MYH15

Summary

Gene Symbol: MYH15
Description: myosin heavy chain 15
Alias: myosin-15, myosin, heavy polypeptide 15
Species: human

Top Publications

  1. ncbi Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family
    Philippe R Desjardins
    Department of Surgery, School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Mol Biol Evol 19:375-93. 2002
  2. ncbi Evolution of sarcomeric myosin heavy chain genes: evidence from fish
    Katrina McGuigan
    Institute of Neurosciences, University of Oregon, USA
    Mol Biol Evol 21:1042-56. 2004
  3. ncbi Myosin gene mutation correlates with anatomical changes in the human lineage
    Hansell H Stedman
    Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 428:415-8. 2004
  4. pmc Genome-Wide Association Study Identification of Novel Loci Associated with Airway Responsiveness in Chronic Obstructive Pulmonary Disease
    Nadia N Hansel
    1 Department of Medicine, School of Medicine and
    Am J Respir Cell Mol Biol 53:226-34. 2015
  5. doi Expression and identification of 10 sarcomeric MyHC isoforms in human skeletal muscles of different embryological origin. Diversity and similarity in mammalian species
    Francesco Mascarello
    Department of Comparative Biomedicine and Food Science, University of Padova, Viale dell Universita 16, Legnaro, 35020 Padova, Italy Electronic address
    Ann Anat 207:9-20. 2016
  6. pmc Co-expression analysis and identification of fecundity-related long non-coding RNAs in sheep ovaries
    Xiangyang Miao
    Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China
    Sci Rep 6:39398. 2016
  7. doi Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project
    Tiphaine Oudot-Mellakh
    INSERM UMR_S 937, ICAN Institute, Universite Pierre et Marie Curie, Paris 6, F 75013, Paris, France
    Br J Haematol 157:230-9. 2012
  8. ncbi Developmental expression and comparative genomic analysis of Xenopus cardiac myosin heavy chain genes
    Robert J Garriock
    Department of Cell Biology and Anatomy, University of Arizona Health Sciences Center, Tucson, Arizona 95724, USA
    Dev Dyn 233:1287-93. 2005
  9. ncbi Five common gene variants identify elevated genetic risk for coronary heart disease
    Lance A Bare
    Celera, Alameda, California 94502, USA
    Genet Med 9:682-9. 2007
  10. pmc Gene variants associated with ischemic stroke: the cardiovascular health study
    May M Luke
    Celera, Alameda, California 94502, USA
    Stroke 40:363-8. 2009

Research Grants

  1. LESLIE ANNE LEINWAND; Fiscal Year: 2016

Scientific Experts

  • F Mascarello
  • Katrina McGuigan
  • H H Stedman
  • Lance A Bare
  • May M Luke
  • LESLIE ANNE LEINWAND
  • Xiangyang Miao
  • Nadia N Hansel
  • Tiphaine Oudot-Mellakh
  • Alberto C Rossi
  • Robert J Garriock
  • Qingmiao Luo
  • Xiaoyu Qin
  • Huijing Zhao
  • Kathleen C Barnes
  • Pieter S Hiemstra
  • Michael H Cho
  • Andrew Sandford
  • John Connett
  • Ingo Ruczinski
  • David Sparrow
  • Robert A Wise
  • Don D Sin
  • Chris D Pascoe
  • Lili Huang
  • H Marike Boezen
  • Augusto A Litonjua
  • Dirkje S Postma
  • Nicholas Rafaels
  • Carole Ober
  • Yohan Bosse
  • Denise Daley
  • Bryna A Arsenault
  • Peter D Pare
  • Enid R Neptune
  • W Mark Elliott
  • Candelaria Vergara
  • Maarten van den Berge
  • Rasika A Mathias
  • Terri H Beaty
  • Philippe R Desjardins
  • Diana Zelenika
  • Choumous Kallel
  • David Alexandre Tregouet
  • William Cohen
  • Pierre Emmanuel Morange
  • Marine Germain
  • Noemie Saut
  • Mark Lathrop
  • Carlo Reggiani
  • Stefano Schiaffino
  • Cristina Mammucari
  • Carla Argentini
  • Paul A Krieg
  • Stryder M Meadows
  • James M Burkman
  • Leonard A Allmond
  • Joseph B Shrager

Detail Information

Publications12

  1. ncbi Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family
    Philippe R Desjardins
    Department of Surgery, School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Mol Biol Evol 19:375-93. 2002
    ..One of the novel human genes is found to have introns at positions shared only with the molluscan catchin/MyHC gene, providing evidence for the structure of a pre-Cambrian ancestral gene...
  2. ncbi Evolution of sarcomeric myosin heavy chain genes: evidence from fish
    Katrina McGuigan
    Institute of Neurosciences, University of Oregon, USA
    Mol Biol Evol 21:1042-56. 2004
    ..Our analyses inferred two other ancestral vertebrate MYH genes, giving rise to human MYH14 and MYH15 and their homologues...
  3. ncbi Myosin gene mutation correlates with anatomical changes in the human lineage
    Hansell H Stedman
    Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nature 428:415-8. 2004
    ..This represents the first proteomic distinction between humans and chimpanzees that can be correlated with a traceable anatomic imprint in the fossil record...
  4. pmc Genome-Wide Association Study Identification of Novel Loci Associated with Airway Responsiveness in Chronic Obstructive Pulmonary Disease
    Nadia N Hansel
    1 Department of Medicine, School of Medicine and
    Am J Respir Cell Mol Biol 53:226-34. 2015
    ..assessed for the top 10 markers identified, and immunohistochemistry assays assessed protein staining for SGCD and MYH15. Four genes were identified within the top 10 associations with airway responsiveness. Markers on chromosome 9p21...
  5. doi Expression and identification of 10 sarcomeric MyHC isoforms in human skeletal muscles of different embryological origin. Diversity and similarity in mammalian species
    Francesco Mascarello
    Department of Comparative Biomedicine and Food Science, University of Padova, Viale dell Universita 16, Legnaro, 35020 Padova, Italy Electronic address
    Ann Anat 207:9-20. 2016
    ..patterns of expression of the following genes MYH1, MYH2, MYH3, MYH4, MYH6, MYH7, MYH8, MYH13, MYH14/7b and MYH15 were demonstrated in various muscle samples...
  6. pmc Co-expression analysis and identification of fecundity-related long non-coding RNAs in sheep ovaries
    Xiangyang Miao
    Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, China
    Sci Rep 6:39398. 2016
    ..lncRNAs (e.g., NR0B1, XLOC_041882, and MYH15) in the yellow module were mainly involved in the TGF-β signalling pathway, and NYAP1 and BCORL1 were ..
  7. doi Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project
    Tiphaine Oudot-Mellakh
    INSERM UMR_S 937, ICAN Institute, Universite Pierre et Marie Curie, Paris 6, F 75013, Paris, France
    Br J Haematol 157:230-9. 2012
    ..We identified three independent loci associated with ACV (F2, F5 and PROCR) and replicated two independent effects on plasma PC levels at the PROCR locus...
  8. ncbi Developmental expression and comparative genomic analysis of Xenopus cardiac myosin heavy chain genes
    Robert J Garriock
    Department of Cell Biology and Anatomy, University of Arizona Health Sciences Center, Tucson, Arizona 95724, USA
    Dev Dyn 233:1287-93. 2005
    ..Comparative genomic analysis has allowed the detection of a mammalian MHC gene (MyH15) that appears to be the orthologue of vMHC, but evidence suggests that this gene is no longer active.
  9. ncbi Five common gene variants identify elevated genetic risk for coronary heart disease
    Lance A Bare
    Celera, Alameda, California 94502, USA
    Genet Med 9:682-9. 2007
    ....
  10. pmc Gene variants associated with ischemic stroke: the cardiovascular health study
    May M Luke
    Celera, Alameda, California 94502, USA
    Stroke 40:363-8. 2009
    ..The purpose of this study was to determine whether 74 single nucleotide polymorphisms (SNPs), which had been associated with coronary heart disease, are associated with incident ischemic stroke...
  11. pmc Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry
    May M Luke
    Celera, Alameda, California, USA
    Cerebrovasc Dis 28:499-504. 2009
    ..The odds ratios for noncardioembolic stroke were 1.31 (90% CI 1.07-1.60) for rs3900940 in MYH15, 1.24 (90% CI 1.01-1.5) for rs20455 in KIF6, 1.21 (90% CI 0.99-1.49) for rs1010 in VAMP8, and 1.20 (90% CI 0.95-1...
  12. pmc Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles
    Alberto C Rossi
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    J Physiol 588:353-64. 2010
    The mammalian genome contains three ancient sarcomeric myosin heavy chain (MYH) genes, MYH14/7b, MYH15 and MYH16, in addition to the two well characterized clusters of skeletal and cardiac MYHs...

Research Grants1

  1. LESLIE ANNE LEINWAND; Fiscal Year: 2016
    ..These Aims will test the hypotheses that the catalytic an mechanical properties of MYH7b and MYH15 are unique and that MYH7b has specialized functions in muscle and brain...