NCR3

Summary

Gene Symbol: NCR3
Description: natural cytotoxicity triggering receptor 3
Alias: 1C7, CD337, LY117, MALS, NKp30, natural cytotoxicity triggering receptor 3, NK-p30, activating NK-A1 receptor, activating natural killer receptor p30, lymphocyte antigen 117, natural killer cell p30-related protein
Species: human

Top Publications

  1. ncbi Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells
    Elke Pogge von Strandmann
    Department of Internal Medicine I, University Hospital of Cologne, Kerpener Str 62, D 50924 Cologne, Germany
    Immunity 27:965-74. 2007
  2. ncbi Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Blood 107:2030-6. 2006
  3. doi Analysis of NK cell/DC interaction in NK-type lymphoproliferative disease of granular lymphocytes (LDGL): role of DNAM-1 and NKp30
    Mirna Balsamo
    DI ME S Dipartimento di Medicina Sperimentale, Universita di Genova, Genova, Italy
    Exp Hematol 37:1167-75. 2009
  4. pmc Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells
    D Pende
    Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    J Exp Med 190:1505-16. 1999
  5. ncbi Selective cross-talk among natural cytotoxicity receptors in human natural killer cells
    Raffaella Augugliaro
    Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Eur J Immunol 33:1235-41. 2003
  6. ncbi Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias
    Pegah Nowbakht
    Department of Research, Experimental Hematology, Basel University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
    Blood 105:3615-22. 2005
  7. ncbi NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor
    Massimo Vitale
    Istituto Scientifico per la Ricerca sul Cancro IST, Genova, Italy
    Blood 106:566-71. 2005
  8. ncbi A Duffy binding-like domain is involved in the NKp30-mediated recognition of Plasmodium falciparum-parasitized erythrocytes by natural killer cells
    Elie Mavoungou
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    J Infect Dis 195:1521-31. 2007
  9. pmc Expression analysis of the ligands for the Natural Killer cell receptors NKp30 and NKp44
    Andreina Byrd
    Institute for Immunology, University Heidelberg, Heidelberg, Germany
    PLoS ONE 2:e1339. 2007
  10. pmc The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans
    Cameron S Brandt
    Molecular and Cell Based Discovery, ZymoGenetics Inc, Seattle, WA 98102, USA
    J Exp Med 206:1495-503. 2009

Research Grants

  1. Mark D Sutton; Fiscal Year: 2016
  2. Static and dynamic light scattering instrumentation for macromolecular characteri
    Brian R Crane; Fiscal Year: 2010
  3. Expanding Data Collection Via High-Throughput DNA Sequencing
    Stephan C Schuster; Fiscal Year: 2010
  4. Ov D Slayden; Fiscal Year: 2014
  5. Roy A Mariuzza; Fiscal Year: 2014
  6. Anthracycline cardiotoxicity and calsequestrin function
    SUSAN SHADLE; Fiscal Year: 2002
  7. NK Cell Interactions in Transplantation
    SHERI KRAMS; Fiscal Year: 2005
  8. Synaptic signaling regulated by MALS family PDZ proteins
    Roger Nicoll; Fiscal Year: 2008
  9. AGING EFFECTS ON INTERMITTENT WORK CAPACITY
    Maury Nussbaum; Fiscal Year: 2002
  10. Facilitating Cells for Fetal Hematopoietic Transplant
    Laurence Shields; Fiscal Year: 2005

Detail Information

Publications199 found, 100 shown here

  1. ncbi Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells
    Elke Pogge von Strandmann
    Department of Internal Medicine I, University Hospital of Cologne, Kerpener Str 62, D 50924 Cologne, Germany
    Immunity 27:965-74. 2007
    The activity of natural killer (NK) cells is regulated by surface receptors, which direct target cell recognition. NKp30 (Natural Cytotoxicity Receptor 3) induces target cell lysis and is also crucial for the interaction with dendritic ..
  2. ncbi Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Blood 107:2030-6. 2006
    ..Remarkably, in cytolytic assays, DNAM-1 cooperated with NKp30 in the NK-mediated killing of both immature and mature DCs and the degree of contribution of DNAM-1 appeared to ..
  3. doi Analysis of NK cell/DC interaction in NK-type lymphoproliferative disease of granular lymphocytes (LDGL): role of DNAM-1 and NKp30
    Mirna Balsamo
    DI ME S Dipartimento di Medicina Sperimentale, Universita di Genova, Genova, Italy
    Exp Hematol 37:1167-75. 2009
    ..In this study, we analyze whether, in NK-lymphoproliferative disease of granular lymphocytes (LDGL) patients, this function could be altered and contribute to the persistence of the disease...
  4. pmc Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells
    D Pende
    Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    J Exp Med 190:1505-16. 1999
    ..In this study, by the generation of monoclonal antibodies (mAbs), we identified NKp30, a novel 30-kD triggering receptor selectively expressed by all resting and activated human natural killer (NK) ..
  5. ncbi Selective cross-talk among natural cytotoxicity receptors in human natural killer cells
    Raffaella Augugliaro
    Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Eur J Immunol 33:1235-41. 2003
    ..These receptors include NKp46, NKp30 and NKp44, collectively termed natural cytotoxicity receptors (NCR)...
  6. ncbi Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias
    Pegah Nowbakht
    Department of Research, Experimental Hematology, Basel University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
    Blood 105:3615-22. 2005
    ..To detect as-yet-unknown cell-surface molecules recognized by NCRs, we developed soluble forms of NKp30, NKp44, and NKp46 as staining reagents binding the putative cognate ligands...
  7. ncbi NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor
    Massimo Vitale
    Istituto Scientifico per la Ricerca sul Cancro IST, Genova, Italy
    Blood 106:566-71. 2005
    ..While killing of immature DCs is dependent on the function of the NKp30 triggering receptor, the mechanism by which NK cells induce DC maturation is still unclear...
  8. ncbi A Duffy binding-like domain is involved in the NKp30-mediated recognition of Plasmodium falciparum-parasitized erythrocytes by natural killer cells
    Elie Mavoungou
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    J Infect Dis 195:1521-31. 2007
    ..We showed that with NKp30-immunoglobulin and NKp46-immunoglobulin fusion proteins and DBL-1alpha peptides NCRs are involved in the NK cell-..
  9. pmc Expression analysis of the ligands for the Natural Killer cell receptors NKp30 and NKp44
    Andreina Byrd
    Institute for Immunology, University Heidelberg, Heidelberg, Germany
    PLoS ONE 2:e1339. 2007
    ..Identification of NCR ligands and their level of expression on normal and neoplastic cells has important implications for the rational design of immunotherapy strategies for cancer...
  10. pmc The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans
    Cameron S Brandt
    Molecular and Cell Based Discovery, ZymoGenetics Inc, Seattle, WA 98102, USA
    J Exp Med 206:1495-503. 2009
    ..We report the identification of a tumor cell surface molecule that binds NKp30, a human receptor which triggers antitumor NK cell cytotoxicity and cytokine secretion...
  11. ncbi A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC
    M J Neville
    Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, United Kingdom
    J Immunol 162:4745-54. 1999
    ..10 known genes in this region have been precisely positioned with the order allograft inflammatory factor 1, G1, 1C7, leukocyte-specific transcript 1 (B144), lymphotoxin B, TNF, lymphotoxin A, NB6, IKBL, BAT1 (centromere to telomere)..
  12. ncbi Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan
    Hilary S Warren
    Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    J Immunol 175:207-12. 2005
    NKp30 (NCR3, CD337) is a natural cytotoxicity receptor, expressed on subsets of human peripheral blood NK cells, involved in NK cell killing of tumor cells and immature dendritic cells...
  13. pmc Dendritic cells release HLA-B-associated transcript-3 positive exosomes to regulate natural killer function
    Venkateswara Rao Simhadri
    Laboratory of Immune Therapy, Department of Internal Medicine I, Centre for Integrated Oncology Koeln Bonn, University of Cologne, Cologne, Germany
    PLoS ONE 3:e3377. 2008
    b>NKp30, a natural cytotoxicity receptor expressed on NK cells is critically involved in direct cytotoxicity against various tumor cells and directs both maturation and selective killing of dendritic cells...
  14. ncbi Genes in a 220-kb region spanning the TNF cluster in human MHC
    S R Nalabolu
    Boyer Center for Molecular Medicine, New Haven, Connecticut 06536 0812, USA
    Genomics 31:215-22. 1996
    ..We also independently identified the BAT1 gene to be the well-conserved homologue of a previously described rat liver nuclear protein...
  15. pmc Activation of natural killer cells by newcastle disease virus hemagglutinin-neuraminidase
    Mostafa Jarahian
    German Cancer Research Center, Heidelberg, Germany
    J Virol 83:8108-21. 2009
    ..cells showed enhanced expression of ligands for the natural cytotoxicity receptors NKp44 and NKp46, but not NKp30. Ligands for the activating receptor NKG2D were partially downregulated...
  16. ncbi Functional modifications of the CD4+ and the CD8+ subset due to maternal serum
    Y E Vanderbeeken
    Service d' Immunologie, , Brussels, Belgium
    Immunopharmacol Immunotoxicol 11:397-420. 1989
    ..of a pool of maternal serum, retroplacental (MAT SR) or peripheral (MAT SP), or to a pool of male or calf serum (MALS or CS)...
  17. doi Multi-crystallin complexes exist in the water-soluble high molecular weight protein fractions of aging normal and cataractous human lenses
    K Srivastava
    Department of Vision Sciences, University of Alabama at Birmingham, Worrell Bldg, 924 S 18th Street, Birmingham, AL 35294, USA
    Exp Eye Res 87:356-66. 2008
    ..During multi-angle light scattering (MALS), the HMW proteins from cataractous lenses exhibited species with lower molecular weight range than age-matched ..
  18. ncbi Phenotypic and cytolytic activity of Macaca nemestrina natural killer cells isolated from blood and expanded in vitro
    Laurence E Shields
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Am J Primatol 68:753-64. 2006
    ..Subsets of these cells express CD56, NKp30, and NKp46...
  19. pmc X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells
    S Parolini
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Brescia, 25123 Brescia, Italy
    J Exp Med 192:337-46. 2000
    ..Other receptors involved in NK cell triggering, including CD16, NKp46, NKp44, and NKp30, displayed a normal functional capability...
  20. doi Brief report--human embryonic stem cell-derived mesenchymal progenitors possess strong immunosuppressive effects toward natural killer cells as well as T lymphocytes
    B Linju Yen
    Regenerative Medicine Research Group, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
    Stem Cells 27:451-6. 2009
    ..and can suppress the cytotoxic effects of activated NKs, as well as downregulating the NK-activating receptors NKp30 and NKp46...
  21. ncbi Determining the absolute, chemical-heterogeneity-corrected molar mass averages, distribution, and solution conformation of random copolymers
    Imad A Haidar Ahmad
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, 32306 4390, USA
    Anal Bioanal Chem 396:1589-98. 2010
    ..of separation by size-exclusion chromatography (SEC) with detection using multi-angle static light scattering (MALS), differential viscometry (VISC), differential refractometry (DRI), and ultraviolet absorption spectroscopy (UV) ..
  22. ncbi Retention behaviour of amylopectins in asymmetrical flow field-flow fractionation studied by multi-angle light scattering detection
    M van Bruijnsvoort
    Division of Technical Analytical Chemistry, Centre for Chemistry and Chemical Engineering, Lund University, Sweden
    J Chromatogr A 925:171-82. 2001
    Asymmetrical flow field-flow fractionation (FFF) with multi-angle light scattering (MALS) detection was applied for the fractionation of amylopectins from four different sources...
  23. ncbi Complex analytical approach to characterization of the influence of carbon dioxide concentration on carbohydrate composition in Norway spruce needles
    Jana Cabálková
    Institute of Analytical Chemistry v v i, Academy of Sciences of the Czech Republic, Department of Proteomics, Veveri 97, Brno CZ 60200, Czech Republic
    J Chromatogr A 1148:189-99. 2007
    ..Application of AsFlFFF and SEC, using refractive index (RI) and multi-angle light scattering (MALS) detectors to the water-rich extracts resulted in three or four main fractions covering molar masses from 10(3) to ..
  24. ncbi Immunohistochemical detection and distribution of enamelysin (MMP-20) in human odontogenic tumors
    T Takata
    Department of Oral Pathology, Faculty of Dentistry, Hiroshima University, Japan
    J Dent Res 79:1608-13. 2000
    ..A monoclonal antibody (203-1C7) was generated against synthesized human enamelysin oligopeptide and was used to assess the immunolocalization of ..
  25. pmc Selectable tolerance to herbicides by mutated acetolactate synthase genes integrated into the chloroplast genome of tobacco
    Masanori Shimizu
    Graduate School of Nutritional and Environmental Science, University of Shizuoka, Shizuoka 422 8526, Japan
    Plant Physiol 147:1976-83. 2008
    ..We generated a series of Arabidopsis (Arabidopsis thaliana) mutated ALS (mALS) genes and introduced constructs with mALS and the aminoglycoside 3'-adenyltransferase gene (aadA) into the tobacco ..
  26. ncbi [Treatment of celiac and mesenteric arteries stenoses with interventional radiologic techniques]
    Mao Qiang Wang
    Department of Interventional Radiology, People s Liberation Army General Hospital, Beijing 100853, China
    Zhonghua Wai Ke Za Zhi 43:1132-5. 2005
    ..To evaluate the safety and efficacy of the interventional techniques for management of celiac and mesenteric arteries stenoses...
  27. doi Human CD80/IL2 lentivirus-transduced acute myeloid leukaemia (AML) cells promote natural killer (NK) cell activation and cytolytic activity: implications for a phase I clinical study
    Wendy Ingram
    Department of Haematological Medicine, King s College London, London, UK
    Br J Haematol 145:749-60. 2009
    ..Expression of the activation receptors NKp30, NKp44, CD244, CD25, CD69 and HLA-DR significantly increased following allogeneic culture and a consistent ..
  28. ncbi IGF-1 gene transfer into denervated rat laryngeal muscle
    P W Flint
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21203 6402, USA
    Arch Otolaryngol Head Neck Surg 125:274-9. 1999
    ....
  29. doi Combining asymmetrical flow field-flow fractionation with light-scattering and inductively coupled plasma mass spectrometric detection for characterization of nanoclay used in biopolymer nanocomposites
    B Schmidt
    Department of Basic Sciences and Environment, University of Copenhagen, Frederiksberg, C DK 1871, Denmark
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 26:1619-27. 2009
    ..system combining asymmetrical flow field-flow fractionation (AF(4)) with multi-angle light-scattering detection (MALS) and inductively coupled plasma mass spectrometry (ICP-MS) is presented...
  30. doi Extraction of hyaluronic acid (HA) from rooster comb and characterization using flow field-flow fractionation (FlFFF) coupled with multiangle light scattering (MALS)
    Dong Young Kang
    Department of Chemistry, Hannam University, Daejeon, Korea
    J Sep Sci 33:3530-6. 2010
    ..20×10(6) and 94.7 nm, respectively. When the sample solution was filtered through a 0.45 μm disposable syringe filter, they were reduced down to 3.8×10(5) and 50.1 nm, respectively...
  31. ncbi SEC-MALS characterization of microbial polyhydroxyalkanoates
    Ema Zagar
    National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia
    Biomacromolecules 5:628-36. 2004
    ..was performed using size exclusion chromatography coupled to a multi-angle light scattering detector (SEC-MALS). Absolute molar mass averages, molar mass distribution, and the radius of gyration were determined...
  32. doi Quaternary size distribution of soluble aggregates of glutathione-S-transferase-purified viral protein as determined by asymmetrical flow field flow fractionation and dynamic light scattering
    Daniel I Lipin
    Centre for Biomolecular Engineering, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Chromatogr A 1190:204-14. 2008
    ..10(3)kDa), as determined by asymmetrical flow field flow fractionation with multiple angle light scattering (AFFFF-MALS)...
  33. doi Asymmetrical flow field-flow fractionation with multi-angle light scattering detection for the analysis of structured nanoparticles
    Andrea Zattoni
    Department of Chemistry G Ciamician, University of Bologna, via F Selmi 2, I 40126 Bologna, Italy
    J Chromatogr A 1216:9106-12. 2009
    ..Asymmetrical flow field-flow fractionation (AF4) with multi-angle light scattering (MALS) detection is able to size-separate and to characterize nanosized analytes in dispersion...
  34. doi Field validation of a competitive ELISA for detection of Theileria annulata infection
    Stefanie Renneker
    Veterinary Infection Biology and Immunology, Research Center Borstel, Parkallee 22, 23845, Borstel, Germany
    Parasitol Res 106:47-53. 2009
    ..specificity, a competitive ELISA (cELISA) was developed using recombinant TaSP antigen and a monoclonal antibody (1C7) specifically binding to TaSP. Since the cELISA accurately differentiated T...
  35. ncbi Comparative evaluation of size-exclusion chromatography and viscometry for the characterisation of cellulose
    Anne Laurence Dupont
    Centre de Recherches sur la Conservation, Centre National de la Recherche Scientifique, Ministère de la Culture et de la Communication, Museum national d histoire naturelle, 75005 Paris, France
    J Chromatogr A 1026:129-41. 2004
    The analysis using size-exclusion chromatography (SEC) with multi-angle light scattering (MALS) and differential refractive index (DRI) detection of cellulose dissolved in lithium chloride/N,N-dimethylacetamide (LiCI/DMAc) is evaluated ..
  36. ncbi Distribution analysis of ultra-high molecular mass poly(ethylene oxide) containing silica particles by size-exclusion chromatography with dual light-scattering and refractometric detection
    Bedrich Porsch
    Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq 2, 16206 Prague 6, Czech Republic
    J Chromatogr A 1068:249-60. 2005
    ..SEC) systems, connected in-line either to a low-angle light scattering (LALS) or to a multiangle light scattering (MALS) detector, are employed for determination of molecular mass distributions (MMD) of poly(ethylene oxide) (PEO) ..
  37. ncbi Masticatory function after unilateral distal extension removable partial denture treatment: intra-individual comparison with opposite dentulous side
    Wacharasak Tumrasvin
    Removable Prosthodontics, Department of Masticatory Function Rehabilitation, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Japan
    J Med Dent Sci 52:35-41. 2005
    ..Both masticatory parameters were evaluated separately on each chewing side. MAls and MBFs obtained from the RPD replaced side (0.65 +/- 0...
  38. ncbi Reliability and validity of the upper-extremity Motor Activity Log-14 for measuring real-world arm use
    Gitendra Uswatte
    Department of Psychology, University of Alabama, Birmingham, AL 35294, USA
    Stroke 36:2493-6. 2005
    ..This article examines the psychometrics of the 14-item version of this instrument in 2 chronic stroke samples with mild-to-moderate upper-extremity hemiparesis...
  39. doi Particle size characterization by quadruple-detector hydrodynamic chromatography
    Amandaa K Brewer
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, 32306 4390, USA
    Anal Bioanal Chem 393:295-302. 2009
    ..a quadruple-detector hydrodynamic chromatography (HDC) method utilizing static multiangle light scattering (MALS), quasi-elastic light scattering (QELS), differential viscometry (VISC), and differential refractometry (DRI), and ..
  40. doi Physicochemical features of ultra-high viscosity alginates
    Henning Storz
    Institute for Technical and Macromolecular Chemistry, University of Hamburg, Hamburg, Germany
    Carbohydr Res 344:985-95. 2009
    ..Fluorescence and (1)H NMR spectroscopies, viscometry, and multi-angle light scattering (MALS) were used for elucidation of the chemical structure, molar mass, and coil size...
  41. doi Identification of the transcription factor responsible for L-malate-dependent regulation in the marine Antarctic bacterium Pseudoalteromonas haloplanktis TAC125
    Rosanna Papa
    Department of Public Health Sciences, La Sapienza University, Rome, Italy
    FEMS Microbiol Lett 295:177-86. 2009
    ..Recently, a functionally active two-component system consisting of malS and malR genes possibly involved in the expression of a C4-dicarboxylate transporter system (dctAB operon) was ..
  42. pmc Natural killer cell dysfunction during acute infection with foot-and-mouth disease virus
    Felix N Toka
    Plum Island Animal Disease Center, Agricultural Research Service, USDA, Greenport, New York 11944, USA
    Clin Vaccine Immunol 16:1738-49. 2009
    ..animals are not productively infected, but virus exposure in vivo resulted in the significant induction of NKp30 and Toll-like receptor 3 expression and the moderate activation of SOCS3 and interleukin-15 receptor mRNA...
  43. doi Celiac revascularization as a requisite for treating the median arcuate ligament syndrome
    Xiujie Wang
    Department of Surgery, Englewood Hospital and Medical Center, Englewood, NJ 07631, USA
    Ann Vasc Surg 22:571-4. 2008
    Median arcuate ligament syndrome (MALS) is a rare and often misunderstood condition characterized by compression of the proximal portion of the celiac artery by the median arcuate ligament...
  44. doi The application of the mutated acetolactate synthase gene from rice as the selectable marker gene in the production of transgenic soybeans
    Makoto Tougou
    National Agricultural Research Center for Tohoku Region NARCT, Morioka, Iwate, Japan
    Plant Cell Rep 28:769-76. 2009
    ..system, we used the acetolactate synthase (ALS)-inhibiting herbicide-resistance gene derived from rice (Os-mALS gene) as a selectable marker gene instead of that derived from bacteria, which interfered with the cultivation and ..
  45. doi The natural cytotoxicity receptor NKp46 is dispensable for IL-22-mediated innate intestinal immune defense against Citrobacter rodentium
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris, France
    J Immunol 183:6579-87. 2009
    Natural cytotoxicity receptors (including NKp30, NKp44, and NKp46 in humans and NKp46 in mice) are type I transmembrane proteins that signal NK cell activation via ITAM-containing adapter proteins in response to stress- and pathogen-..
  46. ncbi Isolates of Theileria annulata collected from different parts of India show phenotypic and genetic diversity
    A Manuja
    Department of Veterinary Epidemiology and Preventive Medicine, CCS Haryana Agricultural University, Hisar 125004, Haryana, India
    Vet Parasitol 137:242-52. 2006
    ..Phenotypic polymorphism was also revealed by T. annulata schizont-specific monoclonal antibodies (Mabs), viz. 1C7, 1E11, 2G2 and EU-106, which recognized variable number of cells in indirect fluorescent antibody and indirect ..
  47. doi A detailed analysis of biodegradable nanospheres by different techniques--a combined approach to detect particle sizes and size distributions
    Christian Augsten
    Martin Luther University of Halle Wittenberg, Institute of Pharmacy, 06120 Halle, Germany
    J Pharm Biomed Anal 47:95-102. 2008
    ..The flow field-flow fractionation (FlFFF) fractograms in combination with multi-angle light scattering (MALS) allowed an easy detection of maximum particle sizes what is most important for parenteral systems...
  48. doi Quantitative characterization of virus-like particles by asymmetrical flow field flow fractionation, electrospray differential mobility analysis, and transmission electron microscopy
    Leonard F Pease
    National Institute of Standards and Technology NIST, Gaithersburg, Maryland, USA
    Biotechnol Bioeng 102:845-55. 2009
    ..analysis (ES-DMA), asymmetric flow field-flow fractionation with multi-angle light scattering detection (AFFFF-MALS) and transmission electron microscopy (TEM)...
  49. doi Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure
    Yong Zou
    Department of Infectious Disease, Institute of Infectious Disease, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Immunol 184:466-75. 2010
    ..the accumulation of hepatic NK cells and increased expression of FasL and natural cytotoxicity receptors (NKp30 and NKp46) on the peripheral NK cells from patients with HBV-ACLF were correlated with disease progression...
  50. pmc Fatal cases of Theileria annulata infection in calves in Portugal associated with neoplastic-like lymphoid cell proliferation
    Sandra Branco
    Instituto de Ciências Agrárias e Ambientais Mediterrânicas, Departamento de Medicina Veterinaria, Universidade de Evora, Pólo da Mitra, Ap 94, Evora, Portugal
    J Vet Sci 11:27-34. 2010
    ..annulata infected cells in these nodules were also identified by IHC through the use of two monoclonal antibodies (1C7 and 1C12) which are diagnostic for the parasite...
  51. ncbi A topological model of the baseplate of lactococcal phage Tuc2009
    Giuliano Sciara
    Architecture et Fonction des Macromolecules Biologiques, UMR 6098 CNRS, 163 Avenue de Luminy Case 932, Marseille Cedex 09, France
    J Biol Chem 283:2716-23. 2008
    ..chromatography coupled to on-line UV-visible absorbance, light scattering, and refractive index detection (MALS/UV/RI)...
  52. doi Anticoagulant activity of a sulfated polysaccharide from the green alga Arthrospira platensis
    Hatem Majdoub
    Laboratoire Polymères, Biopolymères et Matériaux Organiques, Faculte des Sciences, Monastir, 5000 Monastir, Tunisia
    Biochim Biophys Acta 1790:1377-81. 2009
    ..The polysaccharide of culture medium from Arthrospira platensis was extracted by ultrafiltration, partially characterized and assayed for anticoagulant activity...
  53. ncbi Association of HLA-A*3303-B*4403-DRB1*1302 haplotype, but not of TNFA promoter and NKp30 polymorphism, with postherpetic neuralgia (PHN) in the Japanese population
    M Sato
    Department of Research, Tokyo Metropolitan Red Cross Blood Center, Tokyo, 150 0012 Japan
    Genes Immun 3:477-81. 2002
    ..HLA-A, -B, -DRB1, tumor necrosis factor alpha (TNFA) promoter, and a natural killer cell activating receptor, NKp30 polymorphisms with PHN...
  54. ncbi Characterization of gelatine and acid soluble collagen by size exclusion chromatography coupled with multi angle light scattering (SEC-MALS)
    Michael Meyer
    Forschungsinstitut für Leder und Kunststoffbahnen gGmbH, Meissner Ring 1 5, D 09599 Freiberg, Germany
    Biomacromolecules 4:1727-32. 2003
    ..hide gelatine were analyzed by size exclusion chromatography (SEC) coupled with multi angle light scattering (MALS). The SEC system was calibrated with ASC and its cyan bromide cleavage products...
  55. doi Characterization of high-molecular-weight nonnative aggregates and aggregation kinetics by size exclusion chromatography with inline multi-angle laser light scattering
    Yi Li
    Department of Chemical Engineering, University of Delaware, Newark, Delaware 19716, USA
    J Pharm Sci 98:3997-4016. 2009
    Size exclusion chromatography with an inline multi-angle light scattering detector (SEC-MALS) was assessed as a means to characterize and monitor the formation of soluble, high-molecular-weight (HMW) protein aggregates so as to better ..
  56. ncbi Molecular characterization of the MalT-dependent periplasmic alpha-amylase of Escherichia coli encoded by malS
    E Schneider
    Department of Biology, University of Konstanz, Federal Republic of Germany
    J Biol Chem 267:5148-54. 1992
    b>malS, the gene encoding the periplasmic alpha-amylase, is under the regulatory control of the MalT protein, the gene activator of the Escherichia coli maltose system. We sequenced the DNA region encoding malS and its control elements...
  57. ncbi Aggregation of recombinant bovine granulocyte colony stimulating factor in solution
    Richard Bartkowski
    Pfizer Global Manufacturing, Quality Operations, Groton, Connecticut 06340, USA
    J Protein Chem 21:137-43. 2002
    ..rbG-CSF) was examined by the techniques of size exclusion chromatography (SEC), multiangle laser light scattering (MALS), and SDS-PAGE...
  58. ncbi Role of NK cell-activating receptors and their ligands in the lysis of mononuclear phagocytes infected with an intracellular bacterium
    Ramakrishna Vankayalapati
    Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler 75708, USA
    J Immunol 175:4611-7. 2005
    ..Expression of the activating receptors NKp30, NKp46, and NKG2D were enhanced on NK cells by exposure to M...
  59. ncbi Human NK cytotoxicity against porcine cells is triggered by NKp44 and NKG2D
    Pietro Forte
    Department of Internal Medicine, Laboratory for Transplantation Immunology, University Hospital Zurich, Zurich, Switzerland
    J Immunol 175:5463-70. 2005
    ..The aim of the present study was to analyze the role of activating NK receptors including NKp30, NKp44, NKp46, and NKG2D in human xenogeneic NK cytotoxicity against porcine endothelial cells (pEC)...
  60. pmc NKp30 is a functional activation receptor on a subset of rat natural killer cells
    Christine L Hsieh
    Department of Surgery, Division of Transplantation and Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305 5492, USA
    Eur J Immunol 36:2170-80. 2006
    b>NKp30 is a stimulatory receptor on human NK cells implicated in tumor immunity, and is capable of promoting or terminating dendritic cell maturation...
  61. pmc Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection
    Domenico Mavilio
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:2339-50. 2006
    ..In this regard, the markedly impaired expression/secretion and function of NKp30 and TNF-related apoptosis-inducing ligand, particularly among the CD56(neg) NK cell subset, largely accounts for ..
  62. ncbi NKG2D and natural cytotoxicity receptors are involved in natural killer cell interaction with self-antigen presenting cells and stromal cells
    Alessandro Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, c o CBA Torre A1, Largo R Benzi 10, 16132 Genoa, Italy
    Ann N Y Acad Sci 1109:47-57. 2007
    ..The natural cytotoxicity receptors NKp30 and NKp46 are responsible for the delivery of lethal hit to APC, whereas NKG2D-activating receptor, the ligand of ..
  63. ncbi Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2
    Grazia Maria Spaggiari
    Centro di Eccellenza per la Ricerca Biomedica, Biologia e Genetica, Universita di Genova, Genova, Italy
    Blood 111:1327-33. 2008
    ..inhibitory effect is related to a sharp down-regulation of the surface expression of the activating NK receptors NKp30, NKp44, and NKG2D...
  64. doi Natural cytotoxicity receptors NKp30, NKp44 and NKp46 bind to different heparan sulfate/heparin sequences
    Marie Lyn Hecht
    Laboratory for Organic Chemistry, Swiss Federal Institute of Technology ETH Zurich, 8093 Zurich, Switzerland
    J Proteome Res 8:712-20. 2009
    ..One important family of activating receptors is the natural cytotoxicity receptors (NCRs) which include NKp30, NKp44 and NKp46. The NCRs initiate tumor targeting by recognition of heparan sulfate on cancer cells...
  65. pmc Natural killer lysis receptor (NKLR)/NKLR-ligand matching as a novel approach for enhancing anti-tumor activity of allogeneic NK cells
    Gal Markel
    Ella Institute of Melanoma, Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel
    PLoS ONE 4:e5597. 2009
    ..Here we suggest an alternative approach for augmentation of anti tumor effect of allogeneic NK cells, which is founded on profile matching of donor NK lysis receptors (NKLR) phenotype with tumor lysis-ligands...
  66. pmc Impaired plasmacytoid dendritic cell (PDC)-NK cell activity in viremic human immunodeficiency virus infection attributable to impairments in both PDC and NK cell function
    Sara J Conry
    Department of Medicine, Case Western Reserve University Center for AIDS Research, University Hospitals of Cleveland, OH, USA
    J Virol 83:11175-87. 2009
    ..and this defect was not attributable to diminished IFN-alpha receptor expression, though IFN-alpha receptor and NKP30 expression was closely associated with killer activity in viremic HIV infection but not in healthy controls...
  67. pmc MALS: an efficient strategy for multiple site-directed mutagenesis employing a combination of DNA amplification, ligation and suppression PCR
    Alexey A Fushan
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Biotechnol 9:83. 2009
    ..In addition, many of the existing multiple SDM methods have technical limitations associated with type and number of mutations that can be introduced, or are technically demanding and require special chemical reagents...
  68. doi Early evaluation of natural killer activity in post-transplant acute myeloid leukemia patients
    G Pittari
    INSERM U753, Institut Gustave Roussy, Villejuif, France
    Bone Marrow Transplant 45:862-71. 2010
    ..Decreased NK activity in AML patients was concomitant to NKp46 and NKp30 down-regulation. AML NK cells were chronically exposed to low IL-2 levels following HSCT...
  69. doi Soluble HLA-I-mediated secretion of TGF-beta1 by human NK cells and consequent down-regulation of anti-tumor cytolytic activity
    Massimo Ghio
    Department of Internal Medicine, University of Genoa and San Martino Hospital of Genoa, 16132 Italy
    Eur J Immunol 39:3459-68. 2009
    ..inhibited NK cell cytolysis induced by the engagement of stimulatory receptors including NKG2D, DNAM1, 2B4, CD69, NKp30, NKp44 and NKp46. The IL-2-dependent surface upregulation of some of these receptors was prevented by TGF-beta1...
  70. doi Liposome fractionation and size analysis by asymmetrical flow field-flow fractionation/multi-angle light scattering: influence of ionic strength and osmotic pressure of the carrier liquid
    Stefan Hupfeld
    Drug Transport and Delivery Group, Department of Pharmacy, University of Tromsø, N 9037 Tromsø, Norway
    Chem Phys Lipids 163:141-7. 2010
    Asymmetrical flow field-flow fractionation (AsFlFFF)/multi-angle light scattering (MALS) was employed for studying filter-extruded liposomes in carrier solutions with different ionic strength and osmolarity...
  71. doi CD56highCD16-CD62L- NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses
    Teresa Carbone
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    J Immunol 184:1102-10. 2010
    ..NKG2A, intermediate to high levels of perforin, and the activating receptors, NKG2D, NKp44, and NKp46, but lacked NKp30 and killer Ig-related receptors...
  72. pmc Inhibition of human natural killer cell activity by influenza virions and hemagglutinin
    Huawei Mao
    Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Rm L7 58, 7 F Laboratory Block, Faculty of Medicine Building, 21 Sassoon Rd, Hong Kong
    J Virol 84:4148-57. 2010
    ..zeta chain through the lysosomal pathway, which caused the decrease of NK cell cytotoxicity mediated by NKp46 and NKp30. The underlying dysregulation of the signaling pathway involved zeta chain downregulation, leading to decreased ..
  73. doi The association of MHC class I proteins with the 2B4 receptor inhibits self-killing of human NK cells
    Gili Betser-Cohen
    The Lautenberg Center for General and Tumor Immunology, The Institute for Medical Research Israel Canada, Hebrew University Hadassah Medical School, Jerusalem, Israel
    J Immunol 184:2761-8. 2010
    The killing activity of NK cells is carried out by several activating NK receptors, which includes NKp46, NKp44, NKp30, NKp80, NKG2D, and 2B4...
  74. doi Revealing the size, conformation, and shape of casein micelles and aggregates with asymmetrical flow field-flow fractionation and multiangle light scattering
    Maria Glantz
    Department of Food Technology, Engineering and Nutrition, Lund University, P O Box 124, SE 221 00 Lund, Sweden
    Langmuir 26:12585-91. 2010
    ..distribution using asymmetrical flow field-flow fractionation (AsFlFFF) connected to multiangle light scattering (MALS) and refractive index (RI) detection...
  75. doi Hydrodynamic versus size exclusion chromatography characterization of alternan and comparison to off-line MALS
    Samantha L Isenberg
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306 4390, USA
    Biomacromolecules 11:2505-11. 2010
    ..Results from packed-column HDC with multiangle static light scattering (MALS) detection compare favorably to results from off-line MALS analysis, and HDC results are obtained in a fraction of ..
  76. pmc A novel statistic for genome-wide interaction analysis
    Xuesen Wu
    Department of Epidemiology and Statistics, Bengbu Medical College at Bengbu, Anhui, China
    PLoS Genet 6:e1001131. 2010
    ..These included five interacting pairs of SNPs in genes LST1/NCR3, CXCR5/BCL9L, and GLS2, some of which were located in the target sites of miR-324-3p, miR-433, and miR-382, as well ..
  77. doi Complete physicochemical characterization of DNA/chitosan complexes by multiple detection using asymmetrical flow field-flow fractionation
    Pei Lian Ma
    Department of Chemical Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal, P O 6079 Succursale Centre Ville, Montreal, Quebec, Canada H3C 3A7
    Anal Chem 82:9636-43. 2010
    Asymmetrical flow field-flow fractionation (AF4) coupled with UV-vis spectrophotometry, multiangle light scattering (MALS), and dynamic light scattering (DLS) detection was used to analyze dispersions of DNA/rhodamine B labeled chitosan (..
  78. doi Single walled carbon nanotube length determination by asymmetrical-flow field-flow fractionation hyphenated to multi-angle laser-light scattering
    Julien Gigault
    Université de Pau et des Pays de l Adour UPPA CNRS, Laboratoire de Chimie Analytique Bio Inorganique et Environnement, UMR IPREM 5254, Technopôle Hélioparc, Av Du président Angot, 64000 Pau, France
    J Chromatogr A 1217:7891-7. 2010
    Asymmetrical flow field-flow fractionation (AFlFFF) hyphenated to multi-angle laser-light scattering (MALS) was evaluated in order to determine single walled carbon nanotube (SWCNT) length distribution...
  79. doi Size, structure and scaling relationships in glycogen from various sources investigated with asymmetrical flow field-flow fractionation and 1H NMR
    Celine Fernandez
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    Int J Biol Macromol 49:458-65. 2011
    ..Furthermore, the results display the strength of the apparent density (as obtained from AsFlFFF-MALS-RI) as a characterization parameter for scaling in disperse macromolecules.
  80. doi Apico-basal polarity in polycystic kidney disease epithelia
    Patricia D Wilson
    UCL Medical School, Royal Free Hospital, London, UK
    Biochim Biophys Acta 1812:1239-48. 2011
    ..AJ, FA and polarity complexes in ADPKD epithelia include loss of E-cadherin, and focal adhesion kinase (FAK), MALS-3, Crb and Dlg complexes as well as disruptions in Rab/sec and syntaxin trafficking and membrane docking pathways...
  81. doi External compression of the superior mesenteric artery by the median arcuate ligament
    Jeffrey J Stein
    Division of Vascular Surgery, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Vasc Endovascular Surg 45:565-7. 2011
    ..artery (SMA) in addition to the celiac artery represents an unusual variant of median arcuate ligament syndrome (MALS). We present a case of MALS resulting predominantly from external compression of the SMA...
  82. doi Use of a callus-specific selection system to develop transgenic rice seed accumulating a high level of recombinant protein
    Yuhya Wakasa
    Transgenic Crop Research and Development Center, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    Methods Mol Biol 847:467-79. 2012
    A mutated rice acetolactate synthase (mALS) gene expressed under the control of the rice callus-specific promoter (CSP) (CSP:mALS) becomes a useful selectable marker for producing transgenic rice seed with higher accumulation of ..
  83. doi Malate metabolism in Bacillus subtilis: distinct roles for three classes of malate-oxidizing enzymes
    Frederik M Meyer
    Department of General Microbiology, Institute of Microbiology and Genetics, Georg August University Gottingen, Gottingen, Germany
    FEMS Microbiol Lett 339:17-22. 2013
    ..Finally, the NADH-generating malic enzymes MaeA, MalS, and MleA are involved in keeping the ATP levels high...
  84. doi Ex vivo expansion of highly cytotoxic human NK cells by cocultivation with irradiated tumor cells for adoptive immunotherapy
    Seon Ah Lim
    Global Research Laboratory, Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, Korea
    Cancer Res 73:2598-607. 2013
    ..Marked elevations in expression of activation receptors, natural cytotoxicity receptors (NKp30, NKp44), and adhesion molecules (CD11a, ICAM-1) were associated with high tumor-lytic capacity, in both in vitro ..
  85. pmc Expression patterns of killer cell immunoglobulin-like receptors (KIR) of NK-cell and T-cell subsets in Old World monkeys
    Meike Hermes
    Primate Genetics Laboratory, German Primate Center, Leibniz Institute for Primate Research, Gottingen, Germany
    PLoS ONE 8:e64936. 2013
    ..of KIR on NK and T cell subsets in rhesus macaques and differences between individuals using pan-KIR3D antibody 1C7 and antibodies specific for single KIR...
  86. doi Mature cytotoxic CD56(bright)/CD16(+) natural killer cells can infiltrate lymph nodes adjacent to metastatic melanoma
    Meriem Messaoudene
    Authors Affiliations Inserm U1016, CNRS UMR 8104, Institut Cochin APHP, Department of Dermatology, Hospital Cochin, University Paris Descartes APHP, Department of Dermatology APHP, Department of Surgery, Hospital Bichat, University Paris Diderot Surgery Department, Institut Curie, rue d Ulm Paris Hospital Foch, Suresnes Centre de Recherche des Cordeliers, 15 rue de l école de médecine and INSERM U1015 INSERM, Institut Gustave Roussy, Villejuif, Paris, France
    Cancer Res 74:81-92. 2014
    ..Expression of NCR-NKp30 and NKG2D correlated negatively with percentages of tumor cells in M-LN...
  87. doi Inhibition of NKp30- and 2B4-mediated NK cell activation by evolutionary different human and bovine CEACAM1 receptors
    Wolfgang Merkt
    Institute for Immunology, University Heidelberg, Heidelberg, Germany
    Eur J Immunol 45:2134-42. 2015
    ..We show that in addition to NKG2D, human CEACAM1 can inhibit NK-cell activation via NKp30 or 2B4. Bovine CEACAM1, possessing an ITIM and an ITSM signaling motif, is also inhibitory...
  88. doi Size and concentration determination of (functionalised) fullerenes in surface and sewage water matrices using field flow fractionation coupled to an online accurate mass spectrometer: method development and validation
    Pol Herrero
    KWR Watercycle Research Institute, P O Box 1072, 3430 BB Nieuwegein, The Netherlands Department of Analytical Chemistry and Organic Chemistry, Universitat Rovira i Virgili, Sescelades Campus, Marcel li Domingo s n, 43007 Tarragona, Spain
    Anal Chim Acta 871:77-84. 2015
    ..The multi-angle light scattering (MALS) data received after employing the ammonia solution was consistent with both the theory and calibration using well ..
  89. pmc Analysis of exosome release as a cellular response to MAPK pathway inhibition
    K Agarwal
    William G Lowrie Department of Chemical and Biomolecular Engineering, Department of Chemistry, Nanoscale Science and Engineering Center for Affordable Nanoenginering of Polymeric Biomedical Devices, Department of Internal Medicine, Division of Endocrinology Diabetes and Metabolism, Arthur G James Comprehensive Cancer Center and Richard G Solove Research Institute, The Ohio State University, Columbus, Ohio 43210, United States
    Langmuir 31:5440-8. 2015
    ..released per cell are measured by asymmetric flow-field flow fractionation/multi-angle light scattering (A4F/MALS) for three thyroid cancer cell lines as a function of a treatment that inhibits MAPK signaling pathways in the ..
  90. doi Broadening of polymer chromatographic signals: Analysis, quantification and correction through effective diffusion coefficients
    Inmaculada Suárez
    Chemical and Energy Technology Department, ESCET, Universidad Rey Juan Carlos, c Tulipan s n, 28933 Mostoles, Madrid, Spain
    J Chromatogr A 1407:193-202. 2015
    ..Usually, gel permeation chromatography (GPC) and multi angle light scattering (MALS) are used for this determination, but GPC values are overestimated due to the dispersion introduced by the column ..
  91. doi Characterization of Capsular Polysaccharides and Their Glycoconjugates by Hydrodynamic Methods
    Stephen E Harding
    National Centre for Macromolecular Hydrodynamics, University of Nottingham, Sutton Bonington Campus, Sutton Bonington, LE12 5RD, UK
    Methods Mol Biol 1331:211-27. 2015
    ..analytical ultracentrifugation (SE AUC), size exclusion chromatography coupled to multi-angle light scattering (SEC-MALS), and capillary viscometry-intrinsic viscosity measurement...
  92. doi Multimethod approach for the detection and characterisation of food-grade synthetic amorphous silica nanoparticles
    Francisco Barahona
    European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Via E Fermi 2749, 21027 Ispra, VA, Italy
    J Chromatogr A 1432:92-100. 2016
    ..Dynamic Light Scattering (DLS), Multiangle Light Scattering (MALS), Asymmetric Flow-Field Flow Fractionation (AF4), Inductively Coupled Plasma Mass Spectrometry (ICPMS) and ..
  93. pmc Influence of In Vitro IL-2 or IL-15 Alone or in Combination with Hsp 70 Derived 14-Mer Peptide (TKD) on the Expression of NK Cell Activatory and Inhibitory Receptors on Peripheral Blood T Cells, B Cells and NKT Cells
    Ilona Hromadnikova
    Department of Molecular Biology and Cell Pathology, Third Faculty of Medicine, Charles University, Prague, Ruska 87, 10 000 Prague 10, Czech Republic
    PLoS ONE 11:e0151535. 2016
    ..with TKD peptide on the cell surface expression of CD94, NK cell activatory receptors (CD16, NK2D, NKG2C, NKp30, NKp44, NKp46, NKp80, KIR2DL4, DNAM-1 and LAMP1) and NK cell inhibitory receptors (NKG2A, KIR2DL2/L3, LIR1/ILT-2 ..
  94. doi Median arcuate ligament syndrome in athletes
    Jeffrey N Harr
    Department of Surgery, The George Washington University Medical Center, The George Washington University, 2150 Pennsylvania Ave, NW Suite 6B, Washington, DC, 20037, USA
    Surg Endosc 31:476. 2017
    ..a "cramp" or "stitch," but an uncommon, and often overlooked, etiology of ETAP is median arcuate ligament syndrome (MALS)...
  95. pmc Mechanisms by Which Interleukin-12 Corrects Defective NK Cell Anticryptococcal Activity in HIV-Infected Patients
    Stephen K Kyei
    The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    MBio 7:. 2016
    ..killing and that interleukin-12 (IL-12) restores the activity at least partially through restoration of NKp30. However, the mechanisms causing this defect or how IL-12 restores the function was unknown...
  96. pmc Features of Memory-Like and PD-1(+) Human NK Cell Subsets
    Mariella Della Chiesa
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    Front Immunol 7:351. 2016
    ..identified fully mature NK cell subset, characterized by marked downregulation of the activating receptors NKp30 and NKp46 and by the unexpected expression of the inhibitory PD-1 receptor...
  97. pmc Acute median arcuate ligament syndrome after pancreaticoduodenectomy
    Ilhan Karabicak
    Department of Surgery, Kansai Medical University, 2 5 1, Shin Machi, Hirakata, Osaka, 573 1010, Japan
    Surg Case Rep 2:113. 2016
    Median arcuate ligament syndrome (MALS) has been reported in 2-7.6 % of patients undergoing pancreaticoduodenectomy (PD)...
  98. pmc Granule-Dependent Natural Killer Cell Cytotoxicity to Fungal Pathogens
    Henry Ogbomo
    The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada
    Front Immunol 7:692. 2016
    ..where multiple NK cell-activating receptors cooperate and signal events that mediate cytotoxicity, only the NKp30 receptor has been described to mediate signaling events that trigger the NK cell to mobilize its cytolytic payload ..
  99. pmc Altered expression of miR-181a and miR-146a does not change the expression of surface NCRs in human NK cells
    Mona Rady
    Microbiology and Immunology Department, German University in Cairo GUC, New Cairo, Egypt
    Sci Rep 7:41381. 2017
    ..in primary cultured human NK cells did not affect the level of expression of any of the three NCRs; NCR1, NCR2 or NCR3 or NK cell cytotoxicity...
  100. ncbi In vitro papillomavirus capsid assembly analyzed by light scattering
    Greg L Casini
    Section of Pediatric Hematology Oncology, University of Colorado School of Medicine, Denver, CO 80262, USA
    Virology 325:320-7. 2004
    ..coli and analyzed for the kinetics of in vitro capsid self-assembly using multi-angle light scattering (MALS). Pentamers self-assembled into capsid-like structures at a rate that was a function of protein concentration...

Research Grants16

  1. Mark D Sutton; Fiscal Year: 2016
    ..2, we will use small angle X-ray scattering (SAXS), size exclusion chromatography-multi angle light scattering (SEC-MALS), molecular modeling, and biochemical approaches to structurally define complexes consisting of the 5 different E...
  2. Static and dynamic light scattering instrumentation for macromolecular characteri
    Brian R Crane; Fiscal Year: 2010
    ..The instrumentation will consist of a Wyatt Technology Corporation DAWN HELEOS MALS (Multi-angle static light scattering) system, a WyattQELS (Quasi-Elastic-Light-Scattering, i.e...
  3. Expanding Data Collection Via High-Throughput DNA Sequencing
    Stephan C Schuster; Fiscal Year: 2010
    ..handle highly multiplexed samples in a single run makes Illumina GA IIx ideal for ChIP-seq of large genomes (mam- mals) and massively parallel sampling of small genomes (yeast)...
  4. Ov D Slayden; Fiscal Year: 2014
    ..Fertility will be assessed by mating the animals with fertile mals. Pelvic ultrasound and contrast enhanced ultrasound imaging will be used to characterize the effects of induced ..
  5. Roy A Mariuzza; Fiscal Year: 2014
    ..m157) for Ly49s, and the identification of novel, non-MHC ligands for the orphan NK receptors KLRG1, NKp80, and NKp30. We propose to establish the structural basis for each of these newly discovered NK receptor-ligand interactions ..
  6. Anthracycline cardiotoxicity and calsequestrin function
    SUSAN SHADLE; Fiscal Year: 2002
    ..behavior of calsequestrin using flow-field flow fractionation and multi-angle light scattering detection (flow-FFF/MALS); 3) to probe the ability of anthracyclines to inhibit calcium binding to calsequestrin using Ca-45 competitive ..
  7. NK Cell Interactions in Transplantation
    SHERI KRAMS; Fiscal Year: 2005
    ..the precise nature of the NK cell interaction with DC, there is evidence to suggest that the NK cell receptor NKp30 is important. We have recently cloned and characterized the rat homologue of NKp30...
  8. Synaptic signaling regulated by MALS family PDZ proteins
    Roger Nicoll; Fiscal Year: 2008
    ..In mammals, close homologues of LIN-2 (CASK), LIN-7 (MALS/Veli) and LIN-10 (Mint/X11) have all been identified and the LIN-2/-7/-10 complex occurs at highest levels at pre- ..
  9. AGING EFFECTS ON INTERMITTENT WORK CAPACITY
    Maury Nussbaum; Fiscal Year: 2002
    ..The quantification of intermittent work capacity is an important first step towards effective risk assessment, job evaluation, and reduction of economic and medical costs associated with workplace injuries. ..
  10. Facilitating Cells for Fetal Hematopoietic Transplant
    Laurence Shields; Fiscal Year: 2005
    ..Future directions will be towards the use of this model to explore the role and function of developmentally regulated adhesion molecules and their receptors as they relate to fetal hematopoietic transplantation. ..
  11. Risk factors and controls for falls from heights
    Maury Nussbaum; Fiscal Year: 2006
    ..abstract_text> ..
  12. Anergizing effect of NK cell receptor expression on HIV-specific CD8+ T cells
    Galit Alter; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. TARGETED DRUG THERAPY FOR LGL LEUKEMIA
    Pearlie K Epling Burnette; Fiscal Year: 2008
    ..Results of these studies should identify important molecular targets for drug development in bone marrow failure syndromes. ..
  14. The role of NK cells in human M. Tuberculosis infection
    Ramakrishna Vankayalapati; Fiscal Year: 2009
    ..These findings will facilitate development of immunomodulatory strategies to boost the immune response to M. tuberculosis, including multidrug-resistant tuberculosis. ..
  15. Occupational Trunk Flexion and Neuromuscular Disturbance
    Maury A Nussbaum; Fiscal Year: 2010
    ..Results will guide future studies and/or epidemiologic investigations regarding the mechanism of cumulative risk from flexed working postures. ..