MUC5AC

Summary

Gene Symbol: MUC5AC
Description: mucin 5AC, oligomeric mucus/gel-forming
Alias: MUC5, TBM, leB, mucin, mucin-5AC, gastric mucin, lewis B blood group antigen, major airway glycoprotein, mucin 5, subtypes A and C, tracheobronchial/gastric, mucin 5AC, oligomeric mucus/gel-forming pseudogene, mucin-5 subtype AC, tracheobronchial, tracheobronchial mucin
Species: human

Top Publications

  1. pmc Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?
    V Guyonnet Duperat
    Unité INSERM N 377, Lille, France
    Biochem J 305:211-9. 1995
  2. ncbi Impact of ethanol on innate protection of gastric mucosal epithelial surfaces and the risk of injury
    A Slomiany
    Research Center, University of Medicine and Dentistry of New Jersey, Newark, 07103 2400, USA
    J Physiol Pharmacol 51:433-47. 2000
  3. pmc Purification and characterization of a surface protein from Lactobacillus fermentum 104R that binds to porcine small intestinal mucus and gastric mucin
    Maurilia Rojas
    Universidad Autonoma de Baja California Sur, 23000 La Paz, Baja California Sur, Mexico
    Appl Environ Microbiol 68:2330-6. 2002
  4. ncbi Mapping of two new epitopes on the apomucin encoded by MUC5AC gene: expression in normal GI tract and colon tumors
    Séverine Nollet
    INSERM U 482, Hopital Saint Antoine, Paris, France
    Int J Cancer 99:336-43. 2002
  5. pmc The characterisation of mucin in a mature ovarian teratoma occurring in an eight year old patient
    Anwar Suleman Mall
    Departments of Surgery, Groote Schuur and Red Cross Hospitals, University of Cape Town, Cape Town, South Africa
    Int J Med Sci 4:115-23. 2007
  6. ncbi Characterization of a mucin cDNA clone isolated from HT-29 mucus-secreting cells. The 3' end of MUC5AC?
    T Lesuffleur
    INSERM U178, Batiment INSERM, Villejuif, France
    J Biol Chem 270:13665-73. 1995
  7. ncbi Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts
    D Li
    Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 273:6812-20. 1998
  8. ncbi Polymorphism of human mucin genes in chest disease: possible significance of MUC2
    L E Vinall
    MRC Human Biochemical Genetics Unit, The Galton Laboratory, University College London, London, United Kingdom
    Am J Respir Cell Mol Biol 23:678-86. 2000
  9. pmc Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region
    F Escande
    INSERM Unité 377, Place de Verdun, 59045 Lille Cedex, France
    Biochem J 358:763-72. 2001
  10. pmc Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution
    Henrik Nordman
    Mucosal Biology Group, Department of Cell and Molecular Biology, Level C13, BMC Lund University, S 221 84, Lund, Sweden
    Biochem J 364:191-200. 2002

Research Grants

  1. LAURA ELIZABETH MARTINEZ; Fiscal Year: 2015
  2. IL8-induced Post-transcriptional Regulation of the MUC5AC mucin gene
    Mary C Rose; Fiscal Year: 2010
  3. Stephen C Pflugfelder; Fiscal Year: 2016
  4. REGULATION OF GASTRIC MUCIN SYNTHESIS
    CLEMENT BOLAND; Fiscal Year: 1990
  5. Regulation of MUC19 by Th2 cytokine in airway epithelium
    Yin Chen; Fiscal Year: 2011
  6. Modulation of conjunctival goblet cell differentiation by immunoregulatory cells
    Cintia Sade de Paiva; Fiscal Year: 2010
  7. Pi Wan Cheng; Fiscal Year: 2015
  8. Specialized molecules with essential roles in mucus production
    David J Erle; Fiscal Year: 2013
  9. Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
    Reen Wu; Fiscal Year: 2013
  10. Darlene A Dartt; Fiscal Year: 2015

Detail Information

Publications257 found, 100 shown here

  1. pmc Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?
    V Guyonnet Duperat
    Unité INSERM N 377, Lille, France
    Biochem J 305:211-9. 1995
    ..The data suggest that MUC5A and MUC5C are part of the same gene (called MUC5AC) which is distinct from MUC5B...
  2. ncbi Impact of ethanol on innate protection of gastric mucosal epithelial surfaces and the risk of injury
    A Slomiany
    Research Center, University of Medicine and Dentistry of New Jersey, Newark, 07103 2400, USA
    J Physiol Pharmacol 51:433-47. 2000
    ..The retention of mucin on the surface of gastric mucosa was quantitated by measuring the binding of gastric mucin to Mucin Binding Protein (MBP) of gastric mucosa...
  3. pmc Purification and characterization of a surface protein from Lactobacillus fermentum 104R that binds to porcine small intestinal mucus and gastric mucin
    Maurilia Rojas
    Universidad Autonoma de Baja California Sur, 23000 La Paz, Baja California Sur, Mexico
    Appl Environ Microbiol 68:2330-6. 2002
    ..of Lactobacillus fermentum strain 104R to small intestinal mucus from piglets and to partially purified gastric mucin was isolated and characterized...
  4. ncbi Mapping of two new epitopes on the apomucin encoded by MUC5AC gene: expression in normal GI tract and colon tumors
    Séverine Nollet
    INSERM U 482, Hopital Saint Antoine, Paris, France
    Int J Cancer 99:336-43. 2002
    ..We have mapped 2 new gastric mucin epitopes and the M1-f epitope previously characterized by the 19/21M1 MAbs on MUC5AC-encoded apomucin...
  5. pmc The characterisation of mucin in a mature ovarian teratoma occurring in an eight year old patient
    Anwar Suleman Mall
    Departments of Surgery, Groote Schuur and Red Cross Hospitals, University of Cape Town, Cape Town, South Africa
    Int J Med Sci 4:115-23. 2007
    The presence of MUC5AC (M1 antigen) and MUC6 have previously been found in ovarian mucinous cyst. We characterized the mucins in the crude mucus and tissue of a mature ovarian teratoma in an 8 year old girl.
  6. ncbi Characterization of a mucin cDNA clone isolated from HT-29 mucus-secreting cells. The 3' end of MUC5AC?
    T Lesuffleur
    INSERM U178, Batiment INSERM, Villejuif, France
    J Biol Chem 270:13665-73. 1995
    ..5. The patterns of mRNA expression were indistinguishable from those revealed with the JER58 probe (MUC5AC). Southern blot analysis indicates that the L31 and JER 58 sequences are within 20 kilobase pairs of each other...
  7. ncbi Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts
    D Li
    Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 273:6812-20. 1998
    ..of rapid amplification of cDNA ends-polymerase chain reaction (RACE-PCR) in which the 5' sequence of the human gastric mucin cDNA HGM-1 (1) was used to design the first MUC5AC-specific primer...
  8. ncbi Polymorphism of human mucin genes in chest disease: possible significance of MUC2
    L E Vinall
    MRC Human Biochemical Genetics Unit, The Galton Laboratory, University College London, London, United Kingdom
    Am J Respir Cell Mol Biol 23:678-86. 2000
    ..There was no significant difference in the distribution of alleles of MUC1, MUC4, MUC5AC, and MUC5B. MUC2, however, showed a highly significant difference in distribution...
  9. pmc Human mucin gene MUC5AC: organization of its 5'-region and central repetitive region
    F Escande
    INSERM Unité 377, Place de Verdun, 59045 Lille Cedex, France
    Biochem J 358:763-72. 2001
    Human mucin gene MUC5AC is clustered with MUC2, MUC5B and MUC6 on chromosome 11p15.5. We report here the full length cDNA sequence upstream of the repetitive region of human MUC5AC...
  10. pmc Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution
    Henrik Nordman
    Mucosal Biology Group, Department of Cell and Molecular Biology, Level C13, BMC Lund University, S 221 84, Lund, Sweden
    Biochem J 364:191-200. 2002
    Gastric MUC5AC and MUC6 mucins were studied using polyclonal antibodies. Immunohistochemistry showed MUC5AC to originate from the surface epithelium, whereas MUC6 was produced by the glands...
  11. ncbi Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist
    Ja Seok Koo
    Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Exp Lung Res 28:315-32. 2002
    ..In this study, we demonstrated that interleukin-1beta (IL-1beta) increased MUC2 and MUC5AC mRNA levels 2- to 3-fold in a time- and dose-dependent manner in NCI-H292 cells...
  12. ncbi Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas
    Grace E Kim
    Gastrointestinal Research Laboratory, Department of Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Gastroenterology 123:1052-60. 2002
    ..This study examined alterations in the pattern and the level of expression of several mucin genes (MUC1, MUC2, MUC5AC, and MUC6) and mucin-associated tumor antigens (Nd2 and sialyl Tn) in these precursor lesions.
  13. ncbi Correlation of MUC5AC immunoreactivity with histopathological subtypes and prognosis of gastric carcinoma
    Stephan E Baldus
    Institute of Pathology and Center of Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
    Ann Surg Oncol 9:887-93. 2002
    b>MUC5AC represents a mucin peptide core expressed in normal gastric epithelia. Its presence in gastric carcinomas was previously described as a characteristic of gastric differentiation.
  14. ncbi Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells
    Kyoung Seob Song
    Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul 120 752, Korea
    J Biol Chem 278:23243-50. 2003
    Mucin hypersecretion is commonly observed in many inflammatory diseases of the respiratory tract. MUC5AC is generally recognized to be a major airway mucin because MUC5AC is highly expressed in the goblet cells of human airway epithelium...
  15. ncbi Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1beta in human bronchial epithelia
    Thomas Gray
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Physiol Lung Cell Mol Physiol 286:L320-30. 2004
    ..Fully differentiated NHTBE cultures secreted two major airway mucins, MUC5AC and MUC5B. IL-1beta, in a dose- and time-dependent manner, increased the secretion of MUC5AC, but not MUC5B...
  16. ncbi The MUC5AC glycoprotein is the primary receptor for Helicobacter pylori in the human stomach
    Jeroen H B Van De Bovenkamp
    Laboratory of Pediatrics, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Helicobacter 8:521-32. 2003
    ..In infected patients, H. pylori colocalizes in situ with the gastric secretory mucin MUC5AC. The carbohydrate blood-group antigen Lewis B (LeB) was deemed responsible for the adherence of H...
  17. ncbi MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions
    Markus O Henke
    Department of Pulmonary Medicine, Philipps University Marburg, Germany
    Am J Respir Cell Mol Biol 31:86-91. 2004
    ..is due in part to mucus hypersecretion, there are no published data showing an increase in the gel-forming mucins MUC5AC or MUC5B in CF secretions...
  18. ncbi Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme
    Matt X G Shao
    Cardiovascular Research Institute and Departments of Medicine and Physiology, University of California San Francisco, San Francisco, California 94143, USA
    J Immunol 175:4009-16. 2005
    ..exists in high concentrations (1-20 microM) in airway secretions of these patients and induces overproduction of MUC5AC mucin, a major component of airway mucus...
  19. ncbi Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric otitis media with effusion
    Mohamed Nasser Elsheikh
    Department of Otolaryngology, Tanta University, Egypt
    Laryngoscope 116:365-9. 2006
    ..We investigated the expression of MUC5AC and MUC5B mucin gene messenger (m)RNAs in middle ear effusions as well as in tissue biopsies of the respiratory ..
  20. pmc MUC5AC, a gel-forming mucin accumulating in gallstone disease, is overproduced via an epidermal growth factor receptor pathway in the human gallbladder
    Laetitia Finzi
    INSERM U680, Faculté de Médecine Pierre et Marie Curie Université Pierre et Marie Curie Paris 6, site Saint Antoine, 27 rue Chaligny, 75571 Paris Cedex 12, France
    Am J Pathol 169:2031-41. 2006
    ..of TNF-alpha, EGF-R ligands (either EGF or transforming growth factor-alpha) caused significant increases in MUC5AC mRNA and protein production, whereas expression of the other gallbladder mucins MUC1, MUC3, and MUC5B was ..
  21. ncbi A novel role for IkappaB kinase (IKK) alpha and IKKbeta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae
    Unhwan Ha
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Immunol 178:1736-47. 2007
    ..In this study, we show that pneumolysin is required for up-regulation of MUC5AC mucin via TLR4-dependent activation of ERK in human epithelial cells in vitro and in mice in vivo...
  22. pmc Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF
    Yuxian Huang
    Department of Microbiology and Immunology, Box 672, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 359:691-6. 2007
    ..Despite extensive studies that focus on investigating how MUC5AC mucin is regulated by one inducer at a time, how MUC5AC is synergistically regulated by multiple factors remains ..
  23. ncbi The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic rhinosinusitis and nasal polyposis
    Guo Qiang Ding
    Department of Otorhinolaryngology Head and Neck Surgery, Eye and ENT Hospital of Fudan University, Shanghai, China
    Am J Rhinol 21:359-66. 2007
    The aim of this study was to investigate the expression of MUC5AC and MUC5B messenger RNAs (mRNAs) and localization of these proteins in human sinus mucosa of chronic rhinosinusitis (CRS) and CRS with nasal polyposis (CRS/NP).
  24. pmc Regulation of mucin gene expression by CREB via a nonclassical retinoic acid signaling pathway
    Seung Wook Kim
    Department of Thoracic Head and Neck Medical Oncology, Unit 432, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cell Biol 27:6933-47. 2007
    ..plays a critical role in regulating the expression of airway epithelial cell differentiation markers, the MUC2, MUC5AC, and MUC5B genes...
  25. ncbi Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease
    Isao Nakao
    Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
    J Immunol 180:6262-9. 2008
    ..Pendrin induced expression of MUC5AC, a major product of mucus in asthma and COPD, in airway epithelial cells...
  26. pmc MKP1 regulates the induction of MUC5AC mucin by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway
    Un Hwan Ha
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 283:30624-31. 2008
    ..that the PAK4-JNK signaling pathway acted as a negative regulator for Streptococcus pneumoniae pneumolysin-induced MUC5AC mucin transcription...
  27. doi LPS-stimulated MUC5AC production involves Rac1-dependent MMP-9 secretion and activation in NCI-H292 cells
    Marcelo G Binker
    CBRHC Research Center, Buenos Aires, Argentina
    Biochem Biophys Res Commun 386:124-9. 2009
    ..Previous studies have reported that lipopolysaccharides (LPS) stimulate mucin 5AC (MUC5AC) production via epidermal growth factor receptor (EGFR) in human airway cells...
  28. doi Regulation of neuregulin 1beta1-induced MUC5AC and MUC5B expression in human airway epithelium
    Rachel Kettle
    Novartis Institutes for BioMedical Research, Respiratory Disease Area, Wimblehurst Road, Horsham, West Sussex RH125AB, UK
    Am J Respir Cell Mol Biol 42:472-81. 2010
    ..The mucins, MUC5AC and MUC5B, contribute to the viscoelastic properties of mucus, and are found at elevated levels in the airways of ..
  29. doi [6]-Gingerol suppresses interleukin-1 beta-induced MUC5AC gene expression in human airway epithelial cells
    Jeong Hong Kim
    Department of Otorhinolaryngology, Cheju National University College of Medicine, Jeju, South Korea
    Am J Rhinol Allergy 23:385-91. 2009
    ..The present study investigated whether [6]-gingerol suppresses interleukin (IL)-1 beta-induced MUC5AC gene expression in human airway epithelial cells and, if so, examined whether the suppression of MUC5AC gene ..
  30. doi MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients
    Gaetano Caramori
    Centro di Ricerca su Asma e BPCO, University of Ferrara, Via Savonarola 9, Ferrara 44121, Italy
    Histopathology 55:321-31. 2009
    Mucus expectoration is a common feature of chronic obstructive pulmonary disease (COPD). MUC5AC and MUC5B, the major mucins, are released predominantly from submucosal glands in the central airways...
  31. doi Combination of MUC5ac and WT-1 immunohistochemistry is useful in distinguishing pancreatic ductal carcinoma from ovarian serous carcinoma in effusion cytology
    Liying Han
    Department of Pathology, Wayne State University and Karmanos Cancer Institute, Detroit, Michigan, USA
    Diagn Cytopathol 38:333-6. 2010
    ..We evaluated the immunohistochemical staining of eight commercially available antibodies MUC1, MUC2, MUC5ac, Wilm's tumor susceptibility gene 1 (WT1), cytokeratin 7 (CK7), CK20, CA125, and CA19...
  32. doi Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-κB and EGFR pathways
    C A Hewson
    Dept of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London, W2 1PG, UK
    Eur Respir J 36:1425-35. 2010
    ..b>MUC5AC is the major mucin produced by bronchial epithelial cells...
  33. doi Expression of MUC5AC, an early marker of pancreatobiliary cancer, is regulated by DNA methylation in the distal promoter region in cancer cells
    Norishige Yamada
    Department of Human Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, 890 8544, Japan
    J Hepatobiliary Pancreat Sci 17:844-54. 2010
    High de novo expression of MUC5AC (a gastric-type secreted mucin) is observed in many types of pancreatobiliary neoplasms, including precursor lesions...
  34. doi GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin
    S Inaguma
    Department of Pathology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan
    Oncogene 30:714-23. 2011
    ..Increased expression of a gel-forming mucin, MUC5AC, was previously revealed as a major biomarker for the poor prognosis of PDA patients, but the molecular mechanisms ..
  35. doi Tumor-associated MUC5AC stimulates in vivo tumorigenicity of human pancreatic cancer
    Hirotaka Hoshi
    Biomedical Research Laboratories, Kureha Corporation, Hyakunin cho, Tokyo, Japan
    Int J Oncol 38:619-27. 2011
    b>MUC5AC, a high molecular weight glycoprotein, is overexpressed in the ductal region of human pancreatic cancer but is not detectable in the normal pancreas, suggesting its association with disease development...
  36. pmc Muc5ac: a critical component mediating the rejection of enteric nematodes
    Sumaira Z Hasnain
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, England, UK
    J Exp Med 208:893-900. 2011
    De novo expression of Muc5ac, a mucin not normally expressed in the intestinal tract, is induced in the cecum of mice resistant to Trichuris muris infection...
  37. doi MUC5AC expression through bidirectional communication of Notch and epidermal growth factor receptor pathways
    Jin Hyun Kang
    Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Gyeonggi do 426 791, South Korea
    J Immunol 187:222-9. 2011
    ..We investigated the involvement of Notch signaling in MUC5AC expression in NCI-H292 cells, a human lung carcinoma cell line...
  38. pmc Mucin variable number tandem repeat polymorphisms and severity of cystic fibrosis lung disease: significant association with MUC5AC
    Xueliang Guo
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 6:e25452. 2011
    ..by Southern blot or PCR to define variable number tandem repeat (VNTR) length polymorphisms for MUC1, MUC2, MUC5AC, and MUC7...
  39. pmc Cigarette smoke induces MUC5AC protein expression through the activation of Sp1
    Y Peter Di
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Biol Chem 287:27948-58. 2012
    ..b>MUC5AC is the major inducible mucus gene in the airway...
  40. doi MUC5AC protects pancreatic cancer cells from TRAIL-induced death pathways
    Hirotaka Hoshi
    Biomedical Research Laboratories, Kureha Corporation, Shinjuku ku, Tokyo 169 8503, Japan
    Int J Oncol 42:887-93. 2013
    We have previously reported that a specific siRNA transfected MUC5AC could knockdown MUC5AC expression and suppress in vivo tumor growth and metastasis, although it had no effects on in vitro cell growth, cell survival, proliferation and ..
  41. pmc Rhythmic pressure waves induce mucin5AC expression via an EGFR-mediated signaling pathway in human airway epithelial cells
    Chunyi Liu
    Division of Respiratory Medicine, Second Affiliated Hospital, Chongqing Medical University, Yuzhong District, Chongqing, China
    DNA Cell Biol 32:423-9. 2013
    ..As a major component of ASL, we speculated that the mucin5AC (MUC5AC) expression must also be regulated by RPW. However, fewer researches have focused on this question...
  42. doi Decreased Muc5AC expression is associated with poor prognosis in gastric cancer
    Sung Mi Kim
    Department of Pathology, Pusan National University Hospital and Pusan National University School of Medicine, and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea
    Int J Cancer 134:114-24. 2014
    ..We investigated the effect of Muc5AC, a secreted mucin, on the invasiveness/migratory capability of gastric cancer cells and the prognostic ..
  43. pmc Genomic organization of the 3'-region of the human MUC5AC mucin gene: additional evidence for a common ancestral gene for the 11p15.5 mucin gene family
    M P Buisine
    INSERM Unité 377, Place de Verdun, 59045 Lille Cedex, France
    Biochem J 332:729-38. 1998
    The human mucin gene MUC5AC is mapped clustered with MUC2, MUC5B and MUC6 on chromosome 11p15.5...
  44. ncbi Abnormal expression of M1/MUC5AC mucin in distal colon of patients with diverticulitis, ulcerative colitis and cancer
    Marie Elisabeth Forgue-Lafitte
    INSERM U673, 184 rue du Faubourg Saint Antoine, F 75012 Paris, France
    Int J Cancer 121:1543-9. 2007
    The abnormal expression of gastric M1/MUC5AC mucin in precancerous lesions and colon cancer evidenced by immunohistochemistry led us to check for its presence in the mucus obtained directly from patients undergoing surgery for cancerous (..
  45. pmc Roles for transforming growth factor-alpha in gastric physiology and pathophysiology
    R J Coffey
    Department of Medicine and Cell Biology, Vanderbilt University, Nashville, Tennessee 37232
    Yale J Biol Med 65:693-704; discussion 621-3. 1992
    ..This last effect is associated with a time- and dose-dependent increase in levels of insoluble gastric mucin. Based on these known biological actions of TGF alpha, we have examined TGF alpha production in Méné..
  46. ncbi Structure, function and gene expression of epithelial mucins
    E Seregni
    Nuclear Medicine Department, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan
    Tumori 83:625-32. 1997
    ..and biochemical studies, it is now possible to identify eight apomucin genes, namely MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC6 and MUC7...
  47. ncbi [Effects of phosphodiesterase-4 inhibitor on the mucin secretion in airway stimulated with acrolein: experiment with rats]
    Xun Wang
    Division of Pulmonary Diseases, National Key Laboratory of Biotherapy of Human Diseases, Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
    Zhonghua Yi Xue Za Zhi 88:2988-93. 2008
    To examine the effects of YM976, a phosphodiesterase (PDE)4 inhibitor, on mucin hypersecretion of airway stimulated with acrolein.
  48. doi An immunohistochemical profile of the so-called bile duct adenoma: clues to pathogenesis
    Norman R Hughes
    Department of Medicine, Melbourne University Medical School Building, Western Hospital, Footscray, Victoria, Australia
    Am J Surg Pathol 34:1312-8. 2010
    ..Five foregut antigens (D10, 1F6, MUC6, MUC5AC, and TFF2) and secretion of acid mucin were of use in distinguishing bile duct adenoma from other hepatic lesions...
  49. ncbi Mucin granule intraluminal organization in living mucous/goblet cells. Roles of protein post-translational modifications and secretion
    Juan Perez-Vilar
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina, Chapel Hill, North Carolina 27599 7248, USA
    J Biol Chem 281:4844-55. 2006
    ..Using a green fluorescent protein-mucin fusion protein (SHGFP-MUC5AC/CK) as a FRAP (fluorescence recovery after photobleaching) probe, we have assessed in living mucous cells the ..
  50. ncbi Colonic expression of MUC2, MUC5AC, and TFF1 in inflammatory bowel disease in children
    Ron Shaoul
    Department of Pediatrics, Bnai Zion Medical Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Pediatr Gastroenterol Nutr 38:488-93. 2004
    ..mucins, and used specific antibodies to the mature goblet cell mucin MUC2, MUC2 core antigen, foveolar cell mucin MUC5AC, and gastric trefoil factor (TFF1), to characterize their presence and distribution in colonic tissue sections ..
  51. ncbi Co-expression of gastric and biliary phenotype in pyloric-gland type adenoma of the gallbladder: immunohistochemical analysis of mucin profile and CD10
    Shigenori Nagata
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Oncol Rep 17:721-9. 2007
    ..Immunostainings were performed for mucin markers such as MUC5AC, human gastric mucin (HGM) for gastric foveolar type epithelium, MUC6, M-GGMC-1 for pyloric-gland type and MUC2 for intestinal ..
  52. pmc A morphometric study of mucins and small airway plugging in cystic fibrosis
    Pierre Regis Burgel
    Service de Pneumologie, Hopital Cochin, Universite Rene Descartes, 27 rue du Faubourg St Jacques, 75 679 Paris Cedex 14, France
    Thorax 62:153-61. 2007
    ..Little knowledge exists on structural changes and plugging in small airways in cystic fibrosis...
  53. ncbi Up-regulation of mucin secretion in HT29-MTX cells by the pro-inflammatory cytokines tumor necrosis factor-alpha and interleukin-6
    M G Smirnova
    Department of Physiological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Eur Cytokine Netw 12:119-25. 2001
    ..The MUC5AC and MUC5B mucin gene products have been identified as components of these effusions...
  54. ncbi Normal respiratory mucosa, precursor lesions and lung carcinomas: differential expression of human mucin genes
    M C Copin
    Laboratoire de Biochimie et Biologie Moleculaire, Hopital C Huriez CHRU Lille, France, Faculte de Medecine, Universite de Lille II, Lille, France
    Front Biosci 6:D1264-75. 2001
    ..Eight human mucin genes have been well characterized: MUC2, MUC5AC, MUC5B, MUC6 map to 11p15...
  55. pmc Glycoside hydrolase family 89 alpha-N-acetylglucosaminidase from Clostridium perfringens specifically acts on GlcNAc alpha1,4Gal beta1R at the non-reducing terminus of O-glycans in gastric mucin
    Masaya Fujita
    Noguchi Institute, 1 8 1 Kaga, Itabashi, Tokyo 173 0003, Japan
    J Biol Chem 286:6479-89. 2011
    ..AgnC also released GlcNAc from porcine gastric mucin and cell surface mucin...
  56. ncbi Differential expression of mucin genes in mammary and extramammary Paget's disease
    S F Kuan
    Department of Pathology, University of Chicago Hospital, Chicago, Illinois 60637, USA
    Am J Surg Pathol 25:1469-77. 2001
    ..We studied the immunohistochemical expression of apomucin MUC1, MUC2, MUC5AC in MPD, and EMPD. MUC1 is commonly expressed in most cases of PD...
  57. ncbi Model systems for investigating mucin gene expression in airway diseases
    M C Rose
    Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    J Aerosol Med 13:245-61. 2000
    ..Several inflammatory mediators have now been shown to regulate expression of MUC2, MUC5AC, and MUC5B genes...
  58. ncbi MUC2 is a molecular marker for pseudomyxoma peritonei
    Jerome T O'Connell
    Department of Pathology, UCLA School of Medicine, Los Angeles, California 90024, USA
    Mod Pathol 15:958-72. 2002
    ..Our study specifically investigated MUC2 and MUC5AC because these two mucins possessed the physicochemical property of being gel-forming, a property exhibited by ..
  59. ncbi Expression of membrane-bound mucins (MUC1 and MUC4) and secreted mucins (MUC2, MUC5AC, MUC5B, MUC6 and MUC7) in mucoepidermoid carcinomas of salivary glands
    Llucia Alos
    Department of Pathology, Hospital Clinic, IDIBAPS, University of Barcelona, Villaroel 170, 08036 Barcelona, Spain
    Am J Surg Pathol 29:806-13. 2005
    ..The aim of this study was to investigate the expression of mucins (MUC1, MUC2, MUC4, MUC5AC, MUCB, MUC6, MUC7) in mucoepidermoid carcinomas, the most frequent malignant tumor of salivary glands...
  60. pmc MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease
    Sara Kirkham
    1Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Am J Respir Crit Care Med 178:1033-9. 2008
    ..The polymeric mucins are major macromolecules in the secretion. Therefore, we hypothesized that the polymeric mucin composition or properties may be different in the sputum from individuals with COPD and smokers without airflow ..
  61. ncbi Effect of pH on the association behavior in aqueous solutions of pig gastric mucin
    Atoosa Maleki
    Department of Chemistry, University of Oslo, PO Box 1033, Blindern, N 0315 Oslo, Norway
    Carbohydr Res 343:328-40. 2008
    ..to examine the impact of pH (1 < or = pH < or = 7) on aqueous solutions of noncommercial purified pig gastric mucin. The asymmetric flow field-flow fractionation (AFFFF) measurements established that the mucin sample has a ..
  62. doi Significance of mucin expression in pancreatobiliary neoplasms
    Suguru Yonezawa
    Department of Human Pathology, Field of Oncology, Course of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    J Hepatobiliary Pancreat Sci 17:108-24. 2010
    ..High de novo expression of MUC5AC (gastric-type secreted mucin) was observed in many types of pancreatobiliary neoplasms, including all grades of ..
  63. ncbi Assignment of human tracheobronchial mucin gene(s) to 11p15 and a tracheobronchial mucin-related sequence to chromosome 13
    V C Nguyen
    Laboratorie de Cytogénétique et de Génétique Oncologiques URA 1158 CNRS, Institut Gustave Roussy, Villejuif, France
    Hum Genet 86:167-72. 1990
    Extensive heterogeneity of tracheobronchial mucin RNAs has been described recently. Based on the results of total or partial cDNA sequencing, the mucin cDNAs obtained were classified into three groups...
  64. pmc An inventory of mucin genes in the chicken genome shows that the mucin domain of Muc13 is encoded by multiple exons and that ovomucin is part of a locus of related gel-forming mucins
    Tiange Lang
    Department of Medical Biochemistry, Goteborg University, Goteborg, Sweden
    BMC Genomics 7:197. 2006
    ..We have developed computational methods to identify mucin genes and proteins based on these properties of the proteins...
  65. pmc Nitric oxide induces MUC5AC mucin in respiratory epithelial cells through PKC and ERK dependent pathways
    Jeong Sup Song
    Department of Internal Medicine, St Mary s Hospital, Catholic University Medical College, Yeoi Do Dong, Young Dung Po Gu, Seoul, Korea
    Respir Res 8:28. 2007
    ..In this study, we investigated potential signaling pathways involving protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) in the NO-induced MUC5AC mucin gene and protein expression in A549 cells.
  66. ncbi Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B
    P A Nielsen
    Department of Oral Diagnostics, Faculty of Health Sciences, School of Dentistry, University of Copenhagen, Denmark
    Glycobiology 7:413-9. 1997
    ..A single clone, SAL1, was identified and found to be encoded by tracheobronchial mucin gene MUC5B...
  67. ncbi Gene expression of gastric type mucin (MUC5AC) in pancreatic tumors: its relationship with the biological behavior of the tumor
    S Yonezawa
    Second Department of Pathology, Faculty of Medicine, Kagoshima University, Kagoshima City, Japan
    Pathol Int 49:45-54. 1999
    ..The gastric type secretory mucin, MUC5AC, is strongly expressed in the surface mucous cells of gastric mucosa...
  68. doi In vitro evidence of nerve growth factor effects on human conjunctival epithelial cell differentiation and mucin gene expression
    Alessandro Lambiase
    CIR Laboratory of Ophthalmology, University Campus Bio Medico, Rome, Italy
    Invest Ophthalmol Vis Sci 50:4622-30. 2009
    ..Alterations in goblet cell numbers and mucin secretion are observed in chronic ocular surface inflammatory diseases...
  69. pmc Role of GP82 in the selective binding to gastric mucin during oral infection with Trypanosoma cruzi
    Daniela I Staquicini
    Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, Sao Paulo, Brasil
    PLoS Negl Trop Dis 4:e613. 2010
    ..route of infection may involve selective binding of the metacyclic trypomastigote surface molecule gp82 to gastric mucin as a first step towards invasion of the gastric mucosal epithelium and subsequent systemic infection...
  70. doi Normal and shear forces between surfaces bearing porcine gastric mucin, a high-molecular-weight glycoprotein
    Neale M Harvey
    The Physical and Theoretical Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QZ, United Kingdom
    Biomacromolecules 12:1041-50. 2011
    ..to measure the normal and shear forces between two mica surfaces each bearing an adsorbed layer of porcine gastric mucin ("Orthana" mucin), genetically similar to human MUC6...
  71. pmc Physical characterization of the MUC5AC mucin: a highly oligomeric glycoprotein whether isolated from cell culture or in vivo from respiratory mucous secretions
    J K Sheehan
    The Wellcome Trust Centre for Cell Matrix Research, Division of Biochemistry, School of Biological Sciences, 2 205, Stopford Building, University of Manchester, Manchester M13 9PT, U K
    Biochem J 347:37-44. 2000
    ..34-1.44 g/ml) were reactive with an anti-peptide antiserum (MAN-5ACI) raised against a sequence from within the MUC5AC mucin. Similar antisera raised against the MUC2 and MUC5B mucins were not reactive...
  72. ncbi Regulation of mucous differentiation and mucin gene expression in the tracheobronchial epithelium
    T Gray
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicology 160:35-46. 2001
    ..normal human tracheobronchial epithelial (NHTBE) cells that were shown to secrete two major airway mucins, namely MUC5AC and MUC5B as well as several other secretory products...
  73. doi Immunohistochemical analysis of pyloric gland adenomas using a series of Mucin 2, Mucin 5AC, Mucin 6, CD10, Ki67 and p53
    Michael Vieth
    Institute of Pathology, Klinikum Bayreuth, Germany
    Virchows Arch 457:529-36. 2010
    ..with PGA with and without adenocarcinomas of the gastrointestinal tract, an immunhistochemical panel of Mucin 2, Mucin 5AC, Mucin 6, CD10, Ki67 and p53 was used to define the expression of these markers...
  74. ncbi Muc5b and Muc5ac are the major oligomeric mucins in equine airway mucus
    Karine Rousseau
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 292:L1396-404. 2007
    ..of tryptic digests of the unfractionated mucin preparation showed that the oligomeric mucins Muc5b and Muc5ac were present...
  75. pmc Molecular cloning and sequencing of a canine tracheobronchial mucin cDNA containing a cysteine-rich domain
    M Verma
    Department of Biochemistry and Molecular Biology, Georgetown University, Washington, DC 20007
    Proc Natl Acad Sci U S A 90:7144-8. 1993
    To date the complete sequence of only one mammalian mucin cDNA, MUC1, has been reported, although several mucin proteins have been partially characterized...
  76. ncbi Mucins and mucin binding proteins in colorectal cancer
    James C Byrd
    The Department of Gastrointestinal Medicine and Nutrition, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 436 Houston, TX 77030, USA
    Cancer Metastasis Rev 23:77-99. 2004
    ..There are two structurally and functionally distinct classes of mucins: secreted gel-forming mucins (MUC2, MUC5AC, MUC5B, and MUC6) and transmembrane mucins (MUC1, MUC3A, MUC3B, MUC4, MUC12, MUC17), although the products of some ..
  77. ncbi Characterization of mucins from cultured normal human tracheobronchial epithelial cells
    D J Thornton
    The Wellcome Trust Centre for Cell Matrix Research, Division of Biochemistry, School of Biological Sciences, University of Manchester, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 278:L1118-28. 2000
    ..a mucociliary epithelium over a 2- to 3-wk period and express increasing mRNA levels of the airway mucin genes MUC5AC and MUC5B as the cultures age; the levels of MUC2 mRNA were very low throughout the study...
  78. ncbi Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer
    Emad A Rakha
    Department of Histopathology, The Breast Unit, Nottingham City Hospital, University of Nottingham, Nottingham, UK
    Mod Pathol 18:1295-304. 2005
    ..technology and immunohistochemistry to evaluate the expression profiles of several mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and to assess their prognostic value. We detected MUC1 expression in 91% of tumours...
  79. pmc Assay of mucins in human tear fluid
    Sandra Spurr-Michaud
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Exp Eye Res 84:939-50. 2007
    Mucin genes, both secreted (MUC2, MUC5AC, MUC5B, MUC7) and membrane associated (MUC1, MUC4, MUC16), have been reported to be expressed by ocular surface epithelia...
  80. ncbi Allelic association and recombination hotspots in the mucin gene (MUC) complex on chromosome 11p15.5
    K Rousseau
    The Galton Laboratory, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK
    Ann Hum Genet 71:561-9. 2007
    ..5; tel MUC6-MUC2-MUC5AC-MUC5B cen; approx. 400 kb)...
  81. pmc Intestinal differentiation in metaplastic, nongoblet columnar epithelium in the esophagus
    Hejin P Hahn
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 33:1006-15. 2009
    ..markers of intestinal differentiation, such as MUC2, DAS-1, Villin, and CDX2, a marker of gastric differentiation (MUC5AC), and Ki67, a marker of cell proliferation...
  82. ncbi [Effect of peroxisome proliferators activated receptor gamma and its ligand on airway mucus hypersecretion in rats]
    Wei Jia Liu
    Department of Respiratory Medicine, Sichuan University West China Hospital, Chengdu 610041, China
    Zhonghua Jie He He Hu Xi Za Zhi 32:282-6. 2009
    ..To explore the effect and the molecular mechanisms of peroxisome proliferators activated receptor gamma (PPAR-gamma) and its ligand on airway mucus hypersecretion...
  83. ncbi Increased expression of human calcium-activated chloride channel 1 is correlated with mucus overproduction in the airways of Chinese patients with chronic obstructive pulmonary disease
    Ke Wang
    Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, and Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China
    Chin Med J (Engl) 120:1051-7. 2007
    ..To investigate the relationship of CaCC(1) and mucus overproduction in the airway of Chinese patients with COPD, the expressions of CaCC(1), MUC5AC and mucus in bronchial tissues were examined.
  84. ncbi Development and application of an in vitro methodology to determine the transit tolerance of potentially probiotic Lactobacillus and Bifidobacterium species in the upper human gastrointestinal tract
    W P Charteris
    SET Consultants Ltd, Douglas, Cork, Ireland
    J Appl Microbiol 84:759-68. 1998
    ..The methodology was also employed to determine the effect of adding milk proteins (1 g l-1), hog gastric mucin (1 g l-1) and soyabean trypsinchymotrypsin inhibitor [SBTCI] (1 g l-1) on transit tolerance...
  85. ncbi Decreased expression of human aquaporin-5 correlated with mucus overproduction in airways of chronic obstructive pulmonary disease
    Ke Wang
    Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, and Department of Respiratory Medicine, West China Hospital of Sichuan University, Sichuan, China
    Acta Pharmacol Sin 28:1166-74. 2007
    ..To investigate the relationship between aquaporin-5 (AQP5) expression and mucus overproduction in the airways of Chinese patients with chronic obstructive pulmonary disease (COPD) and the correlation with pulmonary function change...
  86. ncbi Gastric and intestinal differentiation in Barrett's metaplasia and associated adenocarcinoma
    P Chaves
    Grupo de Estudo do Esófago de Barrett, Instituto Portugues de Oncologia Francisco Gentil, Centro Regional de Oncologia de Lisboa SA, Portugal
    Dis Esophagus 18:383-7. 2005
    ..We studied 46 columnar-lined esophageal segments, 15 with associated adenocarcinoma. The presence of the gastric, MUC5AC and MUC6, and the intestinal, MUC2, proteins was evaluated in metaplastic (columnar and goblet) and neoplastic ..
  87. pmc Titanium dioxide particle-induced goblet cell hyperplasia: association with mast cells and IL-13
    Mi Hyun Ahn
    Genome Research Center for Allergy and Respiratory disease, Soonchunhyang University Hospital, Bucheon, Korea
    Respir Res 6:34. 2005
    ..However, the underlying mechanisms remain poorly understood...
  88. pmc Complement C3a regulates Muc5ac expression by airway Clara cells independently of Th2 responses
    Patricia Dillard
    The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, TX 77030, USA
    Am J Respir Crit Care Med 175:1250-8. 2007
    ..Although the complement anaphylatoxin C3a and its receptor have been shown to promote many features of allergic lung inflammation, the contribution to mucin expression has not been elucidated.
  89. pmc Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements
    Hays W J Young
    Department of Pulmonary Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Respir Cell Mol Biol 37:273-90. 2007
    ..Five orthologous genes (MUC2, MUC5AC, MUC5B, MUC6, and MUC19) encode the mammalian gel-forming mucin family, and several have been implicated in asthma,..
  90. ncbi Filtering blebs and aqueous pathway an immunocytological and in vivo confocal microscopy study
    Nawel Amar
    Department of Ophthalmology III, Quinze Vingts National Ophthalmology Hospital, Paris, France
    Ophthalmology 115:1154-1161.e4. 2008
    ..To characterize and understand, at the cellular level, the aqueous humor pathways after filtering surgery, using in vivo confocal microscopy and impression cytology (IC)...
  91. doi Alterations of matrix metalloproteinases, gastric mucin and prostaglandin E(2) levels by pectic polysaccharide of swallow root (Decalepis hamiltonii) during ulcer healing
    Belagihally M Srikanta
    Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Karnataka, India
    Biochimie 92:194-203. 2010
    ..In the current study, alteration of matrix metalloproteinases, gastric mucin and prostaglandin E(2) levels during polysaccharide mediated ulcer healing was determined in acetic acid ..
  92. ncbi pH-dependent intraluminal organization of mucin granules in live human mucous/goblet cells
    Juan Perez-Vilar
    Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7248, USA
    J Biol Chem 280:16868-81. 2005
    ..mucin packaging within mucin granules, we generated human mucous/goblet cells stably expressing a recombinant MUC5AC domain fused to green fluorescent protein (GFP)...
  93. pmc Interleukin-13-induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells
    Jinming Zhao
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 179:782-90. 2009
    15-Lipoxygenase-1 (15LO1) and MUC5AC are highly expressed in asthmatic epithelial cells. IL-13 is known to induce 15LO1 and MUC5AC in human airway epithelial cells in vitro...
  94. doi Differential protein immunoexpression profiles in appendiceal mucinous neoplasms: a special reference to classification and predictive factors
    Sun Och Yoon
    Department of Pathology, Seoul National University Boramae Hospital, Seoul, Korea
    Mod Pathol 22:1102-12. 2009
    ..E-cadherin, FHIT, hMLH1, p53, p63, smad4), cell-cycle regulators (p21, p27, p16), and mucin proteins (MUC1, MUC2, MUC5AC, MUC6)...
  95. pmc Entrapment of conjunctival goblet cells by desiccation-induced cornification
    Rosa Maria Corrales
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 52:3492-9. 2011
    ..To evaluate the effects of desiccating stress on conjunctival goblet cell density and morphology and the expression of cornified envelope precursors by the ocular surface epithelia...
  96. ncbi Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family
    J L Desseyn
    INSERM 377 Laboratoire Gérard Biserte, Place de Verdun, 59045 Lille Cedex, France
    J Biol Chem 272:3168-78. 1997
    Human mucin gene MUC5B is mapped clustered with MUC6, MUC2, and MUC5AC on chromosome 11p15.5. We report here the isolation of three overlapping genomic clones of human MUC5B spanning approximately 40 kilobases...
  97. ncbi Mucin gene expression (MUC1, MUC2, and MUC5/5AC) in nasal epithelial cells of cystic fibrosis, allergic rhinitis, and normal individuals
    J A Voynow
    Department of Pediatrics, George Washington University School of Medicine, Washington, D C 20010, USA
    Lung 176:345-54. 1998
    ..One possible explanation for this cascade of events is increased or altered expression of one or more mucin (MUC) genes by CF cells in the respiratory tract...
  98. pmc Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-beta/Smad4 signalling pathway is potentiated by Sp1
    Nicolas Jonckheere
    Unité INSERM U560, Place de Verdun, 59045 Lille Cedex, France
    Biochem J 377:797-808. 2004
    ..In our laboratory we have shown previously that MUC5AC is aberrantly expressed in rectosigmoid villous adenomas...
  99. ncbi Human pancreatic mucinous cystadenoma is characterized by distinct mucin, cytokeratin and CD10 expression compared with intraductal papillary-mucinous adenoma
    A Handra-Luca
    Service d Anatomie Pathologique, Hopital Beaujon, Clichy, France
    Histopathology 48:813-21. 2006
    To examine cytokeratin, epithelial glycoprotein (mucin) and glycoprotein CD10 expression in benign mucinous cystdenomas (MCAs) in comparison with intraductal papillary mucinous adenomas (IPMAs).
  100. ncbi Mucin core polypeptide expression in the progression of neoplasia in Barrett's esophagus
    Jonathan N Glickman
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Pathol 37:1304-15. 2006
    ..with high-grade dysplasia [HGD]) were immunostained (ABC method) with antibodies against MUC1, MUC2, MUC3, MUC5AC, and MUC6...
  101. doi Clinical impact of preoperative screening for gastric mucin secretion in cervical discharge by HIK1083-labeled latex agglutination test
    Makiko Omori
    Obstetrics and Gynecology, National University Corporation University of Yamanashi, Yamanashi, Japan
    Am J Clin Pathol 130:585-94. 2008
    The present study evaluated the clinical impact of preoperative screening for gastric mucin in cervical discharge, using a latex agglutination test with HIK1083, a monoclonal antibody against gastric mucin...

Research Grants52

  1. LAURA ELIZABETH MARTINEZ; Fiscal Year: 2015
    ..record the swimming behavior and determine the directional switching frequency of the bacteria in purified gastric mucin, the relevant polymer for H. pylori in the stomach (aim 1A)...
  2. IL8-induced Post-transcriptional Regulation of the MUC5AC mucin gene
    Mary C Rose; Fiscal Year: 2010
    ..b>MUC5AC, a major airway mucin, is localized to goblet cells in the conducting airway epithelium and overexpressed in lung ..
  3. Stephen C Pflugfelder; Fiscal Year: 2016
    ..represses conjunctival goblet cell maturation by increasing expression of FoxA2, a transcriptional repressor of MUC5AC mucin, as well as the IL-13 decoy receptor, IL-13 receptor alpha 2 that avidly binds IL-13 and inhibits IL-13 ..
  4. REGULATION OF GASTRIC MUCIN SYNTHESIS
    CLEMENT BOLAND; Fiscal Year: 1990
    ..In spite of this important protective role, details about the regulation of gastric mucin synthesis and secretion are limited, primarily because of the complexities of intact gastric mucosa...
  5. Regulation of MUC19 by Th2 cytokine in airway epithelium
    Yin Chen; Fiscal Year: 2011
    ..change of surface airway epithelial cells from the sole expression of the "surface" type of gel-forming mucin -MUC5AC to the co-expression with the submucosal gland-specific MUC5B and MUC19, a novel gel-forming we newly discovered, ..
  6. Modulation of conjunctival goblet cell differentiation by immunoregulatory cells
    Cintia Sade de Paiva; Fiscal Year: 2010
    ..will be confirmed by evaluating goblet cell and CD4+ cell density and expression of the goblet cell mucin MUC5AC and metaplasia marker small proline rich residue 2 protein (SPRR-2) in conjunctival sections from normal and dry ..
  7. Pi Wan Cheng; Fiscal Year: 2015
    ..and H292 cells with and without heat shock will be the test models because they express C2GnT-L, C2GnT-M, MUC1 and MUC5AC, which allows assessment of changes in mucin glycan structures in these two mucins following disruption of Golgi ..
  8. Specialized molecules with essential roles in mucus production
    David J Erle; Fiscal Year: 2013
    ..In a mouse model of asthma, production of the major airway mucin MUC5AC was reduced but not abolished in Agr2-/- mice...
  9. Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
    Reen Wu; Fiscal Year: 2013
    ..Preliminary studies have shown the presence of CpG islands in the upstream promoter region of human MUC5AC (at -4,396 bp - 4,541bp), which is not present in the mouse orthologue...
  10. Darlene A Dartt; Fiscal Year: 2015
    ..Corneal response to infection is constrained, but conjunctiva can respond exuberantly. In particular the MUC5AC-secreting conjunctival goblet cells are the first line of innate immune defense of the ocular surface with their ..
  11. Control of Mucin Glycan Branching in Membrane-bound and Secreted Mucins
    Pi Wan Cheng; Fiscal Year: 2010
    ..of core 2 structure in MUC1 and overexpression of C2GnT-L would not affect the levels of core 2 structure in MUC5AC, (2) targeting C2GnT-M and core 3 synthase to the sub-Golgi locations of C2GnT-L and core 1 synthase, respectively ..
  12. Jian dong Li; Fiscal Year: 2014
    ..During previous grant period, we found that Sp up-regulates MUC5AC mucin via activation of MAPK ERK;ERK activation also leads to induction of MKP-1, which in turn inhibits ERK and ..
  13. Christopher M Evans; Fiscal Year: 2016
    ..Autopsy studies show that 98% of the airways of patients who die from fatal asthma have extensive mucus plugging. MUC5AC and MUC5B are the major secreted airway mucins...
  14. Mehmet Kesimer; Fiscal Year: 2014
    ..Airway mucins, particularly MUC5AC and MUC5B, are the major constituent of the mucus gel and play an important role in the mucociliary clearance...
  15. Bacteria-Mucin Interactions at the Ocular Surface
    Ilene K Gipson; Fiscal Year: 2012
    ..the three types of bacteria bind to specific released mucins, MUCs 1, 4 and 16, and/or secreted goblet cell mucin MUC5AC present in the tear film, and whether such binding acts as a protective mechanism, preventing adhesion to HCLE ..
  16. Th2 effects on eicosanoid pathways: implications for altered innate responses in
    Sally E Wenzel; Fiscal Year: 2010
    ..of PG-related pathways and addressing the role of this inhibition of PG-related pathways on induction of mucin (MUC5AC), inducible nitric oxide (iNOS), 15 lipoxygenase (LO) 1, IL-8 and matrix metalloproteinase (MMP)-1...
  17. Mehmet Kesimer; Fiscal Year: 2014
    ..the organization of the airway gel layer, which is formed by very large glycoproteins termed mucins (MUC5B and MUC5AC) coupled with other protective biomolecules through labile interactions, and assess the role of these interactions ..
  18. Michael A Hollingsworth; Fiscal Year: 2015
    ..The earliest premalignant and malignant lesions in the pancreas express MUCI, MUC4, MUC5ac, MUC16, and MUC17 with truncated O-linked structures attached (Tn, sialyl Tn, T) but may not produce a sufficient ..
  19. Resolution of Epithelial Cell Hyperplasia
    Yohannes Tesfaigzi; Fiscal Year: 2013
    ..differentiated NHBECArg/Arg, NHBECArg/Pro, and NHBECPro/Pro cultures will show differences in secreted mucus, MUC5AC, Noxa, and Puma mRNA expression, and the development of MCM before and after exposure to ETS extract...
  20. Mary Ann Stepp; Fiscal Year: 2014
    ..progenitor cells, K8+K12+ cells which can proliferate, and K8+ post-mitotic differentiated goblet cells expressing Muc5ac. During homeostasis and after small debridement wounds, conventional and compound niche progenitor cells generate ..
  21. CYLD as a negative regulator for MUC5AC in NTHi-induced otitis media
    Erika Szymanski; Fiscal Year: 2007
    ..Mucus is largely the product of mucin glycoproteins including MUC5AC, which is strongly upregulated by bacterial infection...
  22. Mechanisms of Asbestos-Induced CIca1 and Mucin in Lung Epithelium
    Tara Sabo Attwood; Fiscal Year: 2009
    ..primary goal is to unveil signaling pathways altered by asbestos that regulate the expression of hclcal/mclcaS and muc5ac, two genes involved in mucin production and/or secretion...
  23. Attenuation of mucous cell metaplasia by Rad
    Mary Chang; Fiscal Year: 2006
    ..Both Northern blot and RealTime RT-PCR analysis demonstrated that the steady state level of MUC5B/MUC5AC mRNA were drastically inhibited by Rad...
  24. DAVID ALBERT SCHWARTZ; Fiscal Year: 2016
    ..Furthermore, we have found common variants in MUC5AC (chr11 positional candidate) that are associated with both FIP and IPF...
  25. IkB kinase-dependent regulation of mucin in otitis media
    Unhwan Ha; Fiscal Year: 2007
    ..These encouraging novel findings have thus led us to hypothesize that Gram- positive S. pneumoniae up-regulates MUC5AC mucin transcription via novel signaling networks involving IkappaB kinases-ERK signaling pathway in a NF-kappaB ..
  26. Regulation of the Muc5ac Gene in the Mouse Airway
    HAYS YOUNG; Fiscal Year: 2006
    ..However, during airway inflammation, mucin synthesis is increased dramatically...
  27. CREB in Differentiation of Bronchial Mucous Cells
    Ja Seok Koo; Fiscal Year: 2007
    ..Activation of CREB by RA is a prerequisite for basal MUC5AC expression and normal mucous differentiation, and chronic, persistent overexpression and activation of CREB by ..
  28. Detection and Role of C-Mannosylation in Mucins
    JUAN PEREZ VILAR; Fiscal Year: 2006
    ..Our preliminary data suggest the Cys subdomains in MUC5AC and MUC5B are C-mannosylated when expressed in cultured animal cells...
  29. Diesel Exhaust Particle Modulation of Inflammation
    Jeanclare Seagrave; Fiscal Year: 2005
    ....
  30. REGULATION OF MUCIN GENE EXPRESSION BY ELASTASE
    Judith Voynow; Fiscal Year: 2003
    ..be tested: 1) neutrophil elastase increases the stability of mRNAs coding for two major respiratory tracts mucins, MUC5AC and MUC4; 2) neutrophil elastase treatment of airway epithelial cells triggers generation of reactive oxygen ..
  31. Mucin Gene Regulation by Elastase and Oxidants
    Judith Voynow; Fiscal Year: 2008
    ..generates intracellular reactive oxygen species and these reactive oxygen species are required for NE-increased MUC5AC mucin expression...
  32. MUC4 Mucin and Airway Epithelial Regeneration in COPD
    Judith Voynow; Fiscal Year: 2006
    ..To date, the only ligand known to activate ErbB2 is MUC4. MUC4 is a major membrane-tethered, respiratory tract mucin with epidermal growth factor (EGF)-like domains...
  33. NEGATIVE REGULATORY ELEMENT OF HAMSTER MUC 1 PROMOTER
    Kwang Kim; Fiscal Year: 2003
    DESCRIPTION (Adapted from the Applicant's Abstract): MUC 1 is a transmembrane cell surface mucin best known for its upregulation in breast cancer...
  34. Effects of Tobacco Smoke on Airway Bactericidal Activity
    Yuan Pu Di; Fiscal Year: 2004
    ..Finally, the candidate may obtain a better understanding of the pathogenesis of bacterial infections in certain lung diseases under effects of tobacco smoke, and the development of new therapeutic strategies...
  35. A Sequencing Microarray for Mitochondrial Mutations
    Anirban Maitra; Fiscal Year: 2004
    ..This study will serve as a model for array-based diagnosis of cancer in clinical samples. ..
  36. GENETIC REGULATION OF 03-INDUCED INFLAMMATION
    W Foster; Fiscal Year: 2003
    ..abstract_text> ..
  37. GLYCOCONJUGATES IN PANCREATIC CANCER
    Young Kim; Fiscal Year: 2002
    ..Pancreatic tumors frequently exhibit alterations in mucin gene expression, providing both diagnostic and therapeutic opportunities...
  38. MUCIN SECRETION IN COLUMNAR EPITHELIAL CELLS
    Rahul Kuver; Fiscal Year: 2003
    ..A mechanistic understanding of mucin secretion has clinical relevance for a number of diseases including cystic fibrosis (CF), inflammatory bowel ..
  39. CHOLESTEROL TRANSPORT IN GALLBLADDER EPITHELIAL CELLS
    Rahul Kuver; Fiscal Year: 2003
    ..3. Compare and contrast the mechanisms of activation of ABCA1 via the cAMP responsive and the LXRalpha/RXR- responsive pathways. ..
  40. Thioredoxin in Neutrophil-Airway Epithelial Interactions
    Karen Oslund; Fiscal Year: 2008
    ..She hopes to use a career research award to gain additional knowledge and training in molecular biology while transitioning to an independent researcher who will be competitive for R01 funding. [unreadable] [unreadable] [unreadable]..
  41. MoAbs for the Management of Pancreatic Cancer
    David Gold; Fiscal Year: 2005
    ..Finally, a PAM4IL2 fusion protein will be examined for its ability to enhance tumor uptake of a subsequently administered radiolabeled PAM4 antibody. ..
  42. Middle Ear Epithelial Response to Cytokine Stimulation
    Joseph Kerschner; Fiscal Year: 2005
    ..interleukin-6 (IL- 6) and interleukin-8 (IL-8) will exhibit changes in: 1) mucoglycoprotein secretion (MGP), 2) mucin gene expression and 3) morphology...
  43. "Ligand Independent" endocrine disruption by pesticides
    Patrick Wong; Fiscal Year: 2005
    ..abstract_text> ..
  44. Genetic contributors to diabetes and dyslipidemia in African Americans
    Michele M Sale; Fiscal Year: 2010
    ..We propose applying this proven strategy to identify new therapeutic targets and allow translation to novel diagnostic, prevention, and treatment strategies for type 2 diabetes. ..
  45. Hedgehog signaling in pancreatic neoplasia
    Anirban Maitra; Fiscal Year: 2006
    ..Specifically, it will be determined whether Hh misexpression can generate a phenotype of multistep progression of pancreatic cancer that resembles the cognate human condition. [unreadable] [unreadable]..
  46. IL13-responsive genes in goblet cell metaplasia in asthma
    Mary Rose; Fiscal Year: 2007
    ..cell hyperplasia, GCH) in the airway epithelium is largely responsible for the deleterious overproduction of mucin glycoproteins in response to allergens and environmental toxins in patients with asthma...
  47. Dependency of O-3 Induced Lung Mucus Hypersecretion on NQ01
    W Michael Foster; Fiscal Year: 2010
    ..to O3 by susceptible humans activates NQO1, generates reactive oxygen metabolites and leads to an increase in MUC5AC mRNA expression and production of mucins by airway epithelial cells...
  48. Biliary oxysterols and cholangiocarcinoma
    RAHUL P KUVER; Fiscal Year: 2010
    ..on short term exposure to biliary epithelial cells, exhibit profound effects on apoptosis, cell proliferation, mucin synthesis and secretion...
  49. Anti-inflammatory role of MUC1 mucin
    Kwang Chul Kim; Fiscal Year: 2010
    ..Our laboratory made theinteresting observation that MUC1 mucin on the surface of airway epithelial cells is a specific binding site for PA mediated through bacterial flagellin...
  50. Mucin expression in rheumatoid arthritis
    MICHAEL VOLIN; Fiscal Year: 2008
    ..Preliminary data examining the expression of mucins in RA and osteoarthritis (OA) indicate that: 1) MUC3 and MUC5AC expression is upregulated in arthritic synovial tissue over normal synovial tissue; 2) synovial fibroblasts ..
  51. Cell Surface Modulation of EGFR-Mediated Differentiation
    Suil Kim; Fiscal Year: 2008
    ....