Genomes and Genes
Gene Symbol: N-cadherin
Description: cadherin 2
Alias: CD325, CDHN, CDw325, NCAD, cadherin-2, N-cadherin 1, cadherin 2, type 1, N-cadherin (neuronal), calcium-dependent adhesion protein, neuronal, neural cadherin
Publications227 found, 100 shown here
- Identification of mammalian and invertebrate analogues of the avian calcium-dependent cell adhesion protein N-cadherin with synthetic-peptide directed antibodies against a conserved cytoplasmic domainL A Lagunowich
Department of Anatomy, Thomas Jefferson University, Philadelphia, PA 19107
Biochem Biophys Res Commun 172:313-20. 1990..We produced a monospecific polyclonal antiserum, C-NCAD(838-856), to a synthetic peptide corresponding to a portion of the highly conserved c-terminal cytoplasmic domain ..
- Isolation and characterization of the promoter region of the chicken N-cadherin geneB Li
Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, OH 45267 0521, USA
Gene 191:7-13. 1997....
- N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membraneJames K Wahl
University of Nebraska Medical Center, College of Dentistry and Eppley Cancer Center, Omaha, Nebraska 68198 7696, USA
J Biol Chem 278:17269-76. 2003..These data suggest that a core N-cadherin-catenin complex assembles in the endoplasmic reticulum or Golgi compartment and is transported to the plasma membrane where linkage to the actin cytoskeleton can be established...
- Drosophila N-cadherin functions in the first stage of the two-stage layer-selection process of R7 photoreceptor afferentsChun Yuan Ting
Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Development 132:953-63. 2005..N-cadherin is required in the first stage for R7 growth cones to reach and remain in the R7-temporary layer. The Ncad gene contains three pairs of alternatively spliced exons and encodes 12 isoforms...
- Traction forces exerted through N-cadherin contactsArthur Ganz
INSERM, U706, Paris, F 75005 France
Biol Cell 98:721-30. 2006..The present study focuses on the determination of force transduction through cadherins at a single cell level...
- Calsenilin regulates presenilin 1/γ-secretase-mediated N-cadherin ε-cleavage and β-catenin signalingChanghwan Jang
Ilsong Institute of Life Science, Hallym University, 1605 4 Gwanyang dong, Dongan Gu, Anyang, Gyeonggi do 431 060, Republic of Korea
FASEB J 25:4174-83. 2011..cleavage of N-cadherin, which results in the significant accumulation of N-cadherin C-terminal fragment 1 (Ncad/CTF1), the reduction of cytoplasmic Ncad/CTF2 release, and a deceleration of PS1-CTF delivery to the cell surface...
- N-cadherin mediates angiogenesis by regulating monocyte chemoattractant protein-1 expression via PI3K/Akt signaling in prostate cancer cellsArun Kumar Nalla
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, IL, USA
Exp Cell Res 317:2512-21. 2011..Our data demonstrated that N-cadherin in prostate cancer cell mediates cell-cell adhesion and regulates MCP-1 expression via the PI3K/Akt signaling pathway...
- IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coliManisha Sharma
Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales 2145, Australia
J Biol Chem 282:8545-56. 2007....
- GSK3beta activity modifies the localization and function of presenilin 1Kengo Uemura
Horizontal Medical Research Organization, Kyoto University Graduate School of Medicine, Kyoto, Japan
J Biol Chem 282:15823-32. 2007....
- Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1Yasushi Shintani
Department of Oral Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
J Cell Biol 180:1277-89. 2008..Both receptor complexes rely on the p130 Crk-associated substrate scaffold. Interestingly, Rap1, but not Rho family guanosine triphosphatases, is required for the response to collagen I...
- The green tea compound, (-)-epigallocatechin-3-gallate downregulates N-cadherin and suppresses migration of bladder carcinoma cellsKimberly M Rieger-Christ
Cell and Molecular Biology Laboratory, Robert E Wise Research and Education Institute, Lahey Clinic Medical Center, 31 Mall Road, Burlington, Massachusetts 01805, USA
J Cell Biochem 102:377-88. 2007..Continuous administration of EGCG to mice revealed significant inhibition of tumor growth in vivo indicating a possible preventative role for green tea in bladder cancer...
- Cadherins are regulated by Ep-CAM via phosphaditylinositol-3 kinaseManon J Winter
Department of Pathology, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
Mol Cell Biochem 302:19-26. 2007..The Pi3K activity shuttled from N-cadherin to Ep-CAM. From our results, we conclude that Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells...
- Extrajunctional distribution of N-cadherin in cultured human endothelial cellsD Salomon
Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
J Cell Sci 102:7-17. 1992..Comparison of this pattern with the discrete junctional labeling obtained with the pan-cadherin antibody suggests that different cadherins, co-expressed in the same endothelial cells, may undergo differential surface distribution...
- Human N-cadherin: nucleotide and deduced amino acid sequenceR A Reid
Becton Dickinson and Company Research Center, Research Triangle Park, NC 27709
Nucleic Acids Res 18:5896. 1990
- Functional cis-heterodimers of N- and R-cadherinsW S Shan
Department of Biochemistry and Molecular Biology, Program in Cell Adhesion, The Mount Sinai School of Medicine, New York University, New York 10029, USA
J Cell Biol 148:579-90. 2000..The present study provides a novel paradigm for cadherin interaction whereby selective cis-heterodimer formation may generate new functional units to mediate cell-cell adhesion...
- A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptorKimita Suyama
Derald H Ruttenberg Cancer Center, The Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Cancer Cell 2:301-14. 2002..These results suggest that protection of the FGFR-1 from ligand-induced downregulation by N-cadherin enhances receptor signaling and provides a mechanism by which tumor cells can acquire metastatic properties...
- Cadherin switch in tumor progressionRachel B Hazan
Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Ann N Y Acad Sci 1014:155-63. 2004..Here, we summarize the various aspects of the E- to N-cadherin switching in epithelial carcinomas and its potential impact on metastatic progression...
- Neoexpression of N-cadherin in E-cadherin positive colon cancersErika Rosivatz
Institut für Pathologie der TU, Munchen, Germany
Int J Cancer 111:711-9. 2004....
- Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesionHajime Yano
Department of Molecular Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
J Cell Biol 166:283-95. 2004..Our analyses simultaneously exemplified the essential role of Fak in the maintenance of cell-cell adhesions in collective cell migration, a type of migration occurring in embryonic development and carcinoma invasion...
- Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-beta or woundingOlivier De Wever
Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium
J Cell Sci 117:4691-703. 2004..Taken together, our study identifies a new mechanism in which cancer cells contribute to the coordination of invasion of stromal myofibroblasts...
- Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transitionMasato Maeda
Department of Oral Biology College of Dentistry, University of Nebraska Medical Center, Omaha, NE 68198 7696, USA
J Cell Sci 118:873-87. 2005..Together, these data suggest that cadherin switching is necessary for increased motility but is not required for the morphological changes that accompany EMT...
- Gingipains from Porphyromonas gingivalis W83 induce cell adhesion molecule cleavage and apoptosis in endothelial cellsShaun M Sheets
Department of Biochemistry and Microbiology, School of Medicine, Loma Linda University, Loma Linda, CA 92350, USA
Infect Immun 73:1543-52. 2005..Taken together, these results indicate that gingipains from P. gingivalis can alter cell adhesion molecules and induce endothelial cell death, which could have implications for the pathogenicity of this organism...
- N-cadherin-dependent cell-cell contacts promote human saphenous vein smooth muscle cell survivalEvgenia Koutsouki
Bristol Heart Institute, Bristol Royal Infirmary, Bristol, UK
Arterioscler Thromb Vasc Biol 25:982-8. 2005..Vascular smooth muscle cell (VSMC) apoptosis is thought to contribute to atherosclerotic plaque instability. Cadherin mediates calcium-dependent homophilic cell-cell contact. We studied the role of N-cadherin in VSMC apoptosis...
- Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesionKeiran S M Smalley
Wistar Institute, 3601 Spruce St, Philadelphia, Pennsylvania 19104, USA
Am J Pathol 166:1541-54. 2005....
- Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the beta-catenin signaling pathwayJianfei Qi
Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada
Mol Biol Cell 16:4386-97. 2005..Transendothelial migration was compromised in cells expressing a dominant-negative form of beta-catenin, thus supporting a regulatory role of beta-catenin signaling in this process...
- N-cadherin expression in breast cancer: correlation with an aggressive histologic variant--invasive micropapillary carcinomaChandandeep Nagi
Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA
Breast Cancer Res Treat 94:225-35. 2005..005), whereas such changes were not significant in the non-MPAP group (p = 0.10). Thus, N-cadherin is associated with tumor aggressiveness and metastatic potential and may contribute to tumor progression...
- N-cadherin as a novel prognostic marker of progression in superficial urothelial tumorsIsabelle Lascombe
Tissue and Cell Biology Engineering, Besancon, France
Clin Cancer Res 12:2780-7. 2006..The purpose of this study was to investigate whether N-cadherin expression was associated with the bladder tumor progression...
- Up-regulation of gastric cancer cell invasion by Twist is accompanied by N-cadherin and fibronectin expressionZhou Yang
Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China
Biochem Biophys Res Commun 358:925-30. 2007..Taken together, our results suggest that Twist regulates cell motility and invasion in gastric cancer cell lines, probably through the N-cadherin and fibronectin production...
- Differential expression of neural-cadherin in pulmonary epithelial tumoursD L Zynger
Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
Histopathology 52:348-54. 2008..The aim was to determine whether evaluation of N-cadherin in pulmonary tumours might assist in identifying lesions with more aggressive potential...
- Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell linesHerve Wallerand
Department of Urology, CHU Pellegrin, Victor Segalen School of Medicine, Bordeaux, France
Urol Oncol 28:180-8. 2010....
- The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brainHelena Grinberg-Rashi
Cancer Research Center and Pathology Department, Sheba Medical Center, Ramat Gan, Israel
Clin Cancer Res 15:1755-61. 2009..We hypothesized that the expression of genes in primary NSCLC tumors could predict brain metastasis and be used for identification of high-risk patients, who may benefit from prophylactic therapy...
- N-cadherin knock-down decreases invasiveness of esophageal squamous cell carcinoma in vitroKe Li
Department of Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China
World J Gastroenterol 15:697-704. 2009....
- Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistanceHiroshi Tanaka
Department of Urology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
Nat Med 16:1414-20. 2010..These data indicate that N-cadherin is a major cause of both prostate cancer metastasis and castration resistance. Therapeutic targeting of this factor with monoclonal antibodies may have considerable clinical benefit...
- Epithelial N-cadherin and nuclear β-catenin are up-regulated during early development of human lungRiitta Kaarteenaho
Institute of Clinical Medicine, Department of Internal Medicine Respiratory Research Unit, Centre of Excellence in Research, University of Oulu and Oulu University Hospital, Oulu, Finland
BMC Dev Biol 10:113. 2010..The aim of this study was to analyze the cell-specific expression of E- and N-cadherin and β-catenin in developing human lung tissues from 12 to 40 weeks of gestation...
- Inverse association between miR-194 expression and tumor invasion in gastric cancerYongxi Song
Department of Surgical Oncology and General Surgery, First Hospital of China Medical University, Shenyang, People s Republic of China
Ann Surg Oncol 19:S509-17. 2012..MiR-194 has been shown to be specifically expressed in the human gastrointestinal tract and may play an antimetastatic role in primary liver cancer cells. However, the role of miR-194 in gastric cancer is still unclear...
- Twist modulates human trophoblastic cell invasion via regulation of N-cadherinYork Hunt Ng
Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V5
Endocrinology 153:925-36. 2012..Similarly, a reduction in N-cadherin decreased the invasive capacity of HTR-8/SVneo cells. Twist is an upstream regulator of N-cadherin-mediated invasion of human trophoblastic cells...
- Positive expression of LSD1 and negative expression of E-cadherin correlate with metastasis and poor prognosis of colon cancerDing Jie
Department of Gastrointestinal Surgery, Guizhou Provincial People s Hospital, Guiyang, 550002, Guizhou Province, China
Dig Dis Sci 58:1581-9. 2013..The first identified lysine-specific demethylase, LSD1, plays an important role in the metastatic progression of several types of cancer...
- Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expressionYasushi Shintani
Department of Oral Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
Cancer Res 66:11745-53. 2006..We show that JNK1 is activated in response to collagen I, which increases tumorigenesis by up-regulating N-cadherin expression and by increasing motility...
- Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherinStephen N Hartland
MRC University of Edinburgh Centre for Inflammation Research, Edinburgh, UK
Liver Int 29:966-78. 2009..This is accompanied by HSC apoptosis. In this study, we examine a potential mechanism whereby MMP activity might induce HSC apoptosis by cleaving N-cadherin at the cell surface...
- Epstein-Barr virus latent membrane protein-1 effects on junctional plakoglobin and induction of a cadherin switchKathy H Y Shair
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Cancer Res 69:5734-42. 2009..Low levels of plakoglobin were also detected in human NPC tissues. These findings reveal that the effects of LMP1 on junctional plakoglobin and the initiation of a cadherin switch likely contribute to metastasis of NPC...
- Signal transduction from N-cadherin increases Bcl-2. Regulation of the phosphatidylinositol 3-kinase/Akt pathway by homophilic adhesion and actin cytoskeletal organizationNhan L Tran
Cancer Biology Graduate Program, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
J Biol Chem 277:32905-14. 2002..We propose that N-cadherin homophilic adhesion can initiate anti-apoptotic signaling, which enhances the Akt cell survival pathway in metastatic cancer...
- Expression analysis of epithelial cadherin and related proteins in IBH-6 and IBH-4 human breast cancer cell linesLara Lapyckyj
Instituto de Biologia y Medicina Experimental, National Research Council of Argentina CONICET, C1428ADN Buenos Aires, Argentina
J Cell Physiol 222:596-605. 2010..Several molecules associated with down-regulation of E-cadherin have been described, within them neural cadherin, Twist and dysadherin...
- Neural-cadherin expression associated with angiogenesis in non-small-cell lung cancer patientsT Nakashima
Second Department of Surgery, Kagawa Medical University, 1750 1 Miki cho, Kita gun, Japan
Br J Cancer 88:1727-33. 2003..Thus, N-cadherin also might play a specific role in undifferentiated large cell carcinomas...
- Neural cadherin is expressed in human gametes and participates in sperm-oocyte interaction eventsC I Marín-Briggiler
Instituto de Biologia y Medicina Experimental, National Research Council of Argentina CONICET, University of Buenos Aires, Buenos Aires, Argentina
Int J Androl 33:e228-39. 2010b>Neural cadherin (N-cadherin) is a transmembrane glycoprotein involved in calcium-dependent cell-cell adhesion and signalling events...
- Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface NMDA receptorK Uemura
Horizontal Medical Research Organization, Kyoto University Graduate School of Medicine, Kyoto, Japan 606 8507
Neuroscience 145:5-10. 2007..cleaved by ADAM10 and PS1/gamma-secretase, producing a cytoplasmic fragment, N-cadherin C-terminal fragment (Ncad/CTF2) after NMDA receptor stimulation [Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, Siman R, Robakis NK (2003)..
- Structural basis of calcium-induced E-cadherin rigidification and dimerizationB Nagar
Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
Nature 380:360-4. 1996..aligned in a parallel orientation, the interactions between them differ significantly from those found in the neural cadherin (N-cadherin) N-terminal domain (NCD1) structure...
- Epithelial-type and neural-type cadherin expression in malignant noncarcinomatous neoplasms with epithelioid features that involve the soft tissuesWilliam B Laskin
Department of Pathology, Northwestern University Medical School, Chicago, IL 60611 3053, USA
Arch Pathol Lab Med 126:425-31. 2002Transmembrane adhesion molecules, epithelial-type cadherin (ECAD) and neural-type cadherin (NCAD), help in regulating transformations between epithelial and mesenchymal cells in the developing embryo and in maintaining the epithelioid ..
- Cranial sensory ganglia neurons require intrinsic N-cadherin function for guidance of afferent fibers to their final targetsA Lamora
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
Neuroscience 159:1175-84. 2009..Together, our in vivo data reveal a novel role for cdh2 in the establishment of circuits by peripheral sensory neurons...
- The association of elasticity indexes of ascending aorta and the presence and the severity of coronary artery diseaseAli Yildiz
Department of Cardiology, School of Medicine, Harran University, Sanliurfa, Turkey
Coron Artery Dis 19:311-7. 2008..To investigate the association between elasticity indexes of aorta and severity of coronary artery disease (CAD) in patients with stable CAD...
- Retinal patterning by Pax6-dependent cell adhesion moleculesElisabeth Rungger-Brandle
Cell Biology Laboratory, University Eye Clinic, HUG, Rue Alcide Jentzer, Geneva, Switzerland
Dev Neurobiol 70:764-80. 2010..by morpholino antisense molecules in Xenopus embryos and knockdown of maternal N-cadherin (mNcad), N-cadherin (Ncad) and neural cell adhesion molecule (NCAM) produce similar phenotypes...
- Butyrylcholinesterase K variants increase the risk of coronary artery disease in the population of western IranA Vaisi-Raygani
Department of Clinical Biochemistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
Scand J Clin Lab Invest 68:123-9. 2008..They were matched and randomly assigned into four groups: CAD+T2DM+ (CAD/T2DM), CAD+DM(-) (CAD/ND), CAD(-)DM+ (T2DM/NCAD) and CAD(-)DM(-)(control). The BCHE-K variant was detected by PCR-RFLP...
- Differential function of N-cadherin and cadherin-7 in the control of embryonic cell motilityS Dufour
UMR 144, Compartimentation et Dynamique Cellulaires, Centre National de la Recherche Scientifique et Institut Curie, 75248 Paris Cedex 05, France
J Cell Biol 146:501-16. 1999..the prototypes of type I and type II cadherin, induced cell-cell adhesion in murine sarcoma 180 transfectants, Ncad-1 and cad7-29, respectively...
- Comparative expression patterns of T-, N-, E-cadherins, beta-catenin, and polysialic acid neural cell adhesion molecule in rat cochlea during development: implications for the nature of Kölliker's organLionel Simonneau
Laboratoire de Neurobiologie de l Audition Plasticité Synaptique, Institut National de la Santé et de la Recherche Médicale U254, Universite Montpellier I, 34090 Montpellier, France
J Comp Neurol 459:113-26. 2003..CAMs) during rat cochlea ontogeny, from embryo day 16 to adulthood, with the use of immunohistochemistry: neural cadherin (N-cad) and polysialic acid neural CAM (PSA-NCAM) as two different neural CAM paradigms; epithelial cadherin (..
- Assessing the role of claudins in maintaining the integrity of epididymal tight junctions using novel human epididymal cell linesEvemie Dube
INRS Institut Armand Frappier, University of Quebec, 531 Boulevard des Prairies, Laval, Quebec, Canada
Biol Reprod 82:1119-28. 2010..Disruption of CLDN1, CLDN3, CLDN4, and CLDN7 could, therefore, lead to epididymal dysfunction, resulting in male infertility...
- Mutations in N-cadherin and a Stardust homolog, Nagie oko, affect cell-cycle exit in zebrafish retinaMasahiro Yamaguchi
Developmental Neurobiology Unit, Okinawa Institute of Science and Technology OIST, Azatancha 1919 1, Onna, Okinawa 904 0412, Japan
Mech Dev 127:247-64. 2010..progenitor cells to the total number of retinal cells increases in the neurogenic stages in zebrafish n-cadherin (ncad) and nagie oko (nok) mutants, in which the apicobasal cell polarity and adherens junctions in the retinal ..
- Expression of adrenomedullin in human epicardial adipose tissue: role of coronary statusAlina Silaghi
INSERM U626, Aix Marseille Universite, Marseille Cedex 5, France
Am J Physiol Endocrinol Metab 293:E1443-50. 2007..of subcutaneous WAT (sWAT) and eWAT obtained from patients with coronary artery disease (CAD) or without CAD (NCAD)...
- Tubulobulbar complexes are intercellular podosome-like structures that internalize intact intercellular junctions during epithelial remodeling events in the rat testisJ Nelle S Young
Department of Cellular and Physiological Sciences, Faculty of Medicine, Life Sciences Centre, The University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
Biol Reprod 80:162-74. 2009..Our results are consistent with the conclusion that tubulobulbar complexes are podosome-like structures that are responsible for internalizing intact intercellular junctions during spermatogenesis...
- Identification of novel androgen response genes in prostate cancer cells by coupling chromatin immunoprecipitation and genomic microarray analysisK Takayama
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Oncogene 26:4453-63. 2007..The present study would be powerful to extend our knowledge of the diversity of androgen genetic network and steroid action in prostate cancer cells...
- Seven genes from human chromosome 18 map to chromosome 24 in the bovineN J Larsen
Department of Animal Sciences, University of Wisconsin, Madison 53706, USA
Cytogenet Cell Genet 73:184-6. 1996..These STSs were used for synteny mapping, and all seven genes were syntenic with markers of bovine chromosome (BTA) 24. The concordance with BTA 24 was at least 96.5% for all genes...
- Substrate-dependent regulation of carbon catabolism in marine sulfate-reducing Desulfobacterium autotrophicum HRM2Judith Amann
Max Planck Institute for Marine Microbiology, Bremen, Germany
J Mol Microbiol Biotechnol 18:74-84. 2010..In summary, the different regulatory patterns displayed by Db. autotrophicum HRM2 at the tested metabolic levels point to a multi-layered regulatory network...
- Paraoxonase and arylesterase activities in coronary artery diseaseM Gur
Harran University, Sanliurfa, Turkey
Eur J Clin Invest 36:779-87. 2006..Accordingly, the aim of the study was to investigate the paraoxonase, arylesterase activities and oxidative/anti-oxidative status in coronary artery disease (CAD) and their correlation with the extent of CAD...
- Plasma HDL-cholesterol has an effect on nitric oxide production and arachidonic acid metabolism in the platelet membranes of coronary heart disease patients without LDL-hypercholesterolemiaP Tretjakovs
Latvian Institute of Experimental and Clinical Medicine, Riga, Latvia
Med Sci Monit 6:507-11. 2000..To evaluate nitric oxide (NO) production and [3H]arachidonic acid (AA) incorporation into platelet membranes of coronary artery disease (CAD) patients with/without HDL-hypocholesterolemia...
- Global comparative transcriptome analysis of cartilage formation in vivoTrevor L Cameron
Murdoch Childrens Research Institute and Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Parkville, Victoria 3052, Australia
BMC Dev Biol 9:20. 2009..Regulation of the onset of chondrogenesis is incompletely understood, and would be informed by comprehensive analyses of in vivo gene expression...
- MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortexJill M Weimer
UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Development 136:2965-75. 2009....
- Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypesBen M Minogue
Tissue Injury and Repair, School of Biomedicine, Faculty of Medical and Human Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
Arthritis Res Ther 12:R22. 2010....
- Integrated proteomics and genomics analysis reveals a novel mesenchymal to epithelial reverting transition in leiomyosarcoma through regulation of slugJilong Yang
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Mol Cell Proteomics 9:2405-13. 2010..An increase in Slug expression by pCMV6-XL5-Slug transfection decreased E-cadherin and increased vimentin and N-cadherin. Thus, MErT, which is mediated through regulation of Slug, is a clinically significant phenotype in leiomyosarcoma...
- Cell-cell adhesion in the prelaminar region of the optic nerve head: a possible target for ionic stressFrancisco Javier Carreras
Department of Surgery Ophthalmology, Faculty of Medicine, University of Granada, ES 18071 Granada, Spain
Ophthalmic Res 42:106-11. 2009..The intercellular junctions of the lining astrocytes mediated by cellular adhesion molecules (CAMs) may be the main targets for ionic stress...
- Regeneration in the adult mammalian CNS: guided by developmentI Aubert
Laboratory of Genetics, Salk Institute, La Jolla, California 92037 1099, USA
Curr Opin Neurobiol 5:625-35. 1995..neurotrophic growth factor), growth cone guidance (netrins and semaphorins), axonal outgrowth and sorting (neural cadherin, polysialylated neural cell adhesion molecules, and L1), and neuronal connectivity (cell adhesion molecules, ..
- Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancersH Ohta
Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
Br J Cancer 100:389-98. 2009..Our proposed extensive Hh-EMT signal pathway has the potential to an understanding of diffuse-type GC and to the development of new drugs...
- Multiple metastases from cutaneous malignant melanoma patients may display heterogeneous genomic and epigenomic patternsKatja Harbst
Department of Oncology, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
Melanoma Res 20:381-91. 2010..These data are further corroborated by a switch in CDH1 and CDH2 expression between metastases from the same patient. In conclusion, our results provide evidence for different models of metastatic progression in melanoma...
- parachute/n-cadherin is required for morphogenesis and maintained integrity of the zebrafish neural tubeZsolt Lele
Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
Development 129:3281-94. 2002N-cadherin (Ncad) is a classical cadherin that is implicated in several aspects of vertebrate embryonic development, including somitogenesis, heart morphogenesis, neural tube formation and establishment of left-right asymmetry...
- Cadherin-2 participates in the morphogenesis of the zebrafish inner earSherry Babb-Clendenon
Department of Medicine, Indiana University Medical Center, 950 West Walnut Street, Indianapolis, IN 46202, USA
J Cell Sci 119:5169-77. 2006..These findings demonstrate that Cdh2 selectively affects epithelial morphogenetic cell movements, particularly semicircular canal formation, during normal ear mophogenesis...
- Non-cardiac arterial disease in Catalonia: patient profiles and quality of clinical records by characteristics of the Vascular Surgery UnitM A Cairols Castellote
Catalan Society of Angiology and Vascular Surgery, Barcelona, Spain
Int Angiol 27:124-34. 2008Non-cardiac arterial disease (NCAD) is a frequent cause of hospital admission. The aim of this study was to investigate differences in patient profiles and clinical records as a function of the size of the Vascular Surgery Unit (VSU).
- N-cadherin mediates plasticity-induced long-term spine stabilizationPablo Mendez
Department of Neuroscience, University of Geneva, Faculty of Medicine, Geneva, Switzerland
J Cell Biol 189:589-600. 2010..this study, we combined repetitive imaging and a gain and loss of function approach to test the role of N-cadherin (NCad) on spine stability...
- Surface expression of precursor N-cadherin promotes tumor cell invasionDeborah Maret
Brain Tumour Research Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Neoplasia 12:1066-80. 2010The expression of N-cadherin (NCAD) has been shown to correlate with increased tumor cell motility and metastasis...
- Ventral neural cadherin, a novel cadherin expressed in a subset of neural tissues in the zebrafish embryoJ I Franklin
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2790, USA
Dev Dyn 206:121-30. 1996..Here we describe a novel member of this gene family, zebrafish ventral neural cadherin (VN-cad). Multiple VN-cad transcripts are first detectable by Northern blots at 60% epiboly...
- Up-regulation of cadherin-2 and cadherin-4 in regenerating visual structures of adult zebrafishQ Liu
Department of Biology, University of Akron, Akron, Ohio 44325 3908, USA
Exp Neurol 177:396-406. 2002..Our results suggest that both Cdh2 and Cdh4 may be important for regeneration of injured retinal ganglion cell axons...
- Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structureIgor Kostetskii
Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Circ Res 96:346-54. 2005....
- Ovo1 links Wnt signaling with N-cadherin localization during neural crest migrationSarah Piloto
Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
Development 137:1981-90. 2010..target gene that controls migration of pigment precursors by regulating the intracellular movements of N-cadherin (Ncad). Ovo1 genetically interacts with Ncad and its depletion causes Ncad to accumulate inside cells...
- N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin geneF S Walsh
Department of Experimental Pathology, UMDS, Guy s Hospital, London, England
J Neurochem 55:805-12. 1990..This is distinct from the E-cadherin locus on chromosome 16. Therefore, it is likely that the cadherins have evolved from a common precursor gene that has undergone duplication and migration to other chromosomal locations...
- Isolation and developmental expression of retinoic-acid-induced genesL J Jonk
Hubrecht Laboratorium, Netherlands Institute for Developmental Biology, Utrecht
Dev Biol 161:604-14. 1994..In addition to the previously recognized genes encoding vimentin, heat stable antigen, neural cadherin, Hox-B2, F52/MacMARCKS, thymosin beta 4b, and the murine homolog of COUP-TF1, we identified 7 novel genes, 5 ..
- Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: an in vitro and in vivo studyNikki P Y Lee
Population Council, New York, New York 10021, USA
Biol Reprod 73:458-71. 2005..These results illustrate that the CDH2/CATNB-mediated adhesion function in the testis is regulated, at least in part, via the NOS/cGMP/PRKG/CATNB pathway...
- Accentuated ovariectomy-induced bone loss and altered osteogenesis in heterozygous N-cadherin null miceChung Fang Lai
Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington School of Medicine, St Louis, Missouri 63110, USA
J Bone Miner Res 21:1897-906. 2006....
- Cadherin expression in the developing mouse olfactory systemMichael R Akins
Interdepartmental Neuroscience Graduate Program, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
J Comp Neurol 501:483-97. 2007..We conclude that cadherin proteins in the developing olfactory system are positioned to underlie the formation of the odorant map and local circuits within the OB...
- Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signalingMichael B Major
Howard Hughes Medical Institute, University of Washington School of Medicine, Box 357370, Seattle, WA 98195, USA
Science 316:1043-6. 2007..These data provide a possible mechanistic explanation for the tumor suppressor activity of WTX...
- The prognostic value of cadherin switch in bladder cancerTobias Jager
Department of Urology, University of Duisburg Essen, 45147 Essen, Germany
Oncol Rep 23:1125-32. 2010..The poor patient prognosis in N-cadherin-negative muscle-invasive tumors indicates an alternative, N-cadherin-independent way in bladder cancer progression...
- The cleavage of N-cadherin is essential for chondrocyte differentiationShigeto Nakazora
Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu City, Mie 514 8507, Japan
Biochem Biophys Res Commun 400:493-9. 2010..These results suggested that the cleavage of N-cadherin is essential for chondrocyte differentiation...
- Smad7 restricts melanoma invasion by restoring N-cadherin expression and establishing heterotypic cell-cell interactions in vivoKyle A Divito
Department of Biochemistry and Molecular Biology, Georgetown University School of Medicine Washington, DC, USA
Pigment Cell Melanoma Res 23:795-808. 2010..We propose that Smad7 suppresses β-catenin degradation and promotes interaction with N-cadherin, stabilizing association with neighboring dermal fibroblasts, thus mitigating invasion...
- N-cadherin and β1-integrins cooperate during the development of the enteric nervous systemFlorence Broders-Bondon
Institut Curie CNRS UMR144, Paris, France
Dev Biol 364:178-91. 2012..N-cadherin-null (Ncad-/-) ENCC exhibited a delayed colonization in the developing gut at E12...
- Clinical implications of N-cadherin expression in gastric cancerTakahito Kamikihara
Digestive Surgery, Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan
Pathol Int 62:161-6. 2012..However, neo N-cadherin expression significantly affected patient's survival in gastric cancer. Therefore, we concluded that neo N-cadherin expression may be a useful prognostic marker independent of E-cadherin expression...
- Protein kinase casein kinase 2-mediated upregulation of N-cadherin confers anoikis resistance on esophageal carcinoma cellsHyeonseok Ko
Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, 50 Yonsei ro, Seodaemun gu, Seoul, Korea
Mol Cancer Res 10:1032-8. 2012..We conclude that high intracellular PKCK2 activity confers anoikis resistance on esophageal cancer cells by inducing E- to N-cadherin switching...
- GSK3β inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylationJobin K John
Department of Molecular Oncology, The Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
J Invest Dermatol 132:2818-27. 2012..These studies suggest the potential therapeutic utility of inhibiting GSK3β in defined subsets of melanoma...
- Distinct mesenchymal alterations in N-cadherin and E-cadherin positive primary renal epithelial cellsChristof Keller
Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
PLoS ONE 7:e43584. 2012..Renal tubular epithelial cells of proximal and distal origin differ markedly in their physiological functions. Therefore, we hypothesized that they also differ in their capacity to undergo epithelial to mesenchymal alterations...
- N-cadherin sustains motility and polarity of future cortical interneurons during tangential migrationCamilla Luccardini
Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 839, Institut du Fer a Moulin, 75005 Paris, France, Universite Pierre et Marie Curie Paris 6, 75005 Paris, France, Graduate School of Frontier Biosciences, Osaka University, Osaka 565 0871, Japan, Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London, London, WC1E 6BT, United Kingdom, and Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892
J Neurosci 33:18149-60. 2013..Altogether, these results identify N-cadherin as a pivotal adhesion substrate that activates cell motility in future cortical interneurons and maintains cell polarity over their long-distance migration to the developing cortex. ..
- Role of endothelial cell septin 7 in the endocytosis of Candida albicansQuynh T Phan
Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California, USA
MBio 4:e00542-13. 2013..albicans infection, SEPT7 forms a complex with endothelial cell N-cadherin, is required for normal accumulation of N-cadherin around C. albicans hyphae, and is necessary for maximal endocytosis of the organism...
- A ROS/STAT3/HIF-1α signaling cascade mediates EGF-induced TWIST1 expression and prostate cancer cell invasionKyung Hwa Cho
Department of Pharmacology, Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon, Republic of Korea
Prostate 74:528-36. 2014..The purpose of this study is to determine the underlying mechanism of EGF-induced TWIST1 expression and prostate cancer invasion...
- Restricted expression of classic cadherins in the spinal cord of the chicken embryoJuntang Lin
Institute of Anatomy I, University of Jena School of Medicine Jena University Hospital Jena, Germany Xinxiang Medical University Xinxiang, Henan, China
Front Neuroanat 8:18. 2014..The highly regulated spatiotemporal expression patterns of the classic cadherins indicate that these genes potentially play multiple and diverse roles during the development of the SP and its surrounding tissues. ..
- Strong correlation between N-cadherin and CD133 in breast cancer: role of both markers in metastatic eventsCarolin Bock
Department of Obstetrics and Gynaecology, Campus Innenstadt, Ludwig Maximilians University Hospital, Maistraße 11, 80337, Munich, Germany
J Cancer Res Clin Oncol 140:1873-81. 2014..Our main goal was to investigate the role of the EMT marker, N-cadherin, and of the stem cell marker, CD133, in breast cancer...
- Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell linesNatascia Marino
Women s Malignancies Branch, Center for Cancer Research, National Cancer Institute, Building 37 Room 1126, 37 Convent Drive, Bethesda, MD, 20892, USA
Clin Exp Metastasis 31:771-86. 2014..045 and p = 0.009 respectively). This study demonstrates that previously unrecognized genes are inversely related to the expression of multiple MSGs, contribute to aspects of metastasis, and may stand as novel therapeutic targets...
- Generation of MCF-7 cells with aggressive metastatic potential in vitro and in vivoElke Ziegler
Department of Gynecology and Obstetrics, Georg August University, Robert Koch Street 40, 37075, Gottingen, Germany
Breast Cancer Res Treat 148:269-77. 2014..Protein expression of epithelial marker CDH1 was clearly decreased. With the breast cancer cell lines, MCF-7-EMT and MCF-7 WT cells, we have an excellent model of cells for further studies of EMT and invasion in vitro and in vivo. ..
- N-cadherin mediates the migration of MCF-10A cells undergoing bone morphogenetic protein 4-mediated epithelial mesenchymal transitionKi Sook Park
East West Medical Research Institute College of Medicine, Kyung Hee University, Seoul, 130 701, Korea
Tumour Biol 36:3549-56. 2015..Thus, active canonical BMP4 signaling is important for the migration and EMT of mammary epithelial cells. Moreover, the decrease in E-cadherin and/or increase in N-cadherin may be required for BMP4-induced migration and EMT. ..
- Mechanisms of N-Cadherin Mediated Breast CA MetastasisRachel Hazan; Fiscal Year: 2005..abstract_text> ..
- Cadherin Mediated Cell-Cell Interactions in the Bone MicroenvironmentRoberto Civitelli; Fiscal Year: 2013..members of the cadherin superfamily of cell adhesion molecules, in particular cadherin-11 (Cad11) and N-cadherin (Ncad)...
- Signals Regulating SAG DevelopmentJames A Marrs; Fiscal Year: 2010..We propose a novel approach to the study of this process, which fits NIDCD Program Announcement PA-07-127. ..
- An investigation of guidance mechanisms regulating neuronal migrationSarah J Wanner; Fiscal Year: 2013..Preliminary experiments have shown that N-cadherin (Ncad), a prominent cell adhesion molecule in the nervous system, is required for facial branchiomotor neuron (FBMN) ..
- Mechanism of differential adhesion by protocadherin-cadherin complexesJAMES DAVID JONTES; Fiscal Year: 2013..In our previous work, we showed that Protocadherin-19 (Pcdh19) associates with N-cadherin (Ncad) to form a heteromeric cis-complex...
- Axon-glial interactions mediating axonal regenerationToby A Ferguson; Fiscal Year: 2013..Neuronal cadherin (NCAD), a homophilic cell adhesion molecule expressed by both axons and Schwann cells is an attractive candidate to ..
- SWI/SNF & Yolk Sac DevelopmentTerry Magnuson; Fiscal Year: 2010..Misregulation of these pathways are known to regulate proliferation, migration, differentiation and apoptosis, all of which are key steps in yolk sac development. ..
- CADHERIN REGULATION OF OSTEOBLAST FUNCTIONRoberto Civitelli; Fiscal Year: 2004..members of the cadherin superfamily of cell adhesion molecules, in particular cadherin-11 (cadl1) and N-cadherin (Ncad)...
- DEVELOPMENT OF MULTIFUNCTIONAL CONTRAST AGENTSLajos Balogh; Fiscal Year: 2006..Each NCAD will have a specific size (5, 10 and 25 nm), a specific surface (well-defined positive or negative net surface ..
- BRAINS RULE! NEUROSCIENCE EXPOSITIONSAndrea Zardetto Smith; Fiscal Year: 2004..WIN, AOTA, APTA-Neurology Section, AANN, the Foundation for Biomedical Research, the NCAD, the NIMH Office of Neuroinformatics, Boys and Girls Club of America, the American Indian Science and Engineering ..
- Cell Interactions in Synapes Formation and FunctionJuan Bruses; Fiscal Year: 2005....
- RAS MEDIATED, ANCHORAGE INDEPENDENT GROWTHROBERT KRAUSS; Fiscal Year: 2002..Such genes represent potential mediators of the transformed phenotype. ..
- Mice That Lack CDO: A Model for Mild HoloprosencephalyROBERT KRAUSS; Fiscal Year: 2004....
- Role of CD164 in Skeletal MyogenesisROBERT KRAUSS; Fiscal Year: 2008..This research should therefore shed light on fundamental processes by which skeletal muscles develop. [unreadable] [unreadable]..
- Gene-Environment Interaction in Holoprosencephaly: Role of Fetal Alcohol ExposureROBERT KRAUSS; Fiscal Year: 2008..Such information may have important public health impact and could ultimately aid in the counseling of HPE mutation carriers. [unreadable] [unreadable] [unreadable]..
- Role of Plakophilin-1 in HNSCCJames Wahl; Fiscal Year: 2009..Defining the nuclear function of plakophilin-1 will lay the ground work for identifying new prognostic markers for HNSCC and also potential targets for novel therapeutic strategies for treating the disease. ..