NDST3

Summary

Gene Symbol: NDST3
Description: N-deacetylase and N-sulfotransferase 3
Alias: HSST3, bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3, GlcNAc N-deacetylase/ N-sulfotransferase 3, N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3, N-deacetylase/N-sulfotransferase 3, N-heparan sulfate sulfotransferase 3, glucosaminyl N-deacetylase/N-sulfotransferase 3
Species: human

Top Publications

  1. ncbi Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family
    J Aikawa
    Division of Cellular and Molecular Medicine, Glycobiology Program, University of California, San Diego, La Jolla, California 92093 0687, USA
    J Biol Chem 274:2690-5. 1999
  2. ncbi Evaluation of European Schizophrenia GWAS Loci in Asian Populations via Comprehensive Meta-Analyses
    Xiao Xiao
    Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China
    Mol Neurobiol . 2016
  3. pmc A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese
    C Zhang
    Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Transl Psychiatry 6:e701. 2016
  4. pmc The NDST gene family in zebrafish: role of NDST1B in pharyngeal arch formation
    Beata Filipek-Gorniok
    Dept of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, PO Box 582, SE 751 23, Uppsala, Sweden
    PLoS ONE 10:e0119040. 2015
  5. doi rs11098403 polymorphism near NDST3 is associated with a reduced risk of schizophrenia in a Han Chinese population
    Li ze Gu
    Department of Laboratory Medicine, Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, China
    Neurosci Lett 581:42-5. 2014
  6. doi [111In-DOTA]LTT-SS28, a first pansomatostatin radioligand for in vivo targeting of somatostatin receptor-positive tumors
    Theodosia Maina
    Molecular Radiopharmacy, INRASTES, National Center for Scientific Research Demokritos, GR 153 10 Athens, Greece
    J Med Chem 57:6564-71. 2014
  7. doi Axenfeld-Rieger syndrome: further clinical and array delineation of four unrelated patients with a 4q25 microdeletion
    Hannah Titheradge
    Department of Clinical Genetics, Birmingham Women s NHS Foundation Trust, Birmingham, United Kingdom
    Am J Med Genet A 164:1695-701. 2014
  8. doi Simultaneous ultra-high performance liquid chromathograpy-electrospray ionization-quadrupole-time of flight mass spectrometry quantification of endogenous anandamide and related N-acylethanolamides in bio-matrices
    Roberta Ottria
    Dipartimento di Scienze Biomediche e Cliniche L Sacco, Universita degli Studi di Milano, Via G B Grassi, 74 20157 Milano, Italy Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 958:83-9. 2014
  9. ncbi Fish somatostatin sst3 receptor: comparison of radioligand and GTPgammaS binding, adenylate cyclase and phospholipase C activities reveals different agonist-dependent pharmacological signatures
    S Siehler
    Discovery Technologies, Novartis Institutes for BioMedical Research, WSJ 386 745, Novartis Pharma AG, CH 4002 Basel, Switzerland
    Auton Autacoid Pharmacol 25:1-16. 2005
  10. pmc Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder
    Todd Lencz
    1 Division of Research, Department of Psychiatry, The Zucker Hillside Hospital Division of the North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA 2 Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA 3 Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA 4 Department of Psychiatry, Hofstra University School of Medicine, Hempstead, New York 11550, USA 5 Department of Molecular Medicine, Hofstra University School of Medicine, Hempstead, New York 11550, USA 6
    Nat Commun 4:2739. 2013

Research Grants

  1. Lianchun Wang; Fiscal Year: 2016
  2. SYNTHESIS AND CONFORMATION OF PEPTIDE HORMONES
    Murray Goodman; Fiscal Year: 2003

Scientific Experts

  • Roberta Ottria
  • Zhihua Jiang
  • Hans Jurgen Wester
  • Kay Grobe
  • C Moinet
  • Yan Xue
  • Murray Goodman
  • Lianchun Wang
  • Xiao Xiao
  • C Zhang
  • Beata Filipek-Gorniok
  • Theodosia Maina
  • Li ze Gu
  • Hannah Titheradge
  • Todd Lencz
  • Haya H Al-Balool
  • Jean Claude Reubi
  • J Aikawa
  • Zhonghua Hu
  • Nadiya M Teplyuk
  • Srinivas R Pallerla
  • Evelyn C Krenn
  • P Antunes
  • Patricia Antunes
  • Anat Ben-Shlomo
  • S Siehler
  • Xiong Jian Luo
  • Zichao Liu
  • Ming Li
  • Y Fang
  • Z Wang
  • J Ni
  • W Lu
  • J Zhang
  • W Tang
  • Hong Chang
  • Lena Kjellen
  • Johan Ledin
  • Judith Habicher
  • Pernilla Carlsson
  • Tatjana Haitina
  • Yue Chun Zhang
  • Berthold A Nock
  • Fiona Togneri
  • Wei Ming Ling
  • Aikaterini Tatsi
  • Dominic McMullan
  • Marion de Jong
  • Denise Williams
  • Zao huo Cheng
  • Eric P Krenning
  • Renzo Cescato
  • Teng Jiang
  • Derek Lim
  • Zhen He Zhou
  • Aikaterini Kaloudi
  • Min Chi Chen
  • Meng Meng Ou
  • Louise Brueton
  • Beatrice Waser
  • Anil K Malhotra
  • Nakao Iwata
  • Chunyu Liu
  • A T A Cheng
  • Qiaoping Yuan
  • Judith A Badner
  • Colin Hodgkinson
  • Semanti Mukherjee
  • Sven Cichon
  • Majnu John
  • Markus M Nothen
  • John M Kane
  • Marcella Rietschel
  • Annette T Lee
  • Pamela DeRosse
  • Anne Pisanté
  • Jeffrey Rosenfeld
  • David Goldman
  • Saurav Guha
  • Chunling Zhang
  • Lijun Cheng
  • Peter K Gregersen
  • Ariel Darvasi
  • Masashi Ikeda
  • Itsik Pe'er
  • Julie Irving
  • William Rowe
  • Jake Clayton
  • Michael S Jackson
  • Pitsien Lang Ping Nam

Detail Information

Publications26

  1. ncbi Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family
    J Aikawa
    Division of Cellular and Molecular Medicine, Glycobiology Program, University of California, San Diego, La Jolla, California 92093 0687, USA
    J Biol Chem 274:2690-5. 1999
    ..We now report the identification of a third member of the NDST family, designated NDST3. A full-length cDNA clone (3...
  2. ncbi Evaluation of European Schizophrenia GWAS Loci in Asian Populations via Comprehensive Meta-Analyses
    Xiao Xiao
    Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China
    Mol Neurobiol . 2016
    ..Among the 19 GWAS loci, we replicated the risk associations of nine markers (e.g., SNPs at VRK2, ITIH3/4, NDST3, NOTCH4) surpassing significance level (two-tailed P < 0...
  3. pmc A comprehensive analysis of NDST3 for schizophrenia and bipolar disorder in Han Chinese
    C Zhang
    Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Transl Psychiatry 6:e701. 2016
    ..is located in the vicinity of the gene encoding N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3, (NDST3). This study aimed to replicate the results in a Han Chinese population and then potentially extend these findings...
  4. pmc The NDST gene family in zebrafish: role of NDST1B in pharyngeal arch formation
    Beata Filipek-Gorniok
    Dept of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Husargatan 3, PO Box 582, SE 751 23, Uppsala, Sweden
    PLoS ONE 10:e0119040. 2015
    ..Interestingly, the single zebrafish orthologue ndst3, is equally similar to tetrapod Ndst3 and Ndst4...
  5. doi rs11098403 polymorphism near NDST3 is associated with a reduced risk of schizophrenia in a Han Chinese population
    Li ze Gu
    Department of Laboratory Medicine, Wuxi Mental Health Center Affiliated to Nanjing Medical University, Wuxi, China
    Neurosci Lett 581:42-5. 2014
    ..genome-wide association study indicated that rs11098403, a single nucleotide polymorphism in the vicinity of NDST3, was strongly associated with the risk of schizophrenia in Caucasians...
  6. doi [111In-DOTA]LTT-SS28, a first pansomatostatin radioligand for in vivo targeting of somatostatin receptor-positive tumors
    Theodosia Maina
    Molecular Radiopharmacy, INRASTES, National Center for Scientific Research Demokritos, GR 153 10 Athens, Greece
    J Med Chem 57:6564-71. 2014
    ..Furthermore, [DOTA]LTT-SS28 behaved as an agonist at hsst2, hsst3, and hsst5, efficiently stimulating internalization of the three receptor subtypes...
  7. doi Axenfeld-Rieger syndrome: further clinical and array delineation of four unrelated patients with a 4q25 microdeletion
    Hannah Titheradge
    Department of Clinical Genetics, Birmingham Women s NHS Foundation Trust, Birmingham, United Kingdom
    Am J Med Genet A 164:1695-701. 2014
    ..We implicate the adjacent neuronally expressed genes; NEUROG2, UGT8, NDST3, and PRSS12 as potentially causal...
  8. doi Simultaneous ultra-high performance liquid chromathograpy-electrospray ionization-quadrupole-time of flight mass spectrometry quantification of endogenous anandamide and related N-acylethanolamides in bio-matrices
    Roberta Ottria
    Dipartimento di Scienze Biomediche e Cliniche L Sacco, Universita degli Studi di Milano, Via G B Grassi, 74 20157 Milano, Italy Electronic address
    J Chromatogr B Analyt Technol Biomed Life Sci 958:83-9. 2014
    ..Separation was performed on a Waters Acquity UPLC HSST3 column using a 9min elution gradient coupled with high resolution mass spectrometry (QTOF/MS)...
  9. ncbi Fish somatostatin sst3 receptor: comparison of radioligand and GTPgammaS binding, adenylate cyclase and phospholipase C activities reveals different agonist-dependent pharmacological signatures
    S Siehler
    Discovery Technologies, Novartis Institutes for BioMedical Research, WSJ 386 745, Novartis Pharma AG, CH 4002 Basel, Switzerland
    Auton Autacoid Pharmacol 25:1-16. 2005
    ..radioligand binding and/or second messenger features determined for fsst3 and/or human SRIF receptors (hsst2, hsst3 and hsst5)...
  10. pmc Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder
    Todd Lencz
    1 Division of Research, Department of Psychiatry, The Zucker Hillside Hospital Division of the North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA 2 Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA 3 Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA 4 Department of Psychiatry, Hofstra University School of Medicine, Hempstead, New York 11550, USA 5 Department of Molecular Medicine, Hofstra University School of Medicine, Hempstead, New York 11550, USA 6
    Nat Commun 4:2739. 2013
    ..In addition, this intergenic SNP significantly predicts postmortem cerebellar gene expression of NDST3, which encodes an enzyme critical to heparan sulphate metabolism...
  11. pmc Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant
    Haya H Al-Balool
    Institute of Genetic Medicine, Newcastle University, Newcastle NE1 3BZ, United Kingdom
    Genome Res 21:1788-99. 2011
    ..This is the first systematic experimental analysis of PTES in human, and it suggests both that the phenomenon is much more widespread than previously thought and that some PTES transcripts could be functional...
  12. ncbi Influence of different spacers on the biological profile of a DOTA-somatostatin analogue
    Patricia Antunes
    Division of Radiological Chemistry, Department of Radiology, University Hospital Basel, Switzerland
    Bioconjug Chem 18:84-92. 2007
    ..InIII-DOTA]-NOC for human sst2 (hsst2) was preserved with the structural modifications, while an overall drop for hsst3 affinity was observed, except in the case of [InIII-DOTA]-beta-Ala-NOC...
  13. ncbi Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4
    J Aikawa
    Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, California 92093 0687, USA
    J Biol Chem 276:5876-82. 2001
    ..The deduced amino acid sequence of NDST4 showed high sequence identity to NDST1, NDST2, and NDST3 in both species. NDST4 maps to human chromosome 4q25-26, very close to NDST3, located at 4q26-27...
  14. ncbi Novel non-peptide ligands for the somatostatin sst3 receptor
    C Moinet
    Institut Henri Beaufour, Les Ulis, France
    Bioorg Med Chem Lett 11:991-5. 2001
    ..Several compounds showed high affinity (Ki in 10(-6)-10(-8) M range) and selectivity at recombinant human somatostatin receptor subtype 3 (hsst3).
  15. ncbi Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites
    Kay Grobe
    Department of Cellular and Molecular Medicine, Glycobiology Training and Research Center, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0687, USA
    J Biol Chem 277:30699-706. 2002
    ..Because several growth factors and morphogens that bind heparan sulfate also contain structured 5'-UTRs, translational regulation may coordinate the action of these factors and their heparan sulfate co-receptors...
  16. ncbi Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes
    Kay Grobe
    Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California, San Diego, La Jolla, CA 92093 0687, USA
    Biochim Biophys Acta 1573:209-15. 2002
    ..Here, we review the role of the four vertebrate NDSTs in HS biosynthesis as well as their regulated expression. The main emphasis is the phenotypes of mice lacking one or more of the NDSTs...
  17. ncbi PET imaging of somatostatin receptors: design, synthesis and preclinical evaluation of a novel 18F-labelled, carbohydrated analogue of octreotide
    H J Wester
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munchen, Germany
    Eur J Nucl Med Mol Imaging 30:117-22. 2003
    ..19)F]FP-Gluc-TOCA showed no affinity to hsst1 and hsst3, moderate affinity to hsst4 (IC(50): 437+/-84 n M) and hsst5 (IC(50): 123+/-8...
  18. pmc The heparan and heparin metabolism pathway is involved in regulation of fatty acid composition
    Zhihua Jiang
    Department of Animal Sciences, Washington State University, Pullman, WA 99164 6351, USA
    Int J Biol Sci 7:659-63. 2011
    ..1), HS6ST1 (heparan sulfate 6-O-sulfotransferase 1), HS6ST3 (heparan sulfate 6-O-sulfotransferase 3), NDST3 (N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3), and SULT1A1 (sulfotransferase family, cytosolic, 1A, ..
  19. doi NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development
    Zhonghua Hu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 200031 Shanghai, China
    J Cell Sci 122:1145-54. 2009
    ..Here, we report that in spite of the redundant expression of Ndst2, Ndst3 and Ndst4 genes, Ndst1(-/-) mice display defective differentiation of lung cells and increased cell proliferation...
  20. pmc The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts
    Nadiya M Teplyuk
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655 0105, USA
    J Cell Biochem 107:144-54. 2009
    ..Ext1) and heparanase, as well as alters the relative expression of N-linked sulfotransferases (Ndst1 = Ndst2 > Ndst3) and enzymes mediating O-linked sulfation of heparan sulfate (Hs2st > Hs6st) or chondroitin sulfate (Cs4st > ..
  21. doi Glycanogenomics: a qPCR-approach to investigate biological glycan function
    Evelyn C Krenn
    Institute for Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, University of Graz, Universitatsplatz 1, A 8010 Graz, Austria
    Biochem Biophys Res Commun 375:297-302. 2008
    ..Major changes in expression patterns were found for the NDST3 and 3OST1 isoforms...
  22. ncbi [Analysis of aristolochic acid A from the aerial and underground parts of Asarum by UPLC-UV]
    Yan Xue
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Yao Xue Xue Bao 43:221-3. 2008
    ..method for the determination of aristolochic acid A in the aerial and underground parts of Asarum, an AcquityUPLC HSST3 column (50 mm x 2.1 mm ID, 1.8 microm) was used with the mobile phase of acetonitrile-0...
  23. pmc Altered heparan sulfate structure in mice with deleted NDST3 gene function
    Srinivas R Pallerla
    Department of General Zoology and Genetics, Westfalische Wilhelms Universitat Munster, Munster, Germany
    J Biol Chem 283:16885-94. 2008
    ..a targeted disruption of the heparan sulfate (HS)-modifying enzyme GlcNAc N-deacetylase/N-sulfotransferase 3 (NDST3)...
  24. ncbi Pasireotide--a somatostatin analog for the potential treatment of acromegaly, neuroendocrine tumors and Cushing's disease
    Anat Ben-Shlomo
    Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    IDrugs 10:885-95. 2007
    ..high binding affinity to four of the five human (h)SST receptor subtypes, with IC50 values for hSST5 > hSST2 > hSST3 > hSST1; the compound displays no affinity for hSST4...
  25. ncbi Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals?
    P Antunes
    Division of Radiological Chemistry, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Eur J Nucl Med Mol Imaging 34:982-93. 2007
    ..In preclinical studies it has shown a striking superiority over its 111In-labelled congener. The purpose of this study was to evaluate whether third-generation somatostatin-based, radiogallium-labelled peptides show the same superiority...
  26. ncbi Isolation of the structural genes for the alpha and beta subunits of the mitochondrial ATPase from the fission yeast Schizosaccharomyces pombe
    M Boutry
    J Biol Chem 259:2840-4. 1984
    ..These genes products reacted with an anti-F1-ATPase serum and therefore correspond most probably to precursors of the alpha and beta subunits...

Research Grants2

  1. Lianchun Wang; Fiscal Year: 2016
    ..Our studies further found that: 1). Slit3 is a novel angiogenic factor;2). T-Ndst1-/- and Ndst3-/- mice exhibit similar localized angiogenesis defect in diaphragm;3)...
  2. SYNTHESIS AND CONFORMATION OF PEPTIDE HORMONES
    Murray Goodman; Fiscal Year: 2003
    ..In addition computer simulated models of the hsst2, hsst3 and hsst5 receptors have provided insight into the nature of ligand-receptor interactions and allowed us to ..