Genomes and Genes
Gene Symbol: NAT6
Description: N-acetyltransferase 6
Alias: FUS-2, FUS2, N-acetyltransferase 6 (GCN5-related), protein fusion-2
Publications278 found, 100 shown here
- The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene ConsortiumM I Lerman
Laboratory of Immanobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
Cancer Res 60:6116-33. 2000..of the genes to have two or more amino acid sequence-altering mutations including BLU, NPRL2/Gene21, FUS1, HYAL1, FUS2, and SEMA3B...
- Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomasPaulisally Hau Yi Lo
Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, People s Republic of China
Cancer Lett 234:184-92. 2006The expression of six chromosome 3p21.3 candidate tumor suppressor genes (BLU, FUS2, HYAL2, NPRL2, RASSF1A, and SEMA3B) in esophageal squamous cell carcinoma (ESCC) has been investigated...
- Familial partial monosomy 7 and myelodysplasia: different parental origin of the monosomy 7 suggests action of a mutator geneA Minelli
Biologia Generale e Genetica Medica, , C.P. 217, I 27100, Pavia, Italy
Cancer Genet Cytogenet 124:147-51. 2001..We postulate that, in fact, an inherited mutation in any of a group of mutator genes causes familial monosomy 7 also in the absence of a recognized mendelian disease, and that marrow chromosome 7 anomalies, in turn, lead to MDS/AML...
- [Detailed mapping and clinical significance of loss of heterozygosity on 9p13-23 in laryngeal squamous cell carcinoma by microsatellite analysis]Xian fa Xu
Department of Otolaryngology Head and Neck Surgery, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing, PR China
Ai Zheng 22:452-7. 2003..This study was designed to refine the hot spots of LOH on 9p13-23 in laryngeal squamous cell carcinoma and compare the correlation between the incidence of microsatellite LOH and the clinicopathological parameters...
- Transcriptional repression mediated by the WT1 Wilms tumor gene productS L Madden
Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104
Science 253:1550-3. 1991..The repression function was mapped to the glutamine- and proline-rich NH2-terminus of WT1; fusion of this domain to the zinc finger region of EGR-1 converted EGR-1 into a transcriptional repressor...
- Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 proteinHansoo Lee
Department of Pathology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
Mol Cell Biol 27:2103-19. 2007..Collectively, these findings indicate that NGB is a tumor suppressor that regulates and requires merlin to suppress cell proliferation...
- Allelotyping in mycosis fungoides and Sézary syndrome: common regions of allelic loss identified on 9p, 10q, and 17pJ J Scarisbrick
Skin Tumour Unit, St John s Institute Dermatology, St Thomas Hospital, London, UK
J Invest Dermatol 117:663-70. 2001..These results provide the basis for further studies defining more accurately chromosomal regions of deletions and candidate tumor suppressor genes involved in mycosis fungoides and Sézary syndrome...
- ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathwaysMichele A Battle
Carcinogenesis Laboratory, Cell and Molecular Biology Program, Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 1302, USA
Biochemistry 42:7270-82. 2003..Clearly, ST7 is an LRP, and therefore, it should now be referred to as LRP12...
- Screening and identification of down-regulated genes in colorectal carcinoma by subtractive hybridization: a method to identify putative tumor suppressor genesS Zheng
Cancer Institute, Zhejiang Medical University, Hangzhou, China
Chin Med J (Engl) 110:543-7. 1997..To search for new putative tumor suppressor genes in colorectal carcinoma...
- Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosisTimothy A Chan
Cancer Biology Program, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland, United States of America
PLoS Med 5:e114. 2008..We hypothesize that key tumor suppressor genes in cancer may be subject to mutation or hypermethylation...
- mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cellsLi Hui
Department of Biological Sciences, Hunter College of the City University of New York, New York, New York 10021, USA
J Biol Chem 280:35829-35. 2005..The ability of phospholipase D to suppress protein phosphatase 2A identifies a critical target of an emerging phospholipase D/mTOR survival pathway in the transformation of human cells...
- Fus2 localizes near the site of cell fusion and is required for both cell fusion and nuclear alignment during zygote formationE A Elion
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
J Cell Biol 130:1283-96. 1995..Genetic evidence suggests that the FUS2 gene product promotes cell fusion during zygote formation in Saccharomyces cerevisiae, functioning with the Fus1 ..
- A retinoic acid receptor beta/gamma-selective prodrug (tazarotene) plus a retinoid X receptor ligand induces extracellular signal-regulated kinase activation, retinoblastoma hypophosphorylation, G0 arrest, and cell differentiationAndrew Yen
Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Mol Pharmacol 66:1727-37. 2004..Tazarotene used with RXR-selective ligand may thus be a useful antineoplastic agent in differentiation induction therapy as exemplified by the prototypical RA treatment of acute promyelocytic leukemia...
- Merlin knockdown in human Schwann cells: clues to vestibular schwannoma tumorigenesisZana Ahmad
Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of California San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, U S A
Otol Neurotol 31:460-6. 2010..To investigate the early events in molecular progression toward schwannoma tumorigenesis, we developed an in vitro model of human Schwann cell tumorigenesis by merlin knockdown...
- Frequent loss of heterozygosity at the 19p13.3 locus without LKB1/STK11 mutations in human carcinoma metastases to the brainS B Sobottka
Department of Neurosurgery, Technical University of Dresden, Germany
J Neurooncol 49:187-95. 2000..Based on these findings, the genes adjacent to LKB1/STK11 may be relevant for the development of metastases to the brain from certain carcinomas...
- Frequent occurrence of Ha-rasl allelic deletion in human ovarian adenocarcinomasA Viel
Division of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano, Pordenone, Italy
Tumori 77:16-20. 1991..These findings may suggest that a putative tumor suppressor gene closely linked to Ha-rasl in 11p15.5 is involved in ovarian cancerogenesis...
- Analysis of the candidate tumor suppressor Ris-1 in primary human breast carcinomasJavier Silva
Department of Medical Oncology, Hospital Universitario Puerta de Hierro, c San Martin de Porres, E 28035 Madrid, Spain
Mutat Res 594:78-85. 2006..Future and larger series studies in different tumor types are necessary to clarify Ris-1 function in human cancer...
- Diminished levels of the putative tumor suppressor proteins EXT1 and EXT2 in exostosis chondrocytesM A Bernard
Department of Pediatrics, University of Texas Houston Medical School, Houston, Texas 77225 0708, USA
Cell Motil Cytoskeleton 48:149-62. 2001..These results suggest that multiple mutational steps are involved in exostosis development and that EXT genes play a role in cell signaling related to chondrocyte cytoskeleton regulation...
- Down-regulation of SFRP1 as a putative tumor suppressor gene can contribute to human hepatocellular carcinomaJian Huang
Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China
BMC Cancer 7:126. 2007..However, whether the down-regulation of SFRP1 can contribute to hepatocarcinogenesis still remains unclear...
- Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migrationYonghe Li
Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, Missouri 63110, USA
J Biol Chem 277:42366-71. 2002..Taken together, these results demonstrate that LRP1B can function as a negative regulator of uPAR regeneration and cell migration...
- Inhibition of growth by p205: a nuclear protein and putative tumor suppressor expressed during myeloid cell differentiationJonathan M Dermott
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, MD 21702 1201, USA
Stem Cells 22:832-48. 2004..We propose that during myelomonocytic cell differentiation, induction of p205 expression contributes to cell growth arrest, thus allowing progenitor cells to differentiate...
- Loss of heterozygosity on chromosome 22q in gastrointestinal stromal tumors (GISTs): a study on 50 casesJerzy Lasota
Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Lab Invest 85:237-47. 2005..An isolated LOH at D22S425 was equally found in both benign and malignant tumors. These observations may suggest that LOHs on chromosome 22q in GISTs play a role in early stages of tumor formation as well as in late tumor progression...
- The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide productionJudy A Cam
Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 279:29639-46. 2004..These findings reveal that LRP1B is a novel binding partner of APP that functions to decrease APP processing to Abeta. Consequently LRP1B expression could function to protect against the pathogenesis of Alzheimer's disease...
- Microdissecting the genetic events in nephrogenic rests and Wilms' tumor developmentA K Charles
Department of Pediatric Pathology, St Michael s Hospital, Bristol, United Kingdom
Am J Pathol 153:991-1000. 1998..Intralobar and perilobar nephrogenic rests are known to have different biological behaviors, and this study suggests that they are genetically different. A multistep model of Wilms' tumor pathogenesis is supported by these findings...
- Epigenetic inactivation of the premature aging Werner syndrome gene in human cancerRuben Agrelo
Cancer Epigenetics Laboratory, Spanish National Cancer Centre, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
Proc Natl Acad Sci U S A 103:8822-7. 2006..These findings highlight the importance of WRN epigenetic inactivation in human cancer, leading to enhanced chromosomal instability and hypersensitivity to chemotherapeutic drugs...
- Non-linkage of familial rhabdoid tumors to SMARCB1 implies a second locus for the rhabdoid tumor predisposition syndromeMichael C Frühwald
University Children s Hospital Muenster, Department of Paediatric Haematology and Oncology, Muenster, Germany
Pediatr Blood Cancer 47:273-8. 2006..2. Several familial cases have been published and summarized under the term rhabdoid tumor predisposition syndrome. In all of the published familial cases, inactivation of SMARCB1 was detected in tumor tissues...
- Genetic analysis of childhood germ cell tumors with comparative genomic hybridizationD T Schneider
Clinic of Pediatric Hematology and Oncology, Heinrich Heine University, Medical Center, Dusseldorf, Germany
Klin Padiatr 213:204-11. 2001..As CGH does not require tissue culture, it also allows analysing archival tissue samples...
- Low expression of reduced folate carrier-1 and folylpolyglutamate synthase correlates with lack of a deleted in colorectal carcinoma mRNA splice variant in normal-appearing mucosa of colorectal carcinoma patientsYvonne Wettergren
Department of General Surgery, Sahlgrenska University Hospital Ostra, Goteborg University, S 416 85 Goteborg, Sweden
Cancer Detect Prev 29:348-55. 2005..The purpose of this study was to analyze if the folate level and the gene expression levels of reduced folate carrier (RFC-1) and folylpolyglutamate synthase (FPGS) had impact on the expression of DCC splice variants...
- Evidence that haploinsufficiency of Ptch leads to medulloblastoma in miceR H Zurawel
Department of Neurological Surgery, Mayo Clinic and Foundation, Rochester, Minnesota, USA
Genes Chromosomes Cancer 28:77-81. 2000..Expression of Gli1 was increased in tumors compared to normal cerebellum. These results suggest that deletion of one copy of Ptch may be sufficient to promote medulloblastoma development in mice...
- Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancerChunling Yi
Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
Mol Cell Biol 25:10052-9. 2005..These findings indicate that the 4.1B gene is not required for normal development and that 4.1B/Dal-1 does not function as a tumor suppressor gene...
- Antitumor effect of retinoic acid receptor-beta2 associated with suppression of cyclooxygenase-2Shumei Song
Department of Clinical Cancer Prevention, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Prev Res (Phila) 2:274-80. 2009..Thus, further studies will determine whether manipulation of COX-2 expression in different cancers can antagonize RAR-beta2 activity...
- Genetic aberrations common in gastric high-grade large B-cell lymphomaP Starostik
Institute of Pathology and Division of Medicine, Wuerzburg University, Wuerzburg, Germany
Blood 95:1180-7. 2000..Common genetic aberrations responsible for lymphomagenesis are deletions of 6q, loss of p53, and amplification of the 3q27 and the MLL gene regions. (Blood. 2000;95:1180-1187)..
- A dual-color FISH framework map for the characterization of the Sai1 tumor suppression region on rat chromosome 5K Helou
CMB Genetics, Lundberg Laboratory, Goteborg University, Goteborg, Sweden
Genes Chromosomes Cancer 27:362-72. 2000..1) and Cd30lg (5q24.3). The framework map will provide the basis for the detailed physical YAC clone contig mapping of this region, and facilitate the identification and characterization of the Sai1 locus...
- Molecular genetic parameters in pathogenesis and prognosis of testicular germ cell tumorsA Heidenreich
Department of Urology, Philipps University, Marburg, Germany
Eur Urol 37:121-35. 2000..and prognosis of testicular germ cell tumors will not only help to better understand development and progression of testicular cancer, but it will also define new approaches to classification and management of germ cell tumors..
- TCEAL7, a putative tumor suppressor gene, negatively regulates NF-kappaB pathwayR Rattan
Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA
Oncogene 29:1362-73. 2010....
- Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-betaO Cristina Micali
Department of Plant Microbe Interactions, Max Planck Institute for Plant Breeding Research, Koeln, Germany
BMC Cancer 7:52. 2007..In this report, we investigated the role of basal xaf1 promoter methylation in xaf1 expression and assessed the responsiveness of cancer cell lines to XAF1 induction by IFN-beta...
- 3p21, 5q21, 9p21 and 17p13.1 allelic deletions are potential markers of individuals with a high risk of developing adenocarcinoma in Barrett's epithelium without dysplasiaJulian Sanz-Ortega
Departamento de Anatomía Patológica Hospital Clinico San Carlos, Martin Lagos s n, Madrid, Spain 28040
Hepatogastroenterology 50:404-7. 2003..We investigated 32 cases of Barrett's esophagus with no evidence of dysplasia for LOH at 5q21 (APC), 3p21, 9p21 (p16) and 17p13.1 (p53) chromosomal regions...
- Localization and expression of p27KIP1 in multistage colorectal carcinogenesisM Ciaparrone
Centro di Ricerche Oncologicalhe Giovanni XXXIII Università Cattolica del Sacro Cuore, Rome, Italy
Cancer Res 58:114-22. 1998..This may reflect the existence of a homeostatic feedback mechanism that is lost in the high-grade carcinomas that express low levels of p27Kip1...
- Allelic losses at 1p36 and 19q13 in gliomas: correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor geneVioletta Barbashina
Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Clin Cancer Res 11:1119-28. 2005..To better define the histologic correlates of different patterns of 1p and 19q loss, we evaluated 1p/19q status in a large group of gliomas. This also allowed us to define a very small minimal deleted region (MDR) on 1p36...
- Assessment of NORE1A as a putative tumor suppressor in human neuroblastomaJanos Geli
Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital Solna, SE 171 76 Stockholm, Sweden
Int J Cancer 123:389-94. 2008..Promotor methylation is not a common mechanism responsible for NORE1A transcriptional suppression in this tumor type...
- Single nucleotide polymorphisms of IGFBP-3 gene and lung cancer risk in a Korean populationSle Gi Lo Han
Genomic Research Center for Lung and Breast Ovarian Cancers, Korea University Anam Hospital, Seoul, Republic of Korea
Lung Cancer 62:152-61. 2008..These results suggest that IGFBP-3 promoter polymorphisms of -1590 C>A and -202 A>C might be a genetic risk factor for lung cancer by means of decreased IGFBP-3 expression among females or never-smoking Koreans...
- Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formationFranco Capozza
Department of Molecular Pharmacology and The Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York, USA
Am J Pathol 162:2029-39. 2003..Our results provide the first genetic evidence that caveolin-1 indeed functions as a tumor suppressor gene in vivo...
- Hypoglycemia from IGF2 overexpression associated with activation of fetal promoters and loss of imprinting in a metastatic hemangiopericytomaElizabeth A Lawson
Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 94:2226-31. 2009..The mechanism of IGF2 overexpression in non-islet-cell tumor hypoglycemia is not understood...
- TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemiaJianhua Yu
Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
Blood 113:5558-67. 2009..Collectively, our data suggest that TSC-22 normally contributes to the regulation of HPC function and is a putative tumor suppressor gene that is hypermethylated and silenced in T or NK LGL leukemia...
- Putative tumor suppressor EDD interacts with and up-regulates APCRyuichi Ohshima
Division of Gastroenterological Surgery, Department of Surgery, St Marianna University School of Medicine, Kawasaki 216 8511, Japan
Genes Cells 12:1339-45. 2007..Thus, through protein-protein interaction, EDD stabilizes APC and up-regulates APC's function to inhibit beta-catenin, suggesting that EDD could act as a colorectal tumor suppressor...
- [Preparation of a novel telomerase inhibitory protein LPTS-L]Chu Wu
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Sheng Wu Gong Cheng Xue Bao 23:852-7. 2007..Through this study, a technique for preparation of LPTS-L protein in a large scale is established...
- Frequent loss of Dab2 protein and infrequent promoter hypermethylation in breast cancerSarangadhara Appala Raju Bagadi
Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
Breast Cancer Res Treat 104:277-86. 2007..Further, in silico analysis of Dab2 3'-UTR revealed existence of miRNA complimentary to this region of the gene, suggesting microRNA mediated targeting of Dab2 mRNA might account for loss of the protein in breast cancer...
- Identification and characterization of the murine TRPM4 channelManabu Murakami
Department of Pharmacology, Akita University School of Medicine, 1 1 1, Hondou, Akita 010 8543, Japan
Biochem Biophys Res Commun 307:522-8. 2003..Both TRPM4 variants integrated into the plasma membrane. Furthermore, FRET analysis revealed that TRPM4a and TRPM4b localized close together, suggesting a multimerization of the two molecules...
- Frequent epigenetic inactivation of the RASSF1A tumor suppressor gene in Hodgkin's lymphomaPaul G Murray
Department of Pathology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Oncogene 23:1326-31. 2004..Inactivation of RASSF1A could be one mechanism by which HRS cells escape the apoptosis that should occur following nonproductive immunoglobulin gene rearrangements...
- Genetic analysis identifies putative tumor suppressor sites at 2q35-q36.1 and 2q36.3-q37.1 involved in cervical cancer progressionGopeshwar Narayan
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
Oncogene 22:3489-99. 2003..Thus, these data identify frequent chromosomal amplifications in CC, and sites of TSGs at 2q35-q36.1 and 2q36.3-q37.1 that are critical in CC development...
- 3p21, 5q21, 9p21 and 17p13 allelic deletions accumulate in the dysplastic spectrum of laryngeal carcinogenesis and precede malignant transformationJ Sanz-Ortega
Department of Pathology, San Carlos Clinic Hospital, Madrid, Spain
Histol Histopathol 18:1053-7. 2003..These genomic changes in pre-malignant laryngeal lesions could be of potential use as markers for cancer risk assessment...
- Definition of a region of loss of heterozygosity at chromosome 11q23.3-25 in head and neck squamous cell carcinoma using laser capture microdissection techniqueDongfeng Tan
Department of Pathology, Roswell Park Cancer Institute, State University of New York at Buffalo, Buffalo, NY 14263, USA
Diagn Mol Pathol 13:33-40. 2004..3-25 was defined. LOH in this region may harbor putative tumor suppressor gene(s) critical for HNSCC. Furthermore, these allelic losses were not found in any non-neoplastic squamous tissue samples, clarifying prior discrepant data...
- Quantitative detection of promoter hypermethylation of multiple genes in the tumor, urine, and serum DNA of patients with renal cancerMohammad Obaidul Hoque
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, 720 Rutland Avenue, Baltimore, MD 21287, USA
Cancer Res 64:5511-7. 2004..This noninvasive high-throughput approach needs to be evaluated in large studies to assess its value in the early detection and surveillance of renal cancer...
- Down-regulation in human cancers of DRHC, a novel helicase-like gene from 17q25.1 that inhibits cell growthH Nagai
Department of Molecular Biology, Institute of Gerontology, Nippon Medical School 1 396, Kosugi cho, Nakahara ku, Kawasaki 211 0063, Japan
Cancer Lett 193:41-7. 2003..Transfection of a DRHC expression vector inhibited growth of cancer cells in liquid medium or soft agar. The results suggest that loss of expression of DRHC may play a role in human carcinogenesis...
- A 700-kb physical and transcription map of the cervical cancer tumor suppressor gene locus on chromosome 11q13Kayvan Zainabadi
Department of Surgery 10H2, VAGLAHS West Los Angeles, David Geffen School of Medicine, University of California at Los Angeles, Building 304, Room E2 218, 11301 Wiltshire Boulevard, West Los Angeles, CA 90073, USA
Genomics 85:704-14. 2005..The physical and transcription maps and the microsatellite markers of the 700-kb region of chromosome 11q13 should be helpful in the cloning of the cervical cancer tumor suppressor gene...
- beta-carotene-induced changes in RARbeta isoform mRNA expression patterns do not influence lung adenoma multiplicity in the NNK-initiated A/J mouse modelRegina Goralczyk
DSM Nutritional Products Ltd, Research and Development, Human Nutrition and Health, Basel, Switzerland
Nutr Cancer 54:252-62. 2006..Down-regulation of RARbeta in NNK-induced adenoma-bearing lungs was similar to that observed in human lung cancer and further confirms the A/J-mouse as a valuable model for lung carcinogenesis...
- An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosisLisa Y Zhao
Department of Anatomy and Cell Biology, Shands Cancer Center, University of Florida College of Medicine, Gainesville, FL 32611 3633, USA
Cancer Res 66:9445-52. 2006..Therefore, EBF3 regulates a transcriptional program underlying a putative tumor suppression pathway...
- Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanomaTamotsu Takeuchi
Department of Pathology, Kochi Medical School, Kochi, Japan
Am J Pathol 163:1395-404. 2003..The present findings suggest that skeletrophin may be a novel actin-binding cytoskeleton-related molecule, expression of which is silenced in a considerable number of melanoma specimens...
- PHF21B as a candidate tumor suppressor gene in head and neck squamous cell carcinomasFernanda Bernardi Bertonha
International Center of Research and Training CIPE, A C Camargo Cancer Center, Sao Paulo, SP 01 508 010, Brazil Electronic address
Mol Oncol 9:450-62. 2015..These data suggest that PHF21B is a novel tumor suppressor gene that can be inactivated by genetic and epigenetic mechanisms in the human cancer...
- Human/mouse microcell hybrid based elimination test reduces the putative tumor suppressor region at 3p21.3 to 1.6 cMA Szeles
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden
Genes Chromosomes Cancer 20:329-36. 1997..We have defined a common eliminated region of approximately 1.6 cM (designated as CER1) inside the 7 cM CER described earlier. CER1 is flanked distally by D3S1029 and proximally by D3S643...
- Overexpression of DOC-1R inhibits cell cycle G1/S transition by repressing CDK2 expression and activationQi Liu
The Research Center for Medical Genomics, MOH Key Laboratory of Cell Biology and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110001, China
Int J Biol Sci 9:541-9. 2013..In conclusion, the antitumor effects of DOC-1R may be mediated by negatively regulating G1 phase progression and G1/S transition through inhibiting CDK2 expression and activation...
- LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1)Hanbing An
Department of Otolaryngology, Vanderbilt University, Nashville, Tennessee, United States of America
PLoS ONE 6:e16427. 2011..Expression of LZAP increased both LZAP and Wip1 binding to p38. Taken together, these data suggest that LZAP activity includes inhibition of p38 phosphorylation and activation...
- CNT1 expression influences proliferation and chemosensitivity in drug-resistant pancreatic cancer cellsYangzom D Bhutia
Department of Phamaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia 30602, USA
Cancer Res 71:1825-35. 2011..In addition to supporting a putative tumor suppressor role for hCNT1, our findings identify hCNT1 as a potential candidate to render drug-resistant pancreatic cancer cells amenable to chemotherapy...
- Pharmacologic reversal of epigenetic silencing of the anticancer protein BRM: a novel targeted treatment strategyS Gramling
Division of Hematology Oncology, Department of Medicine, University of Florida, Gainesville, FL 32610, USA
Oncogene 30:3289-94. 2011..We therefore show, for the first time, that pharmacologic reversal of epigenetic changes of the SWI/SNF chromatic remodeling complex subunit, BRM, is a potentially viable and novel therapeutic approach...
- The putative tumor suppressor gene FHIT at 3p14.2 is rarely affected by loss of heterozygosity in primary human brain tumorsS Frank
Department of Surgical Research, Technical University of Dresden, Germany
Cancer Res 57:2638-41. 1997..In contrast, observed LOH rate for brain metastases was as high as 54.5% (n = 45), in accordance with data thus far accumulated from analyses of corresponding primary tumors...
- Isolation of 45 exon-like fragments from 8p22-->p21.3, a region that is commonly deleted in hepatocellular, colorectal, and non-small cell lung carcinomasK Chinen
Laboratory of Molecular Medicine, University of Tokyo, Japan
Cytogenet Cell Genet 75:190-6. 1996..The map and the exon-like fragments reported here will be useful resources for isolation of the putative tumor suppressor gene(s) as well as other novel genes located in the 8p22-->p21.3 region...
- Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitroTingting Qiu
Leukemia Research Unit, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Jiangsu Institute of Hematology, First Afﬁliated Hospital, Soochow University, Suzhou 215006, PR China
Oncol Rep 28:622-8. 2012..In conclusion, these results demonstrated that Rap1GAP promoted leukemia cell differentiation and apoptosis, but increased leukemia cell invasion in vitro...
- Genetic polymorphism of PRKCDBP is associated with an increased risk of endometrial cancerSeo Yun Tong
Department of Obstetrics and Gynecology, School of Medicine, Kyung Hee University, Seoul, South Korea
Cancer Invest 30:642-5. 2012..Allele frequencies in the cancer specimens were compared with those in the healthy controls. We also evaluated the association between polymorphisms at this locus and histopathological features of endometrial cancer...
- Epigenetic silencing of Aristaless-like homeobox-4, a potential tumor suppressor gene associated with lung cancerWen Bin Liu
Institute of Toxicology, College of Preventive Medicine, Third Military Medical University, Chongqing, China Key Laboratory of Medical Protection for Electromagnetic Radiation, Ministry of Education of China, Chongqing, China
Int J Cancer 134:1311-22. 2014..In conclusion, our results suggest that ALX4 is a novel putative tumor suppressor with epigenetic silencing in lung carcinogenesis. ..
- A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagusDavid M Levine
Department of Biostatistics, University of Washington, School of Public Health, Seattle, Washington, USA
Nat Genet 45:1487-93. 2013..We also refine a previously reported association with Barrett's esophagus near the putative tumor suppressor gene FOXF1 at 16q24 and extend our findings to now include esophageal adenocarcinoma. ..
- The link between MHC class I abnormalities of tumors, oncogenes, tumor suppressor genes, and transcription factorsBarbara Seliger
Institute of Medical Immunology, Martin Luther University Halle Wittenberg, Halle, Germany
J Immunotoxicol 11:308-10. 2014....
- GCIP functions as a tumor suppressor in non-small cell lung cancer by suppressing Id1-mediated tumor promotionKuan Yu Chen
Institute of Biotechnology, National Cheng Kung University, Tainan, Taiwan
Oncotarget 5:5017-28. 2014..Taken together, these results suggest that GCIP is a potential tumor suppressor in NSCLC and that suppression of Id1-mediated oncogenic properties may be a key mechanism by which GCIP can potently suppress NSCLC tumor progression. ..
- The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancersH Aberle
Max Planck Institut für Immunobiologie, Freiburg, Germany
Proc Natl Acad Sci U S A 92:6384-8. 1995..Our results, together with the present knowledge about the biological function of plakoglobin, suggest that plakoglobin might represent a putative tumor suppressor gene for breast and ovarian cancers...
- Epigenetic silencing of the non-coding RNA nc886 provokes oncogenes during human esophageal tumorigenesisHyun Sung Lee
Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA Center for Lung Cancer, Research Institute and Hospital, National Cancer Center, Goyang, 410 769, Korea
Oncotarget 5:3472-81. 2014..All these findings implicate nc886 as a novel, putative tumor suppressor that is epigenetically silenced and regulates the expression of oncogenes in ESCC. ..
- Tissue factor pathway inhibitor 2 (TFPI2) is frequently silenced by aberrant promoter hypermethylation in gastric cancerHisashi Takada
Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan
Cancer Genet Cytogenet 197:16-24. 2010..Aberrant methylation of TFPI2 promoter CpG island occurred not only in GC cells but also in primary GC tissues at a high frequency, suggesting that epigenetic silencing of TFPI2 may contribute to gastric carcinogenesis...
- Abnormalities of fragile histidine triad genomic and complementary DNAs in cervical cancer: association with human papillomavirus typeC Y Muller
Department of Obstetrics and Gynecology, Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas 75235 9032, USA
J Natl Cancer Inst 90:433-9. 1998..We examined abnormalities in FHIT and its RNA transcripts in cervical cancer cell lines and tumors. We also investigated the relationship between loss of heterozygosity (LOH) in FHIT/FRA3B and the presence of oncogenic HPV types...
- S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesisJ F Leal
Spanish National Cancer Research Center CNIO, 3 Melchor Fernández Almagro St, Madrid 28029, Spain
Carcinogenesis 29:2089-95. 2008..Moreover, SAHH protein was also affected in some colon cancers. Such findings may be of relevance to cancer research, suggesting that SAHH might be a largely unexplored tumor suppressor...
- Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancerHideki Yamada
Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
Genes Chromosomes Cancer 47:810-8. 2008..In addition, initial attempts were made to investigate their potential alterations and functional involvements in the development of lung cancer...
- Frequent allelic loss on chromosome 9 in hepatocellular carcinomaC T Liew
Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Faculty of Medicine, Chinese University of Hong Kong, Shatin
Int J Cancer 81:319-24. 1999..Our data also suggest that inactivation of the p16 and the p15 genes and the possibility of other unknown tumor-suppressor genes located on these defined deleted regions of chromosome 9 may be involved in the pathogenesis of HCC...
- High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarrayDong Yin
Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, Davis Building 5022 Room, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
Mol Cancer Res 7:665-77. 2009..1 (p53) deletion/AUPD. Taken together, these results suggest that this technique is a rapid, robust, and inexpensive method to profile genome-wide abnormalities in GBM...
- Expression of BRCA1 and BRCA2 in normal and neoplastic cellsL A Chodosh
Department of Molecular and Cellular Engineering, University of Pennsylvania School of Medicine, Philadelphia 19104 6100, USA
J Mammary Gland Biol Neoplasia 3:389-402. 1998..These observations have contributed to the emerging hypothesis that these genes function in similar regulatory pathways...
- Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinomaErina Nakamura
Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima Bunkyo ku, Tokyo 113 8510, Japan
Cancer Sci 99:1390-400. 2008....
- IGFBP-3 expression in hepatocellular carcinoma involves abnormalities in TGF-beta and/or Rb signaling pathwaysEiichiro Yumoto
Department of Medicine, Okayama University Graduate School of Medicine and Dentistry, Japan
Int J Oncol 27:1223-30. 2005..The present study suggests that IGFBP-3 mediates growth suppression signals via the TGF-beta and/or Rb pathways in HCC...
- Radiation carcinogenesis: lessons from ChernobylD Williams
Christ s College, University of Cambridge, Cambridge, UK
Oncogene 27:S9-18. 2008..The type and molecular pathology of the thyroid tumors is changing with increasing latency, long latency tumors in other organs could occur in the future. A comprehensive follow up must continue for the lifetime of those exposed...
- Repression of estrogen receptor beta function by putative tumor suppressor DBC1Satoshi Koyama
Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo 113 8655, Japan
Biochem Biophys Res Commun 392:357-62. 2010..These results implicate the principal role of DBC1 in regulating ERbeta-dependent gene expressions...
- Changes in CpG islands promoter methylation patterns during ductal breast carcinoma progressionMohammad Obaidul Hoque
Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Cancer Epidemiol Biomarkers Prev 18:2694-700. 2009....
- Senescence induction; a possible cancer therapyMatilde E Lleonart
Pathology Department, Fundació Institut de Recerca Hospital Vall d Hebron, Passeig Vall d Hebron 119 129, 08035 Barcelona, Spain
Mol Cancer 8:3. 2009..These findings offer new perspectives in the modulation of senescence and open new approaches for cancer therapy...
- Frequent epigenetic inactivation of hSRBC in gastric cancer and its implication in attenuated p53 response to stressesJin Hee Lee
School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
Int J Cancer 122:1573-84. 2008..Our findings suggest that hSRBC is a novel tumor suppressor whose epigenetic inactivation contributes to the malignant progression of gastric tumors, in part, through attenuated p53 response to stresses...
- The dependence receptors DCC and UNC5H as a link between neuronal guidance and survivalPatrick Mehlen
Apoptosis Differentiation Laboratory, Equipe labellisée, Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France
Biol Cell 95:425-36. 2003..We then conclude to the possible roles of DCC and UNC5H pro-apoptotic activities in both nervous system development and tumorigenesis...
- Disruption of MKK4 signaling reveals its tumor-suppressor role in embryonic stem cellsMichele Cazillis
1INSERM U 481, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, BP 416, 75870 Paris 18, France
Oncogene 23:4735-44. 2004..Taken together, our data provide a new mechanism linking the MKK4 signaling pathways to cancer progression and identify MKK4 as a tumor-suppressor gene implicated in several transforming functions...
- The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defectTingting Zhang
The Institute of Radiation Medicine, Fudan University, Shanghai, China
Int J Radiat Biol 91:368-78. 2015..In this study, we investigated how DAB2IP knockdown influenced BCa cell response to ionizing radiation (IR) and discussed possible ways to enhance cell radiosensitivity...
- Cigarette smoke induces methylation of the tumor suppressor gene NISCHKimberly Laskie Ostrow
Department of Otolaryngology Head and Neck Cancer Research Division Johns Hopkins School of Medicine Baltimore, MD USA
Epigenetics 8:383-8. 2013....
- Reprimo (RPRM) is a novel tumor suppressor in pituitary tumors and regulates survival, proliferation, and tumorigenicityMei Xu
Department of Medicine, Physiology, and Biophysics, University of Colorado Denver, Aurora, Colorado 80045, USA
Endocrinology 153:2963-73. 2012..When RPRM is silenced as in human pituitary tumors, unrestrained growth and tumor progression may occur...
- Fine-scale deletion mapping of the distal long arm of chromosome 6 in 70 human ovarian cancersS Saito
Department of Biochemistry, Cancer Institute, Tokyo, Japan
Cancer Res 52:5815-7. 1992..9 cM apart on the basis of linkage analysis. Our results further define a region containing a tumor suppressor gene involved in ovarian carcinoma within an approximately 2-megabase-long segment of chromosome 6q...
- GTPase regulator associated with the focal adhesion kinase (GRAF) transcript was down-regulated in patients with myeloid malignanciesZhen Qian
Department of Hematology, Affiliated People s Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, China
J Exp Clin Cancer Res 29:111. 2010..The aim of this study was to investigate the expression level of GRAF gene in those patients with myeloid malignancies including acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) and chronic myeloid leukemia (CML)...
- RNA binding motif (RBM) proteins: a novel family of apoptosis modulators?Leslie C Sutherland
Tumour Biology Group, Northeastern Ontario Regional Cancer Centre, 41 Ramsey Lake Road, Sudbury, Ontario P3E 5J1, Canada
J Cell Biochem 94:5-24. 2005..It is the intent of this article to ammalgamate the data on the ten originally identified RBM proteins in order to question the existence of a novel family of RNA binding apoptosis regulators...
- DNA methylation pattern of the SLC25A43 gene in breast cancerBreezy Malakkaran Lindqvist
School of Health and Medical Sciences, Orebro University, Orebro, Sweden
Epigenetics 7:300-6. 2012..Also, associations between site-specific methylation and clinicopathological parameters suggest that epigenetic changes in SLC25A43 gene could be of importance in breast carcinogenesis...
- Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomasDo Sun Byun
Department of Pathology, School of Medicine, Kyung Hee University, Seoul 130 701, Korea
Cancer Res 63:7068-75. 2003..Collectively, our study suggests that epigenetic silencing of XAF1 by aberrant promoter methylation may contribute to the malignant progression of human gastric tumors...
- The tumor suppressor PRDM5 regulates Wnt signaling at early stages of zebrafish developmentNatalia Meani
Department on Experimental Oncology, European Institute of Oncology, Milan, Italy
PLoS ONE 4:e4273. 2009..Our data demonstrate that PRDM5 regulates the expression of components of both canonical and non canonical wnt pathways and negatively modulates wnt signaling in vivo...
- Clinical significance of altered S100A2 expression in gastric cancerYing Zhao
Department of General Surgery, Shengjing Hospital of China Medical University, and Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, Liaoning 110004, PR China
Oncol Rep 29:1556-62. 2013....
- Loss of FHIT expression in breast cancer is correlated with poor prognostic markersBanu Arun
Division of Hematology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard 424, Houston, TX 77030, USA
Cancer Epidemiol Biomarkers Prev 14:1681-5. 2005....
- IL-15 Characterization Through Experimental ImmunologyMichael A Caligiuri; Fiscal Year: 2013..Funding of this proposal will advance our understanding of basic immunology as well as strategies to prevent and treat cancer. ..
- MOLECULAR PROGRESSION MODEL FOR HNSCCDavid Sidransky; Fiscal Year: 2012..These early molecular events will be identified and developed as targets for early detection and staging approaches, with emphasis on molecular detection strategies amenable to rapid, automated application. ..
- TUMOR SUPPRESSOR GENES IN HUMAN THYROID NEOPLASMSJames Fagin; Fiscal Year: 1990....
- ISOLATION OF TUMOR SUPPRESSOR GENES IN RHABDOMYOSARCOMAMary Sugrue; Fiscal Year: 2000..Selection of RD transfectants based on induction of a growth- inhibited or differentiated phenotype will be attempted. 3) Molecular characterization of putative tumor suppressor gene(s). ..
- ALLELE LOSS IN THE GENESIS OF GASTRIC CANCERBarbara Schneider; Fiscal Year: 1999..Since these proteins are likely to participate critically in reducing cell proliferation the study of each of them holds the potential to reveal more specific therapies for cancer. ..
- Characterization of Human 3p Recessive OncogenesJohn Minna; Fiscal Year: 2004..mutation, suppression of the malignant phenotype) including CACNA2D2, 101F6, NPR21/G21, BLU, FUSI, HYAL1, and FUS2. The current proposal will: Confirm the tumor suppressing function of RASSF1A and SEMA3B and further implicate or ..
- Detection of Novel Gene Defects in Basal Cell CarcinomaSteven Fakharzadeh; Fiscal Year: 2005..abstract_text> ..
- Use of RNAi to investigate cullin-5 function in breast cancerMichael Fay; Fiscal Year: 2006..A better understanding of cancer-related genes, such as Cul5, is expected to lead to better therapies for patients. [unreadable] [unreadable] [unreadable] [unreadable]..
- CLONING A GENE AT 12Q22 DELETION IN GERM CELL TUMORSMurty Vundavalli; Fiscal Year: 2001..Subsequently, the TSG will be characterized as to its evolutionalry conservation, genomic organization, normal function, and specific role in tumorigenesis. ..
- STATISTICAL METHODS FOR MOLECULAR CANCER DATAMichael Newton; Fiscal Year: 1999..Computer simulation of the model will be useful both to study bias and variance properties of the proposed methods and as the basis for power calculations to design marker studies. ..
- SIGNIFICANCE OF ALLELIC DELETIONS IN NEUROBLASTOMAJohn Maris; Fiscal Year: 1999..These studies should also substantially contribute towards the positional cloning of three neuroblastoma suppressor genes and our basic understanding of the molecular genetics of this common pediatric tumor. ..
- SIGNALING MECHANISM IN DCC-INDUCED APOPTOSISYong Chen; Fiscal Year: 2003....
- Role of POZ-zinc finger proteins in tumorigenesis.Pier Paolo Pandolfi; Fiscal Year: 2013..In view of the critical role exerted by this protein in tumorigenesis and embryonic development the further elucidation of POKEMON/LRF function and role in human cancer is of great relevance to biomedical research. ..
- Regulation of Pancreatic Tumor Progression by Disabled-2Barbara A Hocevar; Fiscal Year: 2010..The studies proposed here will provide prelimary evidence to support a role of Disabled-2 in prevention of pancreatic tumor progression and metastasis which may lead to improved diagnosis and treatment of pancreatic cancer. ..
- Colorectal Cancer Prevention Through Thyroid Hormone TargetsADAM ROBERT BROWN; Fiscal Year: 2013..The successful completion of the study will provide insight into potential age-dependent targets that may lead to the development of new therapies to prevent or treat age-related colorectal cancer. ..
- Investigation of Notch-inhibiting microRNAs in gliomaBenjamin W Purow; Fiscal Year: 2013..In this proposal, we will investigate two microRNAs as tumor suppressors and therapies in glioma secondary to their inhibition of the Notch pathway, a central pathway in stem cells, cell fate, and cancer. ..
- A new regulator for Wnt/beta-catenin signaling and prostate tumorigenesisZijie Sun; Fiscal Year: 2013..Insights into new diagnostic markers, therapeutic targets and approaches for prostate cancer and other tumors are expected. ..
- Role of the Putative Tumor Suppressor PinX1 in the Etiology of Liver CancerXiao Zhen Zhou; Fiscal Year: 2010..These studies would establish new animal models for studying liver cancer and provide novel insight into the etiology and treatment of liver cancer. ..
- Role of TET2 in normal hematopoiesis and pathogenesis of myeloid malignanciesMingjiang Xu; Fiscal Year: 2013..The Tet2 murine models also offer a biological context in which drugs and other therapies can be tested and developed. ..
- Semaphorin 3F: Structure, Function, and Anti-Metastatic ActivityDiane Renee Bielenberg; Fiscal Year: 2010..Most of all, a Howard Temin Award would enable the continuation of this research project toward the ultimate goal of long-term stable disease. ..
- Role of NIAM, A Putative Cancer Gene, in Chromosomal Instability and GlioblastomaSARA MARIE FRANCIS-REED; Fiscal Year: 2013..My ultimate goal is to become an independent physician scientist studying pediatric cancers. I am excited that this training experience will effectively prepare me for such a career in translational cancer research. ..
- LCM Analysis and Mouse Models to Validate miRs in Prostate Tumor ProgressionZENDRA ELIZABETH ZEHNER; Fiscal Year: 2012....
- KLF4 Genetic and Epigenetic Changes in Human Pancreatic CancerKeping Xie; Fiscal Year: 2012..However, the critical role of KLF4 signaling in human cancer development and progression in general and human pancreatic cancer in particular is unclear. ..
- CORRELATIVE STUDIES USING SPECIMENS FROM SWOG 9321John Shaughnessy; Fiscal Year: 2000..Specific Aim 3: Evaluate whether chromosome 13 deletions correlate with clinical outcome (complete remission, event free survival, and overall survival). ..
- CLONING NOVEL GENES FOR PAGETS DISEASE AND OSTEOSARCOMAMarc Hansen; Fiscal Year: 2001....
- MECHANISMS OF ENZYMATIC REACTIONSPERRY FREY; Fiscal Year: 2006..unreadable] [unreadable]..
- BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIAJoseph Wiemels; Fiscal Year: 2006..We are ultimately working to elucidate the origin and causes of a cancer that might be preventable. [unreadable] [unreadable]..
- SUPPRESSION OF TUMOR PROGRESSION BY CONNEXIN 43Shu Chih Chen; Fiscal Year: 2000....
- DNA METHYLATION AND SOD2/MNSOD GENE EXPRESSIONFrederick Domann; Fiscal Year: 2002..A better understanding of the mechanisms of regulation of the expressio of SOD2 during carcinogenesis and differentiation may lead to new strategies for the treatment of diseases in which aberrant SOD2 expression plays a key role. ..
- Characterization of HIN1 Putative Tumor SuppressorIan Krop; Fiscal Year: 2003..The results of these studies will thus determine the role of HIN-1 as a potential tumor suppressor gene and, since it is inactivated frequently in early BC, may provide an excellent target for preventive intervention. ..
- Function and Regulation of Pin2/TRF1 and PinX1Kun Ping Lu; Fiscal Year: 2005..These studies should yield new insights into telomere maintenance, cell growth control and oncogenesis, and may lead to the development of new anticancer therapy. ..
- METABOLISM AND TOXICITY OF HYDROQUINONE-THIOETHERSSerrine Lau; Fiscal Year: 2003..The overall goals of this aim are to characterize the Eker animal model in which the effects of environmental influences (chemical exposure) on a genetic predisposition to cancer are determined. ..
- Identification of Receptor for Tumor Suppressor HIN-1Dale Porter; Fiscal Year: 2003..abstract_text> ..
- MOLECULAR ANALYSIS OF THE DEL(20Q) IN MYELOID LEUKEMIASMICHELLE LE BEAU; Fiscal Year: 2003..abstract_text> ..
- MAPPING GENETIC SUPPRESSORS OF EPIGENETIC CARCINOGENESISHelmut Zarbl; Fiscal Year: 2002....
- PinX1, a Putative Tumor Suppressor for Prostate CancerXiao Zhou; Fiscal Year: 2004..Furthermore, these pilot studies are novel and will serve as the first step in obtaining R01 support from NIH to start a new project on prostate cancer. ..
- DNA polymerase iota as a putative tumor suppressorWilliam G McGregor; Fiscal Year: 2010..The ultimate goal of this research is to understand how carcinogens cause cancer in order to design strategies to prevent the disease. ..
- DNA methylation patterns as biomarker for breast cancerKristin Skinner; Fiscal Year: 2003..These future studies will determine whether DNA methylation changes can be used a) to stratify women at risk for breast cancer and b) as a surrogate endpoint in chemoprevention trials. ..
- CELL CYCLE REGULATORS OF ORAL CANCERJAMES RHEINWALD; Fiscal Year: 2002..These Cores will also validate conclusions from the research projects in human oral cancer tissues. ..
- Regulation of Bcl2 Function Via Ceramide-Activated PP2APeter Ruvolo; Fiscal Year: 2006..From these results, it is expected that the development of novel anticancer strategies that target mechanisms regulating Bc12 function will occur...
- BRCA1 AND DIFFERENTIATION AND ENDOCRINE RISK FACTORLewis Chodosh; Fiscal Year: 2000..Ultimately, understanding the role played by BRCA1 in the regulation of these processes has the potential to lead to novel strategies for the prevention and treatment of breast cancer. ..
- CHROMOSOME 9P ABERRATIONS IN GLIOMADennis Carson; Fiscal Year: 1999....
- Genetic Modifiers of p53Susan Evans; Fiscal Year: 2005..abstract_text> ..
- EXPRESSION AND FUNCTION OF CUL 5/VACM 1 IN BREAST CANCERMichael Fay; Fiscal Year: 2000..abstract_text> ..
- LYSYL OXIDASE GENE MUTATIONS IN COLON CANCERKatalin Csiszar; Fiscal Year: 2001..This proposal seeks to characterize these 5q23 rearrange- ments in order to begin to understand the role of lysyl oxidase gene mutations in the cascade of genetic events that lead to colorectal tumorigenesis. ..
- DOC-1R, A NOBEL CDK2-ASSOCIATED PROTEINXue Zhang; Fiscal Year: 2000..The long term goal of this proposal is to substantiate the role of DOC-1R as a new CDK2 regulatory protein, in the regulation of CDK2-mediated cell cycle biology in normal and tumor development. ..
- APC2 AND BREAST CANCERStephen Byers; Fiscal Year: 2002..Targets of beta-catenin signaling include cyclin Dl and c-myc, both of which are commonly overexpressed in human breast cancers. We will relate the cytogenetics of APC2 to the expression of cyclin D1 and c-myc breast cancers. ..
- Influence of ErbB4 activity on metastatic breast cancerFrank Jones; Fiscal Year: 2007..abstract_text> ..
- Chemoprevention of Oral Dysplasia by Black RaspberriesSusan Mallery; Fiscal Year: 2005..This experimental design (comparison of pretreatment and post-treatments tissues) permits each patient to serve as their own internal control. ..
- Formulation & Evaluation of Bioadhesive Gels for Oral Cancer ChemopreventionSusan Mallery; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Temporal Analysis of Mammary CarcinogenesisLewis Chodosh; Fiscal Year: 2005....
- Mammary Development and Breast Cancer SusceptibilityLewis Chodosh; Fiscal Year: 2005..We anticipate that these studies will help to illuminate developmental mechanisms that contribute to the determination of breast cancer susceptibility. ..
- BRCA2 FUNCTION IN MAMMARY EPITHELIAL BIOLOGYLewis Chodosh; Fiscal Year: 2002..We will also determine whether Brca2 is posttranslationally modified following DNA damage in a manner similar to that observed for Brca1. Finally, we will determine whether Brca2 and Brca1 interact during these processes. ..
- PARADIGM OF MULTISTEP URINARY BLADDER CARCINOGENESISBogdan Czerniak; Fiscal Year: 2006....
- Biomarker modulation/COX-2 inhibitor/Breast CancerBanu Arun; Fiscal Year: 2003..Ultimately, the development of non-hormonal chemoprevention agents, and identification of surrogate markers will allow us to plan large-scale, phase III chemoprevention studies with the endpoint of cancer incidence. ..
- P27Kipl deficiency, potential promoter of carcinogenesisKonstantin Christov Tzelkov; Fiscal Year: 2003..abstract_text> ..
- TOPOISOMERASES IN RETINOID INDUCED DIFFERENTIATIONAndrew Yen; Fiscal Year: 2003..Andrew Yen, who brings expertise on the molecular and cellular biology of retinoic acid-induced myeloid differentiation. ..
- HUNK AND PUNC FUNCTION IN MAMMARY EPITHELIAL BIOLOGYLewis Chodosh; Fiscal Year: 2004....
- FLUORESCENCE ACTIVATED CELL SORTERAndrew Yen; Fiscal Year: 2004..The instrument requested is a Dako-Cytomation basic MoFlo plus a UV-vis, vis, and HeNe laser to provide independent UV, vis/488, and red excitation. ..
- ROLE OF FRAGILE SITES IN CHROMOSOME BREAKAGE AND CANCERThomas Glover; Fiscal Year: 2008..unreadable] [unreadable]..
- Conference Proposal: Calcium and Cell FunctionCraig Montell; Fiscal Year: 2004..The topics to be covered at the meeting are of fundamental importance and are relevant to understanding the bases of a diseases such as neurodegeneration, communicative disorders, aging, cancer, kidney and cardiovascular disease. ..
- Role of Oxidants & Angiogenesis in Kaposi's SarcomaSusan Mallery; Fiscal Year: 2007..Elucidation of these interactions will not only clarify KS pathogenic mechanisms, but will also identify sites for KS therapeutic intervention. ..
- Retinoic Acid Regulated Cell Differentiation: BLR1 RcptrAndrew Yen; Fiscal Year: 2005..It has the implication that the ultimate effects of RA can be governed by relevant growth factors signaling through their cognate receptors. ..
- Mechanisms of Progression in c-MYC-Induced Breast CancerLewis Chodosh; Fiscal Year: 2006..abstract_text> ..
- FOXC2 in Hereditary Lymphedema and Lymphatic DevelopmentThomas Glover; Fiscal Year: 2007..abstract_text> ..