IL3,IL5, and GM-CSF Signaling and AsthmaChristian Schindler; Fiscal Year: 2004..Specifically we propose to: 1. Further characterize StIP1. 2. Functionally characterize the STAT four-bundle-helix. 3. Explore the role of Stat5 signal decay in primary leukocytes. ..
- Thyroid Hormone Receptor Isoforms & Coactivators In VivoRoy Weiss; Fiscal Year: 2005..Such information would generate important leads in understanding the specific mechanistic aspects of TH action. ..
- 14-3-3 PROTEIN FUNCTION IN CELL GROWTH AND MOTILITYANTHONY MUSLIN; Fiscal Year: 2001..The expectation is that the results of these experiments will establish the importance of the 14-3-3 signaling molecules in cell growth regulation and development. ..
- PSYCHOTHERAPY AND MEDICATION FOR BINGE EATING DISORDERMichael Devlin; Fiscal Year: 2001..Treatment will take place over a period of five months, and patients will be followed for two years after treatment. ..
- Redox control of Nrf2/ARE by thioredoxin and GSHJason Hansen; Fiscal Year: 2005..The roles of GSH and cytosolic and nuclear TRX during NRF2 activation and binding will provide an essential foundation for future developmental toxicology. ..
- OSTEOCLASTIC PHOSPHOTYROSYL PHOSPHATASE AND RESORPTIONKIN HING LAU; Fiscal Year: 2002....
- IFN-Is at the interface of Innate and Adapative ImmunityChristian W Schindler; Fiscal Year: 2010..2. Determine the unique role Stat2 exhibits in regulating MHC-II expression in macrophages 3. Explore the role SUMOylation may play in regulating the kinetics of IFN stimulated STATs. ..
- COLUMBIA UNIVERSITY ASTHMA AND ALLERGY CLINICAL RESEARCHChristian Schindler; Fiscal Year: 2005..The Scientific Core will provide technical expertise and assistance in murine models of asthma and allergic immune responses. The Administrative Core will assist in organizing the Center?s activities. ..
- SPLENIC TOXICITY OF ANILINEM Firoze Khan; Fiscal Year: 2010..These studies will elucidate the mechanisms of aniline-induced splenic toxicity, and will be important in devising strategies to prevent toxicity, and in risk assessment of aniline and other structurally-related aromatic amines. ..
- IMMUNOLOGICAL DISEASE MECHANISMSSankar Ghosh; Fiscal Year: 2006..These accomplishments more than fulfill the promises made in our initial application to establish an NlAlD training program in immunology. In the next five years we expect to consolidate and expand on these gains. ..
- Cognitive Studies of Temporal Lobe Function in ManGuila Glosser; Fiscal Year: 2003..b) To assess the usefulness of presurgical fMRI activation measures during an allocentric spatial memory task for predicting memory performance following ATL. ..
- GENETIC MODEL FOR THE ROLE OF NEUROGENESIS IN ANTIDEPRESSANT RESPONSEROBERT BEECH; Fiscal Year: 2007..This, in turn, should allow for a more rational search for new medications for the treatment of depression, and potentially other mental illnesses as well. [unreadable] [unreadable] [unreadable]..
- CHOC Human Embryonic Stem Cell Culture Training CoursePhilip Schwartz; Fiscal Year: 2008..The courses are held annually in the Spring at the National Human Neural Stem Cell Resource of the Neuroscience Laboratories at the Children's Hospital of Orange County Research Institute. [unreadable] [unreadable] [unreadable]..
- Epo-dependent JAK2 Signaling in Painful NeuropathyWENDY CAMPANA; Fiscal Year: 2006..The experiments will provide new information on the basic mechanisms of nerve injury and pain, and there from, new rationale for development of novel neuroprotective strategies for preventing chronic neuropathic pain. ..
- MAP Kinase and AKT Signaling in Congestive Heart FailureANTHONY MUSLIN; Fiscal Year: 2009..Our findings will help to identify specific signaling mechanisms involved in the regulation of cardiac myocyte growth and metabolism. ..
- FLUORESCENCE-ACTIVATED CELL SORTERChristian Schindler; Fiscal Year: 2004..abstract_text> ..
- Nuclear cofactors in Human Thyroid DiseaseRoy Weiss; Fiscal Year: 2007..3) Determine the cause for hypersensitivity to TH. This will allow clinicians to better identify factors influencing thyroid function. ..
- DOXYCYCLINE FOR BLEEDING IN PROGESTIN ONLY CONTRACEPTORSDavid Archer; Fiscal Year: 2006..If successful, DOX treatment could become an important adjuvant for treatment of this and possibly other inflammatory disorders effecting reproductive tract tissues. ..
- Regulation of Notch signaling by NKAPVIRGINIA SHAPIRO; Fiscal Year: 2008..This proposal will focus on understanding how NKAP, a negative regulator of Notch signaling, affects lymphocyte development, activation and effector function. [unreadable] [unreadable] [unreadable]..
- RGS PROTEIN FUNCTION IN CARDIAC PHYSIOLOGYANTHONY MUSLIN; Fiscal Year: 2008..These experiments will help define the role of RGS proteins in the pathogenesis of cardiac hypertrophy and contractile dysfunction and may provide important information for the development of novel therapeutic agents. ..