NEGR1

Summary

Gene Symbol: NEGR1
Description: neuronal growth regulator 1
Alias: DMML2433, IGLON4, KILON, Ntra, neuronal growth regulator 1, IgLON family member 4, a kindred of IgLON, neurotractin
Species: human

Top Publications

  1. doi Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    Gudmar Thorleifsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:18-24. 2009
  2. doi Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference
    Florianne Bauer
    Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands
    Am J Clin Nutr 90:951-9. 2009
  3. pmc Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    Cristen J Willer
    Genetic Investigation of ANthropometric Traits Consortium
    Nat Genet 41:25-34. 2009
  4. doi Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
    Shengxu Li
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Am J Clin Nutr 91:184-90. 2010
  5. ncbi Biochemical and ultrastructural analyses of IgLON cell adhesion molecules, Kilon and OBCAM in the rat brain
    S Miyata
    Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    Neuroscience 117:645-58. 2003
  6. pmc Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP
    A Marg
    Max Delbruck Center for Molecular Medicine, D 13092 Berlin, Germany
    J Cell Biol 145:865-76. 1999
  7. ncbi Purification of the alternative sigma factor, sigma 54, from Salmonella typhimurium and characterization of sigma 54-holoenzyme
    D Popham
    Department of Plant Pathology, University of California, Berkeley 94720
    J Biol Chem 266:19510-8. 1991
  8. pmc Identification of a gene linked to Rhizobium meliloti ntrA whose product is homologous to a family to ATP-binding proteins
    L M Albright
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    J Bacteriol 171:1932-41. 1989
  9. pmc Initial cloning and sequencing of hydHG, an operon homologous to ntrBC and regulating the labile hydrogenase activity in Escherichia coli K-12
    K Stoker
    Department of Microbiology, Vrije Universiteit, Amsterdam, The Netherlands
    J Bacteriol 171:4448-56. 1989
  10. pmc Tight linkage of glnA and a putative regulatory gene in Rhizobium leguminosarum
    S Colonna-Romano
    Nucleic Acids Res 15:1951-64. 1987

Research Grants

Scientific Experts

Detail Information

Publications120 found, 100 shown here

  1. doi Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    Gudmar Thorleifsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:18-24. 2009
    ..6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity...
  2. doi Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference
    Florianne Bauer
    Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands
    Am J Clin Nutr 90:951-9. 2009
    ..New genetic loci, most of which are expressed in the brain, have recently been reported to contribute to the development of obesity. The brain, especially the hypothalamus, is strongly involved in regulating weight and food intake...
  3. pmc Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    Cristen J Willer
    Genetic Investigation of ANthropometric Traits Consortium
    Nat Genet 41:25-34. 2009
    ..FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant)...
  4. doi Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
    Shengxu Li
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
    Am J Clin Nutr 91:184-90. 2010
    ..Large-scale genome-wide association studies have identified 12 genetic loci that are robustly associated with body mass index (BMI)...
  5. ncbi Biochemical and ultrastructural analyses of IgLON cell adhesion molecules, Kilon and OBCAM in the rat brain
    S Miyata
    Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    Neuroscience 117:645-58. 2003
    b>Kilon (kindred of IgLON) and opioid-binding cell adhesion molecule belong to the IgLON subgroup of immunoglobulin superfamily together with the limbic system-associated membrane protein and neurotrimin...
  6. pmc Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP
    A Marg
    Max Delbruck Center for Molecular Medicine, D 13092 Berlin, Germany
    J Cell Biol 145:865-76. 1999
    ..Using this approach, we identified a novel neural IgSF member, termed neurotractin. This GPI-linked cell surface glycoprotein is composed of three Ig-like domains and belongs to the IgLON ..
  7. ncbi Purification of the alternative sigma factor, sigma 54, from Salmonella typhimurium and characterization of sigma 54-holoenzyme
    D Popham
    Department of Plant Pathology, University of California, Berkeley 94720
    J Biol Chem 266:19510-8. 1991
    ..We have determined the complete nucleotide sequence of the gene encoding sigma 54 (ntrA) in Salmonella.
  8. pmc Identification of a gene linked to Rhizobium meliloti ntrA whose product is homologous to a family to ATP-binding proteins
    L M Albright
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    J Bacteriol 171:1932-41. 1989
    The ntrA gene of Rhizobium meliloti has recently been identified and shown to be required for a diverse set of metabolic functions (C. W. Ronson, B. T. Nixon, L. M. Albright, and F. M. Ausubel, J. Bacteriol. 169:2424-2431, 1987)...
  9. pmc Initial cloning and sequencing of hydHG, an operon homologous to ntrBC and regulating the labile hydrogenase activity in Escherichia coli K-12
    K Stoker
    Department of Microbiology, Vrije Universiteit, Amsterdam, The Netherlands
    J Bacteriol 171:4448-56. 1989
    ..This conclusion is in agreement with the results of Birkmann et al. (A. Birkmann, R. G. Sawers, and A. Böck, Mol. Gen. Genet. 210:535-542, 1987), who demonstrated ntrA dependence for the labile hydrogenase activity.
  10. pmc Tight linkage of glnA and a putative regulatory gene in Rhizobium leguminosarum
    S Colonna-Romano
    Nucleic Acids Res 15:1951-64. 1987
    ..Upstream of glnA we found an ORF of 111 codons (ORF111) preceded by the consensus sequence for an ntrA-dependent promoter...
  11. ncbi Nucleotide sequence of the regulatory gene xylR of the TOL plasmid from Pseudomonas putida
    S Inouye
    Department of Biochemistry, Yamaguchi University School of Medicine, Ube, Japan
    Gene 66:301-6. 1988
    ..aa 234-473) corresponds to the region that was proposed to interact with RNA polymerase having a sigma factor, NtrA [Drummond et al., EMBO J. 5 (1986) 441-447]...
  12. ncbi The xylS gene positive regulator of TOL plasmid pWWO: identification, sequence analysis and overproduction leading to constitutive expression of meta cleavage operon
    N Mermod
    Mol Gen Genet 207:349-54. 1987
    ..Interestingly, amino acid sequence homology was also found with sigma factors of E. coli (ntrA and htpR products) and Bacillus subtilis (spoIIG and phage SPOI Gp34 products) and other RNA polymerase core-..
  13. pmc Nitrogen regulatory locus "glnR" of enteric bacteria is composed of cistrons ntrB and ntrC: identification of their protein products
    N McFarland
    Proc Natl Acad Sci U S A 78:2135-9. 1981
    ..3.1.2]; mutations were selected as suppressors of glnF (which we propose to rename ntrA), a selection used previously to isolate glnR mutations...
  14. pmc Symbiotic nitrogen fixation by a nifA deletion mutant of Rhizobium meliloti: the role of an unusual ntrC allele
    M Labes
    McMaster University, Department of Biology, Hamilton, Ontario, Canada
    J Bacteriol 175:2662-73. 1993
    In the N2-fixing alfalfa symbiont Rhizobium meliloti, the three sigma 54 (NTRA)-dependent positively acting regulatory proteins NIFA, NTRC, and DCTD are required for activation of promoters involved in N2 fixation (pnifHDKE and pfixABCX), ..
  15. pmc Function of a principal Na(+)/H(+) antiporter, ShaA, is required for initiation of sporulation in Bacillus subtilis
    S Kosono
    Microbiology Laboratory, Institute of Physical and Chemical Research RIKEN, Wako, Saitama 351 0198, Japan
    J Bacteriol 182:898-904. 2000
    ShaA (sodium/hydrogen antiporter, previously termed YufT [or NtrA]), which is responsible for Na(+)/H(+) antiporter activity, is considered to be the major Na(+) excretion system in Bacillus subtilis...
  16. pmc Prediction and overview of the RpoN-regulon in closely related species of the Rhizobiales
    Bruno Dombrecht
    Centre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, 3001 Heverlee, Belgium
    Genome Biol 3:RESEARCH0076. 2002
    In the rhizobia, a group of symbiotic Gram-negative soil bacteria, RpoN (sigma54, sigmaN, NtrA) is best known as the sigma factor enabling transcription of the nitrogen fixation genes...
  17. pmc Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cells
    Tatiana Tondreau
    Institut Jules Bordet, Universite Libre de Bruxelles, Laboratory of Experimental Hematology, 121, Bd de Waterloo, 1000 Brussels, Belgium
    BMC Genomics 9:166. 2008
    ..Indeed, many studies have demonstrated that MSC can give rise to neuronal cells as well as many tissue-specific cell phenotypes...
  18. pmc Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis
    Ivonne Jarick
    Institute of Medical Biometry and Epidemiology, Philipps University of Marburg, Bunsenstraße 3, D 35037 Marburg, Germany
    Hum Mol Genet 20:840-52. 2011
    ..19; 95% confidence interval = 1.016-1.394). We also replicated two common deletions (near NEGR1 and at chromosome 10q11.22) that have previously been reported to be associated with body weight...
  19. doi Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma
    Junko Takita
    Department of Cell Therapy and Transplantation, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 102:1645-50. 2011
    MYEOV and NEGR1 are novel candidate gene targets in neuroblastoma that were identified by chromosomal gain in 11q13 and loss in 1p31, respectively, through single nucleotide polymorphism array analysis...
  20. pmc Susceptibility variants for obesity and colorectal cancer risk: the multiethnic cohort and PAGE studies
    Unhee Lim
    Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA
    Int J Cancer 131:E1038-43. 2012
    ..single nucleotide polymorphisms (SNPs) in 15 loci (BDNF, FAIM2, FTO, GNPDA2, KCTD15, LYPLAL1, MC4R, MSRA, MTCH2, NEGR1, NRXN3, SEC16B, SH2B1, TFAP2B and TMEM18) were genotyped in a case-control study of 2,033 colorectal cancer cases ..
  21. pmc Superparamagnetic iron oxide nanoparticles alter expression of obesity and T2D-associated risk genes in human adipocytes
    S Sharifi
    Department of Biomedical Engineering, W J Kolff Institute, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Sci Rep 3:2173. 2013
    ..mRNA of GULP1, SLC30A8, NEGR1, SEC16B, MTCH2, MAF, MC4R, and TMEM195 were severely induced, whereas INSIG2, NAMPT, MTMR9, PFKP, KCTD15, LPL and ..
  22. doi Psychiatric patient stratification using biosignatures based on cerebrospinal fluid protein expression clusters
    Giuseppina Maccarrone
    Max Planck Institute of Psychiatry, Kraepelinstr 2, D 80804 Munich, Germany
    J Psychiatr Res 47:1572-80. 2013
    ..At the same time several protein sets that play a role in neuronal growth, proliferation and differentiation (NEGR1, NPDC1), neurotransmission (SEZ6) and protection from oxidative damage (GPX3) were able to distinguish diseased ..
  23. ncbi Renal replacement therapy in acute poisonings--one center experience
    Miroslav Mydlik
    IVth Internal Clinic, University Hospital of L Pasteur and Medical School of P J Safárik University, Kosice, Slovak Republic
    Przegl Lek 70:381-5. 2013
    ..of patients with the kidney damage were presented from the diagnostic, differential diagnostic, conservative, ntra- and extracorporeal elimination treatment point of view...
  24. doi Redox signaling mediates the expression of a sulfate-deprivation-inducible microRNA395 in Arabidopsis
    Guru Jagadeeswaran
    Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK, 740748, USA
    Plant J 77:85-96. 2014
    ..in cad2 mutant (deficient in GSH biosynthesis) that is defective in glutaredoxin-dependent redox signaling and ntra/ntrb (defective in thioredoxin reductases a and b) double mutants that are defective in thioredoxin-dependent redox ..
  25. pmc The transcriptional regulators TAZ and YAP direct transforming growth factor β-induced tumorigenic phenotypes in breast cancer cells
    Samantha E Hiemer
    From the Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118
    J Biol Chem 289:13461-74. 2014
    ..Importantly, genes cooperatively regulated by TAZ/YAP, TEAD, and TGFβ, such as the novel targets NEGR1 and UCA1, are necessary for maintaining tumorigenic activity in metastatic breast cancer cells...
  26. doi NADPH-dependent thioredoxin reductase A (NTRA) confers elevated tolerance to oxidative stress and drought
    Joon Yung Cha
    Division of Applied Life Science BK21plus, PMBBRC and IALS, Gyeongsang National University, Jinju 660 701, Republic of Korea
    Plant Physiol Biochem 80:184-91. 2014
    ..Cytoplasmic NTRA, mitochondrial NTRB, and chloroplastic NTRC are the three conserved NTRs which cooperate with specific sub-..
  27. doi Common variants in BDNF, FAIM2, FTO, MC4R, NEGR1, and SH2B1 show association with obesity-related variables in Spanish Roma population
    Alaitz Poveda
    Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Science and Technology, University of the Basque Country UPV EHU, 48080, Bilbao, Spain
    Am J Hum Biol 26:660-9. 2014
    ..The objective of this study is to investigate the association between previously GWAS identified genetic variants predisposing to obesity in Europeans and obesity-related phenotypes in Roma population...
  28. pmc Expression profiling of RNA transcripts during neuronal maturation and ischemic injury
    Prameet Kaur
    Department of Biochemistry and Neuroscience Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    PLoS ONE 9:e103525. 2014
    ..Verification of expression of the Axin2, Prkcb, Cntn1, Ncam1, Negr1, Nrxn1 and Sh2b3 mRNAs and their respective long non-coding RNAs in an in vitro model of ischemic-reperfusion ..
  29. doi Impact of NEGR1 genetic variability on psychological traits of patients with eating disorders
    C Gamero-Villarroel
    Department of Medical and Surgical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain
    Pharmacogenomics J 15:278-83. 2015
    Genetics variants in the NEGR1 gene, strongly expressed in the brain, have been reported to affect the neuronal control of food intake therefore inducing obesity...
  30. doi Adult adiposity susceptibility loci, early growth and general and abdominal fatness in childhood: the Generation R Study
    S Vogelezang
    1 The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands 2 Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands 3 Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Int J Obes (Lond) 39:1001-9. 2015
    ..Genome-wide association studies in adults have identified genetic loci associated with adiposity measures. Little is known about the effects of these loci on growth and body fat distribution from early childhood onwards...
  31. pmc Thioredoxin, a master regulator of the tricarboxylic acid cycle in plant mitochondria
    Danilo M Daloso
    Max Planck Institut fur Molekulare Pflanzenphysiologie, 14476 Potsdam Golm, Germany Max Planck Partner Group at the Departamento de Biologia Vegetal, Universidade Federal de Vicosa, 36570 900 Viçosa, MG, Brazil
    Proc Natl Acad Sci U S A 112:E1392-400. 2015
    ..levels, mutants of the mitochondrial TRX pathway in Arabidopsis: the NADP-TRX reductase a and b double mutant (ntra ntrb) and the mitochondrially located thioredoxin o1 (trxo1) mutant...
  32. doi Clinical and Molecular Cytogenetic Characterization of a de novo Interstitial 1p31.1p31.3 Deletion in a Boy with Moderate Intellectual Disability and Severe Language Impairment
    Elisa Tassano
    Laboratorio di Citogenetica, Istituto G Gaslini, Genova, Italy
    Cytogenet Genome Res 146:39-43. 2015
    ..gene), LRRC7 (MIM 614453; leucine-rich repeat-containing protein 7), and NEGR1 (MIM 613173; neuronal growth regulator 1)...
  33. doi A long non-coding RNA, BC048612 and a microRNA, miR-203 coordinate the gene expression of neuronal growth regulator 1 (NEGR1) adhesion protein
    Prameet Kaur
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, 117597, Singapore
    Biochim Biophys Acta 1863:533-43. 2016
    ..b>Neuronal growth regulator 1 (NEGR1) is a cell adhesion molecule that has been shown to play an important role in neurite outgrowth ..
  34. pmc SRBreak: A Read-Depth and Split-Read Framework to Identify Breakpoints of Different Events Inside Simple Copy-Number Variable Regions
    Hoang T Nguyen
    Department of Biochemistry, University of OtagoDunedin, New Zealand Virtual Institute of Statistical GeneticsDunedin, New Zealand Department of Psychiatry, Mount Sinai School of Medicine, New YorkNY, USA Department of Mathematics, Cao Thang College of TechnologyHo Chi Minh City, Vietnam
    Front Genet 7:160. 2016
    ..When applied to three loci from existing human resequencing data sets (NEGR1, LCE3, IRGM) the pipeline obtained good concordance with results from the 1000 Genomes Project (92, 100, and 82%, ..
  35. ncbi Association between copy-number variation on metabolic phenotypes and HDL-C levels in patients with polycystic ovary syndrome
    Birgit Knebel
    Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich Heine University Düsseldorf, Leibniz Center for Diabetes Research, 40225, Dusseldorf, Germany
    Mol Biol Rep . 2016
    ..The intragenic rs1244979, rs2815752 in NEGR1 gene, and rs780094 in GCKR gene were genotyped and CNVs were determined by droplet digital polymerase chain ..
  36. pmc Promoter-Specific Expression and Genomic Structure of IgLON Family Genes in Mouse
    Taavi Vanaveski
    Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu Tartu, Estonia
    Front Neurosci 11:38. 2017
    IgLON family is composed of five genes: Lsamp, Ntm, Opcml, Negr1, and Iglon5; encoding for five highly homologous neural adhesion proteins that regulate neurite outgrowth and synapse formation...
  37. pmc Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course
    Mariaelisa Graff
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27517, USA
    Hum Mol Genet 22:3597-607. 2013
    ..05). These results suggest that genetic loci for BMI can vary in their effects across the life course, underlying the importance of evaluating BMI at different ages...
  38. doi NTR/NRX define a new thioredoxin system in the nucleus of Arabidopsis thaliana cells
    Corinne Marchal
    Université Perpignan Via Domitia, CNRS, Laboratoire Génome et Développement des Plantes, UMR 5096, 58 Avenue Paul Alduy Bat T, F 66860, Perpignan, France
    Mol Plant 7:30-44. 2014
    ..NRX1 and NRX2 have disulfide reduction capacities, although NRX1 alone can be reduced by the thioredoxin reductase NTRA. We also show that both NRX1 and NRX2 have a dual nuclear/cytosolic localization...
  39. pmc Transcription of glnA by purified Escherichia coli components: core RNA polymerase and the products of glnF, glnG, and glnL
    T P Hunt
    Proc Natl Acad Sci U S A 82:8453-7. 1985
    We have shown that the purified glnF (ntrA) product of Escherichia coli binds to core RNA polymerase. Together these proteins initiated transcription at the nitrogen-regulated promoter glnAp2 on a supercoiled template...
  40. pmc Products of nitrogen regulatory genes ntrA and ntrC of enteric bacteria activate glnA transcription in vitro: evidence that the ntrA product is a sigma factor
    J Hirschman
    Proc Natl Acad Sci U S A 82:7525-9. 1985
    In enteric bacteria the products of two nitrogen regulatory genes, ntrA and ntrC, activate transcription of glnA, the structural gene encoding glutamine synthetase, both in vivo and in vitro...
  41. pmc Rhizobium meliloti ntrA (rpoN) gene is required for diverse metabolic functions
    C W Ronson
    J Bacteriol 169:2424-31. 1987
    We report the identification and cloning of an ntrA-like (glnF rpoN) gene of Rhizobium meliloti and show that the R...
  42. ncbi Promotion of neuronal cell adhesion by members of the IgLON family occurs in the absence of either support or modification of neurite outgrowth
    Christine J McNamee
    Department of Human Anatomy and Cell Biology, The University of Liverpool, Liverpool, UK
    J Neurochem 80:941-8. 2002
    ..The family consists of LAMP, OBCAM, neurotrimin/CEPU-1 and neurotractin/kilon...
  43. ncbi Review of 61 cases of odontoma. Presentation of an erupted complex odontoma
    Susana Amado Cuesta
    Facultad de Odontologia, Universidad de Barcelona, Espana
    Med Oral 8:366-73. 2003
    ..We made the revision of the cases of diagnosed odontomas between 1983 and 2001 in the Clínica Ntra. Sra...
  44. ncbi The IgLON family in epithelial ovarian cancer: expression profiles and clinicopathologic correlates
    Evangelos Ntougkos
    Cancer Research UK Centre, University of Edinburgh, Edinburgh, United Kingdom
    Clin Cancer Res 11:5764-8. 2005
    The IgLON family of cell adhesion molecules, comprising OPCML, HNT, LSAMP, and NEGR1, has recently been linked to cancer, through two of its members being proposed as tumor suppressors...
  45. pmc Implication of European-derived adiposity loci in African Americans
    J M Hester
    Center for Diabetes Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Int J Obes (Lond) 36:465-73. 2012
    ..Limited study of these loci has been reported in African Americans. Here we examined the effects of these previously identified adiposity loci in African Americans...
  46. doi Overexpression of IgLON cell adhesion molecules changes proliferation and cell size of cortical astrocytes
    Chiaki Sugimoto
    Department of Applied Biology, Kyoto Institute of Technology, Kyoto, Japan
    Cell Biochem Funct 30:400-5. 2012
    ..of limbic system-associated protein (LAMP), opioid binding cell adhesion molecule (OBCAM), neurotrimin (Ntm) and Kilon. In the present study, we investigated the overexpression of LAMP, OBCAM, Ntm and Kilon on the proliferation and ..
  47. doi The role of obesity-related genetic loci in insulin sensitivity
    T Fall
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Diabet Med 29:e62-6. 2012
    ..There is a strong link between obesity and insulin sensitivity, and we hypothesized that known obesity susceptibility loci may act via effects on insulin sensitivity...
  48. doi What model organisms and interactomics can reveal about the genetics of human obesity
    Michael J Williams
    Department of Neuroscience, Functional Pharmacology, Biomedical Center, Uppsala University, Uppsala, Sweden
    Cell Mol Life Sci 69:3819-34. 2012
    ..biological databases and discovered 33 additional genes associated with human obesity (CADM2, GIPR, GPCR5B, LRP1B, NEGR1, NRXN3, SH2B1, FANCL, GNPDA2, HMGCR, MAP2K5, NUDT3, PRKD1, QPCTL, TNNI3K, MTCH2, DNAJC27, SLC39A8, MTIF3, RPL27A, ..
  49. doi Nutritional state affects the expression of the obesity-associated genes Etv5, Faim2, Fto, and Negr1
    Arjen J Boender
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Obesity (Silver Spring) 20:2420-5. 2012
    ..We show that the expression of Etv5, Faim2, Fto, Negr1 but not Sh2b1 is affected by nutritional state in these two areas, thereby providing insight into the relationship ..
  50. doi Functional relevance of genes implicated by obesity genome-wide association study signals for human adipocyte biology
    F Bernhard
    Center for Pediatric Research, Hospital for Children and Adolescents, Department of Women s and Child Health, University of Leipzig, Liebigstraße 21, Leipzig, Germany
    Diabetologia 56:311-22. 2013
    ..We investigated the functional relevance of such genes in human adipocytes...
  51. pmc The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study
    Mariaelisa Graff
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Diabetes 62:1763-7. 2013
    ..heterogeneity in the associations of five established obesity risk variants (near FTO, GNPDA2, MTCH2, TMEM18, and NEGR1) with BMI across four distinct epochs of adulthood: 1) young adulthood (ages 18-25 years), adulthood (ages 26-49 ..
  52. pmc Replication of established common genetic variants for adult BMI and childhood obesity in Greek adolescents: the TEENAGE study
    Ioanna Ntalla
    Harokopio University of Athens, Department of Nutrition and Dietetics, 17671 Athens, Greece
    Ann Hum Genet 77:268-74. 2013
    ..05). Variants at TFAP2B and NEGR1 loci showed nominal association (p < 0.05) with BMI and/or overweight risk in males and females respectively...
  53. pmc Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children
    Aurora Mejía-Benítez
    Departamento de Genetica y Biologia Molecular, Centro de Investigación yde Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico
    BMC Med Genet 14:21. 2013
    ..We aimed to assess the contribution of some of these SNPs to obesity risk and to the variation of related metabolic traits, in Mexican children...
  54. pmc Rs4074134 near BDNF gene is associated with type 2 diabetes mellitus in Chinese Han population independently of body mass index
    Xueyao Han
    Department of Endocrinology and Metabolism, Peking University People s Hospital, Peking University Diabetes Center, Beijing, China
    PLoS ONE 8:e56898. 2013
    ..Five genetic loci including rs2815752 near NEGR1, rs10938397 near GNPDA2, rs4074134 near BDNF, rs17782313 near MC4R and rs1084753 near KCTD15 were genotyped...
  55. doi Family-based genome-wide copy number scan identifies five new genes of dyslexia involved in dendritic spinal plasticity
    Avinash M Veerappa
    Genomics Laboratory, Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore, India
    J Hum Genet 58:539-47. 2013
    ..CNVs) in ten Indian dyslexic families revealed the presence of five de novo CNVs in regions harboring GABARAP, NEGR1, ACCN1, DCDC5, and one in already known candidate gene CNTNAP2...
  56. pmc Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study
    Sungshim Lani Park
    Epidemiology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA
    Am J Epidemiol 178:780-90. 2013
    ..We investigated the associations between 6 obesity risk variants in (or near) the NEGR1, TMEM18, BDNF, FTO, MC4R, and KCTD15 genes and macronutrient intake (carbohydrate, protein, ethanol, and fat) in 3 ..
  57. doi Functional analysis of seven genes linked to body mass index and adiposity by genome-wide association studies: a review
    John R Speakman
    Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, PR China Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK
    Hum Hered 75:57-79. 2013
    ..The remaining 7 SNPs are adjacent to, or within, the genes NEGR1, TMEM18, ETV5, FLJ35779, LINGO2, SH2B1 and GIPR, most of which are less well studied than FTO, particularly in the ..
  58. ncbi Activation of the Rhizobium leguminosarum glnII gene by NtrC is dependent on upstream DNA sequences
    E J Patriarca
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Mol Gen Genet 234:337-45. 1992
    ..transcribed as a monocistronic unit from a single promoter, which shows structural features characteristic of rpoN (ntrA)-dependent promoters. In K...
  59. ncbi Analysis of an upstream regulatory sequence required for activation of the regulatory gene xylS in xylene metabolism directed by the TOL plasmid of Pseudomonas putida
    M Gomada
    Department of Biochemistry, Yamaguchi University School of Medicine, Japan
    Mol Gen Genet 233:419-26. 1992
    ..by another positive regulator, XylR, in the presence of m-xylene and is dependent on RNA polymerase containing the NtrA protein (sigma 54)...
  60. ncbi Transcriptional regulation of cytochrome d in nitrogen-fixing Azotobacter vinelandii. Evidence that up-regulation during N2 fixation is independent of nifA but dependent on ntrA
    F Moshiri
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218
    J Biol Chem 266:23169-74. 1991
    ..5-fold upon the induction of nitrogen fixation. The cyd-lacZ fusions were characterized in a nifA- as well as an ntrA- background...
  61. ncbi Molecular characterization of an operon (hyp) necessary for the activity of the three hydrogenase isoenzymes in Escherichia coli
    S Lutz
    Lehrstuhl fur Mikrobiologie, Universitat Munchen, FRG
    Mol Microbiol 5:123-35. 1991
    ..chemical or proteolytic subunits, Under fermentative growth conditions, operon expression was governed by an NtrA-dependent promoter lying upstream of hypA working together with an fnr gene product-dependent promoter which was ..
  62. ncbi Cloning, sequencing and expression of the glutamine synthetase structural gene (glnA) from the obligate methanotroph Methylococcus capsulatus (Bath)
    D L Cardy
    Department of Biological Sciences, University of Warwick, Coventry, UK
    J Gen Microbiol 136:343-52. 1990
    ..coli-type promoter. Promoter P2, which was located between P1 and P3, resembled the NtrA-dependent promoters of enteric organisms...
  63. pmc Bradyrhizobium japonicum has two differentially regulated, functional homologs of the sigma 54 gene (rpoN)
    I Kullik
    Mikrobiologisches Institut, Eidgenossische Technische Hochschule, ETH Zentrum, Zurich, Switzerland
    J Bacteriol 173:1125-38. 1991
    Recognition of -24/-12-type promoters by RNA polymerase requires a special sigma factor, sigma 54 (RpoN NtrA GlnF)...
  64. ncbi Analysis of the C4-dicarboxylate transport genes of Rhizobium meliloti: nucleotide sequence and deduced products of dctA, dctB, and dctD
    R J Watson
    Plant Research Centre, Agriculture Canada, Ottawa, Ontario
    Mol Plant Microbe Interact 3:174-81. 1990
    ..The dctA gene is preceded by the sequence CTGGCACG-N4-TTGCT, which is characteristic of promoters requiring the ntrA-encoded protein for activation...
  65. ncbi Characterization of divergent NtrA-dependent promoters in the anaerobically expressed gene cluster coding for hydrogenase 3 components of Escherichia coli
    S Lutz
    Lehrstuhl fur Mikrobiologie, Universitat Munchen, FRG
    Mol Microbiol 4:13-20. 1990
    ..analysis revealed the existence of a 210 bp non-coding region containing two sequences showing homology to -24/-12 NtrA-dependent promoters...
  66. ncbi Cloning and sequence analysis of the ntrA (rpoN) gene of Pseudomonas putida
    S Inouye
    Department of Biochemistry, Yamaguchi University School of Medicine, Ube, Japan
    Gene 85:145-52. 1989
    The gene encoding a sigma factor NtrA (RpoN) was cloned from Pseudomonas putida by cross-hybridization with a probe containing a part of the corresponding Escherichia coli gene. The cloned gene complemented an ntrA mutation of E...
  67. pmc Protein kinase and phosphoprotein phosphatase activities of nitrogen regulatory proteins NTRB and NTRC of enteric bacteria: roles of the conserved amino-terminal domain of NTRC
    J Keener
    Department of Microbiology and Immunology, University of California, Berkeley 94720
    Proc Natl Acad Sci U S A 85:4976-80. 1988
    ..activates transcription of nitrogen-regulated genes by a holoenzyme form of RNA polymerase that contains the ntrA product (sigma 54) as sigma factor...
  68. pmc Deduced products of C4-dicarboxylate transport regulatory genes of Rhizobium leguminosarum are homologous to nitrogen regulatory gene products
    C W Ronson
    Grasslands Division, Department of Scientific and Industrial Research, Palmerston North, New Zealand
    Nucleic Acids Res 15:7921-34. 1987
    ..with the products of ntrC and nifA, transcriptional activators that require the alternate sigma factor rpoN (ntrA) as co-activator. The central region of DctD also contained a potential ATP-binding domain...
  69. ncbi Molecular cloning and characterization of a proline iminopeptidase gene from Neisseria gonorrhoeae
    N H Albertson
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor 48109 0620
    Mol Microbiol 9:1203-11. 1993
    ..coli, determined by primer extension analysis, was characteristic of an NtrA or sigma-54-dependent promotor. Complementation of an E...
  70. ncbi Cloning and sequence of the Rhizobium leguminosarum biovar phaseoli fixA gene
    J Michiels
    F A Janssens Laboratory of Genetics, Catholic University of Leuven, Heverlee, Belgium
    Biochim Biophys Acta 1144:232-3. 1993
    ..The corresponding gene product is highly homologous to the Rhizobium meliloti and Azorhizobium caulinodans FixA proteins. Putative NtrA- and NifA-binding sites are identified in the fixA promoter region.
  71. ncbi Azorhizobium caulinodans nitrogen fixation (nif/fix) gene regulation: mutagenesis of the nifA -24/-12 promoter element, characterization of a ntrA(rpoN) gene, and derivation of a model
    J Stigter
    MSU DOE Plant Research Laboratory, East Lansing 48824
    Mol Plant Microbe Interact 6:238-52. 1993
    ..the -24/-12 promoter element is important for nifA gene expression and suggesting the involvement of a sigma 54 (NtrA/RpoN)-type transcription factor in nifA gene regulation...
  72. pmc Simultaneous prevention of glutamine synthesis and high-affinity transport attenuates Salmonella typhimurium virulence
    K E Klose
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 65:587-96. 1997
    ..is under the control of the nitrogen-regulatory (ntr) system comprising the alternate sigma factor sigma54 (NtrA) and the two-component sensor-transcriptional activator pair NtrB and NtrC...
  73. ncbi Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family
    N Funatsu
    Department of Biotechnology, Kyoto Institute of Technology, Kyoto 606 8585, Japan
    J Biol Chem 274:8224-30. 1999
    ..family members including LAMP, OBCAM, neurotrimin, CEPU-1, AvGP50, and GP55, we termed this protein Kilon (a kindred of IgLON)...
  74. pmc prpR, ntrA, and ihf functions are required for expression of the prpBCDE operon, encoding enzymes that catabolize propionate in Salmonella enterica serovar typhimurium LT2
    S Palacios
    Department of Bacteriology, University of Wisconsin Madison, 53706 1567, USA
    J Bacteriol 182:905-10. 2000
    ..Transcription of the lacZ reporter in prpR, ntrA, and ihfB mutants was 85-, 83-, and 15-fold lower than the level of transcription measured in strains carrying the ..
  75. pmc Virulence of the phytopathogen Pseudomonas syringae pv. maculicola is rpoN dependent
    E L Hendrickson
    Department of Genetics, Harvard Medical School, Bosston, Massachusetts 02114, USA
    J Bacteriol 182:3498-507. 2000
    We cloned the rpoN (ntrA and glnF) gene encoding sigma(54) from the phytopathogen Pseudomonas syringae pv. maculicola strain ES4326. The P...
  76. ncbi Expression of the IgLON cell adhesion molecules Kilon and OBCAM in hypothalamic magnocellular neurons
    S Miyata
    Department of Applied Biology, Kyoto Institute of Technology, Kyoto 606 8585, Japan
    J Comp Neurol 424:74-85. 2000
    ..In the present study, we investigated the expression of two immunoglobulin superfamily (IgSF) proteins, Kilon and OBCAM, in the magnocellular neurons by using monoclonal antibodies...
  77. ncbi [Characteristics of genes identified in the 120 MDa plasmid DNA in a mutant of Azospirillum brasilense Sp245 bacteria, defective in polar flagellation and swarming]
    E I Katsy
    Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Saratov, 410015 Russia
    Genetika 38:22-32. 2002
    ..The NtrA (sigma 54) boxes were found in their upstream regions. The products of orf1 and orf2 are 16.5 and 15...
  78. ncbi [Guillain-Barré syndrome in the northern area of Gran Canaria and the island of Lanzarote]
    Y Aladro-Benito
    Servicio de Neurologia, Hospital Universitario Dr Negrin, Las Palmas de Gran Canaria, Espana
    Rev Neurol 35:705-10. 2002
    ..The objective of this study is to analyse the incidence and clinical characteristics of Guillain Barre syndrome (GBS) in the Canary Islands...
  79. ncbi Dendrite-associated opioid-binding cell adhesion molecule localizes at neurosecretory granules in the hypothalamic magnocellular neurons
    S Miyata
    Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    Neuroscience 122:169-81. 2003
    ..b>Kilon, another IgLON member, was also shown to localize at the neurosecretory granules of vasopressin-positive dendrites ..
  80. ncbi Gaze-dependent and time-restricted visual acuity measures in patients with Infantile Nystagmus Syndrome (INS)
    Dongsheng Yang
    Department of Ophthalmology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Ophthalmol 139:716-8. 2005
    ..We report a new method of measuring visual function in patients with INS by demonstrating the effects of eccentric gaze and forced time restriction on optotype recognition...
  81. ncbi Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion
    Michael Schafer
    Max Delbrueck Centre for Molecular Medicine, Developmental Neurobiology Group, D 13092 Berlin, Germany
    Mol Cell Neurosci 29:580-90. 2005
    ..Here, we cloned and characterized the murine IgLON subgroup member neurotractin/kilon, in the context of brain development and axonal regeneration...
  82. ncbi Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment
    Felix Elortza
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    J Proteome Res 5:935-43. 2006
    ....
  83. ncbi Unique properties of NADP-thioredoxin reductase C in legumes
    Fatima Alkhalfioui
    Physiologie Moléculaire des Semences, UMR 1191 Université d Angers Institut National d Horticulture INRA, ARES, 16 boulevard Lavoisier, 49045 Angers cedex 01, France
    J Exp Bot 58:969-78. 2007
    ..Beside NTRA and NTRB targeted to both cytosol and mitochondria of plant cells, there is in chloroplasts an unusual NTR (NTRC) ..
  84. pmc Inactivation of thioredoxin reductases reveals a complex interplay between thioredoxin and glutathione pathways in Arabidopsis development
    Jean Philippe Reichheld
    Laboratoire Génome et Développement des Plantes, Universite de Perpignan, Unite Mixte de Recherche, Centre National de la Recherche Scientifique 5096, Perpignan, France
    Plant Cell 19:1851-65. 2007
    ..The Arabidopsis thaliana genome has two genes coding for NTRs (NTRA and NTRB), both of which encode mitochondrial and cytosolic isoforms...
  85. pmc Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study
    Qiong Yang
    The National Heart, Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S12. 2007
    ..We sought to confirm known putative loci and identify novel loci that may influence either trait in genome-wide association and linkage analyses using the Affymetrix GeneChip 100K single nucleotide polymorphism (SNP) set...
  86. ncbi Sigma factors in Pseudomonas aeruginosa
    Eric Potvin
    Centre de Recherche sur la Fonction, Structure et Ingénierie des Protéines, Faculte de Medecine, Pavillon Charles Eugène Marchand, Universite Laval, Sainte Foy, Quebec, Canada
    FEMS Microbiol Rev 32:38-55. 2008
    ..and ECF including rpoD (sigma(70)), RpoH (sigma(32)), RpoF (FliA or sigma(28)), RpoS (sigma(S) or sigma(38)), RpoN (NtrA, sigma(54) or sigma(N)), ECF including AlgU (RpoE or sigma(22)), PvdS, SigX and a collection of uncharacterized ..
  87. ncbi [Hemoglobinopathies diagnosed at the University Hospital Ntra. Sra. de Candelaria and its area of reference in Santa Cruz de Tenerife during one year]
    S de las Heras Flórez
    Servicio de Analisis Clinicos, Hospital Universitario Nuestra Senora de Candelaria, Santa Cruz de Tenerife
    An Med Interna 25:61-6. 2008
    ..To describe number and type of hemoglobinopathies diagnosed in our area of reference during one year as well as the origin of these patients, to have a first contact with this pathology not characterized in our province until now...
  88. doi IgLON cell adhesion molecule Kilon is a crucial modulator for synapse number in hippocampal neurons
    Takashi Hashimoto
    Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    Brain Res 1224:1-11. 2008
    b>Kilon is a member of the IgLON family belonging to the immunoglobulin superfamily of cell adhesion molecules...
  89. doi Glycosylation analysis of IgLON family proteins in rat brain by liquid chromatography and multiple-stage mass spectrometry
    Satsuki Itoh
    Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Biochemistry 47:10132-54. 2008
    ..limbic-associated membrane protein (LAMP), opioid-binding cell adhesion molecule (OBCAM), neurotrimin, and Kilon, are immunoglobulin (Ig) superfamily cell adhesion molecules...
  90. doi Characterization of Brucella abortus sigma factor sigma54 (rpoN): genetic complementation of Sinorhizobium meliloti ntrA mutant
    Florencia Iannino
    Instituto de Investigaciones Biotecnologicas Instituto Tecnologico de Chascomus IIB INTECH, Consejo de Investigaciones Cientificas y Tecnicas, Universidad Nacional de General San Martín CONICET UNSAM, Av Gral Paz 5445, Buenos Aires, Argentina
    Microb Pathog 45:394-402. 2008
    ..pathogen Brucella abortus has an alternative sigma factor sigma54 (RpoN) highly similar to Sinorhizobium meliloti NtrA. RpoN was described to be required for the transcription of a wide range of genes involved in diverse physiological ..
  91. pmc A mutant GlnD nitrogen sensor protein leads to a nitrogen-fixing but ineffective Sinorhizobium meliloti symbiosis with alfalfa
    Svetlana N Yurgel
    Institute of Biological Chemistry and School of Molecular Biosciences, Washington State University, Pullman, WA 99164 6340, USA
    Proc Natl Acad Sci U S A 105:18958-63. 2008
    ..meliloti strains with mutations in genes related to nitrogen stress response regulation (glnD, glnB, ntrC, and ntrA) showed that catabolism of various nitrogen-containing compounds depended on the NtrC and GlnD components of the ..
  92. pmc A novel nitroreductase of Staphylococcus aureus with S-nitrosoglutathione reductase activity
    Ana Filipa N Tavares
    Instituto de Tecnologia Quimica e Biologica, UNL, Av da Republica EAN, 2780 157 Oeiras, Portugal
    J Bacteriol 191:3403-6. 2009
    In this report we show that inactivation of the putative nitroreductase SA0UHSC_00833 (ntrA) increases the sensitivity of Staphylococcus aureus to S-nitrosoglutathione (GSNO) and augments its resistance to nitrofurans. S...
  93. pmc The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI
    Jianhua Zhao
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 17:2254-7. 2009
    ..significant association to BMI, representing nine different loci including INSIG2, FTO, MC4R, TMEM18, GNPDA2, NEGR1, BDNF, KCTD15, and 1q25. Other loci revealed no evidence for association, namely at MTCH2, SH2B1, 12q13, and 3q27...
  94. doi IgLON cell adhesion molecules regulate synaptogenesis in hippocampal neurons
    Takashi Hashimoto
    Department of Applied Biology, Kyoto Institute of Technology, Sakyo ku, Kyoto, Japan
    Cell Biochem Funct 27:496-8. 2009
    ..molecules (CAMs) belonging to the immunoglobulin superfamily comprise of LAMP, neurotrimin (Ntm), OBCAM, and Kilon. In the present study, we performed the single and double transfection of IgLON gene constructs into hippocampal ..
  95. doi Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?
    Marek K Brandys
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 153:695-9. 2010
    ..The percentages of BMI-increasing alleles were equal between cases and controls. This study found no evidence that genetic variants regulating BMI in the general population are significantly associated with susceptibility to AN...
  96. doi Accumulation of flavonoids in an ntra ntrb mutant leads to tolerance to UV-C
    Talaat Bashandy
    Laboratoire Génome et Développement des Plantes, Universite de Perpignan, UMR CNRS 5096, 52 Avenue Paul Alduy, 66860 Perpignan, France
    Mol Plant 2:249-58. 2009
    ..There are two genes encoding NTRs (NTRA and NTRB) in the Arabidopsis genome, each encoding a cytosolic and a mitochondrial isoform...
  97. doi Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population
    Kikuko Hotta
    Laboratory for Endocrinology and Metabolism, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    J Hum Genet 54:727-31. 2009
    ..phenotype in the Caucasian populations is associated with variations in several genes, including neuronal growth regulator 1 (NEGR1), SEC16 homolog B (SCE16B), transmembrane protein 18 (TMEM18), ets variant 5 (ETV5), glucosamine-..
  98. doi Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study
    Axel Haupt
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Obesity (Silver Spring) 18:1212-7. 2010
    ..SNPs) TMEM18 rs6548238, KCTD15 rs11084753, GNPDA2 rs10938397, SH2B1 rs7498665, MTCH2 rs10838738, and NEGR1 rs2815752. We assessed BMI, waist circumference, total body fat, and lean body mass (bioimpedance)...
  99. doi Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population
    Chloe Y Y Cheung
    Department of Medicine, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    J Clin Endocrinol Metab 95:1395-403. 2010
    ..Recent large-scale genome-wide association studies identified novel genetic variants associated with obesity and body mass index (BMI) in addition to the well-described FTO and MC4R genetic variants...
  100. pmc Interplay between the NADP-linked thioredoxin and glutathione systems in Arabidopsis auxin signaling
    Talaat Bashandy
    Laboratoire Génome et Développement des Plantes, Universite de Perpignan, Unite Mixte de Recherche, Centre National de la Recherche Scientifique, Institut de Recherche pour le Développement Université de Perpignan Via Domitia 5096, 66860 Perpignan, France
    Plant Cell 22:376-91. 2010
    ..Here, we show by associating TRX reductases (ntra ntrb) and glutathione biosynthesis (cad2) mutations that these two thiol reduction pathways interfere with ..
  101. doi Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese
    Maggie C Y Ng
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China
    J Clin Endocrinol Metab 95:2418-25. 2010
    ..Recent genome-wide association studies have identified multiple novel loci associated with obesity in Europeans. We hypothesized that these genetic variants may be associated with obesity and type 2 diabetes (T2D) in Chinese...

Research Grants3

  1. Generation of antigen-specific regulation T cells
    Harald von Boehmer; Fiscal Year: 2012
    ..seen considerable progress in understanding the role of antigen-specific receptors on Treg that are involved in ntra- and extra-thymic generation of Treg and their recruitment to specific sites of antigen deposition...
  2. TRANSCRIPTIONAL REGULATION IN RHODOBACTER CAPSULATUS
    ROBERT KRANZ; Fiscal Year: 1992
    ..Specific aims include: sequencing and mutagenesis of an ntrA-like gene which codes for a RNA polymerase sigma factor used for nitrogen regulated promoters...
  3. Short-Latency Disparity Vergence in Strabismic Subjects
    Dongsheng Yang; Fiscal Year: 2006
    ..The rapid, reflex-like nature allows objective assessments of binocular function for potentially all age subjects since active visual attention is not required and promises for future studying of the development of binocular vision. ..