NAT6

Summary

Gene Symbol: NAT6
Description: N-acetyltransferase 6
Alias: FUS-2, FUS2, N-acetyltransferase 6, N-acetyltransferase 6 (GCN5-related), protein fusion-2
Species: human

Top Publications

  1. ncbi The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium
    M I Lerman
    Laboratory of Immanobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
    Cancer Res 60:6116-33. 2000
  2. ncbi Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas
    Paulisally Hau Yi Lo
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, People s Republic of China
    Cancer Lett 234:184-92. 2006
  3. ncbi Familial partial monosomy 7 and myelodysplasia: different parental origin of the monosomy 7 suggests action of a mutator gene
    A Minelli
    Biologia Generale e Genetica Medica, , C.P. 217, I 27100, Pavia, Italy
    Cancer Genet Cytogenet 124:147-51. 2001
  4. ncbi [Detailed mapping and clinical significance of loss of heterozygosity on 9p13-23 in laryngeal squamous cell carcinoma by microsatellite analysis]
    Xian fa Xu
    Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing, PR China
    Ai Zheng 22:452-7. 2003
  5. ncbi Transcriptional repression mediated by the WT1 Wilms tumor gene product
    S L Madden
    Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104
    Science 253:1550-3. 1991
  6. pmc Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein
    Hansoo Lee
    Department of Pathology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Mol Cell Biol 27:2103-19. 2007
  7. ncbi Allelotyping in mycosis fungoides and Sézary syndrome: common regions of allelic loss identified on 9p, 10q, and 17p
    J J Scarisbrick
    Skin Tumour Unit, St John s Institute Dermatology, St Thomas Hospital, London, UK
    J Invest Dermatol 117:663-70. 2001
  8. ncbi ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways
    Michele A Battle
    Carcinogenesis Laboratory, Cell and Molecular Biology Program, Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 1302, USA
    Biochemistry 42:7270-82. 2003
  9. pmc Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis
    Timothy A Chan
    Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America
    PLoS Med 5:e114. 2008
  10. ncbi mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells
    Li Hui
    Department of Biological Sciences, Hunter College of the City University of New York, New York, New York 10021, USA
    J Biol Chem 280:35829-35. 2005

Research Grants

  1. Michael A Caligiuri; Fiscal Year: 2014
  2. MOLECULAR PROGRESSION MODEL FOR HNSCC
    David Sidransky; Fiscal Year: 2012
  3. TUMOR SUPPRESSOR GENES IN HUMAN THYROID NEOPLASMS
    James Fagin; Fiscal Year: 1990
  4. ISOLATION OF TUMOR SUPPRESSOR GENES IN RHABDOMYOSARCOMA
    Mary Sugrue; Fiscal Year: 2000
  5. ALLELE LOSS IN THE GENESIS OF GASTRIC CANCER
    Barbara Schneider; Fiscal Year: 1999
  6. Characterization of Human 3p Recessive Oncogenes
    John Minna; Fiscal Year: 2004
  7. Detection of Novel Gene Defects in Basal Cell Carcinoma
    Steven Fakharzadeh; Fiscal Year: 2005
  8. Use of RNAi to investigate cullin-5 function in breast cancer
    Michael Fay; Fiscal Year: 2006
  9. STATISTICAL METHODS FOR MOLECULAR CANCER DATA
    Michael Newton; Fiscal Year: 1999
  10. SIGNIFICANCE OF ALLELIC DELETIONS IN NEUROBLASTOMA
    John Maris; Fiscal Year: 1999

Detail Information

Publications319 found, 100 shown here

  1. ncbi The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium
    M I Lerman
    Laboratory of Immanobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
    Cancer Res 60:6116-33. 2000
    ..of the genes to have two or more amino acid sequence-altering mutations including BLU, NPRL2/Gene21, FUS1, HYAL1, FUS2, and SEMA3B...
  2. ncbi Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas
    Paulisally Hau Yi Lo
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, People s Republic of China
    Cancer Lett 234:184-92. 2006
    The expression of six chromosome 3p21.3 candidate tumor suppressor genes (BLU, FUS2, HYAL2, NPRL2, RASSF1A, and SEMA3B) in esophageal squamous cell carcinoma (ESCC) has been investigated...
  3. ncbi Familial partial monosomy 7 and myelodysplasia: different parental origin of the monosomy 7 suggests action of a mutator gene
    A Minelli
    Biologia Generale e Genetica Medica, , C.P. 217, I 27100, Pavia, Italy
    Cancer Genet Cytogenet 124:147-51. 2001
    ..We postulate that, in fact, an inherited mutation in any of a group of mutator genes causes familial monosomy 7 also in the absence of a recognized mendelian disease, and that marrow chromosome 7 anomalies, in turn, lead to MDS/AML...
  4. ncbi [Detailed mapping and clinical significance of loss of heterozygosity on 9p13-23 in laryngeal squamous cell carcinoma by microsatellite analysis]
    Xian fa Xu
    Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing, PR China
    Ai Zheng 22:452-7. 2003
    ..This study was designed to refine the hot spots of LOH on 9p13-23 in laryngeal squamous cell carcinoma and compare the correlation between the incidence of microsatellite LOH and the clinicopathological parameters...
  5. ncbi Transcriptional repression mediated by the WT1 Wilms tumor gene product
    S L Madden
    Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104
    Science 253:1550-3. 1991
    ..The repression function was mapped to the glutamine- and proline-rich NH2-terminus of WT1; fusion of this domain to the zinc finger region of EGR-1 converted EGR-1 into a transcriptional repressor...
  6. pmc Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein
    Hansoo Lee
    Department of Pathology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Mol Cell Biol 27:2103-19. 2007
    ..Collectively, these findings indicate that NGB is a tumor suppressor that regulates and requires merlin to suppress cell proliferation...
  7. ncbi Allelotyping in mycosis fungoides and Sézary syndrome: common regions of allelic loss identified on 9p, 10q, and 17p
    J J Scarisbrick
    Skin Tumour Unit, St John s Institute Dermatology, St Thomas Hospital, London, UK
    J Invest Dermatol 117:663-70. 2001
    ..These results provide the basis for further studies defining more accurately chromosomal regions of deletions and candidate tumor suppressor genes involved in mycosis fungoides and Sézary syndrome...
  8. ncbi ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways
    Michele A Battle
    Carcinogenesis Laboratory, Cell and Molecular Biology Program, Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 1302, USA
    Biochemistry 42:7270-82. 2003
    ..Clearly, ST7 is an LRP, and therefore, it should now be referred to as LRP12...
  9. pmc Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis
    Timothy A Chan
    Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America
    PLoS Med 5:e114. 2008
    ..We hypothesize that key tumor suppressor genes in cancer may be subject to mutation or hypermethylation...
  10. ncbi mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells
    Li Hui
    Department of Biological Sciences, Hunter College of the City University of New York, New York, New York 10021, USA
    J Biol Chem 280:35829-35. 2005
    ..The ability of phospholipase D to suppress protein phosphatase 2A identifies a critical target of an emerging phospholipase D/mTOR survival pathway in the transformation of human cells...
  11. pmc Fus2 localizes near the site of cell fusion and is required for both cell fusion and nuclear alignment during zygote formation
    E A Elion
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Cell Biol 130:1283-96. 1995
    ..Genetic evidence suggests that the FUS2 gene product promotes cell fusion during zygote formation in Saccharomyces cerevisiae, functioning with the Fus1 ..
  12. ncbi A retinoic acid receptor beta/gamma-selective prodrug (tazarotene) plus a retinoid X receptor ligand induces extracellular signal-regulated kinase activation, retinoblastoma hypophosphorylation, G0 arrest, and cell differentiation
    Andrew Yen
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Mol Pharmacol 66:1727-37. 2004
    ..Tazarotene used with RXR-selective ligand may thus be a useful antineoplastic agent in differentiation induction therapy as exemplified by the prototypical RA treatment of acute promyelocytic leukemia...
  13. pmc Merlin knockdown in human Schwann cells: clues to vestibular schwannoma tumorigenesis
    Zana Ahmad
    Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of California San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, U S A
    Otol Neurotol 31:460-6. 2010
    ..To investigate the early events in molecular progression toward schwannoma tumorigenesis, we developed an in vitro model of human Schwann cell tumorigenesis by merlin knockdown...
  14. ncbi Frequent loss of heterozygosity at the 19p13.3 locus without LKB1/STK11 mutations in human carcinoma metastases to the brain
    S B Sobottka
    Department of Neurosurgery, Technical University of Dresden, Germany
    J Neurooncol 49:187-95. 2000
    ..Based on these findings, the genes adjacent to LKB1/STK11 may be relevant for the development of metastases to the brain from certain carcinomas...
  15. ncbi Frequent occurrence of Ha-rasl allelic deletion in human ovarian adenocarcinomas
    A Viel
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano, Pordenone, Italy
    Tumori 77:16-20. 1991
    ..These findings may suggest that a putative tumor suppressor gene closely linked to Ha-rasl in 11p15.5 is involved in ovarian cancerogenesis...
  16. ncbi Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomas
    Javier Silva
    Department of Medical Oncology, Hospital Universitario Puerta de Hierro, c San Martin de Porres, E 28035 Madrid, Spain
    Mutat Res 594:78-85. 2006
    ..Future and larger series studies in different tumor types are necessary to clarify Ris-1 function in human cancer...
  17. ncbi Diminished levels of the putative tumor suppressor proteins EXT1 and EXT2 in exostosis chondrocytes
    M A Bernard
    Department of Pediatrics, University of Texas Houston Medical School, Houston, Texas 77225 0708, USA
    Cell Motil Cytoskeleton 48:149-62. 2001
    ..These results suggest that multiple mutational steps are involved in exostosis development and that EXT genes play a role in cell signaling related to chondrocyte cytoskeleton regulation...
  18. ncbi Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration
    Yonghe Li
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, Missouri 63110, USA
    J Biol Chem 277:42366-71. 2002
    ..Taken together, these results demonstrate that LRP1B can function as a negative regulator of uPAR regeneration and cell migration...
  19. ncbi The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production
    Judy A Cam
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:29639-46. 2004
    ..These findings reveal that LRP1B is a novel binding partner of APP that functions to decrease APP processing to Abeta. Consequently LRP1B expression could function to protect against the pathogenesis of Alzheimer's disease...
  20. ncbi Inhibition of growth by p205: a nuclear protein and putative tumor suppressor expressed during myeloid cell differentiation
    Jonathan M Dermott
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702 1201, USA
    Stem Cells 22:832-48. 2004
    ..We propose that during myelomonocytic cell differentiation, induction of p205 expression contributes to cell growth arrest, thus allowing progenitor cells to differentiate...
  21. ncbi Loss of heterozygosity on chromosome 22q in gastrointestinal stromal tumors (GISTs): a study on 50 cases
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Lab Invest 85:237-47. 2005
    ..An isolated LOH at D22S425 was equally found in both benign and malignant tumors. These observations may suggest that LOHs on chromosome 22q in GISTs play a role in early stages of tumor formation as well as in late tumor progression...
  22. pmc Microdissecting the genetic events in nephrogenic rests and Wilms' tumor development
    A K Charles
    Department of Pediatric Pathology, St Michael s Hospital, Bristol, United Kingdom
    Am J Pathol 153:991-1000. 1998
    ..Intralobar and perilobar nephrogenic rests are known to have different biological behaviors, and this study suggests that they are genetically different. A multistep model of Wilms' tumor pathogenesis is supported by these findings...
  23. ncbi Non-linkage of familial rhabdoid tumors to SMARCB1 implies a second locus for the rhabdoid tumor predisposition syndrome
    Michael C Frühwald
    University Children s Hospital Muenster, Department of Paediatric Haematology and Oncology, Muenster, Germany
    Pediatr Blood Cancer 47:273-8. 2006
    ..2. Several familial cases have been published and summarized under the term rhabdoid tumor predisposition syndrome. In all of the published familial cases, inactivation of SMARCB1 was detected in tumor tissues...
  24. pmc Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer
    Ruben Agrelo
    Cancer Epigenetics Laboratory, Spanish National Cancer Centre, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 103:8822-7. 2006
    ..These findings highlight the importance of WRN epigenetic inactivation in human cancer, leading to enhanced chromosomal instability and hypersensitivity to chemotherapeutic drugs...
  25. ncbi Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice
    R H Zurawel
    Department of Neurological Surgery, Mayo Clinic and Foundation, Rochester, Minnesota, USA
    Genes Chromosomes Cancer 28:77-81. 2000
    ..Expression of Gli1 was increased in tumors compared to normal cerebellum. These results suggest that deletion of one copy of Ptch may be sufficient to promote medulloblastoma development in mice...
  26. ncbi Genetic analysis of childhood germ cell tumors with comparative genomic hybridization
    D T Schneider
    Clinic of Pediatric Hematology and Oncology, Heinrich Heine University, Medical Center, Dusseldorf, Germany
    Klin Padiatr 213:204-11. 2001
    ..As CGH does not require tissue culture, it also allows analysing archival tissue samples...
  27. ncbi Low expression of reduced folate carrier-1 and folylpolyglutamate synthase correlates with lack of a deleted in colorectal carcinoma mRNA splice variant in normal-appearing mucosa of colorectal carcinoma patients
    Yvonne Wettergren
    Department of General Surgery, Sahlgrenska University Hospital Ostra, Goteborg University, S 416 85 Goteborg, Sweden
    Cancer Detect Prev 29:348-55. 2005
    ..The purpose of this study was to analyze if the folate level and the gene expression levels of reduced folate carrier (RFC-1) and folylpolyglutamate synthase (FPGS) had impact on the expression of DCC splice variants...
  28. pmc Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancer
    Chunling Yi
    Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 25:10052-9. 2005
    ..These findings indicate that the 4.1B gene is not required for normal development and that 4.1B/Dal-1 does not function as a tumor suppressor gene...
  29. pmc Antitumor effect of retinoic acid receptor-beta2 associated with suppression of cyclooxygenase-2
    Shumei Song
    Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Prev Res (Phila) 2:274-80. 2009
    ..Thus, further studies will determine whether manipulation of COX-2 expression in different cancers can antagonize RAR-beta2 activity...
  30. ncbi Genetic aberrations common in gastric high-grade large B-cell lymphoma
    P Starostik
    Institute of Pathology and Division of Medicine, Wuerzburg University, Wuerzburg, Germany
    Blood 95:1180-7. 2000
    ..Common genetic aberrations responsible for lymphomagenesis are deletions of 6q, loss of p53, and amplification of the 3q27 and the MLL gene regions. (Blood. 2000;95:1180-1187)..
  31. ncbi A dual-color FISH framework map for the characterization of the Sai1 tumor suppression region on rat chromosome 5
    K Helou
    CMB Genetics, Lundberg Laboratory, Goteborg University, Goteborg, Sweden
    Genes Chromosomes Cancer 27:362-72. 2000
    ..1) and Cd30lg (5q24.3). The framework map will provide the basis for the detailed physical YAC clone contig mapping of this region, and facilitate the identification and characterization of the Sai1 locus...
  32. ncbi Molecular genetic parameters in pathogenesis and prognosis of testicular germ cell tumors
    A Heidenreich
    Department of Urology, Philipps University, Marburg, Germany
    Eur Urol 37:121-35. 2000
    ..and prognosis of testicular germ cell tumors will not only help to better understand development and progression of testicular cancer, but it will also define new approaches to classification and management of germ cell tumors..
  33. ncbi 3p21, 5q21, 9p21 and 17p13.1 allelic deletions are potential markers of individuals with a high risk of developing adenocarcinoma in Barrett's epithelium without dysplasia
    Julian Sanz-Ortega
    Departamento de Anatomía Patológica Hospital Clinico San Carlos, Martin Lagos s n, Madrid, Spain 28040
    Hepatogastroenterology 50:404-7. 2003
    ..We investigated 32 cases of Barrett's esophagus with no evidence of dysplasia for LOH at 5q21 (APC), 3p21, 9p21 (p16) and 17p13.1 (p53) chromosomal regions...
  34. ncbi Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene
    Violetta Barbashina
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Clin Cancer Res 11:1119-28. 2005
    ..To better define the histologic correlates of different patterns of 1p and 19q loss, we evaluated 1p/19q status in a large group of gliomas. This also allowed us to define a very small minimal deleted region (MDR) on 1p36...
  35. doi Single nucleotide polymorphisms of IGFBP-3 gene and lung cancer risk in a Korean population
    Sle Gi Lo Han
    Genomic Research Center for Lung and Breast Ovarian Cancers, Korea University Anam Hospital, Seoul, Republic of Korea
    Lung Cancer 62:152-61. 2008
    ..These results suggest that IGFBP-3 promoter polymorphisms of -1590 C>A and -202 A>C might be a genetic risk factor for lung cancer by means of decreased IGFBP-3 expression among females or never-smoking Koreans...
  36. doi Assessment of NORE1A as a putative tumor suppressor in human neuroblastoma
    Janos Geli
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
    Int J Cancer 123:389-94. 2008
    ..Promotor methylation is not a common mechanism responsible for NORE1A transcriptional suppression in this tumor type...
  37. doi TCEAL7, a putative tumor suppressor gene, negatively regulates NF-kappaB pathway
    R Rattan
    Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA
    Oncogene 29:1362-73. 2010
    ....
  38. pmc Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation
    Franco Capozza
    Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Pathol 162:2029-39. 2003
    ..Our results provide the first genetic evidence that caveolin-1 indeed functions as a tumor suppressor gene in vivo...
  39. doi Hypoglycemia from IGF2 overexpression associated with activation of fetal promoters and loss of imprinting in a metastatic hemangiopericytoma
    Elizabeth A Lawson
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 94:2226-31. 2009
    ..The mechanism of IGF2 overexpression in non-islet-cell tumor hypoglycemia is not understood...
  40. ncbi A cell cycle regulator potentially involved in genesis of many tumor types
    A Kamb
    Myriad Genetics, Inc, Salt Lake City, UT 84108
    Science 264:436-40. 1994
    ..Melanoma cell lines that carried at least one copy of MTS1 frequently carried nonsense, missense, or frameshift mutations in the gene. These findings suggest that MTS1 mutations are involved in tumor formation in a wide range of tissues...
  41. ncbi Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues
    J V Rajan
    Department of Molecular and Cellular Engineering, University of Pennsylvania School of Medicine, Philadelphia 19104 6069, USA
    Dev Biol 184:385-401. 1997
    ..These observations suggest that the gender-specific differences in phenotype associated with germline mutations in BRCA2 versus BRCA1 may be related to the differential regulation of these genes by sex hormones...
  42. ncbi Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer
    K Ueno
    Department of Medicine III, Osaka University Medical School, Suita, Japan
    Hum Genet 102:63-8. 1998
    ..This large contig and expression map should prove crucial in the identification of susceptibility gene(s) related to the progression of lung cancer...
  43. ncbi Localization of a CDKN2 gene in linkage group V of Xiphophorus fishes defines it as a candidate for the DIFF tumor suppressor
    S Kazianis
    Department of Carcinogenesis, University of Texas M D Anderson Cancer Center, Smithville 78957 0389, USA
    Genes Chromosomes Cancer 22:210-20. 1998
    ....
  44. ncbi Keyhole limpet hemocyanin type 2 (KLH2): detection and immunolocalization of a labile functional unit h
    W Gebauer
    Institute of Zoology, University of Mainz, Mainz, D 55099, Germany
    J Struct Biol 128:280-6. 1999
    ..5, in the absence of divalent cations. Electron microscopic immunolocalization using a specific monoclonal antibody reveals that FU KLH2-h is located at the collar of the decamer...
  45. ncbi Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization and fluorescence in situ hybridization: an intergroup rhabdomyosarcoma study
    J A Bridge
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198 3135, USA
    Genes Chromosomes Cancer 27:337-44. 2000
    ..In summary, CGH and FISH analyses of 12 E-RMS specimens revealed novel genomic imbalances that may be useful in directing further molecular studies for the determination of E-RMS critically involved genes...
  46. ncbi Molecular analysis of the h-warts/LATS1 gene in human breast cancer
    N Morinaga
    Department of Surgery I, Faculty of Medicine, Gunma University, Maebashi, Gunma 371 8511, Japan
    Int J Oncol 17:1125-9. 2000
    ..Two polymorphisms were found, but neither of them caused amino acid substitutions. Further investigations are necessary to elucidate the role of the h-warts/LATS1 gene in the carcinogenesis of breast cancer...
  47. pmc Pooled analysis of loss of heterozygosity in breast cancer: a genome scan provides comparative evidence for multiple tumor suppressors and identifies novel candidate regions
    Brian J Miller
    College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA
    Am J Hum Genet 73:748-67. 2003
    ..Our approach provides a comparative framework for further investigation of regions exhibiting LOH and identifies broad genomic regions for which there exist few data...
  48. ncbi Allelic loss analysis of lymphomas induced in Fas-heterozygous deficient mice
    Shoji Ogawa
    Department of Veterinary Sciences, College of Agriculture, Osaka Prefecture University, 102 Gakuen cho, Sakai, Osaka 599 8570, Japan
    J Vet Med Sci 66:97-102. 2004
    ..Therefore, the putative tumor-suppressor gene regions responsible for lymphomagenesis might not considerably differ due to the Fas gene status...
  49. pmc Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induces loss of BACH2 expression
    Tetsuya Takakuwa
    Department of Pathology, Osaka University Graduate School of Medicine, Yamada oka, Suita, Osaka, Japan
    Am J Pathol 164:967-74. 2004
    ..BACH2 was not expressed in the Raji cell line. Because BACH2 is a putative tumor suppressor gene, loss of its expression through EBV integration might contribute to lymphomagenesis...
  50. ncbi Structural integrity and expression of the L3MBTL gene in normal and malignant hematopoietic cells
    Donal MacGrogan
    Laboratory of Molecular Aspects of Hematopoiesis, Sloan Kettering Institute, New York, New York 10021, USA
    Genes Chromosomes Cancer 41:203-13. 2004
    ..These data suggest that L3MBTL is not mutated in MDS or MPD. However, given the known dosage effects of PcG proteins in regulating gene expression, reduced or absent L3MBTL expression may be relevant in some cases of myeloid leukemia...
  51. ncbi Dickkopf-3/REIC functions as a suppressor gene of tumor growth
    Sen Yung Hsieh
    Liver Research Unit, Chang Gung Memorial Hospital, Tao Yuan, Taiwan
    Oncogene 23:9183-9. 2004
    ..In conclusion, these data indicate that Dkk-3/REIC functions as a suppressor for human tumor growth...
  52. pmc Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-beta
    O Cristina Micali
    Department of Plant Microbe Interactions, Max Planck Institute for Plant Breeding Research, Koeln, Germany
    BMC Cancer 7:52. 2007
    ..In this report, we investigated the role of basal xaf1 promoter methylation in xaf1 expression and assessed the responsiveness of cancer cell lines to XAF1 induction by IFN-beta...
  53. pmc Down-regulation of SFRP1 as a putative tumor suppressor gene can contribute to human hepatocellular carcinoma
    Jian Huang
    Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China
    BMC Cancer 7:126. 2007
    ..However, whether the down-regulation of SFRP1 can contribute to hepatocarcinogenesis still remains unclear...
  54. pmc 14-3-3gamma induces oncogenic transformation by stimulating MAP kinase and PI3K signaling
    Vijayababu M Radhakrishnan
    Arizona Cancer Center, Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 5:e11433. 2010
    ..Overall, our studies establish 14-3-3gamma as an oncogene and implicate MAPK and PI3K signaling as important for 14-3-3gamma induced transformation...
  55. pmc Epigenetic down-regulation of the tumor suppressor gene PRDM1/Blimp-1 in diffuse large B cell lymphomas: a potential role of the microRNA let-7
    Kui Nie
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA
    Am J Pathol 177:1470-9. 2010
    ..These findings provide further evidence for an important role of impairment of terminal B cell differentiation in DLBCL pathogenesis...
  56. pmc Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene
    Jianjun Zhang
    Department of Biochemistry and Molecular Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, People s Republic of China
    Cancer 117:86-95. 2011
    ..Tumor suppressor microRNA miR-145 is commonly down-regulated in colon carcinoma tissues, but its specific role in tumors remains unknown...
  57. pmc Clinicopathological significance of loss of ARID1A immunoreactivity in ovarian clear cell carcinoma
    Daichi Maeda
    Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan E Mails D M M F
    Int J Mol Sci 11:5120-8. 2010
    ....
  58. pmc Divergent control of Cav-1 expression in non-cancerous Li-Fraumeni syndrome and human cancer cell lines
    Zaki A Sherif
    Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, DC, USA
    Cancer Biol Ther 14:29-38. 2013
    ..Thus, there is a divergent control of Cav-1 expression as evidenced in non-cancerous Li-Fraumeni syndrome and some aggressive human cancer cell lines...
  59. ncbi Analysis of the Ten-Eleven Translocation 2 (TET2) gene mutation in myeloproliferative neoplasms
    Jung Sook Ha
    M D, Ph D Department of Laboratory Medicine, Keimyung University School of Medicine, 56 Dalsung ro, Jung Gu, Dongsan Dong, Daegu, Republic of Korea, 700 712 phone 82 53 250 7266 fax 82 53 250 7275 e mail
    Ann Clin Lab Sci 44:173-9. 2014
    ..19.6%, P=0.018). The TET2 mutation most likely contributes to clinical phenotypes and shows a high accompanying rate with JAK2 V617F; larger scale studies involving more MPN patients are needed. ..
  60. ncbi LPTS: A Novel Tumor Suppressor Gene and a Promising Drug Target for Cancer Intervention
    Li Baichuan
    Department of Histology and Embryology, Third Military Medical University, Chongqing 400038, P R China
    Recent Pat Anticancer Drug Discov 10:170-5. 2015
    ..Lpts gene is becoming a promising drug target for cancer intervention owing to its powerful inhibition efficacy on telomerase activity, and recombinant LPTS proteins claimed by a couple of patents seem to be potential anti-cancer agents...
  61. doi miR-411 regulated ITCH expression and promoted cell proliferation in human hepatocellular carcinoma cells
    Kunkun Xia
    Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, People s Republic of China Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, People s Republic of China
    Biomed Pharmacother 70:158-63. 2015
    ....
  62. pmc Metastatic pathway-specific transcriptome analysis identifies MFSD4 as a putative tumor suppressor and biomarker for hepatic metastasis in patients with gastric cancer
    Mitsuro Kanda
    Department of Gastroenterological Surgery Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Oncotarget 7:13667-79. 2016
    ..MFSD4 expression in gastric tissues may represent a useful biomarker for identification of patients at high risk for hepatic recurrence, metastasis, or both. ..
  63. ncbi Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1)
    A Courseaux
    LGMCH, CNRS URA 1462, Nice, France
    Genomics 37:354-65. 1996
    ..Two critical recombinants identified in two affected cases placed the MEN1 gene in an approximately 2-Mb region around PYGM, flanked by D11S1883 and D11S449...
  64. ncbi Localization and expression of p27KIP1 in multistage colorectal carcinogenesis
    M Ciaparrone
    Centro di Ricerche Oncologicalhe Giovanni XXXIII Università Cattolica del Sacro Cuore, Rome, Italy
    Cancer Res 58:114-22. 1998
    ..This may reflect the existence of a homeostatic feedback mechanism that is lost in the high-grade carcinomas that express low levels of p27Kip1...
  65. ncbi Screening and identification of down-regulated genes in colorectal carcinoma by subtractive hybridization: a method to identify putative tumor suppressor genes
    S Zheng
    Cancer Institute, Zhejiang Medical University, Hangzhou, China
    Chin Med J (Engl) 110:543-7. 1997
    ..To search for new putative tumor suppressor genes in colorectal carcinoma...
  66. pmc Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins
    S S Lee
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Virol 74:9680-93. 2000
    ....
  67. ncbi Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14
    B Kapanadze
    Radiumhemmets Research Laboratory, CCK, R8 03, Karolinska Hospital, Stockholm, S 171 76, Sweden
    Genomics 70:327-34. 2000
    ..However, our data also show that in terms of transcribed sequences, only two of those, human LEU2 and LEU5/RFP2, are clearly conserved, strengthening the case for these genes as putative candidate B-CLL tumor suppressor genes...
  68. ncbi Characterization of the homeodomain gene EMX2: sequence conservation, expression analysis, and a search for mutations in endometrial cancers
    F C Noonan
    Department of Surgery, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri, 63110, USA
    Genomics 76:37-44. 2001
    ..Inactivation or reduced expression of EMX2 in cancers, coupled with increased expression in the quiescent endometrium, indicate that this homeodomain gene is involved in maintenance of the differentiated state...
  69. ncbi A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation
    Andrei M Mikheev
    Program in Cancer Biology, Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, WA 98104 2092, USA
    Carcinogenesis 25:47-59. 2004
    ..Taken together, our results indicate that somatic cell genetics combining with gene expression profiling may be a useful approach for the identification of functional suppressors of malignant cell growth...
  70. ncbi Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells
    Santiago Ropero
    Cancer Epigenetics Laboratory, Spanish National Cancer Centre, Madrid, Spain
    Hum Mol Genet 13:2753-65. 2004
    ..These findings highlight the importance of EXT1 epigenetic inactivation, leading to an abrogation of HS biosynthesis, in the processes of tumor onset and progression...
  71. ncbi GADD45A and EPB41 as tumor suppressor genes in meningioma pathogenesis
    S Piaskowski
    Department of Molecular Pathology and Neuropathology, Chair of Oncology, Medical University, Czechoslowacka st 8 10, 92 216 Lodz, Poland
    Cancer Genet Cytogenet 162:63-7. 2005
    ..EPB41 gene expression was unchanged in all analyzed meningiomas. This suggests that involvement of the EPB41 gene (4.1R protein) in meningioma pathogenesis should be reconsidered...
  72. ncbi Genetic characterization of fas-associated phosphatase-1 as a putative tumor suppressor gene on chromosome 4q21.3 in hepatocellular carcinoma
    Shiou Hwei Yeh
    Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
    Clin Cancer Res 12:1097-108. 2006
    ..We studied the Fas-associated phosphatase-1 (FAP-1) gene as a potential candidate TSG in this region...
  73. ncbi Parafibromin tumor suppressor enhances cell growth in the cells expressing SV40 large T antigen
    T Iwata
    Department of Medical Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Oncogene 26:6176-83. 2007
    ..The tumor suppressor protein PF acts as a positive regulator of cell growth similar to an oncoprotein in the presence of SV40 large T antigen...
  74. pmc Parkin enhances the expression of cyclin-dependent kinase 6 and negatively regulates the proliferation of breast cancer cells
    Shiam Peng Tay
    Neurodegeneration Research Laboratory, National Neuroscience Institute, Singapore 308433, Singapore
    J Biol Chem 285:29231-8. 2010
    ..Taken together, our results support a negative role for parkin in tumorigenesis and provide a potential mechanism by which parkin exerts its suppressing effects on breast cancer cell proliferation...
  75. doi Human homolog of Drosophila expanded, hEx, functions as a putative tumor suppressor in human cancer cell lines independently of the Hippo pathway
    S Visser-Grieve
    Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada
    Oncogene 31:1189-95. 2012
    ..This is the first study to functionally characterize hEx and show that hEx acts in a distinct manner compared with Drosophila expanded...
  76. pmc Post-GWAS functional characterization of susceptibility variants for chronic lymphocytic leukemia
    Fenna C M Sillé
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, United States of America
    PLoS ONE 7:e29632. 2012
    ....
  77. doi Frequent loss of tumor suppressor ARID1A protein expression in adenocarcinomas/adenosquamous carcinomas of the uterine cervix
    Atsuko Katagiri
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Shimane, Japan
    Int J Gynecol Cancer 22:208-12. 2012
    ..This study investigated whether ARID1A expression was also lost in cervical squamous cell carcinomas and adenocarcinomas/adenosquamous carcinomas...
  78. pmc Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells
    Yan Shen
    GI Cancer Research Laboratory, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, TX, USA
    Cancer Biol Ther 13:542-52. 2012
    ....
  79. doi Down expression of LRP1B promotes cell migration via RhoA/Cdc42 pathway and actin cytoskeleton remodeling in renal cell cancer
    Shaobin Ni
    School of Life Science and Technology, Harbin Institute of Technology, Harbin, China
    Cancer Sci 104:817-25. 2013
    ..Taken together, these results strongly support that LRP1B may function as a tumor suppressor against renal cell cancer, and may regulate cell motility via RhoA/Cdc42 pathway and actin cytoskeleton reorganization in RCC. ..
  80. pmc TUSC3 loss alters the ER stress response and accelerates prostate cancer growth in vivo
    Peter Horak
    Division of Oncology, Department of Internal Medicine I and Comprehensive Cancer Center Medical University of Vienna, Austria
    Sci Rep 4:3739. 2014
    ..Together, our findings provide first mechanistic insight in TUSC3 function in prostate carcinogenesis in general and N-glycosylation in particular. ..
  81. doi Molecular characterization, immune responsive expression and functional analysis of QM, a putative tumor suppressor gene from the Pacific white shrimp, Litopenaeus vannamei
    Yongjie Liu
    College of Animal Science and Technology, Northwest A and F University, Yangling, 712100 Shaanxi, China
    Fish Shellfish Immunol 37:1-10. 2014
    ..Hence, we conclude that LvQM was involved in the host defense of L. vannamei, probably as a positive regulator to phenoloxidase activity. ..
  82. pmc PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling
    Ashley L Hein
    Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska
    Cancer Res 76:2243-53. 2016
    ..These studies also provide a basis for exploring PR55α as a diagnostic or therapeutic target in pancreatic cancer. Cancer Res; 76(8); 2243-53. ©2016 AACR...
  83. pmc Efficacy of glycogen synthase kinase-3β targeting against osteosarcoma via activation of β-catenin
    Shingo Shimozaki
    Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan
    Oncotarget 7:77038-77051. 2016
    ..Our study thereby demonstrates a critical role for GSK-3β in sustaining survival and proliferation of osteosarcoma cells, and identifies this kinase as a potential therapeutic target against osteosarcoma...
  84. doi Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC
    Daria A Gaykalova
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Oncotarget . 2017
    ....
  85. pmc The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers
    H Aberle
    Max Planck Institut für Immunobiologie, Freiburg, Germany
    Proc Natl Acad Sci U S A 92:6384-8. 1995
    ..Our results, together with the present knowledge about the biological function of plakoglobin, suggest that plakoglobin might represent a putative tumor suppressor gene for breast and ovarian cancers...
  86. ncbi Isolation of 45 exon-like fragments from 8p22-->p21.3, a region that is commonly deleted in hepatocellular, colorectal, and non-small cell lung carcinomas
    K Chinen
    Laboratory of Molecular Medicine, University of Tokyo, Japan
    Cytogenet Cell Genet 75:190-6. 1996
    ..The map and the exon-like fragments reported here will be useful resources for isolation of the putative tumor suppressor gene(s) as well as other novel genes located in the 8p22-->p21.3 region...
  87. ncbi The putative tumor suppressor gene FHIT at 3p14.2 is rarely affected by loss of heterozygosity in primary human brain tumors
    S Frank
    Department of Surgical Research, Technical University of Dresden, Germany
    Cancer Res 57:2638-41. 1997
    ..In contrast, observed LOH rate for brain metastases was as high as 54.5% (n = 45), in accordance with data thus far accumulated from analyses of corresponding primary tumors...
  88. ncbi Human/mouse microcell hybrid based elimination test reduces the putative tumor suppressor region at 3p21.3 to 1.6 cM
    A Szeles
    Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
    Genes Chromosomes Cancer 20:329-36. 1997
    ..We have defined a common eliminated region of approximately 1.6 cM (designated as CER1) inside the 7 cM CER described earlier. CER1 is flanked distally by D3S1029 and proximally by D3S643...
  89. ncbi Abnormalities of fragile histidine triad genomic and complementary DNAs in cervical cancer: association with human papillomavirus type
    C Y Muller
    Department of Obstetrics and Gynecology, Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas 75235 9032, USA
    J Natl Cancer Inst 90:433-9. 1998
    ..We examined abnormalities in FHIT and its RNA transcripts in cervical cancer cell lines and tumors. We also investigated the relationship between loss of heterozygosity (LOH) in FHIT/FRA3B and the presence of oncogenic HPV types...
  90. ncbi Frequent allelic loss on chromosome 9 in hepatocellular carcinoma
    C T Liew
    Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Faculty of Medicine, Chinese University of Hong Kong, Shatin
    Int J Cancer 81:319-24. 1999
    ..Our data also suggest that inactivation of the p16 and the p15 genes and the possibility of other unknown tumor-suppressor genes located on these defined deleted regions of chromosome 9 may be involved in the pathogenesis of HCC...
  91. ncbi Expression of BRCA1 and BRCA2 in normal and neoplastic cells
    L A Chodosh
    Department of Molecular and Cellular Engineering, University of Pennsylvania School of Medicine, Philadelphia 19104 6100, USA
    J Mammary Gland Biol Neoplasia 3:389-402. 1998
    ..These observations have contributed to the emerging hypothesis that these genes function in similar regulatory pathways...
  92. ncbi Down-regulation in human cancers of DRHC, a novel helicase-like gene from 17q25.1 that inhibits cell growth
    H Nagai
    Department of Molecular Biology, Institute of Gerontology, Nippon Medical School 1 396, Kosugi cho, Nakahara ku, Kawasaki 211 0063, Japan
    Cancer Lett 193:41-7. 2003
    ..Transfection of a DRHC expression vector inhibited growth of cancer cells in liquid medium or soft agar. The results suggest that loss of expression of DRHC may play a role in human carcinogenesis...
  93. ncbi Genetic analysis identifies putative tumor suppressor sites at 2q35-q36.1 and 2q36.3-q37.1 involved in cervical cancer progression
    Gopeshwar Narayan
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Oncogene 22:3489-99. 2003
    ..Thus, these data identify frequent chromosomal amplifications in CC, and sites of TSGs at 2q35-q36.1 and 2q36.3-q37.1 that are critical in CC development...
  94. ncbi Identification and characterization of the murine TRPM4 channel
    Manabu Murakami
    Department of Pharmacology, Akita University School of Medicine, 1 1 1, Hondou, Akita 010 8543, Japan
    Biochem Biophys Res Commun 307:522-8. 2003
    ..Both TRPM4 variants integrated into the plasma membrane. Furthermore, FRET analysis revealed that TRPM4a and TRPM4b localized close together, suggesting a multimerization of the two molecules...
  95. ncbi 3p21, 5q21, 9p21 and 17p13 allelic deletions accumulate in the dysplastic spectrum of laryngeal carcinogenesis and precede malignant transformation
    J Sanz-Ortega
    Department of Pathology, San Carlos Clinic Hospital, Madrid, Spain
    Histol Histopathol 18:1053-7. 2003
    ..These genomic changes in pre-malignant laryngeal lesions could be of potential use as markers for cancer risk assessment...
  96. pmc Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma
    Tamotsu Takeuchi
    Department of Pathology, Kochi Medical School, Kochi, Japan
    Am J Pathol 163:1395-404. 2003
    ..The present findings suggest that skeletrophin may be a novel actin-binding cytoskeleton-related molecule, expression of which is silenced in a considerable number of melanoma specimens...
  97. ncbi Frequent epigenetic inactivation of the RASSF1A tumor suppressor gene in Hodgkin's lymphoma
    Paul G Murray
    Department of Pathology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Oncogene 23:1326-31. 2004
    ..Inactivation of RASSF1A could be one mechanism by which HRS cells escape the apoptosis that should occur following nonproductive immunoglobulin gene rearrangements...
  98. ncbi Definition of a region of loss of heterozygosity at chromosome 11q23.3-25 in head and neck squamous cell carcinoma using laser capture microdissection technique
    Dongfeng Tan
    Department of Pathology, Roswell Park Cancer Institute, State University of New York at Buffalo, Buffalo, NY 14263, USA
    Diagn Mol Pathol 13:33-40. 2004
    ..3-25 was defined. LOH in this region may harbor putative tumor suppressor gene(s) critical for HNSCC. Furthermore, these allelic losses were not found in any non-neoplastic squamous tissue samples, clarifying prior discrepant data...
  99. ncbi Quantitative detection of promoter hypermethylation of multiple genes in the tumor, urine, and serum DNA of patients with renal cancer
    Mohammad Obaidul Hoque
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, 720 Rutland Avenue, Baltimore, MD 21287, USA
    Cancer Res 64:5511-7. 2004
    ..This noninvasive high-throughput approach needs to be evaluated in large studies to assess its value in the early detection and surveillance of renal cancer...
  100. ncbi A 700-kb physical and transcription map of the cervical cancer tumor suppressor gene locus on chromosome 11q13
    Kayvan Zainabadi
    Department of Surgery 10H2, VAGLAHS West Los Angeles, David Geffen School of Medicine, University of California at Los Angeles, Building 304, Room E2 218, 11301 Wiltshire Boulevard, West Los Angeles, CA 90073, USA
    Genomics 85:704-14. 2005
    ..The physical and transcription maps and the microsatellite markers of the 700-kb region of chromosome 11q13 should be helpful in the cloning of the cervical cancer tumor suppressor gene...
  101. ncbi IGFBP-3 expression in hepatocellular carcinoma involves abnormalities in TGF-beta and/or Rb signaling pathways
    Eiichiro Yumoto
    Department of Medicine, Okayama University Graduate School of Medicine and Dentistry, Japan
    Int J Oncol 27:1223-30. 2005
    ..The present study suggests that IGFBP-3 mediates growth suppression signals via the TGF-beta and/or Rb pathways in HCC...

Research Grants66

  1. Michael A Caligiuri; Fiscal Year: 2014
    ..Funding of this proposal will advance our understanding of basic immunology as well as strategies to prevent and treat cancer. ..
  2. MOLECULAR PROGRESSION MODEL FOR HNSCC
    David Sidransky; Fiscal Year: 2012
    ..These early molecular events will be identified and developed as targets for early detection and staging approaches, with emphasis on molecular detection strategies amenable to rapid, automated application. ..
  3. TUMOR SUPPRESSOR GENES IN HUMAN THYROID NEOPLASMS
    James Fagin; Fiscal Year: 1990
    ....
  4. ISOLATION OF TUMOR SUPPRESSOR GENES IN RHABDOMYOSARCOMA
    Mary Sugrue; Fiscal Year: 2000
    ..Selection of RD transfectants based on induction of a growth- inhibited or differentiated phenotype will be attempted. 3) Molecular characterization of putative tumor suppressor gene(s). ..
  5. ALLELE LOSS IN THE GENESIS OF GASTRIC CANCER
    Barbara Schneider; Fiscal Year: 1999
    ..Since these proteins are likely to participate critically in reducing cell proliferation the study of each of them holds the potential to reveal more specific therapies for cancer. ..
  6. Characterization of Human 3p Recessive Oncogenes
    John Minna; Fiscal Year: 2004
    ..mutation, suppression of the malignant phenotype) including CACNA2D2, 101F6, NPR21/G21, BLU, FUSI, HYAL1, and FUS2. The current proposal will: Confirm the tumor suppressing function of RASSF1A and SEMA3B and further implicate or ..
  7. Detection of Novel Gene Defects in Basal Cell Carcinoma
    Steven Fakharzadeh; Fiscal Year: 2005
    ..abstract_text> ..
  8. Use of RNAi to investigate cullin-5 function in breast cancer
    Michael Fay; Fiscal Year: 2006
    ..A better understanding of cancer-related genes, such as Cul5, is expected to lead to better therapies for patients. [unreadable] [unreadable] [unreadable] [unreadable]..
  9. STATISTICAL METHODS FOR MOLECULAR CANCER DATA
    Michael Newton; Fiscal Year: 1999
    ..Computer simulation of the model will be useful both to study bias and variance properties of the proposed methods and as the basis for power calculations to design marker studies. ..
  10. SIGNIFICANCE OF ALLELIC DELETIONS IN NEUROBLASTOMA
    John Maris; Fiscal Year: 1999
    ..These studies should also substantially contribute towards the positional cloning of three neuroblastoma suppressor genes and our basic understanding of the molecular genetics of this common pediatric tumor. ..
  11. CLONING A GENE AT 12Q22 DELETION IN GERM CELL TUMORS
    Murty Vundavalli; Fiscal Year: 2001
    ..Subsequently, the TSG will be characterized as to its evolutionalry conservation, genomic organization, normal function, and specific role in tumorigenesis. ..
  12. SIGNALING MECHANISM IN DCC-INDUCED APOPTOSIS
    Yong Chen; Fiscal Year: 2003
    ....
  13. Pier Paolo Pandolfi; Fiscal Year: 2014
    ..In view of the critical role exerted by this protein in tumorigenesis and embryonic development the further elucidation of POKEMON/LRF function and role in human cancer is of great relevance to biomedical research. ..
  14. Regulation of Pancreatic Tumor Progression by Disabled-2
    Barbara A Hocevar; Fiscal Year: 2010
    ..The studies proposed here will provide prelimary evidence to support a role of Disabled-2 in prevention of pancreatic tumor progression and metastasis which may lead to improved diagnosis and treatment of pancreatic cancer. ..
  15. ADAM ROBERT BROWN; Fiscal Year: 2014
    ..The successful completion of the study will provide insight into potential age-dependent targets that may lead to the development of new therapies to prevent or treat age-related colorectal cancer. ..
  16. Investigation of Notch-inhibiting microRNAs in glioma
    Benjamin W Purow; Fiscal Year: 2013
    ..In this proposal, we will investigate two microRNAs as tumor suppressors and therapies in glioma secondary to their inhibition of the Notch pathway, a central pathway in stem cells, cell fate, and cancer. ..
  17. Zijie Sun; Fiscal Year: 2015
    ..Insights into new diagnostic markers, therapeutic targets and approaches for prostate cancer and other tumors are expected. ..
  18. Role of the Putative Tumor Suppressor PinX1 in the Etiology of Liver Cancer
    Xiao Zhen Zhou; Fiscal Year: 2010
    ..These studies would establish new animal models for studying liver cancer and provide novel insight into the etiology and treatment of liver cancer. ..
  19. Mingjiang Xu; Fiscal Year: 2016
    ..The Tet2 murine models also offer a biological context in which drugs and other therapies can be tested and developed. ..
  20. Semaphorin 3F: Structure, Function, and Anti-Metastatic Activity
    Diane Renee Bielenberg; Fiscal Year: 2010
    ..Most of all, a Howard Temin Award would enable the continuation of this research project toward the ultimate goal of long-term stable disease. ..
  21. SARA MARIE FRANCIS-REED; Fiscal Year: 2014
    ..My ultimate goal is to become an independent physician scientist studying pediatric cancers. I am excited that this training experience will effectively prepare me for such a career in translational cancer research. ..
  22. LCM Analysis and Mouse Models to Validate miRs in Prostate Tumor Progression
    ZENDRA ELIZABETH ZEHNER; Fiscal Year: 2012
    ....
  23. KLF4 Genetic and Epigenetic Changes in Human Pancreatic Cancer
    Keping Xie; Fiscal Year: 2012
    ..However, the critical role of KLF4 signaling in human cancer development and progression in general and human pancreatic cancer in particular is unclear. ..
  24. CORRELATIVE STUDIES USING SPECIMENS FROM SWOG 9321
    John Shaughnessy; Fiscal Year: 2000
    ..Specific Aim 3: Evaluate whether chromosome 13 deletions correlate with clinical outcome (complete remission, event free survival, and overall survival). ..
  25. CLONING NOVEL GENES FOR PAGETS DISEASE AND OSTEOSARCOMA
    Marc Hansen; Fiscal Year: 2001
    ....
  26. MECHANISMS OF ENZYMATIC REACTIONS
    PERRY FREY; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  27. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2006
    ..We are ultimately working to elucidate the origin and causes of a cancer that might be preventable. [unreadable] [unreadable]..
  28. DNA METHYLATION AND SOD2/MNSOD GENE EXPRESSION
    Frederick Domann; Fiscal Year: 2002
    ..A better understanding of the mechanisms of regulation of the expressio of SOD2 during carcinogenesis and differentiation may lead to new strategies for the treatment of diseases in which aberrant SOD2 expression plays a key role. ..
  29. SUPPRESSION OF TUMOR PROGRESSION BY CONNEXIN 43
    Shu Chih Chen; Fiscal Year: 2000
    ....
  30. MOLECULAR ANALYSIS OF THE DEL(20Q) IN MYELOID LEUKEMIAS
    MICHELLE LE BEAU; Fiscal Year: 2003
    ..abstract_text> ..
  31. Identification of Receptor for Tumor Suppressor HIN-1
    Dale Porter; Fiscal Year: 2003
    ..abstract_text> ..
  32. Characterization of HIN1 Putative Tumor Suppressor
    Ian Krop; Fiscal Year: 2003
    ..The results of these studies will thus determine the role of HIN-1 as a potential tumor suppressor gene and, since it is inactivated frequently in early BC, may provide an excellent target for preventive intervention. ..
  33. METABOLISM AND TOXICITY OF HYDROQUINONE-THIOETHERS
    Serrine Lau; Fiscal Year: 2003
    ..The overall goals of this aim are to characterize the Eker animal model in which the effects of environmental influences (chemical exposure) on a genetic predisposition to cancer are determined. ..
  34. Function and Regulation of Pin2/TRF1 and PinX1
    Kun Ping Lu; Fiscal Year: 2005
    ..These studies should yield new insights into telomere maintenance, cell growth control and oncogenesis, and may lead to the development of new anticancer therapy. ..
  35. MAPPING GENETIC SUPPRESSORS OF EPIGENETIC CARCINOGENESIS
    Helmut Zarbl; Fiscal Year: 2002
    ....
  36. PinX1, a Putative Tumor Suppressor for Prostate Cancer
    Xiao Zhou; Fiscal Year: 2004
    ..Furthermore, these pilot studies are novel and will serve as the first step in obtaining R01 support from NIH to start a new project on prostate cancer. ..
  37. DNA polymerase iota as a putative tumor suppressor
    William G McGregor; Fiscal Year: 2010
    ..The ultimate goal of this research is to understand how carcinogens cause cancer in order to design strategies to prevent the disease. ..
  38. CELL CYCLE REGULATORS OF ORAL CANCER
    JAMES RHEINWALD; Fiscal Year: 2002
    ..These Cores will also validate conclusions from the research projects in human oral cancer tissues. ..
  39. DNA methylation patterns as biomarker for breast cancer
    Kristin Skinner; Fiscal Year: 2003
    ..These future studies will determine whether DNA methylation changes can be used a) to stratify women at risk for breast cancer and b) as a surrogate endpoint in chemoprevention trials. ..
  40. BRCA1 AND DIFFERENTIATION AND ENDOCRINE RISK FACTOR
    Lewis Chodosh; Fiscal Year: 2000
    ..Ultimately, understanding the role played by BRCA1 in the regulation of these processes has the potential to lead to novel strategies for the prevention and treatment of breast cancer. ..
  41. Regulation of Bcl2 Function Via Ceramide-Activated PP2A
    Peter Ruvolo; Fiscal Year: 2006
    ..From these results, it is expected that the development of novel anticancer strategies that target mechanisms regulating Bc12 function will occur...
  42. Genetic Modifiers of p53
    Susan Evans; Fiscal Year: 2005
    ..abstract_text> ..
  43. EXPRESSION AND FUNCTION OF CUL 5/VACM 1 IN BREAST CANCER
    Michael Fay; Fiscal Year: 2000
    ..abstract_text> ..
  44. CHROMOSOME 9P ABERRATIONS IN GLIOMA
    Dennis Carson; Fiscal Year: 1999
    ....
  45. LYSYL OXIDASE GENE MUTATIONS IN COLON CANCER
    Katalin Csiszar; Fiscal Year: 2001
    ..This proposal seeks to characterize these 5q23 rearrange- ments in order to begin to understand the role of lysyl oxidase gene mutations in the cascade of genetic events that lead to colorectal tumorigenesis. ..
  46. DOC-1R, A NOBEL CDK2-ASSOCIATED PROTEIN
    Xue Zhang; Fiscal Year: 2000
    ..The long term goal of this proposal is to substantiate the role of DOC-1R as a new CDK2 regulatory protein, in the regulation of CDK2-mediated cell cycle biology in normal and tumor development. ..
  47. APC2 AND BREAST CANCER
    Stephen Byers; Fiscal Year: 2002
    ..Targets of beta-catenin signaling include cyclin Dl and c-myc, both of which are commonly overexpressed in human breast cancers. We will relate the cytogenetics of APC2 to the expression of cyclin D1 and c-myc breast cancers. ..
  48. Influence of ErbB4 activity on metastatic breast cancer
    Frank Jones; Fiscal Year: 2007
    ..abstract_text> ..
  49. Formulation & Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention
    Susan Mallery; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  50. Mammary Development and Breast Cancer Susceptibility
    Lewis Chodosh; Fiscal Year: 2005
    ..We anticipate that these studies will help to illuminate developmental mechanisms that contribute to the determination of breast cancer susceptibility. ..
  51. Chemoprevention of Oral Dysplasia by Black Raspberries
    Susan Mallery; Fiscal Year: 2005
    ..This experimental design (comparison of pretreatment and post-treatments tissues) permits each patient to serve as their own internal control. ..
  52. Temporal Analysis of Mammary Carcinogenesis
    Lewis Chodosh; Fiscal Year: 2005
    ....
  53. Retinoic Acid Regulated Cell Differentiation: BLR1 Rcptr
    Andrew Yen; Fiscal Year: 2005
    ..It has the implication that the ultimate effects of RA can be governed by relevant growth factors signaling through their cognate receptors. ..
  54. ROLE OF FRAGILE SITES IN CHROMOSOME BREAKAGE AND CANCER
    Thomas Glover; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  55. FOXC2 in Hereditary Lymphedema and Lymphatic Development
    Thomas Glover; Fiscal Year: 2007
    ..abstract_text> ..
  56. Role of Oxidants & Angiogenesis in Kaposi's Sarcoma
    Susan Mallery; Fiscal Year: 2007
    ..Elucidation of these interactions will not only clarify KS pathogenic mechanisms, but will also identify sites for KS therapeutic intervention. ..
  57. BRCA2 FUNCTION IN MAMMARY EPITHELIAL BIOLOGY
    Lewis Chodosh; Fiscal Year: 2002
    ..We will also determine whether Brca2 is posttranslationally modified following DNA damage in a manner similar to that observed for Brca1. Finally, we will determine whether Brca2 and Brca1 interact during these processes. ..
  58. P27Kipl deficiency, potential promoter of carcinogenesis
    Konstantin Christov Tzelkov; Fiscal Year: 2003
    ..abstract_text> ..
  59. Mechanisms of Progression in c-MYC-Induced Breast Cancer
    Lewis Chodosh; Fiscal Year: 2006
    ..abstract_text> ..
  60. PARADIGM OF MULTISTEP URINARY BLADDER CARCINOGENESIS
    Bogdan Czerniak; Fiscal Year: 2006
    ....
  61. Conference Proposal: Calcium and Cell Function
    Craig Montell; Fiscal Year: 2004
    ..The topics to be covered at the meeting are of fundamental importance and are relevant to understanding the bases of a diseases such as neurodegeneration, communicative disorders, aging, cancer, kidney and cardiovascular disease. ..
  62. FLUORESCENCE ACTIVATED CELL SORTER
    Andrew Yen; Fiscal Year: 2004
    ..The instrument requested is a Dako-Cytomation basic MoFlo plus a UV-vis, vis, and HeNe laser to provide independent UV, vis/488, and red excitation. ..
  63. HUNK AND PUNC FUNCTION IN MAMMARY EPITHELIAL BIOLOGY
    Lewis Chodosh; Fiscal Year: 2004
    ....
  64. Biomarker modulation/COX-2 inhibitor/Breast Cancer
    Banu Arun; Fiscal Year: 2003
    ..Ultimately, the development of non-hormonal chemoprevention agents, and identification of surrogate markers will allow us to plan large-scale, phase III chemoprevention studies with the endpoint of cancer incidence. ..
  65. TOPOISOMERASES IN RETINOID INDUCED DIFFERENTIATION
    Andrew Yen; Fiscal Year: 2003
    ..Andrew Yen, who brings expertise on the molecular and cellular biology of retinoic acid-induced myeloid differentiation. ..