MUC5B

Summary

Gene Symbol: MUC5B
Description: mucin 5B, oligomeric mucus/gel-forming
Alias: MG1, MUC-5B, MUC5, MUC9, mucin-5B, cervical mucin MUC5B, high molecular weight salivary mucin MG1, mucin 5, subtype B, tracheobronchial, sublingual gland mucin
Species: human

Top Publications

  1. ncbi Characterization of mucins from cultured normal human tracheobronchial epithelial cells
    D J Thornton
    The Wellcome Trust Centre for Cell Matrix Research, Division of Biochemistry, School of Biological Sciences, University of Manchester, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 278:L1118-28. 2000
  2. ncbi Expression of membrane-bound mucins (MUC1 and MUC4) and secreted mucins (MUC2, MUC5AC, MUC5B, MUC6 and MUC7) in mucoepidermoid carcinomas of salivary glands
    Llucia Alos
    Department of Pathology, Hospital Clinic, IDIBAPS, University of Barcelona, Villaroel 170, 08036 Barcelona, Spain
    Am J Surg Pathol 29:806-13. 2005
  3. ncbi Large scale identification of proteins, mucins, and their O-glycosylation in the endocervical mucus during the menstrual cycle
    Ylva Andersch-Björkman
    Department of Medical Biochemistry, Goteborg University, 41390 Gothenburg, Sweden
    Mol Cell Proteomics 6:708-16. 2007
  4. ncbi The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse
    Kristina A Thomsson
    Department of Medical Biochemistry, Goteborg University, Medicinaregatan 9A, 413 90 Gothenburg, Sweden
    Glycobiology 12:1-14. 2002
  5. ncbi Structure and biosynthesis of human salivary mucins
    A Zalewska
    Department of Pharmaceutical Biochemistry Institute of Chemistry, Białystok, Poland
    Acta Biochim Pol 47:1067-79. 2000
  6. ncbi MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions
    Markus O Henke
    Department of Pulmonary Medicine, Philipps University Marburg, Germany
    Am J Respir Cell Mol Biol 31:86-91. 2004
  7. ncbi Promoter analysis and aberrant expression of the MUC5B gene in diffuse panbronchiolitis
    Koichiro Kamio
    Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Am J Respir Crit Care Med 171:949-57. 2005
  8. pmc The role of crude human saliva and purified salivary MUC5B and MUC7 mucins in the inhibition of Human Immunodeficiency Virus type 1 in an inhibition assay
    Habtom H Habte
    Department of Surgery, University of Cape Town, Cape Town, South Africa
    Virol J 3:99. 2006
  9. ncbi Upper airway mucin gene expression: a review
    Mahmoud S Ali
    Epithelial Group, Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, United Kingdom
    Laryngoscope 117:932-8. 2007
  10. ncbi Structure and function of the polymeric mucins in airways mucus
    David J Thornton
    Wellcome Trust Center for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Annu Rev Physiol 70:459-86. 2008

Research Grants

  1. Diego Preciado; Fiscal Year: 2015
  2. Regulation of MUC19 by Th2 cytokine in airway epithelium
    Yin Chen; Fiscal Year: 2011
  3. Christopher M Evans; Fiscal Year: 2016
  4. Mehmet Kesimer; Fiscal Year: 2014
  5. Mehmet Kesimer; Fiscal Year: 2014
  6. Prenatal Bisphenol A and Lung Maturation
    Laura S Van Winkle; Fiscal Year: 2013
  7. IMMUNOCHEMISTRY OF SALIVARY MUCINS IN DENTAL DISEASE
    Robert Cohen; Fiscal Year: 1992
  8. MUCIN AND NON-MUCIN PROTEINS IN GALLSTONE PATHOGENESIS
    Gwynneth Offner; Fiscal Year: 2000
  9. MUC19, a novel gel-forming mucin in salivary glands
    Yin Chen; Fiscal Year: 2005
  10. COLON CELL DIFFERENTIATION--DCC ROLE IN MUC2 EXPRESSION
    Leonard Augenlicht; Fiscal Year: 2000

Detail Information

Publications232 found, 100 shown here

  1. ncbi Characterization of mucins from cultured normal human tracheobronchial epithelial cells
    D J Thornton
    The Wellcome Trust Centre for Cell Matrix Research, Division of Biochemistry, School of Biological Sciences, University of Manchester, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 278:L1118-28. 2000
    ..epithelium over a 2- to 3-wk period and express increasing mRNA levels of the airway mucin genes MUC5AC and MUC5B as the cultures age; the levels of MUC2 mRNA were very low throughout the study...
  2. ncbi Expression of membrane-bound mucins (MUC1 and MUC4) and secreted mucins (MUC2, MUC5AC, MUC5B, MUC6 and MUC7) in mucoepidermoid carcinomas of salivary glands
    Llucia Alos
    Department of Pathology, Hospital Clinic, IDIBAPS, University of Barcelona, Villaroel 170, 08036 Barcelona, Spain
    Am J Surg Pathol 29:806-13. 2005
    ..Normal salivary glands frequently expressed MUC1 and MUC4, mainly in ductal cells; MUC5B and MUC7 stained mucous and serous acini respectively of submandibular and minor salivary glands; and MUC5AC and ..
  3. ncbi Large scale identification of proteins, mucins, and their O-glycosylation in the endocervical mucus during the menstrual cycle
    Ylva Andersch-Björkman
    Department of Medical Biochemistry, Goteborg University, 41390 Gothenburg, Sweden
    Mol Cell Proteomics 6:708-16. 2007
    ..Three gel-forming (MUC5B, MUC5AC, and MUC6) and two transmembrane mucins (MUC16 and MUC1) were identified...
  4. ncbi The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse
    Kristina A Thomsson
    Department of Medical Biochemistry, Goteborg University, Medicinaregatan 9A, 413 90 Gothenburg, Sweden
    Glycobiology 12:1-14. 2002
    ..The presence of MUC5B as the major mucin in this preparation was confirmed by amino acid analysis and its reactivity with the monoclonal ..
  5. ncbi Structure and biosynthesis of human salivary mucins
    A Zalewska
    Department of Pharmaceutical Biochemistry Institute of Chemistry, Białystok, Poland
    Acta Biochim Pol 47:1067-79. 2000
    Human salivary glands secrete two types of mucins: oligomeric mucin (MG1) with molecular mass above 1 MDa and monomeric mucin (MG2) with molecular mass of 200-250 kDa...
  6. ncbi MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions
    Markus O Henke
    Department of Pulmonary Medicine, Philipps University Marburg, Germany
    Am J Respir Cell Mol Biol 31:86-91. 2004
    ..part to mucus hypersecretion, there are no published data showing an increase in the gel-forming mucins MUC5AC or MUC5B in CF secretions...
  7. ncbi Promoter analysis and aberrant expression of the MUC5B gene in diffuse panbronchiolitis
    Koichiro Kamio
    Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, 1 21 1 Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Am J Respir Crit Care Med 171:949-57. 2005
    ..We analyzed nucleotide sequences of regulatory region of six mucin genes--MUC1, MUC2, MUC4, MUC5AC, MUC5B, and MUC7--and detected their promoter polymorphisms...
  8. pmc The role of crude human saliva and purified salivary MUC5B and MUC7 mucins in the inhibition of Human Immunodeficiency Virus type 1 in an inhibition assay
    Habtom H Habte
    Department of Surgery, University of Cape Town, Cape Town, South Africa
    Virol J 3:99. 2006
    ..The purpose of this study was to purify salivary MUC5B and MUC7 mucins from crude saliva and determine their anti-HIV-1 activities.
  9. ncbi Upper airway mucin gene expression: a review
    Mahmoud S Ali
    Epithelial Group, Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, United Kingdom
    Laryngoscope 117:932-8. 2007
    ..The protein backbones of mucins are encoded by mucin genes. Of the currently known 20 mucin genes that encode protein backbone of mucins, 16 have been identified in the airways...
  10. ncbi Structure and function of the polymeric mucins in airways mucus
    David J Thornton
    Wellcome Trust Center for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Annu Rev Physiol 70:459-86. 2008
    ..In normal physiology, the secreted mucins, in particular the polymeric mucins MUC5AC and MUC5B, provide the organizing framework of the airways mucus gel and are major contributors to its rheological ..
  11. pmc Hyaluronan fragments/CD44 mediate oxidative stress-induced MUC5B up-regulation in airway epithelium
    S Marina Casalino-Matsuda
    Division of Pulmonary and Critical Care Medicine R 47, University of Miami, Miller School of Medicine, 1600 NW 10th Ave, RMSB 7072A, Miami, FL 33136, USA
    Am J Respir Cell Mol Biol 40:277-85. 2009
    Mucus hypersecretion with elevated MUC5B mucin production is a pathologic feature in many airway diseases associated with oxidative stress...
  12. pmc MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease
    Sara Kirkham
    1Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Am J Respir Crit Care Med 178:1033-9. 2008
    ..Therefore, we hypothesized that the polymeric mucin composition or properties may be different in the sputum from individuals with COPD and smokers without airflow obstruction...
  13. doi Leptin up-regulates MUC5B expression in human airway epithelial cells via mitogen-activated protein kinase pathway
    Hyun Jae Woo
    Department of Otorhinolaryngology Head and Neck Surgery, Gumi CHA Hospital, CHA University, Gumi, Republic of Korea
    Exp Lung Res 36:262-9. 2010
    ..Treatment with leptin significantly increased the expression of MUC5AC and MUC5B in NCI-H292 cells; these effects were blocked by mutant leptin...
  14. doi Protein and mucin retention on oral mucosal surfaces in dry mouth patients
    Rashida Pramanik
    NIHR Biomedical Research Centre and KCL Salivary Research Unit, Kings College London and Guy s and St Thomas NHS, Guy sCampus, London, UK
    Eur J Oral Sci 118:245-53. 2010
    ..High-molecular-weight mucin (MUC5B) was present in greater amounts on the anterior tongue than on other surfaces in control subjects...
  15. pmc Anti-HIV-1 activity of salivary MUC5B and MUC7 mucins from HIV patients with different CD4 counts
    Habtom H Habte
    Department of Surgery, Division of General Surgery, University of Cape Town, Observatory, Cape 7925, South Africa
    Virol J 7:269. 2010
    We have previously shown that MUC5B and MUC7 mucins from saliva of HIV negative individuals inhibit HIV-1 activity by 100% in an in vitro assay...
  16. pmc A common MUC5B promoter polymorphism and pulmonary fibrosis
    Max A Seibold
    National Jewish Health, Denver, USA
    N Engl J Med 364:1503-12. 2011
    ..The mutations that have been implicated in pulmonary fibrosis account for only a small proportion of the population risk...
  17. pmc The pulmonary fibrosis-associated MUC5B promoter polymorphism does not influence the development of interstitial pneumonia in systemic sclerosis
    Anna L Peljto
    School of Public Health, University of Colorado Denver, Aurora, CO 80045, USA
    Chest 142:1584-8. 2012
    ..We recently identified a common variant in the promoter region of MUC5B (rs35705950) that has a significant effect on the risk of developing both familial and sporadic forms of IP...
  18. doi Mucin5B expression by lung alveolar macrophages is increased in long-term smokers
    Ruth Sepper
    Institute of Clinical Medicine, Tallinn University of Technology, Tallinn, Estonia
    J Leukoc Biol 92:319-24. 2012
    This study investigated the expression of MUC5B by AMs in the lungs of cigarette smokers and nonsmokers...
  19. doi The genetic and environmental causes of pulmonary fibrosis
    Ken Macneal
    University of Colorado, 12631 East 17th Avenue, Aurora, CO 80045, USA
    Proc Am Thorac Soc 9:120-5. 2012
    ..and environmental causes of pulmonary fibrosis, specifically focusing on genetic and epigenetic variants of MUC5B and several types of ILD, to discuss why only some individuals with the MUC5B promoter polymorphism develop ..
  20. doi Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis
    Carmel J Stock
    Interstitial Lung Disease Unit, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London, London, UK
    Thorax 68:436-41. 2013
    A polymorphism (rs35705950) 3 kb upstream of MUC5B, the gene encoding Mucin 5 subtype B, has been shown to be associated with familial and sporadic idiopathic pulmonary fibrosis (IPF)...
  21. pmc The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium
    Max A Seibold
    Center for Genes, Environment and Health, National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 8:e58658. 2013
    We previously identified a MUC5B gene promoter-variant that is a risk allele for sporadic and familial Idiopathic Pulmonary Fibrosis/Usual Interstitial Pneumonia (IPF/UIP)...
  22. pmc Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis
    Anna L Peljto
    Department of Epidemiology, School of Public Health, University of Colorado Denver, USA
    JAMA 309:2232-9. 2013
    ..In addition to the potential for improving prognostic models, identifying genetic and molecular features that are associated with IPF mortality may provide insight into the underlying mechanisms of disease and inform clinical trials...
  23. pmc The MUC5B variant is associated with idiopathic pulmonary fibrosis but not with systemic sclerosis interstitial lung disease in the European Caucasian population
    Raphael Borie
    Service de Pneumologie A, APHP, Hopital Bichat, Paris, France
    PLoS ONE 8:e70621. 2013
    A polymorphism on the MUC5B promoter (rs35705950) has been associated with idiopathic pulmonary fibrosis (IPF) but not with systemic sclerosis (SSc) with interstitial lung disease (ILD)...
  24. pmc Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study
    Imre Noth
    Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, USA Electronic address
    Lancet Respir Med 1:309-17. 2013
    ..Several rare genetic variants and one common single nucleotide polymorphism (SNP) of MUC5B have been associated with the disease...
  25. pmc A morphometric study of mucins and small airway plugging in cystic fibrosis
    Pierre Regis Burgel
    Service de Pneumologie, Hopital Cochin, Universite Rene Descartes, 27 rue du Faubourg St Jacques, 75 679 Paris Cedex 14, France
    Thorax 62:153-61. 2007
    ..Little knowledge exists on structural changes and plugging in small airways in cystic fibrosis...
  26. ncbi Evidence that gallbladder epithelial mucin enhances cholesterol cholelithogenesis in MUC1 transgenic mice
    Helen H Wang
    Department of Medicine, Liver Center and Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School and Harvard Digestive Diseases Center, Boston, Massachusetts 02215, USA
    Gastroenterology 131:210-22. 2006
    ..The gel-forming mucins play an important role in the early stage of cholesterol gallstone formation. We investigated whether the gallbladder epithelial mucin encoded by mucin gene 1 (MUC1) influences susceptibility to gallstones...
  27. pmc Sequence of the 5'-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells
    I Van Seuningen
    Unite INSERM 377, Place de Verdun, 59045 Lille Cedex, France
    Biochem J 348:675-86. 2000
    ..5 human mucin gene cluster, we have characterized 3.55 kb of the 5'-flanking region of the human mucin gene MUC5B, including the promoter, the first two exons and the first intron...
  28. ncbi Normal respiratory mucosa, precursor lesions and lung carcinomas: differential expression of human mucin genes
    M C Copin
    Laboratoire de Biochimie et Biologie Moleculaire, Hopital C Huriez CHRU Lille, France, Faculte de Medecine, Universite de Lille II, Lille, France
    Front Biosci 6:D1264-75. 2001
    ..Eight human mucin genes have been well characterized: MUC2, MUC5AC, MUC5B, MUC6 map to 11p15...
  29. doi Proteomic analysis of polymeric salivary mucins: no evidence for MUC19 in human saliva
    Karine Rousseau
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, The Michael Smith Building, University of Manchester, Manchester M13 9PT, UK
    Biochem J 413:545-52. 2008
    b>MUC5B is the predominant polymeric mucin in human saliva [Thornton, Khan, Mehrotra, Howard, Veerman, Packer and Sheehan (1999) Glycobiology 9, 293-302], where it contributes to oral cavity hydration and protection...
  30. ncbi Model systems for investigating mucin gene expression in airway diseases
    M C Rose
    Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    J Aerosol Med 13:245-61. 2000
    ..Several inflammatory mediators have now been shown to regulate expression of MUC2, MUC5AC, and MUC5B genes. Importantly, mucin gene expression can be regulated both transcriptionally and posttranscriptionally...
  31. ncbi Mucins of the human endocervix
    I K Gipson
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
    Front Biosci 6:D1245-55. 2001
    ..mRNA levels of the gel-forming mucin MUC5B, the major gel-forming mucin expressed by the endocervical epithelium, peak before midcycle and the amount of ..
  32. ncbi Up-regulation of mucin secretion in HT29-MTX cells by the pro-inflammatory cytokines tumor necrosis factor-alpha and interleukin-6
    M G Smirnova
    Department of Physiological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Eur Cytokine Netw 12:119-25. 2001
    ..The MUC5AC and MUC5B mucin gene products have been identified as components of these effusions...
  33. ncbi Sulphation of the salivary mucin MG1 (MUC-5B) is not correlated to the degree of its sialylation and is unaffected by cystic fibrosis
    D K Shori
    Department of Oral Pathology, Rayne Institute, King s College, 123 Coldharbour Lane, London SE5 9NU, UK
    Pflugers Arch 443:S50-4. 2001
    ..To test this hypothesis we compared expression of sulphate and sialic acid on three salivary mucins namely MG1 (MUC-5B), MG2 (MUC-7) and GL...
  34. ncbi The structure of complement C3b provides insights into complement activation and regulation
    A Abdul Ajees
    Center for Biophysical Sciences and Engineering, 1530 3rd Avenue South, Birmingham, Alabama 35294, USA
    Nature 444:221-5. 2006
    ..derived from the proteolysis of C3b, have revealed a domain configuration, including six macroglobulin domains (MG1-MG6; nomenclature follows ref. 5) arranged in a ring, termed the beta-ring...
  35. pmc An inventory of mucin genes in the chicken genome shows that the mucin domain of Muc13 is encoded by multiple exons and that ovomucin is part of a locus of related gel-forming mucins
    Tiange Lang
    Department of Medical Biochemistry, Goteborg University, Goteborg, Sweden
    BMC Genomics 7:197. 2006
    ..Using such methods we are able to characterize different organisms where genome sequence is available with respect to their mucin repertoire...
  36. doi Induced sputum concentrations of mucin in patients with asthma and chronic cough
    Makiko Jinnai
    Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Shogoin, Sakyoku, Kyoto 606 8507, Japan
    Chest 137:1122-9. 2010
    ..Mucus hypersecretion is an important pathophysiologic index of airway disease. Measurement of secreted mucin in sputum has been reported in asthma, but not in chronic cough with or without increased sputum production...
  37. doi Mucin biosynthesis in the bovine goblet cell induced by Cooperia oncophora infection
    Robert W Li
    Bovine Functional Genomics Laboratory, Animal and Natural Resources Institute, USDA ARS, Beltsville, MD 20705, USA
    Vet Parasitol 165:281-9. 2009
    ..b>MUC5B expression at the mRNA level was also higher in lamina propria at 28dpi...
  38. pmc Physical characterization of the MUC5AC mucin: a highly oligomeric glycoprotein whether isolated from cell culture or in vivo from respiratory mucous secretions
    J K Sheehan
    The Wellcome Trust Centre for Cell Matrix Research, Division of Biochemistry, School of Biological Sciences, 2 205, Stopford Building, University of Manchester, Manchester M13 9PT, U K
    Biochem J 347:37-44. 2000
    ..Similar antisera raised against the MUC2 and MUC5B mucins were not reactive...
  39. pmc Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa
    R J Longman
    University Department of Surgery, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Gut 47:792-800. 2000
    ..We tested the hypothesis that individual trefoil peptides are uniquely localised with specific mucins in the UACL and normal gastrointestinal epithelia...
  40. ncbi Mucin gene transcripts in benign and borderline mucinous tumours of the ovary: an in situ hybridization study
    F Boman
    Pathology, Calmette Hospital, Lille, France
    J Pathol 193:339-44. 2001
    ..The purpose of this study was to evaluate the expression of mucin genes (MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6) in ovarian mucinous tumour cells, to relate MUC gene expression to the histological diagnosis, and to ..
  41. ncbi Pattern changes of mucin gene expression with pneumococcal otitis media
    Y Tsuboi
    Otitis Media Research Center, Department of Otolaryngology, School of Medicine, University of Minnesota, 2001 Sixth Street S E, Rm 216, Minneapolis, MN 55455, USA
    Int J Pediatr Otorhinolaryngol 61:23-30. 2001
    ..The purpose of this study was to characterize mucin gene expression in middle ears and Eustachian tubes with pneumococcal ear infection...
  42. pmc The characterisation of mucin in a mature ovarian teratoma occurring in an eight year old patient
    Anwar Suleman Mall
    Departments of Surgery, Groote Schuur and Red Cross Hospitals, University of Cape Town, Cape Town, South Africa
    Int J Med Sci 4:115-23. 2007
    ..The presence of MUC5AC (M1 antigen) and MUC6 have previously been found in ovarian mucinous cyst. We characterized the mucins in the crude mucus and tissue of a mature ovarian teratoma in an 8 year old girl...
  43. ncbi Organization and regulatory aspects of the human intestinal mucin gene (MUC2) locus
    A Velcich
    Department of Oncology, Montefiore Medical Center Albert Einstein Cancer Center, Bronx, New York 10467, USA
    J Biol Chem 272:7968-76. 1997
    ..orientation to that of MUC2, is expressed with a pattern distinct from that of MUC2, yet similar to that of MUC5B and MUC6, two additional mucin genes located at chromosome 11p15...
  44. doi Potential use of mucins as biomaterial coatings. II. Mucin coatings affect the conformation and neutrophil-activating properties of adsorbed host proteins--toward a mucosal mimic
    Tomas Sandberg
    Division of Surface Biotechnology, Department of Physical and Analytical Chemistry, BMC, Uppsala University, Uppsala SE 751 23, Sweden
    J Biomed Mater Res A 91:773-85. 2009
    ..and characterization study on mucins of bovine salivary (BSM), porcine gastric (PGM), and human salivary (MG1) origin, this study evaluates the effect of mucin precoating on the conformation and neutrophil-activating ..
  45. ncbi Immunohistochemical detection of gastric mucin in normal and disease states
    K L Taylor
    Department of Anatomical Pathology, University of Cape Town, South Africa
    Oncol Res 10:465-73. 1998
    ..Diffuse adenocarcinomas showed strong positive MUC2 and 6 staining, and in some cases MUC5 and 7. In conclusion, we have shown different patterns of mucin immunoreactivity in various gastric disease states...
  46. ncbi Mucins and mucin binding proteins in colorectal cancer
    James C Byrd
    The Department of Gastrointestinal Medicine and Nutrition, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 436 Houston, TX 77030, USA
    Cancer Metastasis Rev 23:77-99. 2004
    ..There are two structurally and functionally distinct classes of mucins: secreted gel-forming mucins (MUC2, MUC5AC, MUC5B, and MUC6) and transmembrane mucins (MUC1, MUC3A, MUC3B, MUC4, MUC12, MUC17), although the products of some MUC ..
  47. doi Protein signatures (molecular synapomorphies) that are distinctive characteristics of the major cyanobacterial clades
    Radhey S Gupta
    Department of Biochemistry, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Int J Syst Evol Microbiol 59:2510-26. 2009
    ..12 aa insert in Pol I, 3 aa insert in RpoB, 2 aa insert in KgsA, 6 aa insert in TyrRS, 2 aa insert in tRNA-mG1 transferase and 1 aa deletion in the RpoC protein); a clade of the low-B/A ecotype Prochlorococcus strains (5 aa ..
  48. pmc Assay of mucins in human tear fluid
    Sandra Spurr-Michaud
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Exp Eye Res 84:939-50. 2007
    Mucin genes, both secreted (MUC2, MUC5AC, MUC5B, MUC7) and membrane associated (MUC1, MUC4, MUC16), have been reported to be expressed by ocular surface epithelia...
  49. ncbi Allelic association and recombination hotspots in the mucin gene (MUC) complex on chromosome 11p15.5
    K Rousseau
    The Galton Laboratory, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK
    Ann Hum Genet 71:561-9. 2007
    ..5; tel MUC6-MUC2-MUC5AC-MUC5B cen; approx. 400 kb)...
  50. ncbi Structure, function and gene expression of epithelial mucins
    E Seregni
    Nuclear Medicine Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan
    Tumori 83:625-32. 1997
    ..biochemical studies, it is now possible to identify eight apomucin genes, namely MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6 and MUC7...
  51. ncbi MUC4 and MUC5B transcripts are the prevalent mucin messenger ribonucleic acids of the human endocervix
    I K Gipson
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Reprod 60:58-64. 1999
    ..polymerase chain reaction analyses indicated that the principal mucin transcripts of human endocervix are MUC4 and MUC5B, with MUC4 predominant in 15 of 21 samples...
  52. ncbi Mucin apoprotein expression in COPD
    George D Leikauf
    Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Chest 121:166S-182S. 2002
    ..lung include MUC2 (in cells with and without secretory granules), MUC5AC (in surface and submucosal mucous cells), MUC5B and MUC8 (in submucosal mucous cells), and MUC7 (in submucosal serous cells)...
  53. ncbi Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1beta in human bronchial epithelia
    Thomas Gray
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Physiol Lung Cell Mol Physiol 286:L320-30. 2004
    ..Fully differentiated NHTBE cultures secreted two major airway mucins, MUC5AC and MUC5B. IL-1beta, in a dose- and time-dependent manner, increased the secretion of MUC5AC, but not MUC5B...
  54. pmc Dietary n-3 fatty acids have suppressive effects on mucin upregulation in mice infected with Pseudomonas aeruginosa
    Daniel Tetaert
    INSERM, U837, JPARC Research Centre, IMPRT, Place de Verdun, Lille, France
    Respir Res 8:39. 2007
    ..This suggests that n-3 PUFAs may have a protective effect against mucus over-production in airway diseases. Therefore, we hypothesized that n-3 PUFAs may downregulate mucins expression...
  55. ncbi Increased expression of mucin 5AC mRNA and decreased expression of epidermal growth-factor receptor mRNA in gallstone patients
    Hyo Jung Kim
    Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea
    Tohoku J Exp Med 214:139-44. 2008
    ..Several mucin genes (MUC) have been implicated in various diseases and gel-forming mucin genes (MUC2, MUC5AC, MUC5B, and MUC6) were recognized to be the important components of digestive mucus...
  56. ncbi Mucins and mucin-associated carbohydrate antigens expression in gastric carcinoma cell lines
    F Carvalho
    Institute of Molecular Pathology and Immunology of the University of Porto, IPATIMUP, Rua Dr Roberto Frias s n, 4200 Porto, Portugal
    Virchows Arch 435:479-85. 1999
    ..of mucin expression observed in human gastric carcinomas with occasional expression of MUC2, MUC3, MUC4 and MUC5B; (c) does not include, at least in our series, the expression of MUC6 mucin; and (d) follows in part the ..
  57. pmc Mucin gene expression in Barrett's oesophagus: an in situ hybridisation and immunohistochemical study
    G S Arul
    Department of Paediatric Surgery, Bristol Royal Infirmary, Bristol, UK
    Gut 47:753-61. 2000
    ..Little is known about the expression pattern in the oesophagus. In this study we have investigated MUC gene expression in both the normal oesophagus and specialised intestinal metaplasia (Barrett's oesophagus)...
  58. ncbi [Normal human conjunctival epithelium expresses MUC13, MUC15, MUC16 and MUC17 mucin genes]
    R M Corrales
    Instituto Universitario de Oftalmobiologia Aplicada IOBA, Universidad de Valladolid, Valladolid, Espana
    Arch Soc Esp Oftalmol 78:375-81. 2003
    ..This study was designed to determine the expression profile of mucin genes in conjunctival impression cytology (CIC) samples from healthy subjects...
  59. doi Helicobacter spp. other than Helicobacter pylori
    Arinze S Okoli
    School of Medicine, Sydney, The University of Notre Dame Australia, 160 Oxford St, Darlinghurst, NSW 2010, Australia
    Helicobacter 14:69-74. 2009
    ..support an association between Helicobacter heilmannii and gastric adenocarcinoma; and in mice, mucins MUC4 and MUC5 but not MUC1 influence the colonization and pathogenesis of Helicobacter felis...
  60. pmc Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?
    V Guyonnet Duperat
    Unité INSERM N 377, Lille, France
    Biochem J 305:211-9. 1995
    ..The data suggest that MUC5A and MUC5C are part of the same gene (called MUC5AC) which is distinct from MUC5B. In the second part of this work, complete sequences of the inserts corresponding to previously described (JER47, ..
  61. ncbi Molecular characterization of a major high molecular weight mucin from human sublingual gland
    R F Troxler
    Department of Biochemistry, Boston University Medical Center, MA 02118, USA
    Glycobiology 7:965-73. 1997
    ..a series of probes for tandem repeats found in the high molecular weight secreted mucins MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6...
  62. pmc Physical characterization of a low-charge glycoform of the MUC5B mucin comprising the gel-phase of an asthmatic respiratory mucous plug
    J K Sheehan
    Wellcome Trust Centre for Cell Matrix Research, University of Manchester, School of Biological Sciences, 2 205, Stopford Building, Manchester M13 9PT, UK
    Biochem J 338:507-13. 1999
    ..Here we show that this mucin fraction is dominated (at least 96% of the total) by the low-charge glycoform of the MUC5B gene product...
  63. ncbi Structural differences in the drone olfactory system of two phylogenetically distant Apis species, A. florea and A. mellifera
    A Brockmann
    Institut für Verhaltensphysiologie und Soziobiologie, Theodor Boveri Institut für Biowissenschaften, Universitat Wurzburg, 97074 Wurzburg, Germany
    Naturwissenschaften 88:78-81. 2001
    ..each equipped with receptor neurons sensitive to the queen's sex pheromone, and four voluminous macroglomeruli (MG1-MG4) in the antennal lobes...
  64. ncbi Megaesophagus microbiota: a qualitative and quantitative analysis
    Denis Pajecki
    Department of Gastrointestinal Surgery, University of Sao Paulo School of Medicine, Brazil
    J Gastrointest Surg 6:723-9. 2002
    ..were divided into three subgroups (n = 5 patients in each) according to the grade of esophageal dilation: MG1 = megaesophagus grade I; MG2 = megaesophagus grade II; and MG3 = megaesophagus grade III...
  65. ncbi Proteins in whole saliva during the first year of infancy
    S Ruhl
    Department of Operative Dentistry and Periodontology, Dental School, University of Regensburg, D 93042 Regensburg, Germany
    J Dent Res 84:29-34. 2005
    ..Exceptions were the mucins and albumin. The mucins are expressed differentially, with first MUC7 and later MUC5B being predominant. Albumin, a marker of serum leakage, started to rise in whole saliva preceding tooth eruption...
  66. ncbi Absence of CFTR is associated with pleiotropic effects on mucins in mouse gallbladder epithelial cells
    Rahul Kuver
    Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Am J Physiol Gastrointest Liver Physiol 291:G1148-54. 2006
    ..Muc1, Muc3, Muc4, Muc5ac, and Muc5b mRNA levels were significantly lower in Cftr((-/-)) GBEC compared with wild-type cells, whereas Muc2 mRNA levels ..
  67. ncbi Muc5b and Muc5ac are the major oligomeric mucins in equine airway mucus
    Karine Rousseau
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 292:L1396-404. 2007
    ..mass spectrometry of tryptic digests of the unfractionated mucin preparation showed that the oligomeric mucins Muc5b and Muc5ac were present...
  68. ncbi Upper airway mucus deposition in lung tissue of burn trauma victims
    Robert A Cox
    Shriners Hospital for Children and the University of Texas Medical Branch, Galveston, Texas 77550, USA
    Shock 29:356-61. 2008
    ..This study examines the localization of an upper airway gland specific mucus, mucin 5B (MUC5B) in lung autopsy tissues of burn-only injury and in victims of S + B injury...
  69. ncbi Salivary agglutinin/glycoprotein-340/DMBT1: a single molecule with variable composition and with different functions in infection, inflammation and cancer
    Antoon J M Ligtenberg
    Department of Oral Biochemistry, Academic Centre for Dentistry, Free University, Van de Boechorststraat 7, NL 1081 BT Amsterdam, The Netherlands
    Biol Chem 388:1275-89. 2007
    ..pylori, influenza viruses and HIV, but also with mucosal defence proteins, such as IgA, surfactant proteins and MUC5B. Stimulation of alveolar macrophage migration, suppression of neutrophil oxidative burst and activation of the ..
  70. doi Analyzing the functions of large glycoconjugates through the dissipative properties of their absorbed layers using the gel-forming mucin MUC5B as an example
    Mehmet Kesimer
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    Glycobiology 18:463-72. 2008
    ..and quartz crystal mass balance with dissipation methods (QCM-D) we have investigated the properties of the MUC5B mucin and its cognate fragments when bound to a hydrophobic surface...
  71. doi Four potential biomarkers as prognostic factors in stage III serous ovarian adenocarcinomas
    Karolina Partheen
    Department of Oncology, University of Gothenburg, Gothenburg, Sweden
    Int J Cancer 123:2130-7. 2008
    ..Genes selected from our previous microarray analysis (2006), CLU, ITGB3, TACC1, MUC5B, CAPG, PRAME and TROAP, were analyzed in 19 of the tumors with quantitative real-time polymerase chain reaction (..
  72. pmc Proteolytic degradation of human salivary MUC5B by dental biofilms
    Claes Wickström
    Department of Oral Biology, Faculty of Odontology, Malmo University, Malmo, Sweden
    Microbiology 155:2866-72. 2009
    ..The mucin MUC5B is a complex oligomeric glycoprotein, heterogeneous in molecular mass (14-40 x 10(6) Da), with a diverse ..
  73. pmc Mucin gene polymorphisms in otitis media patients
    Matthew L Ubell
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Laryngoscope 120:132-8. 2010
    Mucin genes MUC2, MUC5AC, and MUC5B have been identified as major gel-forming mucins in the middle ear (ME). This study compared polymorphisms in MUC2, MUC5AC, and MUC5B genes in otitis media (OM) patients and controls.
  74. doi Histatins enhance wound closure with oral and non-oral cells
    M J Oudhoff
    Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    J Dent Res 88:846-50. 2009
    ..saliva does not stimulate wound closure, most probably due to the presence of mucins, since the addition of MUC5B to parotid saliva abolished its effect...
  75. doi Equine bronchial epithelial cells differentiate into ciliated and mucus producing cells in vitro
    Ute E Schwab
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    In Vitro Cell Dev Biol Anim 46:102-6. 2010
    ..Furthermore, the demonstration of the two major gel-forming mucin species, Muc5ac and Muc5b, in our bronchial epithelial cell culture system validates this method for studies of respiratory tract disease of ..
  76. pmc Mucins in the pathogenesis of breast cancer: implications in diagnosis, prognosis and therapy
    Partha Mukhopadhyay
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Biochim Biophys Acta 1815:224-40. 2011
    ..a differential expression of both membrane bound (MUC1, MUC4 and MUC16) and secreted mucins (MUC2, MUC5AC, MUC5B and MUC6) in breast cancer tissues when compared with the non-neoplastic breast tissues...
  77. doi Expression of secreted mucins (MUC2, MUC5AC, MUC5B, and MUC6) and membrane-bound mucin (MUC4) in the lungs of pigs experimentally infected with Actinobacillus pleuropneumoniae
    Chung Hyun Kim
    Seoul National University, College of Veterinary Medicine, Department of Veterinary Pathology, 599 Gwanak Ro, Gwanak Gu, 151 742 Seoul, Republic of Korea
    Res Vet Sci 92:486-91. 2012
    The expression patterns of different secreted (MUC2, MUC5AC, MUC5B, and MUC6) and membrane-bound (MUC4) mucins were determined immunohistochemically in the lungs of pigs experimentally infected with Actinobacillus pleuropneumoniae...
  78. doi Polymorphisms in MUC1, MUC2, MUC5B and MUC6 genes are not associated with the risk of chronic atrophic gastritis
    Bernd Frank
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Eur J Cancer 48:114-20. 2012
    ..We genotyped MUC1 T31T, MUC2 L58P, MUC2 V116M, MUC5B E34G, MUC5B R51W, MUC5B rs2014486 (intronic) and MUC6 V619M for 533 serologically defined CAG cases and 1054 age- ..
  79. doi Recent advances in mucin immunohistochemistry in salivary gland tumors and head and neck squamous cell carcinoma
    Farzana Mahomed
    Division of Oral Pathology, Faculty of Health Sciences, University of the Witwatersrand, Private Bag 3, Wits 2050, South Africa
    Oral Oncol 47:797-803. 2011
    ..is available on changes in the expression levels and distribution profiles of MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6 and MUC7 in tumors of the salivary glands; and of MUC1, MUC2 and MUC4 in HNSCC...
  80. pmc Effects of ZnO nanoparticulate addition on the properties of PMNT ceramics
    Methee Promsawat
    Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
    Nanoscale Res Lett 7:65. 2012
    ..This research was conducted in order to study the effect of ZnO nanoparticulate addition on the properties of 0.9 Pb(Mg1/3Nb2/3)O3-0.1PbTiO3 [PMNT] ceramics. The PMNT ceramics were prepared by a solid-state reaction...
  81. pmc Coordinate regulation of the gel-forming mucin genes at chromosome 11p15.5
    Nehal Gosalia
    Human Molecular Genetics Program, Children s Memorial Research Center and Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
    J Biol Chem 288:6717-25. 2013
    ..LPS increased the expression of MUC2 and MUC5AC and reduced MUC5B. CTCF occupancy was concurrently depleted at specific binding sites close to these genes...
  82. doi Effect of thymic stromal lymphopoietin on MUC5B expression in human airway epithelial cells
    Chang Hoon Bae
    Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, Yeungnam University, Daegu, Republic of Korea
    Biochem Biophys Res Commun 448:231-5. 2014
    ..In human NCI-H292 airway epithelial cells, TSLP increased MUC5B expression. TSLP significantly activated phosphorylation of ERK1/2 and p38 mitogen-activated protein kinase (MAPK)...
  83. pmc Visfatin induces MUC8 and MUC5B expression via p38 MAPK/ROS/NF-κB in human airway epithelial cells
    Si Youn Song
    Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, Yeungnam University, Daegu, Republic of Korea
    J Biomed Sci 21:49. 2014
    ..Therefore, this study was conducted in order to investigate the effect and the brief signaling pathway of visfatin on MUC8 and MUC5B expression in human airway epithelial cells.
  84. doi MUC5B promoter polymorphisms and risk of coal workers' pneumoconiosis in a Chinese population
    Xiaoming Ji
    Department of Occupational Medicine and Environmental Health, School of Public Health, Nanjing Medical University, Nanjing, 210029, China
    Mol Biol Rep 41:4171-6. 2014
    ..Genetic variations have been recognized to be involved in the multi-factorial susceptibility to CWP, and MUC5B is a candidate lung fibrosis susceptibility gene...
  85. pmc Group I Paks as therapeutic targets in NF2-deficient meningioma
    Hoi Yee Chow
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Oncotarget 6:1981-94. 2015
    ..that these Pak inhibitors suppressed the proliferation and motility of both benign (Ben-Men1) and malignant (KT21-MG1) meningiomas cells...
  86. pmc Excess Secretion of Gel-Forming Mucins and Associated Innate Defense Proteins with Defective Mucin Un-Packaging Underpin Gallbladder Mucocele Formation in Dogs
    Mehmet Kesimer
    Department of Pathology and Laboratory Medicine and Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 10:e0138988. 2015
    ..The mucus is characterized by a disproportionally significant increase in Muc5ac relative to Muc5b, defective mucin un-packaging, and mucin-interacting innate defense proteins that are capable of dramatically ..
  87. doi On the Utility of Spinel Oxide Hosts for Magnesium-Ion Batteries
    James C Knight
    McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, United States
    ACS Appl Mater Interfaces 7:22953-61. 2015
    ..Samples with additional Mg(2+) ions in the octahedral sites (e.g., Mg1.1Mn1.9O4 and Mg1.5Mn1...
  88. doi Effect of Muc5b promoter polymorphism on disease predisposition and survival in idiopathic interstitial pneumonias
    Joanne J van der Vis
    St Antonius Interstitial Lung Disease Center, Department of Pulmonology, St Antonius Hospital, Nieuwegein, The Netherlands
    Respirology 21:712-7. 2016
    A common polymorphism in the MUC5B gene (rs35705950) is associated with susceptibility to idiopathic pulmonary fibrosis (IPF) and familial interstitial pneumonia (FIP)...
  89. pmc Control of lung defence by mucins and macrophages: ancient defence mechanisms with modern functions
    William J Janssen
    Dept of Medicine, National Jewish Health, Denver, CO, USA Dept of Medicine, University of Colorado School of Medicine, Aurora, CO, USA
    Eur Respir J 48:1201-1214. 2016
    ..data show that they are linked through their shared reliance on airway mucins, in particular the polymeric mucin MUC5B. This review highlights our understanding of novel mechanisms that link mucus and macrophage defences...
  90. pmc A mucin-like glycoprotein identified by MAG (mouse ascites Golgi) antibodies. Menstrual cycle-dependent localization in human endometrium
    H J Kliman
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023
    Am J Pathol 146:166-81. 1995
    ..Because the MAG epitope appears on the endometrial surface during the purported implantation window, we speculate that mucin-like epitopes could play a role in the earliest apposition phases of conceptus-endometrial interaction...
  91. pmc Expression and site-directed mutagenesis of mouse prostaglandin E2 receptor EP3 subtype in insect cells
    C Huang
    Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky, Lexington 40536, USA
    Biochem J 307:493-8. 1995
    ..The cloned cDNA was confirmed by sequencing and was expressed in Trichoplusia ni (MG1) insect cells using a baculovirus expression system...
  92. ncbi Interneurons of the ganglionic layer in the mormyrid electrosensory lateral line lobe: morphology, immunohistochemistry, and synaptology
    J Meek
    Department of Anatomy and Embryology, University of Nijmegen, The Netherlands
    J Comp Neurol 375:43-65. 1996
    ..layer, a single basal dendrite that gives rise to fine, beaded, axon-like branches in either the plexiform layer (MG1 subtype) or the deeper granular layer (MG2 subtype), and an axon that terminates in the plexiform layer...
  93. ncbi Mucin genes expressed by human female reproductive tract epithelia
    I K Gipson
    Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Reprod 56:999-1011. 1997
    ..The purpose of this study was to determine whether these cloned mucins, designated MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6, and MUC7, are expressed by epithelia of the female reproductive tract...
  94. ncbi Mucin gene expression in gallbladder epithelium with black pigment stone ascertained by in situ hybridization
    K T Lee
    Department of Surgery, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 17:517-23. 2001
    ..pigment stones (n = 10) and those without stones (n = 6) to identify the expression of MUC1, MUC2, MUC3, MUC4, MUC5B and MUC6 in gallbladder epithelium...
  95. ncbi Innate secretory immunity in response to laboratory stressors that evoke distinct patterns of cardiac autonomic activity
    Jos A Bosch
    Department of Dental Basic Sciences, Section Oral Biochemistry, Academic Centre for Dentistry Amsterdam, Amsterdam, The Netherlands
    Psychosom Med 65:245-58. 2003
    ..was empirically tested by measuring the salivary secretion of cystatin S, lactoferrin, alpha-amylase, the mucins MUC5B and MUC7, and total salivary protein in response to stressors known to evoke distinct patterns of cardiac ..
  96. ncbi The mormyromast region of the mormyrid electrosensory lobe. I. Responses to corollary discharge and electrosensory stimuli
    Claudia Mohr
    Neurological Sciences Institute, Oregon Health and Sciences University, Beaverton 97006, USA
    J Neurophysiol 90:1193-210. 2003
    ..been previously identified only morphologically, including: the two types of Purkinje-like medium ganglionic cells, MG1 and MG2; the thick smooth dendrite cells; and the medium fusiform cells...
  97. ncbi C-Mannosylation of MUC5AC and MUC5B Cys subdomains
    Juan Perez-Vilar
    Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Glycobiology 14:325-37. 2004
    ..The entire Cys1 and Cys5 and Cys1 and Cys3 subdomains in MUC5AC and MUC5B, respectively, each with six carboxyl terminal histidine residues, were pulse-labeled with [(35)S]cysteine/..
  98. ncbi Effect of MMP/ADAM inhibitors on goblet cell hyperplasia in cultured human bronchial epithelial cells
    Hajime Yoshisue
    Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co, Ltd, Sunto, Shizuoka 411 8731, Japan
    Biosci Biotechnol Biochem 68:2024-31. 2004
    ..The mucin genes MUC5AC, MUC5B, and MUC2 were upregulated whereas the expression of ciliated cell markers was greatly repressed...
  99. ncbi Human carcinoma-associated and salivary mucins detected by anti-bovine submaxillary mucin antibodies
    S J Golubović
    Institute for the Application of Nuclear Energy INEP, Zemun Belgrade, Serbia and Montenegro
    Biochemistry (Mosc) 71:S9-17. 2006
    ..detected by autoradiography, as bands of 85 and 115 kD, and densitogram analysis also demonstrated reaction with MUC5B. Chemical modifications performed as periodate oxidation and desialylation of the BSM demonstrated carbohydrate (i...
  100. pmc Alterations in the composition of the supramucosal defense barrier in relation to disease severity of ulcerative colitis
    Rob J Longman
    University Department of Surgery, Bristol Royal Infirmary, Bristol, United Kingdom
    J Histochem Cytochem 54:1335-48. 2006
    ..No ectopic expression of MUC5AC, MUC5B, or MUC6 was identified in UC...

Research Grants38

  1. Diego Preciado; Fiscal Year: 2015
    ..We have recently shown that the hyperviscous mucus in COM is characterized by an overabundance of MUC5B mucin, a major airway secreted mucin...
  2. Regulation of MUC19 by Th2 cytokine in airway epithelium
    Yin Chen; Fiscal Year: 2011
    ..of the "surface" type of gel-forming mucin -MUC5AC to the co-expression with the submucosal gland-specific MUC5B and MUC19, a novel gel-forming we newly discovered, in airway diseases...
  3. Christopher M Evans; Fiscal Year: 2016
    ..MUC5AC and MUC5B are the major secreted airway mucins...
  4. Mehmet Kesimer; Fiscal Year: 2014
    ..Airway mucins, particularly MUC5AC and MUC5B, are the major constituent of the mucus gel and play an important role in the mucociliary clearance...
  5. Mehmet Kesimer; Fiscal Year: 2014
    ..to elucidate the organization of the airway gel layer, which is formed by very large glycoproteins termed mucins (MUC5B and MUC5AC) coupled with other protective biomolecules through labile interactions, and assess the role of these ..
  6. Prenatal Bisphenol A and Lung Maturation
    Laura S Van Winkle; Fiscal Year: 2013
    ..shows more abundant airway epithelial mucosubstances in the conducting airways and increases in gene expression of MUC5B and CCSP in the fetal rhesus monkey lung exposed to BPA...
  7. IMMUNOCHEMISTRY OF SALIVARY MUCINS IN DENTAL DISEASE
    Robert Cohen; Fiscal Year: 1992
    ..in human saliva: The lower molecular weight species MG2, and the high molecular weight, multi-subunit component MG1. Both mucins are composed of several structural domains, each of which may be responsible for discrete biological ..
  8. MUCIN AND NON-MUCIN PROTEINS IN GALLSTONE PATHOGENESIS
    Gwynneth Offner; Fiscal Year: 2000
    ..Human gallbladder expresses genes for five different mucins and two of these, MUC5B and MUC3 have been identified as the major human gallbladder mucins...
  9. MUC19, a novel gel-forming mucin in salivary glands
    Yin Chen; Fiscal Year: 2005
    ..Comparing with the known major salivary gland gel-forming mucin-MUC5B, MUC19 appears to be much larger and more abundantly expressed in salivary glands...
  10. COLON CELL DIFFERENTIATION--DCC ROLE IN MUC2 EXPRESSION
    Leonard Augenlicht; Fiscal Year: 2000
    ..MUC2 gene and its promotor and enhancer, and have found this contig contains another mucin backbone gene, probably MUC5b, which is also expressed in colonic cells both in vivo and in vitro, that could be coordinately regulated with ..
  11. SALIVARY MUCIN, SYNTHESIS, PROCESSING AND SECRETION
    Paul Denny; Fiscal Year: 2000
    ..These mucins appear to be analogous to the human salivary mucins, MG1 and MG2...
  12. DAVID ALBERT SCHWARTZ; Fiscal Year: 2016
    ..The proposed research builds on our recent observations that a common polymorphism in the promoter of MUC5B and cigarette smoke are strongly associated with the development of both familial interstitial pneumonia (FIP) and ..
  13. HOST DEFENSE FACTORS IN ORAL ECOLOGY
    JOEL RUDNEY; Fiscal Year: 1991
    ..Lz), lactoferrin (Lf), salivary peroxidase (Spx), secretory immunoglobulin A (sIgA), the mucin glycoproteins (MG1 and MG2), and others less well known...
  14. SALIVARY AND TRACHEOBRONCHIAL MUCINS IN DISEASE
    MOLAKALA REDDY; Fiscal Year: 1991
    ..pneumoniae and Enterobacter species. These organisms colonize the oropharynx prior to initiation of infection. MG1 (mucin derived from submandibular-sublingual saliva) which has the potential to selectively interact with a variety ..
  15. Attenuation of mucous cell metaplasia by Rad
    Mary Chang; Fiscal Year: 2006
    ..Both Northern blot and RealTime RT-PCR analysis demonstrated that the steady state level of MUC5B/MUC5AC mRNA were drastically inhibited by Rad...
  16. THE WHOLE GENOME SEQUENCE OF ACTINOMYCES NAESLUNDI
    Timothy Read; Fiscal Year: 2001
    ..The A. naeslundii strain to be sequenced is an isolate called MG1, which is the prominent A...
  17. Membrane Bound Mucins in Salivary Glands and Saliva
    Gwynneth D Offner; Fiscal Year: 2010
    ..These interactions may represent new therapeutic targets to treat or prevent oral infections and periodontal disease. ..
  18. CHOLESTEROL TRANSPORT IN GALLBLADDER EPITHELIAL CELLS
    Rahul Kuver; Fiscal Year: 2003
    ..3. Compare and contrast the mechanisms of activation of ABCA1 via the cAMP responsive and the LXRalpha/RXR- responsive pathways. ..
  19. MUCIN SECRETION IN COLUMNAR EPITHELIAL CELLS
    Rahul Kuver; Fiscal Year: 2003
    ..The sponsor's group's expertise in biliary cell biology will ensure a supportive and stimulating environment for the candidate. ..
  20. NEGATIVE REGULATORY ELEMENT OF HAMSTER MUC 1 PROMOTER
    Kwang Kim; Fiscal Year: 2003
    ....
  21. Colon Cell Differentiation: NAB and MUC2 Gene Expression
    Anna Velcich; Fiscal Year: 2009
    ..5. Finally, we will extend our use of microarray technology to determine how NaB perturbs profiles of gene expression that define lineage specific differentiation (Velcich et al., submitted). ..
  22. Biliary oxysterols and cholangiocarcinoma
    RAHUL P KUVER; Fiscal Year: 2010
    ..abstract_text> ..
  23. A Sequencing Microarray for Mitochondrial Mutations
    Anirban Maitra; Fiscal Year: 2004
    ..This study will serve as a model for array-based diagnosis of cancer in clinical samples. ..
  24. Anti-inflammatory role of MUC1 mucin
    Kwang Chul Kim; Fiscal Year: 2010
    ..R5 signal transduction. Successful completion of this project will provide important insights for the role of MIJC1 in inflammation, innate immunity, and the early stages of PA infection in CF. ..
  25. STRUCTURE AND FUNCTION OF HUMAN SALIVARY MUCINS
    Gwynneth Offner; Fiscal Year: 2009
    ..MG1 appears to be a mixture of two mucin gene products, MUC5B and a newly identified mucin, MUC19. MG2 appears to contain a single mucin gene product, MUC7...
  26. IL13-responsive genes in goblet cell metaplasia in asthma
    Mary Rose; Fiscal Year: 2007
    ..This will contribute to the development of pharmacological agents to control GCH and mucus overproduction in patients with asthma and possibly other chronic airway diseases [unreadable] [unreadable] [unreadable]..
  27. Hedgehog signaling in pancreatic neoplasia
    Anirban Maitra; Fiscal Year: 2006
    ..Specifically, it will be determined whether Hh misexpression can generate a phenotype of multistep progression of pancreatic cancer that resembles the cognate human condition. [unreadable] [unreadable]..
  28. Immunomodulatory Mechanisms of Sublingual Immunotherapy
    Louis Rosenthal; Fiscal Year: 2006
    ..To investigate this controversial therapy, these studies will use a novel rat model to compare the efficacy of high vs. low doses of allergen drops and to elucidate mechanisms of sublingual immunotherapy. ..
  29. Detection and Role of C-Mannosylation in Mucins
    JUAN PEREZ VILAR; Fiscal Year: 2006
    ..Our preliminary data suggest the Cys subdomains in MUC5AC and MUC5B are C-mannosylated when expressed in cultured animal cells...
  30. Murine Cytomegalovirus Modulates Allergic Airway Disease
    Carol Wu; Fiscal Year: 2005
    ..Furthermore, we hypothesize that enhanced mucus production is the result of the recruitment/proliferation of TCRgd cells, in response to MCMV infected respiratory epithelium, with the subsequent release of IL-l0. ..
  31. Middle Ear Epithelial Response to Cytokine Stimulation
    Joseph Kerschner; Fiscal Year: 2005
    ....
  32. Inactivation of the Muc2 gene and colorectal cancer
    Anna Velcich; Fiscal Year: 2005
    ....
  33. Quantitative Array Piezoelectric Microcantilever Sensors
    WAN SHIH; Fiscal Year: 2004
    ..abstract_text> ..