MUSK

Summary

Gene Symbol: MUSK
Description: muscle associated receptor tyrosine kinase
Alias: CMS9, FADS, muscle, skeletal receptor tyrosine-protein kinase, muscle, skeletal, receptor tyrosine kinase, muscle-specific kinase receptor, muscle-specific tyrosine-protein kinase receptor
Species: human

Top Publications

  1. ncbi Protein tyrosine kinase activity in human thyroid papillary carcinoma
    Y Yasuda
    Second Department of Surgery, Hyogo College of Medicine, Japan
    Acta Oncol 31:409-12. 1992
  2. pmc Distinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializations
    H Zhou
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 146:1133-46. 1999
  3. doi Environmental exposure of pharmaceuticals and musk fragrances in the Somes River before and after upgrading the municipal wastewater treatment plant Cluj-Napoca, Romania
    Zaharie Moldovan
    Department of Mass Spectrometry, National Institute of Research and Development for Isotopic and Molecular Technology, INCDTIM, Cluj Napoca, Romania
    Environ Sci Pollut Res Int 16:S46-54. 2009
  4. pmc The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions
    Ayumi Kudoh
    Department of Microbiology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    Retrovirology 11:9. 2014
  5. ncbi Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction
    E D Apel
    Department of Anatomy and Neurobiology and Department of Pediatrics, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 275:31986-95. 2000
  6. ncbi Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury
    D M Valenzuela
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Neuron 15:573-84. 1995
  7. ncbi Dok-7 mutations underlie a neuromuscular junction synaptopathy
    David Beeson
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Science 313:1975-8. 2006
  8. pmc Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction
    Zhonghua Lu
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 177:1077-89. 2007
  9. doi Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction
    Rebecca N Cole
    School of Medical Sciences Physiology and Bosch Institute, University of Sydney, Sydney, Australia
    Ann Neurol 63:782-9. 2008
  10. doi Clinical phenotype of muscle-specific tyrosine kinase-antibody-positive myasthenia gravis
    Gil I Wolfe
    Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8897, USA
    Ann N Y Acad Sci 1132:71-5. 2008

Research Grants

  1. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
  2. Khalid Matrougui; Fiscal Year: 2014
  3. The central role of c-Met in H. pylori pathogenesis.
    Sarah E Keates; Fiscal Year: 2010
  4. GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATION
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2010
  5. TOPOISOMERASE I INHIBITORS IN LEUKEMIA AND SOLID TUMORS
    Scott H Kaufmann; Fiscal Year: 2010
  6. Philip A Cole; Fiscal Year: 2016
  7. Paul J Chiao; Fiscal Year: 2014
  8. Stevan R Hubbard; Fiscal Year: 2014
  9. Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes
    Jan Novak; Fiscal Year: 2012
  10. Redox regulation of phagocyte NOX2 in inflammation and aging
    Robert A Clark; Fiscal Year: 2013

Detail Information

Publications774 found, 100 shown here

  1. ncbi Protein tyrosine kinase activity in human thyroid papillary carcinoma
    Y Yasuda
    Second Department of Surgery, Hyogo College of Medicine, Japan
    Acta Oncol 31:409-12. 1992
    ..These findings indicate that elevated cytosolic PTK activity may be a potentially useful marker for papillary thyroid carcinoma...
  2. pmc Distinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializations
    H Zhou
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 146:1133-46. 1999
    Agrin released from motor nerve terminals activates a muscle-specific receptor tyrosine kinase (MuSK) in muscle cells to trigger formation of the skeletal neuromuscular junction...
  3. doi Environmental exposure of pharmaceuticals and musk fragrances in the Somes River before and after upgrading the municipal wastewater treatment plant Cluj-Napoca, Romania
    Zaharie Moldovan
    Department of Mass Spectrometry, National Institute of Research and Development for Isotopic and Molecular Technology, INCDTIM, Cluj Napoca, Romania
    Environ Sci Pollut Res Int 16:S46-54. 2009
    ..The data should support the improvement of existing WWTPs and implementation of new ones where necessary and, therefore, minimize the input of contaminants into ambient waters...
  4. pmc The phosphorylation of HIV-1 Gag by atypical protein kinase C facilitates viral infectivity by promoting Vpr incorporation into virions
    Ayumi Kudoh
    Department of Microbiology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
    Retrovirology 11:9. 2014
    ..In our present study, we identified this kinase using a proteomic approach and further delineate its role in HIV-1 replication...
  5. ncbi Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction
    E D Apel
    Department of Anatomy and Neurobiology and Department of Pediatrics, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 275:31986-95. 2000
    ..Finally, we identify a homologous gene, syne-2, that is expressed in an overlapping but distinct pattern...
  6. ncbi Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury
    D M Valenzuela
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Neuron 15:573-84. 1995
    ..Here we identify a receptor tyrosine kinase (RTK) specific to skeletal muscle, which we term "MuSK" for muscle-specific kinase...
  7. ncbi Dok-7 mutations underlie a neuromuscular junction synaptopathy
    David Beeson
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Science 313:1975-8. 2006
    ..We showed that recessive inheritance of mutations in Dok-7, which result in a defective structure of the neuromuscular junction, is a cause of CMS with proximal muscle weakness...
  8. pmc Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction
    Zhonghua Lu
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 177:1077-89. 2007
    ..ligase and have demonstrated that it regulates the surface expression of muscle-specific receptor tyrosine kinase (MuSK), the key organizer of postsynaptic development at the mammalian neuromuscular junction...
  9. doi Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction
    Rebecca N Cole
    School of Medical Sciences Physiology and Bosch Institute, University of Sydney, Sydney, Australia
    Ann Neurol 63:782-9. 2008
    ..receptor (anti-AChR) antibodies are instead seropositive for antibodies against the muscle-specific kinase (anti-MuSK-positive)...
  10. doi Clinical phenotype of muscle-specific tyrosine kinase-antibody-positive myasthenia gravis
    Gil I Wolfe
    Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8897, USA
    Ann N Y Acad Sci 1132:71-5. 2008
    Antibodies to muscle-specific receptor tyrosine kinase (MuSK-Ab) are detected in approximately 40% of generalized acetylcholine receptor (AChR) antibody-negative myasthenia gravis (MG)...
  11. doi Response to therapy in myasthenia gravis with anti-MuSK antibodies
    Amelia Evoli
    Department of Neurosciences, Catholic University, Largo F Vito 1, 00168 Rome, Italy
    Ann N Y Acad Sci 1132:76-83. 2008
    Myasthenia gravis (MG) with antibodies against the muscle-specific tyrosine kinase (MuSK abs) is often a severe disease requiring aggressive treatment...
  12. pmc Mutations in MUSK causing congenital myasthenic syndrome impair MuSK-Dok-7 interaction
    Ricardo A Maselli
    Department of Neurology, School of Veterinary Medicine, University of California Davis, Davis, CA 95618, USA
    Hum Mol Genet 19:2370-9. 2010
    ..syndrome (CMS) caused by two missense mutations in the gene encoding the muscle specific receptor tyrosine kinase (MUSK). The identified MUSK mutations M605I and A727V are both located in the kinase domain of MuSK...
  13. doi Muscle specific kinase: organiser of synaptic membrane domains
    Nazanin Ghazanfari
    Physiology and Bosch Institute, Anderson Stuart Bldg F13, The University of Sydney, Sydney, NSW 2006, Australia
    Int J Biochem Cell Biol 43:295-8. 2011
    Muscle Specific Kinase (MuSK) is a transmembrane tyrosine kinase vital for forming and maintaining the mammalian neuromuscular junction (NMJ: the synapse between motor nerve and skeletal muscle)...
  14. pmc Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK)
    Wei Zhang
    Molecular Neurobiology Program, Helen L and Martin S Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University Medical School, New York, New York 10016, USA
    J Biol Chem 286:40624-30. 2011
    ..region in a manner that depends upon Lrp4, a member of the LDL receptor family, and muscle-specific kinase (MuSK), a receptor tyrosine kinase...
  15. ncbi The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo
    T M DeChiara
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 85:501-12. 1996
    ..We have generated mice with a targeted disruption of the gene encoding MuSK, a receptor tyrosine kinase selectively localized to the postsynaptic muscle surface...
  16. ncbi Rapsyn is required for MuSK signaling and recruits synaptic components to a MuSK-containing scaffold
    E D Apel
    Department of Molecular Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 18:623-35. 1997
    ..The receptor tyrosine kinase MuSK is a component of the agrin receptor, while the cytoplasmic protein rapsyn is necessary for the clustering of AChRs ..
  17. ncbi MUSK, a new target for mutations causing congenital myasthenic syndrome
    Frédéric Chevessier
    INSERM U582 and IFR Cur, Muscle, Vaisseaux, Institut de Myologie, Hôpital de la Salpêtrière and Université Pierre et Marie Curie, Paris, France
    Hum Mol Genet 13:3229-40. 2004
    ..transmission dysfunction due to mutations in the gene encoding the muscle-specific receptor tyrosine kinase (MuSK). Gene analysis identified two heteroallelic mutations, a frameshift mutation (c...
  18. ncbi The muscle protein Dok-7 is essential for neuromuscular synaptogenesis
    Kumiko Okada
    Department of Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Science 312:1802-5. 2006
    The formation of the neuromuscular synapse requires muscle-specific receptor kinase (MuSK) to orchestrate postsynaptic differentiation, including the clustering of receptors for the neurotransmitter acetylcholine...
  19. doi Refinement of the clinical phenotype in musk-related congenital myasthenic syndromes.
    V Mihaylova
    Neurology 73:1926-8. 2009
  20. doi Mutations causing DOK7 congenital myasthenia ablate functional motifs in Dok-7
    Johko Hamuro
    Department of Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Yushima, Tokyo 113 8510, Japan
    J Biol Chem 283:5518-24. 2008
    Dok-7 is a cytoplasmic activator of muscle-specific receptor-tyrosine kinase (MuSK). Both Dok-7 and MuSK are required for neuromuscular synaptogenesis...
  21. pmc Activation of rabbit platelets by Ca2+ influx and thromboxane A2 release in an external Ca(2+)-dependent manner by zooxanthellatoxin-A, a novel polyol
    M C Rho
    Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Br J Pharmacol 115:433-40. 1995
    ..The resulting increase in [Ca2+]i subsequently stimulates the secondary release of TXA2 from platelets. Furthermore, the response to ZT-A may be associated with tyrosine phosphorylation...
  22. ncbi Control of DAF-7 TGF-(alpha) expression and neuronal process development by a receptor tyrosine kinase KIN-8 in Caenorhabditis elegans
    M Koga
    Department of Biology, Graduate School of Sciences, Kyushu University, Fukuoka, Japan
    Development 126:5387-98. 1999
    ..KIN-8 is required for the process development of ASI, and also involved in promotion of daf-7 expression through a physiological or developmental function...
  23. ncbi Hybrid tyrosine kinase/cytokine receptors transmit mitogenic signals in response to ligand
    R E Pacifici
    Department of Molecular Biology, Amgen Inc, Amgen Center, Thousand Oaks, California 91320
    J Biol Chem 269:1571-4. 1994
    ....
  24. ncbi Signaling mechanisms of basic fibroblast growth factor in arterial cells from genetically hypertensive rat
    D L Zhu
    CNRS URA 1482, Laboratoire de Pharmacologie, , Paris, France
    Am J Hypertens 7:351-6. 1994
    ..Therefore, one may envisage that bFGF contributes, through paracrine/autocrine mechanisms, to the vascular smooth muscle hyperplasia/hypertrophy in SHR...
  25. ncbi [Budesonide attenuates airway remodeling and modules the expression of Janus protein tyrosine kinase 1, and signal transducers and activators of transcription 6 in asthma: an experiment with mice]
    Xiao hong Chen
    Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China
    Zhonghua Yi Xue Za Zhi 87:1627-32. 2007
    ..To investigate the effects of budesonide (BUD) on the airway remodeling and the expression of Janus protein tyrosine kinases 1 (JAK1) and signal transducer and activator of transcription 6 (STAT6) in asthma...
  26. ncbi Properties of tripartite chimeras between Src and Lck
    A Kashishian
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Oncogene 5:1463-70. 1990
    ..Enzymatic dephosphorylation stimulated the in vitro kinase activity of parental Src, but not of SLS or SLL. These observations suggest that chimeric Src-Lck molecules are regulated in the cell, but not in vitro...
  27. ncbi Insulin action is mimicked by polyclonal antireceptor antibodies that activate the insulin receptor tyrosine kinase
    M Caron
    Laboratoire de Biochimie, INSERM U181, , Paris, France
    Horm Metab Res 21:295-300. 1989
    ..Taken together, these results are consistent with a role for the kinase activity of the insulin receptor in mediating the action of insulin...
  28. ncbi Platelet-derived growth factor. Structure, function and implications in normal and malignant cell growth
    B Westermark
    Department of Pathology, University Hospital, Uppsala, Sweden
    Acta Oncol 32:101-5. 1993
    ..This view is supported by our recent finding that human melanoma cells that have been stably transfected with a PDGF B-chain cDNA, elicit a stroma response when transplanted to nude mice...
  29. ncbi Insulin-receptor tyrosine kinase activity is decreased in erythrocytes from non-obese patients with NIDDM
    R F Santos
    Laboratory of Human Nutrition and Metabolic Diseases, School of Medicine, , Brazil
    Horm Metab Res 26:283-7. 1994
    ..e. decrease in activity) observed in patients with NIDDM is probably related to a reduction in coupling efficiency between insulin binding and the activation of the receptor tyrosine kinase activity...
  30. ncbi Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 337:1-13. 2005
    ..Kit has the potential to participate in multiple signal transduction pathways as a result of interaction with several enzymes and adaptor proteins...
  31. ncbi Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation
    B A Binstadt
    Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Immunity 5:629-38. 1996
    ..These results suggest sequential roles for Lck and SHP-1 in the inhibition of PTK following MHC recognition by NK cells...
  32. ncbi Evaluation of musk contamination of freshwater fish in Italy by accelerated solvent extraction and gas chromatography with mass spectrometric detection
    R Draisci
    Laboratorio Medicina Veterinaria, , Rome, Italy
    J Chromatogr A 814:187-97. 1998
    b>Musk compounds play an important role as perfuming agents for household chemicals, detergents and cosmetics. It has been demonstrated that the oral absorption of these compounds in humans is significant in the case of contaminated fish...
  33. pmc Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation
    L Zeng
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Cell Biol 20:9212-24. 2000
    ..We conclude that Vav3 mediates RPTK signaling and regulates GTPase activity, its native and mutant forms are able to modulate cell morphology, and it has the potential to induce cell transformation...
  34. ncbi A cyclic adenosine 3',5'-monophosphate-induced tyrosine phosphorylation of Syk protein tyrosine kinase in the flagella of boar spermatozoa
    Hiroshi Harayama
    The Graduate School of Science and Technology, Kobe University, Kobe, Japan
    Mol Reprod Dev 69:436-47. 2004
    ..Based on these findings, we have concluded that the cAMP-PKA signaling is linked to the Ca2+-independent tyrosine phosphorylation of Syk in the connecting and principal pieces of boar spermatozoa...
  35. ncbi Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 338:1307-15. 2005
    ..STI-571 binds to Kit and Bcr-Abl (the oncoprotein of chronic myelogenous leukemia) at their ATP-binding sites...
  36. ncbi The protein-tyrosine kinase substrate, calpactin I heavy chain (p36), is part of the primer recognition protein complex that interacts with DNA polymerase alpha
    H K Jindal
    Department of Biochemistry, University of Nebraska Medical Center, Omaha 68198
    J Biol Chem 266:5169-76. 1991
    ..The biochemical and immunological data presented here revealing the identity of PRP 1 as calpactin I provide evidence for one physiological role of calpactin I in the cell...
  37. pmc IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis
    Maria Isabel Leite
    Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK
    Brain 131:1940-52. 2008
    ..Antibodies to muscle specific kinase [MuSK; MuSK antibody positive myasthenia gravis (MuSK-MG)] make up a variable proportion of the remaining 20%...
  38. ncbi Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines
    T Torigoe
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia
    Blood 80:617-24. 1992
    ..These observations provide the first example of an IL-3--regulable PTK, and strongly suggest that the p53/56-LYN kinase participates in early IL-3--initiated signalling events, at least in some human leukemic cell lines...
  39. ncbi Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis
    Amelia Evoli
    Department of Neuroscience, Catholic University, Roma, Italy
    Brain 126:2304-11. 2003
    ..In these patients, IgG antibodies against the muscle-specific kinase (MuSK) have been described, which reduced agrin-induced AChR clustering in vitro...
  40. ncbi Activation of p58c-fgr and p53/56lyn in adherent human neutrophils: evidence for a role of divalent cations in regulating neutrophil adhesion and protein tyrosine kinase activities
    S R Yan
    Institute of General Pathology, University of Verona, Italy
    J Inflamm 45:297-311. 1995
    ....
  41. ncbi Phorbol ester stimulates phosphorylation on serine 1327 of the human insulin receptor
    R E Lewis
    Eppley Institute for Research in Cancer and Allied Disease, University of Nebraska Medical Center, Omaha 68198 6805
    J Biol Chem 269:26259-66. 1994
    ....
  42. doi The reproductive activity in the testis of Podarcis s. sicula involves D-aspartic acid: a study on c-kit receptor protein, tyrosine kinase activity and PCNA protein during annual sexual cycle
    Franca Raucci
    Department of Life Sciences, Second University of Naples, Via Vivaldi 43, 81100 Caserta, Italy
    Gen Comp Endocrinol 161:373-83. 2009
    ..sicula, suggesting that a sequential cascade of a functional relationship between testosterone levels, c-kit receptor protein, tyrosine kinase activity and PCNA could be partly mediated by D-aspartic acid...
  43. ncbi The carriage of larval echinococcus multilocularis and other cestodes by the musk rat (Ondatra zibethicus) along the Ourthe River and its tributaries (Belgium)
    A Mathy
    Department of Infectious and Parasitic Diseases, University of Liege, 4000 Liege, Belgium
    J Wildl Dis 45:279-87. 2009
    ..This study was designed to evaluate the carriage of the larval form of E. multilocularis and other cestodes in a musk rat (Ondatra zibethicus) population trapped along the Ourthe River (southeastern Belgium)...
  44. ncbi Expression of a novel receptor tyrosine kinase gene and a paired-like homeobox gene provides evidence of differences in patterning at the oral and aboral ends of hydra
    D M Bridge
    Department of Biological Chemistry and Developmental Biology Center, University of California, Irvine, California 92697 1700, USA
    Dev Biol 220:253-62. 2000
    ..As predicted by this hypothesis, grafts reversing the orientation of evaginating body column tissue also reverse the orientation of asymmetrical gene expression...
  45. ncbi Human recombinant alpha 2-HS glycoprotein is produced in insect cells as a full length inhibitor of the insulin receptor tyrosine kinase
    L Kalabay
    3rd Department of Medicine, Semmelweis University Medical School, Budapest, Hungary
    Horm Metab Res 30:1-6. 1998
    ..1)...
  46. ncbi Space flight modulates signal transduction pathway of growth factor receptors in rat osteoblasts
    Y Kumei
    Tokyo Medical and Dental Univ
    Biol Sci Space 13:142-3. 1999
    ..The purpose of this study is to investigate the mRNA levels for PDGF-beta receptor, EGF receptor, Shc, and c-fos in rat osteoblasts during space flight...
  47. ncbi Selective inhibition of the epidermal growth factor receptor tyrosine kinase by BIBX1382BS and the improvement of growth delay, but not local control, after fractionated irradiation in human FaDu squamous cell carcinoma in the nude mouse
    M Baumann
    Clinic of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany
    Int J Radiat Biol 79:547-59. 2003
    ..FaDu human squamous cell carcinoma is epidermal growth factor receptor positive and significant repopulation during fractionated irradiation was demonstrated in previous experiments...
  48. ncbi Localization and regulation of MuSK at the neuromuscular junction
    D C Bowen
    Regeneron Pharmaceuticals, Tarrytown, New York 10591, USA
    Dev Biol 199:309-19. 1998
    The receptor tyrosine kinase, MuSK, is required for the formation of the neuromuscular junction (NMJ) where MuSK becomes phosphorylated when exposed to neuronally synthesized isoforms of agrin...
  49. pmc Activated Fes protein tyrosine kinase induces terminal macrophage differentiation of myeloid progenitors (U937 cells) and activation of the transcription factor PU.1
    Jynho Kim
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Cell Biol 22:1903-18. 2002
    ..Our results strongly implicate Fes as a key regulator of terminal macrophage differentiation and identify PU.1 as a transcription factor that may mediate some of its biological activities in myeloid cells...
  50. pmc Partial purification and characterization of the lck protein-tyrosine kinase from bovine thymus
    Q M Wang
    Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Purdue University, West Lafayette, IN 47907
    Biochem J 279:567-74. 1991
    ..The phosphorylation of angiotensin I by bovine thymus p56lck was weakly activated by polyionic compounds such as heparin and polylysine, and was strongly activated by high concentrations of NaCl...
  51. ncbi Glucose transporter (GLUT 4) content and insulin receptor kinase activity in muscles of the LA/N-cp rat
    M Kern
    Department of Medicine, Stanford University School of Medicine, California
    Horm Metab Res 26:129-32. 1994
    ..These data indicate that there are at least two defects in the insulin action cascade in muscle from LA/N-cp rats that contribute to the insulin resistance in these animals...
  52. ncbi Organization of the human PTK7 gene encoding a receptor protein tyrosine kinase-like molecule and alternative splicing of its mRNA
    Jae Won Jung
    National Research Laboratory of Cellular Biochemistry, Department of Biochemistry, College of Science, and Protein Network Research Center, Yonsei University, Seoul, South Korea
    Biochim Biophys Acta 1579:153-63. 2002
    ..Our findings suggest that PTK7 is evolutionarily distinct from other RPTKs, and that the alternative splicing of PTK7 mRNA may contribute to its diverse function in cell signaling...
  53. ncbi Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain
    Eunmi Hong
    Department of Biochemistry and Protein Network Research Center, College of Science, Yonsei University, Seoul 120 749, Korea
    J Biol Chem 279:29700-8. 2004
    ..The solution structure together with data from the ligand binding mode of PTK6-SH2 provides insight into the molecular basis of the autoinhibitory role of PTK6...
  54. ncbi Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase
    J L Countaway
    Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester 01605
    J Biol Chem 267:1129-40. 1992
    ..This regulatory phosphorylation site is located at the carboxyl terminus of the EGF receptor within the subdomain that binds src homology 2 regions of signaling molecules...
  55. ncbi Characterization of B61, the ligand for the Eck receptor protein-tyrosine kinase
    H Shao
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
    J Biol Chem 270:5636-41. 1995
    ..Finally, the gene for B61 was localized to a specific position on mouse chromosome 3 by interspecific back-cross analysis...
  56. ncbi Emerging pollutants in the North Sea in comparison to Lake Ontario, Canada, data
    Jens Arne Andresen
    Institute for Environmental Analytical Chemistry, University Duisburg Essen, Universitiitsstrage 15, 45141 Essen, Germany
    Environ Toxicol Chem 26:1081-9. 2007
    ..study, the concentrations and fate of contaminants such as organophosphate flame retardants and plasticizers, musk compounds such as galaxolide (HHCB), tonalide (AHTN), musk ketone and musk xylene, the bactericide triclosan, as ..
  57. ncbi Neocortical neurons lacking the protein-tyrosine kinase B receptor display abnormal differentiation and process elongation in vitro and in vivo
    M A Gates
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroscience 98:437-47. 2000
    ....
  58. doi Identification of Erbin interlinking MuSK and ErbB2 and its impact on acetylcholine receptor aggregation at the neuromuscular junction
    Luca Simeone
    Institut fur Biochemie, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    J Neurosci 30:6620-34. 2010
    ..In the CNS, Erbin interacts with PSD-95. Furthermore, agrin-MuSK signaling initiates formation of AChR aggregates at the postsynaptic membrane...
  59. ncbi Correlation of pharmacokinetics with the antitumor activity of Cetuximab in nude mice bearing the GEO human colon carcinoma xenograft
    F R Luo
    Pharmaceutical Research Institute, Oncology Drug Discovery, Bristol Myers Squibb Company, Princeton, NJ 08543, USA
    Cancer Chemother Pharmacol 56:455-64. 2005
    ..In the present study, we characterized the PK of Cetuximab in nude mice at efficacious dose levels and further compared the preclinical optimal dose and active plasma drug concentration with those determined in clinical studies...
  60. pmc Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction
    Tatiana Cheusova
    Institut fur Biochemie, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    Genes Dev 20:1800-16. 2006
    The release of Agrin by motoneurons activates the muscle-specific receptor tyrosine kinase (MuSK) as the main organizer of subsynaptic specializations at the neuromuscular junction. MuSK downstream signaling is largely undefined...
  61. ncbi Myasthenia gravis experimentally induced with muscle-specific kinase
    Kazuhiro Shigemoto
    Department of Preventive Medicine, Ehime University School of Medicine, Ehime, Japan
    Ann N Y Acad Sci 1132:93-8. 2008
    Here we present the first evidence that muscle-specific kinase (MuSK) antigen can cause myasthenia in animals...
  62. ncbi Protein tyrosine kinase in colorectal adenoma
    T Hatada
    Department of Surgery, Hyogo College of Medicine, Japan
    Acta Oncol 32:23-8. 1993
    ....
  63. ncbi Differential regulation of fyn-associated protein tyrosine kinase activity by macrophage colony-stimulating factor (M-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF)
    Y Li
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201
    J Leukoc Biol 57:484-90. 1995
    ..Collectively, our data suggest that the activation of fyn kinase is closely associated with the acquisition of adherent capacity in maturing macrophages...
  64. ncbi Regulation of eicosanoid biosynthesis in the macrophage. Involvement of protein tyrosine phosphorylation and modulation by selective protein tyrosine kinase inhibitors
    K B Glaser
    Division of Immunopharmacology, Wyeth Ayerst Research, Princeton, NJ 08543 8000
    Biochem Pharmacol 45:711-21. 1993
    ..The use of selective PTK inhibitors suggests a common role for PTK and tyrosine phosphorylation in eicosanoid biosynthesis in the murine peritoneal macrophage...
  65. ncbi Activation of epidermal growth factor receptor by epidermal growth factor
    J M Sherrill
    Department of Chemistry, University of California, San Diego, La Jolla 92093 0506, USA
    Biochemistry 35:5705-18. 1996
    ..In this mechanism, dimeric EGF receptor must be occupied by two molecules of EGF for enzymatic activity to be expressed...
  66. ncbi A severe outbreak of contagious ecthyma (orf) in a free-ranging musk ox (Ovibos moschatus) population in Norway
    Turid Vikøren
    National Veterinary Institute, Section for Wildlife Diseases, Oslo, Norway
    Vet Microbiol 127:10-20. 2008
    During July-October 2004, 19 (18 calves, 1 yearling) free-ranging musk oxen (Ovibos moschatus) at Dovre, Norway, were observed with contagious echtyma-like lesions, and 16 of them were euthanized...
  67. pmc The nonreceptor protein-tyrosine kinase CSK complexes directly with the GTPase-activating protein-associated p62 protein in cells expressing v-Src or activated c-Src
    K Neet
    Graduate Program in Neurosciences, University of California, San Diego, La Jolla 92093, USA
    Mol Cell Biol 15:4908-20. 1995
    ..Our results suggest that GAP-A.p62 may function as a docking protein and may mediate translocation of proteins, including GAP and CSK, to membrane or cytoskeletal regions upon c-Src activation...
  68. ncbi Production and localization of Muc4/sialomucin complex and its receptor tyrosine kinase ErbB2 in the rat lacrimal gland
    M E Arango
    Department of Cell Biology and Anatomy, University of Miami School of Medicine, Florida 33101, USA
    Invest Ophthalmol Vis Sci 42:2749-56. 2001
    ..To show the presence and forms of sialomucin complex (rat Muc4) and receptor tyrosine kinase ErbBs in the rat lacrimal gland and analyze for complexes of ErbB2 and its ligand Muc4...
  69. pmc Fully automated synthesis of (phospho)peptide arrays in microtiter plate wells provides efficient access to protein tyrosine kinase characterization
    Carl Saxinger
    Center for Cancer Research, NCI, Building 1052, Frederick, MD, 21702, USA
    BMC Immunol 6:1. 2005
    ....
  70. ncbi Population structure of wild musk shrews (Suncus murinus) in Asia based on mitochondrial DNA variation, with research in Cambodia and Bhutan
    Megumi Kurachi
    Graduate School of Bioagricultural Sciences, Nagoya University, Furocho, Chikusa, Nagoya 464 8601, Japan
    Biochem Genet 45:165-83. 2007
    The musk shrew (Suncus murinus) is a small mammalian species belonging to Insectivora. It is widely distributed in Asia...
  71. doi Epidemiological and immunological profile of muscle-specific kinase myasthenia gravis in Greece
    P Tsiamalos
    Department of Pharmacy, University of Patras, Patras, Greece
    Eur J Neurol 16:925-30. 2009
    The purposes of this study were to determine the epidemiological characteristics of muscle-specific kinase-myasthenia gravis (MuSK-MG) in Greece and the IgG subclass of the anti-MuSK antibodies.
  72. ncbi The Agrin/MuSK signaling pathway is spatially segregated from the neuregulin/ErbB receptor signaling pathway at the neuromuscular junction
    J C Trinidad
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 20:8762-70. 2000
    The neuregulin/erbB receptor and agrin/MuSK pathways are critical for communication between the nerve, muscle, and Schwann cell that establishes the precise topological arrangement at the vertebrate neuromuscular junction (NMJ)...
  73. ncbi Trends in the musk xylene concentrations in plasma samples from the general population from 1992/1993 to 1998 and the relevance of dermal uptake
    H U Käfferlein
    Institut und Poliklinik fur Arbeits Sozial und Umweltmedizin, Universitat Erlangen, Erlangen, Germany
    Int Arch Occup Environ Health 74:470-6. 2001
    b>Musk xylene (MX), an environmentally important nitromusk compound, is used in different fragrances and soaps as substitute for natural musk. MX is known to occur in breast milk and plasma samples from the general population...
  74. pmc The function of cortactin in the clustering of acetylcholine receptors at the vertebrate neuromuscular junction
    Raghavan Madhavan
    Department of Biology, The Hong Kong University of Science and Technology, Kowloon, Hong Kong, China
    PLoS ONE 4:e8478. 2009
    ..AChRs) at the vertebrate neuromuscular junction (NMJ) depends on the activation of the muscle receptor tyrosine MuSK by neural agrin...
  75. ncbi Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction
    Alexander J Finn
    Department of Pharmacology and Cancer Biology, Box 3813, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Neurosci 6:717-23. 2003
    Agrin signals through the muscle-specific receptor tyrosine kinase (MuSK) to cluster acetylcholine receptors (AChRs) on the postsynaptic membrane of the neuromuscular junction (NMJ)...
  76. doi The Ig1/2 domain of MuSK binds to muscle surface and is involved in acetylcholine receptor clustering
    Qiang Wang
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Neurosignals 16:246-53. 2008
    ..b>MuSK, a receptor tyrosine kinase, appears to be a key component of the agrin receptor complex...
  77. ncbi PI3-kinase is involved in mitogenic signaling by the oncogenic receptor tyrosine kinase Xiphophorus melanoma receptor kinase in fish melanoma
    C Wellbrock
    Biocenter Theodor Boveri Institut, University of Wurzburg, Wurzburg, Germany
    Exp Cell Res 251:340-9. 1999
    ..Together these data demonstrate that PI3-kinase is a substrate of the oncogenic Xmrk receptor and plays a significant role in mitogenic signaling of melanoma cells and the formation of malignant melanoma in Xiphophorus...
  78. pmc The in vitro and in vivo phosphotyrosine map of activated MuSK
    A Watty
    Molecular Neurobiology Program, Skirball Institute, New York University Medical School, 540 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 97:4585-90. 2000
    The muscle-specific receptor tyrosine kinase MuSK plays a crucial role in neuromuscular synapse formation...
  79. ncbi The full-length, cytoplasmic C-terminus of the beta 2-adrenergic receptor expressed in E. coli acts as a substrate for phosphorylation by protein kinase A, insulin receptor tyrosine kinase, GRK2, but not protein kinase C and suppresses desensitization whe
    S Doronin
    Department of Molecular Pharmacology, University Medical Center, SUNY Stony Brook, Stony Brook, New York 11794, USA
    Protein Expr Purif 20:451-61. 2000
    ..coli acts as a functional domain, displaying fidelity with regard to protein kinase action in vivo and acting as a dominant-negative with respect to agonist-induced desensitization...
  80. ncbi AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity
    Peter Traxler
    Oncology Research, Novartis Institutes for BioMedical Research, Klybeckstrasse, CH 4002 Basel, Switzerland
    Cancer Res 64:4931-41. 2004
    ..Consequently, AEE788 is currently in Phase I clinical trials in oncology...
  81. ncbi Photochemical behaviour of musk tibetene. A chemical and kinetic investigation
    Marisa Canterino
    Universita di Napoli Federico II, Facolta di Ingegneria, Dipartimento di Ingegneria Chimica, P le V Tecchio, 80 80125 Napoli, Italy
    Environ Sci Pollut Res Int 15:182-7. 2008
    Synthetic musk compounds are widely used as additives in personal care and household products...
  82. pmc The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex
    E K Barber
    Division of Tumor Immunology, Dana Farber Cancer Institute, Boston, MA 02115
    Proc Natl Acad Sci U S A 86:3277-81. 1989
    ..Last, we demonstrate directly that members of the CD3 complex, including the gamma, delta, and epsilon chains, as well as a putative zeta subunit, can be phosphorylated at tyrosine residues by the CD4/CD8.p56lck complex...
  83. ncbi Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects
    Yogesh Dwivedi
    Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
    Arch Gen Psychiatry 60:804-15. 2003
    ....
  84. ncbi Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1
    E D Fixman
    Molecular Oncology Group, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H3A 1A1
    J Biol Chem 272:20167-72. 1997
    ....
  85. pmc Antiviral immune responses in Itk-deficient mice
    M F Bachmann
    Department of Pathology, University of Zurich, Switzerland
    J Virol 71:7253-7. 1997
    ..Taken together, the results show that CTL responses are reduced in the absence of Itk whereas antiviral B-cell responses are not affected...
  86. ncbi Tyrosine phosphorylation of the Wiskott-Aldrich syndrome protein by Lyn and Btk is regulated by CDC42
    R Guinamard
    Centre d Immunologie INSERM CNRS de Marseille Luminy, Marseille, France
    FEBS Lett 434:431-6. 1998
    ..We conclude that WASp represents a connection between protein tyrosine kinase signaling pathways and CDC42 function in cytoskeleton and cell growth regulation in hematopoietic cells...
  87. ncbi Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila
    S Kramer
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Development 126:2515-25. 1999
    ..These receptor tyrosine kinase-mediated pathways may share not only intracellular signaling components but also extracellular factors that modulate the strength of the signal...
  88. ncbi CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70
    H Doong
    Molecular Signaling Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland, MD 20892, USA
    Oncogene 19:4385-95. 2000
    ..We propose that CAIR-1/BAG-3 may act as a multifunctional signaling protein linking the Hsp70/Hsc70 pathway with those necessary for activation of the EGF receptor tyrosine kinase signaling pathways...
  89. ncbi Primordial germ cell-somatic cell partnership: a balancing cell signaling act
    A L Kierszenbaum
    Department of Cell Biology and Anatomical Sciences, The City University of New York Medical School, 138th St Convent Avenue, New York, NY 10031, USA
    Mol Reprod Dev 60:277-80. 2001
    ..Information on other inducers of primordial cell survival, such as TER (teratoma) factor, is beginning to emerge...
  90. ncbi Common and distinct signals specify the distribution of blood and vascular cell lineages in Xenopus laevis embryos
    Fumie Iraha
    Graduate School of Science and Technology, Niigata University, 8050 Ikarashi 2, Niigata 950 2181, Japan
    Dev Growth Differ 44:395-407. 2002
    ....
  91. ncbi EphA2 overexpression decreases estrogen dependence and tamoxifen sensitivity
    Ming Lu
    Department of Basic Medical Sciences, Purdue University Cancer Center, West Lafayette, Indiana 47907, USA
    Cancer Res 63:3425-9. 2003
    ..These results have important implications for understanding the molecular basis underlying estrogen dependence and provide further evidence that EphA2 may provide a much-needed therapeutic target for breast cancer...
  92. pmc Superoxide anions are involved in mediating the effect of low K intake on c-Src expression and renal K secretion in the cortical collecting duct
    Elisa Babilonia
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    J Biol Chem 280:10790-6. 2005
    ..We conclude that O(2)(-) and related products play a role in mediating the effect of low K intake on c-Src expression and in suppressing ROMK channel activity and renal K secretion...
  93. ncbi A rare mRNA variant of the human lymphocyte-specific protein tyrosine kinase LCK gene with intron B retention and exon 7 skipping encodes a putative protein with altered SH3-dependent molecular interactions
    Solange Nervi
    Institut de Cancérologie de Marseille, UMR599 INSERM Institut Paoli Calmettes Université de la Méditerranée, 27 Boulevard Lei Roure, 13009 Marseille, France
    Gene 359:18-25. 2005
    ..The biological function of this rare messenger remains to be elucidated...
  94. pmc Vascular wall proteoglycan synthesis and structure as a target for the prevention of atherosclerosis
    Peter J Little
    Cell Biology of Diabetes Laboratory, Baker Heart Research Institute, Melbourne, Australia
    Vasc Health Risk Manag 3:117-24. 2007
    ..Thus, modifying proteoglycan synthesis and structure may represent a prime target to prevent LDL binding and entrapment in the vessel wall and thus prevent the development and progression of atherosclerosis...
  95. pmc Sex-dependent differences in the activity and modulation of N-methyl-d-aspartic acid receptors in rat dorsal root ganglia neurons
    J A McRoberts
    Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Warren Hall, Room 14 103, 900 Veteran Avenue, Los Angeles, CA 90095, USA
    Neuroscience 148:1015-20. 2007
    ..These results identify sex-based differences in both the basal expression and the regulation of the NMDARs in DRG neurons...
  96. doi Regeneration of human epidermis on acellular dermis is impeded by small-molecule inhibitors of EGF receptor tyrosine kinase
    Sofi Forsberg
    Department of Medical Sciences, Dermatology and Venereology, Uppsala University Hospital, 751 85, Uppsala, Sweden
    Arch Dermatol Res 300:505-16. 2008
    ..The study illustrates the usefulness of a dynamic skin model and emphasizes the potential of HER-directed approaches to control epidermal growth in hyperproliferative skin disorders...
  97. pmc Overexpression of Spry1 in chondrocytes causes attenuated FGFR ubiquitination and sustained ERK activation resulting in chondrodysplasia
    Xuehui Yang
    Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, Maine 04074, USA
    Dev Biol 321:64-76. 2008
    ....
  98. pmc HIV-1 Tat mediates degradation of RON receptor tyrosine kinase, a regulator of inflammation
    Parisa Kalantari
    Graduate Program in Pathobiology, Center for Molecular Immunology and Infectious Diseases, Pennsylvania State University, PA 16802, USA
    J Immunol 181:1548-55. 2008
    ....
  99. pmc Downregulation of Spry-1, an inhibitor of GDNF/Ret, causes angiotensin II-induced ureteric bud branching
    Ihor V Yosypiv
    Section of Pediatric Nephrology, Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Kidney Int 74:1287-93. 2008
    ..Enhanced Wnt11 expression induces GDNF in adjacent mesenchyme causing focal bursts of ureteric bud tip cell proliferation, decreased tip cell apoptosis and branching...
  100. doi Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells
    Eystein Oveland
    Proteomic Unit at University of Bergen, Bergen, Norway
    Leuk Res 33:276-87. 2009
    ..THP-1 cells with receptor downregulation were sensitized to idarubicin-induced apoptosis but not cytarabine. We hypothesize that FL-induced receptor modulation may chemosensitize selected AML subsets...
  101. doi Treatment with sunitinib enabled complete resection of massive lymphadenopathy not previously amenable to excision in a patient with renal cell carcinoma
    Jean Jacques Patard
    Rennes University Hospital, Rennes, France
    Eur Urol 55:237-9; quiz 239. 2009
    ..Tumour shrinkage following five cycles of treatment allowed uncomplicated complete resection of the lymphadenopathy. Follow-up after 6 mo showed no evidence of disease recurrence...

Research Grants75

  1. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
    ..We can also analyze tyrosine phosphorylation of the proteins and determine if they physically interact with each other in the embryo. ..
  2. Khalid Matrougui; Fiscal Year: 2014
    ..The goal of our studies is to determine how increased Epidermal Growth Factor Receptor tyrosine kinase activity compromises coronary arteriolar function in type 2 diabetes. ..
  3. The central role of c-Met in H. pylori pathogenesis.
    Sarah E Keates; Fiscal Year: 2010
    ..Results from these studies should lead to a better understanding of the disease mechanisms involved in the development of H. pylori-mediated gastric carcinogenesis. ..
  4. GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATION
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2010
    ....
  5. TOPOISOMERASE I INHIBITORS IN LEUKEMIA AND SOLID TUMORS
    Scott H Kaufmann; Fiscal Year: 2010
    ..Collectively, these studies are designed to provide new insight into the mechanism of action of topo I poisons, and identify strategies for enhancing their efficacy. ..
  6. Philip A Cole; Fiscal Year: 2016
    ..abstract_text> ..
  7. Paul J Chiao; Fiscal Year: 2014
    ..Targeting specific mutations and signaling pathways in pancreatic cancer may be one of the novel therapeutic interventions to treat cancer metastasis. ..
  8. Stevan R Hubbard; Fiscal Year: 2014
    ..To achieve this goal, x-ray crystallography will be employed to determine the three-dimensional structures of the pseudokinase domain and the tandem pseudokinase and tyrosine kinase domains. ..
  9. Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes
    Jan Novak; Fiscal Year: 2012
    ..Relevance: The improved understanding of the pathogenesis of IgAN will identify therapeutic targets for disease-specific therapy of IgAN as well as potential prognostic biomarkers. ..
  10. Redox regulation of phagocyte NOX2 in inflammation and aging
    Robert A Clark; Fiscal Year: 2013
    ....
  11. Inflammatory Proteases, Ubiquitin Proteasome System, and Myocyte Death
    Abdelkarim Sabri; Fiscal Year: 2012
    ....
  12. Jack T Stapleton; Fiscal Year: 2016
    ..Identification and characterization of this HCV E2 - lymphocyte interaction may contribute to the development of novel therapeutic and/or vaccine approaches to HCV, and potentially to related viruses within the Flaviviridae. ..
  13. Apoptotic T Cell Clearance From Murine Lungs
    Jeffrey L Curtis; Fiscal Year: 2010
    ..This project studies a molecule called MerTK that appears to control clearance. Understanding MerTK could lead to new treatments to prevent complications of many types of lung damage. ..
  14. Michael J Mullan; Fiscal Year: 2014
    ..We have identified CD40 signaling as a potentially key modulator of both amyloid and tau pathology and this proposal seeks to identify downstream molecules which are more tractable from a drug development perspective. ..
  15. Receptor Tyrosine Kinase Sorting and Transactivation in Endosomes
    MARK LINDSAY GRIMES; Fiscal Year: 2010
    ..These studies are also relevant to the use of stem cells for nerve regeneration. ..
  16. Susan E Waltz; Fiscal Year: 2016
    ..The focus of this proposal is to define the role of a novel protein, termed Ron, and Ron- dependent signaling pathways as potential new therapeutic targets to combat this disease. ..
  17. DEVELOPMENT OF CANCER IMAGING AGENTS
    Henry VanBrocklin; Fiscal Year: 2000
    ..Additionally, it will provide inroads into new areas of research in drug discovery and therapeutic intervention. ..
  18. Quantitative Analysis of RET Receptor Activation and Signaling
    Adrian Whitty; Fiscal Year: 2013
    ..abstract_text> ..
  19. Role of Paxillin in Lung Cancer
    Ravi Salgia; Fiscal Year: 2012
    ..Our goal is to study the role of paxillin in lung cancer and ultimately arrive at novel therapy against this difficult disease. ..
  20. Ack1: Activation and Consequences in Prostate Cancer
    HENRY SHELTON EARP; Fiscal Year: 2012
    ..This proposal has the potential to yield significant new information about how Ack1 promotes prostate cancer progression and may lead to novel ways of treating prostate cancer patients by targeting Ack1 tyrosine kinase with new drugs. ..
  21. Goutam Ghosh Choudhury; Fiscal Year: 2016
    ....
  22. Mechanisms of BDNF and Glucocorticoid Action
    Michael J Garabedian; Fiscal Year: 2013
    ..abstract_text> ..
  23. Lecia V Sequist; Fiscal Year: 2016
    ..In this grant proposal, we aim to identify how these cancers become resistant so that we can design effective therapies to overcome this resistance and provide benefit to our patients. ..
  24. Wenqin Luo; Fiscal Year: 2016
    ..Results from this research will greatly improve our understanding of how mammalian mechanoreceptors develop and provide insight into axonal regeneration after injuries. ..
  25. Copolymer hydrogel microspheres for analysis of kinase activity in cell lysates
    Sean P Palecek; Fiscal Year: 2010
    ..This assay will likely be more rapid and less expensive than current methods, and have the advantage of predicting response to drug treatment. ..
  26. HERVE F AGAISSE; Fiscal Year: 2014
    ..These exploratory studies may provide mechanistic insight into molecular and cellular processes relevant to the treatment and prevention of diseases caused by pathogens that exploit the actin cytoskeleton for their dissemination. ..
  27. Norbert Perrimon; Fiscal Year: 2014
    ..The success of this application will provide a benchmark for reconstructing signaling networks on a global scale. ..
  28. Regulation of Endothelial Cell Function by Sprouty
    Robert E Friesel; Fiscal Year: 2010
    ..Our goal is to study these pathways at the cellular, molecular and genetic level to increase our knowledge to enable the development new treatments for cardiovascular disease. ..
  29. SIGNALING BY MUSK, A COMPONENT OF THE AGRIN RECEPTOR
    STEVEN BURDEN; Fiscal Year: 2012
    Our failure to understand how Agrin stimulates MuSK tyrosine phosphorylation is perhaps the most fundamental and glaring gap in our understanding of signaling at the neuromuscular synapse...
  30. The role of serine phosphorylation of IRS-2 in hepatic insulin resistance
    Xiao Sun; Fiscal Year: 2009
    ..The results from this investigation should provide a clearer, integrative understanding of the molecular determinants of insulin sensitivity in the liver as well as the whole organism. ..
  31. GERTRUD M SCHUPBACH; Fiscal Year: 2016
    ..Our work identifies further genes that act in the same pathway as the receptor and these genes will provide new targets for specific cancer drugs as well as allowing us to address side effects of available cancer drugs. ..
  32. Gadiparthi N Rao; Fiscal Year: 2016
    ....
  33. Fu Shin X Yu; Fiscal Year: 2016
    ....
  34. Targeting RON Receptor Signaling in Pancreatic Cancer
    Andrew M Lowy; Fiscal Year: 2010
    ..In this proposal, we will examine the effects of blocking RON receptor function by two different methods in order to determine if this can reverse pancreatic cancer growth alone and in combination with chemotherapy. ..
  35. Novel Estrogen Receptor Phosphorylation Sites in Sensitivity/Resistance to SERMs
    Christopher Williams; Fiscal Year: 2011
    ..Furthermore these studies may lead to improved therapeutic regimens for breast cancer patients, by targeting kinases associated with resistance. ..
  36. Jia Luo; Fiscal Year: 2016
    ..Understanding the interactions among alcohol, ErbB2 and MUC1 will also provide an important insight into the pathogenesis of some human diseases related to alcohol abuse as well as alcohol's teratogenic effect during development. ..
  37. Role of Cytokine Signaling in Intestinal Restitution
    Narendra Kumar; Fiscal Year: 2013
    ....
  38. Gangjian Qin; Fiscal Year: 2015
    ....
  39. An allosteric inhibitor of ZAP-70 as a novel therapeutic for autoimmune disease
    Arthur Weiss; Fiscal Year: 2010
    ....
  40. Modulation of ErbB Receptor Tyrosine Kinase Signaling
    Kermit L Carraway; Fiscal Year: 2011
    ..Specific Aim 2 examines the molecular mechanisms by which Muc4 alters receptor trafficking and localization. ..
  41. Barry M Gumbiner; Fiscal Year: 2014
    ..Findings from these studies should reveal how contact inhibition regulates normal tissue development and how the loss of contact inhibition leads to the formation and progression of tumors. ..
  42. STEVEN BURDEN; Fiscal Year: 2015
    The Agrin/Lrp4/MuSK/Dok-7 signal transduction cascade is critical for synaptogenesis. Binding between Agrin and Lrp4 stimulates tyrosine phosphorylation of MuSK and recruitment and tyrosine phosphorylation of Dok-7...
  43. Carol B Post; Fiscal Year: 2016
    ..The proposed research aims to elucidate mechanisms of this control for Syk and Src PTKs with the goal of contributing new knowledge that is useful in fighting human disease. ..
  44. Design of novel c-Met inhibitors inspired by olive phenolics
    Khalid A El Sayed; Fiscal Year: 2013
    ..Anticipated new information will facilitate important therapeutic advances for alleviation and prevention of c-Met dependent malignancies. ..
  45. Pasi A Janne; Fiscal Year: 2016
    ..Findings from these studies have therapeutic implications for patients with cancers harboring genomic alterations in RET and catalyze the development of clinical trials for such patients. ..
  46. Regulation of EGFR Signaling by the Endocytic Pathway
    Brian P Ceresa; Fiscal Year: 2013
    ..The immediate goal of this research is to better understand the molecular mechanisms that regulate the biological and pathological functions of the EGFR and use that information for treatment of diseases associated with the EGFR. ..
  47. Forest M White; Fiscal Year: 2015
    ..The proposed studies use innovative experimental approaches to reveal new mechanistic insights necessary for building more powerful and accurate models. ..
  48. ARTHUR ROBERT SALOMON; Fiscal Year: 2014
    ..Testing of a newly postulated, phosphoproteomic data-inspired hypothesis about the Zap-70 dependent regulation of Fyn kinase through PTPa will be explored with classical molecular approaches. ..
  49. LINDA JOY PIKE; Fiscal Year: 2015
    ..These studies will provide a more accurate and comprehensive foundation upon which to base research strategies and clinical choices for the development and utilization of ErbB-targeted therapeutics. ..
  50. Jessica E Treisman; Fiscal Year: 2016
    ..Taken together, the proposal will reveal new molecular mechanisms in a conserved signaling pathway that is critical for retinal development. ..
  51. Receptor Tyrosine Kinase Signaling Networks
    Joannes B Hoek; Fiscal Year: 2010
    ....
  52. Advanced Anatomic and Functional Response Assessment in Lung Cancer
    Lawrence H Schwartz; Fiscal Year: 2011
    ..3. To determine if the use of a continuous scale best overall response better predicts than the categorical response assessment currently used. ..
  53. Ron Bose; Fiscal Year: 2016
    ..This information will identify new patients who are likely to benefit from Her2 targeted drugs and will provide the key scientific findings to support a future breast cancer clinical trial. ..
  54. Matthew L Meyerson; Fiscal Year: 2016
    ....
  55. Epidermal growth factor receptor signaling in glioma
    Joon Uhm; Fiscal Year: 2006
    ..abstract_text> ..
  56. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
    ..muscle fiber membrane receptor complex consisting of LRP4, a low-density lipoprotein receptor-related protein, and MuSK, a muscle-specific tyrosine kinase...
  57. Subhash C Pandey; Fiscal Year: 2016
    ....
  58. Anti-Fibrotic Therapy for Scleroderma/SSc
    Latha Paka; Fiscal Year: 2010
    ..The objective of this application is to evaluate a lead small- molecule drug candidate in two preclinical models of scleroderma/SSc to advance to SBIR Phase-II project with the ultimate objective of bringing our drug to clinical trials. ..
  59. EXPRESSION PROFILES FOR RET-POSITIVE DRG NEURONS
    Sanjay Jain; Fiscal Year: 2013
    ..Interactions with members of other GUDMAP projects and the community will provide synergies that will accelerate discovery and mechanism based projects related to pelvic visceral sensory system. ..
  60. REGULATION OF NMDA RECEPTOR CLUSTERING BY EPH KINASES
    Mustafa Sahin; Fiscal Year: 2004
    ..of the cholinergic receptors is induced by a proteoglycan (agrin), which activates a receptor tyrosine kinase (MuSK)...
  61. Hypertension and Collagen: Effect of Ac-SDKP
    Nour Eddine Rhaleb; Fiscal Year: 2010
    ..Consequently, it will identify another component (Ac-SDKP) as part of the multiple mediators participating in the cardioprotective effects of ACEi in hypertension. ..
  62. Ephrin-A3 in Neuron-Glia Communication
    Elena B Pasquale; Fiscal Year: 2011
    ..Strategies to manipulate ephrin function in glial cells could help treatment of neurological disorders involving aberrant neuron-glia interactions in the hippocampus and other regions of the nervous system. ..
  63. Optimization of EphA4 antagonists for CNS disorders
    ELENA B contact PASQUALE; Fiscal Year: 2010
    ..The optimized antagonists will be useful to further study the physiological and pathological functions of EphA4 and may serve as starting points for drug development to treat disorders of the nervous system. ..
  64. CONTROL OF SYNAPTOGENESIS IN HUMAN SKELETAL MUSCLE
    Michael King; Fiscal Year: 1999
    ..The roles of recently discovered muscle specific kinase, MuSK, and its activator, nerve-derived factor agrin, reported to control many aspects of synaptogenesis, will be ..
  65. Wnt Signaling in Synaptic Prepattern formation and Motor Axon Guidance
    Laura R Gordon; Fiscal Year: 2011
    ..One key molecular player in the development of the neuromuscular junction is the transmembrane receptor unplugged/MuSK. Unplugged/MuSK is specifically expressed in muscle fibers and controls two aspects of neuromuscular junction ..
  66. C-FES PROTEIN-TYROSINE KINASE IN MYELOID DIFFERENTIATION
    Robert Glazer; Fiscal Year: 1993
    ..Cognizance of this regulatory process should aid in the design of differentiation- specific therapies for myeloid leukemias...
  67. NERVE-MUSCLE SYNAPSE ORGANIZING MOLECULES
    Justin Fallon; Fiscal Year: 2005
    ..The agrin signaling receptor MuSK is essential for this induction...
  68. Signal Amplification by an RTK/Abl Kinase Module
    Ann Marie Pendergast; Fiscal Year: 2007
    ..nerve secretes the glycoprotein agrin, which, in turn, activates the muscle-specific receptor tyrosine kinase (MUSK)...
  69. Structure-Function Studies of the Receptor Tyrosine Kinase MuSK
    STEVAN HUBBARD; Fiscal Year: 2009
    The neuromuscular junction (NMJ) is a highly specialized synapse whose formation is dependent on MuSK (muscle-specific kinase), a receptor tyrosine kinase that is activated by agrin, a heparan-sulfate proteoglycan derived from motor ..
  70. Analysis of the Novel Kinase ROR2: A New Molecular Target in Renal Cell Carcinoma
    Tricia M Wright; Fiscal Year: 2010
    ..The long term goal of this study is not only to analyze the importance of ROR2 in RCC but also to use the gained knowledge of ROR2 function in the hopes of finding inhibitors that can be used clinically for treating RCC. ..
  71. Role of receptor tyrosine kinase signaling in branching morphogenesis
    PENGFEI PAUL LU; Fiscal Year: 2010
    ..If deregulation of RTK signaling could be prevented then we would greatly improve therapeutic interventions of human congenital illnesses inflicting the above epithelial organs and save the lives of millions of patients. ..
  72. OSTEOCLASTIC PHOSPHOTYROSYL PHOSPHATASE AND RESORPTION
    KIN HING LAU; Fiscal Year: 2002
    ....