NAT10

Summary

Gene Symbol: NAT10
Description: N-acetyltransferase 10
Alias: ALP, NET43, RNA cytidine acetyltransferase, 18S rRNA cytosine acetyltransferase, N-acetyltransferase 10 (GCN5-related), N-acetyltransferase-like protein
Species: human

Top Publications

  1. doi Structural basis and specificity of human otubain 1-mediated deubiquitination
    Mariola J Edelmann
    Henry Wellcome Building for Molecular Physiology, Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX37BN, UK
    Biochem J 418:379-90. 2009
  2. ncbi Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT
    Junjie Lv
    Department of Pathology, Health Science Center of Peking University, 38 Xueyuan Road, Haidian District, Beijing 100083, China
    Biochem Biophys Res Commun 311:506-13. 2003
  3. ncbi DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation
    Haijing Liu
    Department of Pathology, Health Science Center of Peking University, 38 Road Xueyuan, Haidian District, Beijing 100083, China
    Mol Cell Biochem 300:249-58. 2007
  4. ncbi Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Biol Chem 282:27447-58. 2007
  5. doi GSK-3β-regulated N-acetyltransferase 10 is involved in colorectal cancer invasion
    Hong Zhang
    Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    Clin Cancer Res 20:4717-29. 2014
  6. pmc Human NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA)
    Satoshi Ito
    From the Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656 and
    J Biol Chem 289:35724-30. 2014
  7. pmc Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
    Dragony Fu
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3200, USA
    Mol Cell 28:773-85. 2007
  8. ncbi [Nucleolar localization of human acetyltransferase-like protein and its expression in tumors]
    Li zhao Guan
    Department of Pathology, Peking University School of Basic Medical Sciences, Beijing, China
    Beijing Da Xue Xue Bao 40:347-51. 2008
  9. doi NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules
    Qi Shen
    Department of Pathology, Health Science Center of Peking University, Haidian District, Beijing, China
    Exp Cell Res 315:1653-67. 2009
  10. ncbi Serum transferrin as a marker of bone growth in boys: correlation with serum alkaline phosphatase activity, plasma insulin-like growth factor 1 and rate of growth in height
    M Misaki
    Student Health Center, Mie University, Tsu, Japan
    Horm Metab Res 23:230-2. 1991

Research Grants

  1. STEVEN R MUMM; Fiscal Year: 2014
  2. Xianzhong Meng; Fiscal Year: 2015
  3. Purinergic receptors in inflammation
    Wolfgang G Junger; Fiscal Year: 2012
  4. MINERALIZATION STUDIES RELATED TO ORAL BIOLOGY
    HARRISON ANDERSON; Fiscal Year: 2005
  5. MOLECULAR BASIS OF PRONEPHRIC DUCT CELL GUIDANCE
    MALCOLM STEINBERG; Fiscal Year: 1991
  6. GROWTH FACTORS AND SKELETAL AGING
    Theresa Chen; Fiscal Year: 2000
  7. Xiaobin Wang; Fiscal Year: 2014
  8. Francesca Tentori; Fiscal Year: 2015
  9. Kelly A Birdwell; Fiscal Year: 2015
  10. Effects of resistant starch on lipid and glucose metabolism in insulin resistance
    RONALD M contact KRAUSS; Fiscal Year: 2010

Detail Information

Publications258 found, 100 shown here

  1. doi Structural basis and specificity of human otubain 1-mediated deubiquitination
    Mariola J Edelmann
    Henry Wellcome Building for Molecular Physiology, Department of Clinical Medicine, University of Oxford, Roosevelt Drive, Oxford OX37BN, UK
    Biochem J 418:379-90. 2009
    ....
  2. ncbi Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT
    Junjie Lv
    Department of Pathology, Health Science Center of Peking University, 38 Xueyuan Road, Haidian District, Beijing 100083, China
    Biochem Biophys Res Commun 311:506-13. 2003
    ..The investigation suggested that hALP influences the activity of histone acetylation and could up-regulate telomerase activity through transactivation of hTERT promoter...
  3. ncbi DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation
    Haijing Liu
    Department of Pathology, Health Science Center of Peking University, 38 Road Xueyuan, Haidian District, Beijing 100083, China
    Mol Cell Biochem 300:249-58. 2007
    b>NAT10 (N-acetyltransferase 10) is a protein with histone acetylation activity and primarily identified to be involved in regulation of telomerase activity...
  4. ncbi Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Biol Chem 282:27447-58. 2007
    ..We propose that nascently reforming nuclear envelope employs hsSUN1 and hALP to acetylate histones for de-compacting DNA at the end of mitosis...
  5. doi GSK-3β-regulated N-acetyltransferase 10 is involved in colorectal cancer invasion
    Hong Zhang
    Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    Clin Cancer Res 20:4717-29. 2014
    b>NAT10 (N-acetyltransferase 10) is a nucleolar protein, but may show subcellular redistribution in colorectal carcinoma...
  6. pmc Human NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation in 18 S ribosomal RNA (rRNA)
    Satoshi Ito
    From the Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656 and
    J Biol Chem 289:35724-30. 2014
    Human N-acetyltransferase 10 (NAT10) is known to be a lysine acetyltransferase that targets microtubules and histones and plays an important role in cell division...
  7. pmc Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation
    Dragony Fu
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3200, USA
    Mol Cell 28:773-85. 2007
    ..Curiously, overexpression of either associated hnRNP protein (hnRNP C and hnRNP U) or either NTPase protein (NAT10 and GNL3L) induced telomere shortening...
  8. ncbi [Nucleolar localization of human acetyltransferase-like protein and its expression in tumors]
    Li zhao Guan
    Department of Pathology, Peking University School of Basic Medical Sciences, Beijing, China
    Beijing Da Xue Xue Bao 40:347-51. 2008
    ..To confirm the nucleolar localization of telomerase-regulation associated protein-human N-acetyltransferase-like protein (hALP) and its associated functions...
  9. doi NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules
    Qi Shen
    Department of Pathology, Health Science Center of Peking University, Haidian District, Beijing, China
    Exp Cell Res 315:1653-67. 2009
    ..In this study, we demonstrated that NAT10 (N-acetyltransferase 10, NAT10) is not only predominantly distributed in the nucleolus in interphase, but is also ..
  10. ncbi Serum transferrin as a marker of bone growth in boys: correlation with serum alkaline phosphatase activity, plasma insulin-like growth factor 1 and rate of growth in height
    M Misaki
    Student Health Center, Mie University, Tsu, Japan
    Horm Metab Res 23:230-2. 1991
    ..The aim of this work was to study possible relationships between serum TF, alkaline phosphatase activity (ALP), plasma insulin-like growth factor 1 (IGF-1) levels and rate of height increase in boys...
  11. ncbi Effect of aminohydroxypropylidene diphosphonate on the bone metabolism of patients with parathyroid adenoma
    E Ishimura
    Second Department of Internal Medicine, Osaka City University Medical School, Japan
    Horm Metab Res 25:493-7. 1993
    ..Serum alkaline phosphatase (ALP) and osteocalcin, markers of osteoblast activity, decreased after APD administration...
  12. ncbi Dose-dependent renal tubular toxicity of harman and norharman in male F344 rats
    A Hagiwara
    First Department of Pathology, Nagoya City University Medical School, Japan
    Toxicol Pathol 20:197-204. 1992
    ..levels were increased, and the brush border enzymes (gamma-glutamyl transpeptidase, GGT, and alkaline phosphatase, ALP) decreased...
  13. ncbi Raised plasma concentrations of parathyroid hormone related peptide in hypercalcemic multiple myeloma
    T Horiuchi
    Section of Endocrinology, Tokyo Metropolitan Geriatric Hospital, Japan
    Horm Metab Res 29:469-71. 1997
    ..We also measured serum levels of inorganic phosphorus (iP) and alkalinephosphatase activity (ALP). No significant differences in iP (3.2 +/- 0.4 vs. 4.0 +/- 2.2 mg/dl), ALP (150 +/- 28 vs...
  14. ncbi Association between parathyroid hormone (PTH)/PTH-related peptide receptor gene polymorphism and the extent of bone mass reduction in primary hyperparathyroidism
    M Kanzawa
    Department of Medicine, Kobe University School of Medicine, Japan
    Horm Metab Res 32:355-8. 2000
    ..before and one year after parathyroidectomy, as well as serum levels of calcium, phosphorus, alkaline phosphatase (ALP) and intact PTH were measured...
  15. ncbi The usefulness of biochemical bone markers in predicting the response of hormone replacement therapy in perimenopausal cigarette smoking healthy women
    M Cubrilo-Turek
    Clinics for Internal Medicine, General Hospital Sveti Duh, Zagreb, Croatia
    Coll Antropol 23:195-201. 1999
    ..in hormone replacement users (N = 35) and non-users (N = 28): serum total calcium (Ca), total alkaline phosphatase (ALP), procollagen I C-terminal propeptide (PICP), cros-linked carboxyterminal collagen I telopeptide (ICTP) and ..
  16. ncbi Reduced expression of platelet endothelial cell adhesion molecule-1 in bone marrow cells in mice after skeletal unloading
    Miyuki Sakuma-Zenke
    Department of Orthopaedic Surgery, University of Occupational and Environmental Health, Iseigaoka, Kitakyushu, Japan
    J Bone Miner Res 20:1002-10. 2005
    ..Anti-PECAM-1 antibody suppressed both ALP+ CFU-f formation and ALP production under co-culture of the osteoblastic cell line and the PECAM-1+ endothelial ..
  17. ncbi [A case of AIDS complicated with liver tuberculosis]
    I Kawashima
    Department of Internal Medicine, Kawasaki Municipal Hospital
    Kansenshogaku Zasshi 74:984-8. 2000
    ..historicica, serum levels of gamma-GTP and ALP remained high and hepatosplenomegaly gradually increased. A liver biopsy was performed...
  18. ncbi Clinical significance of serum total and heat-stable alkaline phosphatase in leukemia patients
    P S Patel
    Division of Research, Gujarat Cancer Society, New Civil Hospital Compound, Ahmedabad, India
    Tumori 79:352-6. 1993
    AIMS AND BACKGROUND: Variations in serum alkaline phosphatase (ALP) and placental-like (heat stable) alkaline phosphatase (PLAP) are found to be clinically useful in cancer patients...
  19. ncbi Alkaline phosphatase activity in gingival crevicular fluid during human orthodontic tooth movement
    Giuseppe Perinetti
    Department of Orthodontics, University G D Annunzio, Chieti, Italy
    Am J Orthod Dentofacial Orthop 122:548-56. 2002
    ..We used a longitudinal design to investigate alkaline phosphatase (ALP) activity in gingival crevicular fluid (GCF) to assess whether it can serve as a diagnostic aid in orthodontics...
  20. ncbi A prospective study of bone loss and turnover after cardiac transplantation: effect of calcium supplementation with or without calcitonin
    M J Valimaki
    Department of Medicine, University of Helsinki, Finland
    Osteoporos Int 10:128-36. 1999
    ..Markers of bone formation [serum bone-specific alkaline phosphatase (B-ALP), type I procollagen carboxyterminal propeptide (PICP) and aminoterminal propeptide (PINP)] and resorption [serum ..
  21. ncbi Biochemical parameters as prognostic factors in prostatic adenocarcinoma
    S Vesalainen
    Department of Surgery, University of Kuopio, Finland
    Acta Oncol 34:53-9. 1995
    The serum levels of creatinine (CR), alkaline phosphatase (ALP), acid phosphatase (ACP) and tartrate inhibitable acid phosphatase (TIAP) were related to Gleason score, TM-category, disease progression and survival in 325 prostatic ..
  22. doi Sclerostin and the regulation of bone formation: Effects in hip osteoarthritis and femoral neck fracture
    Jon Power
    Bone Research Division, Department of Medicine, University of Cambridge, Cambridge, UK
    J Bone Miner Res 25:1867-76. 2010
    ..5 mm in diameter) with at least one canal staining for alkaline phosphatase (ALP), a marker of bone formation...
  23. doi Hyperglycemia in acute aluminum phosphide poisoning as a potential prognostic factor
    O Mehrpour
    Department of Forensic Medicine, Faculty of Medicine, Medical Sciences University of Tehran, Tehran, Iran
    Hum Exp Toxicol 27:591-5. 2008
    Aluminum phosphide (AlP) is a solid fumigant widely used in Iran as a grain preservative...
  24. ncbi [Effect of preoperative biliary drainage on liver function changes in patients with malignant obstructive jaundice in the low bile duct before and after pancreaticoduodenectomy]
    Dong Chen
    Department of Hepatobiliary Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guangdong, PR China
    Ai Zheng 27:78-82. 2008
    ..This study was to investigate the perioperative liver function changes and prognosis of the patients...
  25. ncbi Effects of retinoic acid on N-glycosylation and mRNA stability of the liver/bone/kidney alkaline phosphatase in neuronal cells
    W H Mueller
    Zentrum Biochemie, Medizinische Hochschule Hannover, Hannover, Germany
    J Cell Physiol 182:50-61. 2000
    Alkaline phosphatase (ALP) is a glycoenzyme that is highly expressed during carcinogenesis and is induced by retinoic acid (RA) in various cells...
  26. pmc Role of alkaline phosphatase from Manduca sexta in the mechanism of action of Bacillus thuringiensis Cry1Ab toxin
    Ivan Arenas
    Departamento de Microbiologia Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos 62250, Mexico
    J Biol Chem 285:12497-503. 2010
    ..Two Manduca sexta glycosylphosphatidylinositol-anchored proteins, aminopeptidase (APN) and alkaline phosphatase (ALP), have been shown to bind Cry1Ab, although their role in toxicity remains to be determined...
  27. ncbi Nuclear plasticity and timing mechanisms of the initiation of alkaline phosphatase expression in cytoplasm-transferred blastomeres of ascidians
    K Kobayashi
    Department of Biological Sciences, Tokyo Institute of Technology, Nagatsuta, Midori ku, Yokohama, 226 8501, Japan
    Dev Biol 234:510-20. 2001
    ..We investigated three aspects of the expression of endoderm-specific alkaline phosphatase (ALP) activity...
  28. ncbi Mapping quantitative trait loci that influence blood levels of alkaline phosphatase in MRL/MpJ and SJL/J mice
    A K Srivastava
    Musculoskeletal Disease Center, JLP VA Medical Center, Loma Linda, CA, 92357, USA
    Bone 35:1086-94. 2004
    To examine the hypothesis that serum alkaline phosphatase (ALP) levels have a heritable component, we analyzed blood from two inbred strains of mice, MRL/MpJ and SJL, which exhibit 90% difference in total serum ALP activity (268+/-26 vs...
  29. ncbi Effect of glucocorticoid treatment on biochemical and hormonal blood parameters in early pregnant gilts
    A Madej
    Department of Animal Physiology, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Acta Vet Scand 38:263-73. 1997
    ..for analysis of aspartate aminotransferase (S-ASAT), alanine aminotransferase (S-ALAT), alkaline phosphatase (S-ALP), S-cholesterol, S-triglycerides, S-fructosamine, S-urea, S-total protein, and for electrophoretic fractionation of ..
  30. ncbi Longitudinal monitoring of subgingival colonization by Actinobacillus actinomycetemcomitans, and crevicular alkaline phosphatase and aspartate aminotransferase activities around orthodontically treated teeth
    Giuseppe Perinetti
    Unit of Orthodontics, Department of Oral Sciences, School of Dentistry, University G D Annunzio, Chieti, Italy
    J Clin Periodontol 31:60-7. 2004
    ..design to examine subgingival colonization of Actinobacillus actinomycetemcomitans (Aa) and alkaline phosphatase (ALP) and aspartate aminotransferase (AST) activities in gingival crevicular fluid (GCF) in order to assess whether ..
  31. ncbi Temporal pattern of stimulation of osteoblast-associated genes during mechanically-induced osteogenesis in vivo: early responses of osteocalcin and type I collagen
    D Pavlin
    Department of Orthodontics, The University of Texas Health Science Center at San Antonio, 78284 7910, USA
    Connect Tissue Res 42:135-48. 2001
    ..Temporal pattern of regulation of osteocalcin (OC), alkaline phosphatase (ALP), and type I collagen (collagen I) was determined during mechanically-induced osteoblast differentiation in vivo, ..
  32. ncbi Risk factors affecting metaphyseal irregularities in the radius and ulna of growing Newfoundland dogs
    C Trangerud
    Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, PO Box 8146 Dep, N 0033 Oslo, Norway
    J Anim Sci 85:2437-44. 2007
    ..effects of litters, BW, circumferences of the distal radius and ulna (CDRU), and total serum alkaline phosphatase (ALP) concentrations. The study included 118 Newfoundland dogs (60 females, 58 males), derived from 32 litters...
  33. ncbi Comparison of two newly identified tumor markers (CAR-3 and DU-PAN-2) with CA 19-9 in patients with pancreatic cancer
    C Ferrara
    Istituto di Medicina Interna,
    Tumori 77:56-60. 1991
    ..Correlations were found between the behavior of all three markers and that of the cholestasis indices (ALP and GGT)...
  34. ncbi Osteoporotic cytokines and bone metabolism on rats with induced hyperthyroidism; changes as a result of reversal to euthyroidism
    Gonul Simsek
    Istanbul University, Turkey
    Chin J Physiol 46:181-6. 2003
    ..and serum IL-1beta, IL-6, TNFalpha, Calcium (Ca), phosphorous (P), parathyroid hormone (PTH), alkaline phosphatase (ALP), bone alkaline phosphatase (B-ALP) levels were measured and differential leucocyte counts were made initially, at ..
  35. ncbi Monoclonal antibodies against tissue-nonspecific alkaline phosphatase. Report of the ISOBM TD9 workshop
    P Magnusson
    Bone and Mineral Metabolic Unit, Division of Clinical Chemistry, Department of Biomedicine and Surgery, Linkoping University Hospital, Linkoping, Sweden
    Tumour Biol 23:228-48. 2002
    ..The evaluation included the following antigen forms: (a) commercially available preparations of human bone ALP (BALP) and liver ALP (LALP); (b) human BALP isoforms, B/I, B1 and B2; and (c) soluble secreted epitope-tagged ..
  36. pmc Hepatic osteodystrophy and liver cirrhosis
    Vedat Goral
    Department of Gastroenterology, Dicle University School of Medicine, 21280 Diyarbakir, Turkey
    World J Gastroenterol 16:1639-43. 2010
    ..To investigate the correlation between hepatic osteodystrophy and osteoporosis in patients with liver cirrhosis...
  37. ncbi Changes in the structure and function of the kidney of rats chronically exposed to cadmium. I. Biochemical and histopathological studies
    Małgorzata M Brzóska
    Department of Toxicology, Medical University of Białystok, Mickiewicza 2c str, 15 222, Białystok, Poland
    Arch Toxicol 77:344-52. 2003
    ..as urinary total N-acetyl-beta- d-glucosaminidase (NAG-T) and its isoenzyme B (NAG-B), and alkaline phosphatase (ALP) were used...
  38. ncbi Genotype-by-sex and environment-by-sex interactions influence variation in serum levels of bone-specific alkaline phosphatase in adult baboons (Papio hamadryas)
    L M Havill
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Bone 35:198-203. 2004
    ..we conducted a statistical genetic analysis of serum concentrations of bone-specific alkaline phosphatase (Bone ALP), a highly specific marker of osteoblast function that is elevated in persons with conditions like osteoporosis ..
  39. ncbi Role of ascorbic acid in periodontal ligament cell differentiation
    Satoshi Ishikawa
    Section of Periodontology, Dept of Hard Tissue Engineering, Graduate School, Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University, Japan
    J Periodontol 75:709-16. 2004
    ..The purpose of this study was to determine the role of ascorbic acid on the early osteoblastic differentiation of PDL cells, with regard to alkaline phosphatase (ALP) activity, type I collagen production and integrin expression.
  40. doi Risk factors for abnormal liver function tests in patients with ileal pouch-anal anastomosis for underlying inflammatory bowel disease
    Udayakumar Navaneethan
    The Pouchitis Clinic, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 104:2467-75. 2009
    ..The aim of this study was to evaluate the prevalence and to identify risk factors for abnormal LFTs in patients with IPAA and underlying IBD...
  41. pmc Circulating insulin-like growth factor binding protein-4 (IGFBP-4) is not regulated by parathyroid hormone and vitamin D in vivo: evidence from children with rickets
    Abdullah Bereket
    Marmara University Medical Faculty, Department of Pediatric Endocrinology, Istanbul, Turkey
    J Clin Res Pediatr Endocrinol 2:17-20. 2010
    ..25-hydroxy(OH)vitamin D, IGF-I, IGF-II and transforming growth factor (TGF)-b are the major regulators of IGFBP-4 production in vitro. However, little is known about the in vivo regulation of circulating IGFBP-4 in humans...
  42. ncbi Adult hypophosphatasia treated with teriparatide
    Michael P Whyte
    Center for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children, and Division of Bone and Mineral Diseases, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MI 63131 3597, USA
    J Clin Endocrinol Metab 92:1203-8. 2007
    Hypophosphatasia (HPP) features low serum alkaline phosphatase (ALP) activity (hypophosphatasemia) due to loss-of-function mutation within TNSALP, the gene that encodes "tissue-nonspecific" ALP (TNSALP)...
  43. ncbi Alterations of blood analyses at relapse of osteosarcoma and Ewing's sarcoma
    E Hannisdal
    Department of Oncology, Norwegian Radium Hospital, Oslo
    Acta Oncol 29:585-7. 1990
    ..and thrombocyte counts, gamma glutamyltransferase (GT), lactate dehydrogenase (LD) and alkaline phosphatase (ALP). Sixteen relapsing patients diagnosed from 1970 to 1987 were eligible in each sarcoma group...
  44. ncbi [Comparison of whole bone marrow culture method and density gradient centrifugation method of isolating hBMSCs]
    Qian Huang
    Lnstitute of Plastic and Aesthetic Surgery, Guangdong Medical College, Zhanjiang Guangdong 524023, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23:1360-4. 2009
    ..To make a comparative study on the effects of whole bone marrow culture method and density gradient centrifugation method in isolating hBMSCs...
  45. ncbi The effect of olpadronate in ovariectomized thyroxine-treated rats
    S Zeni
    Seccion Osteopatias Medicas, Hospital de Clinicas, Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Bone 21:329-33. 1997
    ..of the study, blood samples were analyzed for serum calcium, phosphorus, T4, total and bone alkaline phosphatase (ALP and b-ALP), and urinary samples for hydroxyproline/creatinine ratio (HOProl/creat)...
  46. ncbi The effect of different buffers and amounts of intestinal alkaline phosphatase isoforms on total alkaline phosphatase activity
    Makoto Matsushita
    Department of Clinical Chemistry, Saitama Prefectural University Junior College, 820 Sannomiya, Koshigaya 343 8540, Japan
    Clin Chim Acta 319:49-55. 2002
    ..DEA and 2-ethylaminoethanol, EAE) have been widely used for the measurement of serum total alkaline phosphatase activity (ALP) in clinical laboratories, and the individual isozyme are activated differently by respective buffers.
  47. ncbi Molecular characterization of a PDZ-LIM protein in Atlantic salmon (Salmo salar): a fish ortholog of the alpha-actinin-associated LIM-protein (ALP)
    Øivind Andersen
    Institute of Aquaculture Research, P O Box 5010, N 1432 Aas, Norway
    J Muscle Res Cell Motil 25:61-8. 2004
    ..A full-length cDNA encoding the ortholog of the alpha-actinin-associated LIM protein (ALP) was isolated from white skeletal muscle of Atlantic salmon (Salmo salar)...
  48. ncbi [Interventional effect of platelet lysate on osteogenic differentiation of BMSCs in rats]
    Huiping Song
    Shanxi Provincial Tissue Bank, Taiyuan Shanxi, 030006, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 22:737-41. 2008
    ..To explore the interventional effect of platelet lysate (PL) on osteogenic differentiation of BMSCs by induction in rats in vitro...
  49. doi Early predisposition to osteomalacia in Indian adults on phenytoin or valproate monotherapy and effective prophylaxis by simultaneous supplementation with calcium and 25-hydroxy vitamin D at recommended daily allowance dosage: a prospective study
    Geetha Krishnamoorthy
    Department of Biochemistry, Lokmanya Tilak Municipal Medical College and Hospital, Sion, Mumbai 400 022, India
    Neurol India 58:213-9. 2010
    Long-term therapy with antiepileptic drugs (AED) may be associated with increased total serum alkaline phosphatase (ALP) levels and reduced serum calcium, inorganic phosphorous, and vitamin D levels...
  50. ncbi Isoenzyme studies on Toxoplasma gondii isolates using isoelectric focusing
    G Barnert
    ,
    Zentralbl Bakteriol Mikrobiol Hyg A 268:476-81. 1988
    ..of the following 14 enzymes in the cell lysates was investigated: IDH, MDH, ME, 6PG, G6P, LDH, IPO, HEX, PGM, EST, ALP, ACP, LAP, and PGI...
  51. ncbi Expression of the germ cell alkaline phosphatase gene in human choriocarcinoma cells
    S Watanabe
    Human Genetics Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892
    J Biol Chem 264:12611-9. 1989
    Alkaline phosphatase (ALP) in human choriocarcinoma cells (malignant trophoblasts) was characterized by its greater sensitivity to EDTA and L-leucine inhibition as compared with the placental isozyme...
  52. ncbi Immunochemical characterization of alkaline phosphatase from the fluid of sterile and fertile Echinococcus granulosus cysts
    Ali Vatankhah
    Parasitology Department, Pasteur Institute of Iran, Pasteur Square, 13164, Tehran, Iran
    Parasitol Res 90:372-6. 2003
    Alkaline phosphatase (ALP) from hydatid cyst fluid (HCF) was purified and characterized for comparison between fertile and sterile HCF. Samples were obtained from slaughtered sheep and then sterile and fertile cysts were separated...
  53. ncbi Comparative inhibition of human alkaline phosphatase and diamine oxidase by bromo-levamisole, cimetidine and various derivatives
    T Metaye
    Department of Biochemistry, U E R of Medecine Pharmacy, Poitiers, France
    Biochem Pharmacol 37:4263-8. 1988
    ..are examined in vitro in order to investigate their comparative inhibition, towards alkaline phosphatase (ALP) from human liver and diamine-oxidase (DAO) from human placenta...
  54. ncbi Bone marrow adipocytes: a neglected target tissue for growth hormone
    Evelien F Gevers
    Division of Molecular Neuroendocrinology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Endocrinology 143:4065-73. 2002
    ..005) lower in dw/dw rats, though alkaline phosphatase (ALP) activity in individual osteoblasts was unchanged...
  55. ncbi Porous tantalum trabecular metal scaffolds in combination with a novel marrow processing technique to replace autograft
    Xuenong Zou
    Orthopaedic Research Laboratory, Aarhus University Hospital, 8000 Aarhus C, Denmark
    Adv Exp Med Biol 585:197-208. 2006
    ....
  56. ncbi Automated and semiautomated analysis of rat alkaline phosphatase isoenzymes
    W E Hoffmann
    University of Illinois College of Veterinary Medicine, College of Veterinary Medicine, Urbana 61801, USA
    Toxicol Pathol 22:633-8. 1994
    A semiautomated quantitative assay for rat serum alkaline phosphatase (ALP) isoenzyme determination was developed, incorporating selective precipitation of bone alkaline phosphatase (BALP) with wheat germ lectin and differential ..
  57. ncbi Prenatal exposure to diazepam and alprazolam, but not to zolpidem, affects behavioural stress reactivity in handling-naïve and handling-habituated adult male rat progeny
    Carla Cannizzaro
    Department of Pharmacological Sciences, Palermo University, V Vespro 129, 90127 Palermo, Italy
    Brain Res 953:170-80. 2002
    ..study investigated the consequences of a late prenatal treatment with three GABA/BDZ R agonists (DZ) alprazolam (ALP) and zolpidem (ZOLP)), on different stress-related behavioural patterns, in non-handled (NH), short-lasting handled ..
  58. ncbi Influence of lighting conditions on daily rhythm of bone metabolism in rats and possible involvement of melatonin and other hormones in this process
    Z Ostrowska
    Department of Clinical Biochemistry, The Medical University of Silesia, Zabrze, Poland
    Endocr Regul 37:163-74. 2003
    ..of biochemical markers of bone and mineral metabolism such as the activity of serum alkaline phosphatase (ALP), the concentration of carboxyterminal propeptide of type I procollagen (PICP), cross-linked carboxyterminal ..
  59. ncbi [Experimental study of the effect of new bone formation on new type artificial bone composed of bioactive ceramics]
    Minghua Zhu
    Sichuan Diseases Control and Prevention, Chengdu Sichuan 610041, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 19:174-7. 2005
    ..To investigate the osteogenic potential of four kinds of new bioactive ceramics combined with bovine bone morphogenetic proteins (BMP) and to explore the feasibility of using compounds as bone substitute material...
  60. ncbi Preoperative localization of parathyroid adenomas with technetium-99m methoxyisobutylisonitrile imaging: relationship with P-glycoprotein expression, oxyphilic cell content, and tumoral tissue volume
    Bulent Turgut
    Department of Nuclear Medicine, Cumhuriyet University School of Medicine, Sivas, Turkey
    Cancer Biother Radiopharm 21:579-90. 2006
    ....
  61. ncbi Novel mouse model of autosomal semidominant adult hypophosphatasia has a splice site mutation in the tissue nonspecific alkaline phosphatase gene Akp2
    Tertius A Hough
    Mammalian Genetics Unit, Mary Lyon Centre, Medical Research Council, Harwell, Oxfordshire, United Kingdom
    J Bone Miner Res 22:1397-407. 2007
    ..Here we report on mice with an induced mutation in Akp2 that affects splicing. The phenotype of homozygotes mirror aspects of the adult form of HPP...
  62. ncbi Novel loci regulating bone anabolic response to loading: expression QTL analysis in C57BL/6JXC3H/HeJ mice cross
    Chandrasekhar Kesavan
    Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, 11201 Benton Street, Loma Linda, CA 92357, USA
    Bone 41:223-30. 2007
    ..We then measured the expression changes of bone marker genes, bone sialoprotein (BSP), alkaline phosphatase (ALP) and housekeeping genes, beta-actin and peptidylprolyl isomerase A (PPIA), by using real-time PCR in both the ..
  63. ncbi Gingival crevicular fluid alkaline phosphatase activity reflects periodontal healing/recurrent inflammation phases in chronic periodontitis patients
    Giuseppe Perinetti
    Department of Oral Sciences, University G D Annunzio, Chieti, Italy
    J Periodontol 79:1200-7. 2008
    ..One of these host enzymes is alkaline phosphatase (ALP), the GCF activity of which has been associated with periodontal inflammation...
  64. ncbi [Effect of various concentrations of platelet-rich plasma on osteogenic differentiation of skeletal muscle-derived stem cells]
    Liancheng Shan
    Department of Orthopaedics, Shanghai Sixth People s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23:991-6. 2009
    ..To investigate the effect of various concentration of platelet-rich plasma (PRP) on osteogenic differentiation of rabbit skeletal muscle-derived stem cells (SMSCs) cultured in vitro...
  65. ncbi Effects of cortical bone perforation on experimental guided bone regeneration
    Ichiro Nishimura
    Division of Oral Pathology, Graduate School of Dentistry, Tohuku University, Sendai, Japan
    Clin Oral Implants Res 15:293-300. 2004
    ..Alkaline phosphatase (ALP) was expressed on the bone surrounding the perforation...
  66. ncbi Functional analysis of the single nucleotide polymorphism (787T>C) in the tissue-nonspecific alkaline phosphatase gene associated with BMD
    Masae Goseki-Sone
    Department of Food and Nutrition, Japan Women s University, Tokyo, Japan
    J Bone Miner Res 20:773-82. 2005
    ..Furthermore, the effects of amino acid substitution on the catalytic property of the protein translated from the 787T>C gene were examined...
  67. doi Effect of smoking and CYP2D6 polymorphisms on the extent of fluvoxamine-alprazolam interaction in patients with psychosomatic disease
    Hideyo Sugahara
    Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Clin Pharmacol 65:699-704. 2009
    ..The aim of this study was to investigate the factors responsible for interindividual variability in the extent of interaction between FVX and alprazolam (ALP).
  68. doi Up-regulation of alkaline phosphatase expression in human primary osteoblasts by cocultivation with primary endothelial cells is mediated by p38 mitogen-activated protein kinase-dependent mRNA stabilization
    Sven Hager
    Department of Plastic and Hand Surgery, University of Freiburg Medical Center, Freiburg, Germany
    Tissue Eng Part A 15:3437-47. 2009
    ..ECs and human primary osteoblasts (hOBs) leads to a cell contact-dependent up-regulation of alkaline phosphatase (ALP) expression in osteoblasts, indicating that cocultivated ECs may support osteogenic differentiation and ..
  69. ncbi Amino acid phosphatase activity of alkaline phosphatase. A possible role of protein phosphatase
    T Shinozaki
    Department of Orthopedic Surgery, Gunma University School of Medicine, Maebashi, Japan
    Eur J Biochem 227:367-71. 1995
    Alkaline phosphatase (ALP) hydrolyzed phosvitin and amino acid phosphates demonstrating nonisotropy at different pH...
  70. ncbi Calciuria in children with juvenile chronic arthritis
    D Nemcova
    Department of Pediatrics, First Medical Faculty, Charles University, Prague, Czech Republic
    Acta Univ Carol Med (Praha) 40:43-5. 1994
    ..12 patients with confirmed diagnosis of JCA basic biochemical indices of bone metabolism, were performed (S-Ca, P, ALP, U-Ca/U-creatinine, U-P)...
  71. ncbi Characterization of titanium surfaces with calcium and phosphate and osteoblast adhesion
    B Feng
    School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, PR China
    Biomaterials 25:3421-8. 2004
    ..The cell count and alkaline phosphatase (ALP) specific activity assay were used for biochemical analyses...
  72. doi Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis
    Christophe Corpechot
    Hepatology Department, Reference Center for Inflammatory Biliary Diseases, Saint Antoine Hospital, National Institute of Health and Medical Research INSERM, Pierre et Marie Curie University Paris 6, France
    Hepatology 48:871-7. 2008
    ..It has been recently proposed that an alkaline phosphatase (ALP) decline of more than 40% in baseline value or a normal level after 1 year of UDCA treatment (Barcelona criteria) ..
  73. doi Changes in alkaline phosphatase levels in patients with prostate cancer receiving degarelix or leuprolide: results from a 12-month, comparative, phase III study
    Fritz H Schroder
    Department of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands
    BJU Int 106:182-7. 2010
    ..5 mg in the control of total serum alkaline phosphatase (S-ALP) levels in patients with prostate cancer...
  74. ncbi Bone and mineral metabolism in transient hyperphosphatasaemia
    S Kutilek
    Department of Pediatrics, 1st Medical Faculty, Charles University, Prague, Czech Republic
    Acta Univ Carol Med (Praha) 40:47-51. 1994
    Transient hyperphosphatasaemia (TH) is a benign disorder characterized by transient elevation of S-ALP activity not exceeding duration of 4 months in children under 5 years of age, with elevated activity of bone isoenzymes of ALP with no ..
  75. ncbi Glycitein effect on suppressing the proliferation and stimulating the differentiation of osteoblastic MC3T3-E1 cells
    H Yoshida
    Graduate School of Human and Environmental Studies, Kyoto University, Japan
    Biosci Biotechnol Biochem 65:1211-3. 2001
    ..about 5%) suppressed the proliferation of MC3T3-E1 and stimulated bone-related protein (alkaline phosphatase (ALP) and osteocalcin (OC)) expression...
  76. ncbi A potent 1,4-dihydropyridine L-type calcium channel blocker, benidipine, promotes osteoblast differentiation
    Y Nishiya
    Tokyo Research Laboratories, Kyowa Hakko Kogyo Co, Ltd, 3 6 6 Asahi machi, Machida, Tokyo 194 8533, Japan
    Calcif Tissue Int 70:30-9. 2002
    During their differentiation, osteoblasts sequentially express type I collagen, alkaline phosphatase (ALP), and osteocalcin, and then undergo mineral deposition...
  77. ncbi Plasma biochemical values from apparently healthy free-ranging polar bears from Svalbard
    Morten Tryland
    Department of Arctic Veterinary Medicine, Norwegian School of Veterinary Science, NO 9292 Tromsø, Norway
    J Wildl Dis 38:566-75. 2002
    ..Several parameters varied with age. Levels of alkaline phosphatase (ALP) and calcium (Ca) decreased with age, being significantly higher in young individuals (< 6 yr) compared to ..
  78. ncbi Activation of osteo-progenitor cells by a novel synthetic peptide derived from the bone morphogenetic protein-2 knuckle epitope
    Atsuhiro Saito
    Graduate School of Materials Science, Nara Institute of Science and Technology, 8916 5 Takayama, Nara 630 0192 Ikoma, Japan
    Biochim Biophys Acta 1651:60-7. 2003
    ..corresponding to residues 73-92 of the knuckle epitope of BMP-2, elevated alkaline phosphatase (ALP) activity in the murine multipotent mesenchymal cell line, C3H10T1/2...
  79. pmc Golgi-to-late endosome trafficking of the yeast pheromone processing enzyme Ste13p is regulated by a phosphorylation site in its cytosolic domain
    Holly D Johnston
    Division of Biological Sciences, University of Missouri, Columbia, MO 65211
    Mol Biol Cell 16:1456-68. 2005
    ..The TGN membrane proteins A-ALP, a model protein containing the Ste13p cytosolic domain fused to alkaline phosphatase (ALP), and Kex2p were found ..
  80. ncbi Responses of MC3T3-E1 cells to three dental resin-based restorative materials
    Satoshi Imazato
    Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biomed Mater Res A 76:765-72. 2006
    ..were observed by scanning electron microscopy, and mitochondrial dehydrogenase and alkaline phosphatase (ALP) activities of the cells were evaluated. Cell cultures on polystyrene tissue culture dishes served as controls...
  81. ncbi Downregulation of cAMP-dependent protein kinase inhibitor gamma is required for BMP-2-induced osteoblastic differentiation
    L Zhao
    Nankai University Medical College, Tianjin 300071, China
    Int J Biochem Cell Biol 38:2064-73. 2006
    ..This correlated with decreased alkaline phosphatase (ALP) activities...
  82. doi Lactate dehydrogenase activity is increased in plasma of infants with advanced necrotizing enterocolitis
    Francesco Morini
    Neonatal Surgery Unit, Bambino Gesu Children s Hospital, Piazza S Onofrio, 4, 00165, Rome, Italy
    Pediatr Surg Int 24:705-9. 2008
    ..Serum activities of alkaline phosphatase (ALP), glutamic oxaloacetic transaminase (GOT), creatine kinase (CK), and lactate dehydrogenase (LDH) were compared in ..
  83. doi Infusion of ibandronate once every 3 months effectively decreases bone resorption markers and increases bone mineral density in Chinese postmenopausal osteoporotic women: a 1-year study
    Mei Li
    Department of Endocrinology, Endocrine Key Laboratory of the Health Ministry of China, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
    J Bone Miner Metab 28:299-305. 2010
    ..Significant decreases in serum c-telopeptide of type I collagen (CTX) and alkaline phosphatase (ALP) were found in the two groups after 1 and 3 months of treatment, respectively; these serum CTX and ALP levels were ..
  84. doi Midgut GPI-anchored proteins with alkaline phosphatase activity from the cotton boll weevil (Anthonomus grandis) are putative receptors for the Cry1B protein of Bacillus thuringiensis
    Erica Soares Martins
    Universidade de Brasilia, Departamento de Biologia Celular, Brasilia, DF, Brazil
    Insect Biochem Mol Biol 40:138-45. 2010
    ..was analyzed and we found that Cry1Ba6 binds to two proteins (62 and 65kDa) that showed alkaline phosphatase (ALP) activity...
  85. doi Mitochondrial energy metabolism impairment and liver dysfunction following chronic exposure to dichlorvos
    B K Binukumar
    Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India
    Toxicology 270:77-84. 2010
    ..enzyme activities and increase ROS levels in turn might have caused an increase in liver enzymes (ALT, AST and ALP)...
  86. ncbi Contribution of bone morphogenetic protein-2 to aortic valve calcification in aged rat
    Kazuhiko Seya
    Department of Pharmacology, Hirosaki University Graduate School of Medicine, Japan
    J Pharmacol Sci 115:8-14. 2011
    ..Spontaneous calcification, the expressions of calcigenic genes, that is, BMP-2, alkaline phosphatase (ALP), and osterix (osteogenic transcription factor) and ALP enzyme activity in AVICs from aged rats were enhanced in ..
  87. doi Icariin is more potent than genistein in promoting osteoblast differentiation and mineralization in vitro
    Hui Ping Ma
    Department of Pharmacy, Lanzhou General Hospital, Lanzhou Command of CPLA, Lanzhou 730050, People s Republic of China
    J Cell Biochem 112:916-23. 2011
    ..Dose-dependent studies in osteoblast differentiation measuring alkaline phosphatase (ALP) activity revealed optimal concentrations of genistein and icarrin for stimulating osteogenesis to be both at 10(-5)..
  88. doi Hepatotoxicity and nephrotoxicity produced by 4-hydroxy-2-nonenal (4-HNE) following 4-week oral administration to Sprague-Dawley rats
    Se Chan Kang
    Department of Natural Product Resources, Semyung University, Jecheon, South Korea
    J Toxicol Environ Health A 74:779-89. 2011
    ..biomarkers, such as levels of blood urea nitrogen (BUN) and creatinine and activity of alkaline phosphatase (ALP), and urinary creatinine and protein levels at 0.5 mg/kg/d...
  89. ncbi Cytotoxic potency and induced biochemical parameters in mice serum of new furan derivatives against liver cancer cell line
    Hala F Abdel-Hamid
    Chemistry of Pesticides Dept, National Research Center, Dokki, Giza, Egypt
    Acta Pol Pharm 68:499-505. 2011
    ..derivatives on some enzymes such as aspartate and a lanine aminotransferases (ASTand ALT) and alkaline phosphatase (ALP), in addition to albumin, globulins, creatinine, total lipids, cholesterol, triglycerides and bilirubin in serum of ..
  90. ncbi Thymoquinone ameliorates the immunological and histological changes induced by exposure to imidacloprid insecticide
    Mohamed Mohany
    Zoology Department, College of Science, King Saud University, 11451 Riyadh, Saudi Arabia
    J Toxicol Sci 37:1-11. 2012
    ..of antibodies, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and malondialdehyde (MDA) compared to the control group. In contrast, significant decreases (P < 0...
  91. doi Ameliorative effect of silibinin against N-nitrosodimethylamine-induced hepatic fibrosis in rats
    Devaraj Ezhilarasan
    Food and Hepatotoxicology Laboratory, Department of Pharmacology and Environmental Toxicology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Sekkizhar Campus, Taramani, Chennai 600 113, India
    Environ Toxicol Pharmacol 34:1004-13. 2012
    ..Oral administration of SBN recovered body and liver weight loss and reversed the elevation of serum AST, ALT and ALP accompanied by their fall in the liver tissue in DMN-induced fibrotic rats...
  92. doi Exogenously added BMP-6, BMP-7 and VEGF may not enhance the osteogenic differentiation of human adipose stem cells
    Laura Kyllönen
    Adult Stem Cells, Institute of Biomedical Technology, Biokatu, University of Tampereo, Finland
    Growth Factors 31:141-53. 2013
    ..In 3D-culture OM promoted significantly total collagen production, whereas in 2D-culture OM induced high total ALP activity and mineralization compared to control and growth factors groups, but also high cell proliferation...
  93. doi A comparison of polymer and polymer-hydroxyapatite composite tissue engineered scaffolds for use in bone regeneration. An in vitro and in vivo study
    E Tayton
    Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, University of Southampton Medical School, Southampton, SO16 6YD, United Kingdom
    J Biomed Mater Res A 102:2613-24. 2014
    ..SSC survival was demonstrated on all polymers, but the PLA polymers showed enhanced osteoblastic activity (ALP assay p < 0.01) and collagen-1 formation. In vivo analysis was performed on PLA and PLA+10% HA...
  94. doi Effects of the combination of dexamethasone and fibroblast growth factor‑2 on differentiation of osteoprecursor cells
    Jun Beom Park
    Department of Periodontics, Seoul St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul 137 701, Republic of Korea
    Mol Med Rep 9:659-62. 2014
    ..The alkaline phosphatase (ALP) activity test was performed to assess differentiation and protein expression associated with bone formation was ..
  95. doi Osteogenesis induction of periodontal ligament cells onto bone morphogenic protein-2 immobilized PCL fibers
    Sung Eun Kim
    Department of Orthopedic Surgery and Rare Diseases Institute, Korea University Medical Center, Guro Hospital, 148, Gurodong ro, Guro Gu, Seoul 152 703, Republic of Korea
    Carbohydr Polym 99:700-9. 2014
    ..Osteogenic differentiation of PDLCs was demonstrated by alkaline phosphatase (ALP) activity, calcium deposition, and gene expression...
  96. doi FFAs-ROS-ERK/P38 pathway plays a key role in adipocyte lipotoxicity on osteoblasts in co-culture
    Xin Dong
    Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, 15 Changle West Road, Xi an, Shaanxi 710032, People s Republic of China
    Biochimie 101:123-31. 2014
    ..proliferation and function and induced osteoblasts apoptosis, evidenced by decreased cell viability/proliferation, ALP activity, expression of runt-related transcription factor 2 (RunX2), type I collagen (ColA1) and osteocalcin and ..
  97. doi Insight on the interaction of an agmatinase-like protein with Mn(2+) activator ions
    Matías Quiñones
    Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Biologicas, Universidad de Concepcion, Casilla 160 C, Concepcion, Chile
    J Inorg Biochem 145:65-9. 2015
    ..An agmatinase-like protein (ALP) from rat brain was identified that bears no sequence homology to known agmatinases (E. Uribe, M. Salas, S...
  98. doi Cardioprotective effect of linseed oil against isoproterenol-induced myocardial infarction in Wistar rats: a biochemical and electrocardiographic study
    Amal Derbali
    Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, University of Sfax, P O Box 95, 3052, Sfax, Tunisia
    J Physiol Biochem 71:281-8. 2015
    ..T and cardiac injury markers (creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), aspartate transaminase (AST), and alanine transaminase (ALT))...
  99. doi Gelatinases promote calcification of vascular smooth muscle cells by up-regulating bone morphogenetic protein-2
    Yong gang Zhao
    Institute of Microcirculation and Key Laboratory, Ministry of Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Electronic address
    Biochem Biophys Res Commun 470:287-93. 2016
    ..Phenotype transition of VSMCs was observed by assessing expressions of alkaline phosphatase (ALP), smooth muscle α-actin (SM-α-actin) and desmin...
  100. doi The effect of different implant biomaterials on the behavior of canine bone marrow stromal cells during their differentiation into osteoblasts
    F Ozdal-Kurt
    a Department of Biology, Faculty of Life Science, Celal Bayar University, Manisa, Turkey
    Biotech Histochem 91:412-22. 2016
    ..using alizarin red (AR), immunocytochemistry and osteoblastic markers including alkaline phosphatase/von Kossa (ALP/VK), osteocalcin (OC) and osteonectin (ON), and ELISA...
  101. doi Abuse liability assessment of eslicarbazepine acetate in healthy male and female recreational sedative users: A Phase I randomized controlled trial
    Naama Levy-Cooperman
    Formerly INC Research, 720 King Street West, Toronto, ON M5V2T3, Canada Electronic address
    Epilepsy Behav 61:63-71. 2016
    ..This Phase I study evaluated the abuse liability of ESL compared with that of alprazolam (ALP) and placebo (PBO) in recreational CNS depressant users.

Research Grants68

  1. STEVEN R MUMM; Fiscal Year: 2014
    ..The patient had never been diagnosed with HPP, although her serum ALP was low (26 U/L, Nl 32 - 116 U/L)...
  2. Xianzhong Meng; Fiscal Year: 2015
    ..a major role in TLR4-induced osteogenic responses, characterized by expression of Runx2, alkaline phosphatase (ALP) and osteopontin...
  3. Purinergic receptors in inflammation
    Wolfgang G Junger; Fiscal Year: 2012
    ..are recruited to the leading edge where adenosine is generated by CD39/E- NTPDase1 and alkaline phosphatase (ALP)...
  4. MINERALIZATION STUDIES RELATED TO ORAL BIOLOGY
    HARRISON ANDERSON; Fiscal Year: 2005
    ..We and others have provided evidence that MV phosphatases, including alkaline phosphatase (ALP), and ATPase are involved in MV mineralization...
  5. MOLECULAR BASIS OF PRONEPHRIC DUCT CELL GUIDANCE
    MALCOLM STEINBERG; Fiscal Year: 1991
    ..The molecule is identified as the cell-surface enzyme alkaline phosphatase (ALP). A prime focus of this project is to understand the role of ALP in guiding migrating embryonic cells...
  6. GROWTH FACTORS AND SKELETAL AGING
    Theresa Chen; Fiscal Year: 2000
    ..the bone forming potential of the osteoblasts is in direct proportion to the number of alkaline phosphatase (ALP) positive CFU-F...
  7. Xiaobin Wang; Fiscal Year: 2014
    ..outcomes, including (1) hormone dysfunction: reduced estrogen excretion (REE), anovulation, abnormal luteal phase (ALP), and abnormal follicular phase (AFP);(2) menstrual disorders;(3) infertility;(4) EPL and SAB;and (5) adverse birth ..
  8. Francesca Tentori; Fiscal Year: 2015
    ..These resources will be complemented by those at VUMC, including close mentorship by Dr. T. Alp Ikizler, interactions with other patient-oriented researchers and clinicians, and a vibrant scientific environment...
  9. Kelly A Birdwell; Fiscal Year: 2015
    ..My CTSA mentor, Dr. T. Alp Ikizler, is an internationally recognized leader on the metabolic complications of kidney disease and expert in the ..
  10. Effects of resistant starch on lipid and glucose metabolism in insulin resistance
    RONALD M contact KRAUSS; Fiscal Year: 2010
    ..with CVD risk in insulin resistant individuals who express components of the atherogenic lipoprotein phenotype (ALP)...
  11. Cellular Mechanisms of Neuropathology in Parkinson's Disease
    John J Shacka; Fiscal Year: 2013
    ..The autophagy- lysosome pathway (ALP) is an important intracellular degradation and recycling pathway and a compromise in ALP function promotes the ..
  12. Jacqui Smith; Fiscal Year: 2015
    ..PSID), the American Time Use Survey's (ATUS) new well-being module, and the American Life Panel's (ALP) DRM...
  13. ORGANOPHOSPHATE PESTICIDES AND HUMAN REPRODUCTIVE HEALTH
    Xiping Xu; Fiscal Year: 2003
    ..3) alterations in hormone patterns including reduced estrogen excretion (REE), anovulation, abnormal luteal phase (ALP), and abnormal follicular phase (AFP) in women and abnormalities of LH, FSH, TSH, SHBG, inhibin-B and testosterone ..
  14. RICHARD DENNIS WADDELL; Fiscal Year: 2015
    ..training will focus on the research support needs identified at MUHAS via the MUHAS-UCSF Academic Learning Program (ALP), including grant application preparation and submission, pre- and post-award management, financial management, ..
  15. Sarjeet S Gill; Fiscal Year: 2016
    ..Our research showed Aedes receptor proteins include cadherin, alkaline phosphatases (ALP), and aminopeptidases (APNs)...
  16. ACTININ ASSOCIATED LIM PROTEIN & FSH MUSCULAR DYSTROPHY
    David Bredt; Fiscal Year: 2002
    ..Recent molecular cloning studies have identified actinin-associated LIM protein (ALP), which is a novel component of the muscle cytoskeleton...
  17. DDT, Endocrine Disruption and Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2003
    ..with (1) hormone dysfunction including reduced estrogen excretion (REE), anovulation, abnormal luteal phase (ALP), and abnormal follicular phase (AFP); (2) menstrual disorders; (3) reduced fecundability; and (4) adverse ..
  18. Mireille Jacobson; Fiscal Year: 2014
    ..on the actual and perceived financial risk associated with health spending from the RAND American Life Panel (ALP)...
  19. ARIE KAPTEYN; Fiscal Year: 2015
    ..To that end we will conduct several experiments in two population representative Internet panels: the American Life Panel (ALP) in the U.S. and the Longitudinal Internet Studies for the Social sciences (LISS) panel in The Netherlands.
  20. REGULATION OF ADENINE NUCLEOTIDE POOLS
    Vern Schramm; Fiscal Year: 1993
    ..Regulation of AMP deaminase is similar to AMP nucleosidase by allosteric activation with ALP and inhibition by Pi. No prokaryotes have been found to contain AMP nucleosidase...
  21. REGULATION OF CECROPIN AND ATTACIN GENE EXPRESSION
    Peter Dunn; Fiscal Year: 1991
    ..control to peptidoglycan regulation of fat body cecropin-like protein (CLP) and attacin-like protein (ALP) synthesis; (2) to isolate and characterize M...
  22. Antibody- and peptide-inhibitors of quorum sensing
    Kim Janda; Fiscal Year: 2004
    ..Our proposed work includes the following aims: (1) synthesis of quorum sensing peptides and analogs from all 4 AlP subgroups of S...
  23. ALKYLLYSOPHOSPHOLIPIDS AS ANTITUMOR AGENTS
    David Lawrence; Fiscal Year: 1990
    ..We are currently investigating the synthesis of a series of alkyllysophospholipid-photosensitizers (ALP-photosensitizers) where the ALP component will serve as a vehicle for the selective delivery of the sensitizer ..
  24. ANTINEOPLASTIC ALKYLGLYCEROLIPIDS
    CLAUDE PIANTADOSI; Fiscal Year: 1990
    ..The preliminary in vitro data that contributed to the funding of these grants was obtained on small amounts of ALP analogues that were synthesized utilizing funds from other sources...
  25. Neuroendocrine Regulation of GnRH Release
    Jon Levine; Fiscal Year: 2006
    ..The K+ATP channel closes upon binding AlP, leading to reduced cellular K+ permeability, membrane depolarization and thus, increased cell excitability; ..
  26. Biogenesis of the T. brucei Mitochondrial ATP Synthase
    Noreen Williams; Fiscal Year: 2006
    ..brucel mitochondrial AlP synthase? 3. What is the effect of decreasing the level of the mitochondrial ATP synthase in bloodstream forms? 4...
  27. Control of cell polarity in the C. elegans zygote
    Geraldine Seydoux; Fiscal Year: 2005
    ..Establishment of the anterior-posterior (AlP) body axis of C. elegans depends on polarization of the zygote shortly after fertilization...
  28. ATHEROSCLEROTIC LESION PHANTOM (ALP) FOR MRI/A
    Thomas Burke; Fiscal Year: 2001
    ..The long term goal of this project is to develop an Atherosclerotic Lesion Phantom (ALP) to assist the MRI community develop non invasive applications to identify patients at risk for clinically acute CV ..
  29. Structure and function of muscle
    Mary Beckerle; Fiscal Year: 2005
    ..We have identified members of two families of LIM domain proteins, the Cysteine-Rich Protein (CRP) family and the ALP-Enigma family as a-actinin binding partners...
  30. CRANIOFACIAL SKELETON-OSTEOBLASTIC GENE EXPRESSION
    Joseph Zernik; Fiscal Year: 1993
    Alkaline phosphatase (ALP) is the earliest known marker of osteoblastic differentiation. The proposed studies use ALP expression to investigate mesenchymal-osteoblastic differentiation during rat mandibular development...
  31. Staphylococcal Pathogenesis and Gene Expression
    Jesse Wright; Fiscal Year: 2003
    ..The agr locus encodes a two-component system composed of AgrC and A, and its autoinducing ligand (ALP), encoded by AgrD and processed by AgrB; its primary function is to activate the expression of a regulatory RNA ..
  32. Molecular analysis of the dimeric F1/F0-ATP synthase
    Rosemary Stuart; Fiscal Year: 2006
    ..Isolation of the dimeric AlP synthase complex led to the identification of three new subunits of the complex...
  33. Mechanism of helicase translocation along ss DNA
    Christopher Fischer; Fiscal Year: 2003
    ..The focus of this proposal is to characterize the kinetic mechanism for AlP binding and hydrolysis by Rep monomers bound to ss DNA and to determine whether Rep monomers are, indeed, capable ..
  34. MODULATION OF TGF-BETA/BMP ACTIVITY IN DEVELOPMENT
    Kavita Arora; Fiscal Year: 2005
    ..We will approach this issue by investigating the phenotype and delineating the receptor specificity and signaling pathway utilized by a novel TGF-B related ligand Alp that we have recently characterized.
  35. Global vs. Focal Neuroimaging Markers of Dementia Risk
    Caterina Rosano; Fiscal Year: 2007
    ..markers of Alzheimer Disease (AD) using an automated brain MRI reading technique, the automated labeling pathway (ALP)...
  36. STEROID INDUCED CHANGES IN CULTURED MALIGNANT CELLS
    GEORGE MELNYKOVYCH; Fiscal Year: 1993
    This research project is an integrated study of the effects of alkylphospholipids (ALP) and glucocorticoid steroid dexamethasone on cell lines derived from malignant tumors...
  37. ATHEROSCLEROTIC LESION PHANTOM (ALP) FOR MRI/A
    Thomas Burke; Fiscal Year: 2006
    ..Advanced ALP phantoms, properly employed, will help achieve statistically conclusive results speeding the development of ..
  38. Structural Analysis of the ATP Synthase Membrane Domain
    Mark Girvin; Fiscal Year: 2004
    The F1F0 ATP synthase is responsible for synthesizing the vast majority of cellular AlP. Not surprisingly, deleterious mutations in genes of the ATP synthase lead to inherited disorders, especially of nerves and muscles...
  39. APOPTOSIS AND A NEW ADAPTER MOLECULE PATHWAY IN GLIOMA
    Oliver Bogler; Fiscal Year: 2004
    ..SETA binds AlP!, a regulator of apoptosis and binding partner of ALG-2, which is itself required for apoptosis...
  40. Targeting Gene Therapy to Bladder Cancer
    GRAEME DOUGHERTY; Fiscal Year: 2005
    ..in which alternative splicing is used as a means of targeting the expression of the enzyme alkaline phosphatase (ALP) to tumor cells in vivo...
  41. RAPAMYCIN BLOCKADE OF PROTEIN PHOSPHATASE SIGNALING
    DAVID BRAUTIGAN; Fiscal Year: 2007
    ..Define the structural determinants required for interaction between human alpha-4 (TAP42) and its binding partner AlP (TIP41) using transient expression of truncated and mutated proteins and co-precipitation...
  42. A BABOON MODEL FOR THE GENETICS OF CORTICAL BONE MATERIAL PROPERTIES
    LORENA HAVILL; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  43. Group B Strep Alp Protein-Epithelial Cell Interaction
    MIRIAM BARON BARSHAK; Fiscal Year: 2008
    ..These data support a hypothesis that Alps trigger actin-dependent internalization of GBS through interaction of an Alp N-terminal domain with an epithelial receptor. The specific aims of this proposal are 1...
  44. TWO X-LINKED GENES THAT REGULATE MINERAL HOMEOSTASIS
    Michael Whyte; Fiscal Year: 2002
    ....
  45. Regulation of Vascular Calcification in Diabetes
    XUENING CHEN; Fiscal Year: 2007
    ....
  46. OSTEOCALCIN SYNTHESIS AND CATABOLISM
    Caren Gundberg; Fiscal Year: 2007
    ..Osteoclast and/or osteoblast progenitors will be evaluated in bone marrow cells. ..
  47. Characterization of Familial Myopathy & Paget Disease
    Virginia Kimonis; Fiscal Year: 2005
    ..Elucidation of the genetic defect will help us understand the pathogenesis of this multifaceted disorder and hopefully result in specific therapy. ..
  48. GENE CAUSING PAGET & LIMB-GIRDLE MUSCULAR DYSTROPHY
    Virginia Kimonis; Fiscal Year: 2003
    ..Delineation of the genetic component responsible for the LGMD/PDB phenotype should promise similar insight and facilitate in the design of novel treatment protocols for the two disorders. ..
  49. REGULATION OF BONE REMODELING BY MEGAKARYOCYTES
    Mark Horowitz; Fiscal Year: 2009
    ..Such information would be applicable to a wide variety of skeletal defects including, post-menopausal osteoporosis, age-related osteopenia, fracture repair, and extended survival of prosthetic implants. ..
  50. CONTROL OF OSTEOGENESIS AND ADIPOGENESIS BY EBF
    Mark C Horowitz; Fiscal Year: 2010
    ..Such information would be applicable to a wide variety of skeletal defects including age-related osteopenia, post-menopausal osteoporosis, fracture repair, and extended survival of prosthetic implants. ..
  51. Bone Repair by Allogenic MSC in Non-ablated Animal
    Jueren Lou; Fiscal Year: 2004
    ..2. To investigate the fate of implanted allogeneic MSC in femur defect site of non-ablated rats. The ultimate goal of this proposal is to develop percutaneous injection procedure to facilitate bone repair. ..
  52. Sequential Release of Growth Factors for Bone Formation
    Jonathan Leach; Fiscal Year: 2004
    ..Vascularization and bone formation will be compared to several control groups. ..
  53. Regulation of Osteoclast Differentiation by Pax5
    Mark Horowitz; Fiscal Year: 2007
    ..Such information would be applicable to a wide variety of skeletal defects including, post-menopausal osteoporosis, age-related osteopenia, fracture repair, and extended survival of prosthetic implants. ..
  54. GENERAL CLINICAL RESEARCH CENTERS ANNUAL MEETING
    Paul Watkins; Fiscal Year: 2006
    ..abstract_text> ..
  55. Development of a Multi-phased Scaffold for Soft Tissue to Bone Integration
    Helen Lu; Fiscal Year: 2006
    ..abstract_text> ..
  56. ANALYSIS OF GOLGI MEMBRANE PROTEIN LOCALIZATION IN YEAST
    Steven Nothwehr; Fiscal Year: 2003
    ..Finally, several genes have been identified in genetic screens as defective in Golgi retention of proteins, and four of these will be investigated in further detail: grd20, grd21, grd22 and grd23. ..
  57. PI3K in LPS-induced coagulation and inflammation
    James Luyendyk; Fiscal Year: 2006
    ..Ultimately, characterization of the involvement of this pathway in LPS-induced inflammation may allow for development of novel strategies that can be used to treat sepsis. [unreadable] [unreadable] [unreadable]..
  58. POSTRECEPTOR DYSREGULATION IN DEPRESSION
    Yogesh Dwivedi; Fiscal Year: 2004
    ..abstract_text> ..
  59. Regulation of heme uptake in intestinal epithelial cells
    Aliye Uc; Fiscal Year: 2007
    ..heme uptake pathways will have a great impact in understanding disorders associated with iron overload (hereditary hemochromatosis, iron overload secondary to blood transfusions) and nutritional iron deficiency [unreadable] [unreadable]..
  60. Androgen action in bone: Overexpression of AR
    Kristine M Wiren; Fiscal Year: 2010
    ..These studies will identify specific molecular events/pathways influenced by androgen treatment in bone, and should lead to an improved understanding of mechanisms that influence adult bone size and quality. ..
  61. Regulation of Heme Uptake and Transport in Caco-2 Cells
    Aliye Uc; Fiscal Year: 2007
    ..g. hereditary hemochromatosis, iron overload secondary to blood transfusions) and explore the role of intestinal epithelial cell bi-directional heme movement on the regulation of iron stores. ..
  62. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2010
    ..The goal of this application is to fully characterize pancreatic involvement in our novel CF pig model and to better understand the pathophysiological mechanisms leading to PI in CF. ..
  63. Validating microRNA Analysis in Human Postmortem Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  64. FURANOCOUMARINS AND DRUGS EFFECT ON CYP3A4
    Paul Watkins; Fiscal Year: 2007
    ..abstract_text> ..
  65. Small RNAs in skeletogenesis
    Tatsuya Kobayashi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  66. Signal Transduction Mechanisms in Suicide Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..abstract_text> ..
  67. Breast Cancer Prevention and Treatment with Noni juice
    Mian Ying Wang; Fiscal Year: 2007
    ..The latency, multiplicity, volume of tumors, and the survivor rate of animals at the end of experiment will be evaluated in different groups. ..