NCAM2

Summary

Gene Symbol: NCAM2
Description: neural cell adhesion molecule 2
Alias: NCAM21, neural cell adhesion molecule 2, N-CAM-2, NCAM-2
Species: human

Top Publications

  1. ncbi Cloning of a novel human neural cell adhesion molecule gene (NCAM2) that maps to chromosome region 21q21 and is potentially involved in Down syndrome
    A Paoloni-Giacobino
    Department of Genetics and Microbiology, Geneva University Medical School, Switzerland
    Genomics 43:43-51. 1997
  2. ncbi Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues
    Gerold Schmitt-Ulms
    Institute for Neurodegenerative Disease, San Francisco, California 94143, USA
    Nat Biotechnol 22:724-31. 2004
  3. ncbi Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1
    Jason S Carroll
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Cell 122:33-43. 2005
  4. doi Whole-genome sequencing reveals the mutational landscape of metastatic small-cell gallbladder neuroendocrine carcinoma (GB-SCNEC)
    Maolan Li
    Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China Institute of Biliary Tract Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China
    Cancer Lett . 2016
  5. pmc Comparison of gene and protein expressions in rats residing in standard cages with those having access to an exercise wheel
    Helaine M Alessio
    Department of Kinesiology and Health, Miami University, Oxford, OH 45056, USA
    Biomed Res Int 2014:950516. 2014
  6. pmc Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families
    Manav Kapoor
    Washington University School of Medicine, United States
    Drug Alcohol Depend 142:56-62. 2014
  7. pmc 5' isomiR variation is of functional and evolutionary importance
    Geok Chin Tan
    Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College London, Du Cane Road, London W12 ONN, UK National University of Malaysia, Kuala Lumpur, Malaysia
    Nucleic Acids Res 42:9424-35. 2014
  8. pmc Identifying rare variants for genetic risk through a combined pedigree and phenotype approach: application to suicide and asthma
    T M Darlington
    Department of Psychiatry, University of Utah, Salt Lake City, UT, USA
    Transl Psychiatry 4:e471. 2014
  9. doi 21q21 deletion involving NCAM2: report of 3 cases with neurodevelopmental disorders
    Florence Petit
    Service de génétique clinique, Hopital Jeanne de Flandre, CHRU Lille, France Université Lille Nord de France, Lille, France Electronic address
    Eur J Med Genet 58:44-6. 2015
  10. doi Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels
    Lifu Sheng
    School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, 2052 New South Wales, Australia
    J Neurosci 35:1739-52. 2015

Scientific Experts

  • Florence Petit
  • Malene Winther
  • Gerold Schmitt-Ulms
  • Iryna Leshchyns'ka
  • Nikolaj Kulahin
  • Kim K Rasmussen
  • Brandon Luke L Seagle
  • Karen Y Niederhoffer
  • Caroline Scholz
  • Jingwen Zhao
  • Maolan Li
  • Silvia von der Heyde
  • Lifu Sheng
  • Vladimir Sytnyk
  • Loic Deleyrolle
  • Helaine M Alessio
  • Geok Chin Tan
  • T M Darlington
  • Robim M Rodrigues
  • Manav Kapoor
  • Yoshihiro Yoshihara
  • Je Seon Song
  • Melanie Langhauser
  • Mi Ran Choi
  • Shu Takahashi
  • Kai Wang
  • Jeremy C McIntyre
  • Mattias Alenius
  • Chad R Haldeman-Englert
  • Mi Ryung Han
  • Elisabeth Bock
  • Vladimir Berezin
  • Peter S Walmod
  • Jette S Kastrup
  • Michael Gajhede
  • Ole Kristensen
  • Tammy L Romanuik
  • Ryo Kimura
  • Erik A Nelson
  • Wei Li
  • X Shirley Liu
  • Umashankar Singh
  • S Edwards
  • Jason S Carroll
  • Jennifer T Cronkhite
  • Asa Kolterud
  • Paul R Buckland
  • Staffan Bohm
  • Patrice Eydoux
  • Monica Dandapani
  • Doris Steinemann
  • Mine Arslan-Kirchner
  • R Jeffrey Karnes
  • John Mawson
  • Tieliang Ma
  • Thomas Illig
  • Xiangsong Wu
  • Lin Jiang
  • Madeleine Mälzer
  • HaiBin Liang
  • Yun Zhang
  • Manfred Stuhrmann
  • Shohreh Shahabi
  • Manish Kohli
  • Yijian Zhang
  • Yingbin Liu
  • Gen Nishimura
  • Mandy Roy
  • Haojie Huang
  • Yu Zhao
  • Huaifeng Li
  • Robert Samuelson
  • Shanshan Xiang
  • Fatao Liu
  • Shibo Liu
  • Kai Zhang
  • Wenguang Wu
  • Wei Gong
  • Liguo Wang
  • Judy Y Yeh
  • Jun Zhang
  • Fei Zhang
  • Yunping Hu
  • Somayyeh Fahiminiya
  • Yun Liu
  • Xu an Wang
  • Jorg Schmidtke
  • Emily Schiller
  • Kevin H Eng
  • Loydie A Jerome-Majewska

Detail Information

Publications41

  1. ncbi Cloning of a novel human neural cell adhesion molecule gene (NCAM2) that maps to chromosome region 21q21 and is potentially involved in Down syndrome
    A Paoloni-Giacobino
    Department of Genetics and Microbiology, Geneva University Medical School, Switzerland
    Genomics 43:43-51. 1997
    ..The predicted polypeptide of this novel NCAM2 gene contains 837 amino acids and shows 62% similarity to the NCAM homologs...
  2. ncbi Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues
    Gerold Schmitt-Ulms
    Institute for Neurodegenerative Disease, San Francisco, California 94143, USA
    Nat Biotechnol 22:724-31. 2004
    ..Many of these proteins have been implicated in cell adhesion/neuritic outgrowth, and harbor immunoglobulin C2 and fibronectin type III-like motifs...
  3. ncbi Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1
    Jason S Carroll
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Cell 122:33-43. 2005
    ..Furthermore, knockdown of FoxA1 expression blocks the association of ER with chromatin and estrogen-induced gene expression demonstrating the necessity of FoxA1 in mediating an estrogen response in breast cancer cells...
  4. doi Whole-genome sequencing reveals the mutational landscape of metastatic small-cell gallbladder neuroendocrine carcinoma (GB-SCNEC)
    Maolan Li
    Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China Institute of Biliary Tract Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China
    Cancer Lett . 2016
    ..Two gene fusions, NCAM2-SGCZ and BTG3-CCDC40 were also discovered and validated by Sanger sequencing...
  5. pmc Comparison of gene and protein expressions in rats residing in standard cages with those having access to an exercise wheel
    Helaine M Alessio
    Department of Kinesiology and Health, Miami University, Oxford, OH 45056, USA
    Biomed Res Int 2014:950516. 2014
    ..In SED, ten unique DEGs occurred with age; three had cell adhesion functions (fn1, lgals3, ncam2)...
  6. pmc Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families
    Manav Kapoor
    Washington University School of Medicine, United States
    Drug Alcohol Depend 142:56-62. 2014
    ..The present study evaluated whether single nucleotide polymorphisms (SNPs) can influence the age at onset of AD in large high-risk families from the Collaborative Study on the Genetics of Alcoholism (COGA)...
  7. pmc 5' isomiR variation is of functional and evolutionary importance
    Geok Chin Tan
    Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College London, Du Cane Road, London W12 ONN, UK National University of Malaysia, Kuala Lumpur, Malaysia
    Nucleic Acids Res 42:9424-35. 2014
    ..and in support of this we report that a 5' isomiR-9-1 gained the ability to inhibit the expression of DNMT3B and NCAM2 but lost the ability to inhibit CDH1 in vitro. This result was confirmed by the use of isomiR-specific sponges...
  8. pmc Identifying rare variants for genetic risk through a combined pedigree and phenotype approach: application to suicide and asthma
    T M Darlington
    Department of Psychiatry, University of Utah, Salt Lake City, UT, USA
    Transl Psychiatry 4:e471. 2014
    ..factor (BDNF), neutral sphingomyelinase 2 (SMPD2), homeobox b2 (HOXB2), neural cell adhesion molecule (NCAM2), heterogeneous nuclear ribonucleoprotein A0 (HNRNPA0)), inflammation (free fatty acid receptor 2 (FFAR2)) and ..
  9. doi 21q21 deletion involving NCAM2: report of 3 cases with neurodevelopmental disorders
    Florence Petit
    Service de génétique clinique, Hopital Jeanne de Flandre, CHRU Lille, France Université Lille Nord de France, Lille, France Electronic address
    Eur J Med Genet 58:44-6. 2015
    Here we report three patients affected with neurodevelopmental disorders and harbouring 21q21 deletions involving NCAM2 gene...
  10. doi Neural cell adhesion molecule 2 promotes the formation of filopodia and neurite branching by inducing submembrane increases in Ca2+ levels
    Lifu Sheng
    School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, 2052 New South Wales, Australia
    J Neurosci 35:1739-52. 2015
    Changes in expression of the neural cell adhesion molecule 2 (NCAM2) have been proposed to contribute to neurodevelopmental disorders in humans. The role of NCAM2 in neuronal differentiation remains, however, poorly understood...
  11. pmc mRNA profiling reveals determinants of trastuzumab efficiency in HER2-positive breast cancer
    Silvia von der Heyde
    Statistical Bioinformatics, Department of Medical Statistics, University Medical Center Gottingen, Gottingen, Germany IndivuTest GmbH, Hamburg, Germany
    PLoS ONE 10:e0117818. 2015
    ..GDF15, IL8, LCN2, PTGS2 and 20 other genes were significantly higher expressed in HCC1954 than in BT474, while NCAM2, COLEC12, AFF3, TFF3, NRCAM, GREB1 and TFF1 were significantly lower expressed...
  12. pmc OCAM regulates embryonic spinal cord stem cell proliferation by modulating ErbB2 receptor
    Loic Deleyrolle
    Department of Neurosurgery, College of Medicine, University of Florida Gainesville, Gainesville, Florida, United States of America
    PLoS ONE 10:e0122337. 2015
    ..Here we report the expression of the olfactory cell adhesion molecule (OCAM/NCAM2/RNCAM) during mouse spinal cord development and in neural stem cells cultured as neurospheres...
  13. pmc Aβ-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease
    Iryna Leshchyns'ka
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia
    Nat Commun 6:8836. 2015
    ..We show that the neural cell adhesion molecule 2 (NCAM2) is enriched in synapses in the human hippocampus...
  14. pmc Discovery of candidate tumor biomarkers for treatment with intraperitoneal chemotherapy for ovarian cancer
    Brandon Luke L Seagle
    Department of Obstetrics, Gynecology and Reproductive Sciences, Western Connecticut Health Network, Danbury, CT, U S A
    Sci Rep 6:21591. 2016
    ..43 (0.28-0.66), p = 0.0001) and OS (49.6 vs 38.2 months, HR 0.46 (0.25-0.83), p = 0.01). Increased expression of NCAM2 and TSHR and decreased expression of GCNT1 was associated with decreased PFS and OS after IV chemotherapy (p < ..
  15. pmc Alterations of androgen receptor-regulated enhancer RNAs (eRNAs) contribute to enzalutamide resistance in castration-resistant prostate cancer
    Jingwen Zhao
    Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin 130021, China
    Oncotarget 7:38551-38565. 2016
    ..Expression of AR-eRNAs and related mRNAs in the loci of FTO, LUZP2, MARC1 and NCAM2 were further verified by real-time RT-PCR...
  16. doi Diagnosis of Van den Ende-Gupta syndrome: Approach to the Marden-Walker-like spectrum of disorders
    Karen Y Niederhoffer
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Med Genet A 170:2310-21. 2016
    ..L870V) in SCARF2 and predicted damaging mutations in several genes, most notably DGCR2 (p.P75L) and NCAM2 (p.S147G), both possible candidates for this child's intellectual disability...
  17. doi NCAM2 deletion in a boy with macrocephaly and autism: Cause, association or predisposition?
    Caroline Scholz
    Institute of Human Genetics, Hannover Medical School, Hannover, Germany Electronic address
    Eur J Med Genet 59:493-8. 2016
    ..problems, disturbed sleep and macrosomia including macrocephaly carrying a microdeletion that contains the entire NCAM2 gene and no other functional genes...
  18. ncbi Male and female germline specific expression of an EGFP reporter gene in a unique strain of transgenic rats
    Jennifer T Cronkhite
    Cecil H and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9038, USA
    Dev Biol 284:171-83. 2005
    ..FISH was used to localize the transgene insertion to chromosome 11q11-q12, proximal to Grik1 and near Ncam2. Analysis of the region did not identify known germ cell-specific genes but did identify 19 ESTs or transcribed ..
  19. ncbi A high proportion of chromosome 21 promoter polymorphisms influence transcriptional activity
    Paul R Buckland
    Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK
    Gene Expr 11:233-9. 2004
    ..The functional variants were distributed across the promoters of CRYAA, IFNAR1, KCNJ15, NCAM2, IGSF5, and B3GALT5...
  20. pmc Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals
    Robim M Rodrigues
    1 Department of Toxicology, Center for Pharmaceutical Research, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel VUB, Brussels, Belgium
    Stem Cells Dev 23:44-55. 2014
    ..hSKP [hSKP-derived hepatic progenitor cells (hSKP-HPC)] express hepatic progenitor cell markers (EPCAM, NCAM2, PROM1) and adult hepatocyte markers (ALB), as well as key biotransformation enzymes (CYP1B1, FMO1, GSTA4, GSTM3) ..
  21. pmc Comparative gene expression analysis of the human periodontal ligament in deciduous and permanent teeth
    Je Seon Song
    Department of Pediatric Dentistry, College of Dentistry, Yonsei University, Seoul, Korea
    PLoS ONE 8:e61231. 2013
    ..tissue degradation (IL6 and ADAMTS18), myocontraction (PDE3B, CASQ2, and MYH10), and neurological responses (FOS, NCAM2, SYT1, SLC22A3, DOCK3, LRRTM1, LRRTM3, PRSS12, and ARPP21)...
  22. doi NCAM2/OCAM/RNCAM: cell adhesion molecule with a role in neuronal compartmentalization
    Malene Winther
    Protein Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Panum Institute, Blegdamsvej 3C, Building 24 2, 2200 Copenhagen N, DK, Denmark
    Int J Biochem Cell Biol 44:441-6. 2012
    Neural cell adhesion molecules 2 (NCAM2/OCAM/RNCAM), is a paralog of NCAM1...
  23. doi Neural cell adhesion molecule 2 as a target molecule for prostate and breast cancer gene therapy
    Shu Takahashi
    Department of Molecular Medicine, Sapporo Medical University, Sapporo, Japan
    Cancer Sci 102:808-14. 2011
    ..It was identified as neural cell adhesion molecule 2 (NCAM2)...
  24. doi Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping
    Kim K Rasmussen
    Protein Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen, Denmark
    J Mol Biol 382:1113-20. 2008
    The crystal structure of the first immunoglobulin (Ig1) domain of neural cell adhesion molecule 2 (NCAM2/OCAM/RNCAM) is presented at a resolution of 2.7 A...
  25. ncbi A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2
    H Gomyo
    Radiobiology Division, Oncogene Division, Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Genomics 62:139-46. 1999
    ..It shares strong homology with mouse IGSF-B12 and cell adhesion molecules NCAM1 and NCAM2 within their Ig-like C2-type domains...
  26. ncbi Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome
    E C Akeson
    The Jackson Laboratory, Bar Harbor ME 04609, USA
    Cytogenet Cell Genet 93:270-6. 2001
    ..marker chromosome contains a small portion of Chr 17 euchromatin, that the Chr 16 breakpoint lies between the Ncam2 and Gabpa/App genes, and that the Ts65Dn chromosome contains >80% of the human Chr 21 homologs...
  27. ncbi Differential function of RNCAM isoforms in precise target selection of olfactory sensory neurons
    Mattias Alenius
    Department of Molecular Biology, Umea University, Umea, S 901 87, Sweden
    Development 130:917-27. 2003
    ..RNCAM (OCAM, NCAM2) is assumed to regulate a broad zonal segregation of projections by virtue of being a homophilic cell adhesion ..
  28. ncbi The Lim homeobox gene Lhx2 is required for olfactory sensory neuron identity
    Asa Kolterud
    Department of Molecular Biology, Umea University, Umea, SE901 87, Sweden
    Development 131:5319-26. 2004
    ..not diversify into subpopulations expressing different OR genes and other region-restricted genes such as Nqo1 and Ncam2. Lhx2-/- embryos have, however, a normal distribution of Mash1-positive and neurogenin 1-positive neuronal ..
  29. pmc Expression analysis onto microarrays of randomly selected cDNA clones highlights HOXB13 as a marker of human prostate cancer
    S Edwards
    Section of Molecular Carcinogenesis, Male Urological Cancer Research Centre, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK
    Br J Cancer 92:376-81. 2005
    ..genes through interrogation of SAGE databases, a further three genes from our clone set, HOXB13, SPON2 and NCAM2, emerged as additional candidate markers of human prostate cancer...
  30. ncbi Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1
    Umashankar Singh
    Department of Development and Genetics, Evolutionary Biology Center, Uppsala University, Sweden
    Dev Dyn 234:1034-45. 2005
    ..However, expression analysis of Car3 and Ncam2, which can take over the function of Car2 and Ncam1, respectively, indicated a possible rescue mechanism, as Car3 ..
  31. pmc Identification of human STAT5-dependent gene regulatory elements based on interspecies homology
    Erik A Nelson
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:26216-24. 2006
    ..We identified four such regions, including one with tandem STAT5 binding sites in the first intron of the NCAM2 gene...
  32. ncbi The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease
    Ryo Kimura
    Department of Psychiatry, Osaka University Graduate School of Medicine, 2 2 D3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Hum Mol Genet 16:15-23. 2007
    ..dose supported genetic risk of 17 markers, of which eight markers were linked to the SAMSN1, PRSS7, NCAM2, RUNX1, DYRK1A and KCNJ6 genes...
  33. doi Ncam1a and Ncam1b: two carriers of polysialic acid with different functions in the developing zebrafish nervous system
    Melanie Langhauser
    Zoologisches Institut, Abteilung für Zell und Neurobiologie, Karlsruhe Institute of Technology KIT, Haid und Neu Strasse 9, Karlsruhe, Germany
    Glycobiology 22:196-209. 2012
    ..Phylogenetic analyses reveal the presence of two related gene clusters, NCAM1 and NCAM2, in tetrapods and fishes...
  34. pmc Novel biomarkers for prostate cancer including noncoding transcripts
    Tammy L Romanuik
    Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, Canada
    Am J Pathol 175:2264-76. 2009
    ..100 kb) from mRNA AK000023), POP2 (4 kb from mRNA AL832227), POP3 (50 kb from EST CFI40309), POP5 (intron of NCAM2, accession DO668384), POP6 (intron of FHIT), POP7 (intron of TNFAIP8), POP8 (intron of EFNA5), POP9 (intron of ..
  35. pmc A de novo 8.8-Mb deletion of 21q21.1-q21.3 in an autistic male with a complex rearrangement involving chromosomes 6, 10, and 21
    Chad R Haldeman-Englert
    Division of Human Genetics, The Children s Hospital of Philadelphia, 1002 ARC, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Am J Med Genet A 152:196-202. 2010
    ..The deletion involves 19 genes, including NCAM2 and GRIK1, both of which are associated with normal brain development and function, and have been considered as ..
  36. doi Ethanol-induced small heat shock protein genes in the differentiation of mouse embryonic neural stem cells
    Mi Ran Choi
    Division of Molecular and Life Sciences, Hanyang University, Ansan 426 791, Republic of Korea
    Arch Toxicol 85:293-304. 2011
    ..including Ctnna1, Wnt5a, Wnt5b, Wnt7a, Fzd3, and Fzd2; genes related to cell adhesion, including Cadm1, Ncam1, and Ncam2; and genes encoding small heat shock proteins, including HspB2, HspB7, and HspB8...
  37. pmc Axon growth and guidance genes identify nascent, immature, and mature olfactory sensory neurons
    Jeremy C McIntyre
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Neurosci Res 88:3243-56. 2010
    ..Cell adhesion molecules were expressed either by both immature and mature OSNs (Dscam, Ncam1, Ncam2, Nrxn1) or solely by immature OSNs (Chl1, Nfasc1, Dscaml1)...
  38. pmc Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study
    Mi Ryung Han
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMC Neurol 10:90. 2010
    ..We carried out a genome-wide association study (GWAS) in order to better define the genetic backgrounds to these three states in relation to CSF levels...
  39. doi Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule
    Nikolaj Kulahin
    Protein Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Structure 19:203-11. 2011
    The ectodomain of olfactory cell adhesion molecule (OCAM/NCAM2/RNCAM) consists of five immunoglobulin (Ig) domains (IgI-V), followed by two fibronectin-type 3 (Fn3) domains (Fn3I-II)...
  40. pmc A genome-wide association study on obesity and obesity-related traits
    Kai Wang
    Center for Applied Genomics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e18939. 2011
    ..67 × 10(-9)), previously associated with body weight and fat distribution. Our study demonstrated how a relatively small sample ascertained through extreme phenotypes can detect genuine associations in a GWAS...