N-cadherin

Summary

Gene Symbol: N-cadherin
Description: cadherin 2
Alias: CD325, CDHN, CDw325, NCAD, cadherin-2, N-cadherin 1, cadherin 2, type 1, N-cadherin (neuronal), calcium-dependent adhesion protein, neuronal, neural cadherin
Species: human

Top Publications

  1. ncbi Identification of mammalian and invertebrate analogues of the avian calcium-dependent cell adhesion protein N-cadherin with synthetic-peptide directed antibodies against a conserved cytoplasmic domain
    L A Lagunowich
    Department of Anatomy, Thomas Jefferson University, Philadelphia, PA 19107
    Biochem Biophys Res Commun 172:313-20. 1990
  2. ncbi Isolation and characterization of the promoter region of the chicken N-cadherin gene
    B Li
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, OH 45267 0521, USA
    Gene 191:7-13. 1997
  3. ncbi N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane
    James K Wahl
    University of Nebraska Medical Center, College of Dentistry and Eppley Cancer Center, Omaha, Nebraska 68198 7696, USA
    J Biol Chem 278:17269-76. 2003
  4. ncbi Drosophila N-cadherin functions in the first stage of the two-stage layer-selection process of R7 photoreceptor afferents
    Chun Yuan Ting
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 132:953-63. 2005
  5. ncbi Traction forces exerted through N-cadherin contacts
    Arthur Ganz
    INSERM, U706, Paris, F 75005 France
    Biol Cell 98:721-30. 2006
  6. doi Calsenilin regulates presenilin 1/γ-secretase-mediated N-cadherin ε-cleavage and β-catenin signaling
    Changhwan Jang
    Ilsong Institute of Life Science, Hallym University, 1605 4 Gwanyang dong, Dongan Gu, Anyang, Gyeonggi do 431 060, Republic of Korea
    FASEB J 25:4174-83. 2011
  7. doi N-cadherin mediates angiogenesis by regulating monocyte chemoattractant protein-1 expression via PI3K/Akt signaling in prostate cancer cells
    Arun Kumar Nalla
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA
    Exp Cell Res 317:2512-21. 2011
  8. ncbi IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli
    Manisha Sharma
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 282:8545-56. 2007
  9. ncbi GSK3beta activity modifies the localization and function of presenilin 1
    Kengo Uemura
    Horizontal Medical Research Organization, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Biol Chem 282:15823-32. 2007
  10. pmc Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1
    Yasushi Shintani
    Department of Oral Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Cell Biol 180:1277-89. 2008

Research Grants

  1. Mechanisms of N-Cadherin Mediated Breast CA Metastasis
    Rachel Hazan; Fiscal Year: 2005
  2. Cadherin Mediated Cell-Cell Interactions in the Bone Microenvironment
    Roberto Civitelli; Fiscal Year: 2013
  3. Signals Regulating SAG Development
    James A Marrs; Fiscal Year: 2010
  4. An investigation of guidance mechanisms regulating neuronal migration
    Sarah J Wanner; Fiscal Year: 2013
  5. Mechanism of differential adhesion by protocadherin-cadherin complexes
    JAMES DAVID JONTES; Fiscal Year: 2013
  6. Axon-glial interactions mediating axonal regeneration
    Toby A Ferguson; Fiscal Year: 2013
  7. SWI/SNF & Yolk Sac Development
    Terry Magnuson; Fiscal Year: 2010
  8. CADHERIN REGULATION OF OSTEOBLAST FUNCTION
    Roberto Civitelli; Fiscal Year: 2004
  9. DEVELOPMENT OF MULTIFUNCTIONAL CONTRAST AGENTS
    Lajos Balogh; Fiscal Year: 2006
  10. BRAINS RULE! NEUROSCIENCE EXPOSITIONS
    Andrea Zardetto Smith; Fiscal Year: 2004

Detail Information

Publications227 found, 100 shown here

  1. ncbi Identification of mammalian and invertebrate analogues of the avian calcium-dependent cell adhesion protein N-cadherin with synthetic-peptide directed antibodies against a conserved cytoplasmic domain
    L A Lagunowich
    Department of Anatomy, Thomas Jefferson University, Philadelphia, PA 19107
    Biochem Biophys Res Commun 172:313-20. 1990
    ..We produced a monospecific polyclonal antiserum, C-NCAD(838-856), to a synthetic peptide corresponding to a portion of the highly conserved c-terminal cytoplasmic domain ..
  2. ncbi Isolation and characterization of the promoter region of the chicken N-cadherin gene
    B Li
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, OH 45267 0521, USA
    Gene 191:7-13. 1997
    ....
  3. ncbi N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane
    James K Wahl
    University of Nebraska Medical Center, College of Dentistry and Eppley Cancer Center, Omaha, Nebraska 68198 7696, USA
    J Biol Chem 278:17269-76. 2003
    ..These data suggest that a core N-cadherin-catenin complex assembles in the endoplasmic reticulum or Golgi compartment and is transported to the plasma membrane where linkage to the actin cytoskeleton can be established...
  4. ncbi Drosophila N-cadherin functions in the first stage of the two-stage layer-selection process of R7 photoreceptor afferents
    Chun Yuan Ting
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 132:953-63. 2005
    ..N-cadherin is required in the first stage for R7 growth cones to reach and remain in the R7-temporary layer. The Ncad gene contains three pairs of alternatively spliced exons and encodes 12 isoforms...
  5. ncbi Traction forces exerted through N-cadherin contacts
    Arthur Ganz
    INSERM, U706, Paris, F 75005 France
    Biol Cell 98:721-30. 2006
    ..The present study focuses on the determination of force transduction through cadherins at a single cell level...
  6. doi Calsenilin regulates presenilin 1/γ-secretase-mediated N-cadherin ε-cleavage and β-catenin signaling
    Changhwan Jang
    Ilsong Institute of Life Science, Hallym University, 1605 4 Gwanyang dong, Dongan Gu, Anyang, Gyeonggi do 431 060, Republic of Korea
    FASEB J 25:4174-83. 2011
    ..cleavage of N-cadherin, which results in the significant accumulation of N-cadherin C-terminal fragment 1 (Ncad/CTF1), the reduction of cytoplasmic Ncad/CTF2 release, and a deceleration of PS1-CTF delivery to the cell surface...
  7. doi N-cadherin mediates angiogenesis by regulating monocyte chemoattractant protein-1 expression via PI3K/Akt signaling in prostate cancer cells
    Arun Kumar Nalla
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA
    Exp Cell Res 317:2512-21. 2011
    ..Our data demonstrated that N-cadherin in prostate cancer cell mediates cell-cell adhesion and regulates MCP-1 expression via the PI3K/Akt signaling pathway...
  8. ncbi IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli
    Manisha Sharma
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 282:8545-56. 2007
    ....
  9. ncbi GSK3beta activity modifies the localization and function of presenilin 1
    Kengo Uemura
    Horizontal Medical Research Organization, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Biol Chem 282:15823-32. 2007
    ....
  10. pmc Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1
    Yasushi Shintani
    Department of Oral Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Cell Biol 180:1277-89. 2008
    ..Both receptor complexes rely on the p130 Crk-associated substrate scaffold. Interestingly, Rap1, but not Rho family guanosine triphosphatases, is required for the response to collagen I...
  11. ncbi The green tea compound, (-)-epigallocatechin-3-gallate downregulates N-cadherin and suppresses migration of bladder carcinoma cells
    Kimberly M Rieger-Christ
    Cell and Molecular Biology Laboratory, Robert E Wise Research and Education Institute, Lahey Clinic Medical Center, 31 Mall Road, Burlington, Massachusetts 01805, USA
    J Cell Biochem 102:377-88. 2007
    ..Continuous administration of EGCG to mice revealed significant inhibition of tumor growth in vivo indicating a possible preventative role for green tea in bladder cancer...
  12. ncbi Cadherins are regulated by Ep-CAM via phosphaditylinositol-3 kinase
    Manon J Winter
    Department of Pathology, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Mol Cell Biochem 302:19-26. 2007
    ..The Pi3K activity shuttled from N-cadherin to Ep-CAM. From our results, we conclude that Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells...
  13. ncbi Extrajunctional distribution of N-cadherin in cultured human endothelial cells
    D Salomon
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Cell Sci 102:7-17. 1992
    ..Comparison of this pattern with the discrete junctional labeling obtained with the pan-cadherin antibody suggests that different cadherins, co-expressed in the same endothelial cells, may undergo differential surface distribution...
  14. pmc Human N-cadherin: nucleotide and deduced amino acid sequence
    R A Reid
    Becton Dickinson and Company Research Center, Research Triangle Park, NC 27709
    Nucleic Acids Res 18:5896. 1990
  15. pmc Functional cis-heterodimers of N- and R-cadherins
    W S Shan
    Department of Biochemistry and Molecular Biology, Program in Cell Adhesion, The Mount Sinai School of Medicine, New York University, New York 10029, USA
    J Cell Biol 148:579-90. 2000
    ..The present study provides a novel paradigm for cadherin interaction whereby selective cis-heterodimer formation may generate new functional units to mediate cell-cell adhesion...
  16. ncbi A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor
    Kimita Suyama
    Derald H Ruttenberg Cancer Center, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cancer Cell 2:301-14. 2002
    ..These results suggest that protection of the FGFR-1 from ligand-induced downregulation by N-cadherin enhances receptor signaling and provides a mechanism by which tumor cells can acquire metastatic properties...
  17. ncbi Cadherin switch in tumor progression
    Rachel B Hazan
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Ann N Y Acad Sci 1014:155-63. 2004
    ..Here, we summarize the various aspects of the E- to N-cadherin switching in epithelial carcinomas and its potential impact on metastatic progression...
  18. ncbi Neoexpression of N-cadherin in E-cadherin positive colon cancers
    Erika Rosivatz
    Institut für Pathologie der TU, Munchen, Germany
    Int J Cancer 111:711-9. 2004
    ....
  19. pmc Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion
    Hajime Yano
    Department of Molecular Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    J Cell Biol 166:283-95. 2004
    ..Our analyses simultaneously exemplified the essential role of Fak in the maintenance of cell-cell adhesions in collective cell migration, a type of migration occurring in embryonic development and carcinoma invasion...
  20. ncbi Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-beta or wounding
    Olivier De Wever
    Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium
    J Cell Sci 117:4691-703. 2004
    ..Taken together, our study identifies a new mechanism in which cancer cells contribute to the coordination of invasion of stromal myofibroblasts...
  21. ncbi Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition
    Masato Maeda
    Department of Oral Biology College of Dentistry, University of Nebraska Medical Center, Omaha, NE 68198 7696, USA
    J Cell Sci 118:873-87. 2005
    ..Together, these data suggest that cadherin switching is necessary for increased motility but is not required for the morphological changes that accompany EMT...
  22. pmc Gingipains from Porphyromonas gingivalis W83 induce cell adhesion molecule cleavage and apoptosis in endothelial cells
    Shaun M Sheets
    Department of Biochemistry and Microbiology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
    Infect Immun 73:1543-52. 2005
    ..Taken together, these results indicate that gingipains from P. gingivalis can alter cell adhesion molecules and induce endothelial cell death, which could have implications for the pathogenicity of this organism...
  23. ncbi N-cadherin-dependent cell-cell contacts promote human saphenous vein smooth muscle cell survival
    Evgenia Koutsouki
    Bristol Heart Institute, Bristol Royal Infirmary, Bristol, UK
    Arterioscler Thromb Vasc Biol 25:982-8. 2005
    ..Vascular smooth muscle cell (VSMC) apoptosis is thought to contribute to atherosclerotic plaque instability. Cadherin mediates calcium-dependent homophilic cell-cell contact. We studied the role of N-cadherin in VSMC apoptosis...
  24. pmc Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion
    Keiran S M Smalley
    Wistar Institute, 3601 Spruce St, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 166:1541-54. 2005
    ....
  25. pmc Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the beta-catenin signaling pathway
    Jianfei Qi
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada
    Mol Biol Cell 16:4386-97. 2005
    ..Transendothelial migration was compromised in cells expressing a dominant-negative form of beta-catenin, thus supporting a regulatory role of beta-catenin signaling in this process...
  26. ncbi N-cadherin expression in breast cancer: correlation with an aggressive histologic variant--invasive micropapillary carcinoma
    Chandandeep Nagi
    Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA
    Breast Cancer Res Treat 94:225-35. 2005
    ..005), whereas such changes were not significant in the non-MPAP group (p = 0.10). Thus, N-cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression...
  27. ncbi N-cadherin as a novel prognostic marker of progression in superficial urothelial tumors
    Isabelle Lascombe
    Tissue and Cell Biology Engineering, Besancon, France
    Clin Cancer Res 12:2780-7. 2006
    ..The purpose of this study was to investigate whether N-cadherin expression was associated with the bladder tumor progression...
  28. ncbi Up-regulation of gastric cancer cell invasion by Twist is accompanied by N-cadherin and fibronectin expression
    Zhou Yang
    Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China
    Biochem Biophys Res Commun 358:925-30. 2007
    ..Taken together, our results suggest that Twist regulates cell motility and invasion in gastric cancer cell lines, probably through the N-cadherin and fibronectin production...
  29. doi Differential expression of neural-cadherin in pulmonary epithelial tumours
    D L Zynger
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Histopathology 52:348-54. 2008
    ..The aim was to determine whether evaluation of N-cadherin in pulmonary tumours might assist in identifying lesions with more aggressive potential...
  30. doi Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines
    Herve Wallerand
    Department of Urology, CHU Pellegrin, Victor Segalen School of Medicine, Bordeaux, France
    Urol Oncol 28:180-8. 2010
    ....
  31. doi The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain
    Helena Grinberg-Rashi
    Cancer Research Center and Pathology Department, Sheba Medical Center, Ramat Gan, Israel
    Clin Cancer Res 15:1755-61. 2009
    ..We hypothesized that the expression of genes in primary NSCLC tumors could predict brain metastasis and be used for identification of high-risk patients, who may benefit from prophylactic therapy...
  32. pmc N-cadherin knock-down decreases invasiveness of esophageal squamous cell carcinoma in vitro
    Ke Li
    Department of Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China
    World J Gastroenterol 15:697-704. 2009
    ....
  33. pmc Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance
    Hiroshi Tanaka
    Department of Urology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Nat Med 16:1414-20. 2010
    ..These data indicate that N-cadherin is a major cause of both prostate cancer metastasis and castration resistance. Therapeutic targeting of this factor with monoclonal antibodies may have considerable clinical benefit...
  34. pmc Epithelial N-cadherin and nuclear β-catenin are up-regulated during early development of human lung
    Riitta Kaarteenaho
    Institute of Clinical Medicine, Department of Internal Medicine Respiratory Research Unit, Centre of Excellence in Research, University of Oulu and Oulu University Hospital, Oulu, Finland
    BMC Dev Biol 10:113. 2010
    ..The aim of this study was to analyze the cell-specific expression of E- and N-cadherin and β-catenin in developing human lung tissues from 12 to 40 weeks of gestation...
  35. doi Inverse association between miR-194 expression and tumor invasion in gastric cancer
    Yongxi Song
    Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, People s Republic of China
    Ann Surg Oncol 19:S509-17. 2012
    ..MiR-194 has been shown to be specifically expressed in the human gastrointestinal tract and may play an antimetastatic role in primary liver cancer cells. However, the role of miR-194 in gastric cancer is still unclear...
  36. doi Twist modulates human trophoblastic cell invasion via regulation of N-cadherin
    York Hunt Ng
    Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V5
    Endocrinology 153:925-36. 2012
    ..Similarly, a reduction in N-cadherin decreased the invasive capacity of HTR-8/SVneo cells. Twist is an upstream regulator of N-cadherin-mediated invasion of human trophoblastic cells...
  37. doi Positive expression of LSD1 and negative expression of E-cadherin correlate with metastasis and poor prognosis of colon cancer
    Ding Jie
    Department of Gastrointestinal Surgery, Guizhou Provincial People s Hospital, Guiyang, 550002, Guizhou Province, China
    Dig Dis Sci 58:1581-9. 2013
    ..The first identified lysine-specific demethylase, LSD1, plays an important role in the metastatic progression of several types of cancer...
  38. ncbi Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression
    Yasushi Shintani
    Department of Oral Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Cancer Res 66:11745-53. 2006
    ..We show that JNK1 is activated in response to collagen I, which increases tumorigenesis by up-regulating N-cadherin expression and by increasing motility...
  39. doi Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin
    Stephen N Hartland
    MRC University of Edinburgh Centre for Inflammation Research, Edinburgh, UK
    Liver Int 29:966-78. 2009
    ..This is accompanied by HSC apoptosis. In this study, we examine a potential mechanism whereby MMP activity might induce HSC apoptosis by cleaving N-cadherin at the cell surface...
  40. pmc Epstein-Barr virus latent membrane protein-1 effects on junctional plakoglobin and induction of a cadherin switch
    Kathy H Y Shair
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Cancer Res 69:5734-42. 2009
    ..Low levels of plakoglobin were also detected in human NPC tissues. These findings reveal that the effects of LMP1 on junctional plakoglobin and the initiation of a cadherin switch likely contribute to metastasis of NPC...
  41. ncbi Signal transduction from N-cadherin increases Bcl-2. Regulation of the phosphatidylinositol 3-kinase/Akt pathway by homophilic adhesion and actin cytoskeletal organization
    Nhan L Tran
    Cancer Biology Graduate Program, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
    J Biol Chem 277:32905-14. 2002
    ..We propose that N-cadherin homophilic adhesion can initiate anti-apoptotic signaling, which enhances the Akt cell survival pathway in metastatic cancer...
  42. doi Expression analysis of epithelial cadherin and related proteins in IBH-6 and IBH-4 human breast cancer cell lines
    Lara Lapyckyj
    Instituto de Biologia y Medicina Experimental, National Research Council of Argentina CONICET, C1428ADN Buenos Aires, Argentina
    J Cell Physiol 222:596-605. 2010
    ..Several molecules associated with down-regulation of E-cadherin have been described, within them neural cadherin, Twist and dysadherin...
  43. pmc Neural-cadherin expression associated with angiogenesis in non-small-cell lung cancer patients
    T Nakashima
    Second Department of Surgery, Kagawa Medical University, 1750 1 Miki cho, Kita gun, Japan
    Br J Cancer 88:1727-33. 2003
    ..Thus, N-cadherin also might play a specific role in undifferentiated large cell carcinomas...
  44. doi Neural cadherin is expressed in human gametes and participates in sperm-oocyte interaction events
    C I Marín-Briggiler
    Instituto de Biologia y Medicina Experimental, National Research Council of Argentina CONICET, University of Buenos Aires, Buenos Aires, Argentina
    Int J Androl 33:e228-39. 2010
    b>Neural cadherin (N-cadherin) is a transmembrane glycoprotein involved in calcium-dependent cell-cell adhesion and signalling events...
  45. ncbi Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptor
    K Uemura
    Horizontal Medical Research Organization, Kyoto University Graduate School of Medicine, Kyoto, Japan 606 8507
    Neuroscience 145:5-10. 2007
    ..cleaved by ADAM10 and PS1/gamma-secretase, producing a cytoplasmic fragment, N-cadherin C-terminal fragment (Ncad/CTF2) after NMDA receptor stimulation [Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, Siman R, Robakis NK (2003)..
  46. ncbi Structural basis of calcium-induced E-cadherin rigidification and dimerization
    B Nagar
    Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Nature 380:360-4. 1996
    ..aligned in a parallel orientation, the interactions between them differ significantly from those found in the neural cadherin (N-cadherin) N-terminal domain (NCD1) structure...
  47. ncbi Epithelial-type and neural-type cadherin expression in malignant noncarcinomatous neoplasms with epithelioid features that involve the soft tissues
    William B Laskin
    Department of Pathology, Northwestern University Medical School, Chicago, IL 60611 3053, USA
    Arch Pathol Lab Med 126:425-31. 2002
    Transmembrane adhesion molecules, epithelial-type cadherin (ECAD) and neural-type cadherin (NCAD), help in regulating transformations between epithelial and mesenchymal cells in the developing embryo and in maintaining the epithelioid ..
  48. pmc Cranial sensory ganglia neurons require intrinsic N-cadherin function for guidance of afferent fibers to their final targets
    A Lamora
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Neuroscience 159:1175-84. 2009
    ..Together, our in vivo data reveal a novel role for cdh2 in the establishment of circuits by peripheral sensory neurons...
  49. doi The association of elasticity indexes of ascending aorta and the presence and the severity of coronary artery disease
    Ali Yildiz
    Department of Cardiology, School of Medicine, Harran University, Sanliurfa, Turkey
    Coron Artery Dis 19:311-7. 2008
    ..To investigate the association between elasticity indexes of aorta and severity of coronary artery disease (CAD) in patients with stable CAD...
  50. doi Retinal patterning by Pax6-dependent cell adhesion molecules
    Elisabeth Rungger-Brandle
    Cell Biology Laboratory, University Eye Clinic, HUG, Rue Alcide Jentzer, Geneva, Switzerland
    Dev Neurobiol 70:764-80. 2010
    ..by morpholino antisense molecules in Xenopus embryos and knockdown of maternal N-cadherin (mNcad), N-cadherin (Ncad) and neural cell adhesion molecule (NCAM) produce similar phenotypes...
  51. ncbi Butyrylcholinesterase K variants increase the risk of coronary artery disease in the population of western Iran
    A Vaisi-Raygani
    Department of Clinical Biochemistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
    Scand J Clin Lab Invest 68:123-9. 2008
    ..They were matched and randomly assigned into four groups: CAD+T2DM+ (CAD/T2DM), CAD+DM(-) (CAD/ND), CAD(-)DM+ (T2DM/NCAD) and CAD(-)DM(-)(control). The BCHE-K variant was detected by PCR-RFLP...
  52. pmc Differential function of N-cadherin and cadherin-7 in the control of embryonic cell motility
    S Dufour
    UMR 144, Compartimentation et Dynamique Cellulaires, Centre National de la Recherche Scientifique et Institut Curie, 75248 Paris Cedex 05, France
    J Cell Biol 146:501-16. 1999
    ..the prototypes of type I and type II cadherin, induced cell-cell adhesion in murine sarcoma 180 transfectants, Ncad-1 and cad7-29, respectively...
  53. ncbi Comparative expression patterns of T-, N-, E-cadherins, beta-catenin, and polysialic acid neural cell adhesion molecule in rat cochlea during development: implications for the nature of Kölliker's organ
    Lionel Simonneau
    Laboratoire de Neurobiologie de l Audition Plasticité Synaptique, Institut National de la Santé et de la Recherche Médicale U254, Universite Montpellier I, 34090 Montpellier, France
    J Comp Neurol 459:113-26. 2003
    ..CAMs) during rat cochlea ontogeny, from embryo day 16 to adulthood, with the use of immunohistochemistry: neural cadherin (N-cad) and polysialic acid neural CAM (PSA-NCAM) as two different neural CAM paradigms; epithelial cadherin (..
  54. doi Assessing the role of claudins in maintaining the integrity of epididymal tight junctions using novel human epididymal cell lines
    Evemie Dube
    INRS Institut Armand Frappier, University of Quebec, 531 Boulevard des Prairies, Laval, Quebec, Canada
    Biol Reprod 82:1119-28. 2010
    ..Disruption of CLDN1, CLDN3, CLDN4, and CLDN7 could, therefore, lead to epididymal dysfunction, resulting in male infertility...
  55. doi Mutations in N-cadherin and a Stardust homolog, Nagie oko, affect cell-cycle exit in zebrafish retina
    Masahiro Yamaguchi
    Developmental Neurobiology Unit, Okinawa Institute of Science and Technology OIST, Azatancha 1919 1, Onna, Okinawa 904 0412, Japan
    Mech Dev 127:247-64. 2010
    ..progenitor cells to the total number of retinal cells increases in the neurogenic stages in zebrafish n-cadherin (ncad) and nagie oko (nok) mutants, in which the apicobasal cell polarity and adherens junctions in the retinal ..
  56. ncbi Expression of adrenomedullin in human epicardial adipose tissue: role of coronary status
    Alina Silaghi
    INSERM U626, Aix Marseille Universite, Marseille Cedex 5, France
    Am J Physiol Endocrinol Metab 293:E1443-50. 2007
    ..of subcutaneous WAT (sWAT) and eWAT obtained from patients with coronary artery disease (CAD) or without CAD (NCAD)...
  57. doi Tubulobulbar complexes are intercellular podosome-like structures that internalize intact intercellular junctions during epithelial remodeling events in the rat testis
    J Nelle S Young
    Department of Cellular and Physiological Sciences, Faculty of Medicine, Life Sciences Centre, The University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Biol Reprod 80:162-74. 2009
    ..Our results are consistent with the conclusion that tubulobulbar complexes are podosome-like structures that are responsible for internalizing intact intercellular junctions during spermatogenesis...
  58. ncbi Identification of novel androgen response genes in prostate cancer cells by coupling chromatin immunoprecipitation and genomic microarray analysis
    K Takayama
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Oncogene 26:4453-63. 2007
    ..The present study would be powerful to extend our knowledge of the diversity of androgen genetic network and steroid action in prostate cancer cells...
  59. ncbi Seven genes from human chromosome 18 map to chromosome 24 in the bovine
    N J Larsen
    Department of Animal Sciences, University of Wisconsin, Madison 53706, USA
    Cytogenet Cell Genet 73:184-6. 1996
    ..These STSs were used for synteny mapping, and all seven genes were syntenic with markers of bovine chromosome (BTA) 24. The concordance with BTA 24 was at least 96.5% for all genes...
  60. doi Substrate-dependent regulation of carbon catabolism in marine sulfate-reducing Desulfobacterium autotrophicum HRM2
    Judith Amann
    Max Planck Institute for Marine Microbiology, Bremen, Germany
    J Mol Microbiol Biotechnol 18:74-84. 2010
    ..In summary, the different regulatory patterns displayed by Db. autotrophicum HRM2 at the tested metabolic levels point to a multi-layered regulatory network...
  61. ncbi Paraoxonase and arylesterase activities in coronary artery disease
    M Gur
    Harran University, Sanliurfa, Turkey
    Eur J Clin Invest 36:779-87. 2006
    ..Accordingly, the aim of the study was to investigate the paraoxonase, arylesterase activities and oxidative/anti-oxidative status in coronary artery disease (CAD) and their correlation with the extent of CAD...
  62. ncbi Plasma HDL-cholesterol has an effect on nitric oxide production and arachidonic acid metabolism in the platelet membranes of coronary heart disease patients without LDL-hypercholesterolemia
    P Tretjakovs
    Latvian Institute of Experimental and Clinical Medicine, Riga, Latvia
    Med Sci Monit 6:507-11. 2000
    ..To evaluate nitric oxide (NO) production and [3H]arachidonic acid (AA) incorporation into platelet membranes of coronary artery disease (CAD) patients with/without HDL-hypocholesterolemia...
  63. pmc Global comparative transcriptome analysis of cartilage formation in vivo
    Trevor L Cameron
    Murdoch Childrens Research Institute and Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville, Victoria 3052, Australia
    BMC Dev Biol 9:20. 2009
    ..Regulation of the onset of chondrogenesis is incompletely understood, and would be informed by comprehensive analyses of in vivo gene expression...
  64. pmc MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex
    Jill M Weimer
    UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Development 136:2965-75. 2009
    ....
  65. pmc Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes
    Ben M Minogue
    Tissue Injury and Repair, School of Biomedicine, Faculty of Medical and Human Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Arthritis Res Ther 12:R22. 2010
    ....
  66. pmc Integrated proteomics and genomics analysis reveals a novel mesenchymal to epithelial reverting transition in leiomyosarcoma through regulation of slug
    Jilong Yang
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Proteomics 9:2405-13. 2010
    ..An increase in Slug expression by pCMV6-XL5-Slug transfection decreased E-cadherin and increased vimentin and N-cadherin. Thus, MErT, which is mediated through regulation of Slug, is a clinically significant phenotype in leiomyosarcoma...
  67. doi Cell-cell adhesion in the prelaminar region of the optic nerve head: a possible target for ionic stress
    Francisco Javier Carreras
    Department of Surgery Ophthalmology, Faculty of Medicine, University of Granada, ES 18071 Granada, Spain
    Ophthalmic Res 42:106-11. 2009
    ..The intercellular junctions of the lining astrocytes mediated by cellular adhesion molecules (CAMs) may be the main targets for ionic stress...
  68. ncbi Regeneration in the adult mammalian CNS: guided by development
    I Aubert
    Laboratory of Genetics, Salk Institute, La Jolla, California 92037 1099, USA
    Curr Opin Neurobiol 5:625-35. 1995
    ..neurotrophic growth factor), growth cone guidance (netrins and semaphorins), axonal outgrowth and sorting (neural cadherin, polysialylated neural cell adhesion molecules, and L1), and neuronal connectivity (cell adhesion molecules, ..
  69. pmc Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers
    H Ohta
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Br J Cancer 100:389-98. 2009
    ..Our proposed extensive Hh-EMT signal pathway has the potential to an understanding of diffuse-type GC and to the development of new drugs...
  70. ncbi Multiple metastases from cutaneous malignant melanoma patients may display heterogeneous genomic and epigenomic patterns
    Katja Harbst
    Department of Oncology, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
    Melanoma Res 20:381-91. 2010
    ..These data are further corroborated by a switch in CDH1 and CDH2 expression between metastases from the same patient. In conclusion, our results provide evidence for different models of metastatic progression in melanoma...
  71. ncbi parachute/n-cadherin is required for morphogenesis and maintained integrity of the zebrafish neural tube
    Zsolt Lele
    Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 129:3281-94. 2002
    N-cadherin (Ncad) is a classical cadherin that is implicated in several aspects of vertebrate embryonic development, including somitogenesis, heart morphogenesis, neural tube formation and establishment of left-right asymmetry...
  72. ncbi Cadherin-2 participates in the morphogenesis of the zebrafish inner ear
    Sherry Babb-Clendenon
    Department of Medicine, Indiana University Medical Center, 950 West Walnut Street, Indianapolis, IN 46202, USA
    J Cell Sci 119:5169-77. 2006
    ..These findings demonstrate that Cdh2 selectively affects epithelial morphogenetic cell movements, particularly semicircular canal formation, during normal ear mophogenesis...
  73. ncbi Non-cardiac arterial disease in Catalonia: patient profiles and quality of clinical records by characteristics of the Vascular Surgery Unit
    M A Cairols Castellote
    Catalan Society of Angiology and Vascular Surgery, Barcelona, Spain
    Int Angiol 27:124-34. 2008
    Non-cardiac arterial disease (NCAD) is a frequent cause of hospital admission. The aim of this study was to investigate differences in patient profiles and clinical records as a function of the size of the Vascular Surgery Unit (VSU).
  74. pmc N-cadherin mediates plasticity-induced long-term spine stabilization
    Pablo Mendez
    Department of Neuroscience, University of Geneva, Faculty of Medicine, Geneva, Switzerland
    J Cell Biol 189:589-600. 2010
    ..this study, we combined repetitive imaging and a gain and loss of function approach to test the role of N-cadherin (NCad) on spine stability...
  75. pmc Surface expression of precursor N-cadherin promotes tumor cell invasion
    Deborah Maret
    Brain Tumour Research Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Neoplasia 12:1066-80. 2010
    The expression of N-cadherin (NCAD) has been shown to correlate with increased tumor cell motility and metastasis...
  76. ncbi Ventral neural cadherin, a novel cadherin expressed in a subset of neural tissues in the zebrafish embryo
    J I Franklin
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2790, USA
    Dev Dyn 206:121-30. 1996
    ..Here we describe a novel member of this gene family, zebrafish ventral neural cadherin (VN-cad). Multiple VN-cad transcripts are first detectable by Northern blots at 60% epiboly...
  77. ncbi Up-regulation of cadherin-2 and cadherin-4 in regenerating visual structures of adult zebrafish
    Q Liu
    Department of Biology, University of Akron, Akron, Ohio 44325 3908, USA
    Exp Neurol 177:396-406. 2002
    ..Our results suggest that both Cdh2 and Cdh4 may be important for regeneration of injured retinal ganglion cell axons...
  78. ncbi Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure
    Igor Kostetskii
    Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Circ Res 96:346-54. 2005
    ....
  79. pmc Ovo1 links Wnt signaling with N-cadherin localization during neural crest migration
    Sarah Piloto
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Development 137:1981-90. 2010
    ..target gene that controls migration of pigment precursors by regulating the intracellular movements of N-cadherin (Ncad). Ovo1 genetically interacts with Ncad and its depletion causes Ncad to accumulate inside cells...
  80. ncbi N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene
    F S Walsh
    Department of Experimental Pathology, UMDS, Guy s Hospital, London, England
    J Neurochem 55:805-12. 1990
    ..This is distinct from the E-cadherin locus on chromosome 16. Therefore, it is likely that the cadherins have evolved from a common precursor gene that has undergone duplication and migration to other chromosomal locations...
  81. ncbi Isolation and developmental expression of retinoic-acid-induced genes
    L J Jonk
    Hubrecht Laboratorium, Netherlands Institute for Developmental Biology, Utrecht
    Dev Biol 161:604-14. 1994
    ..In addition to the previously recognized genes encoding vimentin, heat stable antigen, neural cadherin, Hox-B2, F52/MacMARCKS, thymosin beta 4b, and the murine homolog of COUP-TF1, we identified 7 novel genes, 5 ..
  82. ncbi Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: an in vitro and in vivo study
    Nikki P Y Lee
    Population Council, New York, New York 10021, USA
    Biol Reprod 73:458-71. 2005
    ..These results illustrate that the CDH2/CATNB-mediated adhesion function in the testis is regulated, at least in part, via the NOS/cGMP/PRKG/CATNB pathway...
  83. ncbi Accentuated ovariectomy-induced bone loss and altered osteogenesis in heterozygous N-cadherin null mice
    Chung Fang Lai
    Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington School of Medicine, St Louis, Missouri 63110, USA
    J Bone Miner Res 21:1897-906. 2006
    ....
  84. ncbi Cadherin expression in the developing mouse olfactory system
    Michael R Akins
    Interdepartmental Neuroscience Graduate Program, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
    J Comp Neurol 501:483-97. 2007
    ..We conclude that cadherin proteins in the developing olfactory system are positioned to underlie the formation of the odorant map and local circuits within the OB...
  85. ncbi Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling
    Michael B Major
    Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA
    Science 316:1043-6. 2007
    ..These data provide a possible mechanistic explanation for the tumor suppressor activity of WTX...
  86. ncbi The prognostic value of cadherin switch in bladder cancer
    Tobias Jager
    Department of Urology, University of Duisburg Essen, 45147 Essen, Germany
    Oncol Rep 23:1125-32. 2010
    ..The poor patient prognosis in N-cadherin-negative muscle-invasive tumors indicates an alternative, N-cadherin-independent way in bladder cancer progression...
  87. doi The cleavage of N-cadherin is essential for chondrocyte differentiation
    Shigeto Nakazora
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu City, Mie 514 8507, Japan
    Biochem Biophys Res Commun 400:493-9. 2010
    ..These results suggested that the cleavage of N-cadherin is essential for chondrocyte differentiation...
  88. pmc Smad7 restricts melanoma invasion by restoring N-cadherin expression and establishing heterotypic cell-cell interactions in vivo
    Kyle A Divito
    Department of Biochemistry and Molecular Biology, Georgetown University School of Medicine Washington, DC, USA
    Pigment Cell Melanoma Res 23:795-808. 2010
    ..We propose that Smad7 suppresses β-catenin degradation and promotes interaction with N-cadherin, stabilizing association with neighboring dermal fibroblasts, thus mitigating invasion...
  89. doi N-cadherin and β1-integrins cooperate during the development of the enteric nervous system
    Florence Broders-Bondon
    Institut Curie CNRS UMR144, Paris, France
    Dev Biol 364:178-91. 2012
    ..N-cadherin-null (Ncad-/-) ENCC exhibited a delayed colonization in the developing gut at E12...
  90. doi Clinical implications of N-cadherin expression in gastric cancer
    Takahito Kamikihara
    Digestive Surgery, Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
    Pathol Int 62:161-6. 2012
    ..However, neo N-cadherin expression significantly affected patient's survival in gastric cancer. Therefore, we concluded that neo N-cadherin expression may be a useful prognostic marker independent of E-cadherin expression...
  91. doi Protein kinase casein kinase 2-mediated upregulation of N-cadherin confers anoikis resistance on esophageal carcinoma cells
    Hyeonseok Ko
    Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul, Korea
    Mol Cancer Res 10:1032-8. 2012
    ..We conclude that high intracellular PKCK2 activity confers anoikis resistance on esophageal cancer cells by inducing E- to N-cadherin switching...
  92. pmc GSK3β inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylation
    Jobin K John
    Department of Molecular Oncology, The Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Invest Dermatol 132:2818-27. 2012
    ..These studies suggest the potential therapeutic utility of inhibiting GSK3β in defined subsets of melanoma...
  93. pmc Distinct mesenchymal alterations in N-cadherin and E-cadherin positive primary renal epithelial cells
    Christof Keller
    Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
    PLoS ONE 7:e43584. 2012
    ..Renal tubular epithelial cells of proximal and distal origin differ markedly in their physiological functions. Therefore, we hypothesized that they also differ in their capacity to undergo epithelial to mesenchymal alterations...
  94. pmc N-cadherin sustains motility and polarity of future cortical interneurons during tangential migration
    Camilla Luccardini
    Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 839, Institut du Fer a Moulin, 75005 Paris, France, Universite Pierre et Marie Curie Paris 6, 75005 Paris, France, Graduate School of Frontier Biosciences, Osaka University, Osaka 565 0871, Japan, Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London, London, WC1E 6BT, United Kingdom, and Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
    J Neurosci 33:18149-60. 2013
    ..Altogether, these results identify N-cadherin as a pivotal adhesion substrate that activates cell motility in future cortical interneurons and maintains cell polarity over their long-distance migration to the developing cortex. ..
  95. pmc Role of endothelial cell septin 7 in the endocytosis of Candida albicans
    Quynh T Phan
    Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
    MBio 4:e00542-13. 2013
    ..albicans infection, SEPT7 forms a complex with endothelial cell N-cadherin, is required for normal accumulation of N-cadherin around C. albicans hyphae, and is necessary for maximal endocytosis of the organism...
  96. doi A ROS/STAT3/HIF-1α signaling cascade mediates EGF-induced TWIST1 expression and prostate cancer cell invasion
    Kyung Hwa Cho
    Department of Pharmacology, Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon, Republic of Korea
    Prostate 74:528-36. 2014
    ..The purpose of this study is to determine the underlying mechanism of EGF-induced TWIST1 expression and prostate cancer invasion...
  97. pmc Restricted expression of classic cadherins in the spinal cord of the chicken embryo
    Juntang Lin
    Institute of Anatomy I, University of Jena School of Medicine Jena University Hospital Jena, Germany Xinxiang Medical University Xinxiang, Henan, China
    Front Neuroanat 8:18. 2014
    ..The highly regulated spatiotemporal expression patterns of the classic cadherins indicate that these genes potentially play multiple and diverse roles during the development of the SP and its surrounding tissues. ..
  98. doi Strong correlation between N-cadherin and CD133 in breast cancer: role of both markers in metastatic events
    Carolin Bock
    Department of Obstetrics and Gynaecology, Campus Innenstadt, Ludwig Maximilians University Hospital, Maistraße 11, 80337, Munich, Germany
    J Cancer Res Clin Oncol 140:1873-81. 2014
    ..Our main goal was to investigate the role of the EMT marker, N-cadherin, and of the stem cell marker, CD133, in breast cancer...
  99. pmc Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines
    Natascia Marino
    Women s Malignancies Branch, Center for Cancer Research, National Cancer Institute, Building 37 Room 1126, 37 Convent Drive, Bethesda, MD, 20892, USA
    Clin Exp Metastasis 31:771-86. 2014
    ..045 and p = 0.009 respectively). This study demonstrates that previously unrecognized genes are inversely related to the expression of multiple MSGs, contribute to aspects of metastasis, and may stand as novel therapeutic targets...
  100. doi Generation of MCF-7 cells with aggressive metastatic potential in vitro and in vivo
    Elke Ziegler
    Department of Gynecology and Obstetrics, Georg August University, Robert Koch Street 40, 37075, Gottingen, Germany
    Breast Cancer Res Treat 148:269-77. 2014
    ..Protein expression of epithelial marker CDH1 was clearly decreased. With the breast cancer cell lines, MCF-7-EMT and MCF-7 WT cells, we have an excellent model of cells for further studies of EMT and invasion in vitro and in vivo. ..
  101. doi N-cadherin mediates the migration of MCF-10A cells undergoing bone morphogenetic protein 4-mediated epithelial mesenchymal transition
    Ki Sook Park
    East West Medical Research Institute College of Medicine, Kyung Hee University, Seoul, 130 701, Korea
    Tumour Biol 36:3549-56. 2015
    ..Thus, active canonical BMP4 signaling is important for the migration and EMT of mammary epithelial cells. Moreover, the decrease in E-cadherin and/or increase in N-cadherin may be required for BMP4-induced migration and EMT. ..

Research Grants16

  1. Mechanisms of N-Cadherin Mediated Breast CA Metastasis
    Rachel Hazan; Fiscal Year: 2005
    ..abstract_text> ..
  2. Cadherin Mediated Cell-Cell Interactions in the Bone Microenvironment
    Roberto Civitelli; Fiscal Year: 2013
    ..members of the cadherin superfamily of cell adhesion molecules, in particular cadherin-11 (Cad11) and N-cadherin (Ncad)...
  3. Signals Regulating SAG Development
    James A Marrs; Fiscal Year: 2010
    ..We propose a novel approach to the study of this process, which fits NIDCD Program Announcement PA-07-127. ..
  4. An investigation of guidance mechanisms regulating neuronal migration
    Sarah J Wanner; Fiscal Year: 2013
    ..Preliminary experiments have shown that N-cadherin (Ncad), a prominent cell adhesion molecule in the nervous system, is required for facial branchiomotor neuron (FBMN) ..
  5. Mechanism of differential adhesion by protocadherin-cadherin complexes
    JAMES DAVID JONTES; Fiscal Year: 2013
    ..In our previous work, we showed that Protocadherin-19 (Pcdh19) associates with N-cadherin (Ncad) to form a heteromeric cis-complex...
  6. Axon-glial interactions mediating axonal regeneration
    Toby A Ferguson; Fiscal Year: 2013
    ..Neuronal cadherin (NCAD), a homophilic cell adhesion molecule expressed by both axons and Schwann cells is an attractive candidate to ..
  7. SWI/SNF & Yolk Sac Development
    Terry Magnuson; Fiscal Year: 2010
    ..Misregulation of these pathways are known to regulate proliferation, migration, differentiation and apoptosis, all of which are key steps in yolk sac development. ..
  8. CADHERIN REGULATION OF OSTEOBLAST FUNCTION
    Roberto Civitelli; Fiscal Year: 2004
    ..members of the cadherin superfamily of cell adhesion molecules, in particular cadherin-11 (cadl1) and N-cadherin (Ncad)...
  9. DEVELOPMENT OF MULTIFUNCTIONAL CONTRAST AGENTS
    Lajos Balogh; Fiscal Year: 2006
    ..Each NCAD will have a specific size (5, 10 and 25 nm), a specific surface (well-defined positive or negative net surface ..
  10. BRAINS RULE! NEUROSCIENCE EXPOSITIONS
    Andrea Zardetto Smith; Fiscal Year: 2004
    ..WIN, AOTA, APTA-Neurology Section, AANN, the Foundation for Biomedical Research, the NCAD, the NIMH Office of Neuroinformatics, Boys and Girls Club of America, the American Indian Science and Engineering ..
  11. Cell Interactions in Synapes Formation and Function
    Juan Bruses; Fiscal Year: 2005
    ....
  12. RAS MEDIATED, ANCHORAGE INDEPENDENT GROWTH
    ROBERT KRAUSS; Fiscal Year: 2002
    ..Such genes represent potential mediators of the transformed phenotype. ..
  13. Mice That Lack CDO: A Model for Mild Holoprosencephaly
    ROBERT KRAUSS; Fiscal Year: 2004
    ....
  14. Role of CD164 in Skeletal Myogenesis
    ROBERT KRAUSS; Fiscal Year: 2008
    ..This research should therefore shed light on fundamental processes by which skeletal muscles develop. [unreadable] [unreadable]..
  15. Gene-Environment Interaction in Holoprosencephaly: Role of Fetal Alcohol Exposure
    ROBERT KRAUSS; Fiscal Year: 2008
    ..Such information may have important public health impact and could ultimately aid in the counseling of HPE mutation carriers. [unreadable] [unreadable] [unreadable]..
  16. Role of Plakophilin-1 in HNSCC
    James Wahl; Fiscal Year: 2009
    ..Defining the nuclear function of plakophilin-1 will lay the ground work for identifying new prognostic markers for HNSCC and also potential targets for novel therapeutic strategies for treating the disease. ..